Search

Your search keyword '"Konov, S"' showing total 14 results
Start Over Author "Konov, S"
14 results on '"Konov, S"'

2. 2019 update of the European AIDS Clinical Society Guidelines for treatment of people living with HIV version 10.0

Author

Ryom, L, Cotter, A, De Miguel, R, Beguelin, C, Podlekareva, D, Arribas, J, Marzolini, C, Mallon, P, Rauch, A, Kirk, O, Molina, J, Guaraldi, G, Winston, A, Bhagani, S, Cinque, P, Kowalska, J, Collins, S, Battegay, M, De Miguel Buckley, R, D'Arminio Monforte, A, Bracchi, M, Dedes, N, Horban, A, Katlama, C, Latysheva, I, Lundgren, J, Mccormack, S, Mussini, C, Pozniak, A, Pulido, F, Raffi, F, Reiss, P, Stellbrink, H, Vasylyev, M, Gibbons, S, Livio, F, Behrens, G, Bower, M, Compston, J, De Wit, S, Fabbri, L, Fux, C, Gisslen, M, Martinez, E, Miro, J, Negredo, E, Poulter, N, Sebastiani, G, Berenguer, J, Boesecke, C, Bruno, R, Konov, S, Lacombe, K, Mauss, S, Mendao, L, Peters, L, Puoti, M, Rockstroh, J, Ambrosioni, J, De Castro, N, Fatkenheuer, G, Furrer, H, Oprea, C, Volny-Anne, A, Sullivan, A, Mulcahy, F, Wensing, A, Ryom L., Cotter A., De Miguel R., Beguelin C., Podlekareva D., Arribas J. R., Marzolini C., Mallon P. G. M., Rauch A., Kirk O., Molina J. M., Guaraldi G., Winston A., Bhagani S., Cinque P., Kowalska J. D., Collins S., Battegay M., De Miguel Buckley R., D'Arminio Monforte A., Bracchi M., Dedes N., Horban A., Katlama C., Latysheva I., Lundgren J. D., McCormack S., Mussini C., Pozniak A., Pulido F., Raffi F., Reiss P., Stellbrink H. -J., Vasylyev M., Gibbons S., Livio F., Behrens G., Bower M., Compston J., De Wit S., Fabbri L. M., Fux C. A., Gisslen M., Martinez E., Miro J. M., Negredo E., Poulter N., Sebastiani G., Berenguer J., Boesecke C., Bruno R., Konov S., Lacombe K., Mauss S., Mendao L., Peters L., Puoti M., Rockstroh J. K., Ambrosioni J., De Castro N., Fatkenheuer G., Furrer H., Oprea C., Volny-Anne A., Sullivan A., Mulcahy F., Wensing A., Ryom, L, Cotter, A, De Miguel, R, Beguelin, C, Podlekareva, D, Arribas, J, Marzolini, C, Mallon, P, Rauch, A, Kirk, O, Molina, J, Guaraldi, G, Winston, A, Bhagani, S, Cinque, P, Kowalska, J, Collins, S, Battegay, M, De Miguel Buckley, R, D'Arminio Monforte, A, Bracchi, M, Dedes, N, Horban, A, Katlama, C, Latysheva, I, Lundgren, J, Mccormack, S, Mussini, C, Pozniak, A, Pulido, F, Raffi, F, Reiss, P, Stellbrink, H, Vasylyev, M, Gibbons, S, Livio, F, Behrens, G, Bower, M, Compston, J, De Wit, S, Fabbri, L, Fux, C, Gisslen, M, Martinez, E, Miro, J, Negredo, E, Poulter, N, Sebastiani, G, Berenguer, J, Boesecke, C, Bruno, R, Konov, S, Lacombe, K, Mauss, S, Mendao, L, Peters, L, Puoti, M, Rockstroh, J, Ambrosioni, J, De Castro, N, Fatkenheuer, G, Furrer, H, Oprea, C, Volny-Anne, A, Sullivan, A, Mulcahy, F, Wensing, A, Ryom L., Cotter A., De Miguel R., Beguelin C., Podlekareva D., Arribas J. R., Marzolini C., Mallon P. G. M., Rauch A., Kirk O., Molina J. M., Guaraldi G., Winston A., Bhagani S., Cinque P., Kowalska J. D., Collins S., Battegay M., De Miguel Buckley R., D'Arminio Monforte A., Bracchi M., Dedes N., Horban A., Katlama C., Latysheva I., Lundgren J. D., McCormack S., Mussini C., Pozniak A., Pulido F., Raffi F., Reiss P., Stellbrink H. -J., Vasylyev M., Gibbons S., Livio F., Behrens G., Bower M., Compston J., De Wit S., Fabbri L. M., Fux C. A., Gisslen M., Martinez E., Miro J. M., Negredo E., Poulter N., Sebastiani G., Berenguer J., Boesecke C., Bruno R., Konov S., Lacombe K., Mauss S., Mendao L., Peters L., Puoti M., Rockstroh J. K., Ambrosioni J., De Castro N., Fatkenheuer G., Furrer H., Oprea C., Volny-Anne A., Sullivan A., Mulcahy F., and Wensing A.

