20 results on '"Koliva M"'
Search Results
2. Haplotype-based analysis of common variation in the acetyl-CoA carboxylase α gene and breast cancer risk: A case-control study nested within the European Prospective Investigation into Cancer and Nutrition
- Author
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Sinilnikova, O.M. McKay, J.D. Tavtigian, S.V. Canzian, F. DeSilva, D. Biessy, C. Monnier, S. Dossus, L. Boillot, C. Gioia, L. Hughes, D.J. Jensen, M.K. Overvad, K. Tjonneland, A. Olsen, A. Clavel-Chapelon, F. Chajès, V. Joulin, V. Linseisen, J. Chang-Claude, J. Boeing, H. Dahm, S. Trichopoulou, A. Trichopoulos, D. Koliva, M. Khaw, K.-T. Bingham, S. Allen, N.E. Key, T. Palli, D. Panico, S. Berrino, F. Tumino, R. Vineis, P. Bueno-de-Mesquita, H.B. Peeters, P.H. Van Gils, C.H. Lund, E. Pera, G. Quirós, J.R. Dorronsoro, M. García, C.M. Tormo, M.-J. Ardanaz, E. Hallmans, G. Lenner, P. Berglund, G. Manjer, J. Riboli, E. Lenoir, G.M. Kaaks, R. more...
- Abstract
A key fatty acid synthesis enzyme, acetyl-CoA carboxylase α. (ACC-α), has been shown to be highly expressed in human breast cancer and other tumor types and also to specifically interact with the protein coded by one of two major breast cancer susceptibility genes BRCA1. We used a comprehensive haplotype analysis to examine the contribution of the ACC-α common genetic variation (allele frequency >5%) to breast cancer in a case-control study (1,588 cases/2,600 controls) nested within the European Prospective Investigation into Cancer and Nutrition. We identified 21 haplotype-tagging polymorphisms efficiently capturing common variation within 325 kb of ACC-α and surrounding sequences using genotype data from the HapMap project and our resequencing data. We found an effect on overall risk of breast cancer in homozygous carriers of one common haplotype [odds ratio (OR), 1.74; 95% confidence interval (95% CI), 1.03-2.94]. When the data were subdivided by menopausal status, we found statistical evidence of heterogeneity for two other common haplotypes (P value for heterogeneity = 0.016 and 0.045). In premenopausal women, the carriers of these haplotypes, compared with noncarriers, had an altered risk of breast cancer (OR, 0.70; 95% CI, 0.53-0.92 and OR, 1.35; 95% CI, 1.04-1.76). These findings were not significant after adjustment for multiple testing and therefore should be considered as preliminary and evaluated in larger independent studies. However, they suggest a possible role of the ACC-α common sequence variants in susceptibility to breast cancer and encourage studies of other genes involved in fatty acid synthesis. Copyright © 2007 American Association for Cancer Research. more...
- Published
- 2007
Catalog
3. IGF-1, IGFBP-3 and breast cancer risk in women: The European Prospective Investigation into Cancer and Nutrition (EPIC)
- Author
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Rinaldi, S. Peeters, P. H. M. Berrino, F. Dossus, L. and Biessy, C. Olsen, A. Tjonneland, A. Overvad, K. and Clavel-Chapelon, F. Boutron-Ruault, M. C. Tehard, B. Nagel, G. Linseisen, J. Boeing, H. Lahmann, P. H. Trichopoulou, A. Trichopoulos, D. Koliva, M. Palli, D. Panico, S. and Tumino, R. Sacerdote, C. van Gils, C. H. van Noord, P. and Grobbee, D. E. Bueno-de-Mesquita, H. B. Gonzalez, C. A. and Agudo, A. Chirlaque, M. D. Barricarte, A. Larranaga, N. and Quiros, J. R. Bingham, S. Khaw, K. T. Key, T. Allen, N. E. Lukanova, A. Slimani, N. Saracci, R. Riboli, E. and Kaaks, R. more...
- Abstract
Blood concentrations of insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3) have recently been associated with breast cancer risk, notably in women who developed breast cancer at a young age. Prospective studies published so far, however, were relatively small and odds ratio (OR) estimates imprecise. We present the results of a large prospective case-control study nested within the European Prospective Investigation into Cancer and Nutrition on total IGIF-I, IGFBP-3 and breast cancer risk including 1081 incident cases of invasive breast cancer and 2098 matched control subjects. Increasing IGF-I and IGFBP-3 concentrations were associated with a significant increase in breast cancer risk in women who developed breast cancer after 50 years of age (highest vs lowest quintile OR 1.38 (95% confidence interval (CI) 1.02-1.86), P = 0.01, and 1.44 (95% CI 1.04-1.98), P = 0.01, respectively), but no relationship was observed in younger women (OR = 1.03 (95% CI 0.60-1.77), P = 0.81 for IGF-I, and OR = 0.92 (95% CI 0.50-1.70), P = 0.69 for IGFBP-3). There was, however, significant heterogeneity in the relationship of breast cancer with serum IGF-I and IGFBP-3 levels depending on the time interval between blood donation and tumor diagnosis. A reduction in breast cancer risk with increasing IGF-I concentrations was observed in cases with a diagnosis of cancer less than 2 years after blood donation, (OR = 0.76 (95% CI 0.57-1.03)), while an increase in risk was observed for women with a later diagnosis (above or equal to two years after blood collection, OR = 1.51 (95% CI 1.19-1.91)). A similar pattern was observed for IGFBP-3. This study confirms previous findings for an association of serum IGF-I and IGFBP-3 concentrations with breast cancer risk, particularly for women with a later diagnosis of cancer, but it does not support the hypothesis of an involvement of IGF-I in younger women. more...
- Published
- 2006
4. Relationship of alcohol intake and sex steroid concentrations in blood in pre- and post-menopausal women: The European Prospective Investigation into Cancer and Nutrition
- Author
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Rinaldi, S. Peeters, P.H.M. Bezemer, I.D. Dossus, L. Biessy, C. Sacerdote, C. Berrino, F. Panico, S. Palli, D. Tumino, R. Khaw, K.T. Bingham, S. Allen, N.E. Key, T. Jensen, M.K. Overvad, K. Olsen, A. Tjonneland, A. Amiano, P. Ardanaz, E. Agudo, A. Martinez-García, C. Quirós, J.R. Tormo, M.J. Nagel, G. Linseisen, J. Boeing, H. Schulz, M. Grobbee, D.E. Bueno-De-Mesquita, H.B. Koliva, M. Kyriazi, G. Thrichopoulou, A. Boutron-Ruault, M.C. Clavel-Chapelon, F. Ferrari, P. Slimani, N. Saracci, R. Riboli, E. Kaaks, R. more...
