9 results on '"Koning Boudewijnstichting"'
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2. De sociale lift blijft steken
- Author
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Koning Boudewijnstichting, Jacobs, Dirk, Rea, Andrea, Teney, Céline, Callier, Louise, Lothaire, Sandrine, Koning Boudewijnstichting, Jacobs, Dirk, Rea, Andrea, Teney, Céline, Callier, Louise, and Lothaire, Sandrine
- Abstract
Analyse der Gründe der schlechteren schulischen Leistungen von Schülern ausländischer Herkunft. Analyse der PISA-Studie 2006: ungleiche Bildungschancen, Segregation im Bildungswesen, Notwendigkeit von mehr Demokratisierung der Schulen und von mehr sozialer Mobilität., Analysis of the reasons why pupils of migrant origin are less successful at school. Analysis of the 2006 PISA research: inequal opportunities, segregation in education, need for ongoing democratization of schools and for more social mobility.
- Published
- 2009
3. Prestaties van de leerlingen van buitenlandse herkomst in België volgens de PISA-studie: vergelijking tussen de Franse Gemeenschap en de Vlaamse Gemeenschap
- Author
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Koning Boudewijnstichting, Jacobs, Dirk, Rea, Andrea, Hanquinet, Laurie, Koning Boudewijnstichting, Jacobs, Dirk, Rea, Andrea, and Hanquinet, Laurie
- Published
- 2009
4. Performances des élèves issus de l'immigration en Belgique selon l'étude PISA: une comparaison entre la Belgique francophone et la Flandre
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Seminarie Koning Boudewijnstichting (6 December 2006: Brussel Brussel), Jacobs, Dirk, Seminarie Koning Boudewijnstichting (6 December 2006: Brussel Brussel), and Jacobs, Dirk
- Abstract
info:eu-repo/semantics/nonPublished
- Published
- 2006
5. Cyclostratigraphy of the Middle to Upper Ordovician successions of the Armorican Massif (western France) using portable X-ray fluorescence
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Matthias Sinnesael, Alfredo Loi, Marie-Pierre Dabard, Thijs R. A. Vandenbroucke, Philippe Claeys, Vrije Universiteit Brussel (VUB), Universiteit Gent = Ghent University (UGENT), Institut de Mécanique Céleste et de Calcul des Ephémérides (IMCCE), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Lille-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Cagliari = University of Cagliari (UniCa), Géosciences Rennes (GR), Université de Rennes (UR)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR), Université de Rennes (UR)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centre National de la Recherche Scientifique (CNRS), Fonds Wetenschappelijk Onderzoek (grant no. FWOTM782), Fondazione Banco di Sardegna (grant nos. F74I19000960007 and F75F21001270007), the Koning Boudewijnstichting (Professor T. Van Autenboer Fund), Universiteit Gent (grant no. BOF17/STA/013), Vrije Universiteit Brussel (VUB Strategic Research Program), European Project: 291300,EC:FP7:ERC,ERC-2011-ADG_20110209,ASTROGEOBIOSPHERE(2012), Analytical, Environmental & Geo-Chemistry, Earth System Sciences, and Chemistry
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[SDU.STU.CL]Sciences of the Universe [physics]/Earth Sciences/Climatology ,[SDU.STU.GC]Sciences of the Universe [physics]/Earth Sciences/Geochemistry ,[SDU]Sciences of the Universe [physics] ,[SDU.STU.ST]Sciences of the Universe [physics]/Earth Sciences/Stratigraphy - Abstract
To expand traditional cyclostratigraphic numerical methods beyond their common technical limitations and apply them to truly deep-time archives, we need to reflect on the development of new approaches to sedimentary archives that are not traditionally targeted for cyclostratigraphic analysis but that frequently occur in the impoverished deep-time record. Siliciclastic storm-dominated shelf environments are a good example of such records. Our case study focuses on the Middle to Upper Ordovician siliciclastic successions of the Armorican Massif (western France) that are well-studied examples in terms of sedimentology and sequence stratigraphy. In addition, these sections are protected geological heritage due to the extraordinary quality of the outcrops. We therefore tested the performance of non-destructive high-resolution (centimeter-scale) portable X-ray fluorescence and natural gamma-ray analyses on an outcrop to obtain major and trace element compositions. Despite the challenging outcrop conditions in the tidal beach zone, our geochemical analyses provide useful information regarding general lithology and several specific sedimentary features such as the detection of paleo-placers or the discrimination between different types of diagenetic concretions such as nodules. Secondly, these new high-resolution data are used to experiment with the application of commonly used numerical cyclostratigraphic techniques on this siliciclastic storm-dominated shelf environment, a non-traditional sedimentological setting for cyclostratigraphic analysis. In the parts of the section with a relatively homogeneous lithology, spectral power analyses and bandpass filtering hint towards a potential astronomical imprint of some sedimentary cycles, but this needs further confirmation in the absence of more robust independent age constraints.
