36 results on '"Konak M"'
Search Results
2. Iodine status of Turkish pregnant women and their offspring: A national cross-sectional survey
- Author
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Satar, M., Buyukkurt, S., Simsek, H., Eroglu, C., Yetkinel, S., Saygili Karagol, B., Karasahin, K.E., Celik, H.T., Beksac, M.S., Tanacan, A., Ecevit, A.N., Tugcu, A.U., Soylemez, F., Okulu, E., Onal, E.E., Oygur, N., Kumru, S., Kaynak Turkmen, M., Turan, O.D., Cizmeci, M.N., Guney Varal, I., Dogan, P., Korkmazer, E., Arayici, S., Cetin, H., Cirali, C., Ozdemir, O.M.A., Ertugrul, S., Yolbas, I., Findik, M.F., Acunas, B., Varol, G.F., Taskin, E., Aydin, M., Caglar, A., Tekgunduz, K.S., Kara, M., Tekin, N., Velipasaoglu, M., Sarikabadayi, Y.U., Abbasoglu, A., Basar, D., El, C., Dolapcioglu, K., Turhan, A.H., Desteli, G., Uslu, S., Koc Bebek, A., Topcuoglu, S., Aksoy Okan, M., Eroglu, M., Erener Ercan, T., Celik, A., Kaya Narter, F., Sancak, S., Cetinkaya, M., Seckin, K.D., Gursoy, T., Celik, E., Coban, A., Aygun, E., Bayraktar, B., Kilicoglu Dane, P.B., Bozdag, S., Durankus, F., Ozdemir, H., Guclu, M., Hamilcikan, S., Kovalak, E.E., Gundogdu, S., Ciler Erden, E., Yilmaz, A., Ataoglu, N., Ataoglu, E., Oguz, D., Oncel, M.Y., Koyuncu Arslan, M., Akar, M., Olukman, O., Ozer, I., Aydin, C., Ozturk, A., Unal, M., Ozudogru, S.E., Aliefendioglu, D., Guzoglu, N., Arisoy, A.E., Senel, Y., Altunhan, H., Yilmaz, F.H., Konak, M., Ozdemir, R., Turgut, H., Gokce, I.K., Faydali, S., Tanriverdi, S., Ozer, E., Celik, Y., Durukan, H., Caner, I., Genc, G., Aygun, C., Tosun, M., Yesilirmak, C., Erden, T., Aslan, Y., Mutlu, M., Aran, T., Kader, S., Bor, M., Ozkan, I., Hilali, N.G., Hakyemez Toptan, H., Memur, S., Sari, S., Aydemir, C., Ekmen, S., Yurtcu, E., Sahin, S., Kanburoglu, M.K., Gurlek, B., Oguz, B, Bozkurt, O., Yucesoy, E., Tunc, T., Vural, Mehmet, Koc, Esin, Evliyaoglu, Olcay, Acar, Hazal Cansu, Aydin, Abdurrahman Fatih, Kucukgergin, Canan, Apaydin, Gozde, Erginoz, Ethem, Babazade, Xanim, Sharifova, Sabina, and Perk, Yildiz
- Published
- 2021
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3. Iodine status of Turkish pregnant women and their offspring: A national cross-sectional survey
- Author
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Vural, Mehmet, primary, Koc, Esin, additional, Evliyaoglu, Olcay, additional, Acar, Hazal Cansu, additional, Aydin, Abdurrahman Fatih, additional, Kucukgergin, Canan, additional, Apaydin, Gozde, additional, Erginoz, Ethem, additional, Babazade, Xanim, additional, Sharifova, Sabina, additional, Perk, Yildiz, additional, Satar, M., additional, Buyukkurt, S., additional, Simsek, H., additional, Eroglu, C., additional, Yetkinel, S., additional, Saygili Karagol, B., additional, Karasahin, K.E., additional, Celik, H.T., additional, Beksac, M.S., additional, Tanacan, A., additional, Ecevit, A.N., additional, Tugcu, A.U., additional, Soylemez, F., additional, Okulu, E., additional, Onal, E.E., additional, Oygur, N., additional, Kumru, S., additional, Kaynak Turkmen, M., additional, Turan, O.D., additional, Cizmeci, M.N., additional, Guney Varal, I., additional, Dogan, P., additional, Korkmazer, E., additional, Arayici, S., additional, Cetin, H., additional, Cirali, C., additional, Ozdemir, O.M.A., additional, Ertugrul, S., additional, Yolbas, I., additional, Findik, M.F., additional, Acunas, B., additional, Varol, G.F., additional, Taskin, E., additional, Aydin, M., additional, Caglar, A., additional, Tekgunduz, K.S., additional, Kara, M., additional, Tekin, N., additional, Velipasaoglu, M., additional, Sarikabadayi, Y.U., additional, Abbasoglu, A., additional, Basar, D., additional, El, C., additional, Dolapcioglu, K., additional, Turhan, A.H., additional, Desteli, G., additional, Uslu, S., additional, Koc Bebek, A., additional, Topcuoglu, S., additional, Aksoy Okan, M., additional, Eroglu, M., additional, Erener Ercan, T., additional, Celik, A., additional, Kaya Narter, F., additional, Sancak, S., additional, Cetinkaya, M., additional, Seckin, K.D., additional, Gursoy, T., additional, Celik, E., additional, Coban, A., additional, Aygun, E., additional, Bayraktar, B., additional, Kilicoglu Dane, P.B., additional, Bozdag, S., additional, Durankus, F., additional, Ozdemir, H., additional, Guclu, M., additional, Hamilcikan, S., additional, Kovalak, E.E., additional, Gundogdu, S., additional, Ciler Erden, E., additional, Yilmaz, A., additional, Ataoglu, N., additional, Ataoglu, E., additional, Oguz, D., additional, Oncel, M.Y., additional, Koyuncu