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2. The Potential of Digital Twins in Healthcare: Evaluation of a Clinical Decision Support System for Chronic Inflammatory Bowel Disease

Author

Radic, Marija, Vosen, Agnes, Teichert, Anika, Bach, Friederike, Foldenauer, Ann Christina, Frank, Kevin, Köhm, Michaela, Blumenstein, Irina, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Daimi, Kevin, editor, and Al Sadoon, Abeer, editor

Published
2024
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3. Short-term predictor for COVID-19 severity from a longitudinal multi-omics study for practical application in intensive care units

Author

Kugler, Sabine, Hahnefeld, Lisa, Kloka, Jan Andreas, Ginzel, Sebastian, Nürenberg-Goloub, Elina, Zinn, Sebastian, Vehreschild, Maria JGT., Zacharowski, Kai, Lindau, Simone, Ullrich, Evelyn, Burmeister, Jan, Kohlhammer, Jörn, Schwäble, Joachim, Gurke, Robert, Dorochow, Erika, Bennett, Alexandre, Dauth, Stephanie, Campe, Julia, Knape, Tilo, Laux, Volker, Kannt, Aimo, Köhm, Michaela, Geisslinger, Gerd, Resch, Eduard, and Behrens, Frank

Published
2024
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4. Aligning Subjective Ratings in Clinical Decision Making

Author

Pick, Annika, Ginzel, Sebastian, Rüping, Stefan, Sander, Jil, Foldenauer, Ann Christina, and Köhm, Michaela

Subjects
Statistics - Applications, Computer Science - Machine Learning, Statistics - Machine Learning
Abstract

In addition to objective indicators (e.g. laboratory values), clinical data often contain subjective evaluations by experts (e.g. disease severity assessments). While objective indicators are more transparent and robust, the subjective evaluation contains a wealth of expert knowledge and intuition. In this work, we demonstrate the potential of pairwise ranking methods to align the subjective evaluation with objective indicators, creating a new score that combines their advantages and facilitates diagnosis. In a case study on patients at risk for developing Psoriatic Arthritis, we illustrate that the resulting score (1) increases classification accuracy when detecting disease presence/absence, (2) is sparse and (3) provides a nuanced assessment of severity for subsequent analysis., Comment: Accepted at the ECML 2020 workshop on Machine Learning for Pharma and Healthcare Applications (PharML)

Published
2020

5. Automated Hand Joint Classification of Psoriatic Arthritis Patients Using Routinely Acquired Near Infrared Fluorescence Optical Imaging

Author

Zerweck, Lukas, Wesarg, Stefan, Kohlhammer, Jörn, Köhm, Michaela, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Wesarg, Stefan, editor, Puyol Antón, Esther, editor, Baxter, John S. H., editor, Erdt, Marius, editor, Drechsler, Klaus, editor, Oyarzun Laura, Cristina, editor, Freiman, Moti, editor, Chen, Yufei, editor, Rekik, Islem, editor, Eagleson, Roy, editor, Feragen, Aasa, editor, King, Andrew P., editor, Cheplygina, Veronika, editor, Ganz-Benjaminsen, Melani, editor, Ferrante, Enzo, editor, Glocker, Ben, editor, Moyer, Daniel, editor, and Petersen, Eikel, editor

Published
2023
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6. Machine Learning Based Approach for Motion Detection and Estimation in Routinely Acquired Low Resolution Near Infrared Fluorescence Optical Imaging

Author

Zerweck, Lukas, Wesarg, Stefan, Kohlhammer, Jörn, Köhm, Michaela, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Chen, Yufei, editor, Linguraru, Marius George, editor, Shekhar, Raj, editor, Wesarg, Stefan, editor, Erdt, Marius, editor, Drechsler, Klaus, editor, and Oyarzun Laura, Cristina, editor

Published
2023
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7. An HPA-1a–positive platelet–depleting agent for prevention of fetal and neonatal alloimmune thrombocytopenia: a randomized, single-blind, placebo–controlled, single-center, phase 1/2 proof-of-concept study

Author

Geisen, Christof, Kjaer, Mette, Fleck, Erika, Skogen, Bjorn, Armstrong, Róisín, Behrens, Frank, Bhagwagar, Zubin, Braeuninger, Susanne, Mortberg, Anette, Olsen, Klaus Juel, Gastón Schäfer, Stephan Martin, Walter, Carmen, Seifried, Erhard, Wikman, Agneta, Kjeldsen-Kragh, Jens, and Koehm, Michaela

Published
2023
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8. Cohort Enrichment Strategies for Progressive Interstitial Lung Disease in Systemic Sclerosis From European Scleroderma Trials and Research

Author

Vacca, Alessandra, Giollo, Alessandro, Balbir-Gurman, Alexandra, Gheorghiu, Ana Maria, Marcoccia, Antonella, Herrick, Ariane, Radic, Mislav, Stamenkovic, Bojana, Anic, Branimir, Granel, Brigitte, Ribi, Camillo, Selmi, Carlo Francesco, Carlos de la Puente, Milano, de Souza Müller, Carolina, Denton, Christopher, Kayser, Cristiane, Tanaseanu, Cristina-Mihaela, Majewski, Dominik, Rimar, Doron, Krasowska, Dorota, Veale, Douglas, Walker, Ulrich, Kerzberg, Eduardo, Rezus, Elena, Zanatta, Elisabetta, Siegert, Elise, De Langhe, Ellen, Oksel, Fahrettin, Ingegnoli, Francesca, Cantatore, Francesco Paolo, Szücs, Gabriela, Cuomo, Giovanna, Seskute, Goda, Litinsky, VilniusIra, Castellví, Ivan, Morovic-Vergles, Jadranka, Sibilia, Jean, Henes, Jörg, Solanki, Kamal, Perdan-Pirkmajer, Katja, Herrmann, Kristine, Saketkoo, Lesley Ann, Stamp, Lisa, Mouthon, Luc, Salvador, Maria João, Pozzi, Maria Rosa, Üprus, Maria, Vanthuyne, Marie, Engelhart, Merete, Köhm, Michaela, Iudici, Michele, Inanc, Murat, Fathi, Nihal, Pamuk, Nuri, García de la Peña Lefebv, Paloma, Carreira, Patricia E., Bancel, Dominique Farge, Moroncini, Luca, Montecucco, C., Ancuta, Codrina, Sunderkötter, Cord, Müller-Ladner, Ulf, Rosato, Edoardo, Kucharz, Eugene J., Iannone, Florenzo, Del Galdo, Francesco, Poormoghim, Hadi, Kötter, Ina, Distler, Jörg, Cutolo, Maurizio, Tikly, Mohammed, Damjanov, Nemanja, Hunzelmann, Nicolas, Vlachoyiannopoulos, P., Hasler, Paul, Sarzi Puttini, Piercarlo, Wiland, Piotr, Becvar, Radim, Yavuz, Sule, Zdrojewski, Zbigniew, Pellerito, Raffaele, Foti, Rosario, Ionescu, Ruxandra Maria, Adler, Sabine, Kahl, Sarah, Moiseev, Sergey, Stebbings, Simon, Rednic, Simona, Negrini, Simone, Heitmann, Stefan, Ullman, Susanne, Agachi, Svetlana, Martin, Thierry, Schmeiser, Tim, Riccieri, Valeria, Smith, Vanessa, Bernardino, Vera, Ortiz-Santamaria, Vera, Hsu, Vivien M., Abdel Atty Mohamed, Walid Ahmed, Hoffmann-Vold, Anna-Maria, Brunborg, Cathrine, Airò, Paolo, Ananyeva, Lidia P., Czirják, László, Guiducci, Serena, Hachulla, Eric, Li, Mengtao, Mihai, Carina, Riemekasten, Gabriela, Sfikakis, Petros P., Valentini, Gabriele, Kowal-Bielecka, Otylia, Allanore, Yannick, and Distler, Oliver

Published
2023
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9. Methotrexate plus ustekinumab versus ustekinumab monotherapy in patients with active psoriatic arthritis (MUST): a randomised, multicentre, placebo-controlled, phase 3b, non-inferiority trial

Author

Alten, Rieke H.E., Benesova, Karolina, Bergner, Raoul, Braun, Jürgen, Demary, Winfried, Finzel, Stephanie, Kästner, Peter, Kleye, Arnd, Krüger, Klaus, Lorenz, Gabriele, Max, Regina, Poddubnyy, Denis, Rubbert-Roth, Andrea, Schwenke, Holger, Sieburg, Maren, Thaci, Diamant, Thiele, Astrid, Voll, Reinhard E., von Hinüber, Ulrich, Walter, Jochen, Wassenberg, Siegfried, Koehm, Michaela, Rossmanith, Tanja, Foldenauer, Ann C, Herrmann, Eva, Brandt-Jürgens, Jan, Burmester, Gerd R, Kellner, Herbert, Kiltz, Uta, Kofler, David M, Rech, Jürgen, Mojtahed-Poor, Sorwe, Jonetzko, Christin, Burkhardt, Harald, and Behrens, Frank

Published
2023
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10. How do patient-reported outcome measures affect treatment intensification and patient satisfaction in the management of psoriatic arthritis? A cross sectional study of 503 patients.