- Abstract
Objective: Women with a moderate intake of alcohol have higher concentrations of sex steroids in serum, and higher risk of developing breast cancer, compared to non-drinkers. In the present study, we investigate the relationships between alcohol consumption and serum levels of sex steroids and sex-hormone binding globulin (SHBG) in 790 pre- and 1,291 post-menopausal women, who were part of the European Prospective Investigation into Cancer and Nutrition (EPIC). Methods: Serum levels of testosterone (T), androstenedione (Δ4), dehydroepiandrosterone sulphate (DHEAS), estrone (E 1), estradiol (E2) and SHBG were measured by direct immunoassays. Free T (fT) and free E2 (fE2) were calculated according to mass action laws. Current alcohol intake exposure to alcohol was assessed from dietary questionnaires. Results: Pre-menopausal women who consumed more than 25 g/day of alcohol had about 30% higher DHEAS, T and fT, 20% higher Δ4 and about 40% higher E1, concentrations compared to women who were non-consumers. E2, fE 2 and SHBG concentrations showed no association with current alcohol intake. In post-menopausal women, DHEAS, fT, T, Δ4, and E 1 concentrations were between 10% and 20% higher in women who consumed more than 25 g/day of alcohol compared to non-consumers. E2 or fE2 were not associated with alcohol intake at all. SHBG levels were about 15% lower in alcohol consumers compared to non-consumers. Conclusion: This study supports the hypothesis of an influence of alcohol intake on sex hormone concentrations in blood. © Springer Science+Business Media B.V. 2006. more...
- Published
- 2006
5. Physical activity and lung cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort
- Author
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Steindorf, K. Friedenreich, C. Linseisen, J. Rohrmann, S. Rundle, A. Veglia, F. Vineis, P. Johnsen, N.F. Tjønneland, A. Overvad, K. Raaschou-Nielsen, O. Clavel-Chapelon, F. Boutron-Ruault, M.-C. Schulz, M. Boeing, H. Trichopoulou, A. Kalapothaki, V. Koliva, M. Krogh, V. Palli, D. Tumino, R. Panico, S. Monninkhof, E. Peeters, P.H. Boshuizen, H.C. Bueno-De-Mesquita, H.B. Chirlaque, M.-D. Agudo, A. Larrañaga, N. Quirós, J.R. Martínez, C. Barricarte, A. Janzon, L. Berglund, G. Bingham, S. Khaw, K.-T. Key, T.J. Norat, T. Jenab, M. Cust, A. Riboli, E. more...
- Abstract
Research conducted predominantly in male populations on physical activity and lung cancer has yielded inconsistent results. We examined this relationship among 416,277 men and women from the European Prospective Investigation into Cancer and Nutrition (EPIC). Detailed information on recent recreational, household and occupational physical activity, smoking habits and diet was assessed at baseline between 1992 and 2000. Relative risks (RR) were estimated using Cox regression. During 6.3 years of follow-up we identified 607 men and 476 women with incident lung cancer. We did not observe an inverse association between recent occupational, recreational or household physical activity and lung cancer risk in either males or females. However, we found some reduction in lung cancer risk associated with sports in males (adjusted RR = 0.71; 95% confidence interval 0.50-0.98; highest tertile vs. inactive group), cycling (RR = 0.73; 0.54-0.99) in females and non-occupational vigorous physical activity. For occupational physical activity, lung cancer risk was increased for unemployed men (adjusted RR = 1.57; 1.20-2.05) and men with standing occupations (RR = 1.35; 1.02-1.79) compared with sitting professions. There was no evidence of heterogeneity of physical activity associations across countries, or across any of the considered cofactors. For some histologic subtypes suggestive sex-specific reductions, limited by subgroup sizes, were observed, especially with vigorous physical activity. In total, our study shows no consistent protective associations of physical activity with lung cancer risk. It can be assumed that the elevated risks found for occupational physical activity are not produced mechanistically by physical activity itself but rather reflect exposure to occupation-related lung cancer risk factors. © 2006 Wiley-Liss, Inc. more...
- Published
- 2006
6. Consumption of vegetables and fruits and risk of breast cancer
- Author
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van Gils, CH Peeters, PHT Bueno-De-Mesquita, HB Boshuizen, HC Lahmann, PH Clavel-Chapelon, F Thiebaut, A Kesse, E and Sieri, S Palli, D Tumino, R Panico, S Vineis, P and Gonzalez, CA Ardanaz, E Sanchez, MJ Amiano, P Navarro, C and Quiros, JR Key, TJ Allen, N Khaw, KT Bingham, SA and Psaltopoulou, T Koliva, M Trichopoulou, A Nagel, G and Linseisen, J Boeing, H Berglund, G Wirfalt, E Hallmans, G Lenner, P Overvad, K Tjonneland, A Olsen, A Lund, E Engeset, D Alsaker, E Norat, TA Kaaks, R Slimani, N Riboli, E more...
- Abstract
Context The intake of vegetables and fruits has been thought to protect against breast cancer. Most of the evidence comes from case-control studies, but a recent pooled analysis of the relatively few published cohort studies suggests no significantly reduced breast cancer risk is associated with vegetable and fruit consumption. Objective To examine the relation between total and specific vegetable and fruit intake and the incidence of breast cancer. Design, Setting, and Participants Prospective study of 285526 women between the ages of 25 and 70 years, participating in the European Prospective Investigation Into Cancer and Nutrition (EPIC) study, recruited from 8 of the 10 participating European countries. Participants completed a dietary questionnaire in 1992-1998 and were followed up for incidence of cancer until 2002. Main Outcome Measures Relative risks for breast cancer by total and specific vegetable and fruit intake. Analyses were stratified by age at recruitment and study center. Relative risks were adjusted for established breast cancer risk factors. Results During 1486402 person-years (median duration of follow-up, 5.4 years), 3659 invasive incident breast cancer cases were reported. No significant associations between vegetable or fruit intake and breast cancer risk were observed. Relative risks for the highest vs the lowest quintile were 0.98 (95% confidence interval [CI], 0.84-1.14) for total vegetables, 1.09 (95% Cl, 0.94-1.25) for total fruit, and 1.05 (95% Cl, 0.92-1.20) for fruit and vegetable juices. For 6 specific vegetable subgroups no associations with breast cancer risk were observed either. Conclusion Although the period of follow-up is limited for now, the results suggest that total or specific vegetable and fruit intake is not associated with risk for breast cancer. more...
- Published
- 2005
7. IGF-I, IGFBP-3 and breast cancer risk in women: The European Prospective Investigation into Cancer and Nutrition (EPIC).