Arslan, M., additional, Akar, M., additional, Olukman, O., additional, Ozer, I., additional, Aydin, C., additional, Ozturk, A., additional, Unal, M., additional, Ozudogru, S.E., additional, Aliefendioglu, D., additional, Guzoglu, N., additional, Arisoy, A.E., additional, Senel, Y., additional, Altunhan, H., additional, Yilmaz, F.H., additional, Konak, M., additional, Ozdemir, R., additional, Turgut, H., additional, Gokce, I.K., additional, Faydali, S., additional, Tanriverdi, S., additional, Ozer, E., additional, Celik, Y., additional, Durukan, H., additional, Caner, I., additional, Genc, G., additional, Aygun, C., additional, Tosun, M., additional, Yesilirmak, C., additional, Erden, T., additional, Aslan, Y., additional, Mutlu, M., additional, Aran, T., additional, Kader, S., additional, Bor, M., additional, Ozkan, I., additional, Hilali, N.G., additional, Hakyemez Toptan, H., additional, Memur, S., additional, Sari, S., additional, Aydemir, C., additional, Ekmen, S., additional, Yurtcu, E., additional, Sahin, S., additional, Kanburoglu, M.K., additional, Gurlek, B., additional, Oguz, B, additional, Bozkurt, O., additional, Yucesoy, E., additional, and Tunc, T., additional
- Published
- 2021
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4. Turkey (TR-ROP study): a prospective, multicentre study in 69 neonatal
- Author
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Bas, AY, Demirel, N, Koc, E, Isik, DU, Hirfanoglu, IM, Tunc, T, Sari, FN, Karatekin, G, Koklu, E, Altunhan, H, Turgut, H, Narter, F, Tarakci, N, Tekgunduz, KS, Ozkiraz, S, Aydemir, C, Ozdemir, A, Cetinkaya, B, Kazanci, E, Tastekin, A, Calkavur, S, Ozyurt, BM, Demirelli, Y, Asker, HS, Mutlu, B, Uygur, O, Ozkan, H, Armangil, D, Ozlu, F, Mert, MK, Ergin, H, Ozcan, B, Bas, EK, Okulu, E, Acunas, B, Celik, U, Uslu, SI, Mutlu, M, Demir, N, Eroglu, F, Gokmen, Z, Beken, S, Bayraktar, BT, Hakan, N, Kucuktasci, K, Orman, A, Comert, S, Ertugrul, S, Ustun, N, Sahin, O, Terek, D, Kale, Y, Konak, M, Yurttutan, S, Aydemir, O, Zenciroglu, A, Sarici, D, Guzoglu, N, Hamilcikan, S, Gursoy, T, Tuzun, F, Ors, R, Arslan, S, Akdag, A, Memisoglu, A, Yasa, B, Hekimoglu, B, Turan, O, Aylanc, H, Takci, S, Celik, T, Sahin, S, Kilic, I, Kara, C, Tunay, ZO, Celik, G, Gozen, I, Satirtav, G, Polat, N, Oral, AY, Tokgoz, M, Keles, S, Bilgin, B, Ugurbas, SC, Karaca, C, Keskek, NS, Ekinci, DY, Balci, O, Altan, EV, Bakbak, S, Ceylan, NA, Kimyon, S, Alyamac, G, Ture, G, Yildiz, M, Calis, F, Sizmaz, S, Sukgen, E, Cetin, EN, Ozcimen, M, Demir, ST, Atila, H, Ozal, A, Tufaner, G, Yucel, OE, Kola, M, Seven, E, Ozdek, S, Durukan, AH, Kal, A, Celebi, ARC, Koytak, IA, Alacamli, G, Esme, A, Catak, O, Perente, I, Sahin, A, Akcakaya, AA, Kiray, G, Nalcaci, S, Aksoy, U, Bakbak, B, Comez, A, Gursoy, H, Kabatas, EU, Petricli, IS, Yumusak, ME, Kirgiz, A, Uludag, G, Yaman, A, Dadaci, Z, Karatas, A, Celiker, H, Cebeci, Z, Esenulku, MC, Akkoyun, I, Ersan, I, Demir, S, Kadayifcilar, S, Unsal, AIA, and Hocaoglu, M
- Abstract
Background To evaluate the prevalence, risk factors and treatment of retinopathy of prematurity (ROP) in Turkey and to establish screening criteria for this condition. Methods A prospective cohort study (TR-ROP) was performed between 1 April 2016 and 30 April 2017 in 69 neonatal intensive care units (NICUs). Infants with a birth weight (BW)=1500 g or gestational age (GA) 1500 g or GA> 32 weeks with an unstable clinical course were included in the study. Predictors for the development of ROP were determined by logistic regression analyses. Results The TR-ROP study included 6115 infants: 4964 (81%) with a GA 32 weeks. Overall, 27% had any stage of ROP and 6.7% had severe ROP. A lower BW, smaller GA, total days on oxygen, late-onset sepsis, frequency of red blood cell transfusions and relative weight gain were identified as independent risk factors for severe ROP in infants with a BW=1500 g. Of all infants, 414 needed treatment and 395 (95.4%) of the treated infants had a BW
- Published
- 2018
5. Effect of evaporated ethyl pyruvate on reducing salmonella enteritidis in raw chicken meat
- Author
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Cetin, B, primary, Uran, H, additional, and Konak, M, additional
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- 2019
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6. PH—Postharvest Technology: Physical properties of chick pea seeds
- Author
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Konak, M., Çarman, K., and Aydin, C.