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- 2022
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6. Preclinical evaluation of CDK4 phosphorylation predicts high sensitivity of pleural mesotheliomas to CDK4/6 inhibition
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Sabine Paternot, Eric Raspé, Clément Meiller, Maxime Tarabichi, Jean‐Baptiste Assié, Frederick Libert, Myriam Remmelink, Xavier Bisteau, Patrick Pauwels, Yuna Blum, Nolwenn Le Stang, Séverine Tabone‐Eglinger, Françoise Galateau‐Sallé, Christophe Blanquart, Jan P. Van Meerbeeck, Thierry Berghmans, Didier Jean, Pierre P. Roger, Institut de Recherche Interdisciplinaire en Biologie Humaine et moléculaire = Insitute of Interdisciplinary Research [Bruxelles, Belgique] (IRIBHM), Faculté de Médecine [Bruxelles] (ULB), Université libre de Bruxelles (ULB)-Université libre de Bruxelles (ULB), Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité), Clinical Epidemiology and Ageing : Geriatrie Soins Primaires et Santé Publique (CEpiA), Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Hôpital Erasme [Bruxelles] (ULB), Antwerp University Hospital [Edegem] (UZA), Institut de Génétique et Développement de Rennes (IGDR), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Centre Léon Bérard [Lyon], Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes-Angers (CRCI2NA ), Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Institut Jules Bordet [Bruxelles], Chancellerie des Universités de Paris, Fondation pour la Recherche Médicale, Innoviris, Institut National de la Santé et de la Recherche Médicale, Institut National Du Cancer, Koning Boudewijnstichting, Ligue Contre le Cancer, 2014‐130, Stichting Tegen Kanker, and Centre National de la Recherche Scientifique
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Mesothelioma ,Cancer Research ,palbociclib ,Oncology ,[SDV]Life Sciences [q-bio] ,CDK4 Thr172-phosphorylation ,senescence-associated secretory phenotype ,Genetics ,biomarker ,Molecular Medicine ,cell cycle ,General Medicine ,Human medicine - Abstract
International audience; Malignant pleural mesothelioma (MPM) is an aggressive cancer with limited therapeutic options. We evaluated the impact of CDK4/6 inhibition by palbociclib in 28 MPM cell lines including 19 patient-derived ones, using various approaches including RNA-sequencing. Palbociclib strongly and durably inhibited the proliferation of 23 cell lines, indicating a unique sensitivity of MPM to CDK4/6 inhibition. When observed, insensitivity to palbociclib was mostly explained by the lack of active T172-phosphorylated CDK4. This was associated with high p16(INK4A) (CDKN2A) levels that accompany RB1 defects or inactivation, or (unexpectedly) CCNE1 overexpression in the presence of wild-type RB1. Prolonged palbociclib treatment irreversibly inhibited proliferation despite re-induction of cell cycle genes upon drug washout. A senescence-associated secretory phenotype including various potentially immunogenic components was irreversibly induced. Phosphorylated CDK4 was detected in 80% of 47 MPMs indicating their sensitivity to CDK4/6 inhibitors. Its absence in some highly proliferative MPMs was linked to very high p16 (CDKN2A) expression, which was also observed in public datasets in tumors from short survival patients. Our study supports the evaluation of CDK4/6 inhibitors for MPM treatment, in monotherapy or combination therapy.
