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155 results on '"Kongyingyoes, Bunkerd"'

21. Human papillomavirus (HPV) infection in a case-control study of oral squamous cell carcinoma and its increasing trend in northeastern Thailand

Author

Phusingha, Pensiri, primary, Ekalaksananan, Tipaya, additional, Vatanasapt, Patravoot, additional, Loyha, Kulchaya, additional, Promthet, Supannee, additional, Kongyingyoes, Bunkerd, additional, Patarapadungkit, Natcha, additional, Chuerduangphui, Jureeporn, additional, and Pientong, Chamsai, additional

Published
2016
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22. Rice bran protein hydrolysates attenuate diabetic nephropathy in diabetic animal model

Author

Boonloh, Kampeebhorn, primary, Lee, Eun Soo, additional, Kim, Hong Min, additional, Kwon, Mi Hye, additional, Kim, You Mi, additional, Pannangpetch, Patchareewan, additional, Kongyingyoes, Bunkerd, additional, Kukongviriyapan, Upa, additional, Thawornchinsombut, Supawan, additional, Lee, Eun Young, additional, Kukongviriyapan, Veerapol, additional, and Chung, Choon Hee, additional

Published
2016
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24. E6D25E, HPV16 Asian variant shows specific proteomic pattern correlating in cells transformation and suppressive innate immune response

Author

Chopjitt, Peechanika, primary, Pientong, Chamsai, additional, Sunthamala, Nuchsupha, additional, Kongyingyoes, Bunkerd, additional, Haonon, Ornuma, additional, Boonmars, Thidarut, additional, Kikawa, Satomi, additional, Nakahara, Tomomi, additional, Kiyono, Tohru, additional, and Ekalaksananan, Tipaya, additional

Published
2016
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26. Possible contributing role of Epstein-Barr virus (EBV) as a cofactor in human papillomavirus (HPV)-associated cervical carcinogenesis

Author

Aromseree, Sirinart, primary, Pientong, Chamsai, additional, Swangphon, Piyawut, additional, Chaiwongkot, Arkom, additional, Patarapadungkit, Natcha, additional, Kleebkaow, Pilaiwan, additional, Tungsiriwattana, Thumwadee, additional, Kongyingyoes, Bunkerd, additional, Vendrig, Tineke, additional, Middeldorp, Jaap M., additional, and Ekalaksananan, Tipaya, additional

Published
2015
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29. Up-Regulation of miR-21 Is Associated with Cervicitis and Human Papillomavirus Infection in Cervical Tissues

Author

Bumrungthai, Sureewan, primary, Ekalaksananan, Tipaya, additional, Evans, Mark Francis, additional, Chopjitt, Peechanika, additional, Tangsiriwatthana, Thumwadee, additional, Patarapadungkit, Natcha, additional, Kleebkaow, Pilaiwan, additional, Luanratanakorn, Sanguanchoke, additional, Kongyingyoes, Bunkerd, additional, Worawichawong, Suchin, additional, and Pientong, Chamsai, additional

Published
2015
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35. Aberrant gene promoter methylation of E-cadherin, p16 INK4a , p14 ARF , and MGMT in Epstein-Barr virus-associated oral squamous cell carcinomas.

Author

Burassakarn, Ati, Pientong, Chamsai, Sunthamala, Nuchsupha, Chuerduangphui, Jureeporn, Vatanasapt, Patravoot, Patarapadungkit, Natcha, Kongyingyoes, Bunkerd, and Ekalaksananan, Tipaya

Abstract

The etiology of oral carcinogenesis appears to be multifactorial. There is emerging evidence of the presence of Epstein-Barr virus (EBV) in epithelial oral squamous cell carcinoma (OSCC), but an association of EBV with oral carcinogenesis has not yet been established. Although epigenetic alterations, such as aberrant DNA methylation, are known to contribute to the pathogenesis of oral cancer, the relationship of such alterations with EBV infection is little known. This study aimed to investigate the association between EBV infection and promoter methylation patterns of tumor-associated genes in OSCC tissues. A total of 165 of formalin-fixed paraffin-embedded OSCC tissues were studied (68 of EBV positive and 97 of EBV negative). The promoter methylation patterns were investigated for four tumor-associated genes, E-cadherin, p16 INK4a , p14 ARF , and MGMT, by using methylation-specific polymerase chain reaction (MSP). The frequencies of gene promoter hypermethylation in all cases were 47.3% for E-cadherin, 92.7% for p16 INK4a , 74.5% for p14 ARF , and 35.8% for MGMT. Interestingly, most of the analyzed gene promoters were more frequently hypermethylated in EBV-positive than EBV-negative cases, in particular the E-cadherin (56/22) and MGMT (38/21) gene promoters (p < 0.05). Concomitantly, hypermethylation of multiple gene promoters (≥3) was encountered more frequently in EBV-positive samples. Hypermethylation of the E-cadherin promoter associated with EBV was more frequently observed in moderately and poorly differentiated OSCC tissues. These results indicate that epigenetic changes frequently occur in OSCCs and may partly be induced by EBV infection, therefore, EBV may involve in development and progression of the OSCCs. [ABSTRACT FROM AUTHOR]

Published
2017
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36. Human papillomavirus (HPV) infection in a case-control study of oral squamous cell carcinoma and its increasing trend in northeastern Thailand.