Author

Coyle, Conor, Watson, Lily, Whately-Smith, Caroline, Brooke, Mel, Kiltz, Uta, Lubrano, Ennio, Queiro, Ruben, Trigos, David, Brandt-Juergens, Jan, Choy, Ernest, D'Angelo, Salvatore, Sedie, Andrea Delle, Dernis, Emmanuelle, Wirth, Théo, Guis, Sandrine, Helliwell, Philip, Ho, Pauline, Hueber, Axel, Joven, Beatriz, and Koehm, Michaela

Abstract

Objectives The AsseSSing Impact in pSoriatic Treatment (ASSIST) study investigated prescribing in routine PsA care and whether the patient-reported outcome—PsA Impact of Disease questionnaire (PsAID-12)—impacted treatment. This study also assessed a range of patient and clinician factors and their relationship to PsAID-12 scoring and treatment modification. Methods Patients with PsA were selected across the UK and Europe between July 2021 and March 2022. Patients completed the PsAID questionnaire and the results were shared with their physician. Patient characteristics, disease activity, current treatment methods, treatment strategies, medication changes and patient satisfaction scores were recorded. Results A total of 503 patients were recruited. Some 36.2% had changes made to treatment, and 88.8% of these had treatment escalation. Overall, the mean PsAID-12 score was higher for patients with treatment escalation; increase in PSAID-12 score is associated with increased odds of treatment escalation (odds ratio 1.58; P  < 0.0001). However, most clinicians reported that PsAID-12 did not impact their decision to escalate treatment, instead supporting treatment reduction decisions. Physician's assessment of disease activity had the most statistically significant effect on likelihood of treatment escalation (odds ratio 2.68, per 1-point score increase). Escalation was more likely in patients not treated with biologic therapies. Additional factors associated with treatment escalation included: patient characteristics, physician characteristics, disease activity and disease impact. Conclusion This study highlights multiple factors impacting treatment decision-making for individuals with PsA. PsAID-12 scoring correlates with multiple measures of disease severity and odds of treatment escalation. However, most clinicians reported that the PsAID-12 did not influence treatment escalation decisions. Psoriatic Arthritis Impact of Disease (PsAID) scoring could be used to increase confidence in treatment de-escalation. [ABSTRACT FROM AUTHOR]

Published
2025
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11. An international multicentre analysis of current prescribing practices and shared decision-making in psoriatic arthritis.

Author

Watson, Lily, Coyle, Conor, Whately-Smith, Caroline, Brooke, Melanie, Kiltz, Uta, Lubrano, Ennio, Queiro, Rubén, Trigos, David, Brandt-Juergens, Jan, Choy, Ernest, D'Angelo, Salvatore, Sedie, Andrea Delle, Dernis, Emmanuelle, Guis, Sandrine, Helliwell, Philip, Ho, Pauline, Hueber, Axel J, Joven, Beatriz, Koehm, Michaela, and Montilla, Carlos

Subjects
CROSS-sectional method, PSORIATIC arthritis, RESEARCH funding, HUMAN beings, SCIENTIFIC observation, QUESTIONNAIRES, DECISION making, TREATMENT effectiveness, ANTIRHEUMATIC agents, DESCRIPTIVE statistics, PHYSICIAN practice patterns, RESEARCH, DRUG prescribing
Abstract

Objectives Shared decision-making (SDM) is advocated to improve patient outcomes in PsA. We analysed current prescribing practices and the extent of SDM in PsA across Europe. Methods The ASSIST study was a cross-sectional observational study of PsA patients ≥18 years of age attending face-to-face appointments between July 2021 and March 2022. Patient demographics, current treatment and treatment decisions were recorded. SDM was measured by the clinician's effort to collaborate (CollaboRATE questionnaire) and patient communication confidence (PEPPI-5 tool). Results A total of 503 patients were included from 24 centres across the UK, France, Germany, Italy and Spain. Physician- and patient-reported measures of disease activity were highest in the UK. Conventional synthetic DMARDs constituted a higher percentage of current PsA treatment in the UK than continental Europe (66.4% vs 44.9%), which differed from biologic DMARDs (36.4% vs 64.4%). Implementing treatment escalation was most common in the UK. CollaboRATE and PEPPI-5 scores were high across centres. Of 31 patients with low CollaboRATE scores (<4.5), no patients with low PsAID-12 scores (<5) had treatment escalation. However, of 465 patients with CollaboRATE scores ≥4.5, 59 patients with low PsAID-12 scores received treatment escalation. Conclusions Higher rates of treatment escalation seen in the UK may be explained by higher disease activity and a younger cohort. High levels of collaboration in face-to-face PsA consultations suggests effective implementation of the SDM approach. Our data indicate that in patients with mild disease activity, only those with higher perceived collaboration underwent treatment escalation. Prospective studies should examine the impact of SDM on PsA patient outcomes. Trial registration clinicaltrials.gov , NCT05171270. [ABSTRACT FROM AUTHOR]

Published
2024
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14. How do patient-reported outcome measures affect treatment intensification and patient satisfaction in the management of psoriatic arthritis? A cross sectional study of 503 patients

Author

Coyle, Conor, primary, Watson, Lily, additional, Whately-Smith, Caroline, additional, Brooke, Mel, additional, Kiltz, Uta, additional, Lubrano, Ennio, additional, Queiro, Ruben, additional, Trigos, David, additional, Brandt-Juergens, Jan, additional, Choy, Ernest, additional, D’Angelo, Salvatore, additional, Delle Sedie, Andrea, additional, Dernis, Emmanuelle, additional, Wirth, Théo, additional, Guis, Sandrine, additional, Helliwell, Philip, additional, Ho, Pauline, additional, Hueber, Axel, additional, Joven, Beatriz, additional, Koehm, Michaela, additional, Morales, Carlos Montilla, additional, Packham, Jon, additional, Pinto Tasende, Jose Antonio, additional, Ramírez, Julio, additional, Ruyssen-Witrand, Adeline, additional, Scrivo, Rossana, additional, Twigg, Sarah, additional, Welcker, Martin, additional, Soubrier, Martin, additional, Gossec, Laure, additional, and Coates, Laura C, additional

Published
2024
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15. An international multi-centre analysis of current prescribing practices and shared decision-making in psoriatic arthritis

Author

Watson, Lily, primary, Coyle, Conor, additional, Whately-Smith, Caroline, additional, Brooke, Melanie, additional, Kiltz, Uta, additional, Lubrano, Ennio, additional, Queiro, Rubén, additional, Trigos, David, additional, Brandt-Juergens, Jan, additional, Choy, Ernest, additional, D'Angelo, Salvatore, additional, Delle Sedie, Andrea, additional, Dernis, Emmanuelle, additional, Guis, Sandrine, additional, Helliwell, Philip, additional, Ho, Pauline, additional, Hueber, Axel J, additional, Joven, Beatriz, additional, Koehm, Michaela, additional, Montilla, Carlos, additional, Packham, Jon, additional, Pinto Tasende, José Antonio, additional, Ramirez Garcia, Felipe Julio, additional, Ruyssen-Witrand, Adeline, additional, Scrivo, Rossana, additional, Twigg, Sarah, additional, Soubrier, Martin, additional, Wirth, Théo, additional, Gossec, Laure, additional, and Coates, Laura C, additional

Published
2023
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17. Impact of different classes of immune-modulating treatments on B cell-related and T cell-related immune response before and after COVID-19 booster vaccination in patients with immune-mediated diseases and primary immunodeficiency: a cohort study

Author

Koehm, Michaela, primary, Klippstein, Maximilian, additional, Dauth, Stephanie, additional, Hallmann, Konstantin, additional, Kohmer, Niko, additional, Burkhardt, Harald, additional, Ciesek, Sandra, additional, Geisslinger, Gerd, additional, Rabenau, Holger F, additional, and Behrens, Frank, additional

Published
2023
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19. Psoriatic Arthritis

Author

Koehm, Michaela, Behrens, Frank, Adebajo, Adewale, editor, Boehncke, Wolf-Henning, editor, Gladman, Dafna D., editor, and Mease, Philip J., editor

Published
2016
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20. ‘Status Quo’ on Different Aspects of Gender Distribution in Rheumatology in Germany—Results from a Nationwide Online Survey among Physicians

Author

Ohrndorf, Sarah, primary, Krusche, Martin, additional, Baraliakos, Xenofon, additional, Feist, Eugen, additional, Gundelach, Barbara, additional, Haase, Isabell, additional, Hoyer, Bimba Franziska, additional, Kiltz, Uta, additional, Koehm, Michaela, additional, Voormann, Anna Julia, additional, Sewerin, Philipp, additional, and Mucke, Johanna, additional

Published
2023
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25. P178 Current prescribing practices in psoriatic arthritis - comparison between the UK and Europe

