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354 results on '"Kommoss, F."'

1. Mikrovaskuläre Veränderungen bei COVID-19

Author

Wagner, W. L., Hellbach, K., Fiedler, M. O., Salg, G. A., Wehrse, E., Ziener, C. H., Merle, U., Eckert, C., Weber, T. F., Stiller, W., Wielpütz, M. O., Dullin, C., Kenngott, H. G., Schlemmer, H.-P., Weigand, M. A., Schirmacher, P., Longerich, T., Kauczor, H.-U., Kommoss, F. K.-F., and Schwab, C.

Published
2020
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7. Genomic characterization of DICER1-associated neoplasms uncovers molecular classes.

Author

Kommoss, F.K.F., Chong, A.S., Chong, A.L., Pfaff, E., Jones, D.T.W., Hiemcke-Jiwa, L.S., Kester, L.A., Flucke, U.E., Gessler, M., Schrimpf, D., Sahm, F., Clarke, B.A., Stewart, C.J.R., Wang, Yemin, Gilks, C.B., Kommoss, F., Huntsman, D.G., Schüller, U., Koelsche, C., Glenn McCluggage, W., Deimling, A. von, Foulkes, W.D., Kommoss, F.K.F., Chong, A.S., Chong, A.L., Pfaff, E., Jones, D.T.W., Hiemcke-Jiwa, L.S., Kester, L.A., Flucke, U.E., Gessler, M., Schrimpf, D., Sahm, F., Clarke, B.A., Stewart, C.J.R., Wang, Yemin, Gilks, C.B., Kommoss, F., Huntsman, D.G., Schüller, U., Koelsche, C., Glenn McCluggage, W., Deimling, A. von, and Foulkes, W.D.

Abstract

Item does not contain fulltext, DICER1 syndrome is a tumor predisposition syndrome that is associated with up to 30 different neoplastic lesions, usually affecting children and adolescents. Here we identify a group of mesenchymal tumors which is highly associated with DICER1 syndrome, and molecularly distinct from other DICER1-associated tumors. This group of DICER1-associated mesenchymal tumors encompasses multiple well-established clinicopathological tumor entities and can be further divided into three clinically meaningful classes designated "low-grade mesenchymal tumor with DICER1 alteration" (LGMT DICER1), "sarcoma with DICER1 alteration" (SARC DICER1), and primary intracranial sarcoma with DICER1 alteration (PIS DICER1). Our study not only provides a combined approach to classify DICER1-associated neoplasms for improved clinical management but also suggests a role for global hypomethylation and other recurrent molecular events in sarcomatous differentiation in mesenchymal tumors with DICER1 alteration. Our results will facilitate future investigations into prognostication and therapeutic approaches for affected patients.

Published
2023

8. Improved preoperative risk stratification in endometrial carcinoma patients: external validation of the ENDORISK Bayesian network model in a large population-based case series.

Author

Grube, M., Reijnen, C., Lucas, P.J.F., Kommoss, F., Kommoss, F.K.F., Brucker, S.Y., Walter, C.B., Oberlechner, E., Krämer, Bernhard, Andress, J., Neis, F., Staebler, A., Pijnenborg, J.M.A., Kommoss, S., Grube, M., Reijnen, C., Lucas, P.J.F., Kommoss, F., Kommoss, F.K.F., Brucker, S.Y., Walter, C.B., Oberlechner, E., Krämer, Bernhard, Andress, J., Neis, F., Staebler, A., Pijnenborg, J.M.A., and Kommoss, S.

