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403 results on '"Kono, Masato"'

1. Radiological and histopathological features and treatment response by subtypes of interstitial pneumonia with autoimmune features: A prospective, multicentre cohort study

Author

Enomoto, Noriyuki, Yazawa, Shusuke, Mochizuka, Yasutaka, Fukada, Atsuki, Tanaka, Yuko, Naoi, Hyogo, Aono, Yuya, Inoue, Yusuke, Yasui, Hideki, Karayama, Masato, Suzuki, Yuzo, Hozumi, Hironao, Furuhashi, Kazuki, Toyoshima, Mikio, Kono, Masato, Imokawa, Shiro, Sano, Takehisa, Akamatsu, Taisuke, Koshimizu, Naoki, Yokomura, Koshi, Matsuda, Hiroyuki, Kaida, Yusuke, Shirai, Masahiro, Mori, Kazutaka, Masuda, Masafumi, Fujisawa, Tomoyuki, Inui, Naoki, Nakamura, Yutaro, Sugiura, Hiroaki, Sumikawa, Hiromitsu, Kitani, Masashi, Tabata, Kazuhiro, Ogawa, Noriyoshi, and Suda, Takafumi

Published
2024
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6. CT assessment of the normal upper-lobe lung volume in idiopathic pleuroparenchymal fibroelastosis

Author

Suzuki, Yuzo, primary, Kono, Masato, additional, Hasegawa, Hirotsugu, additional, Hashimoto, Dai, additional, Yokomura, Koshi, additional, Inoue, Yusuke, additional, Yasui, Hideki, additional, Hozumi, Hironao, additional, Karayama, Masato, additional, Furuhashi, Kazuki, additional, Enomoto, Noriyuki, additional, Fujisawa, Tomoyuki, additional, Inui, Naoki, additional, and Suda, Takafumi, additional

Published
2024
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8. An Adult Case of Idiopathic Pulmonary Hemosiderosis Associated with Pulmonary Fibrosis and Emphysematous Change

Author

Kono, Masato, primary, Oshima, Yuiko, additional, Katsumata, Megumi, additional, Hirama, Ryutaro, additional, Takeda, Kenichiro, additional, Mochizuka, Yasutaka, additional, Tsutsumi, Akari, additional, Miwa, Hideki, additional, Miki, Yoshihiro, additional, Hashimoto, Dai, additional, Otsuki, Yoshiro, additional, Suda, Takafumi, additional, and Nakamura, Hidenori, additional

Published
2024
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10. Standardized 3D-CT lung volumes for patients with acute exacerbation of rheumatoid arthritis-associated interstitial lung disease.

Author

Tanaka, Yuko, Suzuki, Yuzo, Saku, Aiko, Kono, Masato, Hashimoto, Dai, Hasegawa, Hirotsugu, Yokomura, Koshi, Inoue, Yusuke, Hozumi, Hironao, Karayama, Masato, Furuhashi, Kazuki, Enomoto, Noriyuki, Fujisawa, Tomoyuki, Inui, Naoki, and Suda, Takafumi

Subjects
DISEASE exacerbation, RISK assessment, THREE-dimensional imaging, RESEARCH funding, RHEUMATOID arthritis, INTERSTITIAL lung diseases, QUANTITATIVE research, DESCRIPTIVE statistics, MULTIVARIATE analysis, SEVERITY of illness index, LONGITUDINAL method, LUNG volume measurements, RESEARCH, DISEASE risk factors, DISEASE complications
Abstract

Objectives Fibrotic interstitial lung disease (ILD) is a progressive lung disease characterized by loss of lung volume, resulting in a leading cause of death in patients with RA. Crucially, acute exacerbation (AE) of ILD shows higher morbidity and mortality with rapid deterioration of the lungs. However, a quantitative assessment for physiological changes at AE has yet to be performed. This study hypothesized that quantitative assessments of lung volume (LV) accurately indicate disease severity and mortality risk in patients with AE-RA-ILD. Methods This multicentre cohorts study quantitatively assessed physiological changes of RA-ILD at diagnosis (n  = 54), at AE (discovery-cohorts; n  = 20, and validation-cohort; n  = 33), and controls (n  = 35) using 3D CT (3D-CT) images. LV was quantitatively measured using 3D-CT and standardized by predicted forced vital capacity. Results Patients with RA-ILD at diagnosis showed decreased LV, predominantly in lower lobes, compared with controls. Further substantial volume loss was found in upper- and lower lobes at AE compared with those at diagnosis. During AE, decreased standardized 3D-CT LV was associated with a worse prognosis in both cohorts. Subsequently, standardized 3D-CT LV was identified as a significant prognostic factor independent of age, sex and the presence of UIP pattern on CT by multivariate analyses. Notably, a composite model of age and standardized 3D-CT LV successfully classified mortality risk in patients with AE-RA-ILD. Conclusion Volume loss at AE in patients with RA-ILD was associated with increased mortality. Assessing physiological change using standardized 3D-CT might help evaluate disease severity and mortality risk in patients with AE-RA-ILD. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Neutrophil–lymphocyte ratio in patients with idiopathic pleuroparenchymal fibroelastosis

