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6. Liraglutide Improves Nonalcoholic Fatty Liver Disease in Diabetic Mice by Activating Autophagy Through AMPK/mTOR Signaling Pathway

Author

Liao Z, Huang L, Chen J, Chen T, Kong D, Wei Q, Chen Q, Deng B, Li Y, Zhong S, and Huang Z

Subjects
type 2 diabetes, nonalcoholic fatty liver disease, liraglutide, ampk/mtor, autophagy., Specialties of internal medicine, RC581-951
Abstract

Zhanlin Liao,1,* Liangzhi Huang,1,* Jun Chen,2 Ting Chen,1 Dezhi Kong,1 Qifeng Wei,1 Qiao Chen,1 Bin Deng,1 Yanyan Li,1 Shuai Zhong,1 Zugui Huang1 1Department of Endocrine, Affiliated Nanping First Hospital of Fujian Medical University, Nanping, Fujian, 353006, People’s Republic of China; 2Department of Ophthalmology, Affiliated Nanping First Hospital of Fujian Medical University, Nanping, Fujian, 353006, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zugui Huang, Department of Endocrine, Affiliated Nanping First Hospital of Fujian Medical University, No. 317 Zhongshan Road, Nanping, Fujian, 353006, People’s Republic of China, Email 15159969783@163.comBackground: Type 2 diabetes (T2DM) combined nonalcoholic fatty liver disease (NAFLD) are characterized by metabolic disruptions. Liraglutide has been proved to be effective in T2DM. If LRG could regulate NAFLD combined T2DM has not been reported.Methods: Intraperitoneal injection of 1% streptozotocin (STZ) plus high-sugar and high-fat diet was used to induce NAFLD combined T2DM animal model. Palmitic acid (200 μmol/L) and glucose (25 mmol/L) incubation were used to induce cell model. The cell apoptosis, mRNA and protein expression were measured through flow cytometry, PCR, and Western blotting, respectively.Results: Liraglutide significantly improved the liver injury of NAFLD combined T2DM rats, but Com-C reversed the effect of liraglutide. The decreased AMPK/mTOR signaling pathway in the NAFLD combined T2DM animals was greatly activated by liraglutide. Com-C reversed the protection effects of liraglutide on palmitic acid+glucose induced cell damage.Conclusion: Liraglutide could greatly alleviate the damage caused by NAFLD+T2DM and palmitic acid+glucose. The protection effects of liraglutide were greatly inhibited by suppressing AMPK/mTOR signaling pathway. This research might provide a novel therapeutic strategy for the prevention and treatment of NAFLD combined T2DM disease.Keywords: type 2 diabetes, nonalcoholic fatty liver disease, liraglutide, AMPK/mTOR, autophagy

Published
2024

7. Observation of the toroidal rotation in a new designed compact torus system for EAST

Author

Zhao, Z. H., Lan, T., Kong, D. F., Ye, Y., Zhang, S. B., Zhuang, G., Zhang, X. H., Hu, G. H., Chen, C., Wu, J., Zhang, S., Qi, M. B., Li, C. H., Yang, X. M., Nie, L. Y., Wen, F., Zi, P. F., Li, L., Meng, F. W., Li, B., Dong, Q. L., and Huang, Y. Q.

Subjects
Physics - Plasma Physics
Abstract

Compact torus injection is considered as a high promising approach to realize central fueling in the future tokamak device. Recently, a compact torus injection system has been developed for the Experimental Advanced Superconducting Tokamak, and the preliminary results have been carried out. In the typical discharges of the early stage, the velocity, electron density and particles number of the CT can reach 56.0 km/s, 8.73*10^20 m^(-3) and 2.4*10^18 (for helium), respectively. A continuous increase in CT density during acceleration was observed in the experiment, which may be due to the plasma ionized in the formation region may carry part of the neutral gas into the acceleration region, and these neutral gases will be ionized again. In addition, a significant plasma rotation is observed during the formation process which is introduced by the E*B drift. In this paper, we present the detailed system setup and the preliminary platform test results, hoping to provide some basis for the exploration of the CT technique medium-sized superconducting tokamak device in the future

Published
2022

8. A novel measurement of initial-state gluon radiation in hadron collisions using Drell-Yan events

Author

CDF Collaboration, Aaltonen, T., Amerio, S., Amidei, D., Anastassov, A., Annovi, A., Antos, J., Apollinari, G., Appel, J. A., Arisawa, T., Artikov, A., Asaadi, J., Ashmanskas, W., Auerbach, B., Aurisano, A., Azfar, F., Badgett, W., Bae, T., Barbaro-Galtieri, A., Barnes, V. E., Barnett, B. A., Barria, P., Bartos, P., Bauce, M., Bedeschi, F., Behari, S., Bellettini, G., Bellinger, J., Benjamin, D., Beretvas, A., Bhatti, A., Bland, K. R., Blumenfeld, B., Bocci, A., Bodek, A., Bortoletto, D., Boudreau, J., Boveia, A., Brigliadori, L., Bromberg, C., Brucken, E., Budagov, J., Budd, H. S., Burkett, K., Busetto, G., Bussey, P., Butti, P., Buzatu, A., Calamba, A., Camarda, S., Campanelli, M., Canelli, F., Carls, B., Carlsmith, D., Carosi, R., Carrillo, S., Casal, B., Casarsa, M., Castro, A., Catastini, P., Cauz, D., Cavaliere, V., Cerri, A., Cerrito, L., Chen, Y. C., Chertok, M., Chiarelli, G., Chlachidze, G., Cho, K., Chokheli, D., Clark, A., Clarke, C., Convery, M. E., Conway, J., Corbo, M., Cordelli, M., Cox, C. A., Cox, D. J., Cremonesi, M., Cruz, D., Cuevas, J., Culbertson, R., d'Ascenzo, N., Datta, M., de Barbaro, P., Demortier, L., Deninno, M., D'Errico, M., Devoto, F., Di Canto, A., Di Ruzza, B., Dittmann, J. R., Donati, S., D'Onofrio, M., Dorigo, M., Driutti, A., Ebina, K., Edgar, R., Elagin, A., Erbacher, R., Errede, S., Esham, B., Farrington, S., Ramos, J. P. Fernández, Field, R., Flanagan, G., Forrest, R., Franklin, M., Freeman, J. C., Frisch, H., Funakoshi, Y., Galloni, C., Garfinkel, A. F., Garosi, P., Gerberich, H., Gerchtein, E., Giagu, S., Giakoumopoulou, V., Gibson, K., Ginsburg, C. M., Giokaris, N., Giromini, P., Glagolev, V., Glenzinski, D., Gold, M., Goldin, D., Golossanov, A., Gomez, G., Gomez-Ceballos, G., Goncharov, M., López, O. González, Gorelov, I., Goshaw, A. T., Goulianos, K., Gramellini, E., Grosso-Pilcher, C., da Costa, J. Guimaraes, Hahn, S. R., Han, J. Y., Happacher, F., Hara, K., Hare, M., Harr, R. F., Harrington-Taber, T., Hatakeyama, K., Hays, C., Heinrich, J., Herndon, M., Hocker, A., Hong, Z., Hopkins, W., Hou, S., Hughes, R. E., Husemann, U., Hussein, M., Huston, J., Introzzi, G., Iori, M., Ivanov, A., James, E., Jang, D., Jayatilaka, B., Jeon, E. J., Jindariani, S., Jones, M., Joo, K. K., Jun, S. Y., Junk, T. R., Kambeitz, M., Kamon, T., Karchin, P. E., Kasmi, A., Kato, Y., Ketchum, W., Keung, J., Kilminster, B., Kim, D. H., Kim, H. S., Kim, J. E., Kim, M. J., Kim, S. H., Kim, S. B., Kim, Y. J., Kim, Y. K., Kimura, N., Kirby, M., Kondo, K., Kong, D. J., Konigsberg, J., Kotwal, A. V., Kreps, M., Kroll, J., Kruse, M., Kuhr, T., Kurata, M., Laasanen, A. T., Lammel, S., Lancaster, M., Lannon, K., Latino, G., Lee, H. S., Lee, J. S., Leo, S., Leone, S., Lewis, J. D., Limosani, A., Lipeles, E., Lister, A., Liu, Q., Liu, T., Lockwitz, S., Loginov, A., Lucchesi, D., Lucà, A., Lueck, J., Lujan, P., Lukens, P., Lungu, G., Lys, J., Lysak, R., Madrak, R., Maestro, P., Malik, S., Manca, G., Manousakis-Katsikakis, A., Marchese, L., Margaroli, F., Marino, P., Matera, K., Mattson, M. E., Mazzacane, A., Mazzanti, P., McNulty, R., Mehta, A., Mehtala, P., Mesropian, C., Miao, T., Michielin, E., Mietlicki, D., Mitra, A., Miyake, H., Moed, S., Moggi, N., Moon, C. S., Moore, R., Morello, M. J., Mukherjee, A., Muller, Th., Murat, P., Mussini, M., Nachtman, J., Nagai, Y., Naganoma, J., Nakano, I., Napier, A., Nett, J., Nigmanov, T., Nodulman, L., Noh, S. Y., Norniella, O., Oakes, L., Oh, S. H., Oh, Y. D., Okusawa, T., Orava, R., Ortolan, L., Pagliarone, C., Palencia, E., Palni, P., Papadimitriou, V., Parker, W., Pauletta, G., Paulini, M., Paus, C., Phillips, T. J., Piacentino, G., Pianori, E., Pilot, J., Pitts, K., Plager, C., Pondrom, L., Poprocki, S., Potamianos, K., Pranko, A., Prokoshin, F., Ptohos, F., Punzi, G., Fernández, I. Redondo, Renton, P., Rescigno, M., Rimondi, F., Ristori, L., Robson, A., Rodriguez, T., Rolli, S., Ronzani, M., Roser, R., Rosner, J. L., Ruffini, F., Ruiz, A., Russ, J., Rusu, V., Sakumoto, W. K., Sakurai, Y., Santi, L., Sato, K., Saveliev, V., Savoy-Navarro, A., Schlabach, P., Schmidt, E. E., Schwarz, T., Scodellaro, L., Scuri, F., Seidel, S., Seiya, Y., Semenov, A., Seo, H., Sforza, F., Shalhout, S. Z., Shears, T., Shepard, P. F., Shimojima, M., Shochet, M., Shreyber-Tecker, I., Simonenko, A., Sliwa, K., Smith, J. R., Snider, F. D., Song, H., Sorin, V., Denis, R. St., Stancari, M., Stentz, D., Strologas, J., Sudo, Y., Sukhanov, A., Suslov, I., Takemasa, K., Takeuchi, Y., Tang, J., Tecchio, M., Teng, P. K., Thom, J., Thomson, E., Thukral, V., Toback, D., Tokar, S., Tollefson, K., Tomura, T., Tonelli, D., Torre, S., Torretta, D., Totaro, P., Trovato, M., Ukegawa, F., Uozumi, S., Vázquez, F., Velev, G., Vellidis, C., Vernieri, C., Vidal, M., Vilar, R., Vizán, J., Vogel, M., Volpi, G., Wagner, P., Wallny, R., Wang, S. M., Waters, D., Wester III, W. C., Whiteson, D., Wicklund, A. B., Wilbur, S., Williams, H. H., Wilson, J. S., Wilson, P., Winer, B. L., Wittich, P., Wolbers, S., Wolfmeister, H., Wright, T., Wu, X., Wu, Z., Yamamoto, K., Yamato, D., Yang, T., Yang, U. K., Yang, Y. C., Yao, W. -M., Yeh, G. P., Yi, K., Yoh, J., Yorita, K., Yoshida, T., Yu, G. B., Yu, I., Zanetti, A. M., Zeng, Y., Zhou, C., and Zucchelli, S.

Subjects
High Energy Physics - Experiment
Abstract

A study of initial-state gluon radiation (ISR) in hadron collisions is presented using Drell-Yan (DY) events produced in proton-antiproton collisions by the Tevatron collider at a center-of-mass energy of 1.96 TeV. This paper adopts a novel approach which uses the mean value of the Z/$\gamma^*$ transverse momentum $$ in DY events as a powerful observable to characterize the effect of ISR. In a data sample corresponding to an integrated luminosity of 9.4 fb$^{-1}$ collected with the CDF Run II detector, $$ is measured as a function of the Z/$\gamma^*$ invariant mass. It is found that these two observables have a dependence, $ = -8 + 2.2 \ln m_{DY}^2$ [GeV/c], where $m_{DY}$ is the value of the Z/$\gamma^*$ mass measured in units of GeV/$c^2$. This linear dependence is observed for the first time in this analysis. It may be exploited to model the effect of ISR and constrain its impact in other processes., Comment: 14 pages, 14 figures

Published
2021

11. Measurement of the charge asymmetry of electrons from the decays of $W$ bosons produced in $p\bar{p}$ collisions at $\sqrt{s}=1.96$ TeV

Author

CDF Collaboration, Aaltonen, T., Amerio, S., Amidei, D., Anastassov, A., Annovi, A., Antos, J., Apollinari, G., Appel, J. A., Arisawa, T., Artikov, A., Asaadi, J., Ashmanskas, W., Auerbach, B., Aurisano, A., Azfar, F., Badgett, W., Bae, T., Barbaro-Galtieri, A., Barnes, V. E., Barnett, B. A., Barria, P., Bartos, P., Bauce, M., Bedeschi, F., Behari, S., Bellettini, G., Bellinger, J., Benjamin, D., Beretvas, A., Bhatti, A., Bland, K. R., Blumenfeld, B., Bocci, A., Bodek, A., Bortoletto, D., Boudreau, J., Boveia, A., Brigliadori, L., Bromberg, C., Brucken, E., Budagov, J., Budd, H. S., Burkett, K., Busetto, G., Bussey, P., Butti, P., Buzatu, A., Calamba, A., Camarda, S., Campanelli, M., Canelli, F., Carls, B., Carlsmith, D., Carosi, R., Carrillo, S., Casal, B., Casarsa, M., Castro, A., Catastini, P., Cauz, D., Cavaliere, V., Cerri, A., Cerrito, L., Chen, Y. C., Chertok, M., Chiarelli, G., Chlachidze, G., Cho, K., Chokheli, D., Clark, A., Clarke, C., Convery, M. E., Conway, J., Corbo, M., Cordelli, M., Cox, C. A., Cox, D. J., Cremonesi, M., Cruz, D., Cuevas, J., Culbertson, R., d'Ascenzo, N., Datta, M., de Barbaro, P., Demortier, L., Deninno, M., D'Errico, M., Devoto, F., Di Canto, A., Di Ruzza, B., Dittmann, J. R., Donati, S., D'Onofrio, M., Dorigo, M., Driutti, A., Ebina, K., Edgar, R., Elagin, A., Erbacher, R., Errede, S., Esham, B., Farrington, S., Ramos, J. P. Fernández, Field, R., Flanagan, G., Forrest, R., Franklin, M., Freeman, J. C., Frisch, H., Funakoshi, Y., Galloni, C., Garfinkel, A. F., Garosi, P., Gerberich, H., Gerchtein, E., Giagu, S., Giakoumopoulou, V., Gibson, K., Ginsburg, C. M., Giokaris, N., Giromini, P., Glagolev, V., Glenzinski, D., Gold, M., Goldin, D., Golossanov, A., Gomez, G., Gomez-Ceballos, G., Goncharov, M., López, O. González, Gorelov, I., Goshaw, A. T., Goulianos, K., Gramellini, E., Grosso-Pilcher, C., da Costa, J. Guimaraes, Hahn, S. R., Han, J. Y., Happacher, F., Hara, K., Hare, M., Harr, R. F., Harrington-Taber, T., Hatakeyama, K., Hays, C., Heinrich, J., Herndon, M., Hocker, A., Hong, Z., Hopkins, W., Hou, S., Hughes, R. E., Husemann, U., Hussein, M., Huston, J., Introzzi, G., Iori, M., Isgrò, A., Ivanov, A., James, E., Jang, D., Jayatilaka, B., Jeon, E. J., Jindariani, S., Jones, M., Joo, K. K., Jun, S. Y., Junk, T. R., Kambeitz, M., Kamon, T., Karchin, P. E., Kasmi, A., Kato, Y., Ketchum, W., Keung, J., Kilminster, B., Kim, D. H., Kim, H. S., Kim, J. E., Kim, M. J., Kim, S. H., Kim, S. B., Kim, Y. J., Kim, Y. K., Kimura, N., Kirby, M., Kondo, K., Kong, D. J., Konigsberg, J., Kotwal, A. V., Kreps, M., Kroll, J., Kruse, M., Kuhr, T., Kurata, M., Laasanen, A. T., Lammel, S., Lancaster, M., Lannon, K., Latino, G., Lee, H. S., Lee, J. S., Leo, S., Leone, S., Lewis, J. D., Limosani, A., Lipeles, E., Lister, A., Liu, Q., Liu, T., Lockwitz, S., Loginov, A., Lucchesi, D., Lucà, A., Lueck, J., Lujan, P., Lukens, P., Lungu, G., Lys, J., Lysak, R., Madrak, R., Maestro, P., Malik, S., Manca, G., Manousakis-Katsikakis, A., Marchese, L., Margaroli, F., Marino, P., Matera, K., Mattson, M. E., Mazzacane, A., Mazzanti, P., McNulty, R., Mehta, A., Mehtala, P., Mesropian, C., Miao, T., Michielin, E., Mietlicki, D., Mitra, A., Miyake, H., Moed, S., Moggi, N., Moon, C. S., Moore, R., Morello, M. J., Mukherjee, A., Muller, Th., Murat, P., Mussini, M., Nachtman, J., Nagai, Y., Naganoma, J., Nakano, I., Napier, A., Nett, J., Nigmanov, T., Nodulman, L., Noh, S. Y., Norniella, O., Oakes, L., Oh, S. H., Oh, Y. D., Okusawa, T., Orava, R., Ortolan, L., Pagliarone, C., Palencia, E., Palni, P., Papadimitriou, V., Parker, W., Pauletta, G., Paulini, M., Paus, C., Phillips, T. J., Piacentino, G., Pianori, E., Pilot, J., Pitts, K., Plager, C., Pondrom, L., Poprocki, S., Potamianos, K., Pranko, A., Prokoshin, F., Ptohos, F., Punzi, G., Fernández, I. Redondo, Renton, P., Rescigno, M., Rimondi, F., Ristori, L., Robson, A., Rodriguez, T., Rolli, S., Ronzani, M., Roser, R., Rosner, J. L., Ruffini, F., Ruiz, A., Russ, J., Rusu, V., Sakumoto, W. K., Sakurai, Y., Santi, L., Sato, K., Saveliev, V., Savoy-Navarro, A., Schlabach, P., Schmidt, E. E., Schwarz, T., Scodellaro, L., Scuri, F., Seidel, S., Seiya, Y., Semenov, A., Sforza, F., Shalhout, S. Z., Shears, T., Shepard, P. F., Shimojima, M., Shochet, M., Shreyber-Tecker, I., Simonenko, A., Sliwa, K., Smith, J. R., Snider, F. D., Song, H., Sorin, V., Denis, R. St., Stancari, M., Stentz, D., Strologas, J., Sudo, Y., Sukhanov, A., Suslov, I., Takemasa, K., Takeuchi, Y., Tang, J., Tecchio, M., Teng, P. K., Thom, J., Thomson, E., Thukral, V., Toback, D., Tokar, S., Tollefson, K., Tomura, T., Tonelli, D., Torre, S., Torretta, D., Totaro, P., Trovato, M., Ukegawa, F., Uozumi, S., Vecchio, V., Velev, G., Vellidis, C., Vernieri, C., Vidal, M., Vilar, R., Vizán, J., Vogel, M., Volpi, G., Vázquez, F., Wagner, P., Wallny, R., Wang, S. M., Waters, D., Wester III, W. C., Whiteson, D., Wicklund, A. B., Wilbur, S., Williams, H. H., Wilson, J. S., Wilson, P., Winer, B. L., Wittich, P., Wolbers, S., Wolfmeister, H., Wright, T., Wu, X., Wu, Z., Yamamoto, K., Yamato, D., Yang, T., Yang, U. K., Yang, Y. C., Yao, W. -M., Yeh, G. P., Yi, K., Yoh, J., Yorita, K., Yoshida, T., Yu, G. B., Yu, I., Zanetti, A. M., Zeng, Y., Zhou, C., and Zucchelli, S.

Subjects
High Energy Physics - Experiment
Abstract

At the Fermilab Tevatron proton-antiproton ($p\bar{p}$) collider, high-mass electron-neutrino ($e\nu$) pairs are produced predominantly in the process $p \bar{p} \rightarrow W(\rightarrow e\nu) + X$. The asymmetry of the electron and positron yield as a function of their pseudorapidity constrain the slope of the ratio of the $u$- to $d$-quark parton distributions versus the fraction of the proton momentum carried by the quarks. This paper reports on the measurement of the electron-charge asymmetry using the full data set recorded by the Collider Detector at Fermilab in 2001--2011 and corresponding to 9.1~fb$^{-1}$ of integrated luminosity. The measurement significantly improves the precision of the Tevatron constraints on the parton-distribution functions of the proton. Numerical tables of the measurement are provided., Comment: 27 pages, 25 figures. To be published in PRD

Published
2021

12. Serum Uric Acid to Creatinine Ratio and Risk of Metabolic Syndrome in Patients with Overweight/Obesity

Author

She D, Xu W, Liu J, Zhang Z, Fang P, Li R, Kong D, Xuan M, Liu Q, Pan MY, Wang Y, and Xue Y

Subjects
metabolic syndrome, serum uric acid to creatinine ratio, overweight/obesity, Specialties of internal medicine, RC581-951
Abstract

Dunmin She,1,2,&ast; Wei Xu,3,&ast; Jing Liu,4,&ast; Zikai Zhang,5 Ping Fang,3 Ran Li,3 Dehong Kong,3 Miao Xuan,3 Qi Liu,3 Mo Yuan Pan,6 Yan Wang,1,2 Ying Xue3 1Clinical Medical College, Yangzhou University, Yangzhou, Jiangsu, People’s Republic of China; 2Department of Endocrinology, Northern Jiangsu People’s Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu, People’s Republic of China; 3Department of Endocrinology and Metabolism, Tongji Hospital, School of Medicine, Tongji University, Shanghai, People’s Republic of China; 4Dalian Medical University, Dalian, Liaoning, People’s Republic of China; 5Department of Oncology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, People’s Republic of China; 6The Second Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Ying Xue, Department of Endocrinology and Metabolism, Tongji Hospital, School of Medicine, Tongji University, No. 389, Xincun Road, Shanghai, People’s Republic of China, Tel +86-21-66111061, Email doxy0622@163.com Yan Wang, Clinical Medical College, Yangzhou University, No. 98, Nantong West Road, Yangzhou, Jiangsu Province, People’s Republic of China, Email yzyan1972@126.comPurpose: Metabolic syndrome (MetS) is a rising global concern with an increasing prevalence. This study aimed to evaluate the relationship between serum uric acid to creatinine ratio (SUA/Cr) and MetS in adults with overweight/obesity in China.Patients and Methods: We conducted a cross-sectional study comprising 4699 participants with overweight/obesity who underwent physical examinations. Their serum levels of various components, including total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), fasting plasma glucose (FPG), creatinine (Cr), and uric acid (UA) were measured. Renal function-normalized SUA was calculated using SUA/Cr. Logistic regression analysis was employed to investigate the association between SUA/Cr and MetS in adults with overweight/obesity.Results: SUA/Cr levels were lower in non-MetS participants (OR: 2.159, 95% CI: 1.82 to 2.56; p < 0.001), and tended to rise with the increasing number of MetS components. Additionally, elevated SUA/Cr levels were associated with a higher risk of hypertension, hyperglycemia, and dyslipidemia.Conclusion: SUA/Cr levels were significantly associated with MetS and its components in Chinese adults with overweight/obesity.Keywords: metabolic syndrome, serum uric acid to creatinine ratio, overweight/obesity

Published
2023

15. Identifying Metabolic Syndrome Easily and Cost Effectively Using Non-Invasive Methods with Machine Learning Models

Author

Xu W, Zhang Z, Hu K, Fang P, Li R, Kong D, Xuan M, Yue Y, She D, and Xue Y

Subjects
metabolic syndrome, machine learning methods, non-invasive method, naive bayesian, Specialties of internal medicine, RC581-951
Abstract

Wei Xu,1,&ast; Zikai Zhang,2,&ast; Kerong Hu,1,&ast; Ping Fang,1 Ran Li,1 Dehong Kong,1 Miao Xuan,1 Yang Yue,3 Dunmin She,4,5 Ying Xue1 1Department of Endocrinology and Metabolism, Tongji Hospital, School of Medicine, Tongji University, Shanghai, People’s Republic of China; 2Department of Oncology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, People’s Republic of China; 3School of Mathematics and Statistics, University of Melbourne, Melbourne, Australia; 4Clinical Medical College, Yangzhou University, Yangzhou, Jiangsu, People’s Republic of China; 5Department of Endocrinology, Northern Jiangsu People’s Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Ying Xue, Department of Endocrinology and Metabolism, Tongji Hospital, School of Medicine, Tongji University, No. 389, Xincun Road, Shanghai, People’s Republic of China, Tel +86-21-66111061, Email doxy0622@163.com Dunmin She, Clinical Medical College, Yangzhou University, No. 98, Nantong West Road, Yangzhou, Jiangsu, People’s Republic of China, Email sdm1979@126.comPurpose: The objective of this study was to employ machine learning (ML) models utilizing non-invasive factors to achieve early and low-cost identification of MetS in a large physical examination population.Patients and Methods: The study enrolled 9171 participants who underwent physical examinations at Northern Jiangsu People’s Hospital in 2009 and 2019, to determine MetS based on criteria established by the Chinese Diabetes Society. Non-invasive characteristics such as gender, age, body mass index (BMI), systolic blood pressure (SBP), and diastolic blood pressure (DBP) were collected and used as input variables to train and evaluate ML models for MetS identification. Several ML models were used for MetS identification, including logistic regression (LR), k-nearest neighbors algorithm (k-NN), naive bayesian (NB), decision tree (DT), random forest (RF), artificial neural network (ANN), and support vector machine (SVM).Results: Our ML models all showed good performance in the 10-fold cross-validation except for the SVM model. In the external validation, the NB model exhibited the best performance with an AUC of 0.976, accuracy of 0.923, sensitivity of 98.32%, and specificity of 91.32%.Conclusion: This study proposed a new non-invasive method for early and low-cost identification of MetS by using ML models. This approach has the potential to serve as a highly sensitive, convenient, and cost-effective tool for large-scale MetS screening.Keywords: metabolic syndrome, machine learning methods, non-invasive method, naive Bayesian

Published
2023

16. Triggering mechanism and material transfer of a failed solar filament eruption

Author

Yan, X. L., Xue, Z. K., Cheng, X., Zhang, J., Wang, J. C., Kong, D. F., Yang, L. H., Chen, G. R., and Feng, X. S.

