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42 results on '"Kolotas, Christos"'

14. Außergewöhnliche Manifestation eines Magenkarzinoms mit Meningeosis carcinomatosa und spinaler Metastase

Author

Cresto, Nicola, Barth, Alain, Arnold, Marlene, Weimann, Rosemarie, Gschossmann, Jürgen, Ochsenbein, Adrian, Kolotas, Christos, Peter, Hans-Jakob, Schiemann, Uwe, Cresto, Nicola, Barth, Alain, Arnold, Marlene, Weimann, Rosemarie, Gschossmann, Jürgen, Ochsenbein, Adrian, Kolotas, Christos, Peter, Hans-Jakob, and Schiemann, Uwe

Abstract

Zusammenfassung: Hintergrund:: Eine Meningeosis carcinomatosa ist eine seltene Komplikation solider Tumoren, wie Mamma-, Bronchial- oder gastrointestinale Karzinome. Klinisch manifestiert sie sich mit einer äußerst variablen Symptomatik wie z. B. radikulären Schmerzen mit oder ohne neurologische Ausfälle sowie Kopfschmerzen bis hin zu halluzinatorischen Reizsymptomen. Fallbeschreibung:: Berichtet wird über den seltenen Fall eines 57-jährigen Patienten mit neurologischen Reiz- und Ausfallsymptomen, hervorgerufen durch eine Meningeosis carcinomatosa und eine spinale Metastase bei einem asymptomatischen Siegelringzellkarzinom des Magens. Trotz kombinierter Radiochemotherapie verstarb der Patient bereits 4 Wochen nach Entlassung aus dem Spital an einer Hirnblutung. Schlussfolgerung:: Die Prognose der Meningeosis carcinomatosa ist bis heute unabhängig vom Primärtumor mit einer mittleren Überlebenszeit von 3-4 Monaten sehr schlecht

Published
2018

36. Reirradiation for Recurrent Neck Metastases of Head-and-Neck Tumors Using CT-Guided Interstitial 192Ir HDR Brachytherapy.

Author

Kolotas, Christos, Tselis, Nikolaos, Sommerlad, Manon, Röddiger, Sandra, Schnabel, Thomas, Baltas, Dimos, Kalogera-Fountzila, Anna, Fountzilas, George, and Zamboglou, Nikolaos

Subjects
METASTASIS, RADIOISOTOPE brachytherapy, TUMOR surgery, DISEASE remission, CANCER invasiveness, IMMUNOLOGICAL adjuvants, DRUG therapy
Abstract

Copyright of Strahlentherapie und Onkologie is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2007
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37. CT-Based Software for 3-D Localization and Reconstruction in Stepping Source Brachytherapy.

Author

Tsalpatouros, Alex, Baltas, Dimos, Kolotas, Christos, van der Laarse, R., Koutsouris, Dimitris, Uzunoglu, Nikolaos K., and Zamboglou, Nikolaos

Subjects
RADIOISOTOPE brachytherapy, CATHETERIZATION, COMPUTER software
Abstract

Describes innovative software for catheter localization and three-dimensional reconstruction in stepping source brachytherapy applications. Achievement of time saving in terms of other traditional reconstruction techniques; Usefulness of the device in the clinical practice.

Published
1997
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38. Effect of recombinant human granulocyte colony stimulating factor ( r-met H u G-CSF) as an adjunct to large-field radiotherapy: A phase I study

Author

Kolotas, Christos, >M.D., Zamboglou, Nikolaos, Ph.D., >M.D., Schnabel, Thomas, >M.D., Bojar, Hans, >M.D., Wintzer, Andreas, >M.D., Vogt, Hans-Georg, >M.D., Schmitt, Gerd, and >M.D.

Abstract

Purpose : To test the feasibility of recombinant human granulocyte colony stimulating factor application during large-field radiotherapy. Methods and Materials : Fifteen patients with clinically and histologically proven malignancy who received large-field radiotherapy entered this study. Administration of recombinant granulocyte colony stimulating factor (G-CSF) at a dose of 300 μg subcutaneously was started on Friday and was continued on Saturday and Sunday after the first radiotherapy treatment, which began on the Monday before. In this way four courses of G-CSF were applied every Friday, Saturday, and Sunday during the radiotherapy period. Absolute neutrophil cell (ANC) and blood counts were monitored twice a week and compared to a second group of 15 patients who received large-field radiotherapy without G-CSF. Before and at the end of every cycle of G-CSF, ANC, blood counts, and biochemistry were measured. We compared the myelotoxicity of the patients treated with G-CSF with 15 patients without G-CSF treated at the same period with large-field radiotherapy, in match pair technique. Results : G-CSF increased the ANC throughout the period of irradiation, and the treatment time needed for completing radiotherapy was shorter in the group who received G-CSF. Fourteen of 15 patients who received G-CSF treatment completed large-field radiotherapy without pause. Only 1 of 15 patients not receiving G-CSF was able to receive radiation treatment on schedule. Patients receiving G-CSF completed treatment with the mantle-field technique in 24 days and those with the abdominal bath technique in 26.5 days. Conversely, patients treated without G-CSF completed treatment with the mantle-field technique in 30.5 days and those with the abdominal bath technique in 36 days. The most frequent side effect was musculoskeletal pain. Conclusion : The prophylactic application of G-CSF during large-field radiotherapy before the onset of neutropenia was feasible in this schedule. Whether or not this shortening of treatment duration will translate into an improvement in efficacy is not clear.

