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929 results on '"Kondoh, Yasuhiro"'

1. A prospective cohort study of periostin as a serum biomarker in patients with idiopathic pulmonary fibrosis treated with nintedanib

Author

Okamoto, Masaki, Fujimoto, Kiminori, Johkoh, Takeshi, Kawaguchi, Atsushi, Mukae, Hiroshi, Sakamoto, Noriho, Ogura, Takashi, Ikeda, Satoshi, Kondoh, Yasuhiro, Yamano, Yasuhiko, Komiya, Kosaku, Umeki, Kenji, Nishikiori, Hirotaka, Tanino, Yoshinori, Tsuda, Toru, Arai, Naoki, Komatsu, Masamichi, Sakamoto, Susumu, Yatera, Kazuhiro, Inoue, Yoshikazu, Miyazaki, Yasunari, Hashimoto, Seishu, Shimizu, Yasuo, Hozumi, Hironao, Ohnishi, Hiroshi, Handa, Tomohiro, Hattori, Noboru, Kishaba, Tomoo, Kato, Motoyasu, Inomata, Minoru, Ishii, Hiroshi, Hamada, Naoki, Konno, Satoshi, Zaizen, Yoshiaki, Azuma, Arata, Suda, Takafumi, Izuhara, Kenji, and Hoshino, Tomoaki

Published
2023
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2. Cohort study to evaluate prognostic factors in idiopathic pulmonary fibrosis patients introduced to oxygen therapy

Author

Kataoka, Kensuke, Oda, Keishi, Takizawa, Hajime, Ogura, Takashi, Miyamoto, Atsushi, Inoue, Yoshikazu, Akagawa, Shinobu, Hashimoto, Seishu, Kishaba, Tomoo, Sakamoto, Koji, Hamada, Naoki, Kuwano, Kazuyoshi, Nakayama, Masayuki, Ebina, Masahito, Enomoto, Noriyuki, Miyazaki, Yasunari, Atsumi, Kenichiro, Izumi, Shinyu, Tanino, Yoshinori, Ishii, Hiroshi, Ohnishi, Hiroshi, Suda, Takafumi, and Kondoh, Yasuhiro

Published
2023
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3. Clinical efficacy and safety of multipotent adult progenitor cells (invimestrocel) for acute respiratory distress syndrome (ARDS) caused by pneumonia: a randomized, open-label, standard therapy–controlled, phase 2 multicenter study (ONE-BRIDGE)

Author

Ichikado, Kazuya, Kotani, Toru, Kondoh, Yasuhiro, Imanaka, Hideaki, Johkoh, Takeshi, Fujimoto, Kiminori, Nunomiya, Shin, Kawayama, Tomotaka, Sawada, Masanori, Jenkins, Eric, Tasaka, Sadatomo, and Hashimoto, Satoru

Published
2023
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6. Pulmonary function and chest CT abnormalities 3 months after discharge from COVID-19, 2020–2021: A nation-wide multicenter prospective cohort study from the Japanese respiratory society

Author

Kamata, Hirofumi, Takamatsu, Kazufumi, Fukunaga, Koichi, Chubachi, Shotaro, Nakagawara, Kensuke, Namkoong, Ho, Terai, Hideki, Tanaka, Katsushi, Sato, Susumu, Hagiwara, Eri, Takei, Reoto, Kondoh, Yasuhiro, Takazono, Takahiro, Hashimoto, Midori, Tasaka, Sadatomo, Ohrui, Takashi, Tanino, Yoshinori, Mineshita, Masamichi, Komase, Yuko, Miyazaki, Kazuhito, Nishikawa, Masanori, Ando, Akira, Kita, Hideo, Ichihara, Eiki, Ohshimo, Shinichiro, Murata, Yoriyuki, Ishida, Masayuki, Kobayashi, Seiichi, Uchida, Takahiro, Tateno, Hiroki, Ikari, Jun, Terashima, Takeshi, Kozu, Yutaka, Tateishi, Tomoya, Shinkai, Masaharu, Sagara, Hironori, To, Yasuo, Ito, Yoko, Yamamoto, Masaki, Yamamoto, Yoshihiro, Kita, Toshiyuki, Ito, Yutaka, Tomii, Keisuke, Fujita, Yukio, Funaki, Yoshihiro, Yatera, Kazuhiro, Yamasue, Mari, Komiya, Kosaku, Kozawa, Satoko, Manabe, Hideaki, Hozumi, Hironao, Horiguchi, Tomoya, Kitajima, Takamasa, Nakano, Yasushi, Nagaoka, Tetsutaro, Hojo, Masayuki, Ebihara, Akinori, Kobayashi, Masayoshi, Takayama, Koji, Jinta, Torahiko, Sawai, Toyomitsu, Fukuda, Yuichi, Kaneko, Takeshi, Chin, Kazuo, Ogura, Takashi, Mukae, Hiroshi, Ishii, Makoto, and Yokoyama, Akihito

