2,980 results on '"Koh, J"'
Search Results
2. Low vaporization enthalpy of modified chitosan hydrogel for high performance solar evaporator
- Author
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Anukunwithaya, Patsaya, Liu, Nanxue, Liu, Siqi, Thanayupong, Eknarin, Zhou, Lili, Pimpha, Nuttaporn, Min, Jiakang, Chinsirikul, Wannee, Thitsartarn, Warintorn, Koh, J. Justin, and He, Chaobin
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- 2024
- Full Text
- View/download PDF
3. 3D-printed biomimetic structures for energy and environmental applications
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Li, Jiaming, Li, Mengli, Koh, J. Justin, Wang, John, and Lyu, Zhiyang
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- 2024
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4. Recycling Excavated Clay to Produce ‘Sand-Like’ Material Through Sintering: Static Furnace Versus Rotary Kiln
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Subramanian, S., Koh, J. W., Soh, J. M., Chew, S. H., Chua, K. E., Tan, Y. C., Teo, C. S., Koh, M. Y. C., Cheung, T. H. H., di Prisco, Marco, Series Editor, Chen, Sheng-Hong, Series Editor, Vayas, Ioannis, Series Editor, Kumar Shukla, Sanjay, Series Editor, Sharma, Anuj, Series Editor, Kumar, Nagesh, Series Editor, Wang, Chien Ming, Series Editor, Yukselen-Aksoy, Yeliz, editor, Reddy, Krishna R., editor, and Agnihotri, Arvind Kumar, editor
- Published
- 2023
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5. MIL-53(Al) assisted in upcycling plastic bottle waste into nitrogen-doped hierarchical porous carbon for high-performance supercapacitors
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Xu, Xiaodong, Li, Jiaxin, Dymerska, Anna, Koh, J. Justin, Min, Jiakang, Liu, Siqi, Azadmanjiri, Jalal, and Mijowska, Ewa
- Published
- 2023
- Full Text
- View/download PDF
6. One-pot synthesis of Pt@TiO2 core-shell nanoparticles for stable hydrogen evolution reaction in acidic and alkaline media
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Cho, S., Yim, G., Koh, J., Jang, H., and Park, J.T.
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- 2023
- Full Text
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7. Structural and conformable designs for aqueous multifunctional batteries
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Lim, Gwendolyn J.H., Chua, Rodney, Koh, J. Justin, Chan, Kwok Kiong, Tang, Ernest Jun Jie, Teh, Vanessa, and Srinivasan, Madhavi
- Published
- 2023
- Full Text
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8. Presence, origins and effect of stable surface hydration on regenerated cellulose for underwater oil-repellent membranes
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Justin Koh, J., Pang, Pengfei, Chakraborty, Souvik, Kong, Junhua, Sng, Anqi, Anukunwithaya, Patsaya, Huang, Shujuan, Koh, Xue Qi, Thenarianto, Calvin, Thitsartan, Warintorn, Daniel, Dan, and He, Chaobin
- Published
- 2023
- Full Text
- View/download PDF
9. Evaluating Knowledge to Support Climate Action: A Framework for Sustained Assessment Evaluating Knowledge to Support Climate Action: A Framework for Sustained Assessment
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Moss, RH, Avery, S, Baja, K, Burkett, M, William, S, Chischilly, AM, Dell, J, Fleming, PA, Geil, K, Jacobs, K, Jones, A, Knowlton, K, Koh, J, Lemos, MC, Melillo, J, Pandya, R, Richmond, TC, Scarlett, L, Snyder, J, Stults, M, Waple, A, Whitehead, J, Zarrilli, D, Ayyub, B, Fox, J, Ganguly, A, Joppa, L, Julius, S, Kirshen, P, Kreutter, R, McGovern, A, Meyer, R, Neumann, J, Solecki, W, Smith, J, Tissot, P, Yohe, G, and Zimmerman, R
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Climate Action ,North America ,Climate prediction ,Planning ,Policy ,Risk assessment ,Societal impacts - Abstract
As states, cities, tribes, and private interests cope with climate damages and seek to increase preparedness and resilience, they will need to navigate myriad choices and options available to them. Making these choices in ways that identify pathways for climate action that support their development objectives will require constructive public dialogue, community participation, and flexible and ongoing access to science- and experience-based knowledge. In 2016, a Federal Advisory Committee (FAC) was convened to recommend how to conduct a sustained National Climate Assessment (NCA) to increase the relevance and usability of assessments for informing action. The FAC was disbanded in 2017, but members and additional experts reconvened to complete the report that is presented here. A key recommendation is establishing a new nonfederal ‘‘climate assessment consortium’’ to increase the role of state/local/tribal government and civil society in assessments. The expanded process would 1) focus on applied problems faced by practitioners, 2) organize sustained partnerships for collaborative learning across similar projects and case studies to identify effective tested practices, and 3) assess and improve knowledge-based methods for project implementation. Specific recommendations include evaluating climate models and data using user-defined metrics; improving benefit–cost assessment and supporting decision-making under uncertainty; and accelerating application of tools and methods such as citizen science, artificial intelligence, indicators, and geospatial analysis. The recommendations are the result of broad consultation and present an ambitious agenda for federal agencies, state/local/tribal jurisdictions, universities and the research sector, professional associations, nongovernmental and community-based organizations, and private-sector firms.
- Published
- 2019
10. A framework for sustained climate assessment in the United States
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Moss, RH, Avery, S, Baja, K, Burkett, M, Chischilly, AM, Dell, J, Fleming, PA, Geil, K, Jacobs, K, Jones, A, Knowlton, K, Koh, J, Lemos, MC, Melillo, J, Pandya, R, Richmond, TC, Scarlett, L, Snyder, J, Stults, M, Waple, A, Whitehead, J, Zarrilli, D, Fox, J, Ganguly, A, Joppa, L, Julius, S, Kirshen, P, Kreutter, R, McGovern, A, Meyer, R, Neumann, J, Solecki, W, Smith, J, Tissot, P, Yohe, G, and Zimmerman, R
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Astronomical and Space Sciences ,Atmospheric Sciences ,Physical Geography and Environmental Geoscience ,Meteorology & Atmospheric Sciences ,Atmospheric sciences ,Climate change science - Published
- 2019
11. Diverse-shaped tin dioxide nanoparticles within a plastic waste-derived three-dimensional porous carbon framework for super stable lithium-ion storage
- Author
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Min, Jiakang, Xu, Xiaodong, Koh, J. Justin, Gong, Jiang, Chen, Xuecheng, Azadmanjiri, Jalal, Zhang, Feifei, Liu, Siqi, and He, Chaobin
- Published
- 2022
- Full Text
- View/download PDF
12. Evaluating knowledge to support climate action: A framework for sustained assessment. Report of an independent advisory committee on applied climate assessment
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Moss, RH, Avery, S, Baja, K, Burkett, M, Chischilly, AM, Dell, J, Fleming, PA, Geil, K, Jacobs, K, Jones, A, Knowlton, K, Koh, J, Lemos, MC, Melillo, J, Pandya, R, Richmond, TC, Scarlett, L, Snyder, J, Stults, M, Waple, AM, Whitehead, J, Zarrilli, D, Ayyub, BM, Fox, J, Ganguly, A, Joppa, L, Julius, S, Kirshen, P, Kreutter, R, McGovern, A, Meyer, R, Neumann, J, Solecki, W, Smith, J, Tissot, P, Yohe, G, and Zimmerman, R
- Subjects
North America ,Climate prediction ,Planning ,Policy ,Risk assessment ,Societal impacts ,MD Multidisciplinary - Abstract
As states, cities, tribes, and private interests cope with climate damages and seek to increase preparedness and resilience, they will need to navigate myriad choices and options available to them. Making these choices in ways that identify pathways for climate action that support their development objectives will require constructive public dialogue, community participation, and flexible and ongoing access to science- and experience-based knowledge. In 2016, a Federal Advisory Committee (FAC) was convened to recommend how to conduct a sustained National Climate Assessment (NCA) to increase the relevance and usability of assessments for informing action. The FAC was disbanded in 2017, but members and additional experts reconvened to complete the report that is presented here. A key recommendation is establishing a new nonfederal ‘‘climate assessment consortium’’ to increase the role of state/local/tribal government and civil society in assessments. The expanded process would 1) focus on applied problems faced by practitioners, 2) organize sustained partnerships for collaborative learning across similar projects and case studies to identify effective tested practices, and 3) assess and improve knowledge-based methods for project implementation. Specific recommendations include evaluating climate models and data using user-defined metrics; improving benefit–cost assessment and supporting decision-making under uncertainty; and accelerating application of tools and methods such as citizen science, artificial intelligence, indicators, and geospatial analysis. The recommendations are the result of broad consultation and present an ambitious agenda for federal agencies, state/local/tribal jurisdictions, universities and the research sector, professional associations, nongovernmental and community-based organizations, and private-sector firms.
- Published
- 2019
13. AB0853 THE LONG-TERM OUTCOME OF RENAL INVOLVEMENT IN PRIMARY SJOGREN’S SYNDROME
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Kim, W. U., primary, Koh, J. H., additional, Park, Y., additional, Jeon, H., additional, and Suh, Y. S., additional
- Published
- 2024
- Full Text
- View/download PDF
14. Construction of a hierarchical multiscale conducting network for enhanced thermoelectric response in organic PEDOT:PSS based nanocomposites
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Zhang, Yong, Liu, Siqi, Koh, J. Justin, and He, Chaobin
- Published
- 2021
- Full Text
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15. Robust, 3D-printed hydratable plastics for effective solar desalination
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Koh, J. Justin, Lim, Gwendolyn J.H., Chakraborty, Souvik, Zhang, Yaoxin, Liu, Siqi, Zhang, Xiwen, Tan, Swee Ching, Lyu, Zhiyang, Ding, Jun, and He, Chaobin
- Published
- 2021
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16. Acceleration of HDL-Mediated Cholesterol Efflux Alleviates Periodontitis.
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Tran, T.-T., Lee, G., Huh, Y.H., Chung, K.-H., Lee, S.Y., Park, K.H., Kim, J.-H., Kook, M.-S., Ryu, J., Kim, O.-S., Lim, H.-P., Koh, J.-T., and Ryu, J.-H.
- Subjects
HDL cholesterol ,HIGH cholesterol diet ,BONE resorption ,APOLIPOPROTEIN A ,LOGISTIC regression analysis - Abstract
Periodontitis (PD) is a common inflammatory disease known to be closely associated with metabolic disorders, particularly hyperlipidemia. In the current study, we demonstrated that hypercholesterolemia is a predisposing factor in the development of PD. Logistic regression analysis revealed a strong positive correlation between PD and dyslipidemia. Data from in vivo (PD mouse model subjected to a high cholesterol diet) and in vitro (cholesterol treatment of gingival fibroblasts [GFs]) experiments showed that excess cholesterol influx into GFs potentially contributes to periodontal inflammation and, subsequently, alveolar bone erosion. Additionally, we compared the protective efficacies of cholesterol-lowering drugs with their different modes of action against PD pathogenesis in mice. Among the cholesterol-lowering drugs we tested, fenofibrate exerted the most protective effect against PD pathogenesis due to an increased level of high-density lipoprotein cholesterol, a lipoprotein involved in cholesterol efflux from cells and reverse cholesterol transport. Indeed, cholesterol efflux was suppressed during PD progression by downregulation of the apoA-I binding protein (APOA1BP) expression in inflamed GFs. We also demonstrated that the overexpression of APOA1BP efficiently regulated periodontal inflammation and the subsequent alveolar bone loss by inducing cholesterol efflux. Our collective findings highlight the potential utility of currently available cholesterol-lowering medications for the mitigation of PD pathogenesis. By targeting the acceleration of high-density lipoprotein-mediated cellular cholesterol efflux, a new therapeutic approach for PD may become possible. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
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17. Reprogrammable, Sustainable, and 3D‐Printable Cellulose Hydroplastic
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Koh, J. Justin, primary, Koh, Xue Qi, additional, Chee, Jing Yee, additional, Chakraborty, Souvik, additional, Tee, Si Yin, additional, Zhang, Danwei, additional, Lai, Szu Cheng, additional, Yeo, Jayven Chee Chuan, additional, Soh, Jia Wen Jaslin, additional, Li, Peiyu, additional, Tan, Swee Ching, additional, Thitsartarn, Warintorn, additional, and He, Chaobin, additional
- Published
- 2024
- Full Text
- View/download PDF
18. Convection‐Permitting Climate Models Can Support Observations to Generate Rainfall Return Levels
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Poschlod, B., primary and Koh, J., additional
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- 2024
- Full Text
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19. Evaluating Knowledge to Support Climate Action : Framework for Sustained Assessment. Report of an Independent Advisory Committee on Applied Climate Assessment
- Author
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Moss, R. H., Avery, S., Baja, K., Burkett, M., Chischilly, A. M., Dell, J., Fleming, P. A., Geil, K., Jacobs, K., Jones, A., Knowlton, K., Koh, J., Lemos, M. C., Melillo, J., Pandya, R., Richmond, T. C., Scarlett, L., Snyder, J., Stults, M., Waple, A. M., Whitehead, J., Zarrilli, D., Ayyub, B. M., Fox, J., Ganguly, A., Joppa, L., Julius, S., Kirshen, P., Kreutter, R., Mcgovern, A., Meyer, R., Neumann, J., Solecki, W., Smith, J., Tissot, P., Yohe, G., and Zimmerman, R.