Author

Suzuki, Yuzo, primary, Kono, Masato, additional, Hasegawa, Hirotsugu, additional, Hashimoto, Dai, additional, Yokomura, Koshi, additional, Imokawa, Shiro, additional, Inoue, Yusuke, additional, Hozumi, Hironao, additional, Karayama, Masato, additional, Furuhashi, Kazuki, additional, Enomoto, Noriyuki, additional, Fujisawa, Tomoyuki, additional, Inui, Naoki, additional, and Suda, Takafumi, additional

Published
2023
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13. Association of the lung immune prognostic index with the survival of patients with idiopathic interstitial pneumonias

Author

Suzuki, Takahito, primary, Karayama, Masato, additional, Aoshima, Yoichiro, additional, Mori, Kazutaka, additional, Yoshizawa, Nobuko, additional, Ichikawa, Shintaro, additional, Kato, Shinpei, additional, Yokomura, Koshi, additional, Kono, Masato, additional, Hashimoto, Dai, additional, Inoue, Yusuke, additional, Yasui, Hideki, additional, Hozumi, Hironao, additional, Suzuki, Yuzo, additional, Furuhashi, Kazuki, additional, Fujisawa, Tomoyuki, additional, Enomoto, Noriyuki, additional, Goshima, Satoshi, additional, Inui, Naoki, additional, and Suda, Takafumi, additional

Published
2023
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16. Efficacy of immune checkpoint inhibitors in non-small cell lung cancer with uncommon histology: a propensity-score-matched analysis

Author

Miyashita, Koichi, Karayama, Masato, Inoue, Yusuke, Hozumi, Hironao, Suzuki, Yuzo, Furuhashi, Kazuki, Fujisawa, Tomoyuki, Enomoto, Noriyuki, Nakamura, Yutaro, Kono, Masato, Matsui, Takashi, Niwa, Mitsuru, Koda, Keigo, Toyoshima, Mikio, Matsushima, Sayomi, Matsuura, Shun, Asada, Kazuhiro, Fujii, Masato, Kusagaya, Hideki, Matsuda, Hiroyuki, Inui, Naoki, and Suda, Takafumi

Published
2021
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19. Prognostic impact of an early marginal decline in forced vital capacity in idiopathic pulmonary fibrosis patients treated with pirfenidone

Author

Kono, Masato, Nakamura, Yutaro, Enomoto, Noriyuki, Saito, Go, Koyanagi, Yu, Miyashita, Koichi, Tsutsumi, Akari, Kobayashi, Takeshi, Yasui, Hideki, Hozumi, Hironao, Karayama, Masato, Suzuki, Yuzo, Furuhashi, Kazuki, Miki, Yoshihiro, Hashimoto, Dai, Fujisawa, Tomoyuki, Inui, Naoki, Suda, Takafumi, and Nakamura, Hidenori

Published
2019
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22. Enantioselective Formal Synthesis of (–)-Catharanthine through Enzyme-Catalyzed Desymmetrization of a meso -Azabicyclo [2.2.2]octane.

