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404 results on '"Konishi, Koji"'

9. Definitive S-1/mitomycin-C chemoradiotherapy for stage II/III anal canal squamous cell carcinoma: a phase I/II dose-finding and single-arm confirmatory study (JCOG0903)

Author

Ito, Yoshinori, Hamaguchi, Tetsuya, Takashima, Atsuo, Mizusawa, Junki, Shimada, Yasuhiro, Shiozawa, Manabu, Mizoguchi, Nobutaka, Kodaira, Takeshi, Komori, Koji, Ohue, Masayuki, Konishi, Koji, Teraishi, Fuminori, Kinouchi, Makoto, Murata, Kohei, Fujita, Fumihiko, Watanabe, Masahiko, Iinuma, Gen, Ishida, Fumio, Saida, Yoshihisa, Matsuda, Takahisa, Katayama, Hiroshi, Fukuda, Haruhiko, and Kanemitsu, Yukihide

Published
2023
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10. A phase II randomized trial of metastasis-directed therapy with alpha emitter radium-223 in men with oligometastatic castration-resistant prostate cancer (MEDAL)

Author

Yoshida, Soichiro, Takahara, Taro, Arita, Yuki, Ito, Masaya, Hayakawa, Sara, Oguchi, Tomohiko, Komai, Yoshinobu, Numao, Noboru, Yuasa, Takeshi, Inoue, Masaharu, Ushijima, Hiroki, Kudo, Shigehiro, Shimano, Yasumasa, Nakamura, Yuki, Uchida, Yusuke, Uehara, Sho, Tanaka, Hajime, Yaegashi, Hiroshi, Izumi, Kouji, Yokoyama, Minato, Matsuoka, Yoh, Yoshioka, Yasuo, Konishi, Koji, Nakanishi, Katsuyuki, Nagahara, Akira, Hirakawa, Akihiro, Koike, Ryuji, Koga, Fumitaka, Nishimura, Kazuo, Mizokami, Atsushi, Yonese, Junji, Kageyama, Yukio, Yoshimura, Ryoichi, and Fujii, Yasuhisa

Published
2023
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14. Long-Term Follow-up of a Randomized Controlled Trial on Accelerated Radiation Therapy Versus Standard Fractionated Radiation Therapy for Early Glottic Cancer (JCOG0701A3)

Author

Kodaira, Takeshi, Kagami, Yoshikazu, Machida, Ryunosuke, Shikama, Naoto, Sekino, Yuta, Ito, Yoshinori, Ishikura, Satoshi, Saito, Yoshihiro, Matsumoto, Yasuo, Konishi, Koji, Murakami, Naoya, Akimoto, Tetsuo, Fukushima, Yuuki, Toshiyasu, Takashi, Katano, Atsuto, Nagata, Yasushi, Ogawa, Hirofumi, Uno, Takashi, Hamamoto, Yasushi, Nishimura, Yasumasa, and Mizowaki, Takashi

Published
2023
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21. Safety and Feasibility of Combining On-Demand Selective Locoregional Treatment with First-Line Atezolizumab Plus Bevacizumab for Patients with Unresectable Hepatocellular Carcinoma

Author

Nakabori, Tasuku, primary, Higashi, Sena, additional, Abe, Yutaro, additional, Mukai, Kaori, additional, Ikawa, Toshiki, additional, Konishi, Koji, additional, Maeda, Noboru, additional, Nakanishi, Katsuyuki, additional, Hasegawa, Shinichiro, additional, Wada, Hiroshi, additional, and Ohkawa, Kazuyoshi, additional

Published
2024
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22. Multifraction stereotactic radiotherapy utilizing inhomogeneous dose distribution for brainstem metastases: a single-center retrospective analysis

Author

Ikawa, Toshiki, Kanayama, Naoyuki, Arita, Hideyuki, Takano, Koji, Sakai, Mio, Morimoto, Masahiro, Tanaka, Kazunori, Yoshino, Yutaro, Tamenaga, Setsuo, and Konishi, Koji

