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1,086 results on '"Koike, Kazuo"'

13. Proton Decay and Sub-Structure

Author

Koike, Kazuo

Subjects
High Energy Physics - Phenomenology
Abstract

The problem of elementarity of electric charge is investigated. It is known that possible proton decay is caused by $X$ and $Y$ bosons which are characteristic in GUTs. The charge structure of GUTs is, however, not simple, and the five types of charge units appear. We investigate the problem of elementarity in taking into account of the simplest model of the charge structure known as the rishon model, where the charge units are known as 1/3 ($T$) and 0 ($V$). In order to approach to sub-structure together with the problem of simplicity of charge structure, possible rearrangements of rishons are investigated on the basis of color and hypercolor confinement condition. Further, possible existence of the simplest electroweak sub-structure is discussed. Our model predicts possible proton decay mode, in which $X$ and $Y$ bosons are not concerned., Comment: 5 pages, 4 figures

Published
2006

16. A Model of Hot-Sector Generations

Author

Koike, Kazuo

Subjects
High Energy Physics - Phenomenology
Abstract

Possible existence of "hot-sector generations" above the well known 3 generation bound is investigated on the basis of a model of leptons and quarks, which is based on the Harari and Shupe's one. Our model predicts the existence of {\bf3 + 1} generations above the ordinary "cold-sector" 3 generations. Majorana neutrinos are introduced to realize the heavy neutrino masses in hot-sector generations. Properties of heavy neutrinos are also discussed., Comment: 16 pages, no figure Miss types of suffix in Eqs.(7)-(10) are fixed

Published
2002

18. See-saw Mechanism and Possible Generation Structure

Author

Koike, Kazuo

Subjects
High Energy Physics - Phenomenology
Abstract

On the basis of see-saw mechanism, possible generation structure is investigated. Assuming that right-handed neutrinos are realistic particles below GUTs mass, it is shown that there is a choice of new scheme of generation,where the combination of leptons and quarks is different from the ordinary one. Our scheme predict a new proton decay mode., Comment: 9 pages

Published
1999

33. Correction to: Identification of β‑carboline and canthinone alkaloids as anti‑inflammatory agents but with different inhibitory profile on the expression of iNOS and COX‑2 in lipopolysaccharide‑activated RAW 264.7 macrophages

Author

Liu, Pan, Li, Huixiang, Luan, Ruiling, Huang, Guiyan, Liu, Yanan, Wang, Mengdi, Chao, Qiuli, Wang, Liying, Li, Danna, Fan, Huaying, Chen, Daquan, Li, Linyu, Matsuzaki, Keiichi, Li, Wei, Koike, Kazuo, and Zhao, Feng

Published
2019
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34. Intellectual Skills and Competitive Strength: Is a Radical Change Necessary?

Author

Koike, Kazuo

Abstract

Data from a study of Toyota production workshops show the most important worker intellectual skills are problem-solving know-how and ability to handle change. Introduction of information technology elevates the need for intellectual skills because of uncertainty. Development of skills for dealing with uncertainty and change in both blue- and white-collar workers increases efficiency. (Contains 14 references.) (SK)

Published
2002

43. Identification of β-carboline and canthinone alkaloids as anti-inflammatory agents but with different inhibitory profile on the expression of iNOS and COX-2 in lipopolysaccharide-activated RAW 264.7 macrophages

Author

Liu, Pan, Li, Huixiang, Luan, Ruiling, Huang, Guiyan, Liu, Yanan, Wang, Mengdi, Chao, Qiuli, Wang, Liying, Li, Danna, Fan, Huaying, Chen, Daquan, Li, Linyu, Matsuzaki, Keiichi, Li, Wei, Koike, Kazuo, and Zhao, Feng

Subjects
iNOS, Original Paper, Anti-inflammatory activity, 010404 medicinal & biomolecular chemistry, 010405 organic chemistry, Canthinone alkaloid, Molecular Medicine, PGE2, β-Carboline alkaloid, COX-2, 01 natural sciences, NO, 0104 chemical sciences
Abstract

A compound library, which consists of 75 natural β-carboline-type or canthinone-type alkaloids from Simaroubaceae plants and their chemical synthetic analogues, was screened for the anti-inflammatory activity by inhibition of the overproduction of inflammatory mediator nitric oxide (NO) in lipopolysaccharide (LPS)-activated RAW 264.7 macrophage cells. Six compounds, namely, benzalharman (23), kumujian (27), 1-ethyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (37), 1-acetophenone-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (42), cathin-6-one (46), and 9-methoxy-cathin-6-one (57), exhibited significant inhibitory activity on the overproduction of NO with good dose dependency. Further investigation demonstrated that all of the six compounds down-regulated the high expression of inducible nitric oxide synthase (iNOS) protein. Among them, two canthinone-type alkaloids (46 and 57) potently down-regulated cyclooxygenase-2 (COX-2) protein expression in a dose-dependent manner and also inhibited the overproduction of inflammatory mediator prostaglandin E2 (PGE2). However, the β-carboline-type alkaloids (23, 27, 37, and 42) exhibited no obvious inhibition on the overproduction of PGE2 and the expression of COX-2 protein. The results suggested that β-carboline-type alkaloids and canthinone-type alkaloids may exert an anti-inflammatory effect through different mechanism. Electronic supplementary material The online version of this article (10.1007/s11418-018-1251-5) contains supplementary material, which is available to authorized users.

Published
2018

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