Author

Watson, Lily, primary, Coyle, Conor, additional, Brooke, Melanie, additional, Kiltz, Uta, additional, Lubrano, Ennio, additional, Queiro, Rubén, additional, Trigos, David, additional, Brandt-Juergens, Jan, additional, D'Angelo, Salvatore, additional, Sedie, Andrea Delle, additional, Dernis, Emmanuelle, additional, Helliwell, Philip, additional, Ho, Pauline, additional, Hueber, Axel, additional, Joven, Beatriz, additional, Koehm, Michaela, additional, Montilla, Carlos, additional, Packham, Jon, additional, Tasende, José P, additional, Garcia, Felipe J R, additional, Ruyssen-Witrand, Adeline, additional, Scrivo, Rossana, additional, Twigg, Sarah, additional, Welcker, Martin, additional, Soubrier, Martin, additional, Wirth, Theo, additional, Gossec, Laure, additional, and Coates, Laura C, additional

Published
2023
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26. P179 Shared decision-making in psoriatic arthritis consultations

Author

Watson, Lily L, primary, Coyle, Conor, additional, Brooke, Melanie, additional, Kiltz, Uta, additional, Lubrano, Ennio, additional, Queiro, Rubén, additional, Trigos, David, additional, Brandt-Juergens, Jan, additional, D'Angelo, Salvatore, additional, Sedie, Andrea Delle, additional, Dernis, Emmanuelle, additional, Helliwell, Philip, additional, Ho, Pauline, additional, Hueber, Axel, additional, Joven, Beatriz, additional, Koehm, Michaela, additional, Montilla, Carlos, additional, Packham, Jon, additional, Tasende, José P, additional, Garcia, Felipe J R, additional, Ruyssen-Witrand, Adeline, additional, Scrivo, Rossana, additional, Twigg, Sarah, additional, Welcker, Martin, additional, Soubrier, Martin, additional, Wirth, Theo, additional, Gossec, Laure, additional, and Coates, Laura C, additional

Published
2023
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28. Methotrexate plus ustekinumab versus ustekinumab monotherapy in patients with active psoriatic arthritis (MUST): a randomised, multicentre, placebo-controlled, phase 3b, non-inferiority trial

Author

Koehm, Michaela, primary, Rossmanith, Tanja, additional, Foldenauer, Ann C, additional, Herrmann, Eva, additional, Brandt-Jürgens, Jan, additional, Burmester, Gerd R, additional, Kellner, Herbert, additional, Kiltz, Uta, additional, Kofler, David M, additional, Rech, Jürgen, additional, Mojtahed-Poor, Sorwe, additional, Jonetzko, Christin, additional, Burkhardt, Harald, additional, Behrens, Frank, additional, Alten, Rieke H.E., additional, Benesova, Karolina, additional, Bergner, Raoul, additional, Braun, Jürgen, additional, Demary, Winfried, additional, Finzel, Stephanie, additional, Kästner, Peter, additional, Kleye, Arnd, additional, Krüger, Klaus, additional, Lorenz, Gabriele, additional, Max, Regina, additional, Poddubnyy, Denis, additional, Rubbert-Roth, Andrea, additional, Schwenke, Holger, additional, Sieburg, Maren, additional, Thaci, Diamant, additional, Thiele, Astrid, additional, Voll, Reinhard E., additional, von Hinüber, Ulrich, additional, Walter, Jochen, additional, and Wassenberg, Siegfried, additional

Published
2023
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29. Application of clinical and molecular profiling data to improve patient outcomes in psoriatic arthritis

Author

FitzGerald, Oliver, primary, Behrens, Frank, additional, Barton, Anne, additional, Bertheussen, Heidi, additional, Boutouyrie-Dumont, Bruno, additional, Coates, Laura, additional, Davies, Owen, additional, de Wit, Maarten, additional, Fagni, Filippo, additional, Goodyear, Carl S., additional, Gurke, Robert, additional, Hahnefeld, Lisa, additional, Huppertz, Christine, additional, Ioannidis, Vassilios, additional, Ibberson, Mark, additional, Katz, Arnon, additional, Klippstein, Maximilian, additional, Koehm, Michaela, additional, Korish, Shimon, additional, Mackay, Sina, additional, Martin, David A., additional, O’Sullivan, Denis, additional, Patel, Khadijah, additional, Rueping, Stefan, additional, Schett, Georg, additional, Scholich, Klaus, additional, Schwenk, Jochen M., additional, Siebert, Stefan, additional, Simon, David, additional, Vivekanantham, Arani, additional, and Pennington, Stephen R., additional

Published
2023
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30. Effectiveness of Different Rituximab Doses Combined with Leflunomide in the Treatment or Retreatment of Rheumatoid Arthritis: Part 2 of a Randomized, Placebo-Controlled, Investigator-Initiated Clinical Trial (AMARA)

Author

Koehm, Michaela, primary, Foldenauer, Ann C., additional, Rossmanith, Tanja, additional, Alten, Rieke, additional, Aringer, Martin, additional, Backhaus, Marina, additional, Burmester, Gerd R., additional, Feist, Eugen, additional, Kellner, Herbert, additional, Krueger, Klaus, additional, Müller-Ladner, Ulf, additional, Rubbert-Roth, Andrea, additional, Tony, Hans-Peter, additional, Wassenberg, Siegfried, additional, Burkhardt, Harald, additional, and Behrens, Frank, additional

Published
2022
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31. Fluorescence-optical imaging as a promising easy-to-use imaging biomarker to increase early psoriatic arthritis detection in patients with psoriasis: a cross-sectional cohort study with follow-up

Author

Koehm, Michaela, primary, Ohrndorf, Sarah, additional, Foldenauer, Ann C, additional, Rossmanith, Tanja, additional, Backhaus, Marina, additional, Werner, Stephanie G, additional, Burmester, Gerd R, additional, Wassenberg, Siegfried, additional, Koehler, Benjamin, additional, Burkhardt, Harald, additional, and Behrens, Frank, additional

Published
2022
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32. An HPA-1a–positive platelet–depleting agent for prevention of fetal and neonatal alloimmune thrombocytopenia: a randomized, single-blind, placebo-controlled, single-center, phase 1/2 proof-of-concept study

Author

Geisen, Christof, primary, Kjaer, Mette, additional, Fleck, Erika, additional, Skogen, Bjorn, additional, Armstrong, Róisín, additional, Behrens, Frank, additional, Bhagwagar, Zubin, additional, Braeuninger, Susanne, additional, Mortberg, Anette, additional, Olsen, Klaus Juel, additional, Schäfer, Stephan Martin Gastón, additional, Walter, Carmen, additional, Seifried, Erhard, additional, Wikman, Agneta, additional, Kjeldsen-Kragh, Jens, additional, and Koehm, Michaela, additional

Published
2022
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33. Management of Enthesitis in Patients With Psoriatic Arthritis: An Updated Literature Review Informing the 2021 GRAPPA Treatment Recommendations

Author

Eder, Lihi, primary, Mathew, Ashish J., additional, Carron, Philippe, additional, Bertheussen, Heidi, additional, Cañete, Juan D., additional, Azem, May, additional, Sedie, Andrea Delle, additional, Salvarani, Carlo, additional, Ranza, Roberto, additional, Elliott, Ashley, additional, Turkiewicz, Anthony, additional, de Toledo, Ricardo Acayaba, additional, Bukulmez, Hulya, additional, Stoenoiu, Maria S., additional, Mandelin, Arthur M., additional, Koehm, Michaela, additional, Lindsay, Chris A., additional, Siegel, Evan, additional, and Mease, Philip J., additional

Published
2022
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34. Omics and Multi-Omics Analysis for the Early Identification and Improved Outcome of Patients with Psoriatic Arthritis

Author

Gurke, Robert, Bendes, Annika, Bowes, John, Koehm, Michaela, Twyman, Richard M., Barton, Anne, Elewaut, Dirk, Goodyear, Carl, Hahnefeld, Lisa, Hillenbrand, Rainer, Hunter, Ewan, Ibberson, Mark, Ioannidis, Vassilios, Kugler, Sabine, Lories, Rik J., Resch, Eduard, Rueping, Stefan, Scholich, Klaus, Schwenk, Jochen M., Waddington, James C., Whitfield, Phil, Geisslinger, Gerd, FitzGerald, Oliver, Behrens, Frank, Pennington, Stephen R., Consortium, HIPPOCRATES, and Publica

Subjects
RISK, psoriatic arthritis, Biochemistry & Molecular Biology, Science & Technology, Medicine (miscellaneous), Biology and Life Sciences, psoriasis, Research & Experimental Medicine, multi-omics, METABOLOMICS, DIAGNOSIS, General Biochemistry, Genetics and Molecular Biology, IDENTIFY POTENTIAL BIOMARKERS, RHEUMATOID-ARTHRITIS, SERUM, ALPHA, Medicine, Research & Experimental, INFLAMMATION, PRECISION MEDICINE, Medicine and Health Sciences, PROTEOMICS, Pharmacology & Pharmacy, Life Sciences & Biomedicine, data integration, psoriatic diseases
Abstract