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- 2002
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7. Role of subgroup incompatibility in newborn jaundice requiring exchange transfusion [Kan de?işimi gereksinimi olan yenido?an sari{dotless}li{dotless}?i{dotless}nda subgrup uyuşmazli{dotless}?i{dotless}ni{dotless}n rolü]
- Author
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Annagür A., Altunhan H., Konak M., Koç H., Örs R., and Selçuk Üniversitesi
- Subjects
Exchange transfusion ,Subgroup incompatibility ,Newborn jaundice ,Minor blood group incompatibility ,Hyperbilirubinemia - Abstract
We aimed to determine the role of exchange transfusion related complications, treatment, and etiology as well as subgroup incompatibility in patients subject to ET (exchange transfusion) due to newborn jaundice. 82 patients hospitalized due to newborn jaundice and exposed to exchange transfusion between August 2007 and August 2011 were retrospectively studied. Before ET mean total serum bilirubin was 29,2±9,83. The most frequent cause of ET was ABO incompatibility (31%) followed by Rh incompatibility (19%) and subgroup incompatibility (17%), respectively. In 46% of all patients and in 71% of the patients presenting with subgroup incompatibility, direct combs test was detected to be (+). 49% of the patients were administrated with intravenous immunoglobulin. 5 of the patients who were exposed to ET presented with hydrops fetalis. Of these patients 3 had Rh, 1 had ABO while the other had subgroup incompatibility. Although ABO and Rh incompatibility are substantial underlying reasons of severe jaundice requiring exchange transfusion, particularly widespread use of RhoGAM thereby enabling the prior identification and precautions, ET need was reduced compared to previous cases. On the contrary, SGU related severe hemolytic jaundice relatively enhanced, however.
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- 2014
8. Prevalence and Predictors of Vitamin D Insufficiency in Adolescents Living at an Intermediate Altitude
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Konak, M, primary, Alp, H, additional, Orbak, Z, additional, and Özkan, B, additional
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- 2015
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9. 1368 Perinatal Mortality Rate of SelCUK UNiversity Faculty of Medicin in Year of 2008
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Altunhan, H., primary, Annagur, A., additional, Ozdemir, Y., additional, Konak, M., additional, and Ors, R., additional
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- 2012
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10. 1128 Evaluation of Oral Prostaglandin E1 in Management of Ductus Dependent Congenital Heart Disease
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Annagur, A., primary, Altunhan, H., additional, Konak, M., additional, Karaaslan, S., additional, and Ors, R., additional
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- 2012
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11. 1288 Total Oxidant Levels, Total Antioxidant Levels and Paraoxonase Levels in Babies Born to Preeclamptic Mothers
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Altunhan, H., primary, Annagur, A., additional, Konak, M., additional, Kurban, S., additional, Mehmetoglu, I., additional, and Ors, R., additional
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- 2012
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12. 1774 Cause of Respiratory Distress in Neonatal Intensive Care Unit: A Retrospective Evaluation
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Annagur, A., primary, Altunhan, H., additional, Aribas, S., additional, Konak, M., additional, and Ors, R., additional
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- 2012
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13. 1182 Total Oxidative Status, Total Anti-Oxidative Status and Paraoxonase-1 Levels in Neonatal Sepsis
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Annagur, A., primary, Altunhan, H., additional, Konak, M., additional, Kurban, S., additional, and Ors, R., additional
- Published
- 2012
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14. 1367 Neonatal Motality and Mobidity Rates Who Were Admitted to the Neonatal ICU of Konya In Two Years
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Altunhan, H., primary, Annagur, A., additional, Ozdemir, Y., additional, Konak, M., additional, and Ors, R., additional
- Published
- 2012
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15. PH—Postharvest Technology
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Aydin, C., primary, Ö ǧ, H., additional, and Konak, M., additional
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- 2002
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16. PH—Postharvest Technology
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Konak, M., primary, Çarman, K., additional, and Aydin, C., additional
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- 2002
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17. PH—Postharvest Technology: Some Physical Properties of Turkish Mahaleb
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Aydin, C., Ö ǧ, H., and Konak, M.
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- 2002
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18. Quantitative determination of tannic acid in Quercus species by high performance liquid chromatography
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Saltan, F. Z., Seçilmiş Canbay, H., Üvez, A., Konak, M., Elif Ilkay Armutak, and Anadolu Üniversitesi
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Tannic acid ,Tannin ,Oak ,Quercus infectoria subsp. boissieri ,HPLC ,Quercus infectoria subsp. infectoria - Abstract
This study aims to the quantitative analysis of tannic acid in different extracts of Quercus species growing in Turkey. For this purpose, the quantitative analysis of tannic acid was performed in two oak galls (Q.infectoria subsp. infectoria and subsp. boissieri) growing in Turkey by using of High Performance Liquid Chromatography (HPLC) method. Four different solvents were used for extraction procedure. So, tannic acid contents were determined in 96% ethanolic extracts (30.852-81.012 mg/g), 80% ethanolic extracts (43.898-127.683 mg/g), 70% acetone extracts (3.064-67.200 mg/g) and extracts with mixture of diethylether: ethanol: water (0.016-0.112 mg/g) for Quercus infectoria subsp. boissieri and Q. infectoria subsp.infectoria galls, respectively. The most abundant tannic acid has been reported as 127.683 mg/g in the 80% ethanolic extract of Quercus infectoria subsp. infectoria. The limits of detection and quantification were measured as 1.5 ppm and 4.95 ppm, respectively. This is the first study on the quantitative determination of tannic acid for two subspecies of Quercus infectoria (subsp. infectoria and subsp. boissieri) growing in Turkey in literature. © 2019 Society of Pharmaceutical Sciences of Ankara (FABAD). All rights reserved.