- Published
- 2019
20. Evaluation of a quality improvement intervention to reduce anastomotic leak following right colectomy (EAGLE): pragmatic, batched stepped-wedge, cluster-randomized trial in 64 countries
- Author
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Bengueddach, A., Tidjane, A., Tabeti, B., Behilil, C., Boudjenan-Serradj, N., Bensafir, S., Meharzi, S. E. I., Aissat, A., Ghouali, A. K., Larabi, K., Riffi, O., Kacimi, S. E. O., Mesli, S. N., Rezoug, W., Mitidieri, A., Jose, A., Pablo, C., Rodriguez, C. A., Panettiere, M. F., Barbalace, N., Juan, T., Lucena, J., Houdin, A., Fernandez, E., Lococo, J., Pedro, L., Loban, M., Vecchio, P., Grinblat, A., Carrie, A., Veracierto, F., Santillan, M., Napolitano, M., Avellaneda, N., Rosa, S. L., Gonzalez, C. M., Ferro, E., Munoz, J. P., Ventorutti, T., Cabrera, C., Carrizo, C., Mospane, C., Leiro, F., Espino, J., Trama, M., Bianchi, R., Potolicchio, A., Dindri, F., Buey, L., Lucas, N., Catalano, P., Astilleta, R., Quiroga, Y., Chwat, C., Valli, D., Alexandre, F., Martres, G., Rosato, G., Lemme, G., Romero, V., Doniquian, A. M., Pachajoa, D. A. P., Llahi, F., Fiorenza, J. M., Parodi, M., Ocana, N., Gallardo, A., Valenzuela, A., Perriello, J., Nador, R., Fermani, C., Garay, L., Blanco, P., Villalobos, S., Posner, F., Vieyra, N., Fiorito, P., Ciabattari, P., Kort, C. D., Daryanani, D., Smit, J., Gosselink, M. P., Janssen, N., Feiss, A., Lee, C. H. A., Taylor, D., Edington, J., Chen, N., Ong, W. M., Aigner, F., Moitzi, G., Gemes, G., Braumille, M., Mitteregger, M., Gerald, S., Uranitsch, S., Belarmino, A., Waha, J., Kahn, J., Treiber, M., Schemmer, P., Mikalauskas, S., Ibrahimli, A., Samadov, E., Orujova, E., Namazov, I., Alikhanli, J., Asgarov, M., Kutkut, A., Almahmeed, E., Aljawder, H., Juma, I., Johnston, K., Saeed, M. F., Khairi, S., Matovic, E., Omerasevic, M., Delibegovic, S., Hodzic, S., Rudell, A. G., Fuzari, J., Farah, J. F., Nadal, L. R. M., Dos Santos, M. B. A., Lupinacci, R. A., Pereira, T. S., Sete, A. D. S., Filho, A. L., De Souza Pires, B. L., Queiroz, F. L. D., Amaral, H. A. T., Dos Santos, M. A. M., De Miranda Silvestre, S. C., Hanan, B., Reis, C., Cassia, G., Luz, M. D., Delgado, M., Campanati, R., Silva, R., Bomfa-Barbosa, A., Alves, B. C., Costa, B. X. M., Cortes, B. G. W., Lemos, F. H. T., Arreguy-Borges, K., Silva, T. B., Assis, A., Freitas, A. H., Rezende, D., Silva, H., Alvarenga, I., Cascais, R., Silva, T., Santos, G., Pinto, H., Silva, I., Leite, L., Massahud, M., Meyer, M., Tiburcio, R., Martinez, C. A. R., Espinha, D. R., Marson, F. A. L., De Oliveira Goes, I. A., De Souza Artioli, L. M., Boschiero, M. N., Takahashi, C. Y., Oliveira, F. G. D., Lyra, H. F., De Oliveira, J. C. C., Santos, J. M. D., Gerber, M. T., Erdmann, T. R., Barbosa, A., Fernandes, A., Junior, A. N., Junior, H. M., Moreira, J., Ribeiro, M., Moreira, P., Carvalho, A., Santos, B., Fidelis, F., Cruz, I., Codes, L., Aibe, R., Boudoux, S., Favacho, B. C., Pinto, F., Gava, G., Pivati, I. R., Vilain, L. F., Kim, N., Nunes, R. L., Dimitrov, D., Peneva, K., Karamanliev, M., Dimitrova, S., Ivanov, T., Atanasov, B., Dzharov, G., Shtereva, M., Slavchev, M., Belev, N., Krastev, P., Arabadzhiev, A., Tonova, D., Tzoneva, D., Sokolov, M., Gribnev, P., Maslyankov, S., Pavlov, V., Bakmaz, B., Dijan, E., Coza, I., Mihanovic, J., Kucic, J., Sulen, N., Katusic, Z., Hudacek, K., Farkasova, M., Markova, M., Grolich, T., Kala, Z., Pazdirek, F., Hoch, J., Filipova, L., Kocian, P., Prikryl, P., Hogn, A., Moller, B., Slot, D. K., Baelum, J. K., Cour, K. L., Ellebaek, M. B., Eriksen, N. D., Mahmoud, A., Abdellatif, A., Nafea, A., Ewedah, M., Soliman, M., Yakout, N., Argawy, O., Sallam, I., Kamel, I., Sherif, M., Ashmawy, S., Ali, A., Saad, M., Ahmed, M., Mohamed, M., Mohamed, N., Mahmoud, S., Rashed, A. M., Abd-Errazik, M. A., Ammar, M. A., Mohammed, R., Ebrahem, A., Aal, A. A. E., Abdou, K., Wagdy, M., Qassem, M., Taha, M., El-Wafa, Y. A., Shehta, A., Metwally, A. E., Hamed, H., Ali, M. A., Elrefai, M., Sorogy, M. E., Abdelkhalek, M., Ragab, A., Refky, B., Metwally, I. H., Kamal, M., Zuhdy, M., Shetiwy, M., Sakr, A., Elfallal, A., Elfeki, H., Eldakroury, I., Elbahrawy, K., Mostafa, M., Emile, S., Tessema, A., Tasew, A., Gezahegn, H., Bekele, K., Belay, M., Gudisa, Z., Teferu, Z., Vayrynen, A., Kechagias, A., Turunen, A., Katunin, J., Parhiala, M., Pengerma, P., Lahti, P., Carpelan, A., Vihervaara, H., Huhtinen, H., Pasonen, J., Heino, R., Pakarinen, S., Falenius, V., Pinard, B., Nobile, C., Duchalais, E., Drissi, F., Meurette, G., Podevin, J., Lepenndu, M., Hoetzel, A., Jud, A., Jauch, D., Stefan, F. -F., Neeff, H., Holzner, P., Nguyen, P., Ryl, A., Kehl, F., Pullig, F., Baral, J., Munch, S., Futterer, C., Reissfelder, C., Sandra-Petrescu, F., Herrle, F., Hardt, J., Lamm, L., Seyfried, S., Gharbi, A., Aydin, F., Stavrou, G., Sperber, J., Deken, J. D., Schwarzkopf, K., Widyaningsih, R., Polidorou, A., Mpakas, A., Tokidis, E., Loun, L., Petropoulou, T., Balalis, D., Korkolis, D., Manatakis, D., Assimakopoulou, E., Bourazani, M., Gklavas, A., Kalamara, E., Papaconstantinou, I., Theodoraki, K., Chardalias, L., Konstadoulakis, M., Theodosopoulos, T., Soulioti, E., Kavezou, F., Filippou, J., Papadoliopoulou, M., Michalopoulos, N., Vassiliu, P., Sidiropoulos, T., Charakopoulou, A., Panagiotou, A., Bouchagier, K., Kokkinakis, K., Lambridi, E., Psarologos, M., Maria, S., Giannaraki, S., Kapiris, S., Triantafyllou, A., Theodoropoulos, C., Matthaiou, G., Westzaan, N., Etelka, S., Triantafyllou, T., Schizas, D., Mpaili, E., Karydakis, L., Mpoura, M., Danassi, D., Karavokyros, I., Dimitriou, N., Livanou, X., Kikira, A., Tsourouflis, G., Tomara, N. -K., Nikiteas, N., Dorovinis, P., Garoufalia, Z., Tsiotos, G., Stamou, K., Kocka, N., Ballian, N., Kalakonas, S., Athanasakis, E., Chrysos, E., Xynos, E., Tsiaoussis, J., Papadaki, K., Xenaki, S., Nyktari, V., Sarakatsianou, C., Bompou, E., Arnaoutoglou, E., Tzovaras, G., Baloyiannis, I., Mamaloudis, I., Perivoliotis, K., Apostolidi, E., Mulita, F., Karpetas, G., Maroulis, I., Vailas, M., Petra, A., Kontis, E., Kaouras, E., Katsaros, I., Katsiaras, L., Manikis, P., Papadopoulou, T., Papadopoulos, A., Manioti, E., Zeringa, G., Katsinelis, I., Mouzakis, O., Kouki, P., Nikolaou, V., Marinis, A., Alexopoulou, K., Papadaki, M., Vederaki, S. -A., Samara, A., Giakoustidis, D., Christodoulidis, G., Bareka, M., Chatzikomnitsa, P., Tsigara, S., Papadopoulos, V., Zarzava, E., Anestiadou, E., Lydia, L., Apostolakidou, M., Ioannidis, O., Simeonidis, S., Mpitsianis, S., Futaba, K., Tam, P. T. H., Ng, S. S. M., Lau, V. N. M., Tse, W. K., Banky, B., Dolhai, E., Horvath, E., Golub, J., Marton, J., Lakatos, L., Susztak, N., Maurya, A. P., Kumawat, H., Saxena, P., Lather, R., Waindeskar, V., Khanduri, A., Goyal, L., Gupta, R., Singh, S., Saksena, A. R., Rayani, B. K., Kasula, J., Raju, K., Shah, M. M., Thammineedi, S. R., Patnaik, S. C., Rathod, D., Poonia, D. R., Vishnoi, J. R., Sharma, N., Byshetty, R., Yadav, R. K., Misra, S., Dhali, A., Dhali, G. K., Biswas, J., Ray, S., Ghose, T., Pipara, A., Singh, H. M., Roy, M. K., Desai, N., Thambudorai, R., Ishwarappagol, V., Chaturvedi, A., Verma, D., Akhtar, N., Gupta, S., Rajan, S., Tiwari, T., Kumar, V., Mahajan, A., Jain, D., Liddle, D., Jyoti, J., Haque, P. D., Jain, R., Veetil, S. K., Prem, W., Lakshminarayana, B., Veerabhadrappa, B., Poojary, P. H., Bhat, R. R. K., Mathew, S., Gupta, L., Bains, L. H., Bains, L., Kumar, M., Singh, N., Lal, P., Sharma, A., Kumar, A., Garg, L., Aggarwal, M., Jakhar, R., Bose, B., Huda, F., Thakur, N., Dhar, P., Seenivasagam, K., Prakash, S., Chaudhari, A., Shukla, A., Mahakalkar, C., Saxena, G., Mahuli, K., Kaple, M., Kshirsagar, S., Mehraj, A., Parray, F., Aziz, G., Chowdri, N., Wani, R. F., Gurcoo, S., Shah, Z., Polamreddy, B. M., Madhavan, S., Subbarayan, S., Vino, S., Aravindan, U., George, G., Harikumar, C. K., Yadev, I. P., Chisthi, M., Revathy, P. S., Sreekumar, R. C., Vijayan, V., Theodore, B., Victor, C., Jesudason, M. R., Arulappan, N., Philip, R., Mittal, R., Durai, S., Creavin, B., Cullinane, C., Davis, C., Flynn, C., Liam, D., Cooke, F., Earley, H., Mccullough, P., Neary, P., Hamilton, V., Trani, A. D., Conversano, I., Cianci, P., Petta, R., Picciariello, A., Altomare, D. F., Martines, G., Grasso, S., Moffa, S., Papagni, V., Zanoni, A., Belvedere, A., Romano, A., Croce, G. D., Tanzanu, M., Rottoli, M., Cardelli, S., Lauro, A., Sartarelli, L., Binetti, M., Cervellera, M., Tonini, V., Sanna, B., Pusceddu, E., Runfola, M., Manunza, R., Pisanu, A., Cois, A., Frongia, F., Esposito, G., Podda, M., Mura, P., Cutelle, C., Ammerata, G., Sena, G., Pignataro, M., Scozzafava, M., Mazza, M., Bruni, A., Curro, G., Hila, J., Ammendola, M., Curcio, S., Signorelli, V., Marano, A., Sasia, D., Borghi, F., Giuffrida, M. C., Bonardello, M., Palmisano, S., Testa, V., Porta, A., Scaltrini, F., Iacob, G., Gaspa, I., Guatteri, L., Coladonato, M., Zapparoli, A., Pesce, A., Feo, C. V., Pindozzi, F., Bigoni, I., Torchiaro, M., Fabbri, N., Cianchi, F., Staderini, F., Elena, F., Coratti, F., Barbato, G., Fortuna, L., Romagnoli, S., Bergamini, C., Villa, G., Cecchini, I., Martellucci, J., Izzo, M., Trafeli, M., Scheiterle, M., Manoocheehri, F., Cagnazzo, F., Spampinato, M. G., Adam, N., Depalma, N., D'Ugo, S., Garritano, S., Mazzeo, C., Cucinotta, E., Melita, F., Viscosi, F., Fleres, F., Biondo, S. A., Tripodi, V. F., Spinelli, A., Foppa, C., Greco, M., Sacchi, M., Carvello, M., Deac, V., Laurenti, V., Frontali, A., Zappone, A., Cammarata, F., Colombo, F., Ferrario, L., Curra, M. C., Danelli, P., Vignali, A., Umberto, C., Mastriale, F., Riccardo, R., Turi, S., Elmore, U., Galimberti, A., Ceretti, A. P., Vespo, D., Opocher, E., Longhi, M., Mariani, N. M., Flandoli, C., Ciulli, C., Vaira, G., Ripamonti, L., Cigagna, L., Oldani, M., Tamini, N., Palumbo, A., Castaldi, A., Antropoli, C., Rupealta, N., Palmiero, N., Donatiello, V., Novi, A., Cappiello, A., Bianco, F., Luca, M. D., Incollingo, P., Esposito, R., Gili, S., Aprea, G., Simone, G. D., Palomba, G., Capuano, M., Basile, R., Tropeano, F. P., Luglio, G., Pagano, G., Palma, G. D. D., Cricri, M., Milone, M., Manigrasso, M. E., Anoldo, P., D'Angelo, S., Marzella, A., Scotto, B., Cuneo, D., Ascari, F., Giulino, G., Varoli, M., Laquatra, N., Fortunato, C., Marino, F., Perrone, F., Pace, M., Convertini, O., Boccia, G., Raiano, G., Nuzzo, M. M. D., Calabria, M., Peltrini, R., Castiglioni, S., Bracale, U., Cervone, C., Rega, D., Caliendo, D., Benetti, E., Delrio, P., Guarino, R., Franciscis, S. D., Coppolino, F., Romano, F. M., Selvaggi, F., Pellino, G., Sciaudone, G., Selvaggi, L., Stefano, M. D., Resendiz, A., Carosso, F., Degiuli, M., Salusso, P., Reddavid, R., Benetti, S., Callari, C., Miceli, D. D., Pardo, D., Sabatino, G., Licari, L., Lirosi, M. C., Sorce, V., Peri, A., Mori, A., Pugliese, L., Filardo, M., Nuccio, P., Dominioni, T., Giuseppina, F., Angelo, F., Raffaele, G., Michele, M., Roberto, P., Mondini, A., Muratore, A., Valentino, C., Calabro, M., Danna, R., Cremonini, C., Sbarbaro, C., Tartaglia, D., Coccolini, F., Chiarugi, M., Musetti, S., Pagani, S., Neri, C. M., Leoni, C., Rossi, E., Randisi, E., Puccini, M., Buccianti, P., Balestri, R., Vasale, A. O., Crescentini, G., Ranieri, G., Sinibaldi, G. I., Biondi, Alberto, Sanesi, A. P., Vacca, C., Lorenzon, Laura, Sollazzi, Liliana, Persiani, Roberto, Pezzuto, Roberto, Ferroni, A. F., Stipa, F., Volturo, L., Moretti, M., Tierno, S. M., Marina, S., Mingoli, A., Fiori, E., Pugliese, F., Brachini, G., Carta, G., Sapienza, P., Lapolla, P., Mazzotta, E., Carannante, F., Capolupo, G. T., Masciana, G., Sica, I., Caricato, M., Antonelli, S., Fiume, D., Spoletini, D., Lisi, G., Carlini, M., Menduni, V., Arturi, A., Proietto, B., Lucia, C. D., Baldi, C., Passantino, D. G., Romeo, G., Paola, M. D., Sensi, B., Sica, G., Siragusa, L., Dauri, M., Franceschill, M., Campanelli, M., Bellato, V., Porcu, A., Garau, A. G. G., Masala, M. L., Oggianu, S., Tedde, T., Perra, T., Pazzola, V., Venezia, D. F., Roviello, F., Giacomini, G., Carbone, L., Marano, L., Verre, L., Marano, M., Ciccarese, A. A., Bagnardi, F., Shahu, J., Siciliano, W., Iacomino, A., Armellin, C., Marson, F., Zanus, G., Santoro, G. A., Paoli, M. D., Grossi, U., Sekimoto, M., Kobayashi, T., Horiguchi, A., Koike, D., Yonekura, H., Kato, H., Yoshino, K., Arakawa, S., Asano, Y., Alawneh, F., Rajab, I., Ramadan, M., Masri, M. A., Qaisi, M. A., Alsamneh, M., Mubaidin, O., Al-Jarrah, A., Ababneh, H., Khdair, K., Tawarh, T., Sabri, W., Arida, Z. A., Dzhumabekov, B., Klyshbayeva, D., Fakhradiyev, I., Ispbayeva, K., Nadyrov, M., Tanabayeva, S., Saliev, T., Jumanov, A., Aitbaeva, A., Arynov, A., Kulimbet, M., Maulenov, N., Dushimova, Z., Park, E. J., Kim, H., Kang, J., Baik, S. H., Song, Y., Kwak, H. D., Kim, J., Son, J. H., Chung, J. S., Lee, H., Baek, J. -H., Nam, K. H., Lee, W. -S., Jeon, Y., Kim, C. W., Park, S. -E., Lee, S. -H., Son, G. M., Ahn, H. M., Lee, I. Y., Kim, T. K., Pcolkins, A., Sivins, A., Lobovs, D., Ancans, G., Kreice, I., Budnikova, I., Jelovskis, I., Emhareb, A., Abaidalla, A., Hammed, A., Khairallah, M., Jibreel, S. S., Mohmmad, W. A. S., Hasan, W., Venskutonis, D., Daugela, E., Dainius, E., Juocas, J., Kutkevicius, J., Vaitkute, K., Bradulskis, S., Macas, A., Pauzas, H., Jokubauskas, M., Lizdenis, P., Budrikiene, R., Saladzinskas, Z., Dulskas, A., Volkoviene, G., Makauskiene, J., Kuliavas, J., Bernotaite, V., Danys, D., Kontrimaviciute, E., Poskus, E., Kryzauskas, M., Jakubauskas, M., Poskus, T., Jotautas, V., Zakaria, A. D., Kai, M. W. P., Zainy, R. H. M., Tan, S. S., Zain, W. Z. W., Zakaria, Z., Yusoff, Z. M., Raduan, F., Sagap, I., Razali, N. Y. F., Rahman, N. A., Kanthan, S. B. C., Nie, Y. C., Azman, Z. A. M., Ang, C. W., Tang, C. Y., Poh, K. S., Ng, K., Hashim, N. M., Xavier, R., Khong, T. L., Amir, A. S., Ali, C. S. C., Yew, C. K., Henry, F., Muniandy, J., Baharom, S., Eng, S. C. R., Hu, F. S. -M., Amin-Tai, H., Jabar, M. F., Satar, M. H. S. A., Fathi, N. Q., Rao, P. S., Podesta, A. M. C., Cini, C., Psaila, J., Debono, M., Sammut, M., Spiteri, N., Andrejevic, P., Muro, A. G., Leon, B. P., Perez, J. A. V., Quinonez, J. R. A., Vera, M. T. R., Gutierrez, V. M. M., Bobadilla, B. J., Martinez, C. M., De Leon Rendon, J. L., Hererro, J. A. V., Cuichan, M. V. Y., Baez, N. F., Prevost, P. G., Hoyos-Torres, A., Ruiz-Munoz, E. A., Alvarez-Bautista, F. E., Ortiz-Mendez, G., Zamudio-Bautista, J. L., Salgado-Nesme, N., Vergara-Fernandez, O., Sanchez-Valdivieso, E., Martinez, G., Navarrete-Aleman, J., Perez-Arellano, J., Maldonado-Barron, R., Hernandez-Krauss, R., Ousadden, A., Benjelloun, E. B., Bzikha, I., Ibnmajdoub, K., Mazaz, K., Marghich, O., Touzani, S., Benkabbou, A., Souadka, A., Ahmadi, B. E., Zaari, F., Laamri, I., Majbar, M. A., Mohsine, R., Van Berlo, C., Seuren, D., Gillissen, F., Aarts, F., Konsten, J., Van Heinsbergen, M., Schlooz, S., Naiqiso, A., Merrie, A., Varghese, C., Pugh, F., Bissett, I., Wilson, K., Mitchell, S., Dawson, C., Hill, C., Wright, D., Hubley, S., Lin, A., Jones, D., Siggins, L., Fagan, P., Wu, S., Ekwesianya, A., Nwoye, C., Agara, D., Ejiofor, G., Sundaynweke, N., Kwentoh, N., Ewah, R., Aremu, A., Ballah, A., Ningi, A., Ohia, E., Mienda, I., Aliyu, M., Oloko, N., Okunlola, A., Abiyere, H., Bolanle, O. E., Babatunde, O., Fatudimu, S., Orewole, T., Mba, E. L., Felix, M. S., Abdulfatah, M., Ibrahim, N., Masoro, U., Fakoya, A., Irabor, D., Anyadike, F., Ulasi, I., Orji, M., Afuwape, O., Ayandipo, O., Adeyeye, A., Aremu, I., Adegboye, K., Gbadegesin, P., Aminu, B., Aghadi, I. K., Makama, J. G., Joshua, S., Kache, S. A., Sheshe, A. A., Bala, A. M., Garzali, I. U., Abdullahi, M. M. M., Muhammad, N., Umar, N. A., Muhammad, S., Okoye, A., Emegoakor, C., Nwosu, C., Egwuonwu, O. A., Ekwunife, O., Amadigwe, R., Ojiakor, S., Akere, A., Okereke, C., Olaleye, O., Ige, O., Olubayo, O., Olatiilu, T., Idris, M., Shehu, A., Oluyori, D., Nwabuoku, E., Ukwubile, L., Bashir, M., Daniyan, M., Rauf, H., Ali, M., Zakaria, M., Hameed, M., Amanullah, N., Chawla, T., Waqar, U., Jamal, A., Butt, A., Kerawala, A., Samson, S., Dodhy, A. A., Gill, A. J., Malik, A., Ali, D., Mohsin, H., Afzal, M. F., Batool, S., Suleman, A., Khalid, J., Zafar, M., Dilawar, M., Janjua, M. H., Sarwar, M. Z., Naqi, S. A., Akbar, A., Afzal, A., Anwar, J., Gondal, K. M., Shaukat, M., Waheed, M., Sohail, M., Mukhtiar, N., Ammar, A. S., Hussain, A., Khan, A. N., Sarwar, A., Khan, I., Khattak, S., Oqaili, B., Saada, B., Zatari, D., Jubran, F., Hamdan, F., Emar, M., Alawi, R., Jacome, G., Insturain, I., Arauz, J., Hurtado, M., Beron, R. I., Castano, R., Cao, V. H. B., Kwiatkowski, A., Dobkowski, G., Bartosiak, K., Waledziak, M., Mozanski, M., Zadrozna, M., Kowalewski, P., Fiedziuk, A., Watroba, A., Los, A., Sitarska, M., Rzaca, M., Zawadzki, M., Czarnecki, R., Tavares, C., Santos, F., Borges, F., Real, J. C., Lima, M. J., Carlos, S., Pereira, V., Pacheco, A., Gomes, G., Pimenta, J., Elisiario, L., Jervis, M., Goncalves, V., Pedro, V., Jordao, D., Neves, F. R., Conceicao, L., Angelo, M. D., Marques, P., Saraiva, R. P., Caroco, T. V., Windels, A., Machado, A., Ribeiro, C., Velez, C., Oliveira, J., Melo, M. R., Lima, R., Pires, A., Lareiro, C., Martins, R., Revez, T., Martins, A., Cardoso, D., Alegre, I., Estevao, P., Andrade, D., Gomes, D. C., Duarte, M. J., Custodio, P., Nemesio, R. A., Rodrigues, S., Correia, A., Domingos, H., Herrando, I., Azevedo, J., Fernandez, L., Azevedo, P., Vieira, P., Torre, A., Amado, A., Paiva, M., Saraiva, R., Costa, S., Mendes, T., Queiros, T., Silva, A., Faustino, A., Freitas, A., Mendes, J., Amaral, L., Quintanilha, R., Coelho, A. M., Ribeiro, A., Pinto, C., Ribeiro, N., Reis, R., Fernandes, V., Sanches, A., Amorim, E., Miguel, I., Rachadell, J., Sanches, M., Oliveira, S., Baptista, V., Roxo, A., Devesa, H., Teslyak, O., Barradas, R., Marques, S., Martins, S., Pepino, S., Deus, A. C., Ferreira, A., Marinho, D., Sousa, D., Martins, M. J., Matias, N., Pinto, A., Correia, D., Amado, F., Cordeiro, L., Morales, M., Lamas, M., Marcal, S., Rodrigues, A. I., Santos, A., Marcal, A., Oliveira, A., Gomes, C., Ferreira, C., Marques, R., Chitul, A., Alexandrescu, C., Bezede, C., Cristian, D., Mandi, D., Grama, F., Ungureanu, R., Stoica, B., Diaconescu, C., Ciubotaru, C., Tanase, I., Grintescu, I., Negoi, I., Negoita, V. M., Calin, C., Simeanu, C., Ciotarla, D. C., Caltea, M., Mirica, R. M., Luca, A., Pasca, A., Vlad, C., Bonci, E. -A., Stefanescu, I., Achimas-Cadariu, P. A., Gata, V. A., Capusan, A., Petrisor, C., Dindelegan, G., Seicean, R., Scurtu, R., Bintintan, V., Fagarasan, V., Ionescu, C., Crisan, D., Zanc, L., Ene-Cocis, M. -V., Muresan, M. -S., Mihalcea, S. M., Dudric, V., Musina, A. -M., Ristescu, A. -I., Roata, C. -E., Moglan, M., Dimofte, M. -G., Lunca, S., Iacob, S., Dychko, A., Litvin, A., Kapustina, A., Provozina, A., Anokhin, E., Zabiyaka, M., Shin, A., Djumabayev, K., Kuznetsova, M., Gordeyev, S., Kochkina, S., Mamedli, Z., Markaryan, D., Galliamov, E., Semina, E., Agapov, M., Malahov, P., Garmanova, T., Kakotkin, V., Zaycev, A., Sumbaev, A., Bedzhanyan, A., Orman, E., Petrenko, K., Bredikhin, M., Frolova, Y., Tulina, I., Bashilkina, O., Tsarkov, P., Rodimov, S., Stamov, V., Balaban, V., Alexnder, A., Yanishev, A., Rogozhev, D., Yakunina, N., Chubukova, N., Nugmanov, R., Karachun, A., Petrov, A., Domanskiy, A., Panaiotti, L., Smolina, M., Sapronova, T., Pelipas, Y., Zagaynov, E., Khrykov, G., Davidovskaja, L., Burlov, N., Mankevich, N., Tverdohlebova, T., Bogatikov, A., Lodygin, A. V., Krasnoselsky, C., Vasiukova, E. -S., Kopteyev, N. R., Ovchinnikov, T., Kashchenko, V. A., Novikova, A., Terentyeva, E., Kuleshov, O., Pavlov, R., Koshel, A., Kostromitsky, D., Drozdov, E., Klokov, S., Camacho, A., Khan, F. N., Bandar, M. A., Shamim, R., Chowdhury, S., Kovacevic, B., Krdzic, I., Zdravkovic, M., Kenic, M., Milentijevic, M., Petkovic, N., Radulovic, R., Ngu, J., Teo, N. Z., Singh, P. A., Ong, S. Y., Li, S., Siew, B., Chee, C., Koh, J. J. M., Lee, K. Y., Tan, K. K., Wong, S. C., Loh, W., Pujol, A. F., Rubio, J. C., Farres, L. P., Vendrell, L. L., Del Olmo, M. I. U., Pedregosa, A. B., Galmes, C., Luckute, D., Casanova, D., Artigot, M., Guedes, X., Olivella, Y., Sarda, M. S., Toscano, M. J., Damieta, M. P., Pera, M., Goncalvez, S. A., Galvez, S. T., Ruiz, S. S., Basany, E., Marinello, F., Villarino-Villa, L., Heras, M. V. -L., Martin-Sanchez, R., Mata, R. M., Blanco-Colino, R., Otero, A., Lacy, A. M. D., Sanahuja, J. M., Bravo, R., Ferraz, T., Gonzabay, V., Gonzalez, F., Menendez, P., Del Castillo, V. C. G., Lopez-Pelaez, V. M., Silva, A. S., Lillo-Garcia, C., Tauler, E. M., Sanchez-Guillen, L., Manresa, M. C. E., Perez, S. L., Llopis, S. Q., Rubio, A. V., Castillo, E. R., Miramon, F. J. J., Rodriguez, J. L. R., Rizo-Lamberti, L. A., Garrido, P. G., Carneros, V. J., Alfonso, B. A., Sierra, B. G., Amador, C. G., Gomendio, M. D. P., Palomino, M. V. R., De La Plaza Llamas, R., Cafranga, E. G., Ramos, J. L. E., Estudillo, M. C., Perez, R. E., Pernas, R. M., Fernandez, S. D. L., Bautista, W. M. S., Llamazares, A. L., Valbuena, A. L., Moran, L. A., Alvarez, L. J., Raposo, L. G., Ceron, S. F., Gonzalez, T. E., Calvo, A. C., Valcarcel, C. R., Pena, J. P., Gomez, L. M. J., Diez, M. C., Lindenbaum, P. D., Mata, S. K., Ruiz-De-La-Hermosa, A., Abad-Motos, A., Toribio-Combarro, B., Ripolles-Melchor, J., Fuenmayor-Valera, M. L., Ortega-Domene, P., Loscos, A., Pueblo, C. S. D., Dziakova, J., Muguerza, J. M., Carlin, P. S., Anula, R., Mouvet, Y., Forero-Torres, A., Andres, B. D. S., Marcos, C. M., Rubio, I., Pascual, I., Yague, J., Alcolea, N. G., Alonso, A., Dieguez, B., Ibanez, I., Perez, J. L., Losada, M., Garcia-Conde, M. G., Hernandez, M., Blazquez-Martin, A., Vera-Mansilla, C., Mendoza-Moreno, F., Hernandez-Salvan, J., Diez-Alonso, M., Hernandez-Juara, P., Barrena-Blazquez, S., Minaya-Bravo, A. M., Galvan-Perez, A., Miguel-Mendez, C. S., Gonzalez-Gonzalez, E., Alvarez-Diez, M., Garcia-Urena, M. A., Llorente-Moreno, M., Ruiz-Lozano, C., Colas-Ruiz, E., Perez-Calvo, J., Gomila-Sanso, J. A., Alvarez-Llano, L., Serrano-Fuentes, S. C., Soto-Montesinos, C., Dedeu-Bastardas, I., Perez-Reche, I., Labro-Ciurans, M., Pardo-Lopez, S., Perez, E. G., Fernandez, I. O., Canals, L. O., Espino, P. C., Ruano, P. G., Ricardo, V., Ros, E. P., Manuel, E. M., Buleje, J. A. B., Prats, M. M. C., Banos, P. A. P., Gonzalez, P. M., Celdran, R. G., Pellicer-Franco, E. M., Valero-Navarro, G., Vicente-Villena, J. P., Martinez-Mercader, M. M., Baeza-Murcia, M., Mengual-Ballester, M., Soria-Aledo, V., Fernandez-Martinez, D., Varela-Rodriguez, L., Garcia-Florez, L. J., Fernandez-Hevia, M., Gonzalez-Diaz, M. J., Fernandez-Arias, S., Puertas, C. P., De San Pio Carvajal, E., Cebolla, E. S., Brainsa, E., Bayo, J. M. M., Castro, M. C., Blanco, R. R., Gutierrez, E., Pinto, F. L., Alegre, J. M., Flores, N., Osullivan, S. N., Fernandez, B. F., Alonso, J. E., Conde, J. G. A., Ropero, N. M., Bayon, R. A., Dominguez, S. H., Ramirez, S., Pablos, A. M. D., Perez-Sanchez, A., Cano-Matias, A., Del-Rio-Lafuente, F. -J., Caballero-Delgado, J., Hernandez, J. V., Gomez-Rosado, J. -C., Martinez, C., Cholewa, H., Sancho-Muriel, J., Alberola, M. J., Navasquillo, M., Primo, V., Moreno, V., Espi-Macias, A., Moro-Valdezate, D., Carrascosa-Morales, I., Martin-Arevalo, J., Soro-Domingo, M., Garcia-Botello, S., Pla-Marti, V., Abellan, A. M., Perez, C. M., Cortes, G. F. V., Blasco, L. F., Chornet, M. R., Martin, R. S., Diego, A. 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F., Satar, M. H. S. A., Fathi, N. Q., Rao, P. S., Podesta, A. M. C., Cini, C., Psaila, J., Debono, M., Sammut, M., Spiteri, N., Andrejevic, P., Muro, A. G., Leon, B. P., Perez, J. A. V., Quinonez, J. R. A., Vera, M. T. R., Gutierrez, V. M. M., Bobadilla, B. J., Martinez, C. M., De Leon Rendon, J. L., Hererro, J. A. V., Cuichan, M. V. Y., Baez, N. F., Prevost, P. G., Hoyos-Torres, A., Ruiz-Munoz, E. A., Alvarez-Bautista, F. E., Ortiz-Mendez, G., Zamudio-Bautista, J. L., Salgado-Nesme, N., Vergara-Fernandez, O., Sanchez-Valdivieso, E., Martinez, G., Navarrete-Aleman, J., Perez-Arellano, J., Maldonado-Barron, R., Hernandez-Krauss, R., Ousadden, A., Benjelloun, E. B., Bzikha, I., Ibnmajdoub, K., Mazaz, K., Marghich, O., Touzani, S., Benkabbou, A., Souadka, A., Ahmadi, B. E., Zaari, F., Laamri, I., Majbar, M. A., Mohsine, R., Van Berlo, C., Seuren, D., Gillissen, F., Aarts, F., Konsten, J., Van Heinsbergen, M., Schlooz, S., Naiqiso, A., Merrie, A., Varghese, C., Pugh, F., Bissett, I., Wilson, K., Mitchell, S., Dawson, C., Hill, C., Wright, D., Hubley, S., Lin, A., Jones, D., Siggins, L., Fagan, P., Wu, S., Ekwesianya, A., Nwoye, C., Agara, D., Ejiofor, G., Sundaynweke, N., Kwentoh, N., Ewah, R., Aremu, A., Ballah, A., Ningi, A., Ohia, E., Mienda, I., Aliyu, M., Oloko, N., Okunlola, A., Abiyere, H., Bolanle, O. E., Babatunde, O., Fatudimu, S., Orewole, T., Mba, E. L., Felix, M. S., Abdulfatah, M., Ibrahim, N., Masoro, U., Fakoya, A., Irabor, D., Anyadike, F., Ulasi, I., Orji, M., Afuwape, O., Ayandipo, O., Adeyeye, A., Aremu, I., Adegboye, K., Gbadegesin, P., Aminu, B., Aghadi, I. K., Makama, J. G., Joshua, S., Kache, S. A., Sheshe, A. A., Bala, A. M., Garzali, I. U., Abdullahi, M. M. M., Muhammad, N., Umar, N. A., Muhammad, S., Okoye, A., Emegoakor, C., Nwosu, C., Egwuonwu, O. A., Ekwunife, O., Amadigwe, R., Ojiakor, S., Akere, A., Okereke, C., Olaleye, O., Ige, O., Olubayo, O., Olatiilu, T., Idris, M., Shehu, A., Oluyori, D., Nwabuoku, E., Ukwubile, L., Bashir, M., Daniyan, M., Rauf, H., Ali, M., Zakaria, M., Hameed, M., Amanullah, N., Chawla, T., Waqar, U., Jamal, A., Butt, A., Kerawala, A., Samson, S., Dodhy, A. A., Gill, A. J., Malik, A., Ali, D., Mohsin, H., Afzal, M. F., Batool, S., Suleman, A., Khalid, J., Zafar, M., Dilawar, M., Janjua, M. H., Sarwar, M. Z., Naqi, S. A., Akbar, A., Afzal, A., Anwar, J., Gondal, K. M., Shaukat, M., Waheed, M., Sohail, M., Mukhtiar, N., Ammar, A. S., Hussain, A., Khan, A. N., Sarwar, A., Khan, I., Khattak, S., Oqaili, B., Saada, B., Zatari, D., Jubran, F., Hamdan, F., Emar, M., Alawi, R., Jacome, G., Insturain, I., Arauz, J., Hurtado, M., Beron, R. I., Castano, R., Cao, V. H. B., Kwiatkowski, A., Dobkowski, G., Bartosiak, K., Waledziak, M., Mozanski, M., Zadrozna, M., Kowalewski, P., Fiedziuk, A., Watroba, A., Los, A., Sitarska, M., Rzaca, M., Zawadzki, M., Czarnecki, R., Tavares, C., Santos, F., Borges, F., Real, J. C., Lima, M. J., Carlos, S., Pereira, V., Pacheco, A., Gomes, G., Pimenta, J., Elisiario, L., Jervis, M., Goncalves, V., Pedro, V., Jordao, D., Neves, F. R., Conceicao, L., Angelo, M. D., Marques, P., Saraiva, R. P., Caroco, T. V., Windels, A., Machado, A., Ribeiro, C., Velez, C., Oliveira, J., Melo, M. R., Lima, R., Pires, A., Lareiro, C., Martins