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Feline proliferative and necrotising otitis externa (PNOE) is a rare immune‐mediated condition, usually self‐limiting or responsive to immunosuppressants such as topical tacrolimus. This case report describes two cats with refractory PNOE that responded successfully to oclacitinib. One cat also had middle ear involvement and the other cat had extra‐auricular dermatitis. [ABSTRACT FROM AUTHOR]