Subjects
Astrophysics - Solar and Stellar Astrophysics
Abstract

Soar filament eruptions are often associated with solar flares and coronal mass ejections (CMEs), which are the major impacts on space weather. However, the fine structures and the trigger mechanisms of solar filaments are still unclear. To address these issues, we studied a failed solar active-region filament eruption associated with a C-class flare by using high-resolution H$\alpha$ images from the New Vacuum Solar Telescope (NVST), supplemented by EUV observations of the Solar Dynamical Observatory (SDO). Before the filament eruption, a small bi-pole magnetic field emerged below the filament. And then magnetic reconnection between the filament and the emerging bi-pole magnetic field triggered the filament eruption. During the filament eruption, the untwisting motion of the filament can be clearly traced by the eruptive threads. Moreover, the foot-points of the eruptive threads are determined by tracing the descending filament materials. Note that the filament twisted structure and the right part of the eruptive filament threads cannot be seen before the filament eruption. These eruptive threads at the right part of the filament are found to be rooting in the weak negative polarities near the main negative sunspot. Moreover, a new filament formed in the filament channel due to material injection from the eruptive filament. The above observations and the potential field extrapolations are inclined to support that the filament materials were transferred into the overlying magnetic loops and the nearby filament channel by magnetic reconnection. These observations shed light on better understanding on the complexity of filament eruptions., Comment: 20 pages, 11 figures, accepted for publication in ApJ

Published
2019
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17. A Case of Anaplastic Large Cell Lymphoma Misdiagnosed with Keloid

Author

Kong D and Deng D

Subjects
primary cutaneous alk-negative anaplastic large cell lymphoma, keloid, misdiagnosis, Dermatology, RL1-803
Abstract

Di Kong, Danqi Deng Department of Dermatology, Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650101, People’s Republic of ChinaCorrespondence: Danqi Deng, Fax +86-871-65351214, Email danqid128@sina.comAbstract: We report a case of a patient initially diagnosed with keloid and eventually diagnosed by skin histopathology and immunohistochemistry with primary cutaneous ALK-negative anaplastic large cell lymphoma.Keywords: primary cutaneous ALK-negative anaplastic large cell lymphoma, keloid, misdiagnosis

Published
2023

18. Radiomics Nomogram Model Based on TOF-MRA Images: A New Effective Method for Predicting Microaneurysms

Author

Kong D, Li J, Lv Y, Wang M, Li S, Qian B, and Yu Y

Subjects
machine learning, radiomics, micro-aneurysms, nomogram, Medicine (General), R5-920
Abstract

Delian Kong,1,&ast; Junrong Li,1,&ast; Yingying Lv,1,&ast; Man Wang,2,&ast; Shenghua Li,1 Baoxin Qian,3 Yusheng Yu2 1Department of Neurology, The Affiliated Jiangning Hospital with Nanjing Medical University, Nanjing, Jiangsu, 211100, People’s Republic of China; 2Department of Radiology, The Affiliated Jiangning Hospital with Nanjing Medical University, Nanjing, Jiangsu, 211100, People’s Republic of China; 3Huiying Medical Technology (Beijing); Huiying Medical Technology Co., Ltd, Beijing City, 100192, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Delian Kong; Yusheng Yu, Email xykdl@163.com; yayiba2063@163.comObjective: To develop a radiomics nomogram model based on time-of-flight magnetic resonance angiography (TOF-MRA) images for preoperative prediction of true microaneurysms.Methods: 118 patients with Intracranial Aneurysm Sac (40 positive and 78 negative) were enrolled and allocated to training and validation groups (8:2 ratio). Findings of clinical characteristics and MRA features were analyzed. A radiomics signature was built on the basis of reproducible features by using the least absolute shrinkage and selection operator (LASSO) regression algorithm in the training group. The radiomics nomogram model was constructed by combining clinical risk factors and radiomics signature. In order to compare the classification performance of clinical models, radiomics model and radiomics nomogram model, AUC was used to evaluate them. The performance of the radiomics nomogram model was evaluated by calibration curve and decision curve analysis.Results: Eleven features were selected to develop radiomics model with AUC of 0.875 (95% CI 0.78– 0.97), sensitivity of 0.84, and specificity of 0.68. The radiomics model achieved a better diagnostic performance than the clinic model (AUC = 0.75, 95% CI: 0.53– 0.97) and even radiologists. The radiomics nomogram model, which combines radiomics signature and clinical risk factors, is effective too (AUC = 0.913, 95% CI: 0.87– 0.96). Furthermore, the decision curve analysis demonstrated significantly better net benefit in the radiomics nomogram model.Conclusion: Radiomics features derived from TOF-MRA can reliably be used to build a radiomics nomogram model for effectively differentiating between pseudo microaneurysms and true microaneurysms, and it can provide an objective basis for the selection of clinical treatment plans.Keywords: machine learning, radiomics, microaneurysms, nomogram

Published
2023

19. I-mode investigation on the Experimental Advanced Superconducting Tokamak

Author

Feng, X., Liu, A. D., Zhou, C., Liu, Z. X., Wang, M. Y., Zhuang, G., Zou, X. L., Wang, T. B., Zhang, Y. Z., Xie, J. L., Liu, H. Q., Zhang, T., Liu, Y., Duan, Y. M., Hu, L. Q., Hu, G. H., Kong, D. F., Wang, S. X., Zhao, H. L., Li, Y. Y., Shao, L. M., Xia, T. Y., Ding, W. X., Lan, T., Li, H., Mao, W. Z., Liu, W. D., Gao, X., Li, J. G., Zhang, S. B., Zhang, X. H., Liu, Z. Y., Qu, C. M., Zhang, S., Zhang, J., Ji, J. X., Fan, H. R., and Zhong, X. M.

Subjects
Physics - Plasma Physics
Abstract

By analyzing large quantities of discharges in the unfavorable ion $ \vec B\times \nabla B $ drift direction, the I-mode operation has been confirmed in EAST tokamak. During the L-mode to I-mode transition, the energy confinement has a prominent improvement by the formation of a high-temperature edge pedestal, while the particle confinement remains almost identical to that in the L-mode. Similar with the I-mode observation on other devices, the $ E_r $ profiles obtained by the eight-channel Doppler backscattering system (DBS8)\cite{J.Q.Hu} show a deeper edge $ E_r $ well in the I-mode than that in the L-mode. And a weak coherent mode (WCM) with the frequency range of 40-150 kHz is observed at the edge plasma with the radial extend of about 2-3 cm. WCM could be observed in both density fluctuation and radial electric field fluctuation, and the bicoherence analyses showed significant couplings between WCM and high frequency turbulence, implying that the $ E_r $ fluctuation and the caused flow shear from WCM should play an important role during I-mode. In addition, a low-frequency oscillation with a frequency range of 5-10 kHz is always accompanied with WCM, where GAM intensity is decreased or disappeared. Many evidences show that the a low-frequency oscillation may be a novel kind of limited cycle oscillation but further investigations are needed to explain the new properties such as the harmonics and obvious magnetical perturbations., Comment: 14 pages, 7 figures

Published
2019
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20. Search for Higgs-like particles produced in association with bottom quarks in proton-antiproton collisions

Author

CDF Collaboration, Aaltonen, T., Amerio, S., Amidei, D., Anastassov, A., Annovi, A., Antos, J., Apollinari, G., Appel, J. A., Arisawa, T., Artikov, A., Asaadi, J., Ashmanskas, W., Auerbach, B., Aurisano, A., Azfar, F., Badgett, W., Bae, T., Barbaro-Galtieri, A., Barnes, V. E., Barnett, B. A., Barria, P., Bartos, P., Bauce, M., Bedeschi, F., Behari, S., Bellettini, G., Bellinger, J., Benjamin, D., Beretvas, A., Bhatti, A., Bland, K. R., Blumenfeld, B., Bocci, A., Bodek, A., Bortoletto, D., Boudreau, J., Boveia, A., Brigliadori, L., Bromberg, C., Brucken, E., Budagov, J., Budd, H. S., Burkett, K., Busetto, G., Bussey, P., Butti, P., Buzatu, A., Calamba, A., Camarda, S., Campanelli, M., Canelli, F., Carls, B., Carlsmith, D., Carosi, R., Carrillo, S., Casal, B., Casarsa, M., Castro, A., Catastini, P., Cauz, D., Cavaliere, V., Cerri, A., Cerrito, L., Chen, Y. C., Chertok, M., Chiarelli, G., Chlachidze, G., Cho, K., Chokheli, D., Clark, A., Clarke, C., Convery, M. E., Conway, J., Corbo, M., Cordelli, M., Cox, C. A., Cox, D. J., Cremonesi, M., Cruz, D., Cuevas, J., Culbertson, R., d'Ascenzo, N., Datta, M., de Barbaro, P., Demortier, L., Deninno, M., Devoto, F., D'Errico, M., Di Canto, A., Di Ruzza, B., Dittmann, J. R., D'Onofrio, M., Donati, S., Dorigo, M., Driutti, A., Ebina, K., Edgar, R., Elagin, A., Erbacher, R., Errede, S., Esham, B., Farrington, S., Ramos, J. P. Fernández, Field, R., Flanagan, G., Forrest, R., Franklin, M., Freeman, J. C., Frisch, H., Funakoshi, Y., Galloni, C., Garfinkel, A. F., Garosi, P., Gerberich, H., Gerchtein, E., Giagu, S., Giakoumopoulou, V., Gibson, K., Ginsburg, C. M., Giokaris, N., Giromini, P., Glagolev, V., Glenzinski, D., Gold, M., Goldin, D., Golossanov, A., Gomez, G., Gomez-Ceballos, G., Goncharov, M., López, O. González, Gorelov, I., Goshaw, A. T., Goulianos, K., Gramellini, E., Grosso-Pilcher, C., da Costa, J. Guimaraes, Hahn, S. R., Han, J. Y., Happacher, F., Hara, K., Hare, M., Harr, R. F., Harrington-Taber, T., Hatakeyama, K., Hays, C., Heinrich, J., Herndon, M., Hocker, A., Hong, Z., Hopkins, W., Hou, S., Hughes, R. E., Husemann, U., Hussein, M., Huston, J., Introzzi, G., Iori, M., Ivanov, A., James, E., Jang, D., Jayatilaka, B., Jeon, E. J., Jindariani, S., Jones, M., Joo, K. K., Jun, S. Y., Junk, T. R., Kambeitz, M., Kamon, T., Karchin, P. E., Kasmi, A., Kato, Y., Ketchum, W., Keung, J., Kilminster, B., Kim, D. H., Kim, H. S., Kim, J. E., Kim, M. J., Kim, S. B., Kim, S. H., Kim, Y. K., Kim, Y. J., Kimura, N., Kirby, M., Kondo, K., Kong, D. J., Konigsberg, J., Kotwal, A. V., Kreps, M., Kroll, J., Kruse, M., Kuhr, T., Kurata, M., Laasanen, A. T., Lammel, S., Lancaster, M., Lannon, K., Latino, G., Lee, H. S., Lee, J. S., Leo, S., Leone, S., Lewis, J. D., Limosani, A., Lipeles, E., Lister, A., Liu, Q., Liu, T., Lockwitz, S., Loginov, A., Lucà, A., Lucchesi, D., Lueck, J., Lujan, P., Lukens, P., Lungu, G., Lys, J., Lysak, R., Madrak, R., Maestro, P., Malik, S., Manca, G., Manousakis-Katsikakis, A., Marchese, L., Margaroli, F., Marino, P., Matera, K., Mattson, M. E., Mazzacane, A., Mazzanti, P., McNulty, R., Mehta, A., Mehtala, P., Mesropian, C., Miao, T., Michielin, E., Mietlicki, D., Mitra, A., Miyake, H., Moed, S., Moggi, N., Moon, C. S., Moore, R., Morello, M. J., Mukherjee, A., Muller, Th., Murat, P., Mussini, M., Nachtman, J., Nagai, Y., Naganoma, J., Nakano, I., Napier, A., Nett, J., Nigmanov, T., Nodulman, L., Noh, S. Y., Norniella, O., Oakes, L., Oh, S. H., Oh, Y. D., Okusawa, T., Orava, R., Ortolan, L., Pagliarone, C., Palencia, E., Palni, P., Papadimitriou, V., Parker, W., Pauletta, G., Paulini, M., Paus, C., Phillips, T. J., Piacentino, G., Pianori, E., Pilot, J., Pitts, K., Plager, C., Pondrom, L., Poprocki, S., Potamianos, K., Prokoshin, F., Pranko, A., Ptohos, F., Punzi, G., Fernández, I. Redondo, Renton, P., Rescigno, M., Rimondi, F., Ristori, L., Robson, A., Rodriguez, T., Rolli, S., Ronzani, M., Roser, R., Rosner, J. L., Ruffini, F., Ruiz, A., Russ, J., Rusu, V., Sakumoto, W. K., Sakurai, Y., Santi, L., Sato, K., Saveliev, V., Savoy-Navarro, A., Schlabach, P., Schmidt, E. E., Schwarz, T., Scodellaro, L., Scuri, F., Seidel, S., Seiya, Y., Semenov, A., Sforza, F., Shalhout, S. Z., Shears, T., Shepard, P. F., Shimojima, M., Shochet, M., Shreyber-Tecker, I., Simonenko, A., Sliwa, K., Smith, J. R., Snider, F. D., Sorin, V., Song, H., Stancari, M., Denis, R. St., Stentz, D., Strologas, J., Sudo, Y., Sukhanov, A., Suslov, I., Takemasa, K., Takeuchi, Y., Tang, J., Tecchio, M., Teng, P. K., Thom, J., Thomson, E., Thukral, V., Toback, D., Tokar, S., Tollefson, K., Tomura, T., Tonelli, D., Torre, S., Torretta, D., Totaro, P., Trovato, M., Ukegawa, F., Uozumi, S., Vázquez, F., Velev, G., Vellidis, C., Vernieri, C., Vidal, M., Vilar, R., Vizán, J., Vogel, M., Volpi, G., Wagner, P., Wallny, R., Wang, S. M., Waters, D., Wester III, W. C., Whiteson, D., Wicklund, A. B., Wilbur, S., Williams, H. H., Wilson, J. S., Wilson, P., Winer, B. L., Wittich, P., Wolbers, S., Wolfmeister, H., Wright, T., Wu, X., Wu, Z., Yamamoto, K., Yamato, D., Yang, T., Yang, U. K., Yang, Y. C., Yao, W. -M., Yeh, G. P., Yi, K., Yoh, J., Yorita, K., Yoshida, T., Yu, G. B., Yu, I., Zanetti, A. M., Zeng, Y., Zhou, C., and Zucchelli, S.

Subjects
High Energy Physics - Experiment
Abstract

We report on a search for a spin-zero non-standard-model particle in proton-antiproton collisions collected by the Collider Detector at Fermilab at a center-of-mass-energy of 1.96 TeV. This particle, the $\phi$ boson, is expected to decay into a bottom-antibottom quark pair and to be produced in association with at least one bottom quark. The data sample consists of events with three jets identified as initiated by bottom quarks and corresponds to $5.4~\text{fb}^{-1}$ of integrated luminosity. In each event, the invariant mass of the two most energetic jets is studied by looking for deviations from the multijet background, which is modeled using data. No evidence is found for such particle. Exclusion upper limits ranging from 20 to 2 pb are set for the product of production cross sections times branching fraction for hypothetical $\phi$ boson with mass between 100 and 300 GeV/$c^2$. These are the most stringent constraints to date., Comment: submitted to PRD

Published
2019
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21. Analysis of Testbeam Data of the Highly Granular RPC-Steel CALICE Digital Hadron Calorimeter and Validation of Geant4 Monte Carlo Models

Author

CALICE Collaboration, Chefdeville, M., Repond, J., Schlereth, J., Smith, J. R., Trojand, D., Xia, L., Zhang, Q., Apostolakis, J., Grefe, C., Ivantchenko, V., Folger, G., Ribon, A., Uzhinskiy, V., Blazey, G. C., Dyshkant, A., Francis, K., Zutshi, V., Bach, O., Bocharnikov, V., Brianne, E., Gadow, K., Göttlicher, P., Hartbrich, O., Heuchel, D., Krivan, F., Krüger, K., Kvasnicka, J., Lu, S., Neubüser, C., Pinto, O., Provenza, A., Reinecke, M., Sefkow, F., Schuwalow, S., Sudo, Y., Tran, H. L., Buhmann, P., Garutti, E., Lomidze, D., Martens, S., Matysek, M., Bilki, B., Northacker, D., Onel, Y., van Doren, B., Wilson, G. W., Kawagoe, K., Miura, Y., Mori, R., Sekiya, I., Suehara, T., Yoshioka, T., Belver, D., Alamillo, E. Calvo, Fouz, M. C., Cabrera, H. García, Marín, J., Navarrete, J., Pelayo, J. Puerta, Verdugo, A., Corriveau, F., Freund, B., Chadeeva, M., Danilov, M., Gabriel, M., Emberger, L., Graf, C., Israeli, Y., Simon, F., Szalay, M., Windel, H., Bilokin, S., Bonis, J., Irles, A., Pöschl, R., Thiebault, A., Richard, F., Zerwas, D., Cvach, J., Janata, M., Kovalcuk, M., Polak, I., Smolik, J., Vrba, V., Zalesak, J., Zuklin, J., Takeshita, T., Elkhalii, A., Götze, M., Zeitnitz, C., Chang, S., Khan, A., Kim, D. H., Kong, D. J., and Oh, Y. D.

Subjects
Physics - Instrumentation and Detectors
Abstract

We present a study of the response of the highly granular Digital Hadronic Calorimeter with steel absorbers, the Fe-DHCAL, to positrons, muons, and pions with momenta ranging from 2 to 60 GeV/c. Developed in the context of the CALICE collaboration, this hadron calorimeter utilises Resistive Plate Chambers as active media, interspersed with steel absorber plates. With a transverse granularity of $1\,\times\,1\,$cm$^{2}$ and a longitudinal segmentation of 38 layers, the calorimeter counted 350,208 readout channels, each read out with single-bit resolution (digital readout). The data were recorded in the Fermilab test beam in 2010-11. The analysis includes measurements of the calorimeter response and the energy resolution to positrons and muons, as well as detailed studies of various shower shape quantities. The results are compared to simulations based on Geant4, which utilise different electromagnetic and hadronic physics lists.

