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Ferroptosis is a cell death process caused by redox imbalance in the cell environment. However, the cell death pathway proves beneficial in anticancer therapy, so compounds inducing ferroptosis are sought. The paper presents a newly synthesized iron complex named FeT, composed of ferricyanide and tartrate, which seems to meet these expectations. It is relatively stable, easily soluble in water and capable of peroxidating unsaturated fatty acids. T24 bladder cells were used as model cells. Preliminary studies demonstrated a strong inhibitory effect of this compound on cell proliferation. The cytotoxicity of FeT was assessed. Independently, it initiates caspase activity, indicating the complex cellular impact of this compound. This effect is compellingly the result of FeT penetration into the cell's interior with possible direct damage to mitochondria, thus explaining the involvement of apoptosis in cell death. At the same time, after penetrating into the cell, it causes an increase in reactive oxygen species (ROS), lipid peroxidation and a decrease in reduced glutathione, which is interpreted as to cause ferroptosis. In turn, reducing mitochondrial potential may indicate both ferroptosis and an internal pathway to apoptosis. [ABSTRACT FROM AUTHOR]

In collaborative wayfinding, partners jointly search the environment for task-relevant information. Studies on collaborative search suggest that it is most efficient to divide the search space so that each partner monitors only the space in front of herself. Cooperation, in contrast, requires the establishment of a perceptual common ground to coordinate actions. This is achieved by tracking the partner's perspective. To investigate these conflicting demands, we used mobile eye tracking and compared gaze behavior during individual and collaborative wayfinding. We introduce gaze angle analysis, a way of analyzing eye tracking data with respect to gaze direction. Our results show that partners, compared to individuals, shift their gazes towards their partner's side. This supports perspective tracking and contradicts spatial division-of-labor. [ABSTRACT FROM AUTHOR]

The article addresses a method proposed for comprehensive research of vibration properties dedicated to new structural materials. The method in question comprises three-stage studies, thus enabling the related costs to be reduced on each stage of the process. Subjects of identification and assessment are both the properties and the material structure as well as numerically determined dynamic characteristics and actual vibration characteristics of materials. The article provides preliminary research results obtained for Cu-2Ti-1Co and Cu-6Ti-1Co alloys, the mechanical properties of which are very prospective. An additional advantage of the method proposed is the capability of identifying alloy types by application of non-destructive vibratory methods.

The article addresses results of analyses of design solutions and materials commonly used in gas springs for hydropneumatic suspension systems. The authors have discussed main advantages resulting from application of such a design solution in passenger car suspension systems. Fundamental correlations defining the parameters characterising a gas spring with constant gas mass have been referred to. Also materials used in the manufacture of selected gas spring elements have been described

The paper presented results of the research on process of production of highly important element of passenger car. The main object of the research was influence of production process and material factors on fatigue strength of tubular stabilizer bar. The scope of the research included the stabilizer bar hot bent at the bending table, hardened in oil and tempered. The bending radii I, II and III were metalographically tested. The stabilizer bar was also subjected to fatigue tests. For analysis purpose the finite element method (FEM) calculation have been conducted. The analysis of relationship of outer diameter to wall thickness is very important. The analysed bar has broken early. The paper presents the reasons for premature failure of the tubular stabilizer bar.

Autogenous laser welding of 0.8 mm thick butt joints of car body electro-galvanized steel sheet DC04 was investigated. The Yb:YAG disk laser TruDisk 3302 with the beam spot diameter of 200 μm was used. The effect of laser welding parameters and technological conditions on weld shape, penetration depth, process stability, microstructure and mechanical performance was determined. It was found that the laser beam spot focused on the top surface of a butt joint tends to pass through the gap, especially in the low range of heat input and high welding speed. All test welds were welded at a keyhole mode, and the weld metal was free of porosity. Thus, the keyhole laser welding of zinc coated steel sheets in butt configuration provides excellent conditions to escape for zinc vapours, with no risk of porosity. Microstructure, microhardness and mechanical performance of the butt joints depend on laser welding conditions thus cooling rate and cooling times. The shortest cooling time t8/5 was calculated for 0.29 s.

The paper provides an analysis of the reasons for excessive wear of the camshafts system components based on models developed to describe the impact of selected material, technological and operational factors. The subject of the research was wear of camshaft cams studied in accordance with results of operation tests. Based on the said tests, the dependence of wear intensity of cams from their angular position was established. The respective calculation results enabled the function of cam fallibility to be determined.