12 results on '"Koji Namiguchi"'
Search Results
2. Comparison of success rates in eye drop instillation between sitting position and supine position.
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Tomoko Naito, Keiji Yoshikawa, Koji Namiguchi, Shiro Mizoue, Atsushi Shiraishi, Yuko Ichikawa, Miyuki Fujiwara, Takako Miki, Ryoichi Araki, Yuzo Umeda, Yuki Morizane, and Fumio Shiraga
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Medicine ,Science - Abstract
PURPOSE:To compare the success rates of eye drop instillation in the sitting position and supine position among Japanese patients with ocular diseases (cataract, glaucoma, or retinal and vitreous diseases). METHODS:Patients who were hospitalized in Okayama University Hospital for eye surgery were studied. Instillation procedures of each patient in both the sitting and supine positions were recorded using a video camera at the time of instillation. We defined "success" when one drop fell accurately onto the ocular surface at the first attempt. Instillation of two or more drops, drops delivered to a site other than the eye surface, and touching the eyelashes, eyelids, or conjunctiva with the tip of the eye drop bottle were regarded as "failure". We excluded patients with vision below counting finger. RESULTS:One-hundred and two patients (54 males and 58 females, aged 70.2 ± 12.3 years) with ocular disease who were hospitalized for surgery (cataract: 61.8%, glaucoma: 15.7%, retinal and vitreous diseases: 22.5%) were included in this prospective observational study. The mean duration of eye drop use was 3.1 ± 5.2 years. The success rate of eye drop instillation was significantly higher in the supine position than in the sitting position (64.7% vs. 50%, P = 0.0039). The mean age was significantly higher in the failure group than in the success group (74.0 ± 11.5 vs. 67.7 ± 12.4 years, P = 0.0085) for the sitting position, but not significantly different for the supine position (72.3 ± 12.9 vs. 70.1 ± 12.0 years, P = 0.3849). No significant differences in mean duration of drop use, mean corrected VA, and mean spherical equivalent refraction were observed between success and failure groups, for both sitting and supine positions. CONCLUSIONS:In the present study, the success rate of eye drop instillation was significantly higher when applied in the supine position than in the sitting position.
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- 2018
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3. Factors affecting eye drop instillation in glaucoma patients with visual field defect.
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Tomoko Naito, Koji Namiguchi, Keiji Yoshikawa, Kazuhisa Miyamoto, Shiro Mizoue, Yoichi Kawashima, Atushi Shiraishi, and Fumio Shiraga
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Medicine ,Science - Abstract
To investigate the success rate of eye drop instillation in glaucoma patients with visual field defect as well as non-glaucoma volunteers. Factors that may affect the success rate of eye drop instillation were also evaluated.A prospective, observational study.Seventy-eight glaucoma patients and 85 non-glaucoma volunteers were recruited in this study.Open angle glaucoma patients with visual field defect as well as non-glaucoma volunteers were asked to video record their procedures of eye drop instillation using a 5-mL plastic bottle of artificial tear solution. Success of eye drop instillation was judged on video based on the first one drop of solution successfully applied on the cornea, by two investigators.Success rate of eye drop instillation in glaucoma patients and non-glaucoma volunteers. Factors related to success rate of eye drop instillation, such as visual field defect and clinical characteristics, were also analyzed using multivariable logistic regression.No significant deference in mean age was observed between two groups (glaucoma: 64.5 ± 14.4 years, non-glaucoma: 60.9 ± 14.1 years, P = 0.1156). Success rate of eye drop instillation was significantly lower (P = 0.0215) in glaucoma patients (30/78; 38.5%) than in non-glaucoma volunteers (48/85; 56.5%). The most frequent reason of instillation failure in glaucoma patients was touching the bulbar conjunctiva, cornea, eyelid or eyelashes with the tip of the bottle (29.5%). Multivariable logistic regression analysis identified lower corrected visual acuity (VA) (≤ 1.0; odds ratio [OR] = 0.20, 95% confidence interval [CI] 0.04-0.93, P = 0.0411), lower mean deviation (MD) (< -12 dB; OR = 0.20, 95% CI 0.05-0.86, P = 0.0307) and visual field defect (VFD) in the inferior hemifield (OR = 0.11, 95% CI 0.02-0.34, P < 0.001) to be significantly related to instillation failure in glaucoma patients.Success rate of eye drop instillation was significantly lower in glaucoma patients than in non-glaucoma volunteers. Corrected VA ≤ 1.0, MD < -12 dB and/or VFD in the inferior hemifield may be related to failure of eye drop instillation.