19. Dynamic light scattering of particles diffusing within a microscopic cage: Model calculations
- Author
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Koňák, Č., Koňák, M., and Bansil, R.
- Published
- 1991
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20. Effect of kangaroo mother care on cerebral oxygenation, physiological parameters, and comfort levels in late-premature infants: A randomized controlled trial.
- Author
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Tas Arslan F, Akkoyun S, Küçükoğlu S, Kocoglu-Tanyer D, Konak M, and Soylu H
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- Humans, Infant, Newborn, Female, Prospective Studies, Male, Single-Blind Method, Turkey, Spectroscopy, Near-Infrared methods, Heart Rate physiology, Patient Comfort methods, Patient Comfort standards, Patient Comfort statistics & numerical data, Oxygen Saturation physiology, Oxygen metabolism, Kangaroo-Mother Care Method methods, Infant, Premature physiology, Intensive Care Units, Neonatal
- Abstract
Objective: To measure the effects kangaroo mother care (KMC) on the regional cerebral oxygen saturation (rSO
2 ) measured with near-infrared spectroscopy (NIRS) in premature infants and to study the physiological stability and comfort of the infants during such interventions., Design: This was a prospective, single-centered, single-blind, 2-arm, parallel-group randomized controlled trial conducted., Settings: The study was carried out in a tertiary neonatal intensive care unit in Medical Faculty Hospital in Konya/Turkey., Participants: Premature infants born between 24 and 36+6 weeks. Participants were randomly assigned to one of two groups: kangaroo care (n = 20) and control groups (n = 20). The rSO2 , oxygen saturation (%SpO2 ), heart rate (HR), respiratory rate, body temperature, and comfort levels of the infants were evaluated in three stages., Findings: In the 60th min measurement of the intervention group, rSO2 , body temperature, heart rate, respiratory rate, and, comfort level, the comfort level was found to be higher and significant in the 30th and 60th min measurements (p < 0.001). In the intervention group, the rSO2 (p < 0.001), body temperature (p < 0.001), HR (p < 0.001), SpO2 (p < 0.001), respiratory rate (p < 0.001), and comfort levels (p < 0.001) scores with the control group and the group × time interaction was significant., Key Conclusions: KMC moderately increased the rSO2 levels and also created a moderate effect size on the physiological parameters and comfort levels of the newborns, which implicates its short-term benefits for premature infants., Practice Implications: KMC may be beneficial in stabilizing rSO2 and physiological parameters and increasing comfort in premature infants. The trial was registered in ClinicalTrials.gov (identifier: NCT04725435)., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)- Published
- 2024
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21. Early neonatal outcomes of very-low-birth-weight infants in Turkey: A prospective multicenter study of the Turkish Neonatal Society.
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Koc E, Demirel N, Bas AY, Ulubas Isik D, Hirfanoglu IM, Tunc T, Sari FN, Karatekin G, Ozdemir R, Altunhan H, Cetinkaya M, Ozcan B, Ozkiraz S, Calkavur S, Tekgunduz KS, Tastekin A, Ozlu F, Mutlu Ozyurt B, Ozdemir A, Cetinkaya B, Demirelli Y, Koklu E, Celik U, Tarakci N, Armangil D, Okulu E, Narter F, Mutlu B, Mert MK, Bulbul A, Asker HS, Uygur O, Uslu IS, Ertugrul S, Aydemir C, Celik HT, Kucuktasci K, Arslan S, Ergin H, Zenciroglu A, Yurttutan S, Orman A, Tuncer O, Yasa B, Acunas B, Takci S, Gokmen Z, Ozkan H, Comert S, Ustun N, Mutlu M, Bayraktar BT, Bilgin L, Tuzun F, Aydemir O, Gursoy T, Akdag A, Memisoglu A, Can E, Terek D, Beken S, Turan O, Guzoglu N, Ors R, Kale Y, Hekimoglu B, Aylanc H, Eroglu F, Sahin S, Konak M, Sarici D, Kilic I, and Hakan N
- Subjects
- Adult, Birth Weight, Female, Gestational Age, Humans, Infant, Newborn, Intensive Care Units, Neonatal, Male, Morbidity, Pregnancy, Prospective Studies, Turkey epidemiology, Infant, Newborn, Diseases epidemiology, Infant, Very Low Birth Weight, Pregnancy Outcome epidemiology
- Abstract
Objective: To investigate the early neonatal outcomes of very-low-birth-weight (VLBW) infants discharged home from neonatal intensive care units (NICUs) in Turkey., Material and Methods: A prospective cohort study was performed between April 1, 2016 and April 30, 2017. The study included VLBW infants admitted to level III NICUs. Perinatal and neonatal data of all infants born with a birth weight of ≤1500 g were collected for infants who survived., Results: Data from 69 NICUs were obtained. The mean birth weight and gestational age were 1137±245 g and 29±2.4 weeks, respectively. During the study period, 78% of VLBW infants survived to discharge and 48% of survived infants had no major neonatal morbidity. VLBW infants who survived were evaluated in terms of major morbidities: bronchopulmonary dysplasia was detected in 23.7% of infants, necrotizing enterocolitis in 9.1%, blood culture proven late-onset sepsis (LOS) in 21.1%, blood culture negative LOS in 21.3%, severe intraventricular hemorrhage in 5.4% and severe retinopathy of prematurity in 11.1%. Hemodynamically significant patent ductus arteriosus was diagnosed in 24.8% of infants. Antenatal steroids were administered to 42.9% of mothers., Conclusion: The present investigation is the first multicenter study to include epidemiological information on VLBW infants in Turkey. Morbidity rate in VLBW infants is a serious concern and higher than those in developed countries. Implementation of oxygen therapy with appropriate monitoring, better antenatal and neonatal care and control of sepsis may reduce the prevalence of neonatal morbidities. Therefore, monitoring standards of neonatal care and implementing quality improvement projects across the country are essential for improving neonatal outcomes in Turkish NICUs., Competing Interests: The authors have declared that no competing interests exist.