Published
2024
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10. Validation of a computed tomography diagnostic model for differentiating fibrotic hypersensitivity pneumonitis from idiopathic pulmonary fibrosis

Author

Sumikawa, Hiromitsu, Komiya, Kosaku, Egashira, Ryoko, Tominaga, Junya, Ueno, Midori, Fukuda, Taiki, Yamada, Daisuke, Takei, Reoto, Kataoka, Kensuke, Kimura, Tomoki, Kondoh, Yasuhiro, Ejima, Masaru, Shimamura, Takashi, Tateishi, Tomoya, Tomioka, Hiromi, Miyazaki, Yasunari, Suda, Takafumi, and Johkoh, Takeshi

Published
2024
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11. Pulmonary Hypertension With Interstitial Pneumonia: Initial Treatment Effectiveness and Severity in a Japan Registry

Author

Tanabe, Nobuhiro, Kumamaru, Hiraku, Tamura, Yuichi, Kondoh, Yasuhiro, Nakayama, Kazuhiko, Kinukawa, Naoko, Kimura, Tomoki, Nishiyama, Osamu, Tsujino, Ichizo, Shigeta, Ayako, Morio, Yoshiteru, Inoue, Yoshikazu, Kuraishi, Hiroshi, Hirata, Ken-ichi, Tanaka, Kensuke, Kuwana, Masataka, Nagaoka, Tetsutaro, Handa, Tomohiro, Sugimura, Koichiro, Sakamaki, Fumio, Naito, Akira, Taniguchi, Yu, Matsubara, Hiromi, Hanaoka, Masayuki, Inami, Takumi, Hayama, Naoki, Nishimura, Yoshihiro, Kimura, Hiroshi, Miyata, Hiroaki, and Tatsumi, Koichiro

Published
2024
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17. Management of Acute Exacerbation of Idiopathic Pulmonary Fibrosis in Specialised and Non-specialised ILD Centres Around the World.

Author

Polke, Markus, Kondoh, Yasuhiro, Wijsenbeek, Marlies, Cottin, Vincent, Walsh, Simon, Collard, Harold, Chaudhuri, Nazia, Avdeev, Sergey, Behr, Jürgen, Calligaro, Gregory, Corte, Tamera, Flaherty, Kevin, Funke-Chambour, Manuela, Kolb, Martin, Krisam, Johannes, Maher, Toby, Molina Molina, Maria, Morais, Antonio, Moor, Catharina, Morisset, Julie, Pereira, Carlos, Quadrelli, Silvia, Selman, Moises, Tzouvelekis, Argyrios, Valenzuela, Claudia, Vancheri, Carlo, Vicens-Zygmunt, Vanesa, Wälscher, Julia, Wuyts, Wim, Bendstrup, Elisabeth, and Kreuter, Michael

Subjects
acute exacerbation, idiopathic pulmonary fibrosis, non-specialised ILD centres, pulmonologists, questionnaire, specialised ILD centres
Abstract

Background: Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is a severe complication associated with a high mortality. However, evidence and guidance on management is sparse. The aim of this international survey was to assess differences in prevention, diagnostic and treatment strategies for AE-IPF in specialised and non-specialised ILD centres worldwide. Material and Methods: Pulmonologists working in specialised and non-specialised ILD centres were invited to participate in a survey designed by an international expert panel. Responses were evaluated in respect to the physicians institutions. Results: Three hundred and two (65%) of the respondents worked in a specialised ILD centre, 134 (29%) in a non-specialised pulmonology centre. Similarities were frequent with regards to diagnostic methods including radiology and screening for infection, treatment with corticosteroids, use of high-flow oxygen and non-invasive ventilation in critical ill patients and palliative strategies. However, differences were significant in terms of the use of KL-6 and pathogen testing in urine, treatments with cyclosporine and recombinant thrombomodulin, extracorporeal membrane oxygenation in critical ill patients as well as antacid medication and anaesthesia measures as preventive methods. Conclusion: Despite the absence of recommendations, approaches to the prevention, diagnosis and treatment of AE-IPF are comparable in specialised and non-specialised ILD centres, yet certain differences in the managements of AE-IPF exist. Clinical trials and guidelines are needed to improve patient care and prognosis in AE-IPF.