Author

Ikeda, Kotaro, Harada, Shingo, Hashimoto, Yoshinori, Homma, Haruka, Kono, Masato, Zumbrägel, Nadine, Gröger, Harald, and Nemoto, Tetsuhiro

Subjects
AMINO ketones, CHEMICAL reactions, LIPASES, CATALYST poisoning, ORGANIC solvents, CHEMISTS, ACYLATION, COPPER catalysts
Abstract

This article explores the synthesis of (-)-Catharanthine, a compound used in the production of anticancer drugs. The authors focus on the use of enzyme catalysts in the synthesis process, highlighting the potential of biocatalysts in environmentally friendly organic syntheses. They describe a method for synthesizing a chiral isoquinuclidine using an enzyme catalyst, which could be used to produce a key intermediate for (-)-Catharanthine synthesis. The researchers successfully obtained a chiral amino alcohol with high enantioselectivity and yield, which they used to synthesize (-)-Catharanthine. Ongoing studies in the laboratory aim to develop synthetic strategies for other natural products with complex chiral ring systems. [Extracted from the article]

Published
2024
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23. Association of the lung immune prognostic index with the survival of patients with idiopathic interstitial pneumonias.

Author

Suzuki, Takahito, Karayama, Masato, Aoshima, Yoichiro, Mori, Kazutaka, Yoshizawa, Nobuko, Ichikawa, Shintaro, Kato, Shinpei, Yokomura, Koshi, Kono, Masato, Hashimoto, Dai, Inoue, Yusuke, Yasui, Hideki, Hozumi, Hironao, Suzuki, Yuzo, Furuhashi, Kazuki, Fujisawa, Tomoyuki, Enomoto, Noriyuki, Goshima, Satoshi, Inui, Naoki, and Suda, Takafumi

Subjects
IDIOPATHIC interstitial pneumonias, OVERALL survival, IDIOPATHIC pulmonary fibrosis, LUNGS, NEUTROPHIL lymphocyte ratio
Abstract

Background and Objective: The lung immune prognostic index (LIPI), a simple index calculated from the blood lactate dehydrogenase level and derived neutrophil‐to‐lymphocyte ratio, is thought to be associated with host immune status. However, the utility of LIPI in patients with idiopathic interstitial pneumonias (IIPs) is unknown. Methods: In this multicentre, retrospective, observational study, an association between LIPI and the survival of patients with IIPs was evaluated. Results: Exploratory and validation cohorts consisting of 460 and 414 patients with IIPs, respectively, were included (159 and 159 patients had idiopathic pulmonary fibrosis [IPF], and 301 and 255 had non‐IPF, respectively). In the exploratory cohort, patients with IPF and a low LIPI had significantly better survival than those with a high LIPI (median of 5.6 years vs. 3.9 years, p = 0.016). The predictive ability of LIPI for the survival of patients with IPF was validated in the validation cohort (median of 8.5 years vs. 4.4 years, p = 0.003). In a multivariate Cox proportional hazard analysis, LIPI was selected as an independent predictive factor for the survival of IPF patients. There was no significant association between LIPI and survival of non‐IPF patients in the exploratory and validation cohorts. Conclusion: The LIPI was a predictive factor for the survival of patients with IPF and could aid the management of IPF. [ABSTRACT FROM AUTHOR]

Published
2024
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25. Distinctive characteristics and prognostic significance of interstitial pneumonia with autoimmune features in patients with chronic fibrosing interstitial pneumonia

Author

Yoshimura, Katsuhiro, Kono, Masato, Enomoto, Yasunori, Nishimoto, Koji, Oyama, Yoshiyuki, Yasui, Hideki, Hozumi, Hironao, Karayama, Masato, Suzuki, Yuzo, Furuhashi, Kazuki, Enomoto, Noriyuki, Fujisawa, Tomoyuki, Nakamura, Yutaro, Inui, Naoki, Sumikawa, Hiromitsu, Johkoh, Takeshi, Colby, Thomas V., Sugimura, Haruhiko, and Suda, Takafumi

Published
2018
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26. Geriatric Nutritional Risk Index is a predictor of tolerability of antifibrotic therapy and mortality risk in patients with idiopathic pulmonary fibrosis

Author

Mochizuka, Yasutaka, primary, Suzuki, Yuzo, additional, Kono, Masato, additional, Hasegawa, Hirotsugu, additional, Hashimoto, Dai, additional, Yokomura, Koshi, additional, Inoue, Yusuke, additional, Yasui, Hideki, additional, Hozumi, Hironao, additional, Karayama, Masato, additional, Furuhashi, Kazuki, additional, Enomoto, Noriyuki, additional, Fujisawa, Tomoyuki, additional, Inui, Naoki, additional, Nakamura, Hidenori, additional, and Suda, Takafumi, additional

Published
2023
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29. Evaluation of urinary desmosines as a noninvasive diagnostic biomarker in patients with idiopathic pleuroparenchymal fibroelastosis (PPFE)