, R., Revez, T., Martins, A., Cardoso, D., Alegre, I., Estevao, P., Andrade, D., Gomes, D. C., Duarte, M. J., Custodio, P., Nemesio, R. A., Rodrigues, S., Correia, A., Domingos, H., Herrando, I., Azevedo, J., Fernandez, L., Azevedo, P., Vieira, P., Torre, A., Amado, A., Paiva, M., Saraiva, R., Costa, S., Mendes, T., Queiros, T., Silva, A., Faustino, A., Freitas, A., Mendes, J., Amaral, L., Quintanilha, R., Coelho, A. M., Ribeiro, A., Pinto, C., Ribeiro, N., Reis, R., Fernandes, V., Sanches, A., Amorim, E., Miguel, I., Rachadell, J., Sanches, M., Oliveira, S., Baptista, V., Roxo, A., Devesa, H., Teslyak, O., Barradas, R., Marques, S., Martins, S., Pepino, S., Deus, A. C., Ferreira, A., Marinho, D., Sousa, D., Martins, M. J., Matias, N., Pinto, A., Correia, D., Amado, F., Cordeiro, L., Morales, M., Lamas, M., Marcal, S., Rodrigues, A. I., Santos, A., Marcal, A., Oliveira, A., Gomes, C., Ferreira, C., Marques, R., Chitul, A., Alexandrescu, C., Bezede, C., Cristian, D., Mandi, D., Grama, F., Ungureanu, R., Stoica, B., Diaconescu, C., Ciubotaru, C., Tanase, I., Grintescu, I., Negoi, I., Negoita, V. M., Calin, C., Simeanu, C., Ciotarla, D. C., Caltea, M., Mirica, R. M., Luca, A., Pasca, A., Vlad, C., Bonci, E. -A., Stefanescu, I., Achimas-Cadariu, P. A., Gata, V. A., Capusan, A., Petrisor, C., Dindelegan, G., Seicean, R., Scurtu, R., Bintintan, V., Fagarasan, V., Ionescu, C., Crisan, D., Zanc, L., Ene-Cocis, M. -V., Muresan, M. -S., Mihalcea, S. M., Dudric, V., Musina, A. -M., Ristescu, A. -I., Roata, C. -E., Moglan, M., Dimofte, M. -G., Lunca, S., Iacob, S., Dychko, A., Litvin, A., Kapustina, A., Provozina, A., Anokhin, E., Zabiyaka, M., Shin, A., Djumabayev, K., Kuznetsova, M., Gordeyev, S., Kochkina, S., Mamedli, Z., Markaryan, D., Galliamov, E., Semina, E., Agapov, M., Malahov, P., Garmanova, T., Kakotkin, V., Zaycev, A., Sumbaev, A., Bedzhanyan, A., Orman, E., Petrenko, K., Bredikhin, M., Frolova, Y., Tulina, I., Bashilkina, O., Tsarkov, P., Rodimov, S., Stamov, V., Balaban, V., Alexnder, A., Yanishev, A., Rogozhev, D., Yakunina, N., Chubukova, N., Nugmanov, R., Karachun, A., Petrov, A., Domanskiy, A., Panaiotti, L., Smolina, M., Sapronova, T., Pelipas, Y., Zagaynov, E., Khrykov, G., Davidovskaja, L., Burlov, N., Mankevich, N., Tverdohlebova, T., Bogatikov, A., Lodygin, A. V., Krasnoselsky, C., Vasiukova, E. -S., Kopteyev, N. R., Ovchinnikov, T., Kashchenko, V. A., Novikova, A., Terentyeva, E., Kuleshov, O., Pavlov, R., Koshel, A., Kostromitsky, D., Drozdov, E., Klokov, S., Camacho, A., Khan, F. N., Bandar, M. A., Shamim, R., Chowdhury, S., Kovacevic, B., Krdzic, I., Zdravkovic, M., Kenic, M., Milentijevic, M., Petkovic, N., Radulovic, R., Ngu, J., Teo, N. Z., Singh, P. A., Ong, S. Y., Li, S., Siew, B., Chee, C., Koh, J. J. M., Lee, K. Y., Tan, K. K., Wong, S. C., Loh, W., Pujol, A. F., Rubio, J. C., Farres, L. P., Vendrell, L. L., Del Olmo, M. I. U., Pedregosa, A. B., Galmes, C., Luckute, D., Casanova, D., Artigot, M., Guedes, X., Olivella, Y., Sarda, M. S., Toscano, M. J., Damieta, M. P., Pera, M., Goncalvez, S. A., Galvez, S. T., Ruiz, S. S., Basany, E., Marinello, F., Villarino-Villa, L., Heras, M. V. -L., Martin-Sanchez, R., Mata, R. M., Blanco-Colino, R., Otero, A., Lacy, A. M. D., Sanahuja, J. M., Bravo, R., Ferraz, T., Gonzabay, V., Gonzalez, F., Menendez, P., Del Castillo, V. C. G., Lopez-Pelaez, V. M., Silva, A. S., Lillo-Garcia, C., Tauler, E. M., Sanchez-Guillen, L., Manresa, M. C. E., Perez, S. L., Llopis, S. Q., Rubio, A. V., Castillo, E. R., Miramon, F. J. J., Rodriguez, J. L. R., Rizo-Lamberti, L. A., Garrido, P. G., Carneros, V. J., Alfonso, B. A., Sierra, B. G., Amador, C. G., Gomendio, M. D. P., Palomino, M. V. R., De La Plaza Llamas, R., Cafranga, E. G., Ramos, J. L. E., Estudillo, M. C., Perez, R. E., Pernas, R. M., Fernandez, S. D. L., Bautista, W. M. S., Llamazares, A. L., Valbuena, A. L., Moran, L. A., Alvarez, L. J., Raposo, L. G., Ceron, S. F., Gonzalez, T. E., Calvo, A. C., Valcarcel, C. R., Pena, J. P., Gomez, L. M. J., Diez, M. C., Lindenbaum, P. D., Mata, S. K., Ruiz-De-La-Hermosa, A., Abad-Motos, A., Toribio-Combarro, B., Ripolles-Melchor, J., Fuenmayor-Valera, M. L., Ortega-Domene, P., Loscos, A., Pueblo, C. S. D., Dziakova, J., Muguerza, J. M., Carlin, P. S., Anula, R., Mouvet, Y., Forero-Torres, A., Andres, B. D. S., Marcos, C. M., Rubio, I., Pascual, I., Yague, J., Alcolea, N. G., Alonso, A., Dieguez, B., Ibanez, I., Perez, J. L., Losada, M., Garcia-Conde, M. G., Hernandez, M., Blazquez-Martin, A., Vera-Mansilla, C., Mendoza-Moreno, F., Hernandez-Salvan, J., Diez-Alonso, M., Hernandez-Juara, P., Barrena-Blazquez, S., Minaya-Bravo, A. M., Galvan-Perez, A., Miguel-Mendez, C. S., Gonzalez-Gonzalez, E., Alvarez-Diez, M., Garcia-Urena, M. A., Llorente-Moreno, M., Ruiz-Lozano, C., Colas-Ruiz, E., Perez-Calvo, J., Gomila-Sanso, J. A., Alvarez-Llano, L., Serrano-Fuentes, S. C., Soto-Montesinos, C., Dedeu-Bastardas, I., Perez-Reche, I., Labro-Ciurans, M., Pardo-Lopez, S., Perez, E. G., Fernandez, I. O., Canals, L. O., Espino, P. C., Ruano, P. G., Ricardo, V., Ros, E. P., Manuel, E. M., Buleje, J. A. B., Prats, M. M. C., Banos, P. A. P., Gonzalez, P. M., Celdran, R. G., Pellicer-Franco, E. M., Valero-Navarro, G., Vicente-Villena, J. P., Martinez-Mercader, M. M., Baeza-Murcia, M., Mengual-Ballester, M., Soria-Aledo, V., Fernandez-Martinez, D., Varela-Rodriguez, L., Garcia-Florez, L. J., Fernandez-Hevia, M., Gonzalez-Diaz, M. J., Fernandez-Arias, S., Puertas, C. P., De San Pio Carvajal, E., Cebolla, E. S., Brainsa, E., Bayo, J. M. M., Castro, M. C., Blanco, R. R., Gutierrez, E., Pinto, F. L., Alegre, J. M., Flores, N., Osullivan, S. N., Fernandez, B. F., Alonso, J. E., Conde, J. G. A., Ropero, N. M., Bayon, R. A., Dominguez, S. H., Ramirez, S., Pablos, A. M. D., Perez-Sanchez, A., Cano-Matias, A., Del-Rio-Lafuente, F. -J., Caballero-Delgado, J., Hernandez, J. V., Gomez-Rosado, J. -C., Martinez, C., Cholewa, H., Sancho-Muriel, J., Alberola, M. J., Navasquillo, M., Primo, V., Moreno, V., Espi-Macias, A., Moro-Valdezate, D., Carrascosa-Morales, I., Martin-Arevalo, J., Soro-Domingo, M., Garcia-Botello, S., Pla-Marti, V., Abellan, A. M., Perez, C. M., Cortes, G. F. V., Blasco, L. F., Chornet, M. R., Martin, R. S., Diego, A. R. -D., Vazquez-Fernandez, A., Pascual, A., Andres-Asenjo, B. D., Heredia, J. B. D., Ruiz-Soriano, M., Rodriguez-Jimenez, R., Iribarren, E. M., Rodriguez, E. V. F., Garcia, M. D. C. C., Garcia-Senorans, M. P., Valderrama, O. C., Rodriguez, P. F., Santos, R. S., Curras, R. P., Vigorita, V., Roche, C. G., Delgado, E., Lafuente, F., Gascon, I., Mallen, M. V. D., Saudi, S., Fraj, V., Wickramasinghe, D., Zoysa, I. D., Samarasekera, N., Wickramarathne, R., Dassanayake, V., Balathayalan, Y., De Silva, D., Perera, M., Pulleperuma, S., Jayasekara, S., Wijenayake, W., Gunetilleke, B., Abeysinghe, N., Chandrasinghe, P., Kumarage, S., Abdalradiy, A. G., Widatalla, A. B. H., Ahmed, A. Y., Mohamed, H. A., Hamid, H. K. S., Ali, M. H., Eldin, S. J., Agger, E., Jutesten, H., Lindgren, J., Lepsenyi, M., Azhar, N., Buchwald, P., Hansdotter, P., Ekepil, A., Linden, A., Brandstrom, G., Smedberg, J., Schiffer, E., Ris, F., Longchamp, G., Meyer, J., Dupret, L., Buchs, N., Galetti, K., Regusci, L., Grischott, M., Malugani, M., Mouhandes, A. E. -F., Danial, A. K., Khayat, M., Sbahi, M. H. E., Marawy, M. K., Abdullah, M. A., Douba, Z., Mansour, A., Niazi, A., Hamza, A., Mohamad, A. H., Awead, M., Mohammad, S., Salloum, S., Jabar, A. A., Zazo, A., Shebli, B., Ayoub, K., Younes, L., Bannoud, M. H., Zazo, R., Saad, A., Hamdan, A., Wakkaf, H., Adra, L., Souliman, M., Anton, M., Hannouf, S., Wang, J. Y., Li, K. L., Cheng, K. I., Ji, S. J., Hsieh, Y. C., Parlak, E. A., Demir, M., Kara, U., Peker, Y. S., Yigit, D., Unal, N., Iflazoglu, N., Yalkin, O., Topal, S., Gulcu, B., Ozturk, E., Gumbelek, G., Terkanlioglu, S., Koklucan, A., Ince, G., Sen, M., Isik, O., Kural, S., Akesen, S., Yilmazlar, T., Sungurtekin, H., Sungurtekin, U., Vural, U., Ozgen, U., Isik, A., Onk, D., Kurnaz, E., Ozker, T. S., Ipek, A., Ferlengez, A., Erturk, C., Tatar, C., Sevik, H., Akay, O., Sensoy, O., Hayirlioglu, M. B., Aktas, S., Ozben, V., Aliyeva, Z., Mutlu, A. U., Gokay, B. V., Saracoglu, C., Aytac, E., Gulmez, M., Isik, M. U., Hacim, A., Akbas, A., Soyhan, F., Turgut, M. A., Demirgan, S., Meric, S., Altinel, Y., Baris, B., Akova, E., Kahraman, E., Kucuk, H. F., Saracoglu, K. T., Kaya, S., Lel, S., Gurbulak, E. K., Caz, E., Kostek, M., Mihmanli, M., Yazici, P., Oba, S., Kirkan, E. F., Ulgur, H. S., Kalin, M., Dinkci, M. D., Ozkan, O. F., Duzgun, O., Ozturk, S., Zengin, A. K., Askar, A., Sanli, A. N., Erginoz, E., Ozcelik, M. F., Ergun, S., Uludag, S. S., Kara, D., Yilmaz, G., Sarici, I. S., Kara, Y., Incesu, A., Arican, C., Atici, S. D., Kaya, T., Gezer, T., Kirmizi, Y., Kamer, E., Aydin, G., Namdaroglu, O., Adakaya, S., Canda, A. E., Ozzeybek, D., Coskun, N., Sokmen, S., Ozkardesler, S., Bisgin, T., Miftari, A., Caliskan, C., Akgun, E., Avseren, G., Deniz, N., Bozbiyik, O., Yoldas, T., Guresin, A., Zayakov, G., Posteki, G., Utkan, N. Z., Tatar, O. C., Akcay, O., Guler, S. A., Mantoglu, B., Demirel, E., Akin, E., Gonullu, E., Altintoprak, F., Palabiyik, O., Bayhan, Z., Ciftci, A. B., Colak, E., Aybar, E., Celik, H. K., Eraslan, H., Yemez, K., Ozbilgin, S. S., Senol, S., Gultekin, F. A., Piskin, O., Guler, O., Karadere, Y., Kakeeto, A., Oguttu, B., Sikakulya, F. K., Lule, H., Rybachuk, A., Shudrak, A., Beznosenko, A., Lisnyy, I., Rozhkova, V., Zvirych, V., Alawlaqi, D., Jamali, F. E., Balooshi, I. A., Albers, M., Ali, N. A., Church, R., Dudas, G., Wells, J., Pavlova, M., Sebastiani, S., Paterson, C., Kaushal, M., Patel, P., Panchal, S., Handa, S., Tezas, S., Zaidi, S. -N., Raj, G., Wright, J., Hallam, S., Karandikar, S., Gates, Z., Marshall, A., Thompson, A., Tennakoon, A., Rao, M., Callan, R., Tufail, S., Rajendran, G., Polisetty, K., Husain, N., Clarke, N., Naranayanasamy, S., Hallett, A., Lorejo, E., Ward, N., Antakia, R., Xanthis, A., Simillis, C., Tweedle, E., Panagiotopoulou, I., Grimes, L., Mounstephen, L., Bocancia, R., Carden, C., Lynch, J., Noveros, M. S., Shaalan, R., Khalil, T., Marshall, W., Hodge, K., Balfour, J., Mcintosh, K., Buijs, L., Potter, M. A., Yule, M., Vaughan-Shaw, P. G., Smith, S., Anderson, T., Mcdermott, F. D., Daniels, I. R., Tapp, J., Smart, N., Rajaretnam, N., Bethune, R., Clark, T., Delimpalta, C., Liao, C., Banham, G., Induruwage, L., Velchuru, V., Lawrence, A., Rahman, A., Bennett, J., Badawi, M., Harshen, R., Bhargava, A., Gorrela, K., Jumah, M., Venn, M., Hanson, M., Arya, S., Atendido, T., Shrestha, A., Cook, E., Rakhimov, I., Collins, J., Alamin, N., Vigneswaran, N., Basnyat, P., Shamardal, A., Chacko, A., Wanshantha, D., Bisheet, G., Ebdewi, H., Abdellatif, M., Adu-Poku, P., Tore, A., Adams, F., Allen, K., Ahmed, K., Kulkarni, N., Chitnis, A., Patel, H., Magsino, J., Sarodaya, V., Minicozzi, A., Dempsy, C., Ahmed, H., Jayasinghe, J. D., Okail, M. H., Thaha, M., Hallworth, S., Parmar, C., Chua, L., Pizanias, M., Samin, R., Young, T., Sagar, J., Yorkmui, L., Cirocchi, N., Ahmed, S., Barreda, S. C., Kudchadkar, S., Baker, A., Jayasankar, B., Balasubramaniam, D., Jackson, J., Abdelsaid, K., Hassan, M., Shetty, S., Coldwell, C., Davies, E., Nader, H., Raistrick, M., Ryska, O., Hawkin, P., Raymond, T., Witjes, C., Steen, K. V. D., Crabtree, N., Boyce, S., Somera, W., Woodward, A., Ryan, K., Kassai, M., Aleem, M., Ghosh, A., Rixson, D., Lewis, E., Lynch, N., Shovelton, C., Zywicka, E., Guest, F., Barton, J., Purnell, R., Bamford, R., Teare, T., Adams, B., Chmielewski, G., Smith, I., Smith, L., Connolly, L., Niblett, R., Singh, A., Halliwell, G., Paraoan, M., Doree, N., Asaad, P., Kilbride, C., Carpenter, H., Wilson, J., Fletcher, J., Vijayagopal, K. A., Abbakar, M., Zaimis, T., Walsh, A., Kubisz-Pudelko, A. A., Nono, J., Pippard, L., Chowdhary, M., Dalton, R., Moussa, T., Dominguez, F., Solla, G., Curbelo, J., Laurini, M., Viola, M., Brito, N., Al-Alnsi, A., Al-Naggar, H., Saryah, L., Al-Shehari, M., Alsayadi, R., Al-Hutheifi, R., Shream, S., Biondi A. (ORCID:0000-0002-2470-7858), Lorenzon L. (ORCID:0000-0001-6736-0383), Sollazzi L. (ORCID:0000-0002-2973-6236), Persiani R. (ORCID:0000-0002-1537-5097), and Pezzuto R.
- Abstract
Background: Anastomotic leak affects 8 per cent of patients after right colectomy with a 10-fold increased risk of postoperative death. The EAGLE study aimed to develop and test whether an international, standardized quality improvement intervention could reduce anastomotic leaks.Methods: The internationally intended protocol, iteratively co-developed by a multistage Delphi process, comprised an online educational module introducing risk stratification, an intraoperative checklist, and harmonized surgical techniques. Clusters (hospital teams) were randomized to one of three arms with varied sequences of intervention/data collection by a derived stepped-wedge batch design (at least 18 hospital teams per batch). Patients were blinded to the study allocation. Low- and middle-income country enrolment was encouraged. The primary outcome (assessed by intention to treat) was anastomotic leak rate, and subgroup analyses by module completion (at least 80 per cent of surgeons, high engagement; less than 50 per cent, low engagement) were preplanned.Results: A total 355 hospital teams registered, with 332 from 64 countries (39.2 per cent low and middle income) included in the final analysis. The online modules were completed by half of the surgeons (2143 of 4411). The primary analysis included 3039 of the 3268 patients recruited (206 patients had no anastomosis and 23 were lost to follow-up), with anastomotic leaks arising before and after the intervention in 10.1 and 9.6 per cent respectively (adjusted OR 0.87, 95 per cent c.i. 0.59 to 1.30; P = 0.498). The proportion of surgeons completing the educational modules was an influence: the leak rate decreased from 12.2 per cent (61 of 500) before intervention to 5.1 per cent (24 of 473) after intervention in high-engagement centres (adjusted OR 0.36, 0.20 to 0.64; P < 0.001), but this was not observed in low-engagement hospitals (8.3 per cent (59 of 714) and 13.8 per cent (61 of 443) respectively; adjusted OR 2.09, 1.31 to 3.31
- Published
- 2024
21. Flow transitions in collisions between vortex-rings and density interfaces
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Yeo, K. W. B., Koh, J. Y., Long, J., and New, T. H.
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- 2020
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22. Editor's note to “3D-printed biomimetic structures for energy and environmental applications” [DeCarbon 3 (2024) 100026]
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Li, Jiaming, Li, Mengli, Koh, J. Justin, Wang, John, and Lyu, Zhiyang
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- 2024
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23. Determinants of the CmoB carboxymethyl transferase utilized for selective tRNA wobble modification
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Babbitt, Patricia, Kim, J, Xiao, H, Koh, J, Wang, Y, Bonanno, JB, Thomas, K, Babbitt, PC, Brown, S, Lee, YS, and Almo, SC
- Abstract
© 2015 The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.Enzyme-mediated modifications at the wobble position of tRNAs are essential for the translation of the genetic code. We report the genetic, biochemical and
- Published
- 2015
24. Amorphous Cellulose Electrolyte for Long Life and Mechanically Robust Aqueous Structural Batteries
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Lim, Gwendolyn J.H., primary, Koh, J. Justin, additional, Chan, Kwok Kiong, additional, Verma, Vivek, additional, Chua, Rodney, additional, Koh, Xue Qi, additional, Kidkhunthod, Pinit, additional, Sutrisnoh, Nur Ayu Afira, additional, and Srinivasan, Madhavi, additional
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- 2024
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25. RWD49 Real-World Evidence From a Federated Data Network to Reduce Uncertainty in the Long-Term Extrapolations of Oncology Treatments
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Dietz, J., primary, Claire, R., additional, Love-Koh, J., additional, Elvidge, J., additional, Newby, D., additional, Burn, E., additional, and Dawoud, D., additional
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- 2023
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26. Fully biodegradable Poly(lactic acid)/Starch blends: A review of toughening strategies
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Koh, J. Justin, Zhang, Xiwen, and He, Chaobin
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- 2018
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27. CD4 T cell count is inversely associated with lumbar spine bone mass in HIV-infected men under the age of 50 years
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Kwak, M. K., Lee, E. J., Park, J. W., Park, S. Y., Kim, B. -J., Kim, T. H., Suh, K., Koh, J. -M., Lee, S. H., and Byun, D. -W.
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- 2019
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28. Pre-discharge prognostic factors of physical function among older adults with hip fracture surgery: a systematic review
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Lim, K. K., Matchar, D. B., Chong, J. L., Yeo, W., Howe, T. S., and Koh, J. S. B.
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- 2019
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29. The effects of cortisol and adrenal androgen on bone mass in Asians with and without subclinical hypercortisolism
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Ahn, S.H., Kim, J. H., Cho, Y. Y., Suh, S., Kim, B.-J., Hong, S., Lee, S.H., Koh, J.-M., and Song, K.-H.