Published
2019
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22. Detection of Pathogens and Antimicrobial Resistance Genes in Ventilator-Associated Pneumonia by Metagenomic Next-Generation Sequencing Approach

Author

Chen T, Zhang L, Huang W, Zong H, Li Q, Zheng Y, Lv Q, Kong D, Ren Y, Jiang Y, Li Y, and Liu P

Subjects
mechanical ventilation, endotracheal aspirate, pathogen diagnosis, antibiotic resistance, ngs, Infectious and parasitic diseases, RC109-216
Abstract

Ting Chen,1,2,&ast; Lei Zhang,3,&ast; Wenhua Huang,3,&ast; Huijun Zong,1,2 Qian Li,3 Yuling Zheng,3 Qingyu Lv,3 Decong Kong,3 Yuhao Ren,3 Yongqiang Jiang,3 Yan Li,1,2 Peng Liu3 1The PLA 307 Clinical College of Anhui Medical University, The Fifth Clinical Medical College of Anhui Medical University, Hefei, People’s Republic of China; 2Department of Critical Care Medicine, The Fifth Medical Center, Chinese PLA General Hospital, Beijing, 100071, People’s Republic of China; 3State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Yan Li, The PLA 307 Clinical College of Anhui Medical University, The Fifth Clinical Medical College of Anhui Medical University, Hefei, 230032, People’s Republic of China, Email liyanmdhuxi@163.com Peng Liu, Beijing Institute of Microbiology and Epidemiology, Dongdajie Road 20, Beijing, 100071, People’s Republic of China, Tel +86-010-66948487, Email ammsliupeng@163.comBackground: The early identification of pathogens and their antibiotic resistance are essential for the management and treatment of patients affected by ventilator-associated pneumonia (VAP). However, microbiological culture may be time-consuming and has a limited culturability of many potential pathogens. In this study, we developed a rapid nanopore-based metagenomic next-generation sequencing (mNGS) diagnostic assay for detection of VAP pathogens and antimicrobial resistance genes (ARGs).Patients and Methods: Endotracheal aspirate (ETA) samples from 63 patients with suspected VAP were collected between November 2021 and July 2022. Receiver operating characteristic (ROC) curves were established to compare the pathogen identification performance of the target pathogen reads, reads percent of microbes (RPM) and relative abundance (RA). The evaluation of the accuracy of mNGS was performed comparing with the gold standard and the composite standard, respectively. Then, the ARGs were analyzed by mNGS.Results: ROC curves showed that RA has the highest diagnostic value and the corresponding threshold was 9.93%. The sensitivity and specificity of mNGS test were 91.3% and 78.3%, respectively, based on the gold standard, while the sensitivity and specificity of mNGS test were 97.4% and 100%, respectively, based on the composite standard. A total of 13 patients were virus-positive based on mNGS results, while the coinfection rate increased from 27% to 46% compared to the rate obtained based on clinical findings. The mNGS test also performed well at predicting antimicrobial resistance phenotypes. Patients with a late-onset VAP had a significantly greater proportion of ARGs in their respiratory microbiome compared to those with early-onset VAP (P = 0.041). Moreover, the median turnaround time of mNGS was 4.43 h, while routine culture was 72.00 h.Conclusion: In this study, we developed a workflow that can accurately detect VAP pathogens and enable prediction of antimicrobial resistance phenotypes within 5 h of sample receipt by mNGS.Keywords: mechanical ventilation, endotracheal aspirate, pathogen diagnosis, antibiotic resistance, NGS

Published
2023

24. Semaglutide May Alleviate Hepatic Steatosis in T2DM Combined with NFALD Mice via miR-5120/ABHD6

Author

Li R, Ye Z, She D, Fang P, Zong G, Hu K, Kong D, Xu W, Li L, Zhou Y, Zhang K, and Xue Y

Subjects
semaglutide, non-alcoholic fatty liver disease, type 2 diabetes mellitus, α/β hydrolase domain-6, microrna-5120, Therapeutics. Pharmacology, RM1-950
Abstract

Ran Li,1 Zhengqin Ye,1 Dunmin She,2,3 Ping Fang,1 Guannan Zong,1 Kerong Hu,1 Dehong Kong,1 Wei Xu,1 Ling Li,1 Yun Zhou,1 Keqin Zhang,1 Ying Xue1 1Department of Endocrinology and Metabolism, Tongji Hospital, School of Medicine, Tongji University, Shanghai, People’s Republic of China; 2Clinical Medical College, Yangzhou University, Yangzhou, People’s Republic of China; 3Department of Endocrinology, Northern Jiangsu People’s Hospital Affiliated to Yangzhou University, Yangzhou, People’s Republic of ChinaCorrespondence: Ying Xue; Keqin Zhang, Department of Endocrinology and Metabolism, Tongji Hospital, School of Medicine, Tongji University, No. 389, Xincun Road, Shanghai, 200065, People’s Republic of China, Tel +86-021-66111061, Email doxy0622@163.com; keqzhang2018@163.comObjective: Although the pathogenesis of non-alcoholic fatty liver disease (NAFLD) has been extensively studied, the role of its underlying pathogenesis remains unclear, and there is currently no approved therapeutic strategy for NAFLD. The purpose of this study was to observe the beneficial effects of Semaglutide on NAFLD in vivo and in vitro, as well as its potential molecular mechanisms.Methods: Semaglutide was used to treat type 2 diabetes mellitus (T2DM) combined with NAFLD mice for 12 weeks. Hepatic function and structure were evaluated by liver function, blood lipids, liver lipids, H&E staining, oil red staining and Sirius staining. The expression of α/β hydrolase domain-6 (ABHD6) was measured by qPCR and Western blotting in vivo and in vitro. Then, dual-luciferase reporter assay was performed to verify the regulation of the upstream miR-5120 on ABHD6.Results: Our data revealed that Semaglutide administration significantly improved liver function and hepatic steatosis in T2DM combined with NAFLD mice. Furthermore, compared with controls, up-regulation of ABHD6 and down-regulation of miR-5120 were found in the liver of T2DM+NAFLD mice and HG+FFA-stimulated Hepa 1– 6 hepatocytes. Interestingly, after Semaglutide intervention, ABHD6 expression was significantly decreased in the liver of T2DM+NAFLD mice and in HG+FFA-stimulated Hepa 1– 6 hepatocytes, while miR-5120 expression was increased. We also found that miR-5120 could regulate the expression of ABHD6 in hepatocytes, while Semaglutide could modulate the expression of ABHD6 through miR-5120. In addition, GLP-1R was widely expressed in mouse liver tissues and Hepa 1– 6 cells. Semaglutide could regulate miR-5120/ABHD6 expression through GLP-1R.Conclusion: Our data revealed the underlying mechanism by which Semaglutide improves hepatic steatosis in T2DM+NAFLD, and might shed new light on the pathological role of miR-5120/ABHD6 in the pathogenesis of T2DM+NAFLD.Keywords: Semaglutide, non-alcoholic fatty liver disease, type 2 diabetes mellitus, α/β hydrolase domain-6, microRNA-5120

Published
2022

25. Hadronic Energy Resolution of a Combined High Granularity Scintillator Calorimeter System

Author

CALICE Collaboration, Repond, J., Xia, L., Apostolakis, J., Folger, G., Ivantchenko, V., Ribon, A., Uzhinskiy, V., Boumediene, D., Francais, V., Blazey, G. C., Dyshkant, A., Francis, K., Zutshi, V., Bach, O., Brianne, E., Ebrahimi, A., Gadow, K., Gttlicher, P., Krivan, O. Hartbrich F., Krüger, K., Kvasnicka, J., Lu, S., Neubüser, C., Provenza, A., Reinecke, M., Sefkow, F., Schuwalow, S., Sudo, Y., Tran, H. L., Buhmann, P., Garutti, E., Laurien, S., Lomidze, D., Matysek, M., Kaplan, A., Schultz-Coulon, H. -Ch., Wilson, G. W., Jeans, D., Kawagoe, K., Sekiya, I., Suehara, T., Yamashiro, H., Yoshioka, T., Wing, M., Kotera, K., Nishiyama, M., Sakuma, T., Takeshita, T., Tozuka, S., Tubokawa, T., Uozumi, S., Alamillo, E. Calvo, Fouz, M. C., Marin, J., Navarrete, J., Pelayo, J. Puerta, Verdugo, A., Chadeeva, M., Danilov, M., Drutskoy, A., Popova, E., Rusinov, V., Tarkovsky, E., Emberger, L., Gabriel, M., Graf, C., Israeli, Y., van der Kolk, N., Simon, F., Szalay, M., Windel, H., Bonis, S. Bilokin J., Pöschl, R., Irles, A., Thiebault, A., Richard, F., Zerwas, D., Anduze, M., Balagura, V., Becheva, E., Boudry, V., Brient, J-C., Cornat, R., Edy, E., Gastaldi, M. Frotin F., Li, B., Magniette, F., Nanni, J., Rubio-Roy, M., Shpak, K., Tran, T. H., Videau, H., Cvach, J., Janata, M., Kovalcuk, M., Polak, I., Smolik, J., Vrba, V., Zalesak, J., Zuklin, J., Chang, S., Khan, A., Kim, D. H., Kong, D. J., Oh, Y. D., Elkhalii, A., Götze, M., and Zeitnitz, C.

Subjects
Physics - Instrumentation and Detectors
Abstract

This paper presents results obtained with the combined CALICE Scintillator Electromagnetic Calorimeter, Analogue Hadronic Calorimeter and Tail Catcher & Muon Tracker, three high granularity scintillator-SiPM calorimeter prototypes. The response of the system to pions with momenta between 4 GeV/c and 32 GeV/c is analysed, including the energy response, resolution, and longitudinal shower profiles. The results of a software compensation technique based on weighting according to hit energy are compared to those of a standard linear energy reconstruction. The results are compared to predictions of the GEANT4 physics lists QGSP_BERT_HP and FTFP_BERT_HP., Comment: 31 pages, 41 figures

Published
2018

26. Measurement of the differential cross sections for $W$-boson production in association with jets in $p\bar{p}$ collisions at $\sqrt{s}=1.96$ TeV

Author

CDF Collaboration, Aaltonen, T., Amerio, S., Amidei, D., Anastassov, A., Annovi, A., Antos, J., Apollinari, G., Appel, J. A., Arisawa, T., Artikov, A., Asaadi, J., Ashmanskas, W., Auerbach, B., Aurisano, A., Azfar, F., Badgett, W., Bae, T., Barbaro-Galtieri, A., Barnes, V. E., Barnett, B. A., Barria, P., Bartos, P., Bauce, M., Bedeschi, F., Behari, S., Bellettini, G., Bellinger, J., Benjamin, D., Beretvas, A., Bhatti, A., Bland, K. R., Blumenfeld, B., Bocci, A., Bodek, A., Bortoletto, D., Boudreau, J., Boveia, A., Brigliadori, L., Bromberg, C., Brucken, E., Budagov, J., Budd, H. S., Burkett, K., Busetto, G., Bussey, P., Butti, P., Buzatu, A., Calamba, A., Camarda, S., Campanelli, M., Canelli, F., Carls, B., Carlsmith, D., Carosi, R., Carrillo, S., Casal, B., Casarsa, M., Castro, A., Catastini, P., Cauz, D., Cavaliere, V., Cerri, A., Cerrito, L., Chen, Y. C., Chertok, M., Chiarelli, G., Chlachidze, G., Cho, K., Chokheli, D., Clark, A., Clarke, C., Convery, M. E., Conway, J., Corbo, M., Cordelli, M., Cox, C. A., Cox, D. J., Cremonesi, M., Cruz, D., Cuevas, J., Culbertson, R., d'Ascenzo, N., Datta, M., de Barbaro, P., Demortier, L., Deninno, M., Devoto, F., D'Errico, M., Di Canto, A., Di Ruzza, B., Dittmann, J. R., D'Onofrio, M., Donati, S., Dorigo, M., Driutti, A., Ebina, K., Edgar, R., Elagin, A., Erbacher, R., Errede, S., Esham, B., Farrington, S., Ramos, J. P. Fernández, Field, R., Flanagan, G., Forrest, R., Franklin, M., Freeman, J. C., Frisch, H., Funakoshi, Y., Galloni, C., Garfinkel, A. F., Garosi, P., Gerberich, H., Gerchtein, E., Giagu, S., Giakoumopoulou, V., Gibson, K., Ginsburg, C. M., Giokaris, N., Giromini, P., Glagolev, V., Glenzinski, D., Gold, M., Goldin, D., Golossanov, A., Gomez, G., Gomez-Ceballos, G., Goncharov, M., López, O. González, Gorelov, I., Goshaw, A. T., Goulianos, K., Gramellini, E., Grosso-Pilcher, C., da Costa, J. Guimaraes, Hahn, S. R., Han, J. Y., Happacher, F., Hara, K., Hare, M., Harr, R. F., Harrington-Taber, T., Hatakeyama, K., Hays, C., Heinrich, J., Herndon, M., Hocker, A., Hong, Z., Hopkins, W., Hou, S., Hughes, R. E., Husemann, U., Hussein, M., Huston, J., Introzzi, G., Iori, M., Ivanov, A., James, E., Jang, D., Jayatilaka, B., Jeon, E. J., Jindariani, S., Jones, M., Joo, K. K., Jun, S. Y., Junk, T. R., Kambeitz, M., Kamon, T., Karchin, P. E., Kasmi, A., Kato, Y., Ketchum, W., Keung, J., Kilminster, B., Kim, D. H., Kim, H. S., Kim, J. E., Kim, M. J., Kim, S. B., Kim, S. H., Kim, Y. K., Kim, Y. J., Kimura, N., Kirby, M., Kondo, K., Kong, D. J., Konigsberg, J., Kotwal, A. V., Kreps, M., Kroll, J., Kruse, M., Kuhr, T., Kurata, M., Laasanen, A. T., Lammel, S., Lancaster, M., Lannon, K., Latino, G., Lee, H. S., Lee, J. S., Leo, S., Leone, S., Lewis, J. D., Limosani, A., Lipeles, E., Lister, A., Liu, Q., Liu, T., Lockwitz, S., Loginov, A., Lucà, A., Lucchesi, D., Lueck, J., Lujan, P., Lukens, P., Lungu, G., Lys, J., Lysak, R., Madrak, R., Maestro, P., Malik, S., Manca, G., Manousakis-Katsikakis, A., Marchese, L., Margaroli, F., Marino, P., Matera, K., Mattson, M. E., Mazzacane, A., Mazzanti, P., McNulty, R., Mehta, A., Mehtala, P., Mesropian, C., Miao, T., Michielin, E., Mietlicki, D., Mitra, A., Miyake, H., Moed, S., Moggi, N., Moon, C. S., Moore, R., Morello, M. J., Mukherjee, A., Muller, Th., Murat, P., Mussini, M., Nachtman, J., Nagai, Y., Naganoma, J., Nakano, I., Napier, A., Nett, J., Nigmanov, T., Nodulman, L., Noh, S. Y., Norniella, O., Oakes, L., Oh, S. H., Oh, Y. D., Okusawa, T., Orava, R., Ortolan, L., Pagliarone, C., Palencia, E., Palni, P., Papadimitriou, V., Parker, W., Pauletta, G., Paulini, M., Paus, C., Phillips, T. J., Piacentino, G., Pianori, E., Pilot, J., Pitts, K., Plager, C., Pondrom, L., Poprocki, S., Potamianos, K., Prokoshin, F., Pranko, A., Ptohos, F., Punzi, G., Fernández, I. Redondo, Renton, P., Rescigno, M., Rimondi, F., Ristori, L., Robson, A., Rodriguez, T., Rolli, S., Ronzani, M., Roser, R., Rosner, J. L., Ruffini, F., Ruiz, A., Russ, J., Rusu, V., Sakumoto, W. K., Sakurai, Y., Santi, L., Sato, K., Saveliev, V., Savoy-Navarro, A., Schlabach, P., Schmidt, E. E., Schwarz, T., Scodellaro, L., Scuri, F., Seidel, S., Seiya, Y., Semenov, A., Sforza, F., Shalhout, S. Z., Shears, T., Shepard, P. F., Shimojima, M., Shochet, M., Shreyber-Tecker, I., Simonenko, A., Sliwa, K., Smith, J. R., Snider, F. D., Sorin, V., Song, H., Stancari, M., Denis, R. St., Stentz, D., Strologas, J., Sudo, Y., Sukhanov, A., Suslov, I., Takemasa, K., Takeuchi, Y., Tang, J., Tecchio, M., Teng, P. K., Thom, J., Thomson, E., Thukral, V., Toback, D., Tokar, S., Tollefson, K., Tomura, T., Tonelli, D., Torre, S., Torretta, D., Totaro, P., Trovato, M., Ukegawa, F., Uozumi, S., Vázquez, F., Velev, G., Vellidis, C., Vernieri, C., Vidal, M., Vilar, R., Vizán, J., Vogel, M., Volpi, G., Wagner, P., Wallny, R., Wang, S. M., Waters, D., Wester III, W. C., Whiteson, D., Wicklund, A. B., Wilbur, S., Williams, H. H., Wilson, J. S., Wilson, P., Winer, B. L., Wittich, P., Wolbers, S., Wolfmeister, H., Wright, T., Wu, X., Wu, Z., Yamamoto, K., Yamato, D., Yang, T., Yang, U. K., Yang, Y. C., Yao, W. -M., Yeh, G. P., Yi, K., Yoh, J., Yorita, K., Yoshida, T., Yu, G. B., Yu, I., Zanetti, A. M., Zeng, Y., Zhou, C., and Zucchelli, S.

Subjects
High Energy Physics - Experiment
Abstract

This paper presents a study of the production of a single $W$ boson in association with one or more jets in proton-antiproton collisions at $\sqrt{s}=1.96$ TeV, using the entire data set collected in 2001-2011 by the Collider Detector at Fermilab at the Tevatron, which corresponds to an integrated luminosity of $9.0$ fb$^{-1}$. The $W$ boson is identified through its leptonic decays into electron and muon. The production cross sections are measured for each leptonic decay mode and combined after testing that the ratio of the $W(\rightarrow \mu\nu)+$jets cross section to the $W(\rightarrow e\nu)+$jets cross section agrees with the hypothesis of $e$-$\mu$ lepton universality. The combination of measured cross sections, differential in the inclusive jet multiplicity ($W+\geqslant N$ jets with $N=1,\,2,\,3, \textrm{or }4$) and in the transverse energy of the leading jet, are compared with theoretical predictions., Comment: submitted to Phys. Rev. D

Published
2018
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27. Search for standard-model Z and Higgs bosons decaying into a bottom-antibottom quark pair in proton-antiproton collisions at 1.96 TeV

Author

CDF Collaboration, Aaltonen, T., Amerio, S., Amidei, D., Anastassov, A., Annovi, A., Antos, J., Apollinari, G., Appel, J. A., Arisawa, T., Artikov, A., Asaadi, J., Ashmanskas, W., Auerbach, B., Aurisano, A., Azfar, F., Badgett, W., Bae, T., Barbaro-Galtieri, A., Barnes, V. E., Barnett, B. A., Barria, P., Bartos, P., Bauce, M., Bedeschi, F., Behari, S., Bellettini, G., Bellinger, J., Benjamin, D., Beretvas, A., Bhatti, A., Bland, K. R., Blumenfeld, B., Bocci, A., Bodek, A., Bortoletto, D., Boudreau, J., Boveia, A., Brigliadori, L., Bromberg, C., Brucken, E., Budagov, J., Budd, H. S., Burkett, K., Busetto, G., Bussey, P., Butti, P., Buzatu, A., Calamba, A., Camarda, S., Campanelli, M., Canelli, F., Carls, B., Carlsmith, D., Carosi, R., Carrillo, S., Casal, B., Casarsa, M., Castro, A., Catastini, P., Cauz, D., Cavaliere, V., Cerri, A., Cerrito, L., Chen, Y. C., Chertok, M., Chiarelli, G., Chlachidze, G., Cho, K., Chokheli, D., Clark, A., Clarke, C., Convery, M. E., Conway, J., Corbo, M., Cordelli, M., Cox, C. A., Cox, D. J., Cremonesi, M., Cruz, D., Cuevas, J., Culbertson, R., d'Ascenzo, N., Datta, M., de Barbaro, P., Demortier, L., Deninno, M., Devoto, F., D'Errico, M., Di Canto, A., Di Ruzza, B., Dittmann, J. R., D'Onofrio, M., Donati, S., Dorigo, M., Driutti, A., Ebina, K., Edgar, R., Elagin, A., Erbacher, R., Errede, S., Esham, B., Farrington, S., Ramos, J. P. Fernández, Field, R., Flanagan, G., Forrest, R., Franklin, M., Freeman, J. C., Frisch, H., Funakoshi, Y., Galloni, C., Garfinkel, A. F., Garosi, P., Gerberich, H., Gerchtein, E., Giagu, S., Giakoumopoulou, V., Gibson, K., Ginsburg, C. M., Giokaris, N., Giromini, P., Glagolev, V., Glenzinski, D., Gold, M., Goldin, D., Golossanov, A., Gomez, G., Gomez-Ceballos, G., Goncharov, M., López, O. González, Gorelov, I., Goshaw, A. T., Goulianos, K., Gramellini, E., Grosso-Pilcher, C., da Costa, J. Guimaraes, Hahn, S. R., Han, J. Y., Happacher, F., Hara, K., Hare, M., Harr, R. F., Harrington-Taber, T., Hatakeyama, K., Hays, C., Heinrich, J., Herndon, M., Hocker, A., Hong, Z., Hopkins, W., Hou, S., Hughes, R. E., Husemann, U., Hussein, M., Huston, J., Introzzi, G., Iori, M., Ivanov, A., James, E., Jang, D., Jayatilaka, B., Jeon, E. J., Jindariani, S., Jones, M., Joo, K. K., Jun, S. Y., Junk, T. R., Kambeitz, M., Kamon, T., Karchin, P. E., Kasmi, A., Kato, Y., Ketchum, W., Keung, J., Kilminster, B., Kim, D. H., Kim, H. S., Kim, J. E., Kim, M. J., Kim, S. B., Kim, S. H., Kim, Y. K., Kim, Y. J., Kimura, N., Kirby, M., Kondo, K., Kong, D. J., Konigsberg, J., Kotwal, A. V., Kreps, M., Kroll, J., Kruse, M., Kuhr, T., Kurata, M., Laasanen, A. T., Lammel, S., Lancaster, M., Lannon, K., Latino, G., Lee, H. S., Lee, J. S., Leo, S., Leone, S., Lewis, J. D., Limosani, A., Lipeles, E., Lister, A., Liu, Q., Liu, T., Lockwitz, S., Loginov, A., Lucà, A., Lucchesi, D., Lueck, J., Lujan, P., Lukens, P., Lungu, G., Lys, J., Lysak, R., Madrak, R., Maestro, P., Malik, S., Manca, G., Manousakis-Katsikakis, A., Marchese, L., Margaroli, F., Marino, P., Matera, K., Mattson, M. E., Mazzacane, A., Mazzanti, P., McNulty, R., Mehta, A., Mehtala, P., Mesropian, C., Miao, T., Michielin, E., Mietlicki, D., Mitra, A., Miyake, H., Moed, S., Moggi, N., Moon, C. S., Moore, R., Morello, M. J., Mukherjee, A., Muller, Th., Murat, P., Mussini, M., Nachtman, J., Nagai, Y., Naganoma, J., Nakano, I., Napier, A., Nett, J., Nigmanov, T., Nodulman, L., Noh, S. Y., Norniella, O., Oakes, L., Oh, S. H., Oh, Y. D., Okusawa, T., Orava, R., Ortolan, L., Pagliarone, C., Palencia, E., Palni, P., Papadimitriou, V., Parker, W., Pauletta, G., Paulini, M., Paus, C., Phillips, T. J., Piacentino, G., Pianori, E., Pilot, J., Pitts, K., Plager, C., Pondrom, L., Poprocki, S., Potamianos, K., Prokoshin, F., Pranko, A., Ptohos, F., Punzi, G., Fernández, I. Redondo, Renton, P., Rescigno, M., Rimondi, F., Ristori, L., Robson, A., Rodriguez, T., Rolli, S., Ronzani, M., Roser, R., Rosner, J. L., Ruffini, F., Ruiz, A., Russ, J., Rusu, V., Sakumoto, W. K., Sakurai, Y., Santi, L., Sato, K., Saveliev, V., Savoy-Navarro, A., Schlabach, P., Schmidt, E. E., Schwarz, T., Scodellaro, L., Scuri, F., Seidel, S., Seiya, Y., Semenov, A., Sforza, F., Shalhout, S. Z., Shears, T., Shepard, P. F., Shimojima, M., Shochet, M., Shreyber-Tecker, I., Simonenko, A., Sliwa, K., Smith, J. R., Snider, F. D., Sorin, V., Song, H., Stancari, M., Denis, R. St., Stentz, D., Strologas, J., Sudo, Y., Sukhanov, A., Suslov, I., Takemasa, K., Takeuchi, Y., Tang, J., Tecchio, M., Teng, P. K., Thom, J., Thomson, E., Thukral, V., Toback, D., Tokar, S., Tollefson, K., Tomura, T., Tonelli, D., Torre, S., Torretta, D., Totaro, P., Trovato, M., Ukegawa, F., Uozumi, S., Vázquez, F., Velev, G., Vellidis, C., Vernieri, C., Vidal, M., Vilar, R., Vizán, J., Vogel, M., Volpi, G., Wagner, P., Wallny, R., Wang, S. M., Waters, D., Wester III, W. C., Whiteson, D., Wicklund, A. B., Wilbur, S., Williams, H. H., Wilson, J. S., Wilson, P., Winer, B. L., Wittich, P., Wolbers, S., Wolfmeister, H., Wright, T., Wu, X., Wu, Z., Yamamoto, K., Yamato, D., Yang, T., Yang, U. K., Yang, Y. C., Yao, W. -M., Yeh, G. P., Yi, K., Yoh, J., Yorita, K., Yoshida, T., Yu, G. B., Yu, I., Zanetti, A. M., Zeng, Y., Zhou, C., and Zucchelli, S.

Subjects
High Energy Physics - Experiment
Abstract

The Collider Detector at Fermilab collected a unique sample of jets originating from bottom-quark fragmentation ($b$-jets) by selecting online proton-antiproton ($p\bar{p}$) collisions with a vertex displaced from the $p\bar{p}$ interaction point, consistent with the decay of a bottom-quark hadron. This data set, collected at a center-of-mass energy of $\sqrt{s}=$1.96 TeV, and corresponding to an integrated luminosity of $5.4~\rm{fb}^{-1}$, is used to measure the $Z$-boson production cross section times branching ratio into $b\bar{b}$. The number of $Z\rightarrow b\bar{b}$ events is determined by fitting the dijet-mass distribution while constraining the dominant $b$-jet background, originating from QCD multijet events, with data. The result, $\sigma(p\bar{p} \rightarrow Z) \times \mathcal{B}(Z \rightarrow b\bar{b})= 1.11\pm 0.08(\text{stat}) \pm 0.14(\text{syst})~\text{nb}$, is the most precise measurement of this process, and is consistent with the standard-model prediction. The data set is also used to search for Higgs-boson production. No significant signal is expected in our data and the first upper limit on the cross section for the inclusive $p\bar p \rightarrow H\rightarrow b\bar b$ process at $\sqrt{s}=$1.96 TeV is set, corresponding to 33 times the expected standard-model cross section, or $\sigma = 40.6$ pb, at the 95\% confidence level.

Published
2018
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28. Modulations of the Surface Magnetic Field on the Intra-cycle Variability of Total Solar Irradiance

Author

Xu, J. C., Kong, D. F., and Li, F. Y.