The definitive diagnosis and early treatment of many immune-mediated inflammatory diseases (IMIDs) is hindered by variable and overlapping clinical manifestations. Psoriatic arthritis (PsA), which develops in ~30% of people with psoriasis, is a key example. This mixed-pattern IMID is apparent in entheseal and synovial musculoskeletal structures, but a definitive diagnosis often can only be made by clinical experts or when an extensive progressive disease state is apparent. As with other IMIDs, the detection of multimodal molecular biomarkers offers some hope for the early diagnosis of PsA and the initiation of effective management and treatment strategies. However, specific biomarkers are not yet available for PsA. The assessment of new markers by genomic and epigenomic profiling, or the analysis of blood and synovial fluid/tissue samples using proteomics, metabolomics and lipidomics, provides hope that complex molecular biomarker profiles could be developed to diagnose PsA. Importantly, the integration of these markers with high-throughput histology, imaging and standardized clinical assessment data provides an important opportunity to develop molecular profiles that could improve the diagnosis of PsA, predict its occurrence in cohorts of individuals with psoriasis, differentiate PsA from other IMIDs, and improve therapeutic responses. In this review, we consider the technologies that are currently deployed in the EU IMI2 project HIPPOCRATES to define biomarker profiles specific for PsA and discuss the advantages of combining multi-omics data to improve the outcome of PsA patients. ispartof: BIOMEDICINES vol:10 issue:10 ispartof: location:Switzerland status: published

Published
2022

35. Management of Enthesitis in Patients With Psoriatic Arthritis: An Updated Literature Review Informing the 2021 GRAPPA Treatment Recommendations.

Author

Eder, Lihi, Mathew, Ashish J., Carron, Philippe, Bertheussen, Heidi, Cañete, Juan D., Azem, May, Sedie, Andrea Delle, Salvarani, Carlo, Ranza, Roberto, Elliott, Ashley, Turkiewicz, Anthony, de Toledo, Ricardo Acayaba, Bukulmez, Hulya, Stoenoiu, Maria S., Mandelin II, Arthur M., Koehm, Michaela, Lindsay, Chris A., Siegel, Evan, and Mease, Philip J.

Published
2023
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36. Genetic Analysis of MPO Variants in Four Psoriasis Subtypes in Patients from Germany

Author

Haskamp, Stefan, Horowitz, Joseph Simon, Oji, Vinzenz, Philipp, Sandra, Sticherling, Michael, Schäkel, Knut, Schuhmann, Sarah, Prinz, Jörg C., Burkhardt, Harald, Behrens, Frank, Böhm, Beate, Köhm, Michaela, Rech, Jürgen, Simon, David, Schett, Georg, Morrison, Kirsten, Gerdes, Sascha, Assmann, Gunter, Nimeh, Ali, Schuster, Volker, Jacobi, Arnd, Weyergraf, Ansgar, Reis, André, Uebe, Steffen, Wilsmann-Theis, Dagmar, Mößner, Rotraut, and Hüffmeier, Ulrike

Published
2021
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37. Disease progression in systemic sclerosis-overlap syndrome is significantly different from limited and diffuse cutaneous systemic sclerosis

Author

Moinzadeh, Pia, Aberer, Elisabeth, Ahmadi-Simab, Keihan, Blank, Norbert, Distler, Joerg H W, Fierlbeck, Gerhard, Genth, Ekkehard, Guenther, Claudia, Hein, Ruediger, Henes, Joerg, Herich, Lena, Herrgott, Ilka, Koetter, Ina, Kreuter, Alexander, Krieg, Thomas, Kuhr, Kathrin, Lorenz, Hanns-Martin, Meier, Florian, Melchers, Inga, Mensing, Hartwig, Mueller-Ladner, Ulf, Pfeiffer, Christiane, Riemekasten, Gabriela, Sárdy, Miklós, Schmalzing, Marc, Sunderkoetter, Cord, Susok, Laura, Tarner, Ingo H, Vaith, Peter, Worm, Margitta, Wozel, Gottfried, Zeidler, Gabriele, Hunzelmann, Nicolas, Ahrazoglu, Nil Mona, Becker, Mike Oliver, Mierau, Rudolf, Neeck, Gunther, Fiehn, Christoph, Juche, Aaron, Rubbert, Andrea, Weber, Manfred, Fischer-Betz, Rebecca, Sticherling, Michael, Burkhardt, Harald, Koehm, Michaela, Seitz, Cornelia S, Herink, Claudia, Foeldvári, Ivan, Norgauer, Johannes, Schoeffel, Dieter, Renner, Regina, Ziemer, Mirjana, Steinbrink, Kerstin, Stadler, Rudolf, Müller, Verena, Ziai, Mahzad, Karrer, Sigrid, Landthaler, Michael, Meyringer, Rotraud, Buslau, Michael, Tomsitz, Dirk, Lee, Hae- Hyuk, Lehmann, Percy, Gaebelein-Wissing, Noemi, Wagner, Marieke, Ebel, Joachim, Beyer, Christian, Varga, Rita, Bretterklieber, Agnes, Reichenberger, Frank, and Himsel, Andrea

Published
2015
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38. Rare Loss-of-Function Mutation in SERPINA3 in Generalized Pustular Psoriasis

Author

Frey, Silke, Sticht, Heinrich, Wilsmann-Theis, Dagmar, Gerschütz, Anne, Wolf, Katharina, Löhr, Sabine, Haskamp, Stefan, Frey, Benjamin, Hahn, Madelaine, Ekici, Arif B., Uebe, Steffen, Thiel, Christian, Reis, André, Burkhardt, Harald, Behrens, Frank, Köhm, Michaela, Rech, Jürgen, Schett, Georg, Assmann, Gunter, Kingo, Külli, Kõks, Sulev, Mössner, Rotraut, Prinz, Jörg C., Oji, Vinzenz, Schulz, Peter, Muñoz, Luis E., Kremer, Andreas E., Wenzel, Jörg, and Hüffmeier, Ulrike

Published
2020
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39. Rituximab plus leflunomide in rheumatoid arthritis: a randomized, placebo-controlled, investigator-initiated clinical trial (AMARA study)

Author

Behrens, Frank, primary, Koehm, Michaela, additional, Rossmanith, Tanja, additional, Alten, Rieke, additional, Aringer, Martin, additional, Backhaus, Marina, additional, Burmester, Gerd R, additional, Feist, Eugen, additional, Herrmann, Eva, additional, Kellner, Herbert, additional, Krueger, Klaus, additional, Lehn, Annette, additional, Müller-Ladner, Ulf, additional, Rubbert-Roth, Andrea, additional, Tony, Hans-Peter, additional, Wassenberg, Siegfried, additional, and Burkhardt, Harald, additional

Published
2021
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41. Incidences and risk factors of organ manifestations in the early course of systemic sclerosis: A longitudinal EUSTAR study