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- 2019
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30. Association of blood n-3 fatty acid with bone mass and bone marrow TRAP-5b in the elderly with and without hip fracture
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Kim, B.-J., Yoo, H. J., Park, S. J., Kwak, M. K., Lee, S. H., Kim, S. J., Hamrick, M. W., Isales, C. M., Ahn, S. H., and Koh, J.-M.
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- 2019
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31. Impact and Cost-effectiveness of Selective Human Papillomavirus Vaccination of Men Who Have Sex With Men
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Lin, Allen, Ong, Koh J., Hobbelen, Peter, King, Eleanor, Mesher, David, Edmunds, W. John, Sonnenberg, Pam, Gilson, Richard, Bains, Irenjeet, Choi, Yoon H., Tanton, Clare, Soldan, Kate, and Jit, Mark
- Published
- 2017
32. Impact of height difference between coronary ostium and location of intracoronary pressure sensor on fractional flow reserve measurements
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Soh, M, primary, Kim, H, additional, Lim, H, additional, and Koh, J, additional
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- 2023
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33. Intensity of dual antiplatelet therapy based on thrombotic and bleeding risks after coronary stenting
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Kim, J S, primary, Jeong, Y H, additional, Ahn, J H, additional, Kang, M G, additional, Koh, J S, additional, Park, Y W, additional, Hwang, S J, additional, Hwang, J Y, additional, Park, Y H, additional, Hwang, K W, additional, Lee, S H, additional, Lee, S Y, additional, Choi, J H, additional, Kim, S H, additional, and Lim, J H, additional
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- 2023
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34. Effect of symptoms recognition in patients with recurrent acute myocardial infarction: from KRAMI-RCC
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Kim, K, primary, Kim, H R, additional, Koh, J S, additional, Kang, M G, additional, Park, J R, additional, and Hwang, J Y, additional
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- 2023
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35. The Early and Late Effects of High-Dose Irradiation on Cardiac Injury in a Rat Model
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Lee, H.I., primary, Chang, J.H., additional, Koh, J., additional, Cha, M.J., additional, and Kim, H.J., additional
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- 2023
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36. OP17.02: Fetal cardiac capillary hemangioma presenting various types of arrhythmias, and its cardiac function assessment
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Shin, M., primary, Koh, J., additional, and Won, H., additional
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- 2023
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37. OP17.08: A step forward in predicting postnatal outcome of double aortic arch with prenatally diagnosed: a right‐to‐left aortic arch diameter ratio and subtype
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Hong, Y., primary, Won, H., additional, Ahn, C., additional, Kwon, J., additional, Kim, S., additional, Koh, J., additional, Lee, M., additional, and Chung, J., additional
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- 2023
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38. OP10.02: Prenatal detection of associated cleft palate in fetuses with cleft lip using Doppler ultrasonography
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Lee, Y., primary, Lee, M., additional, Kim, J., additional, Koh, J., additional, Kim, S., additional, Chung, J., additional, and Won, H., additional
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- 2023
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39. OC17.02: Comparison of clinical usefulness between previously reported z‐scores and new Korean z‐scores for prenatal diagnosis of coarctation of the aorta
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Lee, Y., primary, Lee, M., additional, Choi, E., additional, Koh, J., additional, Kim, S., additional, Chung, J., additional, Won, H., additional, Kim, R., additional, and Seol, H., additional
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- 2023
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40. EP24.23: Comparison of postnatal prognosis in cases with pulmonary atresia with ventricular septal defect according to different pulmonary circulation type
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Lee, Y., primary, Won, H., additional, Lee, J., additional, Min, J., additional, Koh, J., additional, Kim, S., additional, Lee, M., additional, and Chung, J., additional
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- 2023
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41. EP03.04: Prenatal sonographic characteristics of fetal intra‐abdominal extralobal pulmonary sequestration correlated with perinatal outcomes
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Koh, J., primary, Choi, S., additional, Lee, A., additional, Lee, M., additional, and Won, H., additional
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- 2023
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42. The association of cortisol and adrenal androgen with trabecular bone score in patients with adrenal incidentaloma with and without autonomous cortisol secretion
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Kim, B.-J., Kwak, M.K., Ahn, S.H., Kim, J.S., Lee, S.H., and Koh, J.-M.
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- 2018
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43. Synthesis and Structure of Di(1,2,4,6-tetraphenylpyridinium) Octachlorodirhenate(III)
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Balasekaran, S. Mariappan, Koh, J. J., Han, H., Bhowmik, P. K., Noll, B. C., and Poineau, F.
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- 2018
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44. The positive association of total protein intake with femoral neck strength (KNHANES IV)
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Kim, B.-J., Lee, S. H., Isales, C. M., Koh, J.-M., and Hamrick, M. W.
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- 2018
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45. Low incidence of neurological recurrent side effects following COVID-19 reimmunization
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Koh, J S, primary, Cook, A R, additional, and Seet, R C S, additional
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- 2023
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46. D.H. Lawrence and the Great War : destruction and creation in European history
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Koh, J. K.
- Subjects
820.90091 - Abstract
Lawrence believed that the gigantic cataclysm of the Great War was the result of a long historico-cultural process which had shaped the European psyche in profound ways. His belief that Christian idealism could have a cumulative effect on successive generations implies a Lamarckian notion of the 'inheritance of acquired characteristics'. The firm code of behaviour, the discipline and the restraints on the senses and the ego, which Christianity stood for, became steadily internalised and increasingly instinctive through the Christian centuries in Europe. And as the process continued it became more and more difficult to break away from that ethos. Lawrence reflected on the central causes of the Great War in this perspective, concluding that they could be found in the psychological correlation between the over-emphasis of the 'spiritual' inherent in the Christian tradition, and the accompanying denial and repression of the 'sensual' instincts - the deep natural energies of man. Lawrence's imaginative response to the War reflects his genuine horror at what he saw happening around him. He condemned the baseness and repulsiveness of an industrialised and mechanised Europe, its pretensions to civilisation so barbarously exposed by the war. Lawrence however, did not stop at the destruction occasioned by the war: the question he (with many of his contemporaries) felt they had to explore - Women in Love, in particular, wrestles with it - was whether, through this cataclysm, would come a transition to a new world. In his fiction and his essays, Lawrence presents a possible basis for a culturally regenerated society: its foundation would be a kind of social relationship which has its roots in the pre-industrial order. For Lawrence, 'blood-warmth' was what linked human beings; it is an expression of our deepest psychic needs and desires, and as such represents a bond between people with its basis in something shrewder and more perceptive than any conscious choice or decision. The Great War, for Lawrence, was a hugely destructive event - yet looked at in the very long term, in relation to the major phase of human history which was the Christian era - it could be seen as not an end, but as the culmination of the negative part of a major historical cycle, and as the necessarily destructive prelude to and preparation for a new cultural beginning.
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- 1998
47. Prognostic indicators and outcomes of hospitalised COVID-19 patients with neurological disease: An individual patient data meta-analysis
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Singh, B, Lant, S, Cividini, S, Cattrall, J, Goodwin, L, Benjamin, L, Michael, B, Khawaja, A, Matos, A, Alkeridy, W, Pilotto, A, Lahiri, D, Rawlinson, R, Mhlanga, S, Lopez, E, Sargent, B, Somasundaran, A, Tamborska, A, Webb, G, Younas, K, Al Sami, Y, Babu, H, Banks, T, Cavallieri, F, Cohen, M, Davies, E, Dhar, S, Modol, A, Farooq, H, Harte, J, Hey, S, Joseph, A, Karthikappallil, D, Kassahun, D, Lipunga, G, Mason, R, Minton, T, Mond, G, Poxon, J, Rabas, S, Soothill, G, Zedde, M, Yenkoyan, K, Brew, B, Contini, E, Cysique, L, Zhang, X, Maggi, P, van Pesch, V, Lechien, J, Saussez, S, Heyse, A, Brito Ferreira, M, Soares, C, Elicer, I, Eugenin-Von Bernhardi, L, Reyes, W, Yin, R, Azab, M, Abd-Allah, F, Elkady, A, Escalard, S, Corvol, J, Delorme, C, Tattevin, P, Bigaut, K, Lorenz, N, Hornuss, D, Hosp, J, Rieg, S, Wagner, D, Knier, B, Lingor, P, Winkler, A, Sharifi-Razavi, A, Moein, S, Seyed Alinaghi, S, Jamali Moghadam Siahkali, S, Morassi, M, Padovani, A, Giunta, M, Libri, I, Beretta, S, Ravaglia, S, Foschi, M, Calabresi, P, Primiano, G, Servidei, S, Mercuri, N, Liguori, C, Pierantozzi, M, Sarmati, L, Boso, F, Garazzino, S, Mariotto, S, Patrick, K, Costache, O, Pincherle, A, Klok, F, Meza, R, Cabreira, V, Valdoleiros, S, Oliveira, V, Kaimovsky, I, Guekht, A, Koh, J, Diaz, E, Barrios-Lopez, J, Guijarro-Castro, C, Beltran-Corbellini, A, Martinez-Poles, J, Diezma-Martin, A, Morales-Casado, M, Garcia, S, Breville, G, Coen, M, Uginet, M, Bernard-Valnet, R, Pasquier, R, Kaya, Y, Abdelnour, L, Rice, C, Morrison, H, Defres, S, Huda, S, Enright, N, Hassell, J, D'Anna, L, Benger, M, Sztriha, L, Raith, E, Chinthapalli, K, Nortley, R, Paterson, R, Chandratheva, A, Werring, D, Dervisevic, S, Harkness, K, Pinto, A, Jillella, D, Beach, S, Gunasekaran, K, Ferreira Da Silva, I, Nalleballe, K, Santoro, J, Scullen, T, Kahn, L, Kim, C, Thakur, K, Jain, R, Umapathi, T, Nicholson, T, Sejvar, J, Hodel, E, Smith, C, Solomon, T, Singh B., Lant S., Cividini S., Cattrall J. W. S., Goodwin L. C., Benjamin L., Michael B. D., Khawaja A., Matos A. D. M. B., Alkeridy W., Pilotto A., Lahiri D., Rawlinson R., Mhlanga S., Lopez E. C., Sargent B. F., Somasundaran A., Tamborska A., Webb G., Younas K., Al Sami Y., Babu H., Banks T., Cavallieri F., Cohen M., Davies E., Dhar S., Modol A. F., Farooq H., Harte J., Hey S., Joseph A., Karthikappallil D., Kassahun D., Lipunga G., Mason R., Minton T., Mond G., Poxon J., Rabas S., Soothill G., Zedde M., Yenkoyan K., Brew B., Contini E., Cysique L., Zhang X., Maggi P., van Pesch V., Lechien J., Saussez S., Heyse A., Brito Ferreira M. L., Soares C. N., Elicer I., Eugenin-Von Bernhardi L., Reyes W. N., Yin R., Azab M. A., Abd-Allah F., Elkady A., Escalard S., Corvol J. -C., Delorme C., Tattevin P., Bigaut K., Lorenz N., Hornuss D., Hosp J., Rieg S., Wagner D., Knier B., Lingor P., Winkler A. S., Sharifi-Razavi A., Moein S. T., Seyed Alinaghi S. A., Jamali Moghadam Siahkali S., Morassi M., Padovani A., Giunta M., Libri I., Beretta S., Ravaglia S., Foschi M., Calabresi P., Primiano G., Servidei S., Mercuri N. B., Liguori