- Published
- 2019
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22. Short-term results of patients with neural tube defects followed-up in the Konya region, Turkey.
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Yorulmaz A and Konak M
- Subjects
- Anencephaly, Congenital Abnormalities etiology, Consanguinity, Encephalocele, Female, Heart Defects, Congenital, Humans, Infant, Newborn, Male, Neural Tube Defects mortality, Neural Tube Defects physiopathology, Pregnancy, Premature Birth, Prognosis, Retrospective Studies, Risk Factors, Turkey epidemiology, Nervous System Malformations etiology, Neural Tube Defects complications
- Abstract
Background: Additional congenital anomalies have often been found in patients with neural tube defect (NTD). We aimed to find out the clinical features, short term prognosis, treatment approaches, and systemic anomalies of NTD patients in the Konya region., Method: A total of 186 newborn babies with NTD were retrospectively included in the study and all were assessed in detail for congenital anomalies and clinical features., Results: When the application month of the patients was examined, it was seen that the most frequent month was July. Of 186 babies, 101(54.3%) had meningomyelocele, 53 (28.5%) had meningocele, 13 (7.0%) had encephalocele, 16 (8.6%) had spina bifida occulta, and 4 (2.1%) had anencephaly. Of these patients, 97 (52.2%) were male and 89 (47.8%) were female. Hydrocephalus was an almost constant finding and was found in 140 (75.3%) patients. 51 (27.4%) patients had congenital heart disease (CHD). The most common CHD was atrial septal defect 22.3%. Orthopedic anomaly was detected in 51 (27.4%) patients, nephrological anomaly was found in 47 (25.3%) of the cases, congenital hypothyroidism was diagnosed in 14 (7.5%) patients with NTD. The mortality rate of patients diagnosed with NTD was 7.5%. The rates of premature delivery and consanguinity between parents were higher in patients with NTD., Conclusions: Our results indicate that at least one congenital anomaly is also present in about two-thirds of newborn babies with NTD, and these anomalies significantly increase their morbidity and mortality. All newborn babies with NTD should be screened for additional congenital anomalies and evaluated with more organized, multidisciplinary methods., (© 2019 Wiley Periodicals, Inc.)
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- 2019
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23. Effects of the storage of breast milk at different temperatures on total antioxidant capacity, total oxidant status, and paraoxonase-1 level.
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Konak M, Minici M, Tarakçı N, Altunhan H, Toker A, and Örs R
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- Adult, Antioxidants metabolism, Aryldialkylphosphatase blood, Biomarkers blood, Breast Milk Expression, Female, Humans, Infant, Infant, Newborn, Infant, Premature, Oxidative Stress, Antioxidants analysis, Aryldialkylphosphatase analysis, Cold Temperature, Cryopreservation methods, Milk, Human chemistry, Oxidants blood
- Abstract
Konak M, Minici M, Tarakçı N, Altunhan H, Toker A, Örs R. Effects of the storage of breast milk at different temperatures on total antioxidant capacity, total oxidant status, and paraoxonase-1 level. Turk J Pediatr 2019; 61: 1-6. Breast milk is a well-balanced ideal nutritional source with high bioavailability for infants. As being a fresh, biological and dynamic product, changes in the breast milk during these storage periods have been the subject of ongoing research. This study aims to evaluate total antioxidant capacity (TAC), total oxidant status (TOS), and paraoxonase-1 (PON-1) levels of fresh and freezestored breast milk. Ten cc of breast milk was obtained from the mothers as the days between 10 and 15 in the morning within a 1-hour period. TAC, TOS, and PON-1 levels were evaluated in the fresh breast milk. Collected breast milk samples were divided into two groups for storage at -20°C or -80°C. Stored samples were tested for TAC, TOS, and PON-1 levels after 72 hours. The highest TAC level was detected in fresh breast milk (p < 0.05). The TOS levels of fresh breast milk showed a statistically significant reduction in rate after storage. The TOS levels at -20°C and -80°C were significantly lower at -80°C (p < 0.05). Our study results show that oxidant and antioxidant activities are at the maximum level in the fresh breast milk. In terms of antioxidant status the effect of freezing temperatures hasn`t been determined. We conclude that it is more convenient to store the breast milk at -80°C than to store at -20°C in terms of preserving the storage TOS level.
- Published
- 2019
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24. Total antioxidant, total oxidant and serum paraoxonase levels according to lipid administration method in parenterally fed premature infants.