Abstract

Background: The European AIDS Clinical Society (EACS) Guidelines cover key aspects of HIV management with major updates every two years. Guideline highlights: The 2019 Guidelines were extended with a new section focusing on drug–drug interactions and other prescribing issues in people living with HIV (PLWH). The recommendations for treatment-naïve PLWH were updated with four preferred regimens favouring unboosted integrase inhibitors. A two-drug regimen with dolutegravir and lamivudine, and a three-drug regimen including doravirine were also added to the recommended initial regimens. Lower thresholds for hypertension were expanded to all PLWH and for cardiovascular disease prevention, the 10-year predicted risk threshold for consideration of antiretroviral therapy (ART) modification was lowered from 20% to 10%. Frailty and obesity were added as new topics. It was specified to use urine albumin to creatinine ratio to screen for glomerular disease and urine protein to creatinine ratio for tubular diseases, and thresholds were streamlined with the Kidney Disease: Improving Global Outcomes (KDIGO) recommendations. Hepatitis C virus (HCV) treatment recommendations were split into preferred and alternative treatment options. The algorithm for management of recently acquired HCV infection was updated and includes recommendations for early chronic infection management. Treatment of resistant tuberculosis (TB) was streamlined with the World Health Organization (WHO) recommendations, and new tables on immune reconstitution inflammatory syndrome, on when to start ART in the presence of opportunistic infections and on TB drug dosing were included. Conclusions: The EACS Guidelines underwent major revisions of all sections in 2019. They are available in four different formats including a new interactive web-based version and are translated into Chinese, French, German, Japanese, Portuguese, Russian and Spanish.

Published
2020

10. Highlights of the 2017 European AIDS Clinical Society (EACS) Guidelines for the treatment of adult HIV-positive persons version 9.0