C., Pierantozzi M., Sarmati L., Boso F., Garazzino S., Mariotto S., Patrick K. N., Costache O., Pincherle A., Klok F. A., Meza R., Cabreira V., Valdoleiros S. R., Oliveira V., Kaimovsky I., Guekht A., Koh J., Diaz E. F., Barrios-Lopez J. M., Guijarro-Castro C., Beltran-Corbellini A., Martinez-Poles J., Diezma-Martin A. M., Morales-Casado M. I., Garcia S. G., Breville G., Coen M., Uginet M., Bernard-Valnet R., Pasquier R. D., Kaya Y., Abdelnour L. H., Rice C., Morrison H., Defres S., Huda S., Enright N., Hassell J., D'Anna L., Benger M., Sztriha L., Raith E., Chinthapalli K., Nortley R., Paterson R., Chandratheva A., Werring D. J., Dervisevic S., Harkness K., Pinto A., Jillella D., Beach S., Gunasekaran K., Ferreira Da Silva I. R., Nalleballe K., Santoro J., Scullen T., Kahn L., Kim C. Y., Thakur K. T., Jain R., Umapathi T., Nicholson T. R., Sejvar J. J., Hodel E. M., Smith C. T., Solomon T., Singh, B, Lant, S, Cividini, S, Cattrall, J, Goodwin, L, Benjamin, L, Michael, B, Khawaja, A, Matos, A, Alkeridy, W, Pilotto, A, Lahiri, D, Rawlinson, R, Mhlanga, S, Lopez, E, Sargent, B, Somasundaran, A, Tamborska, A, Webb, G, Younas, K, Al Sami, Y, Babu, H, Banks, T, Cavallieri, F, Cohen, M, Davies, E, Dhar, S, Modol, A, Farooq, H, Harte, J, Hey, S, Joseph, A, Karthikappallil, D, Kassahun, D, Lipunga, G, Mason, R, Minton, T, Mond, G, Poxon, J, Rabas, S, Soothill, G, Zedde, M, Yenkoyan, K, Brew, B, Contini, E, Cysique, L, Zhang, X, Maggi, P, van Pesch, V, Lechien, J, Saussez, S, Heyse, A, Brito Ferreira, M, Soares, C, Elicer, I, Eugenin-Von Bernhardi, L, Reyes, W, Yin, R, Azab, M, Abd-Allah, F, Elkady, A, Escalard, S, Corvol, J, Delorme, C, Tattevin, P, Bigaut, K, Lorenz, N, Hornuss, D, Hosp, J, Rieg, S, Wagner, D, Knier, B, Lingor, P, Winkler, A, Sharifi-Razavi, A, Moein, S, Seyed Alinaghi, S, Jamali Moghadam Siahkali, S, Morassi, M, Padovani, A, Giunta, M, Libri, I, Beretta, S, Ravaglia, S, Foschi, M, Calabresi, P, Primiano, G, Servidei, S, Mercuri, N, Liguori, C, Pierantozzi, M, Sarmati, L, Boso, F, Garazzino, S, Mariotto, S, Patrick, K, Costache, O, Pincherle, A, Klok, F, Meza, R, Cabreira, V, Valdoleiros, S, Oliveira, V, Kaimovsky, I, Guekht, A, Koh, J, Diaz, E, Barrios-Lopez, J, Guijarro-Castro, C, Beltran-Corbellini, A, Martinez-Poles, J, Diezma-Martin, A, Morales-Casado, M, Garcia, S, Breville, G, Coen, M, Uginet, M, Bernard-Valnet, R, Pasquier, R, Kaya, Y, Abdelnour, L, Rice, C, Morrison, H, Defres, S, Huda, S, Enright, N, Hassell, J, D'Anna, L, Benger, M, Sztriha, L, Raith, E, Chinthapalli, K, Nortley, R, Paterson, R, Chandratheva, A, Werring, D, Dervisevic, S, Harkness, K, Pinto, A, Jillella, D, Beach, S, Gunasekaran, K, Ferreira Da Silva, I, Nalleballe, K, Santoro, J, Scullen, T, Kahn, L, Kim, C, Thakur, K, Jain, R, Umapathi, T, Nicholson, T, Sejvar, J, Hodel, E, Smith, C, Solomon, T, Singh B., Lant S., Cividini S., Cattrall J. W. S., Goodwin L. C., Benjamin L., Michael B. D., Khawaja A., Matos A. D. M. B., Alkeridy W., Pilotto A., Lahiri D., Rawlinson R., Mhlanga S., Lopez E. C., Sargent B. F., Somasundaran A., Tamborska A., Webb G., Younas K., Al Sami Y., Babu H., Banks T., Cavallieri F., Cohen M., Davies E., Dhar S., Modol A. F., Farooq H., Harte J., Hey S., Joseph A., Karthikappallil D., Kassahun D., Lipunga G., Mason R., Minton T., Mond G., Poxon J., Rabas S., Soothill G., Zedde M., Yenkoyan K., Brew B., Contini E., Cysique L., Zhang X., Maggi P., van Pesch V., Lechien J., Saussez S., Heyse A., Brito Ferreira M. L., Soares C. N., Elicer I., Eugenin-Von Bernhardi L., Reyes W. N., Yin R., Azab M. A., Abd-Allah F., Elkady A., Escalard S., Corvol J. -C., Delorme C., Tattevin P., Bigaut K., Lorenz N., Hornuss D., Hosp J., Rieg S., Wagner D., Knier B., Lingor P., Winkler A. S., Sharifi-Razavi A., Moein S. T., Seyed Alinaghi S. A., Jamali Moghadam Siahkali S., Morassi M., Padovani A., Giunta M., Libri I., Beretta S., Ravaglia S., Foschi M., Calabresi P., Primiano G., Servidei S., Mercuri N. B., Liguori C., Pierantozzi M., Sarmati L., Boso F., Garazzino S., Mariotto S., Patrick K. N., Costache O., Pincherle A., Klok F. A., Meza R., Cabreira V., Valdoleiros S. R., Oliveira V., Kaimovsky I., Guekht A., Koh J., Diaz E. F., Barrios-Lopez J. M., Guijarro-Castro C., Beltran-Corbellini A., Martinez-Poles J., Diezma-Martin A. M., Morales-Casado M. I., Garcia S. G., Breville G., Coen M., Uginet M., Bernard-Valnet R., Pasquier R. D., Kaya Y., Abdelnour L. H., Rice C., Morrison H., Defres S., Huda S., Enright N., Hassell J., D'Anna L., Benger M., Sztriha L., Raith E., Chinthapalli K., Nortley R., Paterson R., Chandratheva A., Werring D. J., Dervisevic S., Harkness K., Pinto A., Jillella D., Beach S., Gunasekaran K., Ferreira Da Silva I. R., Nalleballe K., Santoro J., Scullen T., Kahn L., Kim C. Y., Thakur K. T., Jain R., Umapathi T., Nicholson T. R., Sejvar J. J., Hodel E. M., Smith C. T., and Solomon T.
- Abstract
Background Neurological COVID-19 disease has been reported widely, but published studies often lack information on neurological outcomes and prognostic risk factors. We aimed to describe the spectrum of neurological disease in hospitalised COVID-19 patients; characterise clinical outcomes; and investigate factors associated with a poor outcome. Methods We conducted an individual patient data (IPD) meta-analysis of hospitalised patients with neurological COVID-19 disease, using standard case definitions. We invited authors of studies from the first pandemic wave, plus clinicians in the Global COVID-Neuro Network with unpublished data, to contribute. We analysed features associated with poor outcome (moderate to severe disability or death, 3 to 6 on the modified Rankin Scale) using multivariable models. Results We included 83 studies (31 unpublished) providing IPD for 1979 patients with COVID-19 and acute new-onset neurological disease. Encephalopathy (978 [49%] patients) and cerebrovascular events (506 [26%]) were the most common diagnoses. Respiratory and systemic symptoms preceded neurological features in 93% of patients; one third developed neurological disease after hospital admission. A poor outcome was more common in patients with cerebrovascular events (76% [95% CI 67–82]), than encephalopathy (54% [42–65]). Intensive care use was high (38% [35–41]) overall, and also greater in the cerebrovascular patients. In the cerebrovascular, but not encephalopathic patients, risk factors for poor outcome included breathlessness on admission and elevated D-dimer. Overall, 30-day mortality was 30% [27–32]. The hazard of death was comparatively lower for patients in the WHO European region. Interpretation Neurological COVID-19 disease poses a considerable burden in terms of disease outcomes and use of hospital resources from prolonged intensive care and inpatient admission; preliminary data suggest these may differ according to WHO regions and country income levels. The dif
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- 2022
48. Anesthetic Management for Patients with Cerebral Palsy
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Koh, J., additional and Aliason, I., additional
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- 2018
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49. Evaluation of the feasibility, diagnostic yield, and clinical utility of rapid genome sequencing in infantile epilepsy (Gene-STEPS): an international, multicentre, pilot cohort study
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D'Gama, AM, Mulhern, S, Sheidley, BR, Boodhoo, F, Buts, S, Chandler, NJ, Cobb, J, Curtis, M, Higginbotham, E, Holland, J, Khan, T, Koh, J, Yliang, NS, Mcrae, L, Nesbitt, SE, Oby, BT, Paternoster, B, Patton, A, Rose, G, Scotchman, E, Valentine, R, Wiltrout, KN, Hayeems, RZ, Jain, P, Lunke, S, Marshall, CR, Rockowitz, S, Sebire, N, Stark, Z, White, SM, Chitty, LS, Cross, JH, Scheffer, IE, Chau, V, Costain, G, Poduri, A, Howell, KB, McTague, A, D'Gama, AM, Mulhern, S, Sheidley, BR, Boodhoo, F, Buts, S, Chandler, NJ, Cobb, J, Curtis, M, Higginbotham, E, Holland, J, Khan, T, Koh, J, Yliang, NS, Mcrae, L, Nesbitt, SE, Oby, BT, Paternoster, B, Patton, A, Rose, G, Scotchman, E, Valentine, R, Wiltrout, KN, Hayeems, RZ, Jain, P, Lunke, S, Marshall, CR, Rockowitz, S, Sebire, N, Stark, Z, White, SM, Chitty, LS, Cross, JH, Scheffer, IE, Chau, V, Costain, G, Poduri, A, Howell, KB, and McTague, A
- Abstract
BACKGROUND: Most neonatal and infantile-onset epilepsies have presumed genetic aetiologies, and early genetic diagnoses have the potential to inform clinical management and improve outcomes. We therefore aimed to determine the feasibility, diagnostic yield, and clinical utility of rapid genome sequencing in this population. METHODS: We conducted an international, multicentre, cohort study (Gene-STEPS), which is a pilot study of the International Precision Child Health Partnership (IPCHiP). IPCHiP is a consortium of four paediatric centres with tertiary-level subspecialty services in Australia, Canada, the UK, and the USA. We recruited infants with new-onset epilepsy or complex febrile seizures from IPCHiP centres, who were younger than 12 months at seizure onset. We excluded infants with simple febrile seizures, acute provoked seizures, known acquired cause, or known genetic cause. Blood samples were collected from probands and available biological parents. Clinical data were collected from medical records, treating clinicians, and parents. Trio genome sequencing was done when both parents were available, and duo or singleton genome sequencing was done when one or neither parent was available. Site-specific protocols were used for DNA extraction and library preparation. Rapid genome sequencing and analysis was done at clinically accredited laboratories, and results were returned to families. We analysed summary statistics for cohort demographic and clinical characteristics and the timing, diagnostic yield, and clinical impact of rapid genome sequencing. FINDINGS: Between Sept 1, 2021, and Aug 31, 2022, we enrolled 100 infants with new-onset epilepsy, of whom 41 (41%) were girls and 59 (59%) were boys. Median age of seizure onset was 128 days (IQR 46-192). For 43 (43% [binomial distribution 95% CI 33-53]) of 100 infants, we identified genetic diagnoses, with a median time from seizure onset to rapid genome sequencing result of 37 days (IQR 25-59). Genetic diagnosis w
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- 2023
50. Endoscopy, video capsule endoscopy, and biopsy for automated celiac disease detection: A review
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Jahmunah, V, En Wei Koh, J, Sudarshan, VK, Raghavendra, U, Gudigar, A, Lih Oh, S, Wen Loh, H, Faust, O, Datta Barua, P, Ciaccio, EJ, Rajendra Acharya, U, Jahmunah, V, En Wei Koh, J, Sudarshan, VK, Raghavendra, U, Gudigar, A, Lih Oh, S, Wen Loh, H, Faust, O, Datta Barua, P, Ciaccio, EJ, and Rajendra Acharya, U
- Abstract
Celiac Disease (CD) is a common ailment that affects approximately 1% of the world population. Automated CD detection can help experts during the diagnosis of this condition at an early stage and bring significant benefits to both patients and healthcare providers. For this purpose, scientists have created automatic and semi-automatic CD diagnostic support systems. In this study, we performed information extraction methods that were found useful for efforts to differentiate CD versus non-CD. To focus the review process, only methods for endoscopy, video capsule endoscopy (VCE) and biopsy image analyses were considered. As described herein, we have learned that statistical and non-linear methods are most important for information extraction. These information extraction tools might benefit clinical workflows by reducing intra- and inter-observer variability. However, bias, introduced by resolving design choices during the creation of diagnostic support systems, may limit the general validity of the performance results, impacting the transferability of study outcomes. Therefore, having am overview of information extraction tools. Together with their general and specific limitations, might be assistive in improving the information extraction process. We hope our review results will provide a foundation for the design of next-generation statistical and nonlinear methods that can be used in CD detection systems. We have also compared various review articles and discussed recommendations to improve CD diagnosis. From this review, it is evident that CD diagnosis is slowly moving away from conventional techniques towards advanced deep learning techniques.
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- 2023
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