Subjects
Astrophysics - Solar and Stellar Astrophysics
Abstract

Solar photospheric magnetic field plays a dominant role in the variability of total solar irradiance (TSI). The modulation of magnetic flux at six specific ranges on TSI is characterized for the first time. The daily flux values of magnetic field at four ranges are extracted from MDI/{\sl SOHO}, together with daily flux of active regions (MF$_{\text{ar}}$) and quiet regions (MF$_{\text{qr}}$); the first four ranges (MF$_{1-4}$) are: 1.5--2.9, 2.9--32.0, 32.0--42.7, and 42.7--380.1 ($\times 10^{18}$ Mx per element), respectively. Cross-correlograms show that MF$_4$, MF$_{\text{qr}}$, and MF$_{\text{ar}}$ are positively correlated with TSI, while MF$_2$ is negatively correlated with TSI; the correlations between MF$_1$, MF$_3$ and TSI are insignificant. The bootstrapping tests confirm that the impact of MF$_4$ on TSI is more significant than that of MF$_{\text{ar}}$ and MF$_{\text{qr}}$, and MF$_{\text{ar}}$ leads TSI by one rotational period. By extracting the rotational variations in the MFs and TSI, the modulations of the former on the latter at the solar rotational timescale are clearly illustrated and compared during solar maximum and minimum times, respectively. Comparison of the relative amplitudes of the long-term variation show that TSI is in good agreement with the variation of MF$_4$ and MF$_{\text{ar}}$; besides, MF$_2$ is in antiphase with TSI, and it lags the latter by about 1.5 years., Comment: 13 pages, 12 figures; accepted by Astrophysics and Space Science

Published
2018
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29. Simultaneous observation of a flux rope eruption and magnetic reconnection during an X-class solar flare

Author

Yan, X. L., Yang, L. H., Xue, Z. K., Mei, Z. X., Kong, D. F., Wang, J. C., and Li, Q. L.

Subjects
Astrophysics - Solar and Stellar Astrophysics
Abstract

In this letter, we present a spectacular eruptive flare (X8.2) associated with a coronal mass ejection (CME) on 2017 September 10 at the west limb of the Sun. A flux rope eruption is followed by the inflow, the formation of a current sheet and a cusp structure, which were simultaneously observed during the occurrence of this flare. The hierarchical layers of the cusp-shaped structure are well observed in 131 \AA\ observation. The scenario that can be created from these observations is very consistent with the predictions of some eruptive models. Except for the characteristics mentioned above in the process of the flare predicted by classical eruption models, the current sheet separating into several small current sheets is also observed at the final stage of the flux rope eruption. The quantitative calculation of the velocities and accelerations of the inflow, hot cusp structure, and post-flare loops is presented. The width of the current sheet is estimated to be about 3 $\times$ $10^{3}$ km. These observations are very useful to understand the process of solar eruptions., Comment: 16 pages, 5 figures, accepted for publication in ApJL

Published
2018
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30. Successive X-class flares and coronal mass ejections driven by shearing motion and sunspot rotation in active region NOAA 12673

Author

Yan, X. L., Wang, J. C., Pan, G. M., Kong, D. F., Xue, Z. K., Yang, L. H., Li, Q. L., and Feng, X. S.

Subjects
Astrophysics - Solar and Stellar Astrophysics
Abstract

We present a clear case study on the occurrence of two successive X-class flares including a decade-class flare (X9.3) and two coronal mass ejections (CMEs) triggered by shearing motion and sunspot rotation in active region NOAA 12673 on 2017 September 6. A shearing motion between the main sunspots with opposite polarities started on September 5 and even lasted after the second X-class flare on September 6. Moreover, the main sunspot with negative polarity rotated around its umbral center and another main sunspot with positive polarity also exhibited a slow rotation. The sunspot with negative polarity at the northwest of active region also began to rotate counter-clockwise before the onset of the first X-class flare. The successive formation and eruption of two S-shaped structures were closely related to the counter-clockwise rotation of three sunspots. It is also found that the rotation of sunspots is faster during four hours prior to the onset of the flares than the period before. The existence of a flux rope is found prior to the onset of two flares by using non-linear force free field extrapolation based on the vector magnetograms observed by SDO/HMI. These results suggest that shearing motion and sunspot rotation play an important role in the buildup of the free energy and the formation of flux ropes in the corona which produces solar flares and CMEs., Comment: 28 pages, 12 figures, ApJ

Published
2018
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31. A search for the exotic meson $X(5568)$ with the Collider Detector at Fermilab

Author

CDF Collaboration, Aaltonen, T., Amerio, S., Amidei, D., Anastassov, A., Annovi, A., Antos, J., Apollinari, G., Appel, J. A., Arisawa, T., Artikov, A., Asaadi, J., Ashmanskas, W., Auerbach, B., Aurisano, A., Azfar, F., Badgett, W., Bae, T., Barbaro-Galtieri, A., Barnes, V. E., Barnett, B. A., Barria, P., Bartos, P., Bauce, M., Bedeschi, F., Behari, S., Bellettini, G., Bellinger, J., Benjamin, D., Beretvas, A., Bhatti, A., Bland, K. R., Blumenfeld, B., Bocci, A., Bodek, A., Bortoletto, D., Boudreau, J., Boveia, A., Brigliadori, L., Bromberg, C., Brucken, E., Budagov, J., Budd, H. S., Burkett, K., Busetto, G., Bussey, P., Butti, P., Buzatu, A., Calamba, A., Camarda, S., Campanelli, M., Canelli, F., Carls, B., Carlsmith, D., Carosi, R., Carrillo, S., Casal, B., Casarsa, M., Castro, A., Catastini, P., Cauz, D., Cavaliere, V., Cerri, A., Cerrito, L., Chen, Y. C., Chertok, M., Chiarelli, G., Chlachidze, G., Cho, K., Chokheli, D., Clark, A., Clarke, C., Convery, M. E., Conway, J., Corbo, M., Cordelli, M., Cox, C. A., Cox, D. J., Cremonesi, M., Cruz, D., Cuevas, J., Culbertson, R., d'Ascenzo, N., Datta, M., de Barbaro, P., Demortier, L., Deninno, M., Devoto, F., D'Errico, M., Di Canto, A., Di Ruzza, B., Dittmann, J. R., D'Onofrio, M., Donati, S., Dorigo, M., Driutti, A., Ebina, K., Edgar, R., Elagin, A., Erbacher, R., Errede, S., Esham, B., Farrington, S., Ramos, J. P. Fernández, Field, R., Flanagan, G., Forrest, R., Franklin, M., Freeman, J. C., Frisch, H., Funakoshi, Y., Galloni, C., Garfinkel, A. F., Garosi, P., Gerberich, H., Gerchtein, E., Giagu, S., Giakoumopoulou, V., Gibson, K., Ginsburg, C. M., Giokaris, N., Giromini, P., Glagolev, V., Glenzinski, D., Gold, M., Goldin, D., Golossanov, A., Gomez, G., Gomez-Ceballos, G., Goncharov, M., López, O. González, Gorelov, I., Goshaw, A. T., Goulianos, K., Gramellini, E., Grosso-Pilcher, C., da Costa, J. Guimaraes, Hahn, S. R., Han, J. Y., Happacher, F., Hara, K., Hare, M., Harr, R. F., Harrington-Taber, T., Hatakeyama, K., Hays, C., Heinrich, J., Herndon, M., Hocker, A., Hong, Z., Hopkins, W., Hou, S., Hughes, R. E., Husemann, U., Hussein, M., Huston, J., Introzzi, G., Iori, M., Ivanov, A., James, E., Jang, D., Jayatilaka, B., Jeon, E. J., Jindariani, S., Jones, M., Joo, K. K., Jun, S. Y., Junk, T. R., Kambeitz, M., Kamon, T., Karchin, P. E., Kasmi, A., Kato, Y., Ketchum, W., Keung, J., Kilminster, B., Kim, D. H., Kim, H. S., Kim, J. E., Kim, M. J., Kim, S. B., Kim, S. H., Kim, Y. K., Kim, Y. J., Kimura, N., Kirby, M., Kondo, K., Kong, D. J., Konigsberg, J., Kotwal, A. V., Kreps, M., Kroll, J., Kruse, M., Kuhr, T., Kurata, M., Laasanen, A. T., Lammel, S., Lancaster, M., Lannon, K., Latino, G., Lee, H. S., Lee, J. S., Leo, S., Leone, S., Lewis, J. D., Limosani, A., Lipeles, E., Lister, A., Liu, Q., Liu, T., Lockwitz, S., Loginov, A., Lucà, A., Lucchesi, D., Lueck, J., Lujan, P., Lukens, P., Lungu, G., Lys, J., Lysak, R., Madrak, R., Maestro, P., Malik, S., Manca, G., Manousakis-Katsikakis, A., Marchese, L., Margaroli, F., Marino, P., Matera, K., Mattson, M. E., Mazzacane, A., Mazzanti, P., McNulty, R., Mehta, A., Mehtala, P., Mesropian, C., Miao, T., Mietlicki, D., Mitra, A., Miyake, H., Moed, S., Moggi, N., Moon, C. S., Moore, R., Morello, M. J., Mukherjee, A., Muller, Th., Murat, P., Mussini, M., Nachtman, J., Nagai, Y., Naganoma, J., Nakano, I., Napier, A., Nett, J., Nigmanov, T., Nodulman, L., Noh, S. Y., Norniella, O., Oakes, L., Oh, S. H., Oh, Y. D., Okusawa, T., Orava, R., Ortolan, L., Pagliarone, C., Palencia, E., Palni, P., Papadimitriou, V., Parker, W., Pauletta, G., Paulini, M., Paus, C., Phillips, T. J., Piacentino, G., Pianori, E., Pilot, J., Pitts, K., Plager, C., Pondrom, L., Poprocki, S., Potamianos, K., Prokoshin, F., Pranko, A., Ptohos, F., Punzi, G., Fernández, I. Redondo, Renton, P., Rescigno, M., Rimondi, F., Ristori, L., Robson, A., Rodriguez, T., Rolli, S., Ronzani, M., Roser, R., Rosner, J. L., Ruffini, F., Ruiz, A., Russ, J., Rusu, V., Sakumoto, W. K., Sakurai, Y., Santi, L., Sato, K., Saveliev, V., Savoy-Navarro, A., Schlabach, P., Schmidt, E. E., Schwarz, T., Scodellaro, L., Scuri, F., Seidel, S., Seiya, Y., Semenov, A., Sforza, F., Shalhout, S. Z., Shears, T., Shepard, P. F., Shimojima, M., Shochet, M., Shreyber-Tecker, I., Simonenko, A., Sliwa, K., Smith, J. R., Snider, F. D., Sorin, V., Song, H., Stancari, M., Denis, R. St., Stentz, D., Strologas, J., Sudo, Y., Sukhanov, A., Suslov, I., Takemasa, K., Takeuchi, Y., Tang, J., Tecchio, M., Teng, P. K., Thom, J., Thomson, E., Thukral, V., Toback, D., Tokar, S., Tollefson, K., Tomura, T., Tonelli, D., Torre, S., Torretta, D., Totaro, P., Trovato, M., Ukegawa, F., Uozumi, S., Vázquez, F., Velev, G., Vellidis, C., Vernieri, C., Vidal, M., Vilar, R., Vizán, J., Vogel, M., Volpi, G., Wagner, P., Wallny, R., Wang, S. M., Waters, D., Wester III, W. C., Whiteson, D., Wicklund, A. B., Wilbur, S., Williams, H. H., Wilson, J. S., Wilson, P., Winer, B. L., Wittich, P., Wolbers, S., Wolfmeister, H., Wright, T., Wu, X., Wu, Z., Yamamoto, K., Yamato, D., Yang, T., Yang, U. K., Yang, Y. C., Yao, W. -M., Yeh, G. P., Yi, K., Yoh, J., Yorita, K., Yoshida, T., Yu, G. B., Yu, I., Zanetti, A. M., Zeng, Y., Zhou, C., and Zucchelli, S.

Subjects
High Energy Physics - Experiment
Abstract

A search for the exotic meson $X(5568)$ decaying into the $B^0_s \pi^{\pm}$ final state is performed using data corresponding to $9.6 \textrm{fb}^{-1}$ from $p{\bar p}$ collisions at $\sqrt{s} = 1960$ GeV recorded by the Collider Detector at Fermilab. No evidence for this state is found and an upper limit of 6.7\% at the 95\% confidence level is set on the fraction of $B^0_s$ produced through the $X(5568) \rightarrow B^0_s \, \pi^{\pm}$ process., Comment: 13 pages, 3 figures

Published
2017
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32. The Double-Edged Sword of Underdog Expectations in Organizations in Shanghai, China: The Mediating Role of Feedback-Avoiding Behaviors and Proving Others Wrong and the Moderating Role of Regulatory Focus

Author

Xue J, Zhu M, Guo Y, and Kong D

Subjects
underdog expectations, regulatory focus theory, prove others wrong, feedback-avoiding behaviors, Psychology, BF1-990, Industrial psychology, HF5548.7-5548.85
Abstract

Jinli Xue,1 Mengting Zhu,2 Yanan Guo,3 Demin Kong4 1Research Center for Energy Economics, School of Business Administration, Henan Polytechnic University, Jiaozuo, People’s Republic of China; 2School of Management, Shanghai University, Shanghai, People’s Republic of China; 3School of Financial Management, Zhejiang Financial College, Hangzhou, People’s Republic of China; 4School of Humanities, Shanghai University of Finance and Economics, Shanghai, People’s Republic of ChinaCorrespondence: Mengting Zhu, School of Management, Shanghai University, Shanghai, People’s Republic of China, Tel +86-18682641363, Email jocelemy@163.comPurpose: According to the traditional view, “underdog expectations” induce self-doubt in employees, resulting in negative effects. However, a new study suggests that underdog expectations may encourage employees to work harder, resulting in positive effects. Based on regulatory focus theory, this study constructed a moderated double-mediation model to explain the “double-edged sword effect” of underdog expectations.Subjects and Methods: A three-wave survey method and leader–employee pairing method were used to conduct a questionnaire survey among 346 employees drawn from five enterprises in Shanghai, China. Statistical analysis methods, including hierarchical regression analysis, simple slope analysis, and difference analysis, were used for data analysis. SPSS 24.0, Amoss 24.0, and Mplus 7.4 software were employed to test four proposed hypotheses.Results: Under the positive moderating effect of prevention focus, underdog expectations reduce employee work engagement by adopting an avoidance path of employee feedback-avoiding behaviors(β = 0.090, p < 0.01). Moreover, underdog expectations play a negative role in this situation . Under the positive moderating effect of promotion focus, underdog expectations improve employee work engagement by adopting an approach of proving others wrong (β = 0.189, p < 0.001). Moreover, underdog expectations play a positive role in this situation.Conclusion: The study results refined the double-sided effects of underdog expectations on employee work engagement and provided theoretical and practical implications for managers on how to motivate employees with underdog expectations and how to better convey expectations to subordinates.Keywords: underdog expectations, regulatory focus theory, prove others wrong, feedback-avoiding behaviors

Published
2022

33. Transcriptomic Profiling Reveals Underlying Immunoregulation Mechanisms of Resistant Hypertension in Injection Drug Users

Author

Jia J, Yang JQ, Du YR, Xu Y, Kong D, Zhang XL, Mao JH, Hu GF, Wang KH, and Kuang YQ

Subjects
drug use, hypertension, treatment-resistant, transcriptome, immunoregulation, Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950
Abstract

Jie Jia,1,2 Ji-Qun Yang,3 Ying-Rong Du,3 Yu Xu,2 Deshenyue Kong,1,2 Xiu-Ling Zhang,3 Jun-Hong Mao,1,2 Gui-Fang Hu,3 Kun-Hua Wang,1,2,4 Yi-Qun Kuang1,2 1NHC Key Laboratory of Drug Addiction Medicine, First Affiliated Hospital of Kunming Medical University, Kunming Medical University, Kunming, 650032, People’s Republic of China; 2Scientific Research Laboratory Center, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, People’s Republic of China; 3Third People’s Hospital of Kunming City/Drug Rehabilitation Hospital of Kunming City, Kunming, 650041, People’s Republic of China; 4School of Medicine, Yunnan University, Kunming, 650500, People’s Republic of ChinaCorrespondence: Yi-Qun Kuang; Kun-Hua Wang, NHC Key Laboratory of Drug Addiction Medicine, First Affiliated Hospital of Kunming Medical University, Kunming Medical University, Kunming, 650032, People’s Republic of China, Email yq610433@hotmail.com; wangkunhua1964@126.comBackground: Hypertension is a common complication in injection drug users (IDU), especially a high proportion of resistant hypertension occurs among them. However, the involving mechanisms remain largely unknown.Methods: We here investigated the key signaling moieties in resistant hypertension in drug users. Analyses were performed with high-throughput transcriptomic sequencing data of peripheral blood from individuals with drug-sensitive hypertension (Ctrl-DS), IDU with resistant hypertension (IDU-DR), and IDU with sensitive hypertension (IDU-DS).Results: We showed that 17 and 1 genes in IDU-DS, 48 and 4 genes in IDU-DR were upregulated and downregulated compared Ctrl-DS, and 2 and 4 genes were upregulated and downregulated in IDU-DR compared with IDU-DS, respectively (p ≤ 0.01 and |log2(FC)| ≥ 1). Differentially expressed genes (DEGs) between Ctrl-DS and IDU-DS were mainly involved in Gene ontology terms of immunoglobulin complex and blood microparticle. DEGs between IDU-DS and IDU-DR were mainly involved in immune system process and immunoglobulin complex. DEGs between Ctrl-DS and IDU-DR were mainly involved in immunoglobulin complex, blood microparticle and cytoplasmic vesicle lumen. We identified 2 gene clusters (brown modules, MEbrown; turquoise module, MEturquoise) correlated with IDU-DR and a gene cluster (magenta module, MEmagenta) correlated with IDU-DS by weighted gene co-expression network analysis (WGCNA). Functional analysis demonstrated that pathways of focal adhesion and focalin-1-rich granule lumen were involved in the development of IDU-DR, and the cytosolic large ribosomal subunit may relate to IDU-DR. Further, immune cell infiltration analysis demonstrated that the abundance of dendritic cells (DCs), natural Treg cells (nTreg), and exhausted T cells (Tex) in IDU-DR and IDU-DS, naïve CD8+ T cells in IDU-DS was significantly different compared with that in Ctrl-DS. The abundance of cytotoxic T cells (Tc) was significantly different between IDU-DS and IDU-DR.Conclusion: Our findings indicated a potential function of immunoregulation mechanisms for resistant hypertension.Keywords: drug use, hypertension, treatment-resistant, transcriptome, immunoregulation