Author

Jaeger, Veronika K., Wirz, Elina G., Allanore, Yannick, Rossbach, Philipp, Riemekasten, Gabriela, Hachulla, Eric, Distler, Oliver, Airò, Paolo, Carreira, Patricia E., Gurman, Alexandra Balbir, Tikly, Mohammed, Vettori, Serena, Damjanov, Nemanja, Müller Ladner, Ulf, Distler, Jörg H. W., Mangtao, Li, Walker, Ulrich A., Ananieva, Lidia, Heitmann, Stefan, Rednic, Simona, Riccieri, Valeria, Szmyrka Kaczmarek, Magdalena, Farge, Dominique, Lapadula, Giovanni, Matucci Cerinic, Marco, Guiducci, Serena, Hunzelmann, Nicolas, Ricci, Massimo, Mihai, Carina, Veale, Douglas, Hesselstrand, Roger, Mariok, Eduardo, Smith, Vanessa, Tarner, Ingo H., Kucharz, Eugene J., Czirják, László, Martinovic, Duska, Solanki, Kamal, Ancuta, Codrina Mihaela, Sibilia, Jean, Paola, Caramaschi, Hassanien, Manal, Kahl, Sarah, Wigley, Frederick, Vanthuyne, Marie, Opris, Daniela, Radominski, Sebastião C., Monaco, Andrea Lo, Corrado, Ada, Koehm, Michaela, Codullo, Veronica, Radim, Bevcar, Loyo, Esthela, Üprus, Maria, Pellerito, Raffaele, Zenone, Thierry, Gabrielli, Armando, Kowal Bielecka, Otylia, Rozman, Blaz, Scorza, Raffaella, Saketkoo, Lesley Ann, Midtvedt, Oyvind, Von Mühlen, Carlos Alberto, Henes, Jörg, Branimir, Ani, Hasler, Paul, Yavuz, Sule, Adler, Sabine, Krummel Lorenz, Brigitte, Posa, Magdalena, Engelhart, Merete, Denton, Christopher, Krasowska, Dorota, Lefebvre, Paloma Garcia De La Peña, Cozzi, Franco, Mouthon, Luc, Rosato, Edoardo, Selmi, Carlo, Sancho, Juan José Alegre, Mallia, Carmel, Limonta, Massimiliano, Seidel, Matthias, Foti, Rosario, Stamp, Lisa, Ullman, Susanne, Stebbings, Simon, Santamaria, Vera Ortiz, Del Galdo, Francesco, De Langhe, Ellen, Mathieu, Alessandro, Sunderkötter, Cord, Eyerich, Kilian, Stamenkovic, Bojana, Novak, Srdan, Sampaio Barros, Percival D., Kayser, Cristiane, Litinsky, Ira, Couto, Maura, Jaeger, Veronika K., Wirz, Elina G., Allanore, Yannick, Rossbach, Philipp, Riemekasten, Gabriela, Hachulla, Eric, Distler, Oliver, Airã², Paolo, Carreira, Patricia E., Gurman, Alexandra Balbir, Tikly, Mohammed, Vettori, Serena, Damjanov, Nemanja, Mã¼ller ladner, Ulf, Distler, Jã¶rg H. W., Li, Mangtao, Walker, Ulrich A., Ananieva, Lidia, Heitmann, Stefan, Rednic, Simona, Riccieri, Valeria, Szmyrka kaczmarek, Magdalena, Farge, Dominique, Lapadula, Giovanni, Matucci cerinic, Marco, Guiducci, Serena, Hunzelmann, Nicola, Ricci, Massimo, Mihai, Carina, Veale, Dougla, Hesselstrand, Roger, Mariok, Eduardo, Smith, Vanessa, Tarner, Ingo H., Kucharz, Eugene J., Czirjã¡k, Lã¡szlã³, Martinovic, Duska, Solanki, Kamal, Ancuta, Codrina Mihaela, Sibilia, Jean, Paola, Caramaschi, Hassanien, Manal, Kahl, Sarah, Wigley, Frederick, Vanthuyne, Marie, Opris, Daniela, Radominski, Sebastiã£o C., Monaco, Andrea Lo, Corrado, Ada, Koehm, Michaela, Codullo, Veronica, Radim, Bevcar, Loyo, Esthela, Ãœprus, Maria, Pellerito, Raffaele, Zenone, Thierry, Gabrielli, Armando, Kowal bielecka, Otylia, Rozman, Blaz, Scorza, Raffaella, Saketkoo, Lesley Ann, Midtvedt, Oyvind, Von Mã¼hlen, Carlos Alberto, Henes, Jã¶rg, Branimir, Ani, Hasler, Paul, Yavuz, Sule, Adler, Sabine, Krummel lorenz, Brigitte, Posa, Magdalena, Engelhart, Merete, Denton, Christopher, Krasowska, Dorota, Lefebvre, Paloma Garcia De La Peã±a, Cozzi, Franco, Mouthon, Luc, Rosato, Edoardo, Selmi, Carlo, Sancho, Juan Josã© Alegre, Mallia, Carmel, Limonta, Massimiliano, Seidel, Matthia, Foti, Rosario, Stamp, Lisa, Ullman, Susanne, Stebbings, Simon, Santamaria, Vera Ortiz, Del Galdo, Francesco, De Langhe, Ellen, Mathieu, Alessandro, Sunderkã¶tter, Cord, Eyerich, Kilian, Stamenkovic, Bojana, Novak, Srdan, Sampaio barros, Percival D., Kayser, Cristiane, Litinsky, Ira, Couto, Maura, and University of Zurich

Subjects
Male, Genetics and Molecular Biology (all), Pulmonology, Blood Pressure, Vascular Medicine, Biochemistry, Scleroderma, Diagnostic Radiology, 0302 clinical medicine, Retrospective Studie, Longitudinal Studies, lcsh:Science, integumentary system, Incidence, Arteries, Systolic Pressure, 3. Good health, Echocardiography, Cohort, Regression Analysis, Human, medicine.medical_specialty, Imaging Techniques, Gastrointestinal Disease, Immunology, 1100 General Agricultural and Biological Sciences, Skin Diseases, 03 medical and health sciences, FEV1/FVC ratio, Rheumatology, 1300 General Biochemistry, Genetics and Molecular Biology, Humans, Autoantibodies, Retrospective Studies, Aged, 1000 Multidisciplinary, Biochemistry, Genetics and Molecular Biology (all), Proportional hazards model, lcsh:R, Biology and Life Sciences, Proteins, medicine.disease, Agricultural and Biological Sciences (all), Blood Vessels, lcsh:Q, Clinical Medicine, Ejection Fraction, Lung Diseases, Kidney Disease, Physiology, Gastrointestinal Diseases, lcsh:Medicine, Longitudinal Studie, Kaplan-Meier Estimate, Medicine (all), Lung Disease, Pericardial effusion, Risk Factors, Medizinische Fakultät, Immune Physiology, Ultrasound Imaging, Medicine and Health Sciences, 030212 general & internal medicine, Pulmonary Arteries, Connective Tissue Diseases, Immune System Proteins, Pulmonary Hypertension, Multidisciplinary, Ejection fraction, Radiology and Imaging, Incidence (epidemiology), 10051 Rheumatology Clinic and Institute of Physical Medicine, Middle Aged, Autoantibodie, Heart Disease, Kidney Diseases, Female, Anatomy, Research Article, Adult, Heart Diseases, Cardiology, 610 Medicine & health, Research and Analysis Methods, Antibodies, Regression Analysi, Autoimmune Diseases, Diagnostic Medicine, Internal medicine, medicine, ddc:610, 030203 arthritis & rheumatology, Scleroderma, Systemic, business.industry, Risk Factor, Skin Disease, Raynaud Disease, Retrospective cohort study, Surgery, Cardiovascular Anatomy, Clinical Immunology, business
Abstract

Objective Systemic sclerosis (SSc) is a rare and clinically heterogeneous autoimmune disorder characterised by fibrosis and microvascular obliteration of the skin and internal organs. Organ involvement mostly manifests after a variable period of the onset of Raynaud's phenomenon (RP). We aimed to map the incidence and predictors of pulmonary, cardiac, gastrointestinal (GI) and renal involvement in the early course of SSc. Methods In the EUSTAR cohort, patients with early SSc were identified as those who had a visit within the first year after RP onset. Incident SSc organ manifestations and their risk factors were assessed using Kaplan-Meier methods and Cox regression analysis. Results Of the 695 SSc patients who had a baseline visit within 1 year after RP onset, the incident non-RP manifestations (in order of frequency) were: skin sclerosis (75%) GI symptoms (71%), impaired diffusing capacity for monoxide40mmHg (14%), and renal crisis (3%). In the heart, incidence rates were highest for diastolic dysfunction, followed by conduction blocks and pericardial effusion. While the main baseline risk factor for a short timespan to develop FVC impairment was diffuse skin involvement, for PAPsys>40mmHg it was higher patient age. The main risk factors for incident cardiac manifestations were anti-topoisomerase autoantibody positivity and older age. Male sex, anti-RNA-polymerase-III positivity, and older age were risk factors associated with incident renal crisis. Conclusion In SSc patients presenting early after RP onset, approximately half of all incident organ manifestations occur within 2 years and have a simultaneous rather than a sequential onset. These findings have implications for the design of new diagnostic and therapeutic strategies aimed to ‘widen' the still very narrow ‘window of opportunity'. They may also enable physicians to counsel and manage patients presenting early in the course of SSc more accurately.

Published
2016

43. Rheumatoid arthritis - treatment: 180. Utility of Body Weight Classified Low-Dose Leflunomide in Japanese Rheumatoid Arthritis