- Author
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Konak M, Tarakci N, Altunhan H, Annagür A, Toker A, and Örs R
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- Adult, Female, Humans, Infant, Newborn, Male, Oxidative Stress, Young Adult, Antioxidants metabolism, Aryldialkylphosphatase blood, Infant, Premature blood, Lipids administration & dosage, Parenteral Nutrition methods
- Abstract
Objective: The aim of our study was to determine whether lipid solutions delivered separately or in mixture with total parenteral nutrition (TPN) solutions effect the balance between oxidant and antioxidant levels in premature infants., Methods: A total of 60 preterm newborns who were delivered at their 30-34 gestational weeks and received TPN were included in the study. Premature newborns were randomized into two groups based on the delivery method of the lipid solution, separately (Group 1) or in mixture with TPN solutions (Group 2). Total antioxidant status (TAS), total oxidant status (TOS) and paraoxonase (PON-1) levels were analyzed in both blood samples, and oxidative stress index (OSI) was also calculated., Results: Thirty cases from both groups were included in the study. Statistically significant decrease in the level of TAS and increase in the level of PON-1 were detected at 72 h of TPN therapy in both groups (p < 0.05). Statistically significant decrease in both TOS and OSI levels were observed in Group 2 (p < 0.05). In association with these findings, any statistically significant intergroup difference was not detected in both parameters regarding oxidant balance (p > 0.05)., Conclusion: Our study showed that according to lipid administration method any difference for oxidant-antioxidant balance was not detected.
- Published
- 2017
- Full Text
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25. The protective effects of different treatments on rat salivary glands after radiotherapy.
- Author
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Konak M, Cincik H, Erkul E, Kucukodaci Z, Gungor A, Ozdemir S, Cekin E, Arisan V, Mutluoglu M, and Salihoglu M
- Subjects
- Animals, Male, Parotid Gland radiation effects, Radiation Dosage, Radiotherapy adverse effects, Random Allocation, Rats, Rats, Wistar, Acetylcysteine therapeutic use, Dexamethasone therapeutic use, Glucocorticoids therapeutic use, Hyperbaric Oxygenation, Radiation Injuries, Experimental prevention & control, Radiation-Protective Agents therapeutic use, Salivary Glands radiation effects
- Abstract
This study was aimed to evaluate the efficacy of treatment modalities for minimizing salivary gland damage caused by radiotherapy. Forty rats were divided into five groups. Group 1 had no irradiation or any treatment. Group 2 underwent only 15 Gy single dose radiotherapy. N-acetylcysteine, dexamethasone, hyperbaric oxygen treatment were given, respectively to the group 3, 4 and 5 for 5 days. 15 Gy single dose radiotherapy was applied to the group 3, 4 and 5 on the second day. Pyknosis, lysis, and vacuolization were examined in ductal cells and pyknosis, lysis, vacuolization, inflammation and collective duct damage in acinar cells. Dexamethasone and hyperbaric oxygen did not prove to have a positive effect on acinar and ductal cell. N-acetylcysteine-applied group had statistically significantly lower amount of damage. We determined that the decrease of ductal and acinar cell damage in parotid glands of N-acetylcysteine-applied rats was more distinct and statistically.
- Published
- 2016
- Full Text
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26. Fully automated simultaneous umbilical arteriovenous exchange transfusion in term and late preterm infants with neonatal hyperbilirubinemia.
- Author
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Altunhan H, Annagür A, Tarakçi N, Konak M, Ertuğrul S, and Örs R
- Subjects
- Female, Humans, Infant, Newborn, Infant, Premature, Male, Phototherapy statistics & numerical data, Retrospective Studies, Umbilical Arteries, Umbilical Veins, Exchange Transfusion, Whole Blood methods, Hyperbilirubinemia, Neonatal therapy, Jaundice, Neonatal therapy
- Abstract
Objectives: The purpose of this study was to compare the efficacy and safety of two different catheterization techniques of exchange transfusion (ET) used in the therapy of newborn jaundice: fully automated two-way ET technique and the classical one-way ET., Patients and Methods: The study included babies at gestational age of >34 weeks. In total, 107 ETs were performed on 86 babies. Totally, the umbilical vein (UV) group included 54 babies having undergone 69 ETs and the UV/UA group included 32 babies having undergone 38 ETs., Results: The declines in bilirubin levels right after ET (p = 0.018) and 8 h after ET (p = 0.014) were higher in the fully automated UV/UA technique than in the classical UV technique. Furthermore, the duration of intensive phototherapy following ET was shorter in the UV/UA method than in the UV method (p = 0.003). There was no difference between the two methods in terms of ET-associated complications (p = 0.927)., Conclusions: In neonatal hyperbilirubinemia, ET with fully automated UV/UA technique is more efficient than the classical ET technique, causing no additional side-effects. It is also more physiological than the classical technique, since it minimizes the fluctuations in the blood volume and intravascular pressure during ET.
- Published
- 2016
- Full Text
- View/download PDF
27. Total antioxidant and total oxidant states, and serum paraoxonase-1 in neonatal sepsis.
- Author
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Annagür A, Örs R, Altunhan H, Kurban S, Ertuğrul S, Konak M, Uygun SS, Pekcan S, Erbay E, and Mehmetoğlu İ
- Subjects
- Biomarkers blood, Female, Humans, Infant, Newborn, Male, Retrospective Studies, Antioxidants metabolism, Aryldialkylphosphatase blood, Neonatal Sepsis blood, Oxidants blood, Oxidative Stress
- Abstract
Background: Paraoxonase-1 (PON-1) is an enzyme with a glycoprotein structure that depends on calcium and which is located in serum high-density lipoprotein (HDL). The aim of this study was to evaluate PON-1, and oxidant/antioxidant state, before and after treatment for neonatal sepsis, and to determine the usability of PON-1 in neonatal sepsis treatment., Methods: A total of 35 neonatal sepsis patients and 35 healthy controls were included in the study. Activity of PON-1, total oxidant state (TOS) and total antioxidant state (TAS) were measured and oxidative stress index (OSI) was calculated., Results: In the neonatal sepsis patients, pre-treatment TAS, TOS and OSI were significantly higher than the post-treatment levels (P < 0.0001, P < 0.0001 and P < 0.0001, respectively), and PON-1 was significantly lower (P < 0.0001). Similarly, pre-treatment TAS, TOS and OSI in the sepsis group were also significantly higher than in the control group (P < 0.0001, P < 0.0001 and P < 0.0001, respectively) and PON-1 was significantly lower (P < 0.0001). Post-treatment TAS in the sepsis group was significantly higher than in the control group (P = 0.009), whereas post-treatment TOS, OSI and PON-1 in the sepsis group were not significantly different to the control group (P = 0.078, P = 0.597 and P = 0.086, respectively)., Conclusion: Low serum PON-1 was found in neonatal sepsis. Serum PON-1 is thought to be a useful biomarker to evaluate the effectiveness of treatment and recovery in neonatal sepsis., (© 2014 Japan Pediatric Society.)