Abstract

Brainstem metastases are challenging to manage owing to the critical neurological structures involved. Although stereotactic radiotherapy (SRT) offers targeted high doses while minimizing damage to adjacent normal tissues, the optimal dose fractionation remains undefined. This study evaluated the efficacy and safety of multifraction SRT with an inhomogeneous dose distribution. This retrospective study included 31 patients who underwent 33 treatments for 35 brainstem lesions using linear accelerator-based multifraction SRT (30 Gy in five fractions, 35 Gy in five fractions or 42 Gy in 10 fractions) with an inhomogeneous dose distribution (median isodose, 51.9%). The outcomes of interest were local failure, toxicity and symptomatic failure. The median follow-up time after brainstem SRT for a lesion was 18.6 months (interquartile range, 10.0–24.3 months; range, 1.8–39.0 months). Grade 2 toxicities were observed in two lesions, and local failure occurred in three lesions. No grade 3 or higher toxicities were observed. The 1-year local and symptomatic failure rates were 8.8 and 16.7%, respectively. Toxicity was observed in two of seven treatments with a gross tumor volume (GTV) greater than 1 cc, whereas no toxicity was observed in treatments with a GTV less than 1 cc. No clear association was observed between the biologically effective dose of the maximum brainstem dose and the occurrence of toxicity. Our findings indicate that multifraction SRT with an inhomogeneous dose distribution offers a favorable balance between local control and toxicity in brainstem metastases. Larger multicenter studies are needed to validate these results and determine the optimal dose fractionation.

Published
2024
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23. Feasibility of a portable respiratory training system with a gyroscope sensor.

Author

Nitta, Yuya, Ueda, Yoshihiro, Ohira, Shingo, Isono, Masaru, Hirose, Asako, Inui, Shoki, Murata, Seiya, Minami, Hikari, Sagawa, Tomohiro, Nagayasu, Yukari, Miyazaki, Masayoshi, and Konishi, Koji

Subjects
RESPIRATORY organs, STANDARD deviations, GYROSCOPES, FIDUCIAL markers (Imaging systems), DETECTORS
Abstract

Objectives A portable respiratory training system with a gyroscope sensor (gyroscope respiratory training system [GRTS]) was developed and the feasibility of respiratory training was evaluated. Methods Simulated respiratory waveforms from a respiratory motion phantom and actual respirator waveforms from volunteers were acquired using the GRTS and Respiratory Gating for Scanners system (RGSC). Respiratory training was evaluated by comparing the stability and reproducibility of respiratory waveforms from patients undergoing expiratory breath-hold radiation therapy, with and without the GRTS. The stability and reproducibility of respiratory waveforms were assessed by root mean square error and gold marker placement-based success rate of expiratory breath-hold, respectively. Results The absolute mean difference for sinusoidal waveforms between the GRTS and RGSC was 2.0%. Among volunteers, the mean percentages of errors within ±15% of the respiratory waveforms acquired by the GRTS and RGSC were 96.1% for free breathing and 88.2% for expiratory breath-hold. The mean root mean square error and success rate of expiratory breath-hold (standard deviation) with and without the GRTS were 0.65 (0.24) and 0.88 (0.89) cm and 91.0% (6.9) and 89.1% (11.6), respectively. Conclusions Respiratory waveforms acquired by the GRTS exhibit good agreement with waveforms acquired by the RGSC. Respiratory training with the GRTS reduces inter-patient variability in respiratory waveforms, thereby improving the success of expiratory breath-hold radiation therapy. Advances in knowledge A respiratory training system with a gyroscope sensor is inexpensive and portable, making it ideal for respiratory training. This is the first report concerning clinical implementation of a respiratory training system. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Risk of thoracic soft tissue sarcoma after breast cancer radiotherapy: a population-based cohort study in Osaka, Japan.

Author

Ikawa, Toshiki, Kuwabara, Yoshihiro, Nakata, Kayo, Kanayama, Naoyuki, Morimoto, Masahiro, Miyashiro, Isao, and Konishi, Koji

Subjects
SARCOMA, BREAST, CANCER radiotherapy, BREAST cancer, CANCER diagnosis, JAPANESE people
Abstract