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- 2022
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7. Tumor vessel co-option probed by single-cell analysis
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Steven Van Laere, Mieke Dewerchin, Lena-Christin Conradi, Peter Carmeliet, Anna Rita Cantelmo, Federico Taverna, Massimiliano Mazzone, Yonglun Luo, Stefan Vinckier, Stefaan J. Soenen, Nuphar Veiga, Tobias K. Karakach, Peter B. Vermeulen, Lucas Treps, Joanna Kalucka, Sébastien J. Dumas, Luc Dirix, Elda Meta, Shawez Khan, Vincent Geldhof, Guy Eelen, Laure-Anne Teuwen, Luc Schoonjans, Nadine V. Conchinha, Katerina Rohlenova, Lisa M. Becker, Anne Cuypers, Melissa García-Caballero, Laura P.M.H. de Rooij, Jacob Amersfoort, [Teuwen,LA, De Roji,PMH, Cuypers,A, Rohlenova,A, Dumas,SH, García-Caballero,M, Meta,E, Amersfoort,J, Taverna,F, Becker,LM, Veiga,N, Cantelmo,AR, Geldhof,V, Conchinha,NV, Kalucka,J, Treps,L, Conradi,LC, Khan,S, Karakach,TK, Vinckier,S, Schoonjans,L, Eelen,G, Dewerchin,M, Carmeliet,P] Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology (CCB), VIB, Department of Oncology, Leuven Cancer Institute, KU Leuven, Leuven, Belgium. [Teuwen,LA, Van Laere,S, Dirix,L, Vermeulen,P] Translational Cancer Research Unit, GZA Hospitals Sint-Augustinus, Antwerp, Belgium. [Teuwen,LA, Vermeulen,P] Center for Oncological Research, University of Antwerp, Antwerp, Belgium. [Soenen,S] NanoHealth and Optical Imaging Group, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium. [Schoonjans,L, Carmeliet,P] State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, Guangdong, P.R. China. [Mazzone,M] Laboratory of Tumor Inflammation and Angiogenesis, CCB, VIB, Department of Oncology, Leuven Cancer Institute, KU Leuven, Leuven, Belgium. [Luo,Y] Department of Biomedicine, Aarhus University, Aarhus, Denmark. [Luo,Y] Lars Bolund Institute of Regenerative Medicine, BGI-Qingdao, Qingdao, P.R. China. [Luo,Y] BGI-Shenzhen, Shenzhen, China. [Luo,Y] China National GeneBank, BGI-Shenzhen, Shenzhen, P.R. China. [Carmeliet,P] Laboratory of Angiogenesis and Vascular Heterogeneity, Department of Biomedicine, Aarhus University, Aarhus, Denmark. [Rohlenova,K] Institute of Biotechnology of the Czech Academy of Sciences, Praha – za´ pad, Central Bohemia, Czechia. [García-Caballero,M] Department of Molecular Biology and Biochemistry, Faculty of Sciences, and IBIMA (Biomedical Research Institute of Málaga), University of Málaga, Andalucía Tech, Málaga, Spain. [Cantelmo,AR] Laboratory of Cell Physiology, Lille University, Villeneuve d’Ascq, France. [Kalucka,J] Aarhus Institute of Advanced Studies (AIAS), Department of Biomedicine, Aarhus University, Aarhus, Denmark. [Conradi,LC] Clinic of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany. [Khan,S] National Center for Cancer Immune Therapy (CCIT-DK), Department of Oncology, Copenhagen University Hospital, Herlev, Denmark. [Karakach,TK] Bioinformatics Core Laboratory, Children’s Hospital Research Institute of Manitoba, Winnipeg, Canada. [Karakach,TK] Rady Faculty of Health Sciences, Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba Canada., L.-A.T., L.D., S.V.L., and P.V. are supported by Fonds Oncologie Augustinus-Koning Boudewijnstichting and GZA Ziekenhuizen, A.C., K.R., N.V.C., L.P.M.H.d.R., and L.T. by the Fonds Wetenschappelijk Onderzoek (FWO), S.J.D. by a Marie Curie-IEF fellowship, V.G. by Strategisch Basisonderzoek FWO (SB-FWO), Y.L. by BGI-Research, Danish Research Council for Independent Research (DFF-1337-00128), Sapere Aude Young Research Talent Prize (DFF-1335–00763A), and Aarhus University Strategic Grant (AU-iCRISPR), and and P.C. by Methusalem funding (Flemish government), Fund for Scientific Research-Flanders (FWO-Vlaanderen), Foundation Against Cancer (2016-078), Kom op tegen Kanker (Stand up to Cancer, Flemish Cancer Society), European Research Council (ERC Proof of Concept grant ERC-713758 and Advanced ERC Research grant EU-ERC743074), and a NNF Laureate Research Grant from Novo Nordisk Foundation (NNF19OC0055802).