- Author
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Rinaldi, S., Peeters, P.H.M., Berrino, F., Dossus, L., Biessy, C., Olsen, A., Tjonneland, A., Overvad, K., Clavel-Chapelon, F., Boutron-Ruault, M.C., Tehard, B., Nagel, G., Linseisen, J., Boeing, H.H., Lahmann, P.H., Trichopoulou, A., Trichopoulos, D., Koliva, M., Palli, D., Panico, S., Tumino, R., Sacerdote, C., van Gils, C.H., van Noord, P.A.H., Grobbee, D.E., Bueno de Mesquita, H.B., Gonzalez, C.A., Agudo, A, Chirlaque, M.D., Barricarte, A., Larranaga, N., Quiros, J.R., Bingham, S, Khaw, K.T., Key, T.J., Allen, N.E., Lukanova, A., Slimani, N., Saracci, R., Riboli, E., Kaaks, R., Rinaldi, S., Peeters, P.H.M., Berrino, F., Dossus, L., Biessy, C., Olsen, A., Tjonneland, A., Overvad, K., Clavel-Chapelon, F., Boutron-Ruault, M.C., Tehard, B., Nagel, G., Linseisen, J., Boeing, H.H., Lahmann, P.H., Trichopoulou, A., Trichopoulos, D., Koliva, M., Palli, D., Panico, S., Tumino, R., Sacerdote, C., van Gils, C.H., van Noord, P.A.H., Grobbee, D.E., Bueno de Mesquita, H.B., Gonzalez, C.A., Agudo, A, Chirlaque, M.D., Barricarte, A., Larranaga, N., Quiros, J.R., Bingham, S, Khaw, K.T., Key, T.J., Allen, N.E., Lukanova, A., Slimani, N., Saracci, R., Riboli, E., and Kaaks, R. more...
- Published
- 2006
8. IGF-I, IGFBP-3 and breast cancer risk in women: The European Prospective Investigation into Cancer and Nutrition (EPIC).
- Author
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JC onderzoeksprogramma Kanker, Epidemiology & Health Economics, Rinaldi, S., Peeters, P.H.M., Berrino, F., Dossus, L., Biessy, C., Olsen, A., Tjonneland, A., Overvad, K., Clavel-Chapelon, F., Boutron-Ruault, M.C., Tehard, B., Nagel, G., Linseisen, J., Boeing, H.H., Lahmann, P.H., Trichopoulou, A., Trichopoulos, D., Koliva, M., Palli, D., Panico, S., Tumino, R., Sacerdote, C., van Gils, C.H., van Noord, P.A.H., Grobbee, D.E., Bueno de Mesquita, H.B., Gonzalez, C.A., Agudo, A, Chirlaque, M.D., Barricarte, A., Larranaga, N., Quiros, J.R., Bingham, S, Khaw, K.T., Key, T.J., Allen, N.E., Lukanova, A., Slimani, N., Saracci, R., Riboli, E., Kaaks, R., JC onderzoeksprogramma Kanker, Epidemiology & Health Economics, Rinaldi, S., Peeters, P.H.M., Berrino, F., Dossus, L., Biessy, C., Olsen, A., Tjonneland, A., Overvad, K., Clavel-Chapelon, F., Boutron-Ruault, M.C., Tehard, B., Nagel, G., Linseisen, J., Boeing, H.H., Lahmann, P.H., Trichopoulou, A., Trichopoulos, D., Koliva, M., Palli, D., Panico, S., Tumino, R., Sacerdote, C., van Gils, C.H., van Noord, P.A.H., Grobbee, D.E., Bueno de Mesquita, H.B., Gonzalez, C.A., Agudo, A, Chirlaque, M.D., Barricarte, A., Larranaga, N., Quiros, J.R., Bingham, S, Khaw, K.T., Key, T.J., Allen, N.E., Lukanova, A., Slimani, N., Saracci, R., Riboli, E., and Kaaks, R. more...
- Published
- 2006
9. Consumption of vegetables and fruits and risk of breast cancer.
- Author
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van Gils, C.H., Peeters, P.H.M., Bueno de Mesquita, H.B., Boshuizen, H.C., Lahmann, P.H., Clavel-Chapelon, F., Thiebaut, A., Kesse, E., Sieri, S., Palli, D., Tumino, R., Panico, S., Vineis, P., Gonzalez, C.A., Ardanaz, E., Sanchez, M.J., Amiano, P., Navarro, C., Quiros, J.R., Key, T.J., Allen, N., Khaw, K.T., Bingham, S, Psaltopoulou, T., Koliva, M., Trichopoulou, A., Nagel, G., Linseisen, J., Boeing, H.H., Berglund, G., Wirfalt, E., Hallmans, G., Lenner, P., Overvad, K., Tjonneland, A., Olsen, A., Lund, E., Engeset, D., Alsaker, E., Norat, T., Kaaks, R., Slimani, N., Riboli, E., van Gils, C.H., Peeters, P.H.M., Bueno de Mesquita, H.B., Boshuizen, H.C., Lahmann, P.H., Clavel-Chapelon, F., Thiebaut, A., Kesse, E., Sieri, S., Palli, D., Tumino, R., Panico, S., Vineis, P., Gonzalez, C.A., Ardanaz, E., Sanchez, M.J., Amiano, P., Navarro, C., Quiros, J.R., Key, T.J., Allen, N., Khaw, K.T., Bingham, S, Psaltopoulou, T., Koliva, M., Trichopoulou, A., Nagel, G., Linseisen, J., Boeing, H.H., Berglund, G., Wirfalt, E., Hallmans, G., Lenner, P., Overvad, K., Tjonneland, A., Olsen, A., Lund, E., Engeset, D., Alsaker, E., Norat, T., Kaaks, R., Slimani, N., and Riboli, E. more...
- Published
- 2005
10. Consumption of vegetables and fruits and risk of breast cancer.
- Author
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JC onderzoeksprogramma Kanker, Epidemiology & Health Economics, van Gils, C.H., Peeters, P.H.M., Bueno de Mesquita, H.B., Boshuizen, H.C., Lahmann, P.H., Clavel-Chapelon, F., Thiebaut, A., Kesse, E., Sieri, S., Palli, D., Tumino, R., Panico, S., Vineis, P., Gonzalez, C.A., Ardanaz, E., Sanchez, M.J., Amiano, P., Navarro, C., Quiros, J.R., Key, T.J., Allen, N., Khaw, K.T., Bingham, S, Psaltopoulou, T., Koliva, M., Trichopoulou, A., Nagel, G., Linseisen, J., Boeing, H.H., Berglund, G., Wirfalt, E., Hallmans, G., Lenner, P., Overvad, K., Tjonneland, A., Olsen, A., Lund, E., Engeset, D., Alsaker, E., Norat, T., Kaaks, R., Slimani, N., Riboli, E., JC onderzoeksprogramma Kanker, Epidemiology & Health Economics, van Gils, C.H., Peeters, P.H.M., Bueno de Mesquita, H.B., Boshuizen, H.C., Lahmann, P.H., Clavel-Chapelon, F., Thiebaut, A., Kesse, E., Sieri, S., Palli, D., Tumino, R., Panico, S., Vineis, P., Gonzalez, C.A., Ardanaz, E., Sanchez, M.J., Amiano, P., Navarro, C., Quiros, J.R., Key, T.J., Allen, N., Khaw, K.T., Bingham, S, Psaltopoulou, T., Koliva, M., Trichopoulou, A., Nagel, G., Linseisen, J., Boeing, H.H., Berglund, G., Wirfalt, E., Hallmans, G., Lenner, P., Overvad, K., Tjonneland, A., Olsen, A., Lund, E., Engeset, D., Alsaker, E., Norat, T., Kaaks, R., Slimani, N., and Riboli, E. more...