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- 2017
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4. Changes in Anterior Segment Morphology of Iris Bombe before and after Laser Peripheral Iridotomy in Patients with Uveitic Secondary Glaucoma
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Wakako Ikegawa, Takashi Suzuki, Koji Namiguchi, Shiro Mizoue, Atsushi Shiraishi, and Yuichi Ohashi
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Ophthalmology ,RE1-994 - Abstract
Purpose. To quantify changes in anterior segment (AS) parameters after laser peripheral iridotomy (LPI) using AS-optical coherence tomography (OCT) of iris bombe. Method. AS images of eight eyes were captured before and after iris bombe and more than 2 weeks after LPI (post-LPI) using AS-OCT. We compared the following AS parameters: anterior chamber depth (ACD), anterior chamber volume (ACV), iris curvature (IC), iris thickness at 500 μm from the scleral spur (IT-1) in the middle between the iris root and pupillary margin (IT-2) and 500 μm from the pupillary margin (IT-3) to the anterior chamber angle (ACA) (angle opening distance [AOD750]), and trabecular iris space area. Results. Mean IT-1 and IT-3, but not IT-2, were lower after iris bombe (IT-1, P=0.001; IT-2, P=0.081; and IT-3, P=0.001). There were no significant differences between ACD at pre-LPI and before iris bombe (P=0.096). The mean ACV and AOD750 of iris bombe increased at post-LPI (ACV, P
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- 2016
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5. Noninferiority of Microhook to Trabectome
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Sotaro Mori, Masaki Tanito, Nobuyuki Shoji, Yu Yokoyama, Takanori Kameda, Takuhei Shoji, Shiro Mizoue, Yuta Saito, Kyoko Ishida, Toshihiko Ueda, Makoto Nakamura, Koji Namiguchi, Kenji Inoue, Yusuke Kono, Masayuki Kasahara, Matsumiya Wataru, Nagai Takayuki, Akagi Tadamichi, Jun Makita, Michihiro Kono, Kota Yokoyama, and Toru Nakazawa
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medicine.medical_specialty ,Intraocular pressure ,genetic structures ,Minimally invasive glaucoma surgery ,business.industry ,medicine.medical_treatment ,Glaucoma ,General Medicine ,Cataract surgery ,medicine.disease ,Trabeculotomy ,eye diseases ,Ophthalmology ,Propensity score matching ,Glaucoma surgery ,Medicine ,Trabectome ,sense organs ,business - Abstract
Purpose To elucidate the non-inferiority of ab interno microhook trabeculotomy (μTLO) using a recently developed reusable stainless spatula-type microhook device to incise the trabecular meshwork to trabectome (TOM) in terms of the 1-year postoperative outcomes of Japanese patients with glaucoma by means of propensity score analyses. Design A multicenter retrospective cohort study. Participants We enrolled 553 and 392 patients who underwent TOM and μTLO, respectively, between January 2014 and March 2020 at 10 facilities. Methods Logistic regression analysis was conducted to calculate the propensity score, which indicates the likelihood of treatment assignment (TOM or μTLO). We set the following factors as outcome-related covariates: age, sex, facility, glaucoma disease types, preoperative intraocular pressure (IOP), glaucoma drug score, mean deviation of the Humphrey visual field test and antithrombotic drug use, the presence or absence of combined cataract surgery, and incision range of trabecular meshwork (one or two quadrants). We analyzed four different methods (matching, inverse probability of treatment weighting (IPTW), stratification, and regression adjustment) using the propensity score. We set 15% as the non-inferiority margin based on previous trabectome meta-analysis results. Main outcome measures The primary outcome was surgical success at 1 year postoperatively. We defined surgical success as satisfying all three criteria: (1) IOP within 5–21 mmHg; (2) IOP reduction of ≥20% from preoperative IOP; and (3) no additional glaucoma surgery. Results The 95% confidence interval of risk difference of surgical failure in μTLO in reference to TOM was −12.1 to +9.5% in matching, −12.7 to +11.1% in IPTW, −12.2 to +7.0 in stratification, and −9.7 to +8.1% in regression adjustment, all of which fell within the predetermined non-inferiority margin of 15%. Conclusions Surgical success of μTLO at 1-year postoperatively was not inferior to that of TOM.
