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16. Evaluation on the Sex-Specific Association Between Cigarette Smoke Exposure and Inflammation Markers—C-Reactive Protein and White Blood Cell Count.

Author

Koh, Dong-Hee, Choi, Sangjun, Park, Ju-Hyun, Lee, Sang-Gil, Kim, Hwan-Cheol, Kim, Inah, and Park, Dong-Uk

Abstract

Introduction Cigarette smoke increases peripheral white blood cell (WBC) count. However, the dose-dependent association between smoking and C-reactive protein (CRP), an important inflammatory marker, has been reported as inconsistent. Aims and Methods Here, we evaluated the associations between smoking and CRP using both smoking questionnaires and urine cotinine as exposure markers. The Korea National Health and Nutrition Examination Survey data were used for analyzing the associations. Multiple regression analyses were performed to examine the associations between cigarette smoke exposure, as assessed by questionnaires and urine cotinine, and health effects, as measured by CRP and WBC count, controlling for potential confounders. The confounders, including age, sex, body mass index, blood pressure, cholesterol, glucose, alanine aminotransferase, and uric acid, were selected a priori based on the literature. Results A total of 11 435 participants were included for analysis. For the exposure-response relationship, the results indicated a significant increase in CRP levels in male smokers compared to male nonsmokers (p  = .002), whereas no significant increase was found in female smokers compared to female nonsmokers (p  = .680). For the dose–response relationship, a significant positive association was observed between urine cotinine and CRP in male smokers (p  = .018), whereas no significant association was found in female smokers (p  = .508). WBC count consistently showed significant exposure-response and dose–response relationships in both sexes. Conclusions WBC count was found to be a consistent effect marker of cigarette smoke exposure, while the association between CRP level and smoking was inconsistent and varied by sex. The sex-specific response to cigarette smoke exposure warrants further exploration in future studies. Implications Cigarette smoke exposure is known to increase inflammation and has been thought to increase CRP, a significant inflammation marker. However, recent studies have reported conflicting results regarding the dose-dependent association between cigarette smoke exposure and CRP. This study found that the association between smoking and CRP is inconsistent and varies by sex, showing significant exposure response in men but not in women. Furthermore, the study suggests that WBC count is a more consistent marker for cigarette smoke exposure. [ABSTRACT FROM AUTHOR]

Published
2024
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45. Cholecystectomy Increases the Risk of type 2 Diabetes in the Korean Population: Data from the National Health Insurance Cooperation Health Checkup 2010-2017

Author

Huh, Ji Hye, primary, Lee, Kyong Joo, additional, Cho, Yun Kyung, additional, Moon, Shinje, additional, Kim, Yoon Jung, additional, Roh, Eun, additional, Han, Kyung-do, additional, Koh, Dong Hee, additional, Kang, Jun Goo, additional, Lee, Seong Jin, additional, and Ihm, Sung-Hee, additional

Published
2022
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48. EUS‐guided tissue acquisition using a novel torque technique is comparable with that of the fanning technique for solid pancreatic lesions: A multicenter randomized trial.

Author

Yang, Min Jae, Park, Se Woo, Lee, Kyong Joo, Koh, Dong Hee, Lee, Jin, Lee, Yun Nah, Park, Chan Hyuk, Shin, Eun, and Kim, Seokhwi

Abstract

Background: The torque and fanning techniques allow for multiple areas within pancreatic lesions to be targeted using different maneuvers and can, hence, enhance diagnostic outcomes. We compared the diagnostic performance of endoscopic ultrasound‐guided fine‐needle biopsy (EUS‐FNB) for pancreatic masses using the torque and fanning techniques. Methods: This multicenter randomized trial enrolled a total of 160 consecutive patients who underwent EUS‐FNB for solid pancreatic tumors using either the torque or fanning technique. Three passes were permitted for each lesion, and the technique sequence was randomly assigned as either torque first or fanning first with the standard technique as a reference. Results: The median quality score of the histological samples was significantly higher in the torque and fanning group than in the standard group (p <.001). Furthermore, the torque technique provided improved sensitivity of 93.38% and accuracy of 94.30%. The standard technique provided diagnostic sensitivity of 68.84% and accuracy of 72.96%, while the fanning technique showed sensitivity of 91.85% and accuracy of 93.04%. Conclusions: The new torque technique enables the acquisition of better‐quality samples and can potentially increase the diagnostic outcomes in the EUS‐FNB of pancreatic solid masses, with the same recommendations as those for the fanning technique. [ABSTRACT FROM AUTHOR]

Published
2023
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