- Published
- 2015
- Full Text
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28. Birth weight and gestational age in newborns exposed to maternal obsessive-compulsive disorder.
- Author
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Uguz F, Yuksel G, Karsidag C, Guncu H, and Konak M
- Subjects
- Adult, Case-Control Studies, Child of Impaired Parents, Cross-Sectional Studies, Family, Female, Humans, Infant, Newborn, Maternal Age, Mental Disorders, Obsessive-Compulsive Disorder psychology, Pregnancy, Prenatal Exposure Delayed Effects psychology, Birth Weight physiology, Gestational Age, Obsessive-Compulsive Disorder physiopathology, Pregnancy Complications psychology, Prenatal Exposure Delayed Effects physiopathology
- Abstract
We examined the impact of maternal obsessive-compulsive disorder (OCD) on gestational age and birth weight of infants. The sample included 63 mothers (28 patient and 35 controls). OCD and other psychiatric diagnoses were determined with a structured clinical interview. Birth weight and gestational age were lower in the newborns exposed to maternal OCD compared to ones who were not exposed. The results suggest that maternal OCD may negatively affect fetal weight growth and gestational duration., (Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.)
- Published
- 2015
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29. Successful treatment of atrial flutter with propafenone and synchronized cardioversion in a newborn.
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Konak M, Alp H, Tarakçı N, Baysal T, and Ors R
- Subjects
- Humans, Infant, Newborn, Atrial Flutter therapy, Electric Countershock methods, Propafenone therapeutic use
- Published
- 2014
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30. Total oxidant, antioxidant, and paraoxonase levels in babies born to pre-eclamptic mothers.
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Altunhan H, Annagür A, Kurban S, Ertuğrul S, Konak M, and Örs R
- Subjects
- Child Development, Female, Fetal Blood, Humans, Infant, Newborn, Male, Oxidative Stress, Pregnancy, Prospective Studies, Severity of Illness Index, Antioxidants analysis, Aryldialkylphosphatase blood, Oxidants blood, Pre-Eclampsia physiopathology
- Abstract
Aim: The aim of this study was to investigate the oxidant-antioxidant status in babies born to pre-eclamptic mothers (BBPM)., Material and Methods: The paraoxonase (PON)-1, total antioxidant status (TAS), and total oxidant status (TOS) levels were measured in the cord blood and venous blood (7th day) of BBPM (n = 31) and babies born to normotensive mothers (n = 25)., Results: The PON-1 and TOS levels in the cord blood and venous blood on the 7th day were not significantly different between the two groups; however, the cord blood TAS levels were higher in BBPM (P = 0.001), and the TAS levels in the venous blood were higher in the control group (P = 0.021). Furthermore, the cord blood PON-1 levels of babies born to severely pre-eclamptic mothers (n = 18) were higher than those of babies born to moderately pre-eclamptic mothers (n = 13) (P = 0.042). There were no differences in the cord blood TAS and TOS levels and venous blood PON-1, TAS, and TOS levels between babies born to severely and moderately pre-eclamptic mothers., Conclusion: The increased TAS levels found in the cord blood of BBPM indicate that the fetus is protected against oxidative damage caused by increased oxidative stress in the mother. To the best of our knowledge, this is the first study in the published work investigating PON-1 levels in BBPM., (© 2013 The Authors. Journal of Obstetrics and Gynaecology Research © 2013 Japan Society of Obstetrics and Gynecology.)
- Published
- 2013
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31. The incidence of congenital anomalies associated with cleft palate/cleft lip and palate in neonates in the Konya region, Turkey.
