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3 results on '"Kohshi Narasaki"'

1. The Effect of High-concentration Insulin Glarigine on the Quality of Life of Patients with Type 2 Diabetes Mellitus: A Pre-post Study (HIGH-QOL STUDY)

Author

Miho Tsuruo, Kenji Kamiuchi, Hideaki Sawaki, Akiko Suganuma, Moritsugu Kimura, Masao Toyoda, Naoki Sakane, Satoshi Kawashima, Kensou Osawa, Takashi Murata, Ryuji Kouyama, Ken Kato, Kohshi Narasaki, Atsuhito Tone, and Tomokazu Watanabe

Subjects
Adult, Male, medicine.medical_specialty, concentration, Psychometrics, Visual analogue scale, type 2 diabetes mellitus, medicine.medical_treatment, Drug Compounding, Injections, Subcutaneous, Insulin Glargine, Pain, 030204 cardiovascular system & hematology, Drug Administration Schedule, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Internal medicine, Internal Medicine, medicine, Humans, Hypoglycemic Agents, Aged, Pain Measurement, High concentration, Aged, 80 and over, Pain score, business.industry, Insulin glargine, Insulin, Significant difference, Type 2 Diabetes Mellitus, Patient Preference, General Medicine, Middle Aged, Diabetes Mellitus, Type 2, injection, Quality of Life, 030211 gastroenterology & hepatology, Female, Original Article, business, medicine.drug
Abstract

Objective We compared the pain accompanying the injection of high-concentration (300 units/mL) insulin glargine (U300G) with that accompanying the injection of conventional (100 units/mL) insulin glargine (U100G). Methods U100G was switched to U300G at basically the same dosage. Visual analog scales were used to assess the quality of life (QOL). The primary outcome was the change in the pain accompanying injections in those using ≥30 units of U100G compared with those using

Published
2019

2. Fibrillin gene (FBN1) mutations in Japanese patients with Marfan syndrome

Author

Eiji Nanba, Toshiyuki Yamamoto, Kimiyo Ono, Tatsuo Katoh, Keiko Nagata, Haruaki Ninomiya, Shigetsugu Ohgi, Yasutoshi Ohta, Hiroaki Kuroda, Ichiro Hisatome, Hiroki Chikumi, Kohshi Narasaki, and Yoshiyuki Tanaka

Subjects
Male, musculoskeletal diseases, Marfan syndrome, congenital, hereditary, and neonatal diseases and abnormalities, Fibrillin-1, RNA Splicing, DNA Mutational Analysis, Mutation, Missense, Biology, Fibrillins, medicine.disease_cause, Polymerase Chain Reaction, Marfan Syndrome, Chromosome 15, Exon, Genetics, medicine, Humans, Missense mutation, skin and connective tissue diseases, Polymorphism, Single-Stranded Conformational, Genetics (clinical), Sequence Deletion, Extracellular Matrix Proteins, Mutation, Microfilament Proteins, Single-strand conformation polymorphism, DNA, Exons, Middle Aged, medicine.disease, Molecular biology, Exon skipping, Amino Acid Substitution, Female, Fibrillin
Abstract

Marfan syndrome (MFS; MIM #154700) is a connective tissue disorder characterized by cardiovascular, skeletal, and ocular abnormalities. The fibrillin-1 gene (FBN1; MIM no. 134797) on chromosome 15 was revealed to be the cause of Marfan syndrome. To date over 137 types of FBN1 mutations have been reported. In this study, two novel mutations and a recurrent de-novo mutation were identified in patients with MFS by means of single-strand conformational polymorphism (SSCP) analysis. The two novel mutations are a 4-bp deletion at nucleotide 2820-2823 and a G-to-T transversion at nucleotide 1421 (C474F), located on exon 23 and exon 11, respectively. A previously reported mutation at the splicing donor site of intron 2 (IVS2 G + 1A), which is predicted to cause exon skipping, was identified in a sporadic patient with classical MFS.

Published
2000
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3. Quinidine enhances intracellular Ca2+ accumulation during rapid stimulation

Author

Hiroto Mashiba, Mariko Tsuboi, Takahiro Nawada, Hiroshi Kotake, Shozo Hirai, Junichi Hasegawa, and Kohshi Narasaki

Subjects
Quinidine, medicine.medical_specialty, Fura-2, Systole, Guinea Pigs, chemistry.chemical_element, Stimulation, In Vitro Techniques, Calcium, Intracellular ca, chemistry.chemical_compound, Caffeine, Internal medicine, medicine, Animals, Pharmacology, Myocardium, Time constant, Heart, Electric Stimulation, Endocrinology, chemistry, Biophysics, Intracellular, medicine.drug
Abstract

1. 1. The quinidine-induced modification of intracellular Ca 2+ concentration ([Ca 2+ ] i ) was studied in guinea-pig myocardium using fura-2. Quinidine reduced the systolic fluorescence signal level for [Ca 2+ ] i and enhanced the end-diastolic signal level during a stimulation train. 2. 2. The diastolic decay of [Ca 2+ ] i fitted 2 exponential curves. Quinidine distorted the stimulation frequency-dependent acceleration of rapid [Ca 2+ ] i decay, and prolonged the mean time constant of rapid decay after 2 Hz stimulation, from 154.4 to 205.3 msec (20 μM), and to 259.7 msec (60 μM quinidine). The time constant of slow recovery from [Ca 2+ ] i accumulation after the stimulation train was not affected by stimulation frequency, or by quinidine, or caffeine. 3. 3. These results suggest that quinidine modulates [Ca 2+ ] i via a balance between the slowing of rapid [Ca 2+ ] i decay and the reduction of the systolic [Ca 2+ ] i . This effect may contribute to the anti-arrhythmic and pro-arrhythmic effects exerted by quinidine in some conditions.

Published
1995
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