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- 2022
6. Noninferiority of Microhook to Trabectome: Trabectome versus Ab Interno Microhook Trabeculotomy Comparative Study (Tram Trac Study)
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Sotaro, Mori, Masaki, Tanito, Nobuyuki, Shoji, Yu, Yokoyama, Takanori, Kameda, Takuhei, Shoji, Shiro, Mizoue, Yuta, Saito, Kyoko, Ishida, Toshihiko, Ueda, Makoto, Nakamura, Koji, Namiguchi, Kenji, Inoue, Yusuke, Kono, Masayuki, Kasahara, Matsumiya, Wataru, Nagai, Takayuki, Akagi, Tadamichi, Jun, Makita, Michihiro, Kono, Kota, Yokoyama, and Toru, Nakazawa
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Tonometry, Ocular ,Trabecular Meshwork ,Humans ,Multicenter Studies as Topic ,Glaucoma ,Trabeculectomy ,Retrospective Studies - Abstract
To elucidate the noninferiority of ab interno microhook trabeculotomy (μTLO) using a recently developed reusable stainless spatula-type microhook device to incise the trabecular meshwork to Trabectome (Neomeix, Inc) surgery in terms of the 1-year postoperative outcomes of Japanese patients with glaucoma by means of propensity score analyses.Multicenter, retrospective cohort study.We enrolled 553 and 392 patients who underwent Trabectome surgery and μTLO, respectively, between January 2014 and March 2020 at 10 facilities.Logistic regression analysis was conducted to calculate the propensity score, which indicates the likelihood of treatment assignment (Trabectome or μTLO). We set the following factors as outcome-related covariates: age, sex, facility, glaucoma disease types, preoperative intraocular pressure (IOP), glaucoma drug score, mean deviation of Humphrey visual field test results, antithrombotic drug use, the presence or absence of combined cataract surgery, and incision range of the trabecular meshwork (1 or 2 quadrants). We analyzed 4 different methods (matching, inverse probability of treatment weighting [IPTW], stratification, and regression adjustment) using the propensity score. We set 15% as the noninferiority margin based on previous Trabectome meta-analysis results.The primary outcome was surgical success at 1 year after surgery. We defined surgical success as satisfying all 3 criteria: (1) IOP within 5 to 21 mmHg, (2) IOP reduction of 20% or more from preoperative IOP, and (3) no additional glaucoma surgery.The 95% confidence interval of risk difference of surgical failure in μTLO in reference to Trabectome surgery was -12.1% to +9.5% in matching, -12.7% to +11.1% in IPTW, -12.2 to +7.0 in stratification, and -9.7% to +8.1% in regression adjustment, all of which fell within the predetermined noninferiority margin of 15%.Surgical success of μTLO at 1 year after was not inferior to that of Trabectome surgery.