- Author
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Altunhan H, Annagür A, Konak M, Ertuğrul S, Ors R, and Koç H
- Subjects
- Bone and Bones abnormalities, Chromosome Aberrations statistics & numerical data, Consanguinity, Female, Fetal Growth Retardation epidemiology, Head abnormalities, Heart Defects, Congenital epidemiology, Heart Septal Defects, Atrial epidemiology, Humans, Incidence, Infant Mortality, Infant, Newborn, Male, Neck abnormalities, Nervous System Malformations epidemiology, Pregnancy, Premature Birth epidemiology, Prospective Studies, Respiratory Distress Syndrome, Newborn epidemiology, Trisomy, Turkey epidemiology, Urogenital Abnormalities epidemiology, Cleft Lip epidemiology, Cleft Palate epidemiology, Congenital Abnormalities epidemiology
- Abstract
Additional congenital anomalies have often been found in patients with orofacial clefts. We wanted to find out the incidence and type of congenital malformations that may accompany cleft palate (CP) and cleft lip and palate (CLP) in babies born in the Konya region. A total of 121 newborn babies with CP or CLP were prospectively included in the study, and all were assessed in detail for congenital anomalies. Of 121 babies, 86 (71%) had CLP and 35 (29%) had CP. There was at least one congenital malformation in 80 (66%) of the cases. Additional congenital malformations were seen in 26 (74%) of the 35 with isolated CP, and 54 (63%) in the 86 patients with CLP (p<0.05). The most common congenital malformation was congenital heart disease, followed by head and neck anomalies. The most common congenital heart disease was atrial septal defect. A serious chromosomal anomaly was found in 18/121 patients with CP or CLP (15%). Of the 80 babies in whom congenital malformations were found, 31 (39%) had dysmorphic features. While 21 (68%) of dysmorphic cases had isolated CP, 10 (32%) had CLP (p<0.05). The rates of premature delivery, intrauterine growth retardation, and consanguinity between parents were higher in patients with CP or CLP. The neonatal mortality was 20% (n=24). Our results indicate that at least one congenital anomaly is also present in about two-thirds of newborn babies with CP and CLP, and these anomalies significantly increase their morbidity and mortality. All newborn babies with CP and CLP should be screened for additional congenital anomalies, particularly of the cardiovascular system., (Copyright © 2011 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2012
- Full Text
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32. Successful use of topical "Ankaferd Blood Stopper" for repetitive bleedings in an infant with infantile hemangioma.
- Author
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Annagür A, Altunhan H, Konak M, and Ors R
- Abstract
Infantile hemangioma (IH) is the most common vascular tumor of childhood. A major feature of this tumor is rapid growth during a proliferation phase in the first year of life, followed by contraction through a slow involution phase. Several complications may emerge during this course. Bleeding at the site of the lesion and infection are the most common complications. 'Ankaferd Blood Stopper' (ABS) is a hemostatic agent produced as a mixture of five separate plant extracts. Provision of hemostasis by ABS is independent from coagulation factors and the standard coagulation cascade. Furthermore, ABS has an antimicrobial effect. In this article, we have presented a seven-year-old infant with IH on the lower lip who had been admitted with the symptoms of frequent bleedings and infection, and who was successfully treated with topical ABS in terms of control of bleeding and infection. To the best of our knowledge, this is the first reported case of IH that has been treated with ABS for bleeding.
- Published
- 2012
33. Anogenital distance in Turkish newborns.
- Author
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Özkan B, Konak B, Cayır A, and Konak M
- Subjects
- Female, Humans, Male, Reference Values, Statistics, Nonparametric, Turkey, Genitalia, Female anatomy & histology, Genitalia, Male anatomy & histology, Infant, Newborn
- Abstract
Objective: Anogenital distances are considered to be a sensitive indicator of external genitalia exposure to factors such as anti-androgens, and/or endocrine distruptors during the prenatal period. Exposure to such factors can lead to changes in the anogenital measurements (AGM) of newborn infants. These measurements can be used to predict masculinization of the external genitalia in healthy newborns. The goal of this study was to determine normal values for AGM in Turkish newborns of both genders., Methods: One hundred fifteen female and 135 male term newborns with no congenital defects were included in this study. A well-trained observer measured the anogenital distance by using a sliding Caliper graduated in millimeters. Anogenital distance was measured from the center of the anus to the posterior convergence of the fourchette in females and from the center of the anus to the junction of the smooth perineal skin with the base of the scrotum in males., Results: Anogenital distance in males and females was 23±0.6 mm and 10.3±0.2 mm, respectively. There were significant differences in anogenital distance values between male and female newborns (p<0.05)., Conclusion: The findings of this study provide data that can be used as reference standards with regard to AGM of the posterior genital structures in Turkish male and female newborns. These data will also serve in postnatal evaluations to determine the effects of prenatal exposures to factors affecting development of genitalia.
- Published
- 2011
- Full Text
- View/download PDF
34. Hartnup disease masked by kwashiorkor.
- Author
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Orbak Z, Ertekin V, Selimoglu A, Yilmaz N, Tan H, and Konak M
- Subjects
- Acrodermatitis complications, Amino Acids, Neutral urine, Buttocks pathology, Diagnosis, Differential, Fatal Outcome, Female, Hartnup Disease urine, Humans, Indican urine, Infant, Kwashiorkor urine, Perineum pathology, Turkey, Hartnup Disease complications, Hartnup Disease diagnosis, Kwashiorkor complications
- Abstract
This report describes an 11-month old girl with Hartnup disease presenting with kwashiorkor and acrodermatitis enteropathica-like skin lesions but free of other clinical findings. This case with kwashiorkor had acrodermatitis enteropathica-like desquamative skin eruption. Since zinc level was in the normal range, investigation for a metabolic disorder was considered, and Hartnup disease was diagnosed.
- Published
- 2010
- Full Text
- View/download PDF
35. Prevalence of celiac disease in a sample of Turkish children with epilepsy.
- Author
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Ertekin V, Selimoğlu MA, Tan H, and Konak M
- Subjects
- Adolescent, Child, Child, Preschool, Female, Humans, Male, Prevalence, Turkey epidemiology, Celiac Disease complications, Celiac Disease epidemiology, Epilepsy complications, Epilepsy epidemiology
- Published
- 2010
- Full Text
- View/download PDF
36. Association of hepatitis a and acute pancreatitis presenting as acute abdomen.
- Author
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Ertekin V, Selimoglu MA, Konak M, and Orbak Z
- Subjects
- Abdomen, Acute diagnosis, Acute Disease, Child, Preschool, Female, Hepatitis A diagnosis, Humans, Pancreatitis diagnosis, Abdomen, Acute virology, Hepatitis A complications, Pancreatitis virology
- Published
- 2005
- Full Text
- View/download PDF
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