Author

Oyama, Yoshiyuki, Enomoto, Noriyuki, Suzuki, Yuzo, Kono, Masato, Fujisawa, Tomoyuki, Inui, Naoki, Nakamura, Yutaro, Kuroishi, Shigeki, Yokomura, Koshi, Toyoshima, Mikio, Imokawa, Shiro, Oishi, Keiji, Watanabe, Satoshi, Kasahara, Kazuo, Baba, Tomohisa, Ogura, Takashi, Ishii, Hiroshi, Watanabe, Kentaro, Nishioka, Yasuhiko, and Suda, Takafumi

Published
2017
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30. Enantioselective Formal Synthesis of (–)-Catharanthine through Enzyme-Catalyzed Desymmetrization of a meso-Azabicyclo [2.2.2]octane

Author

Ikeda, Kotaro, Harada, Shingo, Hashimoto, Yoshinori, Homma, Haruka, Kono, Masato, Zumbrägel, Nadine, Gröger, Harald, and Nemoto, Tetsuhiro

Subjects
enzymatic desymmetrization, desymmetrization, carbenes, synthesis, isoquinuclidines, Organic Chemistry, enantioselective, alkaloids
Abstract

Iboga-type indole alkaloids are a promising compound group of potentially effective drugs. The common indole-fused pentacyclic skeleton is composed of an isoquinuclidine, and both enantiomers of this architecture are naturally present. In this study, we used enzymatic desymmetrization to obtain an optically active isoquinuclidine possessing four chiral carbon centers from a prochiral diester in one step. In addition, we synthesized a pentacyclic intermediate for catharanthine in an enantioenriched form through the late-stage construction of the common Iboga scaffold.

Published
2023

31. Assessment of malnutrition-related risk in patients with idiopathic pleuroparenchymal fibroelastosis

Author

Suzuki, Yuzo, primary, Fukada, Atsuki, additional, Mori, Kazutaka, additional, Kono, Masato, additional, Hasegawa, Hirotsugu, additional, Hashimoto, Dai, additional, Yokomura, Koshi, additional, Imokawa, Shiro, additional, Inoue, Yusuke, additional, Yasui, Hideki, additional, Hozumi, Hironao, additional, Karayama, Masato, additional, Furuhashi, Kazuki, additional, Enomoto, Noriyuki, additional, Fujisawa, Tomoyuki, additional, Inui, Naoki, additional, Nakamura, Hidenori, additional, and Suda, Takafumi, additional

Published
2023
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32. A predictive model for acute exacerbation of idiopathic interstitial pneumonias

Author

Karayama, Masato, primary, Aoshima, Yoichiro, additional, Suzuki, Takahito, additional, Mori, Kazutaka, additional, Yoshizawa, Nobuko, additional, Ichikawa, Shintaro, additional, Kato, Shinpei, additional, Yokomura, Koshi, additional, Kono, Masato, additional, Hashimoto, Dai, additional, Inoue, Yusuke, additional, Yasui, Hideki, additional, Hozumi, Hironao, additional, Suzuki, Yuzo, additional, Furuhashi, Kazuki, additional, Fujisawa, Tomoyuki, additional, Enomoto, Noriyuki, additional, Goshima, Satoshi, additional, Inui, Naoki, additional, and Suda, Takafumi, additional

Published
2023
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33. Intra-abdominal Hemorrhage Due to Splenic Vein Aneurysm Rupture Caused by Invasive Aspergillosis during Treatment for Advanced Non-small-cell Lung Cancer

Author

Hirama, Ryutaro, primary, Kono, Masato, additional, Kobayashi, Takeshi, additional, Oshima, Yuiko, additional, Takeda, Kenichiro, additional, Miyashita, Koichi, additional, Miwa, Hideki, additional, Tsutsumi, Akari, additional, Miki, Yoshihiro, additional, Hashimoto, Dai, additional, Otsuki, Yoshiro, additional, and Nakamura, Hidenori, additional

Published
2023
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41. Assessment of malnutrition-related risk in patients with idiopathic pleuroparenchymal fibroelastosis