- Published
- 2005
11. IGF-I, IGFBP-3 and breast cancer risk in women: The European Prospective Investigation into Cancer and Nutrition (EPIC)
- Author
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Rinaldi, S, primary, Peeters, P H M, additional, Berrino, F, additional, Dossus, L, additional, Biessy, C, additional, Olsen, A, additional, Tjonneland, A, additional, Overvad, K, additional, Clavel-Chapelon, F, additional, Boutron-Ruault, M C, additional, Téhard, B, additional, Nagel, G, additional, Linseisen, J, additional, Boeing, H, additional, Lahmann, P H, additional, Trichopoulou, A, additional, Trichopoulos, D, additional, Koliva, M, additional, Palli, D, additional, Panico, S, additional, Tumino, R, additional, Sacerdote, C, additional, van Gils, C H, additional, van Noord, P, additional, Grobbee, D E, additional, Bueno-de-Mesquita, H B, additional, Gonzalez, C A, additional, Agudo, A, additional, Chirlaque, M D, additional, Barricarte, A, additional, Larrañaga, N, additional, Quiros, J R, additional, Bingham, S, additional, Khaw, K T, additional, Key, T, additional, Allen, N E, additional, Lukanova, A, additional, Slimani, N, additional, Saracci, R, additional, Riboli, E, additional, and Kaaks, R, additional more...
- Published
- 2006
- Full Text
- View/download PDF
12. Physical activity and lung cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
- Author
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Steindorf, K., Friedenreich, C., Linseisen, J., Rohrmann, S., Rundle, A., Veglia, F., Vineis, P., Nf, Johnsen, Anne Tjønneland, Kim Overvad, Raaschou-Nielsen, O., Clavel-Chapelon, F., M-C, Boutron-Ruault, Schulz, M., Boeing, H., Trichopoulou, A., Kalapothaki, V., Koliva, M., Krogh, V., Palli, D., Tumino, R., Panico, S., Monninkhof, E., Ph, Peeters, Hc, Boshuizen, Hb, Bueno-De-Mesquita, M-D, Chirlaque, Agudo, A., Larranaga, N., Jr, Quirós, Martinez, C., Barricarte, A., Janzon, L., Berglund, G., Bingham, S., K-T, Khaw, Tj, Key, Norat, T., Jenab, M., Cust, A., and Riboli, E. more...
13. Physical activity and lung cancer risk in the European Prospective Investigation into Cancer and Nutrition Cohort
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Andrew Rundle, Kim Overvad, H. Bas Bueno-de-Mesquita, N. F. Johnsen, Mandy Schulz, Petra H.M. Peeters, Jakob Linseisen, Christine M. Friedenreich, Anne E. Cust, Carmen Martinez, María Dolores Chirlaque, Teresa Norat, Evelyn M. Monninkhof, Karen Steindorf, Anne Tjønneland, Hendriek C. Boshuizen, Françoise Clavel-Chapelon, Ole Raaschou-Nielsen, Sheila Bingham, Antonia Trichopoulou, Lars Janzon, Maria Koliva, José Ramón Quirós, Timothy J. Key, Nerea Larrañaga, Antonio Agudo, Domenico Palli, Sabine Rohrmann, Vittorio Krogh, Aurelio Barricarte, Elio Riboli, Victoria Kalapothaki, Mazda Jenab, Kay-Tee Khaw, Salvatore Panico, Marie-Christine Boutron-Ruault, Göran Berglund, Heiner Boeing, Fabrizio Veglia, Paolo Vineis, Rosario Tumino, Steindorf, K, Friedenreich, C, Linseisen, J, Rohrmann, S, Rundle, A, Veglia, F, Vineis, P, Johnsen, Nf, Tjonneland, A, Overvad, K, RAASCHOU NIELSEN, O, CLAVEL CHAPELON, F, BOUTRON RUAULT, Mc, Schulz, M, Boeing, H, Trichopoulou, A, Kalapothaki, V, Koliva, M, Krogh, V, Palli, D, Tumino, R, Panico, Salvatore, Monninkhof, E, Peeters, Ph, Boshuizen, Hc, BUENO DE MESQUITA, Hb, Chirlaque, Md, Agudo, A, Larranaga, N, Quiros, Jr, Martinez, C, Barricarte, A, Janzon, L, Berglund, G, Bingham, S, Khaw, Kt, Key, Tj, Norat, T, Jenab, M, Cust, A, and Riboli, E. more...
- Subjects
Adult ,Male ,Cancer Research ,medicine.medical_specialty ,Lung Neoplasms ,Physical exercise ,Motor Activity ,Risk Assessment ,Risk Factors ,Occupational Exposure ,Odds Ratio ,Medicine ,Humans ,Nutritional Physiological Phenomena ,Prospective Studies ,ddc:610 ,Risk factor ,Sex Distribution ,Prospective cohort study ,Lung cancer ,Aged ,Proportional Hazards Models ,business.industry ,Odds ratio ,Middle Aged ,medicine.disease ,European Prospective Investigation into Cancer and Nutrition ,Europe ,Oncology ,Relative risk ,Physical therapy ,Recreation ,Female ,business ,Demography ,Cohort study - Abstract
Research conducted predominantly in male populations on physical activity and lung cancer has yielded inconsistent results. We examined this relationship among 416,277 men and women from the European Prospective Investigation into Cancer and Nutrition (EPIC). Detailed information on recent recreational, household and occupational physical activity, smoking habits and diet was assessed at baseline between 1992 and 2000. Relative risks (RR) were estimated using Cox regression. During 6.3 years of follow-up we identified 607 men and 476 women with incident lung cancer. We did not observe an inverse association between recent occupational, recreational or household physical activity and lung cancer risk in either males or females. However, we found some reduction in lung cancer risk associated with sports in males (adjusted RR = 0.71; 95% confidence interval 0.50-0.98; highest tertile vs. inactive group), cycling (RR = 0.73; 0.54-0.99) in females and non-occupational vigorous physical activity. For occupational physical activity, lung cancer risk was increased for unemployed men (adjusted RR = 1.57; 1.20-2.05) and men with standing occupations (RR = 1.35; 1.02-1.79) compared with sitting professions. There was no evidence of heterogeneity of physical activity associations across countries, or across any of the considered cofactors. For some histologic subtypes suggestive sex-specific reductions, limited by subgroup sizes, were observed, especially with vigorous physical activity. In total, our study shows no consistent protective associations of physical activity with lung cancer risk. It can be assumed that the elevated risks found for occupational physical activity are not produced mechanistically by physical activity itself but rather reflect exposure to occupation-related lung cancer risk factors. more...