Author

Ryom, L, Boesecke, C, Bracchi, M, Ambrosioni, J, Pozniak, A, Arribas, J, Behrens, G, Mallon, P, Puoti, M, Rauch, A, Miro, J, Kirk, O, Marzolini, C, Lundgren, J, Battegay, M, d'Arminio Monforte, A, Clumeck, N, Dedes, N, Gatell, J, Horban, A, Katlama, C, Mccormack, S, Molina, J, Mussini, C, Raffi, F, Reiss, P, Stellbrink, H, Bower, M, Cinque, P, Collins, S, Compston, J, De Wit, S, Fabbri, L, Fux, C, Guaraldi, G, Martinez, E, Papapoulos, S, du Pasquier, R, Poulter, N, Williams, I, Winston, A, Berenguer, J, Bhagani, S, Bruno, R, Konov, S, Lacombe, K, Mauss, S, Mendao, L, Peters, L, Rockstroh, J, Fatkenheuer, G, Furrer, H, Mocroft, A, Morlat, P, Volny-Anne, A, Ryom L., Boesecke C., Bracchi M., Ambrosioni J., Pozniak A., Arribas J., Behrens G., Mallon P. G. M., Puoti M., Rauch A., Miro J. M., Kirk O., Marzolini C., Lundgren J. D., Battegay M., d'Arminio Monforte A., Clumeck N., Dedes N., Gatell J. M., Horban A., Katlama C., McCormack S., Molina J. -M., Mussini C., Raffi F., Reiss P., Stellbrink H. -J., Bower M., Cinque P., Collins S., Compston J., De Wit S., Fabbri L. M., Fux C. A., Guaraldi G., Martinez E., Papapoulos S., du Pasquier R., Poulter N., Williams I., Winston A., Berenguer J., Bhagani S., Bruno R., Konov S., Lacombe K., Mauss S., Mendao L., Peters L., Rockstroh J. K., Fatkenheuer G., Furrer H., Mocroft A., Morlat P., Volny-Anne A., Ryom, L, Boesecke, C, Bracchi, M, Ambrosioni, J, Pozniak, A, Arribas, J, Behrens, G, Mallon, P, Puoti, M, Rauch, A, Miro, J, Kirk, O, Marzolini, C, Lundgren, J, Battegay, M, d'Arminio Monforte, A, Clumeck, N, Dedes, N, Gatell, J, Horban, A, Katlama, C, Mccormack, S, Molina, J, Mussini, C, Raffi, F, Reiss, P, Stellbrink, H, Bower, M, Cinque, P, Collins, S, Compston, J, De Wit, S, Fabbri, L, Fux, C, Guaraldi, G, Martinez, E, Papapoulos, S, du Pasquier, R, Poulter, N, Williams, I, Winston, A, Berenguer, J, Bhagani, S, Bruno, R, Konov, S, Lacombe, K, Mauss, S, Mendao, L, Peters, L, Rockstroh, J, Fatkenheuer, G, Furrer, H, Mocroft, A, Morlat, P, Volny-Anne, A, Ryom L., Boesecke C., Bracchi M., Ambrosioni J., Pozniak A., Arribas J., Behrens G., Mallon P. G. M., Puoti M., Rauch A., Miro J. M., Kirk O., Marzolini C., Lundgren J. D., Battegay M., d'Arminio Monforte A., Clumeck N., Dedes N., Gatell J. M., Horban A., Katlama C., McCormack S., Molina J. -M., Mussini C., Raffi F., Reiss P., Stellbrink H. -J., Bower M., Cinque P., Collins S., Compston J., De Wit S., Fabbri L. M., Fux C. A., Guaraldi G., Martinez E., Papapoulos S., du Pasquier R., Poulter N., Williams I., Winston A., Berenguer J., Bhagani S., Bruno R., Konov S., Lacombe K., Mauss S., Mendao L., Peters L., Rockstroh J. K., Fatkenheuer G., Furrer H., Mocroft A., Morlat P., and Volny-Anne A.

Abstract

Background: The European AIDS Clinical Society (EACS) Guidelines have since 2005 provided multidisciplinary recommendations for the care of HIV-positive persons in geographically diverse areas. Guideline highlights: Major revisions have been made in all sections of the 2017 Guidelines: antiretroviral treatment (ART), comorbidities, coinfections and opportunistic diseases. Newly added are also a summary of the main changes made, and direct video links to the EACS online course on HIV Management. Recommendations on the clinical situations in which tenofovir alafenamide may be considered over tenofovir disoproxil fumarate are provided, and recommendations on which antiretrovirals can be used safely during pregnancy have been revised. Renal and bone toxicity and hepatitis C virus (HCV) treatment have been added as potential reasons for ART switches in fully virologically suppressed individuals, and dolutegravir/rilpivirine has been included as a treatment option. In contrast, dolutegravir monotherapy is not recommended. New recommendations on non-alcoholic fatty liver disease, chronic lung disease, solid organ transplantation, and prescribing in elderly are included, and human papilloma virus (HPV) vaccination recommendations have been expanded. All drug–drug interaction tables have been updated and new tables are included. Treatment options for direct-acting antivirals (DAAs) have been updated and include the latest combinations of sofosbuvir/velpatasvir/voxilaprevir and glecaprevir/pibrentasvir. Recommendations on management of DAA failure and acute HCV infection have been expanded. For treatment of tuberculosis (TB), it is underlined that intermittent treatment is contraindicated, and for resistant TB new data suggest that using a three-drug combination may be as effective as a five-drug regimen, and may reduce treatment duration from 18-24 to 6-10 months. Conclusions: Version 9.0 of the EACS Guidelines provides a holistic approach to HIV care and is translated

Published
2018

11. Highlights of the 2017 European AIDS Clinical Society (EACS) Guidelines for the treatment of adult HIV-positive persons version 9.0