Published
2022

35. Erratum to: Searches for long-lived charged particles in pp collisions at s = 7 and 8 TeV

Author

Chatrchyan, S., Khachatryan, V., Sirunyan, A. M., Tumasyan, A., Adam, W., Bergauer, T., Dragicevic, M., Erö, J., Fabjan, C., Friedl, M., Frühwirth, R., Ghete, V. M., Hörmann, N., Hrubec, J., Jeitler, M., Kiesenhofer, W., Knünz, V., Krammer, M., Krätschmer, I., Liko, D., Mikulec, I., Rabady, D., Rahbaran, B., Rohringer, C., Rohringer, H., Schöfbeck, R., Strauss, J., Taurok, A., Treberer-Treberspurg, W., Waltenberger, W., Wulz, C.-E., Mossolov, V., Shumeiko, N., Suarez Gonzalez, J., Alderweireldt, S., Bansal, M., Bansal, S., Cornelis, T., De Wolf, E. A., Janssen, X., Knutsson, A., Luyckx, S., Mucibello, L., Ochesanu, S., Roland, B., Rougny, R., Van Haevermaet, H., Van Mechelen, P., Van Remortel, N., Van Spilbeeck, A., Blekman, F., Blyweert, S., D’Hondt, J., Kalogeropoulos, A., Keaveney, J., Maes, M., Olbrechts, A., Tavernier, S., Van Doninck, W., Van Mulders, P., Van Onsem, G. P., Villella, I., Clerbaux, B., De Lentdecker, G., Favart, L., Gay, A. P. R., Hreus, T., Léonard, A., Marage, P. E., Mohammadi, A., Perniè, L., Reis, T., Seva, T., Thomas, L., Vander Velde, C., Vanlaer, P., Wang, J., Adler, V., Beernaert, K., Benucci, L., Cimmino, A., Costantini, S., Dildick, S., Garcia, G., Klein, B., Lellouch, J., Marinov, A., Mccartin, J., Ocampo Rios, A. A., Ryckbosch, D., Sigamani, M., Strobbe, N., Thyssen, F., Tytgat, M., Walsh, S., Yazgan, E., Zaganidis, N., Basegmez, S., Beluffi, C., Bruno, G., Castello, R., Caudron, A., Ceard, L., Delaere, C., du Pree, T., Favart, D., Forthomme, L., Giammanco, A., Hollar, J., Jez, P., Lemaitre, V., Liao, J., Militaru, O., Nuttens, C., Pagano, D., Pin, A., Piotrzkowski, K., Popov, A., Selvaggi, M., Vizan Garcia, J. M., Beliy, N., Caebergs, T., Daubie, E., Hammad, G. H., Alves, G. A., Correa Martins Junior, M., Martins, T., Pol, M. E., Souza, M. H. G., Aldá Júnior, W. L., Carvalho, W., Chinellato, J., Custódio, A., Da Costa, E. M., De Jesus Damiao, D., De Oliveira Martins, C., Fonseca De Souza, S., Malbouisson, H., Malek, M., Matos Figueiredo, D., Mundim, L., Nogima, H., Prado Da Silva, W. L., Santoro, A., Sznajder, A., Tonelli Manganote, E. J., Vilela Pereira, A., Bernardes, C. A., Dias, F. A., Fernandez Perez Tomei, T. R., Gregores, E. M., Lagana, C., Marinho, F., Mercadante, P. G., Novaes, S. F., Padula, Sandra S., Genchev, V., Iaydjiev, P., Piperov, S., Rodozov, M., Sultanov, G., Vutova, M., Dimitrov, A., Hadjiiska, R., Kozhuharov, V., Litov, L., Pavlov, B., Petkov, P., Bian, J. G., Chen, G. M., Chen, H. S., Jiang, C. H., Liang, D., Liang, S., Meng, X., Tao, J., Wang, J., Wang, X., Wang, Z., Xiao, H., Xu, M., Asawatangtrakuldee, C., Ban, Y., Guo, Y., Li, W., Liu, S., Mao, Y., Qian, S. J., Teng, H., Wang, D., Zhang, L., Zou, W., Avila, C., Carrillo Montoya, C. A., Gomez, J. P., Gomez Moreno, B., Sanabria, J. C., Godinovic, N., Lelas, D., Plestina, R., Polic, D., Puljak, I., Antunovic, Z., Kovac, M., Brigljevic, V., Duric, S., Kadija, K., Luetic, J., Mekterovic, D., Morovic, S., Tikvica, L., Attikis, A., Mavromanolakis, G., Mousa, J., Nicolaou, C., Ptochos, F., Razis, P. A., Finger, M., Finger, Jr., M., Assran, Y., Ellithi Kamel, A., Mahmoud, M. A., Mahrous, A., Radi, A., Kadastik, M., Müntel, M., Murumaa, M., Raidal, M., Rebane, L., Tiko, A., Eerola, P., Fedi, G., Voutilainen, M., Härkönen, J., Karimäki, V., Kinnunen, R., Kortelainen, M. J., Lampén, T., Lassila-Perini, K., Lehti, S., Lindén, T., Luukka, P., Mäenpää, T., Peltola, T., Tuominen, E., Tuominiemi, J., Tuovinen, E., Wendland, L., Korpela, A., Tuuva, T., Besancon, M., Choudhury, S., Couderc, F., Dejardin, M., Denegri, D., Fabbro, B., Faure, J. L., Ferri, F., Ganjour, S., Givernaud, A., Gras, P., Hamel de Monchenault, G., Jarry, P., Locci, E., Malcles, J., Millischer, L., Nayak, A., Rander, J., Rosowsky, A., Titov, M., Baffioni, S., Beaudette, F., Benhabib, L., Bianchini, L., Bluj, M., Busson, P., Charlot, C., Daci, N., Dahms, T., Dalchenko, M., Dobrzynski, L., Florent, A., Granier de Cassagnac, R., Haguenauer, M., Miné, P., Mironov, C., Naranjo, I. N., Nguyen, M., Ochando, C., Paganini, P., Sabes, D., Salerno, R., Sirois, Y., Veelken, C., Zabi, A., Agram, J.-L., Andrea, J., Bloch, D., Bodin, D., Brom, J.-M., Chabert, E. 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A., Sonnenschein, L., Steggemann, J., Teyssier, D., Thüer, S., Weber, M., Cherepanov, V., Erdogan, Y., Flügge, G., Geenen, H., Geisler, M., Haj Ahmad, W., Hoehle, F., Kargoll, B., Kress, T., Kuessel, Y., Lingemann, J., Nowack, A., Nugent, I. M., Perchalla, L., Pooth, O., Stahl, A., Aldaya Martin, M., Asin, I., Bartosik, N., Behr, J., Behrenhoff, W., Behrens, U., Bergholz, M., Bethani, A., Borras, K., Burgmeier, A., Cakir, A., Calligaris, L., Campbell, A., Costanza, F., Diez Pardos, C., Dooling, S., Dorland, T., Eckerlin, G., Eckstein, D., Flucke, G., Geiser, A., Glushkov, I., Gunnellini, P., Habib, S., Hauk, J., Hellwig, G., Jung, H., Kasemann, M., Katsas, P., Kleinwort, C., Kluge, H., Krämer, M., Krücker, D., Kuznetsova, E., Lange, W., Leonard, J., Lipka, K., Lohmann, W., Lutz, B., Mankel, R., Marfin, I., Melzer-Pellmann, I.-A., Meyer, A. 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R., Kornmayer, A., Lobelle Pardo, P., Martschei, D., Mueller, S., Müller, Th., Niegel, M., Nürnberg, A., Oberst, O., Ott, J., Quast, G., Rabbertz, K., Ratnikov, F., Röcker, S., Schilling, F.-P., Schott, G., Simonis, H. J., Stober, F. M., Ulrich, R., Wagner-Kuhr, J., Wayand, S., Weiler, T., Zeise, M., Anagnostou, G., Daskalakis, G., Geralis, T., Kesisoglou, S., Kyriakis, A., Loukas, D., Markou, A., Markou, C., Ntomari, E., Gouskos, L., Mertzimekis, T. J., Panagiotou, A., Saoulidou, N., Stiliaris, E., Aslanoglou, X., Evangelou, I., Flouris, G., Foudas, C., Kokkas, P., Manthos, N., Papadopoulos, I., Paradas, E., Bencze, G., Hajdu, C., Hidas, P., Horvath, D., Radics, B., Sikler, F., Veszpremi, V., Vesztergombi, G., Zsigmond, A. J., Beni, N., Czellar, S., Molnar, J., Palinkas, J., Szillasi, Z., Karancsi, J., Raics, P., Trocsanyi, Z. L., Ujvari, B., Beri, S. B., Bhatnagar, V., Dhingra, N., Gupta, R., Kaur, M., Mehta, M. Z., Mittal, M., Nishu, N., Saini, L. K., Sharma, A., Singh, J. B., Kumar, Ashok, Kumar, Arun, Ahuja, S., Bhardwaj, A., Choudhary, B. C., Malhotra, S., Naimuddin, M., Ranjan, K., Saxena, P., Sharma, V., Shivpuri, R. K., Banerjee, S., Bhattacharya, S., Chatterjee, K., Dutta, S., Gomber, B., Jain, Sa., Jain, Sh., Khurana, R., Modak, A., Mukherjee, S., Roy, D., Sarkar, S., Sharan, M., Abdulsalam, A., Dutta, D., Kailas, S., Kumar, V., Mohanty, A. K., Pant, L. M., Shukla, P., Topkar, A., Aziz, T., Chatterjee, R. M., Ganguly, S., Ghosh, S., Guchait, M., Gurtu, A., Kole, G., Kumar, S., Maity, M., Majumder, G., Mazumdar, K., Mohanty, G. B., Parida, B., Sudhakar, K., Wickramage, N., Banerjee, S., Dugad, S., Arfaei, H., Bakhshiansohi, H., Etesami, S. M., Fahim, A., Hesari, H., Jafari, A., Khakzad, M., Mohammadi Najafabadi, M., Paktinat Mehdiabadi, S., Safarzadeh, B., Zeinali, M., Grunewald, M., Abbrescia, M., Barbone, L., Calabria, C., Chhibra, S. S., Colaleo, A., Creanza, D., De Filippis, N., De Palma, M., Fiore, L., Iaselli, G., Maggi, G., Maggi, M., Marangelli, B., My, S., Nuzzo, S., Pacifico, N., Pompili, A., Pugliese, G., Selvaggi, G., Silvestris, L., Singh, G., Venditti, R., Verwilligen, P., Zito, G., Abbiendi, G., Benvenuti, A. C., Bonacorsi, D., Braibant-Giacomelli, S., Brigliadori, L., Campanini, R., Capiluppi, P., Castro, A., Cavallo, F. R., Cuffiani, M., Dallavalle, G. M., Fabbri, F., Fanfani, A., Fasanella, D., Giacomelli, P., Grandi, C., Guiducci, L., Marcellini, S., Masetti, G., Meneghelli, M., Montanari, A., Navarria, F. L., Odorici, F., Perrotta, A., Primavera, F., Rossi, A. M., Rovelli, T., Siroli, G. P., Tosi, N., Travaglini, R., Albergo, S., Chiorboli, M., Costa, S., Giordano, F., Potenza, R., Tricomi, A., Tuve, C., Barbagli, G., Ciulli, V., Civinini, C., D’Alessandro, R., Focardi, E., Frosali, S., Gallo, E., Gonzi, S., Gori, V., Lenzi, P., Meschini, M., Paoletti, S., Sguazzoni, G., Tropiano, A., Benussi, L., Bianco, S., Fabbri, F., Piccolo, D., Fabbricatore, P., Musenich, R., Tosi, S., Benaglia, A., De Guio, F., Di Matteo, L., Fiorendi, S., Gennai, S., Ghezzi, A., Govoni, P., Lucchini, M. T., Malvezzi, S., Manzoni, R. A., Martelli, A., Menasce, D., Moroni, L., Paganoni, M., Pedrini, D., Ragazzi, S., Redaelli, N., Tabarelli de Fatis, T., Buontempo, S., Cavallo, N., De Cosa, A., Fabozzi, F., Iorio, A. O. M., Lista, L., Meola, S., Merola, M., Paolucci, P., Azzi, P., Bacchetta, N., Bisello, D., Branca, A., Carlin, R., Checchia, P., Dorigo, T., Dosselli, U., Galanti, M., Gasparini, F., Gasparini, U., Giubilato, P., Gozzelino, A., Gulmini, M., Kanishchev, K., Lacaprara, S., Lazzizzera, I., Margoni, M., Maron, G., Meneguzzo, A. T., Pazzini, J., Pozzobon, N., Ronchese, P., Simonetto, F., Torassa, E., Tosi, M., Vanini, S., Zotto, P., Zucchetta, A., Zumerle, G., Gabusi, M., Ratti, S. P., Riccardi, C., Vitulo, P., Biasini, M., Bilei, G. M., Fanò, L., Lariccia, P., Mantovani, G., Menichelli, M., Nappi, A., Romeo, F., Saha, A., Santocchia, A., Spiezia, A., Androsov, K., Azzurri, P., Bagliesi, G., Boccali, T., Broccolo, G., Castaldi, R., D’Agnolo, R. T., Dell’Orso, R., Fiori, F., Foà, L., Giassi, A., Kraan, A., Ligabue, F., Lomtadze, T., Martini, L., Messineo, A., Palla, F., Rizzi, A., Serban, A. T., Spagnolo, P., Squillacioti, P., Tenchini, R., Tonelli, G., Venturi, A., Verdini, P. G., Vernieri, C., Barone, L., Cavallari, F., Del Re, D., Diemoz, M., Grassi, M., Longo, E., Margaroli, F., Meridiani, P., Micheli, F., Nourbakhsh, S., Organtini, G., Paramatti, R., Rahatlou, S., Soffi, L., Amapane, N., Arcidiacono, R., Argiro, S., Arneodo, M., Biino, C., Cartiglia, N., Casasso, S., Costa, M., Demaria, N., Mariotti, C., Maselli, S., Migliore, E., Monaco, V., Musich, M., Obertino, M. M., Ortona, G., Pastrone, N., Pelliccioni, M., Potenza, A., Romero, A., Ruspa, M., Sacchi, R., Solano, A., Staiano, A., Tamponi, U., Belforte, S., Candelise, V., Casarsa, M., Cossutti, F., Della Ricca, G., Gobbo, B., La Licata, C., Marone, M., Montanino, D., Penzo, A., Schizzi, A., Zanetti, A., Kim, T. Y., Nam, S. K., Chang, S., Kim, D. H., Kim, G. N., Kim, J. E., Kong, D. J., Oh, Y. D., Park, H., Son, D. C., Kim, J. Y., Kim, Zero J., Song, S., Choi, S., Gyun, D., Hong, B., Jo, M., Kim, H., Kim, T. J., Lee, K. S., Park, S. K., Roh, Y., Choi, M., Kim, J. H., Park, C., Park, I. 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G., Gallinaro, M., Rodrigues Antunes, J., Seixas, J., Varela, J., Vischia, P., Bunin, P., Gavrilenko, M., Golutvin, I., Gorbunov, I., Kamenev, A., Karjavin, V., Konoplyanikov, V., Kozlov, G., Lanev, A., Malakhov, A., Matveev, V., Moisenz, P., Palichik, V., Perelygin, V., Shmatov, S., Skatchkov, N., Smirnov, V., Zarubin, A., Evstyukhin, S., Golovtsov, V., Ivanov, Y., Kim, V., Levchenko, P., Murzin, V., Oreshkin, V., Smirnov, I., Sulimov, V., Uvarov, L., Vavilov, S., Vorobyev, A., Vorobyev, An., Andreev, Yu., Dermenev, A., Gninenko, S., Golubev, N., Kirsanov, M., Krasnikov, N., Pashenkov, A., Tlisov, D., Toropin, A., Epshteyn, V., Erofeeva, M., Gavrilov, V., Lychkovskaya, N., Popov, V., Safronov, G., Semenov, S., Spiridonov, A., Stolin, V., Vlasov, E., Zhokin, A., Andreev, V., Azarkin, M., Dremin, I., Kirakosyan, M., Leonidov, A., Mesyats, G., Rusakov, S. V., Vinogradov, A., Belyaev, A., Boos, E., Bunichev, V., Dubinin, M., Dudko, L., Ershov, A., Gribushin, A., Klyukhin, V., Kodolova, O., Lokhtin, I., Markina, A., Obraztsov, S., Savrin, V., Snigirev, A., Azhgirey, I., Bayshev, I., Bitioukov, S., Kachanov, V., Kalinin, A., Konstantinov, D., Krychkine, V., Petrov, V., Ryutin, R., Sobol, A., Tourtchanovitch, L., Troshin, S., Tyurin, N., Uzunian, A., Volkov, A., Adzic, P., Ekmedzic, M., Krpic, D., Milosevic, J., Aguilar-Benitez, M., Alcaraz Maestre, J., Battilana, C., Calvo, E., Cerrada, M., Chamizo Llatas, M., Colino, N., De La Cruz, B., Delgado Peris, A., Domínguez Vázquez, D., Fernandez Bedoya, C., Fernández Ramos, J. P., Ferrando, A., Flix, J., Fouz, M. C., Garcia-Abia, P., Gonzalez Lopez, O., Goy Lopez, S., Hernandez, J. M., Josa, M. I., Merino, G., Navarro De Martino, E., Puerta Pelayo, J., Quintario Olmeda, A., Redondo, I., Romero, L., Santaolalla, J., Soares, M. S., Willmott, C., Albajar, C., de Trocóniz, J. 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A., Colafranceschi, S., d’Enterria, D., Dabrowski, A., De Roeck, A., De Visscher, S., Di Guida, S., Dobson, M., Dupont-Sagorin, N., Elliott-Peisert, A., Eugster, J., Funk, W., Georgiou, G., Giffels, M., Gigi, D., Gill, K., Giordano, D., Girone, M., Giunta, M., Glege, F., Gomez-Reino Garrido, R., Gowdy, S., Guida, R., Hammer, J., Hansen, M., Harris, P., Hartl, C., Hinzmann, A., Innocente, V., Janot, P., Karavakis, E., Kousouris, K., Krajczar, K., Lecoq, P., Lee, Y.-J., Lourenço, C., Magini, N., Malberti, M., Malgeri, L., Mannelli, M., Masetti, L., Meijers, F., Mersi, S., Meschi, E., Moser, R., Mulders, M., Musella, P., Nesvold, E., Orsini, L., Palencia Cortezon, E., Perez, E., Perrozzi, L., Petrilli, A., Pfeiffer, A., Pierini, M., Pimiä, M., Piparo, D., Plagge, M., Polese, G., Quertenmont, L., Racz, A., Reece, W., Rolandi, G., Rovelli, C., Rovere, M., Sakulin, H., Santanastasio, F., Schäfer, C., Schwick, C., Segoni, I., Sekmen, S., Sharma, A., Siegrist, P., Silva, P., Simon, M., Sphicas, P., Spiga, D., Stoye, M., Tsirou, A., Veres, G. I., Vlimant, J. R., Wöhri, H. K., Worm, S. D., Zeuner, W. D., Bertl, W., Deiters, K., Erdmann, W., Gabathuler, K., Horisberger, R., Ingram, Q., Kaestli, H. C., König, S., Kotlinski, D., Langenegger, U., Renker, D., Rohe, T., Bachmair, F., Bäni, L., Bortignon, P., Buchmann, M. A., Casal, B., Chanon, N., Deisher, A., Dissertori, G., Dittmar, M., Donegà, M., Dünser, M., Eller, P., Freudenreich, K., Grab, C., Hits, D., Lecomte, P., Lustermann, W., Marini, A. C., Martinez Ruiz del Arbol, P., Mohr, N., Moortgat, F., Nägeli, C., Nef, P., Nessi-Tedaldi, F., Pandolfi, F., Pape, L., Pauss, F., Peruzzi, M., Ronga, F. J., Rossini, M., Sala, L., Sanchez, A. K., Starodumov, A., Stieger, B., Takahashi, M., Tauscher, L., Thea, A., Theofilatos, K., Treille, D., Urscheler, C., Wallny, R., Weber, H. A., Amsler, C., Chiochia, V., Favaro, C., Ivova Rikova, M., Kilminster, B., Millan Mejias, B., Otiougova, P., Robmann, P., Snoek, H., Taroni, S., Tupputi, S., Verzetti, M., Cardaci, M., Chen, K. 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M., Rogerson, S., Rose, A., Seez, C., Sharp, P., Sparrow, A., Tapper, A., Vazquez Acosta, M., Virdee, T., Wakefield, S., Wardle, N., Whyntie, T., Chadwick, M., Cole, J. E., Hobson, P. R., Khan, A., Kyberd, P., Leggat, D., Leslie, D., Martin, W., Reid, I. D., Symonds, P., Teodorescu, L., Turner, M., Dittmann, J., Hatakeyama, K., Kasmi, A., Liu, H., Scarborough, T., Charaf, O., Cooper, S. I., Henderson, C., Rumerio, P., Avetisyan, A., Bose, T., Fantasia, C., Heister, A., Lawson, P., Lazic, D., Rohlf, J., Sperka, D., St. John, J., Sulak, L., Alimena, J., Bhattacharya, S., Christopher, G., Cutts, D., Demiragli, Z., Ferapontov, A., Garabedian, A., Heintz, U., Kukartsev, G., Laird, E., Landsberg, G., Luk, M., Narain, M., Segala, M., Sinthuprasith, T., Speer, T., Breedon, R., Breto, G., Calderon De La Barca Sanchez, M., Chauhan, S., Chertok, M., Conway, J., Conway, R., Cox, P. 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M., Kroeger, R., Perera, L., Rahmat, R., Sanders, D. A., Summers, D., Avdeeva, E., Bloom, K., Bose, S., Claes, D. R., Dominguez, A., Eads, M., Gonzalez Suarez, R., Keller, J., Kravchenko, I., Lazo-Flores, J., Malik, S., Meier, F., Snow, G. R., Dolen, J., Godshalk, A., Iashvili, I., Jain, S., Kharchilava, A., Kumar, A., Rappoccio, S., Wan, Z., Alverson, G., Barberis, E., Baumgartel, D., Chasco, M., Haley, J., Massironi, A., Nash, D., Orimoto, T., Trocino, D., Wood, D., Zhang, J., Anastassov, A., Hahn, K. A., Kubik, A., Lusito, L., Mucia, N., Odell, N., Pollack, B., Pozdnyakov, A., Schmitt, M., Stoynev, S., Velasco, M., Won, S., Berry, D., Brinkerhoff, A., Chan, K. M., Hildreth, M., Jessop, C., Karmgard, D. J., Kolb, J., Lannon, K., Luo, W., Lynch, S., Marinelli, N., Morse, D. M., Pearson, T., Planer, M., Ruchti, R., Slaunwhite, J., Valls, N., Wayne, M., Wolf, M., Antonelli, L., Bylsma, B., Durkin, L. S., Hill, C., Hughes, R., Kotov, K., Ling, T. Y., Puigh, D., Rodenburg, M., Smith, G., Vuosalo, C., Williams, G., Winer, B. L., Wolfe, H., Berry, E., Elmer, P., Halyo, V., Hebda, P., Hegeman, J., Hunt, A., Jindal, P., Koay, S. A., Lopes Pegna, D., Lujan, P., Marlow, D., Medvedeva, T., Mooney, M., Olsen, J., Piroué, P., Quan, X., Raval, A., Saka, H., Stickland, D., Tully, C., Werner, J. S., Zenz, S. C., Zuranski, A., Brownson, E., Lopez, A., Mendez, H., Ramirez Vargas, J. E., Alagoz, E., Benedetti, D., Bolla, G., Bortoletto, D., De Mattia, M., Everett, A., Hu, Z., Jones, M., Jung, K., Koybasi, O., Kress, M., Leonardo, N., Maroussov, V., Merkel, P., Miller, D. H., Neumeister, N., Shipsey, I., Silvers, D., Svyatkovskiy, A., Vidal Marono, M., Wang, F., Xu, L., Yoo, H. D., Zablocki, J., Zheng, Y., Guragain, S., Parashar, N., Adair, A., Akgun, B., Ecklund, K. M., Geurts, F. J. M., Li, W., Padley, B. P., Redjimi, R., Roberts, J., Zabel, J., Betchart, B., Bodek, A., Covarelli, R., de Barbaro, P., Demina, R., Eshaq, Y., Ferbel, T., Garcia-Bellido, A., Goldenzweig, P., Han, J., Harel, A., Miner, D. C., Petrillo, G., Vishnevskiy, D., Zielinski, M., Bhatti, A., Ciesielski, R., Demortier, L., Goulianos, K., Lungu, G., Malik, S., Mesropian, C., Arora, S., Barker, A., Chou, J. P., Contreras-Campana, C., Contreras-Campana, E., Duggan, D., Ferencek, D., Gershtein, Y., Gray, R., Halkiadakis, E., Hidas, D., Lath, A., Panwalkar, S., Park, M., Patel, R., Rekovic, V., Robles, J., Rose, K., Salur, S., Schnetzer, S., Seitz, C., Somalwar, S., Stone, R., Thomas, S., Walker, M., Cerizza, G., Hollingsworth, M., Spanier, S., Yang, Z. C., York, A., Eusebi, R., Flanagan, W., Gilmore, J., Kamon, T., Khotilovich, V., Montalvo, R., Osipenkov, I., Pakhotin, Y., Perloff, A., Roe, J., Safonov, A., Sakuma, T., Suarez, I., Tatarinov, A., Toback, D., Akchurin, N., Damgov, J., Dragoiu, C., Dudero, P. R., Jeong, C., Kovitanggoon, K., Lee, S. W., Libeiro, T., Volobouev, I., Appelt, E., Delannoy, A. G., Greene, S., Gurrola, A., Johns, W., Maguire, C., Mao, Y., Melo, A., Sharma, M., Sheldon, P., Snook, B., Tuo, S., Velkovska, J., Arenton, M. W., Boutle, S., Cox, B., Francis, B., Goodell, J., Hirosky, R., Ledovskoy, A., Lin, C., Neu, C., Wood, J., Gollapinni, S., Harr, R., Karchin, P. E., Kottachchi Kankanamge Don, C., Lamichhane, P., Sakharov, A., Anderson, M., Belknap, D. A., Borrello, L., Carlsmith, D., Cepeda, M., Dasu, S., Friis, E., Grogg, K. S., Grothe, M., Hall-Wilton, R., Herndon, M., Hervé, A., Kaadze, K., Klabbers, P., Klukas, J., Lanaro, A., Lazaridis, C., Loveless, R., Mohapatra, A., Mozer, M. U., Ojalvo, I., Pierro, G. A., Ross, I., Savin, A., Smith, W. H., and Swanson, J.