Published
2021

19. A Systematically Derived Exposure Assessment Instrument for Chronic Hypersensitivity Pneumonitis

Author

Barnes, Hayley, Morisset, Julie, Molyneaux, Philip, Westall, Glen, Glaspole, Ian, Collard, Harold R, Collaborators, CHP Exposure Assessment, Antoniou, Katerina M, Barber, Christopher M, Behr, Jürgen, Bonella, Francesco, Corte, Tamera, Costabel, Ulrich, Cottin, Vincent, Crestani, Bruno, Dalphin, Jean-Charles, Flaherty, Kevin R, Goh, Nicole, Johannson, Kerri A, Kondoh, Yasuhiro, Lederer, David, Lee, Joyce, Maher, Toby M, Martinez, Fernando J, Morell, Ferran, Noth, Imre, Raghu, Ganesh, Renzoni, Elisabetta, Richeldi, Luca, Ryerson, Christopher J, Ryu, Jay H, Salisbury, Margaret L, Singh, Sheetu, Selman, Moises, Strek, Mary E, Tarlo, Susan M, Tomassetti, Sara, Vancheri, Carlo, Vasakova, Martina, Wolters, Paul, and Wells, Athol

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Management of diseases and conditions, 7.3 Management and decision making, Alveolitis, Extrinsic Allergic, Chronic Disease, Consensus, Humans, Lung, Tomography, X-Ray Computed, extrinsic allergic alveolitis, hypersensitivity pneumonitis, interstitial lung diseases, CHP Exposure Assessment Collaborators, Respiratory System, Cardiovascular medicine and haematology, Clinical sciences
Abstract

BackgroundChronic hypersensitivity pneumonitis (CHP) is an immune-mediated interstitial lung disease (ILD) caused by inhalational exposure to environmental antigens, resulting in parenchymal fibrosis. By definition, a diagnosis of CHP assumes a history of antigen exposure, but only half of all patients eventually diagnosed with CHP will have a causative antigen identified. Individual clinician variation in eliciting a history of antigen exposure may affect the frequency and confidence of CHP diagnosis.MethodsA list of potential causative exposures were derived from a systematic review of the literature. A Delphi method was applied to an international panel of ILD experts to obtain consensus regarding technique for the elicitation of exposure to antigens relevant to a diagnosis of CHP. The consensus threshold was set at 80% agreement, and median ≤ 2, interquartile range = 0 on a 5-point Likert scale (1, strongly agree; 2, tend to agree; 3, neither agree nor disagree; 4, disagree; 5, strongly disagree).ResultsIn two rounds, 36/40 experts participated. Experts agreed on 18 exposure items to ask every patient with suspected CHP. Themes included CHP inducing exposures, features that contribute to an exposure's relevance, and quantification of a relevant exposure. Based on the results from the literature review and Delphi process, a CHP exposure assessment instrument was derived. Using cognitive interviews, the instrument was revised by patients with ILD for readability and usability.ConclusionsThis Delphi survey provides items that ILD experts agree are important to ask in all patients presenting with suspected CHP and provides basis for a systematically derived CHP exposure assessment instrument. Clinical utility of this exposure assessment instrument may be affected by different local prevalence patterns of exposures. Ongoing research is required to clinically validate these items and consider their impact in more geographically diverse settings.