Author

Ryom L., Boesecke C., Bracchi M., Ambrosioni J., Pozniak A., Arribas J., Behrens G., Mallon P. G. M., Puoti M., Rauch A., Miro J. M., Kirk O., Marzolini C., Lundgren J. D., Battegay M., d'Arminio Monforte A., Clumeck N., Dedes N., Gatell J. M., Horban A., Katlama C., McCormack S., Molina J. -M., Mussini C., Raffi F., Reiss P., Stellbrink H. -J., Bower M., Cinque P., Collins S., Compston J., De Wit S., Fabbri L. M., Fux C. A., Guaraldi G., Martinez E., Papapoulos S., du Pasquier R., Poulter N., Williams I., Winston A., Berenguer J., Bhagani S., Bruno R., Konov S., Lacombe K., Mauss S., Mendao L., Peters L., Rockstroh J. K., Fatkenheuer G., Furrer H., Mocroft A., Morlat P., Volny-Anne A., Ryom, L, Boesecke, C, Bracchi, M, Ambrosioni, J, Pozniak, A, Arribas, J, Behrens, G, Mallon, P, Puoti, M, Rauch, A, Miro, J, Kirk, O, Marzolini, C, Lundgren, J, Battegay, M, d'Arminio Monforte, A, Clumeck, N, Dedes, N, Gatell, J, Horban, A, Katlama, C, Mccormack, S, Molina, J, Mussini, C, Raffi, F, Reiss, P, Stellbrink, H, Bower, M, Cinque, P, Collins, S, Compston, J, De Wit, S, Fabbri, L, Fux, C, Guaraldi, G, Martinez, E, Papapoulos, S, du Pasquier, R, Poulter, N, Williams, I, Winston, A, Berenguer, J, Bhagani, S, Bruno, R, Konov, S, Lacombe, K, Mauss, S, Mendao, L, Peters, L, Rockstroh, J, Fatkenheuer, G, Furrer, H, Mocroft, A, Morlat, P, Volny-Anne, A, AII - Infectious diseases, APH - Aging & Later Life, Infectious diseases, Global Health, and AII - Amsterdam institute for Infection and Immunity

Subjects
0301 basic medicine, antiretroviral treatment, Male, Sofosbuvir, HIV Infections, chemistry.chemical_compound, 0302 clinical medicine, Pregnancy, Antiretroviral Therapy, Highly Active, HBV, Pharmacology (medical), Drug Interactions, 030212 general & internal medicine, Pregnancy Complications, Infectious, 610 Medicine & health, Coinfection, Health Policy, EACS Governing Board, Pibrentasvir, Europe, Infectious Diseases, coinfections, Anti-Retroviral Agents, Dolutegravir, HCV, Practice Guidelines as Topic, Female, ART, European AIDS Clinical Society (EACS) Guideline, medicine.drug, Adult, Societies, Scientific, medicine.medical_specialty, comorbiditie, comorbidities, European AIDS Clinical Society guidelines, HIV, opportunistic diseases, AIDS-Related Opportunistic Infections, Humans, Voxilaprevir, 030106 microbiology, Tenofovir alafenamide, 03 medical and health sciences, Acquired immunodeficiency syndrome (AIDS), Virology, medicine, opportunistic disease, Intensive care medicine, business.industry, 1103 Clinical Sciences, Glecaprevir, medicine.disease, Transplantation, European AIDS Clinical Society guideline, chemistry, business, human activities
Abstract

BACKGROUND The European AIDS Clinical Society (EACS) Guidelines have since 2005 provided multidisciplinary recommendations for the care of HIV-positive persons in geographically diverse areas. GUIDELINE HIGHLIGHTS Major revisions have been made in all sections of the 2017 Guidelines: antiretroviral treatment (ART), comorbidities, coinfections and opportunistic diseases. Newly added are also a summary of the main changes made, and direct video links to the EACS online course on HIV Management. Recommendations on the clinical situations in which tenofovir alafenamide may be considered over tenofovir disoproxil fumarate are provided, and recommendations on which antiretrovirals can be used safely during pregnancy have been revised. Renal and bone toxicity and hepatitis C virus (HCV) treatment have been added as potential reasons for ART switches in fully virologically suppressed individuals, and dolutegravir/rilpivirine has been included as a treatment option. In contrast, dolutegravir monotherapy is not recommended. New recommendations on non-alcoholic fatty liver disease, chronic lung disease, solid organ transplantation, and prescribing in elderly are included, and human papilloma virus (HPV) vaccination recommendations have been expanded. All drug-drug interaction tables have been updated and new tables are included. Treatment options for direct-acting antivirals (DAAs) have been updated and include the latest combinations of sofosbuvir/velpatasvir/voxilaprevir and glecaprevir/pibrentasvir. Recommendations on management of DAA failure and acute HCV infection have been expanded. For treatment of tuberculosis (TB), it is underlined that intermittent treatment is contraindicated, and for resistant TB new data suggest that using a three-drug combination may be as effective as a five-drug regimen, and may reduce treatment duration from 18-24 to 6-10 months. CONCLUSIONS Version 9.0 of the EACS Guidelines provides a holistic approach to HIV care and is translated into the six most commonly spoken languages.