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- 2021
7. Effect of Botulinum Toxin A Treatment on Eyelid Pressure in Eyes with Blepharospasm
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Shiro Mizoue, Koji Namiguchi, Kiyohiko Ohta, and Atsushi Shiraishi
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Male ,Intraocular pressure ,medicine.medical_specialty ,N-group (finite group theory) ,Blepharospasm ,Injections, Intramuscular ,Botulinum toxin a ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,0302 clinical medicine ,Ophthalmology ,Pressure ,medicine ,Humans ,In patient ,Botulinum Toxins, Type A ,Intraocular Pressure ,Dose-Response Relationship, Drug ,business.industry ,Eyelids ,Reproducibility of Results ,Middle Aged ,Botulinum toxin ,eye diseases ,Sensory Systems ,body regions ,Normal volunteers ,Treatment Outcome ,medicine.anatomical_structure ,Neuromuscular Agents ,Oculomotor Muscles ,030221 ophthalmology & optometry ,Female ,sense organs ,Eyelid ,medicine.symptom ,business ,030217 neurology & neurosurgery ,medicine.drug - Abstract
OBJECTIVE To determine the effect of botulinum toxin A (BTX-A) on the eyelid pressure in patients with benign essential blepharospasm (BEB). METHODS Twenty normal volunteers (10 men, 10 women; average age 59.7 ± 11.3 years) and 33 patients (12 men, 21 women; average age 61.1 ± 14.7 years) with BEB were studied. The upper and lower eyelid pressures were measured with a blepharo-tensiometer in the normal subjects (N group). The eyelid pressures and intraocular pressures (IOP) were measured before and after the BTX-A injections in the BEB patients (B group). RESULTS The mean eyelid pressure in the N group was 31.0 ± 6.8 mmHg for the upper eyelid and 29.9 ± 6.5 mmHg for the lower eyelid (P > 0.05). The mean eyelid pressure in the B group before treatment was 35.3 ± 7.0 mmHg for the upper eyelid and 37.8 ± 6.6 mmHg for the lower eyelid. The eyelid pressure in the B group was significantly higher than in the N group for the upper and lower eyelids (both P
- Published
- 2018
8. Changes in Anterior Segment Morphology of Iris Bombe before and after Laser Peripheral Iridotomy in Patients with Uveitic Secondary Glaucoma
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Takashi Suzuki, Atsushi Shiraishi, Shiro Mizoue, Wakako Ikegawa, Yuichi Ohashi, and Koji Namiguchi
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medicine.medical_specialty ,Article Subject ,Scleral spur ,urologic and male genital diseases ,Anterior chamber angle ,03 medical and health sciences ,0302 clinical medicine ,lcsh:Ophthalmology ,Ophthalmology ,Iris bombé ,medicine ,In patient ,cardiovascular diseases ,Iris (anatomy) ,business.industry ,urogenital system ,Secondary glaucoma ,fungi ,medicine.anatomical_structure ,Laser peripheral iridotomy ,lcsh:RE1-994 ,Clinical Study ,030221 ophthalmology & optometry ,business ,030217 neurology & neurosurgery - Abstract
Purpose. To quantify changes in anterior segment (AS) parameters after laser peripheral iridotomy (LPI) using AS-optical coherence tomography (OCT) of iris bombe. Method. AS images of eight eyes were captured before and after iris bombe and more than 2 weeks after LPI (post-LPI) using AS-OCT. We compared the following AS parameters: anterior chamber depth (ACD), anterior chamber volume (ACV), iris curvature (IC), iris thickness at 500 μm from the scleral spur (IT-1) in the middle between the iris root and pupillary margin (IT-2) and 500 μm from the pupillary margin (IT-3) to the anterior chamber angle (ACA) (angle opening distance [AOD750]), and trabecular iris space area. Results. Mean IT-1 and IT-3, but not IT-2, were lower after iris bombe (IT-1, P=0.001; IT-2, P=0.081; and IT-3, P=0.001). There were no significant differences between ACD at pre-LPI and before iris bombe (P=0.096). The mean ACV and AOD750 of iris bombe increased at post-LPI (ACV, P<0.01, and AOD750, P<0.05). The mean IT-1, IT-2, and IT-3 increased at post-LPI (all, P≤0.01). IC decreased at post-LPI (P<0.001), and ACD at post-LPI did not change. Conclusions. The iris extends and becomes thinner during iris bombe. LPI during bombe decreases the IC and increases the ACV and ACA.
