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162 results on '"Koide, Masahiro"'

2. DAPagliflozin for the attenuation of albuminuria in Patients with hEaRt failure and type 2 diabetes (DAPPER study): a multicentre, randomised, open-label, parallel-group, standard treatment-controlled trial

Author

Yoshihara, Fumiki, Imazu, Miki, Kawabata, Takanori, Omae, Katsuhiro, Izumi, Chisato, Kanzaki, Hideaki, Amaki, Makoto, Okada, Atsushi, Amano, Masashi, Moriuchi, Kenji, Ito, Shin, Hosoda, Kiminori, Makino, Hisashi, Omura-Ohata, Yoko, Tamanaha, Tamiko, Koezuka, Ryo, Noguchi, Michio, Arisato, Tetsuya, Noguchi, Teruo, Tahara, Yoshio, Kataoka, Yu, Asaumi, Yasuhide, Fujino, Masashi, Otsuka, Fumiyuki, Yoneda, Shuichi, Honda, Satoshi, Miura, Hiroyuki, Sakuma, Ichiro, Hiroi, Yukio, Hara, Hisao, Yamamoto, Masaya, Okazaki, Toru, Nakagawa, Takashi, Kubota, Shuji, Torii, Shunsuke, Yamamoto, Jumpei, Miyake, Wataru, Nagai, Ran, Ishiwata, Mai, Okazaki, Osamu, Ishiguro, Chizuru, Shiraiwa, Toshihiko, Nishioka, Norio, Maeno, Yoshifumi, Yamamoto, Kaoru, Yoshida, Yoko, Shiraiwa, Yuka, Fujii, Kenshi, Iwakura, Katsuomi, Okamura, Atsunori, Hirao, Yuko, Tanaka, Koji, Iwamoto, Mutsumi, Tanaka, Nobuaki, Okada, Masato, Sumiyoshi, Akinori, Tanaka, Kota, Watanabe, Satoshi, Harada, Shinichi, Kashiyama, Toshikazu, Tomonaga, Osamu, Kobayashi, Koichi, Ishiki, Ryoji, Yamamoto, Dai, Ito, Tadahiro, Takihata, Masahiro, Yumoto, Kazuhiko, Fukuzawa, Tomoyuki, Takase, Hiroyuki, Hayashi, Kazusa, Himi, Toshiharu, Hyodo, Yusuke, Ishibashi, Ryoichi, Shimizu, Ikki, Murakami, Tsutomu, Ikari, Yuji, Ohno, Yohei, Sakama, Susumu, Nakamura, Norihito, Miyamoto, Junichi, Torii, Sho, Ijichi, Takeshi, Lee, Kyong Hee, Wagatsuma, Kenji, Nii, Hideo, Uchida, Yasuto, Sato, Katsuhiko, Hiramatsu, Takeyuki, Takada, Yasunobu, Akabame, Satoshi, Koide, Masahiro, Kitajima, Hiroki, Kato, Yukinori, Sogabe, Koji, Fukui, Kento, Kogure, Masaya, Kishi, Akio, Hata, Shiro, Shinboku, Hiroki, Muroya, Takahiro, Sonoda, Koichiro, Asakura, Masanori, and Kitakaze, Masafumi

Published
2023
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20. Replicative senescence of vascular smooth muscle cells enhances the calcification through initiating the osteoblastic transition

Author

Nakano-Kurimoto, Ritsuko, Ikeda, Koji, Uraoka, Maki, Nakagawa, Yusuke, Yutaka, Kotaro, Koide, Masahiro, Takahashi, Tomosaburo, Matoba, Satoaki, Yamada, Hiroyuki, Okigaki, Mitsuhiko, and Matsubara, Hiroaki

Subjects
Vascular smooth muscle -- Physiological aspects, Vascular smooth muscle -- Research, Transcription factors -- Physiological aspects, Transcription factors -- Research, Calcification -- Research, Aging -- Physiological aspects, Aging -- Research, Biological sciences
Abstract

Medial artery calcification, which does not accompany lipid or cholesterol deposit, preferentially occurs in elderly population, but its underlying mechanisms remain unclear. In the present study, we investigated the potential role of senescent vascular smooth muscle cells (VSMCs) in the formation of senescence-associated medial calcification. Replicative senescence was induced by the extended passages (until passages 11-13) in human primary VSMCs, and cells in early passage (passage 6) were used as control young cells. VSMC calcification was markedly enhanced in the senescent cells compared with that in the control young cells. We identified that genes highly expressed in osteoblasts, such as alkaline phosphatase (ALP) and type I collagen, were significantly upregulated in the senescent VSMCs, suggesting their osteoblastic transition during the senescence. Knock-down of either ALP or type I collagen significantly reduced the calcification in the senescent VSMCs. Of note, runt-related transcription factor-2 (RUNX-2), a core transcriptional factor that initiates the osteoblastic differentiation, was also upregulated in the senescent VSMCs. Knockdown of RUNX-2 significantly reduced the ALP expression and calcification in the senescent VSMCs, suggesting that RUNX-2 is involved in the senescence-mediated osteoblastic transition. Furthermore, immunohistochemistry of aorta from the [klotho.sup.-/-] aging mouse model demonstrated in vivo emergence of osteoblast-like cells expressing RUNX-2 exclusively in the calcified media. We also found that statin and Rho-kinase inhibitor effectively reduced the VSMC calcification by inhibiting [P.sub.i]-induced apoptosis and potentially enhancing matrix Gla protein expression in the senescent VSMCs. These findings strongly suggest an important role of senescent VSMCs in the pathophysiology of senescence-associated medial calcification, and the inhibition of osteoblastic transition could be a new therapeutic approach for the prevention of senescence-associated medial calcification. runt-related transcription factor-2; statin doi: 10.1152/ajpheart.00455.2009.