- Published
- 2016
- Full Text
- View/download PDF
14. Haplotype-based analysis of common variation in the acetyl-coA carboxylase alpha gene and breast cancer risk: a case-control study nested within the European Prospective Investigation into Cancer and Nutrition
- Author
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Eva Ardanaz, James McKay, Guillem Pera, Véronique Chajès, Carla H. van Gils, Miren Dorronsoro, H. Bas Bueno-de-Mesquita, Rudolf Kaaks, Federico Canzian, Petra H.M. Peeters, Göran Berglund, Lydie Gioia, Sean V. Tavtigian, Heiner Boeing, Göran Hallmans, Carine Biessy, Carmen Martinez Garcia, Anja Olsen, Sheila Bingham, Antonia Trichopoulou, Olga M. Sinilnikova, Eiliv Lund, Naomi E. Allen, Franco Berrino, Per Lenner, Françoise Clavel-Chapelon, Stephan Dahm, Majken K. Jensen, Jakob Linseisen, Deepika DeSilva, Elio Riboli, José Ramón Quirós, Jonas Manjer, Kim Overvad, Anne Tjønneland, Laure Dossus, Dimitrios Trichopoulos, Rosario Tumino, Virginie Joulin, Paolo Vineis, Kay-Tee Khaw, Salvatore Panico, Gilbert M. Lenoir, Domenico Palli, Stéphanie Monnier, Jenny Chang-Claude, María José Tormo, Maria Koliva, David J. Hughes, Catherine Boillot, Timothy J. Key, Sinilnikova, Om, Mckay, Jd, Tavtigian, Sv, Canzian, F, Desilva, D, Biessy, C, Monnier, S, Dossus, L, Boillot, C, Gioia, L, Hughes, Dj, Jensen, Mk, Overvad, K, Tjonneland, A, Olsen, A, CLAVEL CHAPELON, F, Chajes, V, Joulin, V, Linseisen, J, CHANG CLAUDE, J, Boeing, H, Dahm, S, Trichopoulou, A, Trichopoulos, D, Koliva, M, Khaw, Kt, Bingham, S, Allen, Ne, Key, T, Palli, D, Panico, Salvatore, Berrino, F, Tumino, R, Vineis, P, BUENO DE MESQUITA, Hb, Peeters, Ph, VAN GILS, Ch, Lund, E, Pera, G, Quiros, Jr, Dorronsoro, M, MARTINEZ GARCIA, C, Tormo, Mj, Ardanaz, E, Hallmans, G, Lenner, P, Berglund, G, Manjer, J, Riboli, E, Lenoir, Gm, and Kaaks, R. more...
- Subjects
Oncology ,Adult ,medicine.medical_specialty ,Genotype ,Epidemiology ,Breast Neoplasms ,Biology ,Breast cancer ,Gene Frequency ,Polymorphism (computer science) ,Risk Factors ,Internal medicine ,medicine ,Humans ,Genetic Predisposition to Disease ,Risk factor ,Alleles ,Aged ,Genetics ,Chi-Square Distribution ,Haplotype ,Acetyl-CoA carboxylase ,Case-control study ,Genetic Variation ,Middle Aged ,medicine.disease ,European Prospective Investigation into Cancer and Nutrition ,Europe ,Logistic Models ,Haplotypes ,Case-Control Studies ,Female ,Acetyl-CoA Carboxylase - Abstract
A key fatty acid synthesis enzyme, acetyl-CoA carboxylase α (ACC-α), has been shown to be highly expressed in human breast cancer and other tumor types and also to specifically interact with the protein coded by one of two major breast cancer susceptibility genes BRCA1. We used a comprehensive haplotype analysis to examine the contribution of the ACC-α common genetic variation (allele frequency >5%) to breast cancer in a case-control study (1,588 cases/2,600 controls) nested within the European Prospective Investigation into Cancer and Nutrition. We identified 21 haplotype-tagging polymorphisms efficiently capturing common variation within 325 kb of ACC-α and surrounding sequences using genotype data from the HapMap project and our resequencing data. We found an effect on overall risk of breast cancer in homozygous carriers of one common haplotype [odds ratio (OR), 1.74; 95% confidence interval (95% CI), 1.03-2.94]. When the data were subdivided by menopausal status, we found statistical evidence of heterogeneity for two other common haplotypes (P value for heterogeneity = 0.016 and 0.045). In premenopausal women, the carriers of these haplotypes, compared with noncarriers, had an altered risk of breast cancer (OR, 0.70; 95% CI, 0.53-0.92 and OR, 1.35; 95% CI, 1.04-1.76). These findings were not significant after adjustment for multiple testing and therefore should be considered as preliminary and evaluated in larger independent studies. However, they suggest a possible role of the ACC-α common sequence variants in susceptibility to breast cancer and encourage studies of other genes involved in fatty acid synthesis. (Cancer Epidemiol Biomarkers Prev 2007;16(3):409–15) more...
- Published
- 2007
15. Relationship of alcohol intake and sex steroid concentrations in blood in pre- and post-menopausal women: the European Prospective Investigation into Cancer and Nutrition
- Author
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Antonio Agudo, Elio Riboli, Kay-Tee Khaw, Gabriele Nagel, R. Saracci, H. B. Bueno-De-Mesquita, S. Rinaldi, Carmen Martinez-Garcia, Petra H.M. Peeters, Salvatore Panico, Kim Overvad, Naomi E. Allen, Anne Tjønneland, Sheila Bingham, Michael Schulz, A. Olsen, Laure Dossus, Françoise Clavel-Chapelon, Majken K. Jensen, Franco Berrino, Carine Biessy, Irene D. Bezemer, Domenico Palli, Diederik E. Grobbee, J. Linseisen, Timothy J. Key, Rosario Tumino, J. Ramón Quirós, A. Thrichopoulou, Eva Ardanaz, Pilar Amiano, Maria Koliva, Carlotta Sacerdote, M. J. Tormo, G. Kyriazi, M. C. Boutron-Ruault, Rudolf Kaaks, Heiner Boeing, Nadia Slimani, Pamela Ferrari, Rinaldi, S, Peeters, Ph, Bezemer, Id, Dossus, L, Biessy, C, Sacerdote, C, Berrino, F, Panico, Salvatore, Palli, D, Tumino, R, Khaw, Kt, Bingham, S, Allen, Ne, Key, T, Jensen, Mk, Overvad, K, Olsen, A, Tjonneland, A, Amiano, P, Ardanaz, E, Agudo, A, MARTINEZ GARCIA, C, Quiros, Jr, Tormo, Mj, Nagel, G, Linseisen, J, Boeing, H, Schulz, M, Grobbee, De, BUENO DE MESQUITA, Hb, Koliva, M, Kyriazi, G, Thrichopoulou, A, BOUTRON RUAULT, Mc, CLAVEL CHAPELON, F, Ferrari, P, Slimani, N, Saracci, R, Riboli, E, and Kaaks, R. more...