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- 2016
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9. Sustainability of Intraocular Pressure Reduction of Travoprost Ophthalmic Solution in Subjects with Normal Tension Glaucoma
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Kazuhisa Miyamoto, Koji Namiguchi, Mikio Nagayama, Shinichi Okuma, Shiro Mizoue, Keiji Yoshikawa, Masaki Tanito, Mineo Ozaki, and Tomoko Naito
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Adult ,Male ,030213 general clinical medicine ,Intraocular pressure ,medicine.medical_specialty ,genetic structures ,Pharmacology toxicology ,03 medical and health sciences ,Tonometry, Ocular ,0302 clinical medicine ,Travoprost Ophthalmic Solution ,Travoprost ,Intraocular pressure (IOP) ,Japan ,Ophthalmology ,Normal tension glaucoma ,medicine ,Humans ,Pharmacology (medical) ,Low Tension Glaucoma ,Antihypertensive Agents ,Intraocular Pressure ,Aged ,Original Research ,Medicine(all) ,Aged, 80 and over ,business.industry ,General Medicine ,Middle Aged ,eye diseases ,Sustainability ,030221 ophthalmology & optometry ,Female ,sense organs ,Ophthalmic Solutions ,business ,IOP-lowering ,medicine.drug - Abstract
Introduction We examined the sustainability of the intraocular pressure (IOP)-lowering efficacy of travoprost (0.004%) ophthalmic solution in subjects with normal tension glaucoma (NTG). Methods Travoprost ophthalmic solution was given once daily at 9 PM to subjects with newly diagnosed NTG or with NTG who had not received any ocular hypotensives within the previous 30 days. IOP was measured at three time points (9 AM, 1 PM, and 5 PM) at baseline and week 12 visits, and at one time point (9 AM) at week 4 and week 8 visits. Conjunctival hyperemia, superficial punctate keratopathy, and other adverse events were evaluated during the observation period. Results Thirty subjects (12 males and 18 females; mean age 65.6 years) from 32 subjects enrolled were included in the efficacy analysis. The mean IOPs (±standard deviation) of 16.6 ± 1.4, 15.7 ± 1.8, and 15.7 ± 2.2 mmHg at 9 AM, 1 PM, and 5 PM, respectively, at baseline reduced significantly to the mean IOPs of 13.0 ± 1.8, 12.7 ± 1.8, and 12.8 ± 1.6 mmHg, respectively, at week 12 (P
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- 2015
10. Comparison of success rates in eye drop instillation between sitting position and supine position
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Yuko Ichikawa, Koji Namiguchi, Takako Miki, Yuzo Umeda, Miyuki Fujiwara, Ryoichi Araki, Atsushi Shiraishi, Tomoko Naito, Yuki Morizane, Shiro Mizoue, Fumio Shiraga, and Keiji Yoshikawa
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Male ,Supine position ,Eye Diseases ,genetic structures ,medicine.medical_treatment ,lcsh:Medicine ,Glaucoma ,Elderly ,0302 clinical medicine ,Medicine and Health Sciences ,Supine Position ,Eye surgery ,lcsh:Science ,Ocular disease ,Aged, 80 and over ,Sitting Position ,Multidisciplinary ,Ophthalmic Procedures ,Age Factors ,Cataract Surgery ,Middle Aged ,University hospital ,Hospitalization ,Retinal Disorders ,Female ,Anatomy ,0305 other medical science ,Research Article ,Adult ,medicine.medical_specialty ,Surgical and Invasive Medical Procedures ,Sitting ,Young Adult ,03 medical and health sciences ,Ocular System ,030502 gerontology ,Ophthalmology ,medicine ,Humans ,Aged ,business.industry ,lcsh:R ,Biology and Life Sciences ,Eye drop ,Cataract surgery ,medicine.disease ,eye diseases ,Geriatrics ,Age Groups ,People and Places ,030221 ophthalmology & optometry ,Eyes ,Population Groupings ,lcsh:Q ,sense organs ,Ophthalmic Solutions ,business ,Head - Abstract