Author

Suzuki, Yuzo, primary, Fukada, Atsuki, additional, Mori, Kazutaka, additional, Kono, Masato, additional, Hasegawa, Hirotsugu, additional, Hashimoto, Dai, additional, Yokomura, Koshi, additional, Imokawa, Shiro, additional, Inoue, Yusuke, additional, Yasui, Hideki, additional, Hozumi, Hironao, additional, Karayama, Masato, additional, Furuhashi, Kazuki, additional, Enomoto, Noriyuki, additional, Fujisawa, Tomoyuki, additional, Inui, Naoki, additional, Nakamura, Hidenori, additional, and Suda, Takafumi, additional

Published
2022
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42. Prognostic significance of radiological pleuroparenchymal fibroelastosis inMycobacterium aviumcomplex lung disease: a multicentre retrospective cohort study

Author

Aono, Yuya, primary, Hozumi, Hironao, additional, Kono, Masato, additional, Hashimoto, Dai, additional, Nakamura, Hidenori, additional, Yokomura, Koshi, additional, Imokawa, Shiro, additional, Shirai, Masahiro, additional, Akahori, Daisuke, additional, Inoue, Yusuke, additional, Mori, Kazutaka, additional, Karayama, Masato, additional, Suzuki, Yuzo, additional, Furuhashi, Kazuki, additional, Enomoto, Noriyuki, additional, Fujisawa, Tomoyuki, additional, Nakamura, Yutaro, additional, Inui, Naoki, additional, and Suda, Takafumi, additional

Published
2022
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43. Clinical Significance of Forced Oscillation Technique for Evaluation of Small Airway Disease in Interstitial Lung Diseases

Author

Mikamo, Masashi, Fujisawa, Tomoyuki, Oyama, Yoshiyuki, Kono, Masato, Enomoto, Noriyuki, Nakamura, Yutaro, Inui, Naoki, Sumikawa, Hiromitsu, Johkoh, Takeshi, and Suda, Takafumi

Subjects
Interstitial lung diseases -- Diagnosis -- Care and treatment -- Research, CAT scans -- Usage -- Research, Health
Abstract

Purpose Small airway disease (SAWD) in patients with interstitial lung disease (ILD) is often assessed by high-resolution computed tomography (HRCT). However, frequent HRCT examinations result in a high level of radiographic exposure. This study investigated the utility of the forced oscillation technique (FOT) to evaluate SAWD in patients with ILD. Methods Broadband FOT using a commercially available device (MostGraph-01) and pulmonary function tests (PFT) were performed in 90 patients with ILD. HRCT images taken within 3 months were reviewed. The patients were divided into two groups according to the presence or absence of SAWD findings detected by HRCT. Clinical characteristics, PFT, and FOT between the two groups were compared. Results Of the 90 patients with ILD, 19 were classified as having SAWD findings (the presence group) and 71 as not having SAWD findings (the absence group). There were no significant differences in parameters of PFT between the two groups. The presence group had higher absolute values of reactance at 5 Hz (X5), resonant frequency (Fres), and low-frequency reactance area (ALX) than did the absence group. A within-breath change analysis demonstrated that the change in X5, Fres, and ALX between expiration and inspiration ([DELTA]X5, [DELTA]Fres, [DELTA]ALX, respectively) was significantly different between the groups. A univariate analysis revealed that X5, Fres, ALX, [DELTA]X5, [DELTA]Fres, [DELTA]ALX were significantly associated with the presence of SAWD findings. Multivariate analysis validated that Fres was related to the presence of SAWD findings. Conclusions The FOT may be useful in detecting and evaluating SAWD in patients with ILD. Trial registration: UMIN 000020733., Author(s): Masashi Mikamo[sup.1] , Tomoyuki Fujisawa[sup.1] , Yoshiyuki Oyama[sup.1] , Masato Kono[sup.1] , Noriyuki Enomoto[sup.1] , Yutaro Nakamura[sup.1] , Naoki Inui[sup.2] , Hiromitsu Sumikawa[sup.3] , Takeshi Johkoh[sup.4] , Takafumi Suda[sup.1] [...]