Published
1996
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40. Außergewöhnliche Manifestation eines Magenkarzinoms mit Meningeosis carcinomatosa und spinaler Metastase

Author

Cresto, Nicola, Barth, Alain, Arnold, Marlene, Weimann, Rosemarie, Gschossmann, Jürgen, Ochsenbein, Adrian, Kolotas, Christos, Peter, Hans-Jakob, Schiemann, Uwe, Cresto, Nicola, Barth, Alain, Arnold, Marlene, Weimann, Rosemarie, Gschossmann, Jürgen, Ochsenbein, Adrian, Kolotas, Christos, Peter, Hans-Jakob, and Schiemann, Uwe

Abstract

Zusammenfassung: Hintergrund:: Eine Meningeosis carcinomatosa ist eine seltene Komplikation solider Tumoren, wie Mamma-, Bronchial- oder gastrointestinale Karzinome. Klinisch manifestiert sie sich mit einer äußerst variablen Symptomatik wie z. B. radikulären Schmerzen mit oder ohne neurologische Ausfälle sowie Kopfschmerzen bis hin zu halluzinatorischen Reizsymptomen. Fallbeschreibung:: Berichtet wird über den seltenen Fall eines 57-jährigen Patienten mit neurologischen Reiz- und Ausfallsymptomen, hervorgerufen durch eine Meningeosis carcinomatosa und eine spinale Metastase bei einem asymptomatischen Siegelringzellkarzinom des Magens. Trotz kombinierter Radiochemotherapie verstarb der Patient bereits 4 Wochen nach Entlassung aus dem Spital an einer Hirnblutung. Schlussfolgerung:: Die Prognose der Meningeosis carcinomatosa ist bis heute unabhängig vom Primärtumor mit einer mittleren Überlebenszeit von 3-4 Monaten sehr schlecht

41. Hypofractionated accelerated CT-guided interstitial 192Ir-HDR-Brachytherapy as re-irradiation in inoperable recurrent cervical lymphadenopathy from head and neck cancer

Author

Tselis, Nikolaos, Ratka, Markus, Vogt, Hans-Georg, Kolotas, Christos, Baghi, Mehran, Baltas, Dimos, Fountzilas, George, Georgoulias, Vassilios, Ackermann, Hanns, and Zamboglou, Nikolaos

Subjects
*HEAD & neck cancer treatment, *CANCER tomography, *METASTASIS, *CANCER relapse, *SURVIVAL analysis (Biometry), *RADIOEMBOLIZATION, *LYMPH node diseases
Abstract

Abstract: Background: Despite significant improvements in the treatment of head and neck cancer (HNC), lymph node recurrences remain a clinical challenge after primary radiotherapy. The value of interstitial (IRT) brachytherapy (BRT) for control of lymph node recurrence remains unclear. In order to clarify its role a retrospective review was undertaken on the value of computed tomography (CT)-guided IRT high-dose-rate (HDR)-BRT in isolated recurrent disease from HNC. Patients and methods: From 2000 to 2007, 74 patients were treated for inoperable recurrent cervical lymphadenopathy. All patients had previously been treated with radical radiotherapy or chemoradiation with or without surgery. The HDR-BRT delivered a median salvage dose of 30.0Gy (range, 12.0–36.0Gy) in twice-daily fractions of 2.0–5.0Gy in 71 patients and of 30.0Gy (range, 10.0–36.0Gy) in once-daily fractions of 6.0–10.0Gy in three patients. Results: The overall and disease-free survival rates at one, two and three years were 42%, 19%, 6%, and 42%, 37% and 19%, respectively. The local control probability at one, two and three years was 67% at all three time points. Grade III–IV complications occurred in 13% of patients. Conclusions: In patients with inoperable recurrent neck disease from HNC, hypofractionated accelerated CT-guided IRT-HDR-BRT can play an important role in providing palliation and tumor control. [ABSTRACT FROM AUTHOR]

Published
2011
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42. [Extraordinary manifestation of a gastric carcinoma by leptomeningeal carcinomatosis and spinal metastasis].

Author

Cresto N, Barth A, Arnold M, Weimann R, Gschossmann J, Ochsenbein AF, Kolotas C, Peter HJ, and Schiemann U

Subjects
Biopsy, Carcinoma, Signet Ring Cell diagnosis, Carcinoma, Signet Ring Cell pathology, Carcinoma, Signet Ring Cell therapy, Diagnosis, Differential, Disease Progression, Gastroscopy, Humans, Lumbar Vertebrae, Lymphatic Metastasis, Magnetic Resonance Imaging, Male, Meningeal Neoplasms diagnosis, Meningeal Neoplasms pathology, Meningeal Neoplasms therapy, Middle Aged, Neoplasm Staging, Neurologic Examination, Polyradiculopathy diagnosis, Polyradiculopathy etiology, Sacrum, Spinal Cord Neoplasms diagnosis, Spinal Cord Neoplasms pathology, Spinal Cord Neoplasms therapy, Stomach pathology, Stomach Neoplasms pathology, Stomach Neoplasms therapy, Carcinoma, Signet Ring Cell secondary, Meningeal Neoplasms secondary, Spinal Cord Neoplasms secondary, Stomach Neoplasms diagnosis
Abstract

Background: Leptomeningeal carcinomatosis is a rare complication of solid tumors, e. g., breast, lung and gastrointestinal carcinomas. Clinical manifestations are variable with radicular pains with or without neurologic deficiencies as well as headache and hallucinations., Case Report: The rare case of a 57-year-old patient with neurologic symptoms caused by a leptomeningeal carcinomatosis and a spinal metastasis of an asymptomatic signet-ring cell gastric carcinoma is reported. In spite of combined radiochemotherapy the patient died already 4 weeks after discharge from hospital due to an intracerebral hemorrhage., Conclusion: Until today, prognosis of leptomeningeal carcinomatosis is poor with a median survival between 3-4 months independently of the primary tumor.

Published
2007
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