1. Meta-analysis of Genome-Wide Association Studies Identifies Novel Loci Associated With Optic Disc Morphology
- Author
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Springelkamp, H. (Henriët), Mishra, A. (Aniket), Hysi, P.G. (Pirro), Gharahkhani, P. (Puya), Höhn, R. (René), Khor, C.C., Cooke Bailey, J.N. (Jessica N.), Luo, X. (Xiaoyan), Ramdas, W.D. (Wishal), Vithana, E.N. (Eranga), Koh, V. (Victor), Yazar, S. (Seyhan), Xu, L. (Liang), Forward, H. (Hannah), Kearns, L.S. (Lisa S.), Amin, N. (Najaf), Iglesias González, A.I. (Adriana), Sim, K.S., Leeuwen, E.M. (Elisa) van, Demirkan, A. (Ayşe), Lee, S.J. (Sven) van der, Loon, S.-C. (Seng-Chee), Rivadeneira Ramirez, F. (Fernando), Nag, A. (Abhishek), Sanfilippo, P.G. (Paul G.), Schillert, A. (Arne), Jong, P.T.V.M. (Paulus) de, Oostra, B.A. (Ben), Uitterlinden, A.G. (André), Hofman, A. (Albert), Zhou, T. (Tiger), Burdon, K.P. (Kathryn), Spector, T.D. (Timothy), Lackner, K.J. (Karl), Saw, S-M. (Seang-Mei), Vingerling, J.R. (Hans), Teo, Y.Y. (Yik Ying), Pasquale, L.R. (Louis), Wolfs, R.C.W. (Roger), Lemij, H.G. (Hans), Tai, E.S. (Shyong), Jonas, J.B. (Jost B.), Cheng, C-Y. (Ching-Yu), Aung, T. (Tin), Jansonius, N.M. (Nomdo), Klaver, C.C.W. (Caroline), Craig, J.E. (Jamie), Young, T.L. (Terri), Haines, J.L. (Jonathan), MacGregor, S. (Stuart), Mackey, D.A. (David), Pfeiffer, A.F.H. (Andreas), Wong, T.Y. (Tien Yin), Wiggs, J.L. (Janey), Hewit, A.W. (Alex), Duijn, C.M. (Cornelia) van, Hammond, C.J. (Christopher), Springelkamp, H. (Henriët), Mishra, A. (Aniket), Hysi, P.G. (Pirro), Gharahkhani, P. (Puya), Höhn, R. (René), Khor, C.C., Cooke Bailey, J.N. (Jessica N.), Luo, X. (Xiaoyan), Ramdas, W.D. (Wishal), Vithana, E.N. (Eranga), Koh, V. (Victor), Yazar, S. (Seyhan), Xu, L. (Liang), Forward, H. (Hannah), Kearns, L.S. (Lisa S.), Amin, N. (Najaf), Iglesias González, A.I. (Adriana), Sim, K.S., Leeuwen, E.M. (Elisa) van, Demirkan, A. (Ayşe), Lee, S.J. (Sven) van der, Loon, S.-C. (Seng-Chee), Rivadeneira Ramirez, F. (Fernando), Nag, A. (Abhishek), Sanfilippo, P.G. (Paul G.), Schillert, A. (Arne), Jong, P.T.V.M. (Paulus) de, Oostra, B.A. (Ben), Uitterlinden, A.G. (André), Hofman, A. (Albert), Zhou, T. (Tiger), Burdon, K.P. (Kathryn), Spector, T.D. (Timothy), Lackner, K.J. (Karl), Saw, S-M. (Seang-Mei), Vingerling, J.R. (Hans), Teo, Y.Y. (Yik Ying), Pasquale, L.R. (Louis), Wolfs, R.C.W. (Roger), Lemij, H.G. (Hans), Tai, E.S. (Shyong), Jonas, J.B. (Jost B.), Cheng, C-Y. (Ching-Yu), Aung, T. (Tin), Jansonius, N.M. (Nomdo), Klaver, C.C.W. (Caroline), Craig, J.E. (Jamie), Young, T.L. (Terri), Haines, J.L. (Jonathan), MacGregor, S. (Stuart), Mackey, D.A. (David), Pfeiffer, A.F.H. (Andreas), Wong, T.Y. (Tien Yin), Wiggs, J.L. (Janey), Hewit, A.W. (Alex), Duijn, C.M. (Cornelia) van, and Hammond, C.J. (Christopher)
- Abstract
Primary open-angle glaucoma is the most common optic neuropathy and an important cause of irreversible blindness worldwide. The optic nerve head or optic disc is divided in two parts: a central cup (without nerve fibers) surrounded by the neuroretinal rim (containing axons of the retinal ganglion cells). The International Glaucoma Genetics Consortium conducted a meta-analysis of genome-wide association studies consisting of 17,248 individuals of European ancestry and 6,841 individuals of Asian ancestry. The outcomes of the genome-wide association studies were disc area and cup area. These specific measurements describe optic nerve morphology in another way than the vertical cup-disc ratio, which is a clinically used measurement, and may shed
- Published
- 2015
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