Abstract

01 juli 2023, Item does not contain fulltext, PURPOSE: Preoperative risk stratification of newly diagnosed endometrial carcinoma (EC) patients has been hindered by only moderate prediction performance for many years. Recently ENDORISK, a Bayesian network model, showed high predictive performance. It was the aim of this study to validate ENDORISK by applying the model to a population-based case series of EC patients. METHODS: ENDORISK was applied to a retrospective cohort of women surgically treated for EC from 2003 to 2013. Prediction accuracy for LNM as well as 5-year DSS was investigated. The model's overall performance was quantified by the Brier score, discriminative performance by area under the curve (AUC). RESULTS: A complete dataset was evaluable from 247 patients. 78.1% cases were endometrioid histotype. The majority of patients (n = 156;63.2%) had stage IA disease. Overall, positive lymph nodes were found in 20 (8.1%) patients. Using ENDORISK predicted probabilities, most (n = 156;63.2%) patients have been assigned to low or very low risk group with a false-negative rate of 0.6%. AUC for LNM prediction was 0.851 [95% confidence interval (CI) 0.761-0.941] with a Brier score of 0.06. For 5-year DSS the AUC was 0.698 (95% CI 0.595-0.800) as Brier score has been calculated 0.09. CONCLUSIONS: We were able to successfully validate ENDORISK for prediction of LNM and 5-year DSS. Next steps will now have to focus on ENDORISK performance in daily clinical practice. In addition, incorporating TCGA-derived molecular subtypes will be of key importance for future extended use. This study may support further promoting of data-based decision-making tools for personalized treatment of EC.

Published
2023

9. Age-dependent differences in borderline ovarian tumours (BOT) regarding clinical characteristics and outcome: results from a sub-analysis of the Arbeitsgemeinschaft Gynaekologische Onkologie (AGO) ROBOT study

Author

Trillsch, F., Mahner, S., Woelber, L., Vettorazzi, E., Reuss, A., Ewald-Riegler, N., de Gregorio, N., Fotopoulou, C., Schmalfeldt, B., Burges, A., Hilpert, F., Fehm, T., Meier, W., Hillemanns, P., Hanker, L., Hasenburg, A., Strauss, H.G., Hellriegel, M., Wimberger, P., Baumann, K., Keyver-Paik, M.D., Canzler, U., Wollschlaeger, K., Forner, D., Pfisterer, J., Schroeder, W., Muenstedt, K., Richter, B., Kommoss, F., Hauptmann, S., and du Bois, A.

Published
2014
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10. Borderlinetumoren des Ovars

Author

Breitbach, G. -P., Kommoss, F., Kreienberg, Rolf, editor, du Bois, Andreas, editor, Pfisterer, Jacobus, editor, Schindelmann, Sabine, editor, and Schmalfeldt, Barbara, editor

Published
2009
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11. Anatomie und Embryologie

Author

Kommoss, F., Kreienberg, Rolf, editor, du Bois, Andreas, editor, Pfisterer, Jacobus, editor, Schindelmann, Sabine, editor, and Schmalfeldt, Barbara, editor

Published
2009
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12. Pathologie

Author

Kommoss, F., Kreienberg, Rolf, editor, du Bois, Andreas, editor, Pfisterer, Jacobus, editor, Schindelmann, Sabine, editor, and Schmalfeldt, Barbara, editor

Published
2009
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13. Gutartige Tumoren des Ovars

Author

Münstedt, K., Hackethal, A., Kommoss, F., and Schmalfeldt, B.

Abstract

Zusammenfassung: Gutartige Tumoren des Ovars stellen eine klinische Herausforderung dar, denn derzeitige klinische diagnostische Möglichkeiten erlauben keine eindeutige Abgrenzung zu malignen Tumoren. Ein wichtiger Grund dafür sind die vielfältigen Erscheinungsbilder von Ovarialtumoren, die u. a. auf der Anwesenheit von unterschiedlichsten Zelltypen im Ovar beruhen. Aufgrund dieser Problematik ist eine sorgfältige präoperative Abklärung der Befunde sowie eine intensive Aufklärung der Patientinnen insbesondere in den Fällen erforderlich, die nicht mit ausreichender Wahrscheinlichkeit als gutartig eingestuft werden können. In diesen Fällen sollte immer ein onkochirurgisch sinnvolles Konzept gewählt werden, bei dem darauf geachtet werden muss, dass es nicht zu Zystenrupturen kommt. Unter Berücksichtigung von Alter und Kinderwunsch sollte ggf. eine Adnektomie erfolgen. Eine histologische Untersuchung am Paraffinschnitt wird schließlich eine eindeutige Zuordnung des Befundes erlauben. Hierdurch kann im Falle benigner Ovarialtumoren unnötige Radikalität und Morbidität vermieden werden.