Published
2016
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44. Idiopathic pleuroparenchymal fibroelastosis: three-dimensional computed tomography assessment of upper-lobe lung volume

Author

Fukada, Atsuki, primary, Suzuki, Yuzo, additional, Mori, Kazutaka, additional, Kono, Masato, additional, Hasegawa, Hirotsugu, additional, Hashimoto, Dai, additional, Yokomura, Koshi, additional, Imokawa, Shiro, additional, Tanaka, Yuko, additional, Inoue, Yusuke, additional, Hozumi, Hironao, additional, Karayama, Masato, additional, Furuhashi, Kazuki, additional, Enomoto, Noriyuki, additional, Fujisawa, Tomoyuki, additional, Nakamura, Yutaro, additional, Inui, Naoki, additional, Fujino, Yoshihisa, additional, Nakamura, Hidenori, additional, and Suda, Takafumi, additional

Published
2022
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47. Clinical implication of proteinase-3-antineutrophil cytoplasmic antibody in patients with idiopathic interstitial pneumonias

Author

Hozumi, Hironao, Enomoto, Noriyuki, Oyama, Yoshiyuki, Kono, Masato, Fujisawa, Tomoyuki, Inui, Naoki, Nakamura, Yutaro, and Suda, Takafumi

Subjects
Pneumonia -- Research -- Care and treatment -- Complications and side effects, Neutrophils -- Research -- Influence, Health
Abstract

Purpose The clinical significance of proteinase-3-antineutrophil cytoplasmic antibody (PR3-ANCA) positivity is not well established in idiopathic interstitial pneumonia (IIP) patients. We aimed to determine the clinical features of PR3-ANCA-positive IIP patients. Methods We retrospectively reviewed 377 consecutive IIP patients; of these, 360 patients had PR3-ANCA and myeloperoxidase-antineutrophil cytoplasmic antibody test results available. The clinical features of PR3-ANCA-positive IIP patients and control ANCA-negative idiopathic pulmonary fibrosis patients (ANCA-negative IPF) were compared. Results Sixteen patients (4.4 %) were PR3-ANCA-positive IIP and 94 (26 %) were ANCA-negative IPF. The median age at diagnosis (72 vs. 70 years, P = 0.17) and proportion of males (75 vs. 89 %, P = 0.12) in PR3-ANCA-positive IIP and ANCA-negative IPF patients, respectively, were not significantly different. Radiologically, the HRCT patterns of PR3-ANCA-positive IIP patients varied (UIP, n = 3, 18.8 %; possible UIP, n = 3, 18.8 %; NSIP, n = 5, 31.3 %; unclassifiable CT pattern, n = 5, 31.3 %) more than those of ANCA-negative IPF patients (UIP, n = 69, 73.4 %; possible UIP, n = 25, 26.6 %; P < 0.001). No PR3-ANCA-positive IIP patients developed ANCA-associated vasculitis. The 5-year survival rate was 50 % in PR3-ANCA-positive IIP patients and 52 % in ANCA-negative IPF patients with no significant difference (P = 0.96 by log-rank test). Conclusions The HRCT patterns of PR3-ANCA-positive IIP patients varied more than those of the IPF patients, but the clinical features of high IIP-onset age and male predominance were similar between the groups. Furthermore, PR3-ANCA-positive IIP patients had a poor prognosis similar to that of IPF patients., Author(s): Hironao Hozumi[sup.1] [sup.2] , Noriyuki Enomoto[sup.1] , Yoshiyuki Oyama[sup.1] , Masato Kono[sup.1] , Tomoyuki Fujisawa[sup.1] , Naoki Inui[sup.3] , Yutaro Nakamura[sup.1] , Takafumi Suda[sup.1] Author Affiliations: (1) Second Division, [...]

Published
2016
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49. Cause of Mortality and Sarcopenia in Patients with Idiopathic Pulmonary Fibrosis Receiving Anti-Fibrotic Therapy

Author

Suzuki, Yuzo, Aono, Yuya, Kono, Masato, Hasegawa, Hirotsugu, Yokomura, Koushi, Naoi, Hyogo, Hozumi, Hironao, Karayama, Masato, Furuhashi, Kazuki, Enomoto, Noriyuki, Fujisawa, Tomoyuki, Nakamura, Yutaro, Inui, Naoki, Nakamura, Hidenori, and Suda, Takafumi

Subjects
Sarcopenia, Antifibrotic therapy, Skeletal muscle loss, Idiopathic pulmonary fibrosis, respiratory system, musculoskeletal system, human activities, humanities, respiratory tract diseases
Abstract