Published
2018

12. Essentials from the 2015 European AIDS Clinical Society (EACS) guidelines for the treatment of adult HIV-positive persons

Author

Ryom, L, Boesecke, C, Gisler, V, Manzardo, C, Rockstroh, J, Puoti, M, Furrer, H, Miro, J, Gatell, J, Pozniak, A, Behrens, G, Battegay, M, Lundgren, J, Monforte, A, Arribas, J, Clumeck, N, Dedes, N, Geretti, A, Horban, A, Katlama, C, Mccormack, S, Molina, J, Mussini, C, Raffi, F, Reiss, P, Stellbrink, H, Bower, M, Cinque, P, Collins, S, Compston, J, Deray, G, De Wit, S, Fux, C, Guraldi, G, Mallon, P, Martinez, E, Marzolini, C, Papapoulos, S, du Pasquier, R, Poulter, N, Williams, I, Winston, A, Bhagani, S, Bruno, R, Konov, S, Lacombe, K, Mauss, S, Mendao, L, Peters, L, Rauch, A, Tural, C, Fatkenheuer, G, Kirk, O, Mocroft, A, Morlat, P, Volny-Anne, A, Mulcahy, F, Oprea, C, Youle, M, Ryom L., Boesecke C., Gisler V., Manzardo C., Rockstroh J. K., Puoti M., Furrer H., Miro J. M., Gatell J. M., Pozniak A., Behrens G., Battegay M., Lundgren J. D., Monforte A. D., Arribas J., Clumeck N., Dedes N., Geretti A. M., Horban A., Katlama C., McCormack S., Molina J. M., Mussini C., Raffi F., Reiss P., Stellbrink H. J., Bower M., Cinque P., Collins S., Compston J., Deray G., De Wit S., Fux C. A., Guraldi G., Mallon P., Martinez E., Marzolini C., Papapoulos S., du Pasquier R., Poulter N., Williams I., Winston A., Bhagani S., Bruno R., Konov S., Lacombe K., Mauss S., Mendao L., Peters L., Rauch A., Tural C., Fatkenheuer G., Kirk O., Mocroft A., Morlat P., Volny-Anne A., Mulcahy F., Oprea C., Youle M., Ryom, L, Boesecke, C, Gisler, V, Manzardo, C, Rockstroh, J, Puoti, M, Furrer, H, Miro, J, Gatell, J, Pozniak, A, Behrens, G, Battegay, M, Lundgren, J, Monforte, A, Arribas, J, Clumeck, N, Dedes, N, Geretti, A, Horban, A, Katlama, C, Mccormack, S, Molina, J, Mussini, C, Raffi, F, Reiss, P, Stellbrink, H, Bower, M, Cinque, P, Collins, S, Compston, J, Deray, G, De Wit, S, Fux, C, Guraldi, G, Mallon, P, Martinez, E, Marzolini, C, Papapoulos, S, du Pasquier, R, Poulter, N, Williams, I, Winston, A, Bhagani, S, Bruno, R, Konov, S, Lacombe, K, Mauss, S, Mendao, L, Peters, L, Rauch, A, Tural, C, Fatkenheuer, G, Kirk, O, Mocroft, A, Morlat, P, Volny-Anne, A, Mulcahy, F, Oprea, C, Youle, M, Ryom L., Boesecke C., Gisler V., Manzardo C., Rockstroh J. K., Puoti M., Furrer H., Miro J. M., Gatell J. M., Pozniak A., Behrens G., Battegay M., Lundgren J. D., Monforte A. D., Arribas J., Clumeck N., Dedes N., Geretti A. M., Horban A., Katlama C., McCormack S., Molina J. M., Mussini C., Raffi F., Reiss P., Stellbrink H. J., Bower M., Cinque P., Collins S., Compston J., Deray G., De Wit S., Fux C. A., Guraldi G., Mallon P., Martinez E., Marzolini C., Papapoulos S., du Pasquier R., Poulter N., Williams I., Winston A., Bhagani S., Bruno R., Konov S., Lacombe K., Mauss S., Mendao L., Peters L., Rauch A., Tural C., Fatkenheuer G., Kirk O., Mocroft A., Morlat P., Volny-Anne A., Mulcahy F., Oprea C., and Youle M.