Published
2009

21. Electrophoretic cell manipulation and electrochemical gene-function analysis based on a yeast two-hybrid system in a microfluidic device

Author

Yasukawa, Tomoyuki, Nagamine, Kuniaki, Horiguchi, Yoshiko, Shiku, Hitoshi, Koide, Masahiro, Itayama, Tomoaki, Shiraishi, Fujio, and Matsue, Tomokazu

Subjects
Fluidic devices -- Design and construction, Fluidic devices -- Usage, Gene expression -- Research, Cell physiology -- Research, Electrochemistry -- Research, Electrophoresis -- Research, Chemistry
Abstract

A novel microfluidic device with an array of analytical chambers was developed in order to perform single-cell-based gene-function analysis. A series of analytical processes was carried out using the device, including electrophorefic manipulation of single cells and electrochemical measurement of gene function. A poly(dimethylsiloxane) microstructure with a microfluidic channel (150 [micro]m in width, 10 [micro]m in height) and an analytical chamber (100 x 20 x 10[micro][m.sup.3]) were fabricated and aligned on a glass substrate with an array of Au microelectrodes. Two microelectrodes positioned in the analytical chamber were employed as a working electrode for the electrophoretic manipulation of cells and electrochemical measurements. A yeast strain (Saccharomyces cerevisiae Y190) carrying the [beta]-galactosidase reporter gene was used to demonstrate that the device could detect the enzyme. Target cells flowing through the main channel were introduced into the chamber by electrophoresis using the ground electrode laid on the main channel. When the cell was treated with 17[beta]-estradiol, gene expression was triggered to produce [beta]-galactosidase, catalyzing the hydrolysis of p-aminophenyl-[beta]-D-galactopyranoside to form p-aminophenol (PAP). The enzymatically generated PAP was detected by cyclic voltammetry and amperometry at the single-cell level in the chamber of the device. Generator-collector mode amperometry was also applied to amplify the current response originating from gene expression in the trapped single cells. After electrochemical measurement, the trapped cells were easily released from the chamber using electrophoretic force.

Published
2008

23. Extraordinary Delayed-Onset Negative Pressure Pulmonary Hemorrhage Resulting in Cardiac Arrest after General Anesthesia for Vocal Cord Polypectomy

Author

Koide, Masahiro, Kitada, Tatsuya, Kogure, Masaya, Fukui, Kento, Sogabe, Koji, Kato, Yukinori, Kitajima, Hiroki, and Akabame, Satoshi

Subjects
Article Subject
Abstract

Negative pressure pulmonary edema and hemorrhage are uncommon but potentially life-threatening complications associated with general anesthesia. Postoperative negative pressure pulmonary edema usually occurs immediately after surgery, and delayed-onset cases occurring more than 1 hour after surgery have rarely been reported. A 37-year-old woman with bronchial asthma underwent vocal cord polypectomy under general anesthesia in another hospital and experienced cardiac arrest due to a negative pressure pulmonary hemorrhage occurring 3 hours and 30 minutes after surgery. She was successfully treated with venoarterial extracorporeal membrane oxygenation and completely recovered without any complications. Extraordinary delayed-onset negative pressure pulmonary hemorrhage occurring more than three hours after surgery has rarely been reported. This case may indicate the need for more careful observation of patients following surgery.

Published
2020
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30. Identification of intracellular squalene in living algae, Aurantiochytrium mangrovei with hyper-spectral coherent anti-Stokes Raman microscopy using a sub-nanosecond supercontinuum laser source

Author

Ishitsuka, Kei, Koide, Masahiro, Yoshida, Masaki, Segawa, Hiroki, Leproux, Philippe, Couderc, Vincent, Watanabe, Makoto M., and Kano, Hideaki

Subjects
lipids (amino acids, peptides, and proteins)
Abstract

We applied hyper-spectral coherent anti-Stokes Raman scattering imaging to intracellular lipid identification in living microalgae, Aurantiochytrium mangrovei 18W-13a. Two different lipids, squalene and triacylglycerol, were found inside living cells with clear vibrational contrast. Based on the endogenous lipid band as a result of the cis C[DOUBLE BOND]C stretch vibrational mode, squalene and triacylglycerol were clearly distinguished in different intracellular areas. In particular, squalene was detected solely in vacuoles as lipid particles, which was also supported by electron microscopy.