Published
2022
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36. The Therapeutic Effect and the Possible Mechanism of C-Phycocyanin in Lipopolysaccharide and Seawater-Induced Acute Lung Injury

Author

Zhang L, Kong D, Huang J, Wang Q, and Shao L

Subjects
c-phycocyanin, acute lung injury, inflammation, nf-κb/nlrp3, apoptosis, Therapeutics. Pharmacology, RM1-950
Abstract

Leifang Zhang,1 Deyi Kong,1 Junxia Huang,1 Qiongfen Wang,2 Lilin Shao1 1Zhejiang Provincial Engineering Technology Research Center of Marine Biomedical Products, School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan, 316022, People’s Republic of China; 2Zhoushan Institute of Calibration and Testing for Quality and Technical Supervision, Zhoushan, 316012, Zhejiang, People’s Republic of ChinaCorrespondence: Leifang Zhang, Zhejiang Provincial Engineering Technology Research Center of Marine Biomedical Products, School of Food and Pharmacy, Zhejiang Ocean University, 1 Haida South Road, Changzhi Island, Zhoushan, 316022, Zhejiang, People’s Republic of China, Tel +86 18 8570 63534, Fax +86 58 0 254 781, Email zhanglf@zjou.edu.cnBackground: Seawater drowning-induced acute lung injury (ALI) is a severe clinical condition characterized by increased alveolar-capillary permeability, excessive inflammatory response, and refractory hypoxemia. C-phycocyanin (C-PC), a biliprotein found in blue-green algae such as spirulina platensis, is widely used in the food and dietary nutritional supplement fields due to its beneficial pharmacological effects. Previous studies have revealed that C-PC has anti-inflammatory, antioxidant, and anti-apoptotic activities.Purpose: Therefore, this study investigated the protective effect and underlying mechanisms of C-PC on lipopolysaccharide (LPS) and seawater (SW) induced ALI (SW and LPS-induced ALI).Methods: An SW and LPS mouse model of ALI mice was established through intratracheal administration of 5mg/kg LPS and 25% SW. Different doses of C-PC (100, 200 and 400 mg/kg) were administered by intraperitoneal injection for seven days. In addition, gap junction communication in RAW264.7 and MLE-12 cells was determined following stimulation with 25% SW and 10 μg/ml LPS after treatment with C-PC (120 μg/ml). Moreover, the arterial partial pressure of oxygen, lung wet/dry weight ratios, total protein content and MPO levels in the bronchoalveolar lavage fluid (BALF), and the histopathologic and ultrastructure staining of the lung tissues were determined. The oxidative stress index, levels of the pro-inflammatory mediators, epithelial cell viability and apoptosis, and the regulatory effect of C-PC on the NF-κB/NLRP3 axis were investigated.Results: The results showed that C-PC significantly alleviated pathological damages, suppressed oxidative stress, inflammation and apoptosis, and enhanced the viability of epithelial cells in the lung tissues. Furthermore, C-PC was shown to inhibit activation of the NF-κB/NLRP3 pathway and the formation of the NLRP3 inflammasome complex.Conclusions: In conclusion, C-PC shows promising therapeutic value in SW and LPS-induced ALI/ARDS, providing new insight into ALI/ARDS treatment.Keywords: C-phycocyanin, acute lung injury, inflammation, NF-κB/NLRP3, apoptosis

Published
2022

37. Multifunctional Targeting Liposomes of Epirubicin Plus Resveratrol Improved Therapeutic Effect on Brain Gliomas

Author

Kong D, Hong W, Yu M, Li Y, Zheng YX, and Ying X

Subjects
multifunctional targeting liposomes, blood-brain barrier, apoptosis, resveratrol, brain gliomas, Medicine (General), R5-920
Abstract

Dehua Kong,&ast; Wenyu Hong,&ast; Miao Yu, Yanxia Li, YaXin Zheng, Xue Ying Collaborative Innovation Center of Sichuan for Elderly Care and Health & Key Laboratory of Sichuan Province for Specific Structure of Small Molecule Drugs, School of Pharmaceutical Sciences, Chengdu Medical College, Chengdu, 610500, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Xue Ying; YaXin Zheng, School of Pharmaceutical Sciences, Chengdu Medical College, Chengdu, 610500, People’s Republic of China, Tel +86 135-7945-5890 ; +86 173-8187-6167, Email yingxueshzu@163.com; zhengyaxinxyz@163.comIntroduction: The inability of many therapeutic molecules to cross the blood–brain barrier (BBB) combined with poor penetration into tumor tissue leads to difficult challenges for treatment of brain tumors. In order to settle these hurdles, we developed a novel multifunctional targeting carrier which enables drugs to transport across the BBB and targets brain tumor tissues.Methods: In the multifunctional targeting liposomes, the natural compound resveratrol (RES) was incorporated into the lipid bilayer membranes of liposomes, while p-aminophenyl-α-D-manno-pyranoside (MAN) and wheat germ agglutinin (WGA) were conjugated to the liposomal surface. Epirubicin (EPI) as an anticancer drug was then loaded into liposomes. Then, liposomes were characterized by evaluation on particle size, zeta potential and apparent morphology. The epirubicin plus resveratrol liposomes modified with WGA and MAN were applied to glioma cells and BBB model in vitro and C6 glioma-bearing rats in vivo.Results: The multifunctional targeting liposomes were round shaped with a smooth surface and uniform particle size. In consideration of the SRB results, the multifunctional targeting liposomes indicated a significant inhibitory effect, suggesting that MAN plus WGA generated robust drug delivery effects into the brain tumor cells. The glioma cells after administering epirubicin plus resveratrol liposomes modified with WGA and MAN displayed the most significant uptake and apoptosis conducted by flow cytometry. In the multifunctional targeting effects assay, the epirubicin plus resveratrol liposomes modified with WGA and MAN exhibited the strongest effects of crossing the BBB and then targeting brain tumor cells. In tumor-bearing rats after applying multifunctional targeting liposomes, the median survival time was evidently observed as being markedly longer than other controls.Conclusion: The epirubicin plus resveratrol liposomes modified with WGA and MAN exhibited strong ability to improve epirubicin and resveratrol transporting across the BBB and therapeutic effect on brain glioma, showing multifunctional targeting capability.Graphical Abstract: Keywords: multifunctional targeting liposomes, blood–brain barrier, apoptosis, resveratrol, brain gliomas

Published
2022

38. Construction and Response of a Highly Granular Scintillator-based Electromagnetic Calorimeter

Author

CALICE collaboration, Repond, J., Xia, L., Eigen, G., Price, T., Watson, N. K., Winter, A., Thomson, M. A., Blazey, G. C., Dyshkant, A., Francis, K., Zutshi, V., Gadow, K., Göttlicher, P., Hartbrich, O., Krivan, F., Krüger, K., Lu, S., Lutz, B., Reinecke, M., Sefkow, F., Sudo, Y., Tran, H. L., Kaplan, A., Schultz-Coulon, H. -Ch., Bilki, B., Northacker, D., Onel, Y., Wilson, G. W., Kawagoe, K., Sekiya, I., Suehara, T., Yamashiro, H., Yoshioka, T., Gabriel, M., Goecke, P., Graf, C., Israeli, Y., van der Kolk, N., Simon, F., Szalay, M., Winde, H., Bilokin, l S., Bonis, J., Pöschl, R., Thiebault, A., Richard, F., Zerwas, D., Anduze, M., Balagura, V., Boudry, V., Brient, J-C., Cornat, R., Cvach, J., Janata, M., Kovalcuk, M., Kvasnicka, J., Polak, I., Smolik, J., Vrba, V., Zalesak, J., Zuklin, J., Choi, W., Kotera, K., Nishiyama, M., Sakuma, T., Takeshita, T., Tozuka, S., Tsubokawa, T., Uozumi, S., Jeans, D., Ootani, W., Liu, L., Chang, S., Khan, A., Kim, D. H., Kong, D. J., Oh, Y. D., Ikuno, T., Takahashi, Y., and Götze, M.

Subjects
Physics - Instrumentation and Detectors
Abstract

A highly granular electromagnetic calorimeter with scintillator strip readout is being developed for future lepton collider experiments. A prototype of 21.5 $X_0$ depth and $180 \times 180 $mm$^2$ transverse dimensions was constructed, consisting of 2160 individually read out $10 \times 45 \times 3$ mm$^3$ scintillator strips. This prototype was tested using electrons of 2--32 GeV at the Fermilab Test Beam Facility in 2009. Deviations from linear energy response were less than 1.1\%, and the intrinsic energy resolution was determined to be $(12.5 \pm 0.1 (\mathrm{stat.}) \pm0.4 (\mathrm{syst.}))\%/\sqrt{E[\mathrm{GeV}]}\oplus (1.2 \pm 0.1(\mathrm{stat.})^{+0.6}_{-0.7}(\mathrm{syst.}))\%$, where the uncertainties correspond to statistical and systematic sources, respectively., Comment: This article is published in Nuclear Inst. and Methods in Physics Research, A 887 (2018) 150-168

Published
2017

39. The eruption of a small-scale emerging flux rope as the driver of an M-class flare and a coronal mass ejection

Author

Yan, X. L., Jiang, C. W., Xue, Z. K., Wang, J. C., Priest, E. R., Yang, L. H., Kong, D. F., Cao, W. D., and Ji, H. S.

Subjects
Astrophysics - Solar and Stellar Astrophysics
Abstract

Solar flares and coronal mass ejections (CMEs) are the most powerful explosions in the Sun. They are major sources of potentially destructive space weather conditions. However, the possible causes of their initiation remain controversial. By using high resolution data observed by NST of BBSO, supplemented by Solar Dynamics Observatory (SDO) observations, we present unusual observations of a small-scale emerging flux rope near a large sunspot, whose eruption produced an M-class flare and a coronal mass ejection. The presence of the small-scale flux rope was indicated by static nonlinear force free field (NLFFF) extrapolation as well as data-driven MHD modeling of the dynamic evolution of the coronal 3D magnetic field. During the emergence of the flux rope, rotation of satellite sunspots at the footpoints of the flux rope was observed. Meanwhile, the Lorentz force, magnetic energy, vertical current, and transverse fields were increasing during this phase. The free energy from the magnetic flux emergence and twisting magnetic fields is sufficient to power the M-class flare. These observations for the first time present the complete process from the emergence of the small-scale flux rope to the production of solar eruptions., Comment: 26 pages,7 figures, accepted for publication in ApJ

Published
2017
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40. Measurement of the inclusive-isolated prompt-photon cross section in $p\bar{p}$ collisions using the full CDF data set

Author

CDF Collaboration, Aaltonen, T., Albrow, M. G., Amerio, S., Amidei, D., Anastassov, A., Annovi, A., Antos, J., Apollinari, G., Appel, J. A., Arisawa, T., Artikov, A., Asaadi, J., Ashmanskas, W., Auerbach, B., Aurisano, A., Azfar, F., Badgett, W., Bae, T., Barbaro-Galtieri, A., Barnes, V. E., Barnett, B. A., Barria, P., Bartos, P., Bauce, M., Bedeschi, F., Behari, S., Bellettini, G., Bellinger, J., Benjamin, D., Beretvas, A., Bhatti, A., Bland, K. R., Blumenfeld, B., Bocci, A., Bodek, A., Bortoletto, D., Boudreau, J., Boveia, A., Brigliadori, L., Bromberg, C., Brucken, E., Budagov, J., Budd, H. S., Burkett, K., Busetto, G., Bussey, P., Butti, P., Buzatu, A., Calamba, A., Camarda, S., Campanelli, M., Canelli, F., Carls, B., Carlsmith, D., Carosi, R., Carrillo, S., Casal, B., Casarsa, M., Castro, A., Catastini, P., Cauz, D., Cavaliere, V., Cerri, A., Cerrito, L., Chen, Y. C., Chertok, M., Chiarelli, G., Chlachidze, G., Cho, K., Chokheli, D., Clark, A., Clarke, C., Convery, M. E., Conway, J., Corbo, M., Cordelli, M., Cox, C. A., Cox, D. J., Cremonesi, M., Cruz, D., Cuevas, J., Culbertson, R., d'Ascenzo, N., Datta, M., de Barbaro, P., Demortier, L., Deninno, M., Devoto, F., D'Errico, M., Di Canto, A., Di Ruzza, B., Dittmann, J. R., D'Onofrio, M., Donati, S., Dorigo, M., Driutti, A., Ebina, K., Edgar, R., Erbacher, R., Errede, S., Esham, B., Farrington, S., Ramos, J. P. Fernández, Field, R., Flanagan, G., Forrest, R., Franklin, M., Freeman, J. C., Frisch, H., Funakoshi, Y., Galloni, C., Garfinkel, A. F., Garosi, P., Gerberich, H., Gerchtein, E., Giagu, S., Giakoumopoulou, V., Gibson, K., Ginsburg, C. M., Giokaris, N., Giromini, P., Glagolev, V., Glenzinski, D., Gold, M., Goldin, D., Golossanov, A., Gomez, G., Gomez-Ceballos, G., Goncharov, M., López, O. González, Gorelov, I., Goshaw, A. T., Goulianos, K., Gramellini, E., Grosso-Pilcher, C., da Costa, J. Guimaraes, Hahn, S. R., Han, J. Y., Happacher, F., Hara, K., Hare, M., Harr, R. F., Harrington-Taber, T., Hatakeyama, K., Hays, C., Heinrich, J., Herndon, M., Hocker, A., Hong, Z., Hopkins, W., Hou, S., Hughes, R. E., Husemann, U., Hussein, M., Huston, J., Introzzi, G., Iori, M., Ivanov, A., James, E., Jang, D., Jayatilaka, B., Jeon, E. J., Jindariani, S., Jones, M., Joo, K. K., Jun, S. Y., Junk, T. R., Kambeitz, M., Kamon, T., Karchin, P. E., Kasmi, A., Kato, Y., Ketchum, W., Keung, J., Kilminster, B., Kim, D. H., Kim, H. S., Kim, J. E., Kim, M. J., Kim, S. B., Kim, S. H., Kim, Y. K., Kim, Y. J., Kimura, N., Kirby, M., Kondo, K., Kong, D. J., Konigsberg, J., Kotwal, A. V., Kreps, M., Kroll, J., Kruse, M., Kuhr, T., Kurata, M., Laasanen, A. T., Lammel, S., Lancaster, M., Lannon, K., Latino, G., Lee, H. S., Lee, J. S., Leo, S., Leone, S., Lewis, J. D., Limosani, A., Lipeles, E., Lister, A., Liu, Q., Liu, T., Lockwitz, S., Loginov, A., Lucà, A., Lucchesi, D., Lueck, J., Lujan, P., Lukens, P., Lungu, G., Lys, J., Lysak, R., Madrak, R., Maestro, P., Malik, S., Manca, G., Manousakis-Katsikakis, A., Marchese, L., Margaroli, F., Marino, P., Matera, K., Mattson, M. E., Mazzacane, A., Mazzanti, P., McNulty, R., Mehta, A., Mehtala, P., Mesropian, C., Miao, T., Mietlicki, D., Mitra, A., Miyake, H., Moed, S., Moggi, N., Moon, C. S., Moore, R., Morello, M. J., Mukherjee, A., Muller, Th., Murat, P., Mussini, M., Nachtman, J., Nagai, Y., Naganoma, J., Nakano, I., Napier, A., Nett, J., Nigmanov, T., Nodulman, L., Noh, S. Y., Norniella, O., Oakes, L., Oh, S. H., Oh, Y. D., Okusawa, T., Orava, R., Ortolan, L., Pagliarone, C., Palencia, E., Palni, P., Papadimitriou, V., Parker, W., Pauletta, G., Paulini, M., Paus, C., Phillips, T. J., Piacentino, G., Pianori, E., Pilot, J., Pitts, K., Plager, C., Pondrom, L., Poprocki, S., Potamianos, K., Prokoshin, F., Pranko, A., Ptohos, F., Punzi, G., Fernández, I. Redondo, Renton, P., Rescigno, M., Rimondi, F., Ristori, L., Robson, A., Rodriguez, T., Rolli, S., Ronzani, M., Roser, R., Rosner, J. L., Ruffini, F., Ruiz, A., Russ, J., Rusu, V., Sakumoto, W. K., Sakurai, Y., Santi, L., Sato, K., Saveliev, V., Savoy-Navarro, A., Schlabach, P., Schmidt, E. E., Schwarz, T., Scodellaro, L., Scuri, F., Seidel, S., Seiya, Y., Semenov, A., Sforza, F., Shalhout, S. Z., Shears, T., Shepard, P. F., Shimojima, M., Shochet, M., Shreyber-Tecker, I., Simonenko, A., Sinervo, P., Sliwa, K., Smith, J. R., Snider, F. D., Sorin, V., Song, H., Stancari, M., Denis, R. St., Stentz, D., Strologas, J., Sudo, Y., Sukhanov, A., Suslov, I., Takemasa, K., Takeuchi, Y., Tang, J., Tecchio, M., Teng, P. K., Thom, J., Thomson, E., Thukral, V., Toback, D., Tokar, S., Tollefson, K., Tomura, T., Tonelli, D., Torre, S., Torretta, D., Totaro, P., Trovato, M., Ukegawa, F., Uozumi, S., Vázquez, F., Velev, G., Vellidis, C., Vernieri, C., Vidal, M., Vilar, R., Vizán, J., Vogel, M., Volpi, G., Wagner, P., Wallny, R., Wang, S. M., Waters, D., Wester III, W. C., Whiteson, D., Wicklund, A. B., Wilbur, S., Williams, H. H., Wilson, J. S., Wilson, P., Winer, B. L., Wittich, P., Wolbers, S., Wolfe, H., Wright, T., Wu, X., Wu, Z., Yamamoto, K., Yamato, D., Yang, T., Yang, U. K., Yang, Y. C., Yao, W. -M., Yeh, G. P., Yi, K., Yoh, J., Yorita, K., Yoshida, T., Yu, G. B., Yu, I., Zanetti, A. M., Zeng, Y., Zhou, C., and Zucchelli, S.

Subjects
High Energy Physics - Experiment
Abstract

A measurement of the inclusive production cross section of isolated prompt photons in proton-antiproton collisions at center-of-mass energy $\sqrt{s}$=1.96TeV is presented. The results are obtained using the full Run II data sample collected with the Collider Detector at the Fermilab Tevatron, which corresponds to an integrated luminosity of 9.5fb$^{-1}$. The cross section is measured as a function of photon transverse energy, $E_T^{\gamma}$, in the range 30$ < E_T^{\gamma} <$500GeV and in the pseudorapidity region $|\eta^{\gamma}|<$1.0. The results are compared with predictions from parton-shower Monte Carlo models at leading order in quantum chromodynamics (QCD) and from next-to-leading order perturbative QCD calculations. The latter show good agreement with the measured cross section., Comment: submitted to Phys. Rev. D - RC

Published
2017
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41. The triple point path prediction model based on geometric method.

Author

Xi, H. Z., Kong, D. R., Peng, Y. Q., Shi, Q., Zhang, S. M., and Le, G. G.

Subjects
*LEAST squares, *PREDICTION models, *SHOCK waves, *COMPUTER simulation, *LEGAL education
Abstract

The pressure-time relation in the shock flow field of a near-earth air blast is complex. The triple point (TP) path is the physical boundary between the free and non-free shock flow fields. Accurately predicting the TP path is the basis for studying the evolution law of the reflection flow field and the guarantee of effectively assessing the damage power of the warhead. Based on the assumption that the Mach stem center is on the projection point of the blast center on the ground, the TP path calculation method was constructed by the geometric relationship. The unknown coefficients were solved using the existing TP data and the least square method. The TP prediction model proposed was compared with the existing ones on the calibration, new numerical simulation TP, and the measured real blast datasets. The error of the new numerical simulation TP data is within ±15% of the real value. The results show that the TP path prediction model proposed performs better. Most of its prediction results are within ±20% of three datasets compared to other models for the working conditions with the scaled height of burst from 0.397 to 2.777 m/kg1/3 and the horizontal scaled distance within 10 m/kg1/3 in the conventional cylindrical TNT explosion with the length-diameter of 1 in the air. The reliability of the prediction model is verified. [ABSTRACT FROM AUTHOR]

Published
2024
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42. Experimental Study and Numerical Simulation for the Anti-explosion Performance of Steel Plate-Reinforced Concrete Composite Beam

Author

Wang, X. F., Li, L., Zhang, L., Liu, J. B., Kong, D. F., Sun, G. J., di Prisco, Marco, Series Editor, Chen, Sheng-Hong, Series Editor, Vayas, Ioannis, Series Editor, Kumar Shukla, Sanjay, Series Editor, Sharma, Anuj, Series Editor, Kumar, Nagesh, Series Editor, Wang, Chien Ming, Series Editor, Dao, Vinh, editor, and Kitipornchai, Sritawat, editor

Published
2021
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43. Stone size guidance of robotic RIRS

Author

Song, K-S., primary, Hong, S.H., additional, Jang, J.H., additional, Kim, J., additional, Park, H., additional, Lee, D., additional, Kong, D., additional, Kwon, D.S., additional, and Cho, S.Y., additional

Published
2024
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44. Measurement of the $D^+$-meson production cross section at low transverse momentum in $p\bar{p}$ collisions at $\sqrt{s}=1.96$ TeV

Author

CDF Collaboration, Aaltonen, T., Amerio, S., Amidei, D., Anastassov, A., Annovi, A., Antos, J., Apollinari, G., Appel, J. A., Arisawa, T., Artikov, A., Asaadi, J., Ashmanskas, W., Auerbach, B., Aurisano, A., Azfar, F., Badgett, W., Bae, T., Barbaro-Galtieri, A., Barnes, V. E., Barnett, B. A., Barria, P., Bartos, P., Bauce, M., Bedeschi, F., Behari, S., Bellettini, G., Bellinger, J., Benjamin, D., Beretvas, A., Bhatti, A., Bland, K. R., Blumenfeld, B., Bocci, A., Bodek, A., Bortoletto, D., Boudreau, J., Boveia, A., Brigliadori, L., Bromberg, C., Brucken, E., Budagov, J., Budd, H. S., Burkett, K., Busetto, G., Bussey, P., Butti, P., Buzatu, A., Calamba, A., Camarda, S., Campanelli, M., Canelli, F., Carls, B., Carlsmith, D., Carosi, R., Carrillo, S., Casal, B., Casarsa, M., Castro, A., Catastini, P., Cauz, D., Cavaliere, V., Cerri, A., Cerrito, L., Chen, Y. C., Chertok, M., Chiarelli, G., Chlachidze, G., Cho, K., Chokheli, D., Clark, A., Clarke, C., Convery, M. E., Conway, J., Corbo, M., Cordelli, M., Cox, C. A., Cox, D. J., Cremonesi, M., Cruz, D., Cuevas, J., Culbertson, R., d'Ascenzo, N., Datta, M., de Barbaro, P., Demortier, L., Deninno, M., Devoto, F., D'Errico, M., Di Canto, A., Di Ruzza, B., Dittmann, J. R., D'Onofrio, M., Donati, S., Dorigo, M., Driutti, A., Ebina, K., Edgar, R., Erbacher, R., Errede, S., Esham, B., Farrington, S., Ramos, J. P. Fernández, Field, R., Flanagan, G., Forrest, R., Franklin, M., Freeman, J. C., Frisch, H., Funakoshi, Y., Galloni, C., Garfinkel, A. F., Garosi, P., Gerberich, H., Gerchtein, E., Giagu, S., Giakoumopoulou, V., Gibson, K., Ginsburg, C. M., Giokaris, N., Giromini, P., Glagolev, V., Glenzinski, D., Gold, M., Goldin, D., Golossanov, A., Gomez, G., Gomez-Ceballos, G., Goncharov, M., López, O. González, Gorelov, I., Goshaw, A. T., Goulianos, K., Gramellini, E., Grosso-Pilcher, C., da Costa, J. Guimaraes, Hahn, S. R., Han, J. Y., Happacher, F., Hara, K., Hare, M., Harr, R. F., Harrington-Taber, T., Hatakeyama, K., Hays, C., Heinrich, J., Herndon, M., Hocker, A., Hong, Z., Hopkins, W., Hou, S., Hughes, R. E., Husemann, U., Hussein, M., Huston, J., Introzzi, G., Iori, M., Ivanov, A., James, E., Jang, D., Jayatilaka, B., Jeon, E. J., Jindariani, S., Jones, M., Joo, K. K., Jun, S. Y., Junk, T. R., Kambeitz, M., Kamon, T., Karchin, P. E., Kasmi, A., Kato, Y., Ketchum, W., Keung, J., Kilminster, B., Kim, D. H., Kim, H. S., Kim, J. E., Kim, M. J., Kim, S. B., Kim, S. H., Kim, Y. K., Kim, Y. J., Kimura, N., Kirby, M., Kondo, K., Kong, D. J., Konigsberg, J., Kotwal, A. V., Kreps, M., Kroll, J., Kruse, M., Kuhr, T., Kurata, M., Laasanen, A. T., Lammel, S., Lancaster, M., Lannon, K., Latino, G., Lee, H. S., Lee, J. S., Leo, S., Leone, S., Lewis, J. D., Limosani, A., Lipeles, E., Lister, A., Liu, Q., Liu, T., Lockwitz, S., Loginov, A., Lucà, A., Lucchesi, D., Lueck, J., Lujan, P., Lukens, P., Lungu, G., Lys, J., Lysak, R., Madrak, R., Maestro, P., Malik, S., Manca, G., Manousakis-Katsikakis, A., Marchese, L., Margaroli, F., Marino, P., Matera, K., Mattson, M. E., Mazzacane, A., Mazzanti, P., McNulty, R., Mehta, A., Mehtala, P., Mesropian, C., Miao, T., Mietlicki, D., Mitra, A., Miyake, H., Moed, S., Moggi, N., Moon, C. S., Moore, R., Morello, M. J., Mukherjee, A., Muller, Th., Murat, P., Mussini, M., Nachtman, J., Nagai, Y., Naganoma, J., Nakano, I., Napier, A., Nett, J., Nigmanov, T., Nodulman, L., Noh, S. Y., Norniella, O., Oakes, L., Oh, S. H., Oh, Y. D., Okusawa, T., Orava, R., Ortolan, L., Pagliarone, C., Palencia, E., Palni, P., Papadimitriou, V., Parker, W., Pauletta, G., Paulini, M., Paus, C., Phillips, T. J., Piacentino, G., Pianori, E., Pilot, J., Pitts, K., Plager, C., Pondrom, L., Poprocki, S., Potamianos, K., Prokoshin, F., Pranko, A., Ptohos, F., Punzi, G., Fernández, I. Redondo, Renton, P., Rescigno, M., Rimondi, F., Ristori, L., Robson, A., Rodriguez, T., Rolli, S., Ronzani, M., Roser, R., Rosner, J. L., Ruffini, F., Ruiz, A., Russ, J., Rusu, V., Sakumoto, W. K., Sakurai, Y., Santi, L., Sato, K., Saveliev, V., Savoy-Navarro, A., Schlabach, P., Schmidt, E. E., Schwarz, T., Scodellaro, L., Scuri, F., Seidel, S., Seiya, Y., Semenov, A., Sforza, F., Shalhout, S. Z., Shears, T., Shepard, P. F., Shimojima, M., Shochet, M., Shreyber-Tecker, I., Simonenko, A., Sliwa, K., Smith, J. R., Snider, F. D., Sorin, V., Song, H., Stancari, M., Denis, R. St., Stentz, D., Strologas, J., Sudo, Y., Sukhanov, A., Suslov, I., Takemasa, K., Takeuchi, Y., Tang, J., Tecchio, M., Teng, P. K., Thom, J., Thomson, E., Thukral, V., Toback, D., Tokar, S., Tollefson, K., Tomura, T., Tonelli, D., Torre, S., Torretta, D., Totaro, P., Trovato, M., Ukegawa, F., Uozumi, S., Vázquez, F., Velev, G., Vellidis, C., Vernieri, C., Vidal, M., Vilar, R., Vizán, J., Vogel, M., Volpi, G., Wagner, P., Wallny, R., Wang, S. M., Waters, D., Wester III, W. C., Whiteson, D., Wicklund, A. B., Wilbur, S., Williams, H. H., Wilson, J. S., Wilson, P., Winer, B. L., Wittich, P., Wolbers, S., Wolfe, H., Wright, T., Wu, X., Wu, Z., Yamamoto, K., Yamato, D., Yang, T., Yang, U. K., Yang, Y. C., Yao, W. -M., Yeh, G. P., Yi, K., Yoh, J., Yorita, K., Yoshida, T., Yu, G. B., Yu, I., Zanetti, A. M., Zeng, Y., Zhou, C., and Zucchelli, S.