Author

Nishikawa, Masataka, Owaki, Hajime, Fuji, Takeshi, Soliman, Moetaza M., Ashcroft, Darren M., Watson, Kath D., Lunt, Mark, Symmons, Deborah, Hyrich, Kimme L., Atkinson, Francesca, Malik, Saadia, Heycock, Carol, Saravanan, Vadivelu, Rynne, Martin, Hamilton, Jennifer, Kelly, Clive, Burmester, Gerd, Kary, Sonja, Unnebrink, Kristina, Guérette, Benoit, Oezer, Uemit, Kupper, Hartmut, Dennison, Elaine, Jameson, Karen, Hyrich, Kimme, Watson, Kath, Landewe, Robert, Keystone, Edward, Smolen, Josef, Goldring, Mary, Patra, Kaushik, Cifaldi, Mary, van der Heijde, Désirée, Lloyd, Lois A., Owen, Catherine, Breslin, Anne, Ahmad, Yasmeen, Emery, Paul, Matteson, E. L., Genovese, M., Sague, S., Hsia, E. C., Doyle, M. K., Fan, H., Elashoff, M., Kirkham, Bruce, Wasco, M. C., Bathon, J., Fleischmann, R., Genovese, M. C., Liu, H., Goldman, J., Leirisalo-Repo, M., Zanetakis, E., El-Kadi, H., Kellner, H., Bolce, R., Wang, J., Dehoratius, R., Decktor, D., Kremer, J., Taylor, Peter, Mendelsohn, A., Baker, D., Kim, L., Ritchlin, C., Mariette, Xavier, Matucci Cerenic, Marco, Pavelka, Karel, van Vollenhoven, Ronald, Heatley, Rebecca, Walsh, Claire, Lawson, Richard, Reynolds, Alan, Iaremenko, Oleg, Mikitenko, Ganna, Kavanaugh, Arthur, Luijtens, Kristel, Curtis, Jeffrey, Schiff, Michael, Kvien, Tore, Khanna, Dinesh, Furst, Dan, Behrens, Frank, Koehm, Michaela, Scharbatke, Eva C., Kleinert, Stefan, Weyer, Gerd, Tony, Hans-Peter, Burkhardt, Harald, Blunn, Karina J., Williams, Richard B., Young, Adam, McDowell, Jackie, Weinblatt, Michael, Haraoui, Boulos, Mozaffarian, Neelufar, Khraishi, Majed, Alten, Rieke, Gomez-Reino, Juan, Rizzo, Warren, Schechtman, Joy, Kahan, Andre, Vernon, Emma, Taylor, Monet, Hogan, Vanessa, Holweg, Cecile, Kummerfeld, Sarah, Teng, Onno, Townsend, Michael, van Laar, Jacob M., Gullick, Nicola J., De Silva, Chulanie, Kirkham, Bruce W., Roy, Sanjoy, Emery, P., van der Heijde, D., Keystone, E., Conaghan, P. G., Xu, W., Baratelle, A., Beutler, A., Rahman, M. U., Nikiphorou, Elena, Kiely, Patrick, Walsh, David A., Williams, Richard, Shah, Devron, Knight, Gregory D., Hutchinson, David G., Dass, Shouvik, Atzeni, Fabiola, Vital, Edward M., Bingham, Sarah J., Buch, Maya, Beirne, Paul, Fleischmann, Roy, Dougados, Maxime, Williams, Sarah, Reynard, Mark, Blackler, Laura, Zain, Amir, Oakley, Stephen, Rees, Jonathon, Jones, Tim, Mistlin, Alan, Panayi, Gabriel, Westhovens, Rene, Durez, Patrick, Genant, Harry, Robles, Manuel, Becker, Jean-Claude, Covucci, Allison, Bathon, Joan, Genovese, Mark C., Luggen, Michael, Le Bars, Manuela, Aranda, Richard, Li, Tracy, Elegbe, Ayanbola, Fichtner, Andreas, Strand, Vibeke, Vencovsky, Jiri, Davies, Rebecca, Galloway, James, Hochberg, Marc, Kelly, Sheila, Khan, Nadar, Qi, Keqin, Pappu, Ramesh, Delaet, Ingrid, Luo, Allison, Torbeyns, Anne, Moreland, Larry, Cohen, Roger, Gujrathi, Sheila, Bykerk, Vivian P., Álvaro-Gracia, Jose, Andres Roman Ivorra, Jose, Nurmohamed, Michael T., Bernasconi, Corrado, Stancati, Andrea, Sibilia, Jean, Östör, Andrew, Strangfeld, Anja, Eveslage, Maria, Listing, Joachim, Herzer, Peter, Liebhaber, Anke, Krummel-Lorenz, Brigitte, Zink, Angela, Breedveld, Ferdinand C., Cohen, Stanley B., Matteson, Eric L., Burke, Laura, Chai, Akiko, Reiss, William, Sweetser, Marianne, Shaw, Tim, Ellis, Shawn D., Ehrenstein, Michael R., Notley, Clare A., Yazici, Yusuf, Ince, Akgun, Baraf, Herbert, Malamet, Raymond, Chung, Carol Y., Hughes, Chris, Faurholm, Bjarne, Dell'Accio, Francesco, Manzo, Antonio, Seed, Michael, Eltawil, Noha, Marrelli, Alessandra, Gould, David, Subang, Christina, Al-Kashi, Adam, De Bari, Cosimo, Winyard, Paul, Chernajovsky, Yuti, Nissim, Ahuva, Bingham, Clifton, Fleischmann, Roy M., Furst, Daniel E., Macey, Katherine M., Sweetser, Marianne T., Lehane, Patricia, Farmer, Pamela, Long, Simon G., Kremer, Joel M., Burgos-Vargas, Ruben, Dudler, Jean, Mela, Christopher M., Wegner, Natalia, Lugli, Helena, Quirke, Anne-Marie, Guo, Yonghua, Potempa, Jan, Venables, Patrick, Nishikawa, Masataka, Owaki, Hajime, Fuji, Takeshi, Soliman, Moetaza M., Ashcroft, Darren M., Watson, Kath D., Lunt, Mark, Symmons, Deborah, Hyrich, Kimme L., Atkinson, Francesca, Malik, Saadia, Heycock, Carol, Saravanan, Vadivelu, Rynne, Martin, Hamilton, Jennifer, Kelly, Clive, Burmester, Gerd, Kary, Sonja, Unnebrink, Kristina, Guérette, Benoit, Oezer, Uemit, Kupper, Hartmut, Dennison, Elaine, Jameson, Karen, Hyrich, Kimme, Watson, Kath, Landewe, Robert, Keystone, Edward, Smolen, Josef, Goldring, Mary, Patra, Kaushik, Cifaldi, Mary, van der Heijde, Désirée, Lloyd, Lois A., Owen, Catherine, Breslin, Anne, Ahmad, Yasmeen, Emery, Paul, Matteson, E. L., Genovese, M., Sague, S., Hsia, E. C., Doyle, M. K., Fan, H., Elashoff, M., Kirkham, Bruce, Wasco, M. C., Bathon, J., Fleischmann, R., Genovese, M. C., Liu, H., Goldman, J., Leirisalo-Repo, M., Zanetakis, E., El-Kadi, H., Kellner, H., Bolce, R., Wang, J., Dehoratius, R., Decktor, D., Kremer, J., Taylor, Peter, Mendelsohn, A., Baker, D., Kim, L., Ritchlin, C., Mariette, Xavier, Matucci Cerenic, Marco, Pavelka, Karel, van Vollenhoven, Ronald, Heatley, Rebecca, Walsh, Claire, Lawson, Richard, Reynolds, Alan, Iaremenko, Oleg, Mikitenko, Ganna, Kavanaugh, Arthur, Luijtens, Kristel, Curtis, Jeffrey, Schiff, Michael, Kvien, Tore, Khanna, Dinesh, Furst, Dan, Behrens, Frank, Koehm, Michaela, Scharbatke, Eva C., Kleinert, Stefan, Weyer, Gerd, Tony, Hans-Peter, Burkhardt, Harald, Blunn, Karina J., Williams, Richard B., Young, Adam, McDowell, Jackie, Weinblatt, Michael, Haraoui, Boulos, Mozaffarian, Neelufar, Khraishi, Majed, Alten, Rieke, Gomez-Reino, Juan, Rizzo, Warren, Schechtman, Joy, Kahan, Andre, Vernon, Emma, Taylor, Monet, Hogan, Vanessa, Holweg, Cecile, Kummerfeld, Sarah, Teng, Onno, Townsend, Michael, van Laar, Jacob M., Gullick, Nicola J., De Silva, Chulanie, Kirkham, Bruce W., Roy, Sanjoy, Emery, P., van der Heijde, D., Keystone, E., Conaghan, P. G., Xu, W., Baratelle, A., Beutler, A., Rahman, M. U., Nikiphorou, Elena, Kiely, Patrick, Walsh, David A., Williams, Richard, Shah, Devron, Knight, Gregory D., Hutchinson, David G., Dass, Shouvik, Atzeni, Fabiola, Vital, Edward M., Bingham, Sarah J., Buch, Maya, Beirne, Paul, Fleischmann, Roy, Dougados, Maxime, Williams, Sarah, Reynard, Mark, Blackler, Laura, Zain, Amir, Oakley, Stephen, Rees, Jonathon, Jones, Tim, Mistlin, Alan, Panayi, Gabriel, Westhovens, Rene, Durez, Patrick, Genant, Harry, Robles, Manuel, Becker, Jean-Claude, Covucci, Allison, Bathon, Joan, Genovese, Mark C., Luggen, Michael, Le Bars, Manuela, Aranda, Richard, Li, Tracy, Elegbe, Ayanbola, Fichtner, Andreas, Strand, Vibeke, Vencovsky, Jiri, Davies, Rebecca, Galloway, James, Hochberg, Marc, Kelly, Sheila, Khan, Nadar, Qi, Keqin, Pappu, Ramesh, Delaet, Ingrid, Luo, Allison, Torbeyns, Anne, Moreland, Larry, Cohen, Roger, Gujrathi, Sheila, Bykerk, Vivian P., Álvaro-Gracia, Jose, Andres Roman Ivorra, Jose, Nurmohamed, Michael T., Bernasconi, Corrado, Stancati, Andrea, Sibilia, Jean, Östör, Andrew, Strangfeld, Anja, Eveslage, Maria, Listing, Joachim, Herzer, Peter, Liebhaber, Anke, Krummel-Lorenz, Brigitte, Zink, Angela, Breedveld, Ferdinand C., Cohen, Stanley B., Matteson, Eric L., Burke, Laura, Chai, Akiko, Reiss, William, Sweetser, Marianne, Shaw, Tim, Ellis, Shawn D., Ehrenstein, Michael R., Notley, Clare A., Yazici, Yusuf, Ince, Akgun, Baraf, Herbert, Malamet, Raymond, Chung, Carol Y., Hughes, Chris, Faurholm, Bjarne, Dell'Accio, Francesco, Manzo, Antonio, Seed, Michael, Eltawil, Noha, Marrelli, Alessandra, Gould, David, Subang, Christina, Al-Kashi, Adam, De Bari, Cosimo, Winyard, Paul, Chernajovsky, Yuti, Nissim, Ahuva, Bingham, Clifton, Fleischmann, Roy M., Furst, Daniel E., Macey, Katherine M., Sweetser, Marianne T., Lehane, Patricia, Farmer, Pamela, Long, Simon G., Kremer, Joel M., Burgos-Vargas, Ruben, Dudler, Jean, Mela, Christopher M., Wegner, Natalia, Lugli, Helena, Quirke, Anne-Marie, Guo, Yonghua, Potempa, Jan, and Venables, Patrick

