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25 results on '"Konishi, Hayato"'

8. Synthesis of an Ellagitannin Component, the Macaranoyl Group with a Tetra-ortho-Substituted Diaryl Ether Structure

Author

Hashimoto, Hajime, Ishimoto, Takayuki, Konishi, Hayato, Hirokane, Tsukasa, Wakamori, Shinnosuke, Ikeuchi, Kazutada, and Yamada, Hidetoshi

Abstract

Herein, a practical synthesis of the macaranoyl group contained in ellagitannins, i.e., a C-O digallate structure with a tetra-ortho-substituted diaryl ether bond, is described. The methodology involved an oxa-Michael addition/elimination reaction between a brominated ortho-quinone monoketal and a phenol with a hexahydroxydiphenoyl moiety in the presence of 18-crown-6 under dark conditions, followed by reductive aromatization. The existence of rotamers originating from the constructed ether moiety is discussed as well.

Published
2020

18. Beneficial Effects of Active Administration of Sildenafil on Clinical Course and Pharmacoeconomics in the Treatment of Persistent Pulmonary Hypertension After Pediatric Congenital Cardiac Surgery

Author

Nemoto, Shintaro, primary, Sasaki, Tomoyasu, additional, Ozawa, Hideki, additional, Fukuhara, Shinji, additional, Konishi, Hayato, additional, Motohashi, Yoshikazu, additional, Shimada, Ryo, additional, Katsumata, Takahiro, additional, Ozaki, Noriyasu, additional, Kishi, Kanta, additional, and Katayama, Hiroshi, additional

Published
2014
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22. Itone

Author

Go, Kentaro, primary, Konishi, Hayato, additional, and Matsuura, Yoshisuke, additional

Published
2008
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23. Abstract 10935: Long-Term Maturity and Extensibility of an In SituRegenerated Aortic Wall Induced by a Novel Synthetic Hybrid Knit

Author

Nemoto, Shintaro, Konishi, Hayato, Suzuki, Tatsuya, Suzuki, Akiyo, Katsumata, Takahiro, Yamaguchi, Ayuko, Hibino, Kiyoe, and Sakaue, Takeshi

Abstract

Introduction:A novel synthetic hybrid warp-knit with non-biodegradable (polyethylene terephthalate: PET) and biodegradable (poly-L-lactic acid: PLLA) yarns coated with crosslinked gelatin (OFT) has been used to induce in situ canine aortic wall regeneration. A recent pivotal clinical trial in Japan revealed the effectiveness and safety of this approach in pediatric cardiac surgery.Hypothesis:The regenerated aortic wall will show long-term extensibility with tissue maturation as the biodegradable yarns dissolve.Methods:An oval-shaped defect created in the canine descending aorta was filled with a patch using OFT or a currently used material (ePTFE or bovine pericardium). At 2 to 4 years after implantation, the patch-implanted aorta was explanted for histological examination and stretch-testing.Results:OFT induced a well-matured aortic wall characterized by a layered endothelium and an intima of aligned collagen fibers and smooth muscle. Bridging tissues containing capillaries developed across the remaining non-absorbable yarns. Material degradation indicated by calcium deposition was not apparent in the OFT-regenerated wall, but was clear in walls generated by currently used materials, in which only avascular collagen layers developed. The OFT-regenerated wall maintained physiological strength and was extensible by 80 to 200% of the starting width.Conclusions:The aortic wall regenerated over the OFT patch continued to mature without material degradation in the long term and showed favorable extensibility that could not be achieved with currently used materials. These long-term findings provide strong support for the suitability of use of OFT as a surgical material in pediatric cardiac surgery.

Published
2022
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24. [Three Surgical Cases of Quadricuspid Aortic Valve].

Author

Motohashi Y, Katsumata T, Suzuki T, Shimada R, Konishi H, Fukuhara S, Kanki S, Daimon M, Ozawa H, and Nemoto S

Subjects
Aged, Aortic Valve diagnostic imaging, Aortic Valve Insufficiency diagnostic imaging, Cardiac Catheters, Heart Valve Prosthesis Implantation, Humans, Male, Aortic Valve surgery, Aortic Valve Insufficiency surgery
Abstract

Quadricuspid aortic valve is a rare congenital disease. We experienced 3 surgical cases of quadricuspid aortic valve. Patient 1 was a 72-year-old man who was noted to have a quadricuspid aortic valve associated with aortic regurgitation and an ascending aortic aneurysm(51 mm in diameter). He underwent replacement of the aortic valve and the ascending aorta. Patient 2 was a 71-year-old man with severe aortic stenosis, regurgitation, and coronary triple vessel disease. He underwent aortic valve replacement and coronary artery bypass grafting. Preoperative echocardiography revealed no abnormalities in the number of valve leaflets, but quadricuspid aortic valve was identified during surgery. Patient 3 was a 79-year-old man with severe aortic regurgitation, who underwent aortic valve replacement. In all patients, the 4 valve cusps were approximately of the same size. Multi-detector computed tomography is useful for evaluation of valve morphology. Indication of prophylactic ascending aorta replacement in patients with aortic dilatation requires further study.

Published
2017

25. [Concomitant Operations for Thoracic Aortic Aneurysm and Myasthenia Gravis;Report of a Case].

Author

Konishi H, Katsumata T, Motohashi Y, Uchida H, Woo E, Sasaki T, Mieno S, Ozawa H, Daimon M, and Nemoto S

Subjects
Aged, Aortic Aneurysm, Thoracic diagnostic imaging, Humans, Male, Myasthenia Gravis diagnostic imaging, Tomography, X-Ray Computed, Aortic Aneurysm, Thoracic surgery, Myasthenia Gravis surgery
Abstract

A 77-year-old man, who had been under medical treatment for myasthenia gravis without thymoma, was diagnosed with aortic arch aneurysm. He underwent total aortic arch replacement and total resection of the thymus through median sternotomy. His symptoms relating to myasthenia gravis dramatically disappeared after the surgery. The serum anti-acetyl chorine receptor antibody decreased from 2.7 to 0.7 nmol/l (N<0.2) with the reduction of oral predonisolone from 12.5 to 5 mg/day at 4 years after the surgery. The concomitant operations significantly improved his quality of life.

Published
2017

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