Subjects
High Energy Physics - Experiment
Abstract

We report on a measurement of the $D^{+}$-meson production cross section as a function of transverse momentum ($p_T$) in proton-antiproton ($p\bar{p}$) collisions at 1.96 TeV center-of-mass energy, using the full data set collected by the Collider Detector at Fermilab in Tevatron Run II and corresponding to 10 fb$^{-1}$ of integrated luminosity. We use $D^{+} \to K^-\pi^+\pi^+$ decays fully reconstructed in the central rapidity region $|y|<1$ with transverse momentum down to 1.5 GeV/$c$, a range previously unexplored in $p\bar{p}$ collisions. Inelastic $p\bar{p}$-scattering events are selected online using minimally-biasing requirements followed by an optimized offline selection. The $K^-\pi^+\pi^+$ mass distribution is used to identify the $D^+$ signal, and the $D^+$ transverse impact-parameter distribution is used to separate prompt production, occurring directly in the hard scattering process, from secondary production from $b$-hadron decays. We obtain a prompt $D^+$ signal of 2950 candidates corresponding to a total cross section $\sigma(D^+, 1.5 < p_T < 14.5~\mbox{GeV/}c, |y|<1) = 71.9 \pm 6.8 (\mbox{stat}) \pm 9.3 (\mbox{syst})~\mu$b. While the measured cross sections are consistent with theoretical estimates in each $p_T$ bin, the shape of the observed $p_T$ spectrum is softer than the expectation from quantum chromodynamics. The results are unique in $p\bar{p}$ collisions and can improve the shape and uncertainties of future predictions., Comment: 8 pages, 3 figures

Published
2016
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45. Measurement of the $WW$ and $WZ$ production cross section using final states with a charged lepton and heavy-flavor jets in the full CDF Run II data set

Author

CDF Collaboration, Aaltonen, T., Amerio, S., Amidei, D., Anastassov, A., Annovi, A., Antos, J., Apollinari, G., Appel, J. A., Arisawa, T., Artikov, A., Asaadi, J., Ashmanskas, W., Auerbach, B., Aurisano, A., Azfar, F., Badgett, W., Bae, T., Barbaro-Galtieri, A., Barnes, V. E., Barnett, B. A., Barria, P., Bartos, P., Bauce, M., Bedeschi, F., Behari, S., Bellettini, G., Bellinger, J., Benjamin, D., Beretvas, A., Bhatti, A., Bland, K. R., Blumenfeld, B., Bocci, A., Bodek, A., Bortoletto, D., Boudreau, J., Boveia, A., Brigliadori, L., Bromberg, C., Brucken, E., Budagov, J., Budd, H. S., Burkett, K., Busetto, G., Bussey, P., Butti, P., Buzatu, A., Calamba, A., Camarda, S., Campanelli, M., Canelli, F., Carls, B., Carlsmith, D., Carosi, R., Carrillo, S., Casal, B., Casarsa, M., Castro, A., Catastini, P., Cauz, D., Cavaliere, V., Cerri, A., Cerrito, L., Chen, Y. C., Chertok, M., Chiarelli, G., Chlachidze, G., Cho, K., Chokheli, D., Clark, A., Clarke, C., Convery, M. E., Conway, J., Corbo, M., Cordelli, M., Cox, C. A., Cox, D. J., Cremonesi, M., Cruz, D., Cuevas, J., Culbertson, R., d'Ascenzo, N., Datta, M., de Barbaro, P., Demortier, L., Marchese, L., Deninno, M., Devoto, F., D'Errico, M., Di Canto, A., Di Ruzza, B., Dittmann, J. R., D'Onofrio, M., Donati, S., Dorigo, M., Driutti, A., Ebina, K., Edgar, R., Erbacher, R., Errede, S., Esham, B., Farrington, S., Ramos, J. P. Fernández, Field, R., Flanagan, G., Forrest, R., Franklin, M., Freeman, J. C., Frisch, H., Funakoshi, Y., Galloni, C., Garfinkel, A. F., Garosi, P., Gerberich, H., Gerchtein, E., Giagu, S., Giakoumopoulou, V., Gibson, K., Ginsburg, C. M., Giokaris, N., Giromini, P., Glagolev, V., Glenzinski, D., Gold, M., Goldin, D., Golossanov, A., Gomez, G., Gomez-Ceballos, G., Goncharov, M., López, O. González, Gorelov, I., Goshaw, A. T., Goulianos, K., Gramellini, E., Grosso-Pilcher, C., Group, R. C., da Costa, J. Guimaraes, Hahn, S. R., Han, J. Y., Happacher, F., Hara, K., Hare, M., Harr, R. F., Harrington-Taber, T., Hatakeyama, K., Hays, C., Heinrich, J., Herndon, M., Hocker, A., Hong, Z., Hopkins, W., Hou, S., Hughes, R. E., Husemann, U., Hussein, M., Huston, J., Introzzi, G., Iori, M., Ivanov, A., James, E., Jang, D., Jayatilaka, B., Jeon, E. J., Jindariani, S., Jones, M., Joo, K. K., Jun, S. Y., Junk, T. R., Kambeitz, M., Kamon, T., Karchin, P. E., Kasmi, A., Kato, Y., Ketchum, W., Keung, J., Kilminster, B., Kim, D. H., Kim, H. S., Kim, J. E., Kim, M. J., Kim, S. B., Kim, S. H., Kim, Y. K., Kim, Y. J., Kimura, N., Kirby, M., Knoepfel, K., Kondo, K., Kong, D. J., Konigsberg, J., Kotwal, A. V., Kreps, M., Kroll, J., Kruse, M., Kuhr, T., Kurata, M., Laasanen, A. T., Lammel, S., Lancaster, M., Lannon, K., Latino, G., Lee, H. S., Lee, J. S., Leo, S., Leone, S., Lewis, J. D., Limosani, A., Lipeles, E., Lister, A., Liu, Q., Liu, T., Lockwitz, S., Loginov, A., Lucà, A., Lucchesi, D., Lueck, J., Lujan, P., Lukens, P., Lungu, G., Lys, J., Lysak, R., Madrak, R., Maestro, P., Malik, S., Manca, G., Manousakis-Katsikakis, A., Margaroli, F., Marino, P., Matera, K., Mattson, M. E., Mazzacane, A., Mazzanti, P., McNulty, R., Mehta, A., Mehtala, P., Mesropian, C., Miao, T., Mietlicki, D., Mitra, A., Miyake, H., Moed, S., Moggi, N., Moon, C. S., Moore, R., Morello, M. J., Mukherjee, A., Muller, Th., Murat, P., Mussini, M., Nachtman, J., Nagai, Y., Naganoma, J., Nakano, I., Napier, A., Nett, J., Nigmanov, T., Nodulman, L., Noh, S. Y., Norniella, O., Oakes, L., Oh, S. H., Oh, Y. D., Okusawa, T., Orava, R., Ortolan, L., Pagliarone, C., Palencia, E., Palni, P., Papadimitriou, V., Parker, W., Pauletta, G., Paulini, M., Paus, C., Phillips, T. J., Piacentino, G., Pianori, E., Pilot, J., Pitts, K., Plager, C., Pondrom, L., Poprocki, S., Potamianos, K., Prokoshin, F., Pranko, A., Ptohos, F., Punzi, G., Fernández, I. Redondo, Renton, P., Rescigno, M., Rimondi, F., Ristori, L., Robson, A., Rodriguez, T., Rolli, S., Ronzani, M., Roser, R., Rosner, J. L., Ruffini, F., Ruiz, A., Russ, J., Rusu, V., Sakumoto, W. K., Sakurai, Y., Santi, L., Sato, K., Saveliev, V., Savoy-Navarro, A., Schlabach, P., Schmidt, E. E., Schwarz, T., Scodellaro, L., Scuri, F., Seidel, S., Seiya, Y., Semenov, A., Sforza, F., Shalhout, S. Z., Shears, T., Shepard, P. F., Shimojima, M., Shochet, M., Shreyber-Tecker, I., Simonenko, A., Sliwa, K., Smith, J. R., Snider, F. D., Sorin, V., Song, H., Stancari, M., Denis, R. St., Stentz, D., Strologas, J., Sudo, Y., Sukhanov, A., Suslov, I., Takemasa, K., Takeuchi, Y., Tang, J., Tecchio, M., Teng, P. K., Thom, J., Thomson, E., Thukral, V., Toback, D., Tokar, S., Tollefson, K., Tomura, T., Tonelli, D., Torre, S., Torretta, D., Totaro, P., Trovato, M., Ukegawa, F., Uozumi, S., Vázquez, F., Velev, G., Vellidis, C., Vernieri, C., Vidal, M., Vilar, R., Vizán, J., Vogel, M., Volpi, G., Wagner, P., Wallny, R., Wang, S. M., Waters, D., Wester III, W. C., Whiteson, D., Wicklund, A. B., Wilbur, S., Williams, H. H., Wilson, J. S., Wilson, P., Winer, B. L., Wittich, P., Wolbers, S., Wolfe, H., Wright, T., Wu, X., Wu, Z., Yamamoto, K., Yamato, D., Yang, T., Yang, U. K., Yang, Y. C., Yao, W. -M., Yeh, G. P., Yi, K., Yoh, J., Yorita, K., Yoshida, T., Yu, G. B., Yu, I., Zanetti, A. M., Zeng, Y., Zhou, C., and Zucchelli, S.

Subjects
High Energy Physics - Experiment
Abstract

We present a measurement of the total {\it WW} and {\it WZ} production cross sections in $p\bar{p}$ collision at $\sqrt{s}=1.96$ TeV, in a final state consistent with leptonic $W$ boson decay and jets originating from heavy-flavor quarks from either a $W$ or a $Z$ boson decay. This analysis uses the full data set collected with the CDF II detector during Run II of the Tevatron collider, corresponding to an integrated luminosity of 9.4 fb$^{-1}$. An analysis of the dijet mass spectrum provides $3.7\sigma$ evidence of the summed production processes of either {\it WW} or {\it WZ} bosons with a measured total cross section of $\sigma_{WW+WZ} = 13.7\pm 3.9$~pb. Independent measurements of the {\it WW} and {\it WZ} production cross sections are allowed by the different heavy-flavor decay-patterns of the $W$ and $Z$ bosons and by the analysis of secondary-decay vertices reconstructed within heavy-flavor jets. The productions of {\it WW} and of {\it WZ} dibosons are independently seen with significances of $2.9\sigma$ and $2.1\sigma$, respectively, with total cross sections of $\sigma_{WW}= 9.4\pm 4.2$~pb and $\sigma_{WZ}=3.7^{+2.5}_{-2.2}$~pb. The measurements are consistent with standard-model predictions., Comment: 19 pages, 11 figures, accepted for publication on Physical Review D

Published
2016
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46. Measurement of $\sin^2\theta^{\rm lept}_{\rm eff}$ using $e^+e^-$ pairs from $\gamma^*/Z$ bosons produced in $p\bar{p}$ collisions at a center-of-momentum energy of 1.96 TeV

Author

CDF Collaboration, Aaltonen, T., Amerio, S., Amidei, D., Anastassov, A., Annovi, A., Antos, J., Apollinari, G., Appel, J. A., Arisawa, T., Artikov, A., Asaadi, J., Ashmanskas, W., Auerbach, B., Aurisano, A., Azfar, F., Badgett, W., Bae, T., Barbaro-Galtieri, A., Barnes, V. E., Barnett, B. A., Barria, P., Bartos, P., Bauce, M., Bedeschi, F., Behari, S., Bellettini, G., Bellinger, J., Benjamin, D., Beretvas, A., Bhatti, A., Bland, K. R., Blumenfeld, B., Bocci, A., Bodek, A., Bortoletto, D., Boudreau, J., Boveia, A., Brigliadori, L., Bromberg, C., Brucken, E., Budagov, J., Budd, H. S., Burkett, K., Busetto, G., Bussey, P., Butti, P., Buzatu, A., Calamba, A., Camarda, S., Campanelli, M., Canelli, F., Carls, B., Carlsmith, D., Carosi, R., Carrillo, S., Casal, B., Casarsa, M., Castro, A., Catastini, P., Cauz, D., Cavaliere, V., Cerri, A., Cerrito, L., Chen, Y. C., Chertok, M., Chiarelli, G., Chlachidze, G., Cho, K., Chokheli, D., Clark, A., Clarke, C., Convery, M. E., Conway, J., Corbo, M., Cordelli, M., Cox, C. A., Cox, D. J., Cremonesi, M., Cruz, D., Cuevas, J., Culbertson, R., d'Ascenzo, N., Datta, M., de Barbaro, P., Demortier, L., Marchese, L., Deninno, M., Devoto, F., D'Errico, M., Di Canto, A., Di Ruzza, B., Dittmann, J. R., D'Onofrio, M., Donati, S., Dorigo, M., Driutti, A., Ebina, K., Edgar, R., Erbacher, R., Errede, S., Esham, B., Farrington, S., Ramos, J. P. Fernández, Field, R., Flanagan, G., Forrest, R., Franklin, M., Freeman, J. C., Frisch, H., Funakoshi, Y., Galloni, C., Garfinkel, A. F., Garosi, P., Gerberich, H., Gerchtein, E., Giagu, S., Giakoumopoulou, V., Gibson, K., Ginsburg, C. M., Giokaris, N., Giromini, P., Glagolev, V., Glenzinski, D., Gold, M., Goldin, D., Golossanov, A., Gomez, G., Gomez-Ceballos, G., Goncharov, M., López, O. González, Gorelov, I., Goshaw, A. T., Goulianos, K., Gramellini, E., Grosso-Pilcher, C., da Costa, J. Guimaraes, Hahn, S. R., Han, J. Y., Happacher, F., Hara, K., Hare, M., Harr, R. F., Harrington-Taber, T., Hatakeyama, K., Hays, C., Heinrich, J., Herndon, M., Hocker, A., Hong, Z., Hopkins, W., Hou, S., Hughes, R. E., Husemann, U., Hussein, M., Huston, J., Introzzi, G., Iori, M., Ivanov, A., James, E., Jang, D., Jayatilaka, B., Jeon, E. J., Jindariani, S., Jones, M., Joo, K. K., Jun, S. Y., Junk, T. R., Kambeitz, M., Kamon, T., Karchin, P. E., Kasmi, A., Kato, Y., Ketchum, W., Keung, J., Kilminster, B., Kim, D. H., Kim, H. S., Kim, J. E., Kim, M. J., Kim, S. B., Kim, S. H., Kim, Y. K., Kim, Y. J., Kimura, N., Kirby, M., Kondo, K., Kong, D. J., Konigsberg, J., Kotwal, A. V., Kreps, M., Kroll, J., Kruse, M., Kuhr, T., Kurata, M., Laasanen, A. T., Lammel, S., Lancaster, M., Lannon, K., Latino, G., Lee, H. S., Lee, J. S., Leo, S., Leone, S., Lewis, J. D., Limosani, A., Lipeles, E., Lister, A., Liu, Q., Liu, T., Lockwitz, S., Loginov, A., Lucà, A., Lucchesi, D., Lueck, J., Lujan, P., Lukens, P., Lungu, G., Lys, J., Lysak, R., Madrak, R., Maestro, P., Malik, S., Manca, G., Manousakis-Katsikakis, A., Margaroli, F., Marino, P., Matera, K., Mattson, M. E., Mazzacane, A., Mazzanti, P., McNulty, R., Mehta, A., Mehtala, P., Mesropian, C., Miao, T., Mietlicki, D., Mitra, A., Miyake, H., Moed, S., Moggi, N., Moon, C. S., Moore, R., Morello, M. J., Mukherjee, A., Muller, Th., Murat, P., Mussini, M., Nachtman, J., Nagai, Y., Naganoma, J., Nakano, I., Napier, A., Nett, J., Nigmanov, T., Nodulman, L., Noh, S. Y., Norniella, O., Oakes, L., Oh, S. H., Oh, Y. D., Okusawa, T., Orava, R., Ortolan, L., Pagliarone, C., Palencia, E., Palni, P., Papadimitriou, V., Parker, W., Pauletta, G., Paulini, M., Paus, C., Phillips, T. J., Piacentino, G., Pianori, E., Pilot, J., Pitts, K., Plager, C., Pondrom, L., Poprocki, S., Potamianos, K., Prokoshin, F., Pranko, A., Ptohos, F., Punzi, G., Fernández, I. Redondo, Renton, P., Rescigno, M., Rimondi, F., Ristori, L., Robson, A., Rodriguez, T., Rolli, S., Ronzani, M., Roser, R., Rosner, J. L., Ruffini, F., Ruiz, A., Russ, J., Rusu, V., Sakumoto, W. K., Sakurai, Y., Santi, L., Sato, K., Saveliev, V., Savoy-Navarro, A., Schlabach, P., Schmidt, E. E., Schwarz, T., Scodellaro, L., Scuri, F., Seidel, S., Seiya, Y., Semenov, A., Sforza, F., Shalhout, S. Z., Shears, T., Shepard, P. F., Shimojima, M., Shochet, M., Shreyber-Tecker, I., Simonenko, A., Sliwa, K., Smith, J. R., Snider, F. D., Sorin, V., Song, H., Stancari, M., Denis, R. St., Stentz, D., Strologas, J., Sudo, Y., Sukhanov, A., Suslov, I., Takemasa, K., Takeuchi, Y., Tang, J., Tecchio, M., Teng, P. K., Thom, J., Thomson, E., Thukral, V., Toback, D., Tokar, S., Tollefson, K., Tomura, T., Tonelli, D., Torre, S., Torretta, D., Totaro, P., Trovato, M., Ukegawa, F., Uozumi, S., Vázquez, F., Velev, G., Vellidis, C., Vernieri, C., Vidal, M., Vilar, R., Vizán, J., Vogel, M., Volpi, G., Wagner, P., Wallny, R., Wang, S. M., Waters, D., Wester III, W. C., Whiteson, D., Wicklund, A. B., Wilbur, S., Williams, H. H., Wilson, J. S., Wilson, P., Winer, B. L., Wittich, P., Wolbers, S., Wolfe, H., Wright, T., Wu, X., Wu, Z., Yamamoto, K., Yamato, D., Yang, T., Yang, U. K., Yang, Y. C., Yao, W. -M., Yeh, G. P., Yi, K., Yoh, J., Yorita, K., Yoshida, T., Yu, G. B., Yu, I., Zanetti, A. M., Zeng, Y., Zhou, C., and Zucchelli, S.

Subjects
High Energy Physics - Experiment
Abstract

At the Fermilab Tevatron proton-antiproton ($p\bar{p}$) collider, Drell-Yan lepton pairs are produced in the process $p \bar{p} \rightarrow e^+e^- + X$ through an intermediate $\gamma^*/Z$ boson. The forward-backward asymmetry in the polar-angle distribution of the $e^-$ as a function of the $e^+e^-$-pair mass is used to obtain $\sin^2\theta^{\rm lept}_{\rm eff}$, the effective leptonic determination of the electroweak-mixing parameter $\sin^2\theta_W$. The measurement sample, recorded by the Collider Detector at Fermilab (CDF), corresponds to 9.4~fb$^{-1}$ of integrated luminosity from $p\bar{p}$ collisions at a center-of-momentum energy of 1.96 TeV, and is the full CDF Run II data set. The value of $\sin^2\theta^{\rm lept}_{\rm eff}$ is found to be $0.23248 \pm 0.00053$. The combination with the previous CDF measurement based on $\mu^+\mu^-$ pairs yields $\sin^2\theta^{\rm lept}_{\rm eff} = 0.23221 \pm 0.00046$. This result, when interpreted within the specified context of the standard model assuming $\sin^2 \theta_W = 1 - M_W^2/M_Z^2$ and that the $W$- and $Z$-boson masses are on-shell, yields $\sin^2\theta_W = 0.22400 \pm 0.00045$, or equivalently a $W$-boson mass of $80.328 \pm 0.024 \;{\rm GeV}/c^2$.

Published
2016
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47. Resistive Plate Chamber Digitization in a Hadronic Shower Environment

Author

Deng, Z., Li, Y., Wang, Y., Yue, Q., Yang, Z., Apostolakis, J., Folger, G., Grefe, C., Ivantchenko, V., Ribon, A., Uzhinskiy, V., Boumediene, D., Carloganu, C., Français, V., Cho, G., Kim, D-W., Lee, S. C., Park, W., Vallecorsa, S., Cauwenbergh, S., Tytgat, M., Pingault, A., Zaganidis, N., Brianne, E., Ebrahimi, A., Gadow, K., Göttlicher, P., Günter, C., Hartbrich, O., Hermberg, B., Irles, A., Krivan, F., Krüger, K., Kvasnicka, J., Lu, S., Lutz, B., Morgunov, V., Neubüser, C., Provenza, A., Reinecke, M., Sefkow, F., Schuwalow, S., Tran, H. L., Garutti, E., Laurien, S., Matysek, M., Ramilli, M., Schroeder, S., Bilki, B., Norbeck, E., Northacker, D., Onel, Y., Chang, S., Khan, A., Kim, D. H., Kong, D. J., Oh, Y. D., Kawagoe, K., Hirai, H., Sudo, Y., Suehara, T., Sumida, H., Yoshioka, T., Gil, E. Cortina, Mannai, S., Buridon, V., Combaret, C., Caponetto, L., Eté, R., Garillot, G., Grenier, G., Han, R., Ianigro, J. C., Kieffer, R., Laktineh, I., Lumb, N., Mathez, H., Mirabito, L., Petrukhin, A., Steen, A., Antequera, J. Berenguer, Alamillo, E. Calvo, Fouz, M. -C., Marin, J., Puerta-Pelayo, J., Verdugo, A., Chadeeva, M., Danilov, M., Gabriel, M., Goecke, P., Kiesling, C., vanderKolk, N., Simon, F., Szalay, M., Bilokin, S., Bonis, J., Cornebise, P., Richard, F., Pöschl, R., Rouëné, J., Thiebault, A., Zerwas, D., Anduze, M., Balagura, V., Belkadhi, K., Boudry, V., Brient, J-C., Cornat, R., Frotin, M., Gastaldi, F., Haddad, Y., Magniette, F., Ruan, M., Rubio-Roy, M., Shpak, K., Videau, H., Yu, D., Callier, S., di Lorenzo, S. Conforti, Dulucq, F., Martin-Chassard, G., de la Taille, Ch., Raux, L., Seguin-Moreau, N., Kotera, K., Ono, H., Takeshita, T., and Corriveau, F.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

The CALICE Semi-Digital Hadron Calorimeter (SDHCAL) technological prototype is a sampling calorimeter using Glass Resistive Plate Chamber detectors with a three-threshold readout as the active medium. This technology is one of the two options proposed for the hadron calorimeter of the International Large Detector for the International Linear Collider. The prototype was exposed to beams of muons, electrons and pions of different energies at the CERN Super Proton Synchrotron. To be able to study the performance of such a calorimeter in future experiments it is important to ensure reliable simulation of its response. In this paper we present our prototype simulation performed with GEANT4 and the digitization procedure achieved with an algorithm called SimDigital. A detailed description of this algorithm is given and the methods to determinate its parameters using muon tracks and electromagnetic showers are explained. The comparison with hadronic shower data shows a good agreement up to 50 GeV. Discrepancies are observed at higher energies. The reasons for these differences are investigated.