- Subjects
Adult ,Male ,Cancer Research ,medicine.medical_specialty ,Alcohol Drinking ,Physiology ,Alcohol ,Models, Biological ,chemistry.chemical_compound ,Sex hormone-binding globulin ,Breast cancer ,Internal medicine ,Neoplasms ,Sex Hormone-Binding Globulin ,Epidemiology ,Medicine ,Humans ,Nutritional Physiological Phenomena ,ddc:610 ,Gonadal Steroid Hormones ,Aged ,Hematology ,biology ,business.industry ,Public health ,Middle Aged ,medicine.disease ,European Prospective Investigation into Cancer and Nutrition ,Postmenopause ,Endocrinology ,Oncology ,chemistry ,Premenopause ,Sex steroid ,biology.protein ,Female ,business - Abstract
Objective: Women with a moderate intake of alcohol have higher concentrations of sex steroids in serum, and higher risk of developing breast cancer, compared to non-drinkers. In the present study, we investigate the relationships between alcohol consumption and serum levels of sex steroids and sex-hormone binding globulin (SHBG) in 790 pre- and 1,291 post-menopausal women, who were part of the European Prospective Investigation into Cancer and Nutrition (EPIC). Methods: Serum levels of testosterone (T), androstenedione (Δ4), dehydroepiandrosterone sulphate (DHEAS), estrone (E 1), estradiol (E2) and SHBG were measured by direct immunoassays. Free T (fT) and free E2 (fE2) were calculated according to mass action laws. Current alcohol intake exposure to alcohol was assessed from dietary questionnaires. Results: Pre-menopausal women who consumed more than 25 g/day of alcohol had about 30% higher DHEAS, T and fT, 20% higher Δ4 and about 40% higher E1, concentrations compared to women who were non-consumers. E2, fE 2 and SHBG concentrations showed no association with current alcohol intake. In post-menopausal women, DHEAS, fT, T, Δ4, and E 1 concentrations were between 10% and 20% higher in women who consumed more than 25 g/day of alcohol compared to non-consumers. E2 or fE2 were not associated with alcohol intake at all. SHBG levels were about 15% lower in alcohol consumers compared to non-consumers. Conclusion: This study supports the hypothesis of an influence of alcohol intake on sex hormone concentrations in blood. © Springer Science+Business Media B.V. 2006. more...
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- 2006
16. Consumption of Vegetables and Fruits and Risk of Breast Cancer
- Author
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Naomi E. Allen, Jakob Linseisen, Timothy J. Key, Françoise Clavel-Chapelon, Anne Tjønneland, Gabriele Nagel, Sabina Sieri, Eva Ardanaz, Heiner Boeing, Elin Alsaker, Sheila Bingham, Dagrun Engeset, Antonia Trichopoulou, Petra H.M. Peeters, Pilar Amiano, Maria Koliva, Rosario Tumino, Per Lenner, H. Bas Bueno-de-Mesquita, Elio Riboli, Kay-Tee Khaw, Göran Hallmans, Carmen Navarro, José Ramón Quirós, Paolo Vineis, Carla H. van Gils, Teresa Norat, Elisabet Wirfält, Salvatore Panico, Domenico Palli, Carlos González, Anja Olsen, Theodora Psaltopoulou, Petra H. Lahmann, Nadia Slimani, Kim Overvad, Göran Berglund, Emmanuelle Kesse, Anne C. M. Thiébaut, Hendriek C. Boshuizen, María José Sánchez, Rudolf Kaaks, Eiliv Lund, VAN GILS, Ch, Peeters, Ph, BUENO DE MESQUITA, Hb, Boshuizen, Hc, Lahmann, Ph, CLAVEL CHAPELON, F, Thiebaut, A, Kesse, E, Sieri, S, Palli, D, Tumino, R, Panico, Salvatore, Vineis, P, Gonzalez, Ca, Ardanaz, E, Sanchez, Mj, Amiano, P, Navarro, C, Quiros, Jr, Key, Tj, Allen, N, Khaw, Kt, Bingham, Sa, Psaltopoulou, T, Koliva, M, Trichopoulou, A, Nagel, G, Linseisen, J, Boeing, H, Berglund, G, Wirfalt, E, Hallmans, G, Lenner, P, Overvad, K, Tjonneland, A, Olsen, A, Lund, E, Engeset, D, Alsaker, E, Norat, T, Kaaks, R, Slimani, N, and Riboli, E. more...
- Subjects
Adult ,Risk ,medicine.medical_specialty ,Context (language use) ,Breast Neoplasms ,Research Support ,Breast cancer ,Risk Factors ,Surveys and Questionnaires ,Environmental health ,Vegetables ,Journal Article ,Humans ,Medicine ,Prospective Studies ,Risk factor ,Prospective cohort study ,Non-U.S. Gov't ,Life Style ,Aged ,Gynecology ,Consumption (economics) ,business.industry ,Research Support, Non-U.S. Gov't ,Incidence ,Cancer ,General Medicine ,Middle Aged ,medicine.disease ,European Prospective Investigation into Cancer and Nutrition ,Diet ,Europe ,Relative risk ,Fruit ,Female ,business ,Cohort study - Abstract
CONTEXT: The intake of vegetables and fruits has been thought to protect against breast cancer. Most of the evidence comes from case-control studies, but a recent pooled analysis of the relatively few published cohort studies suggests no significantly reduced breast cancer risk is associated with vegetable and fruit consumption. OBJECTIVE: To examine the relation between total and specific vegetable and fruit intake and the incidence of breast cancer. DESIGN, SETTING, AND PARTICIPANTS: Prospective study of 285,526 women between the ages of 25 and 70 years, participating in the European Prospective Investigation Into Cancer and Nutrition (EPIC) study, recruited from 8 of the 10 participating European countries. Participants completed a dietary questionnaire in 1992-1998 and were followed up for incidence of cancer until 2002. MAIN OUTCOME MEASURES: Relative risks for breast cancer by total and specific vegetable and fruit intake. Analyses were stratified by age at recruitment and study center. Relative risks were adjusted for established breast cancer risk factors. RESULTS: During 1,486,402 person-years (median duration of follow-up, 5.4 years), 3659 invasive incident breast cancer cases were reported. No significant associations between vegetable or fruit intake and breast cancer risk were observed. Relative risks for the highest vs the lowest quintile were 0.98 (95% confidence interval [CI], 0.84-1.14) for total vegetables, 1.09 (95% CI , 0.94-1.25) for total fruit, and 1.05 (95% CI , 0.92-1.20) for fruit and vegetable juices. For 6 specific vegetable subgroups no associations with breast cancer risk were observed either. CONCLUSION: Although the period of follow-up is limited for now, the results suggest that total or specific vegetable and fruit intake is not associated with risk for breast cancer. more...