Abstract

Background: In Japan, more than 20 rheumatoid arthritis (RA) patients died of interstitial pneumonia (IP) caused by leflunomide (LEF) were reported, but many of them were considered as the victims of opportunistic infection currently. In this paper, efficacy and safety of low-dose LEF classified by body weight (BW) were studied. Methods: Fifty-nine RA patients were started to administrate LEF from July 2007 to July 2009. Among them, 25 patients were excluded because of the combination with tacrolimus, and medication modification within 3 months before LEF. Remaining 34 RA patients administered 20 to 50 mg/week of LEF were followed up for 1 year and enrolled in this study. Dose of LEF was classified by BW (50 mg/week for over 50 kg, 40 mg/week for 40 to 50 kg and 20 to 30 mg/week for under 40 kg). The average age and RA duration of enrolled patients were 55.5 years old and 10.2 years. Prednisolone (PSL), methotrexate (MTX) and etanercept were used in 23, 28 and 2 patients, respectively. In case of insufficient response or adverse effect, dosage change or discontinuance of LEF were considered. Failure was defined as dosages up of PSL and MTX, or dosages down or discontinuance of LEF. Last observation carried forward method was used for the evaluation of failed patients at 1 year. Results: At 1 year after LEF start, good/ moderate/ no response assessed by the European League Against Rheumatism (EULAR) response criteria using Disease Activity Score, including a 28-joint count (DAS28)-C reactive protein (CRP) were showed in 14/ 10/ 10 patients, respectively. The dosage changes of LEF at 1 year were dosage up: 10, same dosage: 5, dosage down: 8 and discontinuance: 11 patients. The survival rate of patients in this study was 23.5% (24 patients failed) but actual LEF continuous rate was 67.6% (11 patients discontinued) at 1 year. The major reason of failure was liver dysfunction, and pneumocystis pneumonia was occurred in 1 patient resulted in full recovery. One patient die

Published
2017

44. Effectiveness of Different Dosages of Retreatment of Rituximab in Combination with Leflunomide: Results from a Multicenter Randomized Placebo Controlled Investigator Initiated Clinical Trial in Active Rheumatoid Arthritis (Amara-Study

Author

Behrens, Frank, Rossmanith, Tanja, Koehm, Michaela, Alten, Rieke, Aringer, Martin, Burmester, G. R., Feist, Eugen, Krueger, Klaus, Mueller-Ladner, Ulf, Rubbert-Roth, Andrea, Wassenberg, Siegfried, Tony, Hans-Peter, Kellner, Herbert, Backhaus, Marina, Burkhardt, Harald, Behrens, Frank, Rossmanith, Tanja, Koehm, Michaela, Alten, Rieke, Aringer, Martin, Burmester, G. R., Feist, Eugen, Krueger, Klaus, Mueller-Ladner, Ulf, Rubbert-Roth, Andrea, Wassenberg, Siegfried, Tony, Hans-Peter, Kellner, Herbert, Backhaus, Marina, and Burkhardt, Harald

Published
2016

50. Rheumatoid arthritis - treatment: 180. Utility of Body Weight Classified Low-Dose Leflunomide in Japanese Rheumatoid Arthritis