Author

Phusingha, Pensiri, Ekalaksananan, Tipaya, Vatanasapt, Patravoot, Loyha, Kulchaya, Promthet, Supannee, Kongyingyoes, Bunkerd, Patarapadungkit, Natcha, Chuerduangphui, Jureeporn, and Pientong, Chamsai

Abstract

Human papillomavirus (HPV) is an independent risk factor for development of oral squamous cell carcinoma (OSCC). This study aimed to investigate the role of HPV infection and the trend in percentage of HPV-associated OSCC over a 5-year period in northeastern Thailand. In this case-control study, 91 exfoliated oral cell samples and 80 lesion cell samples from OSCC cases and exfoliated oral cells from 100 age/gender-matched controls were collected. HPV infection was investigated by PCR using GP5+/GP6+ primers followed by HPV genotyping using reverse line blot hybridization. Quantitative RT-PCR was used to evaluate HPV oncogene transcription. Temporal trends of HPV infection were evaluated in archived formalin-fixed paraffin-embedded (FFPE) OSCC tissues using in situ hybridization. HPV DNA was found in 17.5% (14/80) of lesion samples from OSCC cases and 29.7% (27/91) of exfoliated oral cell samples from the same cases. These values were significantly higher than in exfoliated oral cell samples from controls (13%, 13/100). HPV-16 was the genotype most frequently found in OSCC cases (92.8%, 13/14 infected cases). Interestingly, HPV oncogene mRNA expression was detected and correlated with OSCC cases ( P < 0.005). Of 146 archived FFPE OSCC samples, 82 (56.2%) were positive for high-risk HPV DNA and 64 (43.8%) cases were positive for HPV E6/E7 mRNA expression. There was a trend of increasing percentage of HPV-associated OSCC from 2005 to 2010. This was especially so for females with well-differentiated tumors in specific tongue sub-sites. We suggest that HPV infection plays an important role in oral carcinogenesis in northeastern Thailand. [ABSTRACT FROM AUTHOR]

Published
2017
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42. Differential methylation of E2 binding sites in episomal and integrated HPV 16 genomes in preinvasive and invasive cervical lesions

Author

Chaiwongkot, Arkom, primary, Vinokurova, Svetlana, additional, Pientong, Chamsai, additional, Ekalaksananan, Tipaya, additional, Kongyingyoes, Bunkerd, additional, Kleebkaow, Pilaiwan, additional, Chumworathayi, Bandit, additional, Patarapadungkit, Natcha, additional, Reuschenbach, Miriam, additional, and von Knebel Doeberitz, Magnus, additional

Published
2012
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50. Insulin secretion enhancing activity of roselle calyx extract in normal and streptozotocin-induced diabetic rats.

Author

Wisetmuen, Eamruthai, Pannangpetch, Patchareewan, Kongyingyoes, Bunkerd, Kukongviriyapan, Upa, Yutanawiboonchai, Wiboonchai, and Itharat, Arunporn

Subjects
PHYSIOLOGICAL effects of insulin, INSULIN therapy, CALYX, THERAPEUTIC use of plant extracts, STREPTOZOTOCIN, TREATMENT of diabetes, RAT diseases, PHYSIOLOGY
Abstract

Background and Objective: Our recent study revealed the antihyperglycemic activity of an ethanolic extract of roselle calyxes (Hibiscus sabdariffa) in diabetic rats. The present study had, therefore, an objective to investigate the mechanism underlying this activity. Materials and Methods: Male Sprague Dawley rats were induced to be diabetes by intraperitoneal injection of 45 mg/kg streptozotocin (STZ). Normal rats as well as diabetic rats were administered with the ethanolic extract of H. sabdariffa calyxes (HS-EE) at 0.1 and 1.0 g/kg/day, respectively, for 6 weeks. Then, blood glucose and insulin levels, at basal and glucose-stimulated secretions, were measured. The pancreas was dissected to examine histologically. Results: HS-EE 1.0 g/kg/day significantly decreased the blood glucose level by 38 ± 12% in diabetic rats but not in normal rats. In normal rats, treatment with 1.0 g/kg HS-EE increased the basal insulin level significantly as compared with control normal rats (1.28 ± 0.25 and 0.55 ± 0.05 ng/ml, respectively). Interestingly, diabetic rats treated with 1.0 g/kg HS-EE also showed a significant increase in basal insulin level as compared with the control diabetic rats (0.30 ± 0.05 and 0.15 ± 0.01 ng/ml, respectively). Concerning microscopic histological examination, HS-EE 1.0 g/kg significantly increased the number of islets of Langerhans in both normal rats (1.2 ± 0.1 and 2.0 ± 0.1 islet number/10 low-power fields (LPF) for control and HS-EE treated group, respectively) and diabetic rats (1.0 ± 0.3 and 3.9 ± 0.6 islet number/10 LPF for control and HS-EE treated group, respectively). Conclusion: The antidiabetic activity of HS-EE may be partially mediated via the stimulating effect on insulin secretion. [ABSTRACT FROM AUTHOR]

Published
2013
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