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- 2005
- Full Text
- View/download PDF
17. IGF-I, IGFBP-3 and breast cancer risk in women: The European Prospective Investigation into Cancer and Nutrition (EPIC)
- Author
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M. C. Boutron-Ruault, Rudolf Kaaks, P.A.H. van Noord, Antonio Agudo, Naomi E. Allen, Franco Berrino, Annekatrin Lukanova, Kim Overvad, Gabriele Nagel, Salvatore Panico, Kay-Tee Khaw, Sheila Bingham, Heiner Boeing, Carlotta Sacerdote, Timothy J. Key, Françoise Clavel-Chapelon, Aurelio Barricarte, Antonia Trichopoulou, H. B. Bueno-De-Mesquita, M-D Chirlaque, Carine Biessy, Bertrand Tehard, C. H. van Gils, Domenico Palli, Nadia Slimani, J. Linseisen, Elio Riboli, Dimitrios Trichopoulos, C. A. Gonzalez, Anne Tjønneland, A. Olsen, P. H. M. Peeters, Maria Koliva, Laure Dossus, Rosario Tumino, J. R. Quirós, Petra H. Lahmann, R. Saracci, S. Rinaldi, Nerea Larrañaga, Diederik E. Grobbee, Rinaldi, S, Peeters, Ph, Berrino, F, Dossus, L, Biessy, C, Olsen, A, Tjonneland, A, Overvad, K, CLAVEL CHAPELON, F, BOUTRON RUAULT, Mc, Tehard, B, Nagel, G, Linseisen, J, Boeing, H, Lahmann, Ph, Trichopoulou, A, Trichopoulos, D, Koliva, M, Palli, D, Panico, Salvatore, Tumino, R, Sacerdote, C, VAN GILS, Ch, VAN NOORD, P, Grobbee, De, BUENO DE MESQUITA, Hb, Gonzalez, Ca, Agudo, A, Chirlaque, Md, Barricarte, A, Larranaga, N, Quiros, Jr, Bingham, S, Khaw, Kt, Key, T, Allen, Ne, Lukanova, A, Slimani, N, Saracci, R, Riboli, E, and Kaaks, R. more...
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Adult ,Cancer Research ,medicine.medical_specialty ,Colorectal cancer ,Endocrinology, Diabetes and Metabolism ,Breast Neoplasms ,chemistry.chemical_compound ,Endocrinology ,Breast cancer ,Risk Factors ,medicine ,Humans ,Nutritional Physiological Phenomena ,ddc:610 ,Insulin-Like Growth Factor I ,Prospective cohort study ,Gynecology ,business.industry ,Obstetrics ,C-peptide ,Incidence ,Cancer ,Odds ratio ,Middle Aged ,medicine.disease ,Confidence interval ,European Prospective Investigation into Cancer and Nutrition ,Europe ,Insulin-Like Growth Factor Binding Protein 3 ,Oncology ,chemistry ,Case-Control Studies ,Female ,business - Abstract
Blood concentrations of insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3) have recently been associated with breast cancer risk, notably in women who developed breast cancer at a young age. Prospective studies published so far, however, were relatively small and odds ratio (OR) estimates imprecise. We present the results of a large prospective case-control study nested within the European Prospective Investigation into Cancer and Nutrition on total IGF-I, IGFBP-3 and breast cancer risk including 1081 incident cases of invasive breast cancer and 2098 matched control subjects. Increasing IGF-I and IGFBP-3 concentrations were associated with a significant increase in breast cancer risk in women who developed breast cancer after 50 years of age (highest vs lowest quintile OR 1.38 (95% confidence interval (CI) 1.02–1.86), P = 0.01, and 1.44 (95% CI 1.04–1.98), P = 0.01, respectively), but no relationship was observed in younger women (OR = 1.03 (95% CI 0.60–1.77), P = 0.81 for IGF-I, and OR = 0.92 (95% CI 0.50–1.70), P = 0.69 for IGFBP-3). There was, however, significant heterogeneity in the relationship of breast cancer with serum IGF-I and IGFBP-3 levels depending on the time interval between blood donation and tumor diagnosis. A reduction in breast cancer risk with increasing IGF-I concentrations was observed in cases with a diagnosis of cancer less than 2 years after blood donation, (OR = 0.76 (95% CI 0.57–1.03)), while an increase in risk was observed for women with a later diagnosis (above or equal to two years after blood collection, OR = 1.51 (95% CI 1.19–1.91)). A similar pattern was observed for IGFBP-3. This study confirms previous findings for an association of serum IGF-I and IGFBP-3 concentrations with breast cancer risk, particularly for women with a later diagnosis of cancer, but it does not support the hypothesis of an involvement of IGF-I in younger women. more...
18. Haplotype-based analysis of common variation in the acetyl-coA carboxylase alpha gene and breast cancer risk: a case-control study nested within the European Prospective Investigation into Cancer and Nutrition.
- Author
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Sinilnikova OM, McKay JD, Tavtigian SV, Canzian F, DeSilva D, Biessy C, Monnier S, Dossus L, Boillot C, Gioia L, Hughes DJ, Jensen MK, Overvad K, Tjonneland A, Olsen A, Clavel-Chapelon F, Chajès V, Joulin V, Linseisen J, Chang-Claude J, Boeing H, Dahm S, Trichopoulou A, Trichopoulos D, Koliva M, Khaw KT, Bingham S, Allen NE, Key T, Palli D, Panico S, Berrino F, Tumino R, Vineis P, Bueno-de-Mesquita HB, Peeters PH, van Gils CH, Lund E, Pera G, Quirós JR, Dorronsoro M, Martínez García C, Tormo MJ, Ardanaz E, Hallmans G, Lenner P, Berglund G, Manjer J, Riboli E, Lenoir GM, and Kaaks R more...