Published
2017

31. Current abstracts of the articles published in The Japanese journal of nuclear medicine

Author

Ito, Kazuki, Kinoshita, Noriyuki, Koide, Masahiro, Yokoi, Hirokazu, Irie, Hidekazu, Hashimoto, Tetsuo, Tamaki, Shunichi, Nishikawa, Susumu, Azuma, Akihiro, Matsubara, Hiroaki, Hayashi, Katsumi, Abe, Katsumi, Sakata, Ikuko, Sakaguchi, Chiharu, Yamamoto, Kentaro, Kosuda, Shigeru, Mitsuyama, Hayato, Abe, Masahiro, Iino, Hitoshi, Fujinawa, Manabu, Yamashita, Akira, Watanabe, Hirofumi, Sugihara, Hiroshi, Horiuchi, Masahiro, Takahashi, Yoichi, and Tajiri, Junichi

Published
2005
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35. Cholesterol crystal depth in coronary atherosclerotic plaques: A novel index of plaque vulnerability using optical frequency domain imaging

Author

Koide, Masahiro, primary, Matsuo, Akiko, additional, Shimoo, Satoshi, additional, Takamatsu, Kazuaki, additional, Kyodo, Atsushi, additional, Tsuji, Yumika, additional, Mera, Kayoko, additional, Tsubakimoto, Yoshinori, additional, Isodono, Koji, additional, Sakatani, Tomohiko, additional, Inoue, Keiji, additional, and Fujita, Hiroshi, additional

Published
2017
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36. Successful Complete Revascularization With PCI Using Super-Low Volume of Contrast Medium in a Patient With Three-Vessel Disease Including 2 Chronic Total Occlusions With Severe Renal Dysfunction

Author

Koide, Masahiro, primary, Kato, Masayuki, additional, Usui, Kimihito, additional, Mera, Kayoko, additional, Tsubakimoto, Yoshinori, additional, Isodono, Koji, additional, Sakatani, Tomohiko, additional, Matsuo, Akiko, additional, Inoue, Keiji, additional, and Fujita, Hiroshi, additional

Published
2017
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37. Visualization of the improvement of myocardial perfusion after coronary intervention using motorized fractional flow reserve pullback curve

Author

Matsuo, Akiko, primary, Shimoo, Satoshi, additional, Takamatsu, Kazuaki, additional, Tsuji, Yumika, additional, Kyodo, Atsushi, additional, Mera, Kayoko, additional, Koide, Masahiro, additional, Isodono, Koji, additional, Tsubakimoto, Yoshinori, additional, Sakatani, Tomohiko, additional, Inoue, Keiji, additional, and Fujita, Hiroshi, additional

Published
2016
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43. Manipulation of Cardiac Phosphatidylinositol 3-Kinase (PI3K)/Akt Signaling by Apoptosis Regulator through Modulating IAP Expression (ARIA) Regulates Cardiomyocyte Death during Doxorubicin-induced Cardiomyopathy

Author

Kitamura, Youhei, primary, Koide, Masahiro, additional, Akakabe, Yoshiki, additional, Matsuo, Kiyonari, additional, Shimoda, Yoshiaki, additional, Soma, Yuka, additional, Ogata, Takehiro, additional, Ueyama, Tomomi, additional, Matoba, Satoaki, additional, Yamada, Hiroyuki, additional, and Ikeda, Koji, additional

Published
2014
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44. Intracoronary Transplantation of Non-Expanded Peripheral Blood-Derived Mononuclear Cells Promotes Improvement of Cardiac Function in Patients With Acute Myocardial Infarction

Author

Tatsumi, Tetsuya, primary, Ashihara, Eishi, additional, Yasui, Toshihide, additional, Matsunaga, Shinsaku, additional, Kido, Atsumichi, additional, Sasada, Yuji, additional, Nishikawa, Satoshi, additional, Hadase, Mitsuyoshi, additional, Koide, Masahiro, additional, Nakamura, Reo, additional, Irie, Hidekazu, additional, Ito, Kazuki, additional, Matsui, Akihiro, additional, Matsui, Hiroyuki, additional, Katamura, Maki, additional, Kusuoka, Shigehiro, additional, Matoba, Satoaki, additional, Okayama, Satoshi, additional, Horii, Manabu, additional, Uemura, Shiro, additional, Shimazaki, Chihiro, additional, Tsuji, Hajime, additional, Saito, Yoshihiko, additional, and Matsubara, Hiroaki, additional

Published
2014
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49. Loss of Bcl-2 During the Senescence Exacerbates the Impaired Angiogenic Functions in Endothelial Cells by Deteriorating the Mitochondrial Redox State

Author

Uraoka, Maki, primary, Ikeda, Koji, additional, Kurimoto-Nakano, Ritsuko, additional, Nakagawa, Yusuke, additional, Koide, Masahiro, additional, Akakabe, Yoshiki, additional, Kitamura, Youhei, additional, Ueyama, Tomomi, additional, Matoba, Satoaki, additional, Yamada, Hiroyuki, additional, Okigaki, Mitsuhiko, additional, and Matsubara, Hiroaki, additional

Published
2011
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