Summary at GlanceSkeletal muscle wasting (sarcopenia) without obvious weight loss is commonly found in patients with IPF receiving antifibrotic therapy. Most study patients died of chronic respiratory failure and skeletal muscle loss was associated with worse outcomes in antifibrotic therapy, suggesting that sarcopenia prevention is crucial for patients with IPF., Background and objective: Recent research has highlighted the fundamental role of sarcopenia, characterized by loss of skeletal muscle mass and strength, with a risk of poor outcomes. Anti-Fibrotic Therapy (AFT) preserves lung function by preventing the annual decline in forced vital capacity (FVC) and is associated with improved outcomes in patients with idiopathic pulmonary fibrosis (IPF). However, altered cause of death and prognostic implications of sarcopenia in patients with IPF receiving AFT remain unknown.Methods: This study comprised two cohorts of patients with IPF receiving AFT, historical cohort of IPF patients without AFT and controls. The cause of mortality was compared with a historical cohort. Sarcopenia was assessed by measuring the cross-sectional area (ESMCSA) and muscle-attenuation (ESMMA) of erector spinae muscles via computed-tomography.Results: Patients with IPF had smaller ESMCSA and lower ESMMA but similar body mass index (BMI) than controls, suggesting patients with IPF had skeletal muscle loss without any obvious body weight loss. The most common cause of mortality in patients receiving AFT was chronic respiratory failure, accounting for approximately 60%, and decreased proportions of lung cancer were found. Subsequently, low ESMCSA was an independent prognostic factor associated with worse survival rates. Furthermore, combined assessment of ESMCSA, %FVC-predicted, and BMI values provided clear prognostic distinction.Conclusion: Patients with IPF receiving AFT showed skeletal muscle loss without obvious weight loss. These patients mostly died by chronic respiratory failure, and skeletal muscle wasting has prognostic significance, suggesting that preventing sarcopenia as well as preserving lung function is important for managing these patients., 雑誌掲載タイトル：Cause of mortality and sarcopenia in patients with idiopathic pulmonary fibrosis receiving antifibrotic therapy

Published
2021

50. sj-docx-1-taj-10.1177_20406223221108395 – Supplemental material for Chemotherapy for patients with advanced lung cancer with interstitial lung disease: a prospective observational study

Author

Koda, Keigo, Enomoto, Yasunori, Aoshima, Yoichiro, Amano, Yusuke, Kato, Shinpei, Hasegawa, Hirotsugu, Matsui, Takashi, Yokomura, Koshi, Mochizuki, Eisuke, Matsuura, Shun, Koshimizu, Naoki, Morita, Meiko, Kojima, Suguru, Watanabe, Ayano, Oyama, Yoshiyuki, Ikeda, Masaki, Kusagaya, Hideki, Uto, Tomohiro, Sato, Jun, Imokawa, Shiro, Kono, Masato, Hashimoto, Dai, Kamiya, Yosuke, Toyoshima, Mikio, Asada, Kazuhiro, Morita, Masako, Mikamo, Masashi, Yasui, Hideki, Hozumi, Hironao, Karayama, Masato, Suzuki, Yuzo, Furuhashi, Kazuki, Fujisawa, Tomoyuki, Enomoto, Noriyuki, Nakamura, Yutaro, Inui, Naoki, and Suda, Takafumi

Subjects
FOS: Psychology, 110203 Respiratory Diseases, FOS: Clinical medicine, Cardiology, 170199 Psychology not elsewhere classified, 111702 Aged Health Care, FOS: Health sciences, 110319 Psychiatry (incl. Psychotherapy), 110306 Endocrinology, 110308 Geriatrics and Gerontology, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-docx-1-taj-10.1177_20406223221108395 for Chemotherapy for patients with advanced lung cancer with interstitial lung disease: a prospective observational study by Keigo Koda, Yasunori Enomoto, Yoichiro Aoshima, Yusuke Amano, Shinpei Kato, Hirotsugu Hasegawa, Takashi Matsui, Koshi Yokomura, Eisuke Mochizuki, Shun Matsuura, Naoki Koshimizu, Meiko Morita, Suguru Kojima, Ayano Watanabe, Yoshiyuki Oyama, Masaki Ikeda, Hideki Kusagaya, Tomohiro Uto, Jun Sato, Shiro Imokawa, Masato Kono, Dai Hashimoto, Yosuke Kamiya, Mikio Toyoshima, Kazuhiro Asada, Masako Morita, Masashi Mikamo, Hideki Yasui, Hironao Hozumi, Masato Karayama, Yuzo Suzuki, Kazuki Furuhashi, Tomoyuki Fujisawa, Noriyuki Enomoto, Yutaro Nakamura, Naoki Inui and Takafumi Suda in Therapeutic Advances in Chronic Disease

Published
2022
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