Purpose To compare the success rates of eye drop instillation in the sitting position and supine position among Japanese patients with ocular diseases (cataract, glaucoma, or retinal and vitreous diseases). Methods Patients who were hospitalized in Okayama University Hospital for eye surgery were studied. Instillation procedures of each patient in both the sitting and supine positions were recorded using a video camera at the time of instillation. We defined “success” when one drop fell accurately onto the ocular surface at the first attempt. Instillation of two or more drops, drops delivered to a site other than the eye surface, and touching the eyelashes, eyelids, or conjunctiva with the tip of the eye drop bottle were regarded as “failure”. We excluded patients with vision below counting finger. Results One-hundred and two patients (54 males and 58 females, aged 70.2 ± 12.3 years) with ocular disease who were hospitalized for surgery (cataract: 61.8%, glaucoma: 15.7%, retinal and vitreous diseases: 22.5%) were included in this prospective observational study. The mean duration of eye drop use was 3.1 ± 5.2 years. The success rate of eye drop instillation was significantly higher in the supine position than in the sitting position (64.7% vs. 50%, P = 0.0039). The mean age was significantly higher in the failure group than in the success group (74.0 ± 11.5 vs. 67.7 ± 12.4 years, P = 0.0085) for the sitting position, but not significantly different for the supine position (72.3 ± 12.9 vs. 70.1 ± 12.0 years, P = 0.3849). No significant differences in mean duration of drop use, mean corrected VA, and mean spherical equivalent refraction were observed between success and failure groups, for both sitting and supine positions. Conclusions In the present study, the success rate of eye drop instillation was significantly higher when applied in the supine position than in the sitting position.
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- 2018
11. Factors affecting eye drop instillation in glaucoma patients with visual field defect
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Fumio Shiraga, Kazuhisa Miyamoto, Keiji Yoshikawa, Tomoko Naito, Atushi Shiraishi, Koji Namiguchi, Shiro Mizoue, and Yoichi Kawashima
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Male ,Visual acuity ,Eye Diseases ,genetic structures ,Vision ,medicine.medical_treatment ,Plastic bottle ,Visual Acuity ,lcsh:Medicine ,Social Sciences ,Glaucoma ,Cornea ,boats ,0302 clinical medicine ,Medicine and Health Sciences ,Psychology ,Prospective Studies ,lcsh:Science ,Multidisciplinary ,Middle Aged ,boats.hull_material ,Visual field ,Artificial tears ,medicine.anatomical_structure ,Female ,Sensory Perception ,Anatomy ,medicine.symptom ,Glaucoma, Open-Angle ,Research Article ,medicine.medical_specialty ,Patients ,Open angle glaucoma ,Ocular Anatomy ,Vision Disorders ,03 medical and health sciences ,Ocular System ,Ophthalmology ,medicine ,Humans ,Aged ,business.industry ,lcsh:R ,Biology and Life Sciences ,Eye drop ,medicine.disease ,eye diseases ,Health Care ,030221 ophthalmology & optometry ,Eyes ,lcsh:Q ,sense organs ,Eyelid ,Ophthalmic Solutions ,business ,Head ,030217 neurology & neurosurgery ,Neuroscience - Abstract
Background To investigate the success rate of eye drop instillation in glaucoma patients with visual field defect as well as non-glaucoma volunteers. Factors that may affect the success rate of eye drop instillation were also evaluated. Design A prospective, observational study. Participants Seventy-eight glaucoma patients and 85 non-glaucoma volunteers were recruited in this study. Methods Open angle glaucoma patients with visual field defect as well as non-glaucoma volunteers were asked to video record their procedures of eye drop instillation using a 5-mL plastic bottle of artificial tear solution. Success of eye drop instillation was judged on video based on the first one drop of solution successfully applied on the cornea, by two investigators. Main outcome measures Success rate of eye drop instillation in glaucoma patients and non-glaucoma volunteers. Factors related to success rate of eye drop instillation, such as visual field defect and clinical characteristics, were also analyzed using multivariable logistic