Published
2020

21. Home monitoring in interstitial lung diseases

Author

Wijsenbeek, Marlies S, Moor, Catharina C, Johannson, Kerri A, Jackson, Peter D, Khor, Yet H, Kondoh, Yasuhiro, Rajan, Sujeet K, Tabaj, Gabriela C, Varela, Brenda E, van der Wal, Pieter, van Zyl-Smit, Richard N, Kreuter, Michael, and Maher, Toby M

Published
2023
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23. Idiopathic Pulmonary Fibrosis Incidentally Detected by CT Scan as Interstitial Lung Abnormalities

Author

Bando, Tomohiro, primary, Takei, Reoto, additional, Fukihara, Jun, additional, Sasano, Hajime, additional, Yamano, Yasuhiko, additional, Yokoyama, Toshiki, additional, Matsuda, Toshiaki, additional, Kataoka, Kensuke, additional, Kimura, Tomoki, additional, Fukuoka, Junya, additional, Hatabu, Hiroto, additional, Johkoh, Takeshi, additional, and Kondoh, Yasuhiro, additional

Published
2024
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26. Sensitivity of transbronchial lung cryobiopsy in the diagnosis of different interstitial lung diseases

Author

Zaizen, Yoshiaki, Tachibana, Yuri, Ozasa, Mutsumi, Yamano, Yasuhiko, Takei, Reoto, Kohashi, Yasuo, Kataoka, Kensuke, Saito, Yuji, Tabata, Kazuhiro, Okamoto, Masaki, Tominaga, Masaki, Fujimoto, Kiminori, Sakamoto, Noriho, Ashizawa, Kazuto, Mukae, Hiroshi, Bychkov, Andrey, Johkoh, Takeshi, Hoshino, Tomoaki, Kondoh, Yasuhiro, and Fukuoka, Junya

Published
2022
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27. Inhibition of lung microbiota-derived proapoptotic peptides ameliorates acute exacerbation of pulmonary fibrosis

Author

D’Alessandro-Gabazza, Corina N., Yasuma, Taro, Kobayashi, Tetsu, Toda, Masaaki, Abdel-Hamid, Ahmed M., Fujimoto, Hajime, Hataji, Osamu, Nakahara, Hiroki, Takeshita, Atsuro, Nishihama, Kota, Okano, Tomohito, Saiki, Haruko, Okano, Yuko, Tomaru, Atsushi, Fridman D’Alessandro, Valeria, Shiraishi, Miyako, Mizoguchi, Akira, Ono, Ryoichi, Ohtsuka, Junpei, Fukumura, Masayuki, Nosaka, Tetsuya, Mi, Xuenan, Shukla, Diwakar, Kataoka, Kensuke, Kondoh, Yasuhiro, Hirose, Masaki, Arai, Toru, Inoue, Yoshikazu, Yano, Yutaka, Mackie, Roderick I., Cann, Isaac, and Gabazza, Esteban C.

Published
2022
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30. Phase II Clinical Trial of Combination Therapy with Favipiravir and Methylprednisolone for COVID-19 with Non-Critical Respiratory Failure

Author

Shindo, Yuichiro, Kondoh, Yasuhiro, Kada, Akiko, Doi, Yohei, Tomii, Keisuke, Mukae, Hiroshi, Murata, Naohiko, Imai, Ryosuke, Okamoto, Masaki, Yamano, Yasuhiko, Miyazaki, Yasunari, Shinoda, Masahiro, Aso, Hiromichi, Izumi, Shinyu, Ishii, Haruyuki, Ito, Ryota, Saito, Akiko M., Saito, Toshiki I., and Hasegawa, Yoshinori

Published
2021
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32. Presence of focal usual interstitial pneumonia is a key prognostic factor in progressive pulmonary fibrosis.

Author

Tsushima, Yukio, Okoshi, Ethan N, Ishijima, Sousuke, Bychkov, Andrey, Lami, Kris, Morimoto, Shimpei, Yamano, Yasuhiko, Kataoka, Kensuke, Johkoh, Takeshi, Kondoh, Yasuhiro, and Fukuoka, Junya

Subjects
IDIOPATHIC pulmonary fibrosis, PULMONARY fibrosis, LUNGS, INTERSTITIAL lung diseases, PROGNOSIS, FIBROSIS
Abstract