Postoperative radiotherapy for breast cancer reportedly increases the risk of thoracic soft tissue sarcomas, particularly angiosarcomas; however, the risk in the Japanese population remains unknown. Therefore, this study aimed to investigate the incidence of thoracic soft tissue sarcoma among patients with breast cancer in Japan and determine its association with radiotherapy. This retrospective cohort study used data from the population-based cancer registry of the Osaka Prefecture. The inclusion criteria were female sex, age 20–84 years, diagnosis of breast cancer between 1990 and 2010, no supraclavicular lymph node or distant metastasis, underwent surgery and survived for at least 1 year. The primary outcome was the occurrence of thoracic soft tissue sarcomas 1 year or later after breast cancer diagnosis. Among the 13 762 patients who received radiotherapy, 15 developed thoracic soft tissue sarcomas (nine angiosarcomas and six other sarcomas), with a median time of 7.7 years (interquartile range, 4.0–8.6 years) after breast cancer diagnosis. Among the 27 658 patients who did not receive radiotherapy, four developed thoracic soft tissue sarcomas (three angiosarcomas and one other sarcoma), with a median time of 11.6 years after diagnosis. The 10-year cumulative incidence was higher in the radiotherapy cohort than in the non-radiotherapy cohort (0.087 vs. 0.0036%, P  < 0.001). Poisson regression analysis revealed that radiotherapy increased the risk of thoracic soft tissue sarcoma (relative risk, 6.8; 95% confidence interval, 2.4–24.4). Thus, although rare, breast cancer radiotherapy is associated with an increased risk of thoracic soft tissue sarcoma in the Japanese population. [ABSTRACT FROM AUTHOR]

Published
2024
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27. Dual-energy computed tomography-based iodine concentration as a predictor of histopathological response to preoperative chemoradiotherapy for pancreatic cancer

Author

Ohira, Shingo, primary, Ikawa, Toshiki, additional, Kanayama, Naoyuki, additional, Minamitani, Masanari, additional, Kihara, Sayaka, additional, Inui, Shoki, additional, Ueda, Yoshihiro, additional, Miyazaki, Masayoshi, additional, Yamashita, Hideomi, additional, Nishio, Teiji, additional, Koizumi, Masahiko, additional, Nakagawa, Keiichi, additional, and Konishi, Koji, additional

Published
2023
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28. Impact of magnetic resonance imaging-related geometric distortion of dose distribution in fractionated stereotactic radiotherapy in patients with brain metastases

Author

Ohira, Shingo, primary, Suzuki, Yuta, additional, Washio, Hayate, additional, Yamamoto, Yuki, additional, Tateishi, Soichiro, additional, Inui, Shoki, additional, Kanayama, Naoyuki, additional, Kawamata, Minoru, additional, Miyazaki, Masayoshi, additional, Nishio, Teiji, additional, Koizumi, Masahiko, additional, Nakanishi, Katsuyuki, additional, and Konishi, Koji, additional

Published
2023
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34. Improved Patients’ Satisfaction Level of Radiation Therapy: The Effect of “Explainer Videos about Radiation Therapy”, “Treatment of Breast Cancer Patients by Female Radiation Therapists” and “Treating Male Patients While Wearing Underwear in Pelvic Radiation Therapy”

Author

Komiyama, Riho, primary, Ohira, Shingo, additional, Ueda, Hikari, additional, Masaoka, Akira, additional, Ikawa, Toshiki, additional, Taniguchi, Makoto, additional, Isono, Masaru, additional, Miyazaki, Masayoshi, additional, and Konishi, Koji, additional

Published
2023
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37. Additional file 3 of A phase II randomized trial of metastasis-directed therapy with alpha emitter radium-223 in men with oligometastatic castration-resistant prostate cancer (MEDAL)

Author

Yoshida, Soichiro, Takahara, Taro, Arita, Yuki, Ito, Masaya, Hayakawa, Sara, Oguchi, Tomohiko, Komai, Yoshinobu, Numao, Noboru, Yuasa, Takeshi, Inoue, Masaharu, Ushijima, Hiroki, Kudo, Shigehiro, Shimano, Yasumasa, Nakamura, Yuki, Uchida, Yusuke, Uehara, Sho, Tanaka, Hajime, Yaegashi, Hiroshi, Izumi, Kouji, Yokoyama, Minato, Matsuoka, Yoh, Yoshioka, Yasuo, Konishi, Koji, Nakanishi, Katsuyuki, Nagahara, Akira, Hirakawa, Akihiro, Koike, Ryuji, Koga, Fumitaka, Nishimura, Kazuo, Mizokami, Atsushi, Yonese, Junji, Kageyama, Yukio, Yoshimura, Ryoichi, and Fujii, Yasuhisa

Abstract

Additional file 3: The consent form given to participants.

