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7. Direct inhibition of the transforming growth factor‐β pathway by protein‐bound polysaccharide through inactivation of Smad2 signaling

Author

Ono, Yoshihiro, primary, Hayashida, Tetsu, additional, Konagai, Ayano, additional, Okazaki, Hiroshi, additional, Miyao, Kazuhiro, additional, Kawachi, Shigeyuki, additional, Tanabe, Minoru, additional, Shinoda, Masahiro, additional, Jinno, Hiromitsu, additional, Hasegawa, Hirotoshi, additional, Kitajima, Masaki, additional, and Kitagawa, Yuko, additional

Published
2011
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8. Correlation Between NKG2DL Expression and Antitumor Effect of Protein-bound Polysaccharide-K in Tumor-bearing Mouse Models.

Author

Konagai A, Yoshimura K, Hazama S, Yamamoto N, Aoki K, Ueno T, Fujioka M, Iijima H, Kato M, Uchida M, Wada T, Inoue M, Asao T, Fuse M, Wada S, Kuramasu A, Kamei R, Takeda S, Yamamoto S, Yoshino S, Oka M, and Nagano H

Subjects
Animals, CD8-Positive T-Lymphocytes drug effects, Cell Line, Tumor, Gene Expression Regulation, Neoplastic drug effects, Humans, Ligands, Mice, Minor Histocompatibility Antigens biosynthesis, NK Cell Lectin-Like Receptor Subfamily K biosynthesis, Neoplasms genetics, Neoplasms pathology, Nuclear Matrix-Associated Proteins biosynthesis, Nucleocytoplasmic Transport Proteins biosynthesis, Xenograft Model Antitumor Assays, Fungal Proteins administration & dosage, Minor Histocompatibility Antigens genetics, NK Cell Lectin-Like Receptor Subfamily K genetics, Neoplasms drug therapy, Nuclear Matrix-Associated Proteins genetics, Nucleocytoplasmic Transport Proteins genetics, Polysaccharides administration & dosage
Abstract

Background/aim: We investigated the relationship between the expression of natural killer group 2, member D ligands (NKG2DLs) and the antitumor effects of protein-bound polysaccharide-K (PSK)., Materials and Methods: PSK was administered to evaluate its effectiveness against tumor growth. The expression of Rae-1 and H60 were analyzed in multiple cell lines., Results: PSK showed the highest antitumor effects in mice implanted with cells expressing neither Rae-1 nor H60. PSK had little antitumor effect in mice implanted with cells expressing both Rae-1 and H60. A correlation between the expression of NKG2DLs and the antitumor effect of PSK was observed. After PSK administration, INF-γ production in CD8 + T cells increased in mice with cells expressing neither Rae-1 nor H60, but did not change in mice implanted with cells expressing both Rae-1 and H60., Conclusion: We demonstrated that the expression of NKG2DLs affects tumor immunity and the efficacy of immuno therapy in tumor-bearing mouse model., (Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)

Published
2017
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