Aims: Progressive pulmonary fibrosis (PPF) is a newly recognised clinical phenotype of interstitial lung diseases in the 2022 interstitial pulmonary fibrosis (IPF) guidelines. This category is based entirely on clinical and radiological factors, and the background histopathology is unknown. Our objective was to investigate the histopathological characteristics of PPF and to examine the correlation between usual interstitial pneumonia (UIP) and prognosis in this new disease type. We hypothesised that the presence of UIP‐like fibrosis predicts patients' survival in PPF cases. Methods and results: We selected 201 cases fulfilling the clinical criteria of PPF from case archives. Cases diagnosed as IPF by a multidisciplinary team were excluded. Whole slide images were evaluated by three pathologists who were blinded to clinical and radiological data. We measured areas of UIP‐like fibrosis and calculated what percentage of the total lesion area they occupied. The presence of focal UIP‐like fibrosis amounting to 10% or more of the lesion area was seen in 148 (73.6%), 168 (83.6%) and 165 (82.1%) cases for each pathologist, respectively. Agreement of the recognition of UIP‐like fibrosis in PPF cases was above κ = 0.6 between all pairs. Survival analysis showed that the presence of focal UIP‐like fibrosis correlated with worsened survival under all parameters tested (P < 0.001). Conclusions: The presence of UIP‐like fibrosis is a core pathological feature of clinical PPF, and its presence within diseased areas is associated with poorer prognosis. This study highlights the importance of considering the presence of focal UIP‐like fibrosis in the evaluation and management of PPF. [ABSTRACT FROM AUTHOR]

Published
2024
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34. Identification of Diagnostic Criteria for Chronic Hypersensitivity Pneumonitis. An International Modified Delphi Survey

Author

Morisset, Julie, Johannson, Kerri A, Jones, Kirk D, Wolters, Paul J, Collard, Harold R, Walsh, Simon LF, Ley, Brett, Antoniou, Katerina M, Assayag, Deborah, Behr, Juergen, Bonella, Francesco, Brown, Kevin K, Collins, Bridget F, Cormier, Yvon, Corte, Tamera J, Costabel, Ulrich, Danoff, Sonye K, de Boer, Kaïssa, Fernandez Perez, Evans R, Flaherty, Kevin R, Goh, Nicole SL, Glaspole, Ian, Jones, Mark G, Kondoh, Yasuhiro, Kreuter, Michael, Lacasse, Yves, Lancaster, Lisa H, Lederer, David J, Lee, Joyce S, Maher, Toby M, Martinez, Fernando J, Meyer, Keith C, Mooney, Joshua J, Gall, Xavier Muñoz, Noble, Paul W, Noth, Imre, Oldham, Justin M, Alberto de Castro Pereira, Carlos, Poletti, Venerino, Selman, Moises, Spagnolo, Paolo, Renzoni, Elisabetta, Richeldi, Luca, Ryerson, Christopher J, Ryu, Jay H, Salisbury, Margaret L, Strek, Mary E, Tomassetti, Sara, Valeyre, Dominique, Vancheri, Carlo, Wijsenbeek, Marlies S, and Wuyts, Wim

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Detection, screening and diagnosis, 4.1 Discovery and preclinical testing of markers and technologies, Alveolitis, Extrinsic Allergic, Chronic Disease, Consensus, Delphi Technique, Female, Humans, Internationality, Male, Surveys and Questionnaires, hypersensitivity pneumonitis, interstitial lung disease, diagnosis, Delphi, HP Delphi Collaborators, Diagnosis, Hypersensitivity pneumonitis, Interstitial Lung Disease, Medical and Health Sciences, Respiratory System, Cardiovascular medicine and haematology, Clinical sciences
Abstract

RationaleCurrent diagnosis of chronic hypersensitivity pneumonitis (cHP) involves considering a combination of clinical, radiological, and pathological information in multidisciplinary team discussions. However, this approach is highly variable with poor agreement between centers.ObjectivesWe aimed to identify diagnostic criteria for cHP that reach consensus among international experts.MethodsA 3-round modified Delphi survey was conducted between April and August 2017. Forty-five experts in interstitial lung disease from 14 countries participated in the online survey. Diagnostic items included in round 1 were generated using expert interviews and literature review. During rounds 1 and 2, experts rated the importance of each diagnostic item on a 5-point Likert scale. The a priori threshold of consensus was ≥ 75% of experts rating a diagnostic item as very important or important. In the third round, experts graded the items that met consensus as important and provided their level of diagnostic confidence for a series of clinical scenarios.Measurements and main resultsConsensus was achieved on 18 of the 40 diagnostic items. Among these, experts gave the highest level of importance to the identification of a causative antigen, time relation between exposure and disease, mosaic attenuation on chest imaging, and poorly formed non-necrotizing granulomas on pathology. In clinical scenarios, the diagnostic confidence of experts in cHP was heightened by the presence of these diagnostic items.ConclusionThis consensus-based approach for the diagnosis of cHP represents a first step towards the development of international guidelines for the diagnosis of cHP.