Published
2023
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38. Additional file 1 of Linear accelerator-based stereotactic radiotherapy for brain metastases, including multiple and large lesions, carries a low incidence of acute toxicities: a retrospective analysis

Author

Ikawa, Toshiki, Kanayama, Naoyuki, Arita, Hideyuki, Ohira, Shingo, Takano, Koji, Hirata, Takero, Morimoto, Masahiro, Teshima, Teruki, and Konishi, Koji

Abstract

Additional file 1: Figures S1–S6. Stacked histogram and bar chart of dose fractionation, isodose, number of metastases, maximum tumor volume, total tumor volume, and primary tumor, stratified by the occurrence of immediate side effects.

Published
2023
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39. Additional file 2 of A phase II randomized trial of metastasis-directed therapy with alpha emitter radium-223 in men with oligometastatic castration-resistant prostate cancer (MEDAL)

Author

Yoshida, Soichiro, Takahara, Taro, Arita, Yuki, Ito, Masaya, Hayakawa, Sara, Oguchi, Tomohiko, Komai, Yoshinobu, Numao, Noboru, Yuasa, Takeshi, Inoue, Masaharu, Ushijima, Hiroki, Kudo, Shigehiro, Shimano, Yasumasa, Nakamura, Yuki, Uchida, Yusuke, Uehara, Sho, Tanaka, Hajime, Yaegashi, Hiroshi, Izumi, Kouji, Yokoyama, Minato, Matsuoka, Yoh, Yoshioka, Yasuo, Konishi, Koji, Nakanishi, Katsuyuki, Nagahara, Akira, Hirakawa, Akihiro, Koike, Ryuji, Koga, Fumitaka, Nishimura, Kazuo, Mizokami, Atsushi, Yonese, Junji, Kageyama, Yukio, Yoshimura, Ryoichi, and Fujii, Yasuhisa

Abstract

Additional file 2: The explanatory document translated to English (the original document is written in Japanese).

Published
2023
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40. Additional file 1 of A phase II randomized trial of metastasis-directed therapy with alpha emitter radium-223 in men with oligometastatic castration-resistant prostate cancer (MEDAL)

Author

Yoshida, Soichiro, Takahara, Taro, Arita, Yuki, Ito, Masaya, Hayakawa, Sara, Oguchi, Tomohiko, Komai, Yoshinobu, Numao, Noboru, Yuasa, Takeshi, Inoue, Masaharu, Ushijima, Hiroki, Kudo, Shigehiro, Shimano, Yasumasa, Nakamura, Yuki, Uchida, Yusuke, Uehara, Sho, Tanaka, Hajime, Yaegashi, Hiroshi, Izumi, Kouji, Yokoyama, Minato, Matsuoka, Yoh, Yoshioka, Yasuo, Konishi, Koji, Nakanishi, Katsuyuki, Nagahara, Akira, Hirakawa, Akihiro, Koike, Ryuji, Koga, Fumitaka, Nishimura, Kazuo, Mizokami, Atsushi, Yonese, Junji, Kageyama, Yukio, Yoshimura, Ryoichi, and Fujii, Yasuhisa

Abstract

Additional file 1: SPIRIT 2013 Checklist for the MEDAL trial.

Published
2023
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41. Additional file 3 of Linear accelerator-based stereotactic radiotherapy for brain metastases, including multiple and large lesions, carries a low incidence of acute toxicities: a retrospective analysis

Author

Ikawa, Toshiki, Kanayama, Naoyuki, Arita, Hideyuki, Ohira, Shingo, Takano, Koji, Hirata, Takero, Morimoto, Masahiro, Teshima, Teruki, and Konishi, Koji

Abstract

Additional file 3: Table S2. Pairwise comparisons of the incidence of immediate side effects, stratified by primary sites.