regression. Results No significant deference in mean age was observed between two groups (glaucoma: 64.5 ± 14.4 years, non-glaucoma: 60.9 ± 14.1 years, P = 0.1156). Success rate of eye drop instillation was significantly lower (P = 0.0215) in glaucoma patients (30/78; 38.5%) than in non-glaucoma volunteers (48/85; 56.5%). The most frequent reason of instillation failure in glaucoma patients was touching the bulbar conjunctiva, cornea, eyelid or eyelashes with the tip of the bottle (29.5%). Multivariable logistic regression analysis identified lower corrected visual acuity (VA) (≤ 1.0; odds ratio [OR] = 0.20, 95% confidence interval [CI] 0.04–0.93, P = 0.0411), lower mean deviation (MD) (< -12 dB; OR = 0.20, 95% CI 0.05–0.86, P = 0.0307) and visual field defect (VFD) in the inferior hemifield (OR = 0.11, 95% CI 0.02–0.34, P < 0.001) to be significantly related to instillation failure in glaucoma patients. Conclusions Success rate of eye drop instillation was significantly lower in glaucoma patients than in non-glaucoma volunteers. Corrected VA ≤ 1.0, MD < -12 dB and/or VFD in the inferior hemifield may be related to failure of eye drop instillation.
- Published
- 2017
12. Anterior Segment Optical Coherence Tomography Analysis of Clinically Unilateral Pseudoexfoliation Syndrome: Evidence of Bilateral Involvement and Morphologic Factors Related to Asymmetry
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Hiroshi Sakai, Xiaodong Zheng, Shoichi Sawaguchi, Shiro Mizoue, Koji Namiguchi, Tomoko Goto, Atsushi Shiraishi, and Yuichi Ohashi
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Male ,medicine.medical_specialty ,genetic structures ,Anterior Chamber ,Pseudoexfoliation syndrome ,Iris ,Exfoliation Syndrome ,Anterior chamber angle ,Pupil ,Optical coherence tomography ,Ophthalmology ,medicine ,Humans ,In patient ,Iris (anatomy) ,Normal control ,Lighting ,Aged ,Aged, 80 and over ,medicine.diagnostic_test ,business.industry ,Pseudoexfoliation ,Reproducibility of Results ,Darkness ,Middle Aged ,medicine.disease ,eye diseases ,Extracellular Matrix ,medicine.anatomical_structure ,Female ,sense organs ,business ,Sclera ,Tomography, Optical Coherence - Abstract
PURPOSE. To compare the morphology of the anterior chamber angle (ACA) and iris in eyes with pseudoexfoliation (PEX) syndrome to that of their clinically unaffected fellow eyes and normal control eyes. METHODS. Forty-two patients with unilateral PEX syndrome and 42 normal subjects were studied. Eyes were separated into those with PEX, their clinically unaffected fellow eyes, and normal eyes. The dark-light changes of the ACA and iris were documented by anterior segment optical coherence tomography (AS-OCT) video recordings. The nasal ACA parameters including the angle opening distance at 500 m (AOD500), the trabecular-iris space at 500 m (TISA500), and the trabeculariris angle at 500 m (TIA500); anterior chamber depth (ACD); iris-lens contact distance (ILCD), and iris configuration were analyzed with the built-in software and a customized program. RESULTS. The ACA parameters were not significantly different among all three groups in the dark. The PEX eyes had significantly smaller ACA parameters than their fellow eyes and normal control eyes in the light. PEX eyes also had significantly shallower ACD, longer ILCD, and greater iris convexity (both in dark and light), and thinner iris (in dark) than their fellow eyes. The fellow eyes had significantly lower ACD both in the dark and light, and smaller angle opening distance at 500 m and ILCD in the light than normal controls. There were no significant differences in the iris area among the three groups. CONCLUSIONS. Differences in the anterior segmental morphology are present between PEX and fellow eyes. These disparities may be related to the asymmetry in patients with the unilateral PEX syndrome. (Invest Ophthalmol Vis Sci. 2011;52:5679‐5684)
- Published
- 2011
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