Published
2016
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48. Measurement of the forward-backward asymmetry of top-quark and antiquark pairs using the full CDF Run II data set

Author

CDF Collaboration, Aaltonen, T., Amerio, S., Amidei, D., Anastassov, A., Annovi, A., Antos, J., Apollinari, G., Appel, J. A., Arisawa, T., Artikov, A., Asaadi, J., Ashmanskas, W., Auerbach, B., Aurisano, A., Azfar, F., Badgett, W., Bae, T., Barbaro-Galtieri, A., Barnes, V. E., Barnett, B. A., Barria, P., Bartos, P., Bauce, M., Bedeschi, F., Behari, S., Bellettini, G., Bellinger, J., Benjamin, D., Beretvas, A., Bhatti, A., Bland, K. R., Blumenfeld, B., Bocci, A., Bodek, A., Bortoletto, D., Boudreau, J., Boveia, A., Brigliadori, L., Bromberg, C., Brucken, E., Budagov, J., Budd, H. S., Burkett, K., Busetto, G., Bussey, P., Butti, P., Buzatu, A., Calamba, A., Camarda, S., Campanelli, M., Canelli, F., Carls, B., Carlsmith, D., Carosi, R., Carrillo, S., Casal, B., Casarsa, M., Castro, A., Catastini, P., Cauz, D., Cavaliere, V., Cerri, A., Cerrito, L., Chen, Y. C., Chertok, M., Chiarelli, G., Chlachidze, G., Cho, K., Chokheli, D., Clark, A., Clarke, C., Convery, M. E., Conway, J., Corbo, M., Cordelli, M., Cox, C. A., Cox, D. J., Cremonesi, M., Cruz, D., Cuevas, J., Culbertson, R., d'Ascenzo, N., Datta, M., de Barbaro, P., Demortier, L., Marchese, L., Deninno, M., Devoto, F., D'Errico, M., Di Canto, A., Di Ruzza, B., Dittmann, J. R., D'Onofrio, M., Donati, S., Dorigo, M., Driutti, A., Ebina, K., Edgar, R., Erbacher, R., Errede, S., Esham, B., Farrington, S., Ramos, J. P. Fernández, Field, R., Flanagan, G., Forrest, R., Franklin, M., Freeman, J. C., Frisch, H., Funakoshi, Y., Galloni, C., Garfinkel, A. F., Garosi, P., Gerberich, H., Gerchtein, E., Giagu, S., Giakoumopoulou, V., Gibson, K., Ginsburg, C. M., Giokaris, N., Giromini, P., Glagolev, V., Glenzinski, D., Gold, M., Goldin, D., Golossanov, A., Gomez, G., Gomez-Ceballos, G., Goncharov, M., López, O. González, Gorelov, I., Goshaw, A. T., Goulianos, K., Gramellini, E., Grosso-Pilcher, C., da Costa, J. Guimaraes, Hahn, S. R., Han, J. Y., Happacher, F., Hara, K., Hare, M., Harr, R. F., Harrington-Taber, T., Hatakeyama, K., Hays, C., Heinrich, J., Herndon, M., Hocker, A., Hong, Z., Hopkins, W., Hou, S., Hughes, R. E., Husemann, U., Hussein, M., Huston, J., Introzzi, G., Iori, M., Ivanov, A., James, E., Jang, D., Jayatilaka, B., Jeon, E. J., Jindariani, S., Jones, M., Joo, K. K., Jun, S. Y., Junk, T. R., Kambeitz, M., Kamon, T., Karchin, P. E., Kasmi, A., Kato, Y., Ketchum, W., Keung, J., Kilminster, B., Kim, D. H., Kim, H. S., Kim, J. E., Kim, M. J., Kim, S. B., Kim, S. H., Kim, Y. K., Kim, Y. J., Kimura, N., Kirby, M., Kondo, K., Kong, D. J., Konigsberg, J., Kotwal, A. V., Kreps, M., Kroll, J., Kruse, M., Kuhr, T., Kurata, M., Laasanen, A. T., Lammel, S., Lancaster, M., Lannon, K., Latino, G., Lee, H. S., Lee, J. S., Leo, S., Leone, S., Lewis, J. D., Limosani, A., Lipeles, E., Lister, A., Liu, Q., Liu, T., Lockwitz, S., Loginov, A., Lucà, A., Lucchesi, D., Lueck, J., Lujan, P., Lukens, P., Lungu, G., Lys, J., Lysak, R., Madrak, R., Maestro, P., Malik, S., Manca, G., Manousakis-Katsikakis, A., Margaroli, F., Marino, P., Matera, K., Mattson, M. E., Mazzacane, A., Mazzanti, P., McNulty, R., Mehta, A., Mehtala, P., Mesropian, C., Miao, T., Mietlicki, D., Mitra, A., Miyake, H., Moed, S., Moggi, N., Moon, C. S., Moore, R., Morello, M. J., Mukherjee, A., Muller, Th., Murat, P., Mussini, M., Nachtman, J., Nagai, Y., Naganoma, J., Nakano, I., Napier, A., Nett, J., Nigmanov, T., Nodulman, L., Noh, S. Y., Norniella, O., Oakes, L., Oh, S. H., Oh, Y. D., Okusawa, T., Orava, R., Ortolan, L., Pagliarone, C., Palencia, E., Palni, P., Papadimitriou, V., Parker, W., Pauletta, G., Paulini, M., Paus, C., Phillips, T. J., Piacentino, G., Pianori, E., Pilot, J., Pitts, K., Plager, C., Pondrom, L., Poprocki, S., Potamianos, K., Prokoshin, F., Pranko, A., Ptohos, F., Punzi, G., Fernández, I. Redondo, Renton, P., Rescigno, M., Rimondi, F., Ristori, L., Robson, A., Rodriguez, T., Rolli, S., Ronzani, M., Roser, R., Rosner, J. L., Ruffini, F., Ruiz, A., Russ, J., Rusu, V., Sakumoto, W. K., Sakurai, Y., Santi, L., Sato, K., Saveliev, V., Savoy-Navarro, A., Schlabach, P., Schmidt, E. E., Schwarz, T., Scodellaro, L., Scuri, F., Seidel, S., Seiya, Y., Semenov, A., Sforza, F., Shalhout, S. Z., Shears, T., Shepard, P. F., Shimojima, M., Shochet, M., Shreyber-Tecker, I., Simonenko, A., Sliwa, K., Smith, J. R., Snider, F. D., Sorin, V., Song, H., Stancari, M., Denis, R. St., Stentz, D., Strologas, J., Sudo, Y., Sukhanov, A., Suslov, I., Takemasa, K., Takeuchi, Y., Tang, J., Tecchio, M., Teng, P. K., Thom, J., Thomson, E., Thukral, V., Toback, D., Tokar, S., Tollefson, K., Tomura, T., Tonelli, D., Torre, S., Torretta, D., Totaro, P., Trovato, M., Ukegawa, F., Uozumi, S., Vázquez, F., Velev, G., Vellidis, C., Vernieri, C., Vidal, M., Vilar, R., Vizán, J., Vogel, M., Volpi, G., Wagner, P., Wallny, R., Wang, S. M., Waters, D., Wester III, W. C., Whiteson, D., Wicklund, A. B., Wilbur, S., Williams, H. H., Wilson, J. S., Wilson, P., Winer, B. L., Wittich, P., Wolbers, S., Wolfe, H., Wright, T., Wu, X., Wu, Z., Yamamoto, K., Yamato, D., Yang, T., Yang, U. K., Yang, Y. C., Yao, W. -M., Yeh, G. P., Yi, K., Yoh, J., Yorita, K., Yoshida, T., Yu, G. B., Yu, I., Zanetti, A. M., Zeng, Y., Zhou, C., and Zucchelli, S.

Subjects
High Energy Physics - Experiment
Abstract

We measure the forward--backward asymmetry of the production of top quark and antiquark pairs in proton-antiproton collisions at center-of-mass energy $\sqrt{s} = 1.96~\mathrm{TeV}$ using the full data set collected by the Collider Detector at Fermilab (CDF) in Tevatron Run II corresponding to an integrated luminosity of $9.1~\rm{fb}^{-1}$. The asymmetry is characterized by the rapidity difference between top quarks and antiquarks ($\Delta y$), and measured in the final state with two charged leptons (electrons and muons). The inclusive asymmetry, corrected to the entire phase space at parton level, is measured to be $A_{\text{FB}}^{t\bar{t}} = 0.12 \pm 0.13$, consistent with the expectations from the standard-model (SM) and previous CDF results in the final state with a single charged lepton. The combination of the CDF measurements of the inclusive $A_{\text{FB}}^{t\bar{t}}$ in both final states yields $A_{\text{FB}}^{t\bar{t}}=0.160\pm0.045$, which is consistent with the SM predictions. We also measure the differential asymmetry as a function of $\Delta y$. A linear fit to $A_{\text{FB}}^{t\bar{t}}(|\Delta y|)$, assuming zero asymmetry at $\Delta y=0$, yields a slope of $\alpha=0.14\pm0.15$, consistent with the SM prediction and the previous CDF determination in the final state with a single charged lepton. The combined slope of $A_{\text{FB}}^{t\bar{t}}(|\Delta y|)$ in the two final states is $\alpha=0.227\pm0.057$, which is $2.0\sigma$ larger than the SM prediction., Comment: To be submitted to Phys. Rev. D

Published
2016
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49. Measurement of the forward-backward asymmetry in low-mass bottom-quark pairs produced in proton-antiproton collisions

Author

CDF Collaboration, Aaltonen, T., Amerio, S., Amidei, D., Anastassov, A., Annovi, A., Antos, J., Apollinari, G., Appel, J. A., Arisawa, T., Artikov, A., Asaadi, J., Ashmanskas, W., Auerbach, B., Aurisano, A., Azfar, F., Badgett, W., Bae, T., Barbaro-Galtieri, A., Barnes, V. E., Barnett, B. A., Barria, P., Bartos, P., Bauce, M., Bedeschi, F., Behari, S., Bellettini, G., Bellinger, J., Benjamin, D., Beretvas, A., Bhatti, A., Bland, K. R., Blumenfeld, B., Bocci, A., Bodek, A., Bortoletto, D., Boudreau, J., Boveia, A., Brigliadori, L., Bromberg, C., Brucken, E., Budagov, J., Budd, H. S., Burkett, K., Busetto, G., Bussey, P., Butti, P., Buzatu, A., Calamba, A., Camarda, S., Campanelli, M., Canelli, F., Carls, B., Carlsmith, D., Carosi, R., Carrillo, S., Casal, B., Casarsa, M., Castro, A., Catastini, P., Cauz, D., Cavaliere, V., Cerri, A., Cerrito, L., Chen, Y. C., Chertok, M., Chiarelli, G., Chlachidze, G., Cho, K., Chokheli, D., Clark, A., Clarke, C., Convery, M. E., Conway, J., Corbo, M., Cordelli, M., Cox, C. A., Cox, D. J., Cremonesi, M., Cruz, D., Cuevas, J., Culbertson, R., d'Ascenzo, N., Datta, M., de Barbaro, P., Demortier, L., Marchese, L., Deninno, M., Devoto, F., D'Errico, M., Di Canto, A., Di Ruzza, B., Dittmann, J. R., D'Onofrio, M., Donati, S., Dorigo, M., Driutti, A., Ebina, K., Edgar, R., Erbacher, R., Errede, S., Esham, B., Farrington, S., Ramos, J. P. Fernández, Field, R., Flanagan, G., Forrest, R., Franklin, M., Freeman, J. C., Frisch, H., Funakoshi, Y., Galloni, C., Garfinkel, A. F., Garosi, P., Gerberich, H., Gerchtein, E., Giagu, S., Giakoumopoulou, V., Gibson, K., Ginsburg, C. M., Giokaris, N., Giromini, P., Glagolev, V., Glenzinski, D., Gold, M., Goldin, D., Golossanov, A., Gomez, G., Gomez-Ceballos, G., Goncharov, M., López, O. González, Gorelov, I., Goshaw, A. T., Goulianos, K., Gramellini, E., Grosso-Pilcher, C., da Costa, J. Guimaraes, Hahn, S. R., Han, J. Y., Happacher, F., Hara, K., Hare, M., Harr, R. F., Harrington-Taber, T., Hatakeyama, K., Hays, C., Heinrich, J., Herndon, M., Hocker, A., Hong, Z., Hopkins, W., Hou, S., Hughes, R. E., Husemann, U., Hussein, M., Huston, J., Introzzi, G., Iori, M., Ivanov, A., James, E., Jang, D., Jayatilaka, B., Jeon, E. J., Jindariani, S., Jones, M., Joo, K. K., Jun, S. Y., Junk, T. R., Kambeitz, M., Kamon, T., Karchin, P. E., Kasmi, A., Kato, Y., Ketchum, W., Keung, J., Kilminster, B., Kim, D. H., Kim, H. S., Kim, J. E., Kim, M. J., Kim, S. B., Kim, S. H., Kim, Y. K., Kim, Y. J., Kimura, N., Kirby, M., Kondo, K., Kong, D. J., Konigsberg, J., Kotwal, A. V., Kreps, M., Kroll, J., Kruse, M., Kuhr, T., Kurata, M., Laasanen, A. T., Lammel, S., Lancaster, M., Lannon, K., Latino, G., Lee, H. S., Lee, J. S., Leo, S., Leone, S., Lewis, J. D., Limosani, A., Lipeles, E., Lister, A., Liu, Q., Liu, T., Lockwitz, S., Loginov, A., Lucà, A., Lucchesi, D., Lueck, J., Lujan, P., Lukens, P., Lungu, G., Lys, J., Lysak, R., Madrak, R., Maestro, P., Majersky, O., Malik, S., Manca, G., Manousakis-Katsikakis, A., Margaroli, F., Marino, P., Matera, K., Mattson, M. E., Mazzacane, A., Mazzanti, P., McNulty, R., Mehta, A., Mehtala, P., Mesropian, C., Miao, T., Mietlicki, D., Mitra, A., Miyake, H., Moed, S., Moggi, N., Moon, C. S., Moore, R., Morello, M. J., Mukherjee, A., Muller, Th., Murat, P., Mussini, M., Nachtman, J., Nagai, Y., Naganoma, J., Nakano, I., Napier, A., Nett, J., Nigmanov, T., Nodulman, L., Noh, S. Y., Norniella, O., Oakes, L., Oh, S. H., Oh, Y. D., Okusawa, T., Orava, R., Ortolan, L., Pagliarone, C., Palencia, E., Palni, P., Papadimitriou, V., Parker, W., Pauletta, G., Paulini, M., Paus, C., Phillips, T. J., Piacentino, G., Pianori, E., Pilot, J., Pitts, K., Plager, C., Pondrom, L., Poprocki, S., Potamianos, K., Prokoshin, F., Pranko, A., Ptohos, F., Punzi, G., Fernández, I. Redondo, Renton, P., Rescigno, M., Rimondi, F., Ristori, L., Robson, A., Rodriguez, T., Rolli, S., Ronzani, M., Roser, R., Rosner, J. L., Ruffini, F., Ruiz, A., Russ, J., Rusu, V., Sakumoto, W. K., Sakurai, Y., Santi, L., Sato, K., Saveliev, V., Savoy-Navarro, A., Schlabach, P., Schmidt, E. E., Schwarz, T., Scodellaro, L., Scuri, F., Seidel, S., Seiya, Y., Semenov, A., Sforza, F., Shalhout, S. Z., Shears, T., Shepard, P. F., Shimojima, M., Shochet, M., Shreyber-Tecker, I., Simonenko, A., Sliwa, K., Smith, J. R., Snider, F. D., Sorin, V., Song, H., Stancari, M., Denis, R. St., Stentz, D., Strologas, J., Sudo, Y., Sukhanov, A., Suslov, I., Takemasa, K., Takeuchi, Y., Tang, J., Tecchio, M., Teng, P. K., Thom, J., Thomson, E., Thukral, V., Toback, D., Tokar, S., Tollefson, K., Tomura, T., Tonelli, D., Torre, S., Torretta, D., Totaro, P., Trovato, M., Ukegawa, F., Uozumi, S., Vázquez, F., Velev, G., Vellidis, C., Vernieri, C., Vidal, M., Vilar, R., Vizán, J., Vogel, M., Volpi, G., Wagner, P., Wallny, R., Wang, S. M., Waters, D., Wester III, W. C., Whiteson, D., Wicklund, A. B., Wilbur, S., Williams, H. H., Wilson, J. S., Wilson, P., Winer, B. L., Wittich, P., Wolbers, S., Wolfe, H., Wright, T., Wu, X., Wu, Z., Yamamoto, K., Yamato, D., Yang, T., Yang, U. K., Yang, Y. C., Yao, W. -M., Yeh, G. P., Yi, K., Yoh, J., Yorita, K., Yoshida, T., Yu, G. B., Yu, I., Zanetti, A. M., Zeng, Y., Zhou, C., and Zucchelli, S.

Subjects
High Energy Physics - Experiment
Abstract

We report a measurement of the forward-backward asymmetry, $A_{FB}$, in $b\bar{b}$ pairs produced in proton-antiproton collisions and identified by muons from semileptonic $b$-hadron decays. The event sample was collected at a center-of-mass energy of $\sqrt{s}=1.96$ TeV with the CDF II detector and corresponds to 6.9 fb$^{-1}$ of integrated luminosity. We obtain an integrated asymmetry of $A_{FB}(b\bar{b})=(1.2 \pm 0.7)$\% at the particle level for $b$-quark pairs with invariant mass, $m_{b\bar{b}}$, down to $40$ GeV/$c^2$ and measure the dependence of $A_{FB}(b\bar{b})$ on $m_{b\bar{b}}$. The results are compatible with expectations from the standard model., Comment: submitted to Phys. Rev. D

Published
2016

50. Measurement of the $B_c^{\pm}$ production cross section in $p\bar{p}$ collisions at $\sqrt{s}=1.96$ TeV

Author

CDF Collaboration, Aaltonen, T., Amerio, S., Amidei, D., Anastassov, A., Annovi, A., Antos, J., Apollinari, G., Appel, J. A., Arisawa, T., Artikov, A., Asaadi, J., Ashmanskas, W., Auerbach, B., Aurisano, A., Azfar, F., Badgett, W., Bae, T., Barbaro-Galtieri, A., Barnes, V. E., Barnett, B. A., Barria, P., Bartos, P., Bauce, M., Bedeschi, F., Behari, S., Bellettini, G., Bellinger, J., Benjamin, D., Beretvas, A., Bhatti, A., Bland, K. R., Blumenfeld, B., Bocci, A., Bodek, A., Bortoletto, D., Boudreau, J., Boveia, A., Brigliadori, L., Bromberg, C., Brucken, E., Budagov, J., Budd, H. S., Burkett, K., Busetto, G., Bussey, P., Butti, P., Buzatu, A., Calamba, A., Camarda, S., Campanelli, M., Canelli, F., Carls, B., Carlsmith, D., Carosi, R., Carrillo, S., Casal, B., Casarsa, M., Castro, A., Catastini, P., Cauz, D., Cavaliere, V., Cerri, A., Cerrito, L., Chen, Y. C., Chertok, M., Chiarelli, G., Chlachidze, G., Cho, K., Chokheli, D., Clark, A., Clarke, C., Convery, M. E., Conway, J., Corbo, M., Cordelli, M., Cox, C. A., Cox, D. J., Cremonesi, M., Cruz, D., Cuevas, J., Culbertson, R., d'Ascenzo, N., Datta, M., de Barbaro, P., Demortier, L., Marchese, L., Deninno, M., Devoto, F., D'Errico, M., Di Canto, A., Di Ruzza, B., Dittmann, J. R., D'Onofrio, M., Donati, S., Dorigo, M., Driutti, A., Ebina, K., Edgar, R., Erbacher, R., Errede, S., Esham, B., Farrington, S., Ramos, J. P. Fernández, Field, R., Flanagan, G., Forrest, R., Franklin, M., Freeman, J. C., Frisch, H., Funakoshi, Y., Galloni, C., Garfinkel, A. F., Garosi, P., Gerberich, H., Gerchtein, E., Giagu, S., Giakoumopoulou, V., Gibson, K., Ginsburg, C. M., Giokaris, N., Giromini, P., Glagolev, V., Glenzinski, D., Gold, M., Goldin, D., Golossanov, A., Gomez, G., Gomez-Ceballos, G., Goncharov, M., López, O. González, Gorelov, I., Goshaw, A. T., Goulianos, K., Gramellini, E., Grosso-Pilcher, C., da Costa, J. Guimaraes, Hahn, S. R., Han, J. Y., Happacher, F., Hara, K., Hare, M., Harr, R. F., Harrington-Taber, T., Hartz, M., Hatakeyama, K., Hays, C., Heinrich, J., Herndon, M., Hocker, A., Hong, Z., Hopkins, W., Hou, S., Hughes, R. E., Husemann, U., Hussein, M., Huston, J., Introzzi, G., Iori, M., Ivanov, A., James, E., Jang, D., Jayatilaka, B., Jeon, E. J., Jindariani, S., Jones, M., Joo, K. K., Jun, S. Y., Junk, T. R., Kambeitz, M., Kamon, T., Karchin, P. E., Kasmi, A., Kato, Y., Ketchum, W., Keung, J., Kilminster, B., Kim, D. H., Kim, H. S., Kim, J. E., Kim, M. J., Kim, S. B., Kim, S. H., Kim, Y. K., Kim, Y. J., Kimura, N., Kirby, M., Knoepfel, K., Kondo, K., Kong, D. J., Konigsberg, J., Kotwal, A. V., Kreps, M., Kroll, J., Kruse, M., Kuhr, T., Kurata, M., Laasanen, A. T., Lammel, S., Lancaster, M., Lannon, K., Latino, G., Lee, H. S., Lee, J. S., Leo, S., Leone, S., Lewis, J. D., Limosani, A., Lipeles, E., Lister, A., Liu, Q., Liu, T., Lockwitz, S., Loginov, A., Lucà, A., Lucchesi, D., Lueck, J., Lujan, P., Lukens, P., Lungu, G., Lys, J., Lysak, R., Madrak, R., Maestro, P., Malik, S., Manca, G., Manousakis-Katsikakis, A., Margaroli, F., Marino, P., Matera, K., Mattson, M. E., Mazzacane, A., Mazzanti, P., McNulty, R., Mehta, A., Mehtala, P., Mesropian, C., Miao, T., Mietlicki, D., Mitra, A., Miyake, H., Moed, S., Moggi, N., Moon, C. S., Moore, R., Morello, M. J., Mukherjee, A., Muller, Th., Murat, P., Mussini, M., Nachtman, J., Nagai, Y., Naganoma, J., Nakano, I., Napier, A., Nett, J., Nigmanov, T., Nodulman, L., Noh, S. Y., Norniella, O., Oakes, L., Oh, S. H., Oh, Y. D., Okusawa, T., Orava, R., Ortolan, L., Pagliarone, C., Palencia, E., Palni, P., Papadimitriou, V., Parker, W., Pauletta, G., Paulini, M., Paus, C., Phillips, T. 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Subjects
High Energy Physics - Experiment
Abstract

We describe a measurement of the ratio of the cross sections times branching fractions of the $B_c^+$ meson in the decay mode $B_c^+ \rightarrow J/\psi \mu\nu$ to the $B^+$ meson in the decay mode $B^+ \rightarrow J/\psi K^+$ in proton-antiproton collisions at center-of-mass energy $\sqrt{s}=1.96$ TeV. The measurement is based on the complete CDF Run II data set, which comes from an integrated luminosity of $8.7\,{\rm fb}^{-1}$. The ratio of the production cross sections times branching fractions for $B_c^+$ and $B_c^+$ mesons with momentum transverse to the beam greater than $6~\textrm{GeV}/c$ and rapidity magnitude smaller than 0.6 is $0.211\pm 0.012~\mbox{(stat)}^{+0.021}_{-0.020}~\mbox{(syst)}$. Using the known $B^+ \rightarrow J/\psi K^+$ branching fraction, the known $B^+$ production cross section, and a selection of the predicted $B_c^+ \rightarrow J/\psi \mu\nu$ branching fractions, the range for the total $B_c^+$ production cross section is estimated., Comment: 28 pages, 25 figures, and 20 tables. This version is consistent with paper published in Phys. Rev. D on March 1, 2016

Published
2016
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