Published
2018

36. Mild elevation of pulmonary vascular resistance predicts mortality regardless of mean pulmonary artery pressure in mild interstitial lung disease

Author

Sato, Tomonori, primary, Furukawa, Taiki, additional, Teramachi, Ryo, additional, Fukihara, Jun, additional, Yamano, Yasuhiko, additional, Yokoyama, Toshiki, additional, Matsuda, Toshiaki, additional, Kataoka, Kensuke, additional, Kimura, Tomoki, additional, Sakamoto, Koji, additional, Ishii, Makoto, additional, and Kondoh, Yasuhiro, additional

Published
2024
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38. 2020 guide for the diagnosis and treatment of interstitial lung disease associated with connective tissue disease

Author

Kondoh, Yasuhiro, Makino, Shigeki, Ogura, Takashi, Suda, Takafumi, Tomioka, Hiromi, Amano, Hirofumi, Anraku, Masaki, Enomoto, Noriyuki, Fujii, Takao, Fujisawa, Tomoyuki, Gono, Takahisa, Harigai, Masayoshi, Ichiyasu, Hidenori, Inoue, Yoshikazu, Johkoh, Takeshi, Kameda, Hideto, Kataoka, Kensuke, Katsumata, Yasuhiro, Kawaguchi, Yasushi, Kawakami, Atsushi, Kitamura, Hideya, Kitamura, Noboru, Koga, Tomohiro, Kurasawa, Kazuhiro, Nakamura, Yutaro, Nakashima, Ran, Nishioka, Yasuhiko, Nishiyama, Osamu, Okamoto, Masaki, Sakai, Fumikazu, Sakamoto, Susumu, Sato, Shinji, Shimizu, Toshimasa, Takayanagi, Noboru, Takei, Reoto, Takemura, Tamiko, Takeuchi, Tohru, Toyoda, Yuko, Yamada, Hidehiro, Yamakawa, Hideaki, Yamano, Yasuhiko, Yamasaki, Yoshioki, and Kuwana, Masataka

Published
2021
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41. Prognostic role of interferon‐lambda 3 in anti‐MDA5–positive dermatomyositis‐associated ILD

Author

Fukada, Atsuki, primary, Fujisawa, Tomoyuki, additional, Hozumi, Hironao, additional, Koda, Keigo, additional, Akamatsu, Taisuke, additional, Oyama, Yoshiyuki, additional, Satake, Yasuomi, additional, Niwa, Mitsuru, additional, Kaida, Yusuke, additional, Matsuda, Hiroyuki, additional, Yokomura, Koshi, additional, Koshimizu, Naoki, additional, Toyoshima, Mikio, additional, Imokawa, Shiro, additional, Hashimoto, Dai, additional, Yoshida, Akira, additional, Gono, Takahisa, additional, Kuwana, Masataka, additional, Yamano, Yasuhiko, additional, Kondoh, Yasuhiro, additional, Yamashita, Keita, additional, Maekawa, Masato, additional, Mori, Kazutaka, additional, Inoue, Yusuke, additional, Yasui, Hideki, additional, Suzuki, Yuzo, additional, Karayama, Masato, additional, Furuhashi, Kazuki, additional, Enomoto, Noriyuki, additional, Inui, Naoki, additional, and Suda, Takafumi, additional

Published
2023
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48. Prognostic Role of Interferon‐λ3 in Anti–Melanoma Differentiation–Associated Gene 5–Positive Dermatomyositis‐Associated Interstitial Lung Disease.