Published
2023
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44. Definitive radiotherapy consisting of external beam radiotherapy without central shielding and 3D image-guided brachytherapy for patients with cervical cancer: feasibility for Japanese patients and dose–response analyses for local control in the low-dose range

Author

Toita, Takafumi, Wada, Kentaro, Sutani, Shinya, Umezawa, Rei, Maemoto, Hitoshi, Ii, Noriko, Kawamura, Tomoko, Ikushima, Hitoshi, Takenaka, Ryosuke, Konishi, Koji, Yorozu, Atsunori, Jingu, Keiichi, Ariga, Takuro, Nomoto, Yoshihito, and Yamashita, Hideomi

Published
2023
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47. Efficacy and Safety of Endoscopic Resection Followed by Chemoradiotherapy for Superficial Esophageal Squamous Cell Carcinoma: A Retrospective Study

Author

Hamada, Kenta, Ishihara, Ryu, Yamasaki, Yasushi, Hanaoka, Noboru, Yamamoto, Sachiko, Arao, Masamichi, Suzuki, Sho, Iwatsubo, Taro, Kato, Minoru, Tonai, Yusuke, Shichijo, Satoki, Matsuura, Noriko, Nakahira, Hiroko, Kanesaka, Takashi, Akasaka, Tomofumi, Takeuchi, Yoji, Higashino, Koji, Uedo, Noriya, Iishi, Hiroyasu, Kanayama, Naoyuki, Hirata, Takero, Kawaguchi, Yoshifumi, Konishi, Koji, and Teshima, Teruki

Published
2017
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48. Dosimetric potential of knowledge‐based planning model trained with HyperArc plans for brain metastases.

Author

Sagawa, Tomohiro, Ueda, Yoshihiro, Tsuru, Haruhi, Kamima, Tatsuya, Ohira, Shingo, Tamura, Mikoto, Miyazaki, Masayoshi, Monzen, Hajime, and Konishi, Koji

Subjects
VOLUMETRIC-modulated arc therapy, STEREOTAXIC techniques, STEREOTACTIC radiotherapy, STEREOTACTIC radiosurgery, OPTIC nerve
Abstract

Objective: Dosimetric potential of knowledge‐based RapidPlan planning model trained with HyperArc plans (Model‐HA) for brain metastases has not been reported. We developed a Model‐HA and compared its performance with that of clinical volumetric modulated arc therapy (VMAT) plans. Methods: From 67 clinical stereotactic radiosurgery (SRS) HyperArc plans for brain metastases, 47 plans were used to build and train a Model‐HA. The other 20 clinical HyperArc plans were recalculated in RapidPlan system with Model‐HA. The model performance was validated with the 20 plans by comparing dosimetric parameters for normal brain tissue between clinical plans and model‐generated plans. The 20 clinical conventional VMAT‐based SRS or stereotactic radiotherapy plans (CL‐VMAT) were reoptimized with Model‐HA (RP) and HyperArc system (HA), respectively. The dosimetric parameters were compared among three plans (CL‐VMAT vs. RP vs. HA) in terms of planning target volume (PTV), normal brain excluding PTVs (Brain − PTV), brainstem, chiasm, and both optic nerves. Results: In model validation, the optimization performance of Model‐HA was comparable to that of HyperArc system. In comparison to CL‐VMAT, there were no significant differences among three plans with respect to PTV coverage (p > 0.17) and maximum dose for brainstem, chiasm, and optic nerves (p > 0.40). RP provided significantly lower V20 Gy, V12 Gy, and V4 Gy for Brain − PTV than CL‐VMAT (p < 0.01). Conclusion: The Model‐HA has the potential to significantly reduce the normal brain dose of the original VMAT plans for brain metastases. [ABSTRACT FROM AUTHOR]

Published
2023
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50. Improvement in bladder volume reproducibility using A‐mode portable ultrasound bladder scanner in moderate‐hypofractionated volumetric modulated arc therapy for prostate cancer patients

Author

Ohira, Shingo, primary, Komiyama, Riho, additional, Kanayama, Naoyuki, additional, Sakai, Kayo, additional, Hirata, Takero, additional, Yoshikata, Kento, additional, Ueda, Yoshihiro, additional, Miyazaki, Masayoshi, additional, Nakayama, Masashi, additional, Koizumi, Masahiko, additional, and Konishi, Koji, additional

Published
2022
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