Published
2024
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15. Molekulare Diagnostik

Author

Kommoss, F., Ridder, R., Beckmann, Matthias W., editor, Fasching, Peter Andreas, editor, Dall, Peter, editor, Krüssel, Jan-Steffen, editor, Niederacher, Dieter, editor, and Tutschek, Boris, editor

Published
2002
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16. Trophoblasterkrankungen

Author

Dallenbach-Hellweg, G., Kommoss, F., Hantschmann, P., Assemi, C., Kindermann, G., Berg, Dietrich, editor, Diedrich, Klaus, editor, and Rauskolb, Rüdiger, editor

Published
2000
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18. Validated biomarker assays confirm that ARID1A loss is confounded with MMR deficiency, CD8(+) TIL infiltration, and provides no independent prognostic value in endometriosis-associated ovarian carcinomas

Author

Heinze, K, Nazeran, TM, Lee, S, Kramer, P, Cairns, ES, Chiu, DS, Leung, SCY, Kang, EY, Meagher, NS, Kennedy, CJ, Boros, J, Kommoss, F, Vollert, H-W, Heitze, F, du Bois, A, Harter, P, Grube, M, Kraemer, B, Staebler, A, Kommoss, FKF, Heublein, S, Sinn, H-P, Singh, N, Laslavic, A, Elishaev, E, Olawaiye, A, Moysich, K, Modugno, F, Sharma, R, Brand, AH, Harnett, PR, DeFazio, A, Fortner, RT, Lubinski, J, Lener, M, Toloczko-Grabarek, A, Cybulski, C, Gronwald, H, Gronwald, J, Coulson, P, El-Bahrawy, MA, Jones, ME, Schoemaker, MJ, Swerdlow, AJ, Gorringe, KL, Campbell, I, Cook, L, Gayther, SA, Carney, ME, Shvetsov, YB, Hernandez, BY, Wilkens, LR, Goodman, MT, Mateoiu, C, Linder, A, Sundfeldt, K, Kelemen, LE, Gentry-Maharaj, A, Widschwendter, M, Menon, U, Bolton, KL, Alsop, J, Shah, M, Jimenez-Linan, M, Pharoah, PDP, Brenton, JD, Cushing-Haugen, KL, Harris, HR, Doherty, JA, Gilks, B, Ghatage, P, Huntsman, DG, Nelson, GS, Tinker, A, Lee, C-H, Goode, EL, Nelson, BH, Ramus, SJ, Kommoss, S, Talhouk, A, Kobel, M, Anglesio, MS, Heinze, K, Nazeran, TM, Lee, S, Kramer, P, Cairns, ES, Chiu, DS, Leung, SCY, Kang, EY, Meagher, NS, Kennedy, CJ, Boros, J, Kommoss, F, Vollert, H-W, Heitze, F, du Bois, A, Harter, P, Grube, M, Kraemer, B, Staebler, A, Kommoss, FKF, Heublein, S, Sinn, H-P, Singh, N, Laslavic, A, Elishaev, E, Olawaiye, A, Moysich, K, Modugno, F, Sharma, R, Brand, AH, Harnett, PR, DeFazio, A, Fortner, RT, Lubinski, J, Lener, M, Toloczko-Grabarek, A, Cybulski, C, Gronwald, H, Gronwald, J, Coulson, P, El-Bahrawy, MA, Jones, ME, Schoemaker, MJ, Swerdlow, AJ, Gorringe, KL, Campbell, I, Cook, L, Gayther, SA, Carney, ME, Shvetsov, YB, Hernandez, BY, Wilkens, LR, Goodman, MT, Mateoiu, C, Linder, A, Sundfeldt, K, Kelemen, LE, Gentry-Maharaj, A, Widschwendter, M, Menon, U, Bolton, KL, Alsop, J, Shah, M, Jimenez-Linan, M, Pharoah, PDP, Brenton, JD, Cushing-Haugen, KL, Harris, HR, Doherty, JA, Gilks, B, Ghatage, P, Huntsman, DG, Nelson, GS, Tinker, A, Lee, C-H, Goode, EL, Nelson, BH, Ramus, SJ, Kommoss, S, Talhouk, A, Kobel, M, and Anglesio, MS