Author

Fukada, Atsuki, Fujisawa, Tomoyuki, Hozumi, Hironao, Koda, Keigo, Akamatsu, Taisuke, Oyama, Yoshiyuki, Satake, Yasuomi, Niwa, Mitsuru, Kaida, Yusuke, Matsuda, Hiroyuki, Yokomura, Koshi, Koshimizu, Naoki, Toyoshima, Mikio, Imokawa, Shiro, Hashimoto, Dai, Yoshida, Akira, Gono, Takahisa, Kuwana, Masataka, Yamano, Yasuhiko, and Kondoh, Yasuhiro

Subjects
MELANOMA prognosis, MORTALITY risk factors, DERMATOMYOSITIS, RISK assessment, EPITHELIAL cells, MELANOMA, MACROPHAGES, RESEARCH funding, AUTOANTIBODIES, INTERSTITIAL lung diseases, CANCER patients, MULTIVARIATE analysis, EVALUATION of medical care, TUMOR markers, INTERFERONS, GENE expression, LONGITUDINAL method, ONCOGENES, POLYMYOSITIS, CELL differentiation
Abstract

Objective: Interferon‐λ3 (IFNλ3) is a cytokine with antiviral functions on barrier surfaces, and it is associated with disease activity in autoimmune diseases. This study assessed the clinical significance of serum IFNλ3 levels in polymyositis/dermatomyositis (PM/DM)–associated interstitial lung disease (ILD). Methods: We measured serum IFNλ3 levels in 221 patients with PM/DM‐ILD (155 in the derivation cohort, 66 in the validation cohort) and 38 controls. We evaluated factors associated with mortality risk among 79 patients with anti‐melanoma differentiation–associated gene 5 (MDA5) antibody–positive DM‐ILD. Results: Serum IFNλ3 levels at diagnosis were significantly higher in patients with PM/DM‐ILD than in healthy controls. Remarkably, serum IFNλ3 levels were specifically increased in patients with anti‐MDA5 antibody–positive DM‐ILD in both the derivation and validation cohorts. In anti‐MDA5 antibody–positive DM‐ILD, patients with high IFNλ3 levels (>120 pg/mL) had significantly lower survival rates than those with low IFNλ3 levels (≤120 pg/mL). A multivariate analysis revealed that high IFNλ3 levels, as well as old age and low Pao2, were significantly associated with poor prognoses in patients with anti‐MDA5 antibody–positive DM‐ILD. In a classification analysis of patients with anti‐MDA5 antibody–positive DM‐ILD based on age, IFNλ3 level, and Pao2, patients with old age (>53 years), high IFNλ3 levels (>120 pg/mL), and low Pao2 (<75 mm Hg) had the worst survival. In lung pathologic analyses, IFNλ3‐positive staining was observed in macrophages, airway epithelial cells, the pleural region, and intrapulmonary veins in patients with anti‐MDA5 antibody–positive DM‐ILD. Conclusion: Serum IFNλ3 is a promising biomarker for identifying patients at high risk of poor outcomes in anti‐MDA5 antibody–positive DM‐ILD. [ABSTRACT FROM AUTHOR]

Published
2024
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49. Corticosteroids for hospitalized patients with mild to critically-ill COVID-19: a multicenter, retrospective, propensity score-matched study

Author

Ikeda, Satoshi, Misumi, Toshihiro, Izumi, Shinyu, Sakamoto, Keita, Nishimura, Naoki, Ro, Shosei, Fukunaga, Koichi, Okamori, Satoshi, Tachikawa, Natsuo, Miyata, Nobuyuki, Shinkai, Masaharu, Shinoda, Masahiro, Miyazaki, Yasunari, Iijima, Yuki, Izumo, Takehiro, Inomata, Minoru, Okamoto, Masaki, Yamaguchi, Tomoyoshi, Iwabuchi, Keisuke, Masuda, Makoto, Takoi, Hiroyuki, Oyamada, Yoshitaka, Fujitani, Shigeki, Mineshita, Masamichi, Ishii, Haruyuki, Nakagawa, Atsushi, Yamaguchi, Nobuhiro, Hibino, Makoto, Tsushima, Kenji, Nagai, Tatsuya, Ishikawa, Satoru, Ishikawa, Nobuhisa, Kondoh, Yasuhiro, Yamazaki, Yoshitaka, Gocho, Kyoko, Nishizawa, Tomotaka, Tsuzuku, Akifumi, Yagi, Kazuma, Shindo, Yuichiro, Takeda, Yuriko, Yamanaka, Takeharu, and Ogura, Takashi

Published
2021
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