Author

Nishikawa, Masataka, Owaki, Hajime, Fuji, Takeshi, Soliman, Moetaza M., Ashcroft, Darren M., Watson, Kath D., Lunt, Mark, Symmons, Deborah, Hyrich, Kimme L., Atkinson, Francesca, Malik, Saadia, Heycock, Carol, Saravanan, Vadivelu, Rynne, Martin, Hamilton, Jennifer, Kelly, Clive, Burmester, Gerd, Kary, Sonja, Unnebrink, Kristina, Guérette, Benoit, Oezer, Uemit, Kupper, Hartmut, Dennison, Elaine, Jameson, Karen, Hyrich, Kimme, Watson, Kath, Landewe, Robert, Keystone, Edward, Smolen, Josef, Goldring, Mary, Patra, Kaushik, Cifaldi, Mary, van der Heijde, Désirée, Lloyd, Lois A., Owen, Catherine, Breslin, Anne, Ahmad, Yasmeen, Emery, Paul, Matteson, E. L., Genovese, M., Sague, S., Hsia, E. C., Doyle, M. K., Fan, H., Elashoff, M., Kirkham, Bruce, Wasco, M. C., Bathon, J., Fleischmann, R., Genovese, M. C., Liu, H., Goldman, J., Leirisalo-Repo, M., Zanetakis, E., El-Kadi, H., Kellner, H., Bolce, R., Wang, J., Dehoratius, R., Decktor, D., Kremer, J., Taylor, Peter, Mendelsohn, A., Baker, D., Kim, L., Ritchlin, C., Mariette, Xavier, Matucci Cerenic, Marco, Pavelka, Karel, van Vollenhoven, Ronald, Heatley, Rebecca, Walsh, Claire, Lawson, Richard, Reynolds, Alan, Iaremenko, Oleg, Mikitenko, Ganna, Kavanaugh, Arthur, Luijtens, Kristel, Curtis, Jeffrey, Schiff, Michael, Kvien, Tore, Khanna, Dinesh, Furst, Dan, Behrens, Frank, Koehm, Michaela, Scharbatke, Eva C., Kleinert, Stefan, Weyer, Gerd, Tony, Hans-Peter, Burkhardt, Harald, Blunn, Karina J., Williams, Richard B., Young, Adam, McDowell, Jackie, Weinblatt, Michael, Haraoui, Boulos, Mozaffarian, Neelufar, Khraishi, Majed, Alten, Rieke, Gomez-Reino, Juan, Rizzo, Warren, Schechtman, Joy, Kahan, Andre, Vernon, Emma, Taylor, Monet, Hogan, Vanessa, Holweg, Cecile, Kummerfeld, Sarah, Teng, Onno, Townsend, Michael, van Laar, Jacob M., Gullick, Nicola J., De Silva, Chulanie, Kirkham, Bruce W., Roy, Sanjoy, Emery, P., van der Heijde, D., Keystone, E., Conaghan, P. G., Xu, W., Baratelle, A., Beutler, A., Rahman, M. U., Nikiphorou, Elena, Kiely, Patrick, Walsh, David A., Williams, Richard, Shah, Devron, Knight, Gregory D., Hutchinson, David G., Dass, Shouvik, Atzeni, Fabiola, Vital, Edward M., Bingham, Sarah J., Buch, Maya, Beirne, Paul, Fleischmann, Roy, Dougados, Maxime, Williams, Sarah, Reynard, Mark, Blackler, Laura, Zain, Amir, Oakley, Stephen, Rees, Jonathon, Jones, Tim, Mistlin, Alan, Panayi, Gabriel, Westhovens, Rene, Durez, Patrick, Genant, Harry, Robles, Manuel, Becker, Jean-Claude, Covucci, Allison, Bathon, Joan, Genovese, Mark C., Luggen, Michael, Le Bars, Manuela, Aranda, Richard, Li, Tracy, Elegbe, Ayanbola, Fichtner, Andreas, Strand, Vibeke, Vencovsky, Jiri, Davies, Rebecca, Galloway, James, Hochberg, Marc, Kelly, Sheila, Khan, Nadar, Qi, Keqin, Pappu, Ramesh, Delaet, Ingrid, Luo, Allison, Torbeyns, Anne, Moreland, Larry, Cohen, Roger, Gujrathi, Sheila, Bykerk, Vivian P., Álvaro-Gracia, Jose, Andres Roman Ivorra, Jose, Nurmohamed, Michael T., Bernasconi, Corrado, Stancati, Andrea, Sibilia, Jean, Östör, Andrew, Strangfeld, Anja, Eveslage, Maria, Listing, Joachim, Herzer, Peter, Liebhaber, Anke, Krummel-Lorenz, Brigitte, Zink, Angela, Breedveld, Ferdinand C., Cohen, Stanley B., Matteson, Eric L., Burke, Laura, Chai, Akiko, Reiss, William, Sweetser, Marianne, Shaw, Tim, Ellis, Shawn D., Ehrenstein, Michael R., Notley, Clare A., Yazici, Yusuf, Ince, Akgun, Baraf, Herbert, Malamet, Raymond, Chung, Carol Y., Hughes, Chris, Faurholm, Bjarne, Dell'Accio, Francesco, Manzo, Antonio, Seed, Michael, Eltawil, Noha, Marrelli, Alessandra, Gould, David, Subang, Christina, Al-Kashi, Adam, De Bari, Cosimo, Winyard, Paul, Chernajovsky, Yuti, Nissim, Ahuva, Bingham, Clifton, Fleischmann, Roy M., Furst, Daniel E., Macey, Katherine M., Sweetser, Marianne T., Lehane, Patricia, Farmer, Pamela, Long, Simon G., Kremer, Joel M., Burgos-Vargas, Ruben, Dudler, Jean, Mela, Christopher M., Wegner, Natalia, Lugli, Helena, Quirke, Anne-Marie, Guo, Yonghua, Potempa, Jan, Venables, Patrick, Nishikawa, Masataka, Owaki, Hajime, Fuji, Takeshi, Soliman, Moetaza M., Ashcroft, Darren M., Watson, Kath D., Lunt, Mark, Symmons, Deborah, Hyrich, Kimme L., Atkinson, Francesca, Malik, Saadia, Heycock, Carol, Saravanan, Vadivelu, Rynne, Martin, Hamilton, Jennifer, Kelly, Clive, Burmester, Gerd, Kary, Sonja, Unnebrink, Kristina, Guérette, Benoit, Oezer, Uemit, Kupper, Hartmut, Dennison, Elaine, Jameson, Karen, Hyrich, Kimme, Watson, Kath, Landewe, Robert, Keystone, Edward, Smolen, Josef, Goldring, Mary, Patra, Kaushik, Cifaldi, Mary, van der Heijde, Désirée, Lloyd, Lois A., Owen, Catherine, Breslin, Anne, Ahmad, Yasmeen, Emery, Paul, Matteson, E. L., Genovese, M., Sague, S., Hsia, E. C., Doyle, M. K., Fan, H., Elashoff, M., Kirkham, Bruce, Wasco, M. C., Bathon, J., Fleischmann, R., Genovese, M. C., Liu, H., Goldman, J., Leirisalo-Repo, M., Zanetakis, E., El-Kadi, H., Kellner, H., Bolce, R., Wang, J., Dehoratius, R., Decktor, D., Kremer, J., Taylor, Peter, Mendelsohn, A., Baker, D., Kim, L., Ritchlin, C., Mariette, Xavier, Matucci Cerenic, Marco, Pavelka, Karel, van Vollenhoven, Ronald, Heatley, Rebecca, Walsh, Claire, Lawson, Richard, Reynolds, Alan, Iaremenko, Oleg, Mikitenko, Ganna, Kavanaugh, Arthur, Luijtens, Kristel, Curtis, Jeffrey, Schiff, Michael, Kvien, Tore, Khanna, Dinesh, Furst, Dan, Behrens, Frank, Koehm, Michaela, Scharbatke, Eva C., Kleinert, Stefan, Weyer, Gerd, Tony, Hans-Peter, Burkhardt, Harald, Blunn, Karina J., Williams, Richard B., Young, Adam, McDowell, Jackie, Weinblatt, Michael, Haraoui, Boulos, Mozaffarian, Neelufar, Khraishi, Majed, Alten, Rieke, Gomez-Reino, Juan, Rizzo, Warren, Schechtman, Joy, Kahan, Andre, Vernon, Emma, Taylor, Monet, Hogan, Vanessa, Holweg, Cecile, Kummerfeld, Sarah, Teng, Onno, Townsend, Michael, van Laar, Jacob M., Gullick, Nicola J., De Silva, Chulanie, Kirkham, Bruce W., Roy, Sanjoy, Emery, P., van der Heijde, D., Keystone, E., Conaghan, P. G., Xu, W., Baratelle, A., Beutler, A., Rahman, M. U., Nikiphorou, Elena, Kiely, Patrick, Walsh, David A., Williams, Richard, Shah, Devron, Knight, Gregory D., Hutchinson, David G., Dass, Shouvik, Atzeni, Fabiola, Vital, Edward M., Bingham, Sarah J., Buch, Maya, Beirne, Paul, Fleischmann, Roy, Dougados, Maxime, Williams, Sarah, Reynard, Mark, Blackler, Laura, Zain, Amir, Oakley, Stephen, Rees, Jonathon, Jones, Tim, Mistlin, Alan, Panayi, Gabriel, Westhovens, Rene, Durez, Patrick, Genant, Harry, Robles, Manuel, Becker, Jean-Claude, Covucci, Allison, Bathon, Joan, Genovese, Mark C., Luggen, Michael, Le Bars, Manuela, Aranda, Richard, Li, Tracy, Elegbe, Ayanbola, Fichtner, Andreas, Strand, Vibeke, Vencovsky, Jiri, Davies, Rebecca, Galloway, James, Hochberg, Marc, Kelly, Sheila, Khan, Nadar, Qi, Keqin, Pappu, Ramesh, Delaet, Ingrid, Luo, Allison, Torbeyns, Anne, Moreland, Larry, Cohen, Roger, Gujrathi, Sheila, Bykerk, Vivian P., Álvaro-Gracia, Jose, Andres Roman Ivorra, Jose, Nurmohamed, Michael T., Bernasconi, Corrado, Stancati, Andrea, Sibilia, Jean, Östör, Andrew, Strangfeld, Anja, Eveslage, Maria, Listing, Joachim, Herzer, Peter, Liebhaber, Anke, Krummel-Lorenz, Brigitte, Zink, Angela, Breedveld, Ferdinand C., Cohen, Stanley B., Matteson, Eric L., Burke, Laura, Chai, Akiko, Reiss, William, Sweetser, Marianne, Shaw, Tim, Ellis, Shawn D., Ehrenstein, Michael R., Notley, Clare A., Yazici, Yusuf, Ince, Akgun, Baraf, Herbert, Malamet, Raymond, Chung, Carol Y., Hughes, Chris, Faurholm, Bjarne, Dell'Accio, Francesco, Manzo, Antonio, Seed, Michael, Eltawil, Noha, Marrelli, Alessandra, Gould, David, Subang, Christina, Al-Kashi, Adam, De Bari, Cosimo, Winyard, Paul, Chernajovsky, Yuti, Nissim, Ahuva, Bingham, Clifton, Fleischmann, Roy M., Furst, Daniel E., Macey, Katherine M., Sweetser, Marianne T., Lehane, Patricia, Farmer, Pamela, Long, Simon G., Kremer, Joel M., Burgos-Vargas, Ruben, Dudler, Jean, Mela, Christopher M., Wegner, Natalia, Lugli, Helena, Quirke, Anne-Marie, Guo, Yonghua, Potempa, Jan, and Venables, Patrick

Abstract

Background: In Japan, more than 20 rheumatoid arthritis (RA) patients died of interstitial pneumonia (IP) caused by leflunomide (LEF) were reported, but many of them were considered as the victims of opportunistic infection currently. In this paper, efficacy and safety of low-dose LEF classified by body weight (BW) were studied. Methods: Fifty-nine RA patients were started to administrate LEF from July 2007 to July 2009. Among them, 25 patients were excluded because of the combination with tacrolimus, and medication modification within 3 months before LEF. Remaining 34 RA patients administered 20 to 50 mg/week of LEF were followed up for 1 year and enrolled in this study. Dose of LEF was classified by BW (50 mg/week for over 50 kg, 40 mg/week for 40 to 50 kg and 20 to 30 mg/week for under 40 kg). The average age and RA duration of enrolled patients were 55.5 years old and 10.2 years. Prednisolone (PSL), methotrexate (MTX) and etanercept were used in 23, 28 and 2 patients, respectively. In case of insufficient response or adverse effect, dosage change or discontinuance of LEF were considered. Failure was defined as dosages up of PSL and MTX, or dosages down or discontinuance of LEF. Last observation carried forward method was used for the evaluation of failed patients at 1 year. Results: At 1 year after LEF start, good/ moderate/ no response assessed by the European League Against Rheumatism (EULAR) response criteria using Disease Activity Score, including a 28-joint count (DAS28)-C reactive protein (CRP) were showed in 14/ 10/ 10 patients, respectively. The dosage changes of LEF at 1 year were dosage up: 10, same dosage: 5, dosage down: 8 and discontinuance: 11 patients. The survival rate of patients in this study was 23.5% (24 patients failed) but actual LEF continuous rate was 67.6% (11 patients discontinued) at 1 year. The major reason of failure was liver dysfunction, and pneumocystis pneumonia was occurred in 1 patient resulted in full recovery. One patient die

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