Published
2022

25. 113 Improved preoperative risk stratification in endometrial cancer: External validation of the ENDORISK network model in a population-based case series

Author

Grube, M, primary, Reijnen, C, additional, Lucas, PJ, additional, Kommoss, F, additional, Kommoss, FK, additional, Brucker, SY, additional, Oberlechner, E, additional, Krämer, B, additional, Andress, J, additional, Neis, F, additional, Staebler, A, additional, Pijnenborg, JM, additional, and Kommoss, S, additional

Published
2021
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26. 382 Molecular classification of endometrial carcinoma substantially changing risk-assessment: Results from a european multicentre initiative

Author

Kommoss, S, primary, Grube, M, additional, Knoll, K, additional, Lum, A, additional, Brambs, C, additional, Pauly, N, additional, Kommoss, F, additional, Heublein, S, additional, Battista, M, additional, Mittelstadt, S, additional, Rohner, A, additional, Preaetorius, T, additional, Hasenburg, A, additional, Ataseven, B, additional, Talhouk, A, additional, Diebold, J, additional, Zeimet, AG, additional, Staebler, A, additional, and Mcalpine, J, additional

Published
2021
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27. VEGF-A and i-NOS expression are prognostic factors in serous epithelial ovarian carcinomas after complete surgical resection

Author

Engels, K., Bois, A. du, Harter, P., Fisseler-Eckhoff, A., Kommoss, F., Stauber, R., Kaufmann, M., Nekljudova, V., and Loibl, S.

Subjects
Ovarian cancer -- Prognosis, Ovarian cancer -- Genetic aspects, Ovarian cancer -- Diagnosis, Gene expression -- Research, Gene expression -- Physiological aspects, Immunohistochemistry -- Usage, Gynecology, Operative -- Patient outcomes, Health
Published
2009

41. 454 Study in progress: international retrospective study on lymphadenectomy in endometrioid ovarian carcinoma patients with early stage disease (LEOPARD)

Author

Krämer, P, primary, Grube, M, additional, Renno, T, additional, Brar, H, additional, McAlpine, JN, additional, de Kroon, CD, additional, Heitz, F, additional, Heublein, S, additional, Manchanda, R, additional, Plante, M, additional, Bachvarov, D, additional, Zeimet, AG, additional, Schmalfeldt, B, additional, Wimberger, P, additional, Lampe, B, additional, Trillsch, F, additional, Grimm, C, additional, Staebler, A, additional, Kommoss, F, additional, Talhouk, A, additional, Köbel, M, additional, Anglesio, MS, additional, and Kommoss, S, additional

Published
2020
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42. Molecular stratification of clear cell ovarian carcinomas

Author

Feil, L, additional, Senz, J, additional, Ta, M, additional, Huvila, J, additional, Greif, K, additional, Krämer, B, additional, Brucker, S, additional, Grimm, C, additional, Bartl, T, additional, Zeder-Gösz, C, additional, Schmöckel, E, additional, Trillsch, F, additional, Mahner, S, additional, Kommoss, F, additional, Lehr, H.-A, additional, Wiedemeyer, K, additional, Köbel, M, additional, Staebler, A, additional, Anglesio, M, additional, and Kommoss, S, additional

Published
2020
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43. Anwendung der molekularen Risikostratifikation des Endometriums auf das endometrioide Ovarialkarzinom- eine retrospektive, internationale Multizenterstudie

Author

Heitz, F, additional, Krämer, P, additional, Talhouk, A, additional, MA, Brett, additional, DS, Chiu, additional, ES, Cairns, additional, Scheunhage, D, additional, RF, Hammond, additional, Senz, J, additional, Leung, S, additional, Hartkopf, A, additional, Krämer, B, additional, Brucker, S, additional, du Bois, A, additional, Harter, P, additional, FK, Kommoss, additional, Heublein, S, additional, Kommoss, F, additional, JN, McAlpine, additional, Singh, N, additional, Bosse, T, additional, Köbel, M, additional, MS, Anglesio, additional, Staebler, A, additional, and Kommoss, S, additional

Published
2020
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