1. Impact of a new liver immune status index among patients with hepatocellular carcinoma after initial hepatectomy
- Author
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Yuki Imaoka, Masahiro Ohira, Ichiya Chogahara, Tomoaki Bekki, Kouki Imaoka, Koki Sato, Marlen Doskali, Ryosuke Nakano, Takuya Yano, Fumihiro Hirata, Shintaro Kuroda, Hiroyuki Tahara, Kentaro Ide, Kohei Ishiyama, Tsuyoshi Kobayashi, Yuka Tanaka, and Hideki Ohdan
- Subjects
anti‐tumor activity ,hepatectomy ,hepatocellular carcinoma ,natural killer cells ,Surgery ,RD1-811 ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Abstract Aim The anti‐tumor effects of natural killer (NK) cells vary among individuals. Tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL) expressed on liver NK cells is a marker of anti‐tumor cytotoxicity against hepatocellular carcinoma (HCC) in immune cell therapy. This study aimed to develop a liver immune status index (LISI) that predicts low TRAIL expression and validates its ability to predict recurrence after initial hepatectomy for primary HCC. Methods A functional analysis of liver NK cells co‐cultured with interleukin‐2 for 3 days was performed of 40 liver transplant donors. The LISI, which predicted low TRAIL expression (25% quartile:
- Published
- 2023
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