- Subjects
- Adult, Aged, Alleles, Breast Neoplasms enzymology, Case-Control Studies, Chi-Square Distribution, Europe, Female, Gene Frequency, Genetic Predisposition to Disease, Genotype, Humans, Logistic Models, Middle Aged, Risk Factors, Acetyl-CoA Carboxylase genetics, Breast Neoplasms genetics, Genetic Variation, Haplotypes genetics
- Abstract
A key fatty acid synthesis enzyme, acetyl-CoA carboxylase alpha (ACC-alpha), has been shown to be highly expressed in human breast cancer and other tumor types and also to specifically interact with the protein coded by one of two major breast cancer susceptibility genes BRCA1. We used a comprehensive haplotype analysis to examine the contribution of the ACC-alpha common genetic variation (allele frequency >5%) to breast cancer in a case-control study (1,588 cases/2,600 controls) nested within the European Prospective Investigation into Cancer and Nutrition. We identified 21 haplotype-tagging polymorphisms efficiently capturing common variation within 325 kb of ACC-alpha and surrounding sequences using genotype data from the HapMap project and our resequencing data. We found an effect on overall risk of breast cancer in homozygous carriers of one common haplotype [odds ratio (OR), 1.74; 95% confidence interval (95% CI), 1.03-2.94]. When the data were subdivided by menopausal status, we found statistical evidence of heterogeneity for two other common haplotypes (P value for heterogeneity = 0.016 and 0.045). In premenopausal women, the carriers of these haplotypes, compared with noncarriers, had an altered risk of breast cancer (OR, 0.70; 95% CI, 0.53-0.92 and OR, 1.35; 95% CI, 1.04-1.76). These findings were not significant after adjustment for multiple testing and therefore should be considered as preliminary and evaluated in larger independent studies. However, they suggest a possible role of the ACC-alpha common sequence variants in susceptibility to breast cancer and encourage studies of other genes involved in fatty acid synthesis. more...
- Published
- 2007
- Full Text
- View/download PDF
19. Physical activity and lung cancer risk in the European Prospective Investigation into Cancer and Nutrition Cohort.
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Steindorf K, Friedenreich C, Linseisen J, Rohrmann S, Rundle A, Veglia F, Vineis P, Johnsen NF, Tjønneland A, Overvad K, Raaschou-Nielsen O, Clavel-Chapelon F, Boutron-Ruault MC, Schulz M, Boeing H, Trichopoulou A, Kalapothaki V, Koliva M, Krogh V, Palli D, Tumino R, Panico S, Monninkhof E, Peeters PH, Boshuizen HC, Bueno-de-Mesquita HB, Chirlaque MD, Agudo A, Larrañaga N, Quirós JR, Martínez C, Barricarte A, Janzon L, Berglund G, Bingham S, Khaw KT, Key TJ, Norat T, Jenab M, Cust A, and Riboli E more...
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- Adult, Aged, Europe epidemiology, Female, Humans, Lung Neoplasms etiology, Male, Middle Aged, Nutritional Physiological Phenomena, Occupational Exposure adverse effects, Odds Ratio, Proportional Hazards Models, Prospective Studies, Recreation, Risk Assessment, Risk Factors, Sex Distribution, Lung Neoplasms epidemiology, Lung Neoplasms prevention & control, Motor Activity
- Abstract
Research conducted predominantly in male populations on physical activity and lung cancer has yielded inconsistent results. We examined this relationship among 416,277 men and women from the European Prospective Investigation into Cancer and Nutrition (EPIC). Detailed information on recent recreational, household and occupational physical activity, smoking habits and diet was assessed at baseline between 1992 and 2000. Relative risks (RR) were estimated using Cox regression. During 6.3 years of follow-up we identified 607 men and 476 women with incident lung cancer. We did not observe an inverse association between recent occupational, recreational or household physical activity and lung cancer risk in either males or females. However, we found some reduction in lung cancer risk associated with sports in males (adjusted RR = 0.71; 95% confidence interval 0.50-0.98; highest tertile vs. inactive group), cycling (RR = 0.73; 0.54-0.99) in females and non-occupational vigorous physical activity. For occupational physical activity, lung cancer risk was increased for unemployed men (adjusted RR = 1.57; 1.20-2.05) and men with standing occupations (RR = 1.35; 1.02-1.79) compared with sitting professions. There was no evidence of heterogeneity of physical activity associations across countries, or across any of the considered cofactors. For some histologic subtypes suggestive sex-specific reductions, limited by subgroup sizes, were observed, especially with vigorous physical activity. In total, our study shows no consistent protective associations of physical activity with lung cancer risk. It can be assumed that the elevated risks found for occupational physical activity are not produced mechanistically by physical activity itself but rather reflect exposure to occupation-related lung cancer risk factors. more...
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- 2006
- Full Text
- View/download PDF
20. Consumption of vegetables and fruits and risk of breast cancer.
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van Gils CH, Peeters PH, Bueno-de-Mesquita HB, Boshuizen HC, Lahmann PH, Clavel-Chapelon F, Thiébaut A, Kesse E, Sieri S, Palli D, Tumino R, Panico S, Vineis P, Gonzalez CA, Ardanaz E, Sánchez MJ, Amiano P, Navarro C, Quirós JR, Key TJ, Allen N, Khaw KT, Bingham SA, Psaltopoulou T, Koliva M, Trichopoulou A, Nagel G, Linseisen J, Boeing H, Berglund G, Wirfält E, Hallmans G, Lenner P, Overvad K, Tjønneland A, Olsen A, Lund E, Engeset D, Alsaker E, Norat T, Kaaks R, Slimani N, and Riboli E more...
- Subjects
- Adult, Aged, Breast Neoplasms epidemiology, Europe epidemiology, Female, Humans, Incidence, Life Style, Middle Aged, Prospective Studies, Risk, Risk Factors, Surveys and Questionnaires, Breast Neoplasms prevention & control, Diet, Fruit, Vegetables
- Abstract
Context: The intake of vegetables and fruits has been thought to protect against breast cancer. Most of the evidence comes from case-control studies, but a recent pooled analysis of the relatively few published cohort studies suggests no significantly reduced breast cancer risk is associated with vegetable and fruit consumption., Objective: To examine the relation between total and specific vegetable and fruit intake and the incidence of breast cancer., Design, Setting, and Participants: Prospective study of 285,526 women between the ages of 25 and 70 years, participating in the European Prospective Investigation Into Cancer and Nutrition (EPIC) study, recruited from 8 of the 10 participating European countries. Participants completed a dietary questionnaire in 1992-1998 and were followed up for incidence of cancer until 2002., Main Outcome Measures: Relative risks for breast cancer by total and specific vegetable and fruit intake. Analyses were stratified by age at recruitment and study center. Relative risks were adjusted for established breast cancer risk factors., Results: During 1,486,402 person-years (median duration of follow-up, 5.4 years), 3659 invasive incident breast cancer cases were reported. No significant associations between vegetable or fruit intake and breast cancer risk were observed. Relative risks for the highest vs the lowest quintile were 0.98 (95% confidence interval [CI], 0.84-1.14) for total vegetables, 1.09 (95% CI , 0.94-1.25) for total fruit, and 1.05 (95% CI , 0.92-1.20) for fruit and vegetable juices. For 6 specific vegetable subgroups no associations with breast cancer risk were observed either., Conclusion: Although the period of follow-up is limited for now, the results suggest that total or specific vegetable and fruit intake is not associated with risk for breast cancer. more...
- Published
- 2005
- Full Text
- View/download PDF
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