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Anatomy::Cells::Cells, Cultured::Cell Line::Cell Line, Tumor [Medical Subject Headings] ,0301 basic medicine ,Lung Neoplasms ,Diseases::Neoplasms::Neoplasms by Site::Urogenital Neoplasms::Urologic Neoplasms::Kidney Neoplasms [Medical Subject Headings] ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Cytological Techniques::Single-Cell Analysis [Medical Subject Headings] ,Vascular permeability ,Metastasis ,Transcriptome ,anti-angiogenic therapy ,Mice ,0302 clinical medicine ,Single-cell analysis ,Neoplasms ,Organisms::Eukaryota::Animals [Medical Subject Headings] ,Anatomy::Cells::Epithelial Cells::Endothelial Cells [Medical Subject Headings] ,Macrophage ,Myeloid Cells ,Biology (General) ,Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice::Mice, Inbred Strains::Mice, Inbred BALB C [Medical Subject Headings] ,Inbred BALB C ,Mice, Inbred BALB C ,Tumor ,cancer cells ,endothelial cells ,macrophages ,metastasis ,pericytes ,resistance ,single-cell RNA sequencing ,tumor angiogenesis ,tumor vessel co-option ,Animals ,Cell Line, Tumor ,Endothelial Cells ,Female ,Kidney Neoplasms ,Macrophages ,Pericytes ,Single-Cell Analysis ,Diseases::Neoplasms [Medical Subject Headings] ,3. Good health ,Metástasis de la neoplasia ,Pericitos ,Anatomy::Cells::Pericytes [Medical Subject Headings] ,Cell type ,QH301-705.5 ,Anatomy::Cells::Myeloid Cells [Medical Subject Headings] ,Biology ,Diseases::Neoplasms::Neoplasms by Site::Thoracic Neoplasms::Respiratory Tract Neoplasms::Lung Neoplasms [Medical Subject Headings] ,General Biochemistry, Genetics and Molecular Biology ,Cell Line ,03 medical and health sciences ,medicine ,Macrófagos ,Inductores de la angiogénesis ,Células endoteliales ,Cancer ,medicine.disease ,030104 developmental biology ,Cancer cell ,Cancer research ,Human medicine ,030217 neurology & neurosurgery - Abstract
Tumor vessel co-option is poorly understood, yet it is a resistance mechanism against anti-angiogenic therapy (AAT). The heterogeneity of co-opted endothelial cells (ECs) and pericytes, co-opting cancer and myeloid cells in tumors growing via vessel co-option, has not been investigated at the single-cell level. Here, we use a murine AAT-resistant lung tumor model, in which VEGF-targeting induces vessel co-option for continued growth. Single-cell RNA sequencing (scRNA-seq) of 31,964 cells reveals, unexpectedly, a largely similar transcriptome of co-opted tumor ECs (TECs) and pericytes as their healthy counterparts. Notably, we identify cell types that might contribute to vessel co-option, i.e., an invasive cancer-cell subtype, possibly assisted by a matrix-remodeling macrophage population, and another M1-like macrophage subtype, possibly involved in keeping or rendering vascular cells quiescent. ispartof: CELL REPORTS vol:35 issue:11 ispartof: location:United States status: published
- Published
- 2021
- Full Text
- View/download PDF
8. De sociale lift blijft steken
- Author
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Jacobs, Dirk, Rea, Andrea, Teney, Céline, Callier, Louise, Lothaire, Sandrine, and Koning Boudewijnstichting
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Schulbildung ,school ,Immigration ,Education ,educational opportunity ,ddc:370 ,Belgium ,soziale Mobilität ,empirisch-quantitativ ,social mobility ,Bildung und Erziehung ,Migration, Sociology of Migration ,Social sciences, sociology, anthropology ,Migration ,quantitative empirical ,Sozialwissenschaften, Soziologie ,Schule ,Belgien ,school success ,empirisch ,PISA-Studie ,Macroanalysis of the Education System, Economics of Education, Educational Policy ,Segregation ,Migrant ,Makroebene des Bildungswesens ,education system ,Bildungswesen ,PISA study ,ddc:300 ,school education ,Bildungschance ,empirical ,Bildung ,Schulerfolg - Abstract
Analyse der Gründe der schlechteren schulischen Leistungen von Schülern ausländischer Herkunft. Analyse der PISA-Studie 2006: ungleiche Bildungschancen, Segregation im Bildungswesen, Notwendigkeit von mehr Demokratisierung der Schulen und von mehr sozialer Mobilität. Analysis of the reasons why pupils of migrant origin are less successful at school. Analysis of the 2006 PISA research: inequal opportunities, segregation in education, need for ongoing democratization of schools and for more social mobility.
- Published
- 2009
9. Prestaties van de leerlingen van buitenlandse herkomst in België volgens de PISA-studie: vergelijking tussen de Franse Gemeenschap en de Vlaamse Gemeenschap
- Author
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Jacobs, Dirk, Rea, Andrea, Hanquinet, Laurie, and Koning Boudewijnstichting
- Subjects
education ,Sozialwissenschaften, Soziologie ,Belgien ,school success ,empirisch ,PISA-Studie ,Migrant ,pupil ,school system ,Sociology & anthropology ,Sociology of Education ,Belgium ,Soziologie, Anthropologie ,Schulwesen ,Bildungs- und Erziehungssoziologie ,PISA study ,ddc:300 ,Schüler ,ddc:301 ,empirical ,Migration, Sociology of Migration ,Bildung ,Schulerfolg ,Social sciences, sociology, anthropology ,Migration - Published
- 2007
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