Abstract

Background: The European AIDS Clinical Society (EACS) guidelines are intended for all clinicians involved in the care of HIV-positive persons, and are available in print, online, and as a free App for download for iPhone and Android. Guideline highlights: The 2015 version of the EACS guidelines contains major revisions in all sections; antiretroviral treatment (ART), comorbidities, coinfections and opportunistic diseases. Among the key revisions is the recommendation of ART for all HIV-positive persons, irrespectively of CD4 count, based on the Strategic Timing of AntiRetroviral Treatment (START) study results. The recommendations for the preferred and the alternative ART options have also been revised, and a new section on the use of pre-exposure prophylaxis (PrEP) has been added. A number of new antiretroviral drugs/drug combinations have been added to the updated tables on drug-drug interactions, adverse drug effects, dose adjustment for renal/liver insufficiency and for ART administration in persons with swallowing difficulties. The revisions of the coinfection section reflect the major advances in anti-hepatitis C virus (HCV) treatment with direct-acting antivirals with earlier start of treatment in individuals at increased risk of liver disease progression, and a phasing out of interferon-containing treatment regimens. The section on opportunistic diseases has been restructured according to individual pathogens/diseases and a new overview table has been added on CD4 count thresholds for different primary prophylaxes. Conclusions: The diagnosis and management of HIV infection and related coinfections, opportunistic diseases and comorbidities continue to require a multidisciplinary effort for which the 2015 version of the EACS guidelines provides an easily accessable and updated overview.

Published
2016

13. Essentials from the 2015 European AIDS Clinical Society (EACS) guidelines for the treatment of adult HIV-positive persons

Author

Ryom, L., Boesecke, C., Gisler, V., Manzardo, C., Rockstroh, J. K., Puoti, M., Furrer, H., Miro, J. M., Gatell, J. M., Pozniak, A., Behrens, G., Battegay, M., Lundgren, J. D., Monforte, A. D., Arribas, J., Clumeck, N., Dedes, N., Geretti, A. M., Horban, A., Katlama, C., Mccormack, S., Molina, J. M., Mussini, C., Raffi, F., Reiss, P., Stellbrink, H. J., Bower, M., Cinque, P., Collins, S., Compston, J., Deray, G., De Wit, S., Fux, C. A., Guraldi, G., Mallon, P., Martinez, E., Marzolini, C., Papapoulos, S., du Pasquier, R., Poulter, N., Williams, I., Winston, A., Bhagani, S., Bruno, R., Konov, S., Lacombe, K., Mauss, S., Mendao, L., Peters, L., Rauch, A., Tural, C., Fatkenheuer, G., Kirk, O., Mocroft, A., Morlat, P., Volny-Anne, A., Mulcahy, F., Oprea, C., Youle, M., Universitat de Barcelona, AII - Amsterdam institute for Infection and Immunity, APH - Amsterdam Public Health, and Global Health

Subjects
0301 basic medicine, Male, Pathology, medicine.medical_treatment, HIV Infections, Comorbidity, Pre-exposure prophylaxis, 0302 clinical medicine, Immune Reconstitution Inflammatory Syndrome, Pregnancy, Antiretroviral Therapy, Highly Active, Pharmacology (medical), Drug Interactions, 030212 general & internal medicine, Pregnancy Complications, Infectious, 610 Medicine & health, Societies, Medical, Health Policy, Antiretrovirals, Standard of Care, Viral Load, Europe, Infectious Diseases, Coinfection, Female, Post-Exposure Prophylaxis, Adult, medicine.medical_specialty, AIDS-Related Opportunistic Infections, 030106 microbiology, Guidelines as Topic, Antiretroviral treatment, ART, Comorbidities, EACS, Guidelines, HBV, HCV, HIV, Opportunistic infections, CD4 Lymphocyte Count, Humans, Pre-Exposure Prophylaxis, 03 medical and health sciences, Acquired immunodeficiency syndrome (AIDS), Immune reconstitution inflammatory syndrome, Comorbiditat, medicine, VIH (Virus), Post-exposure prophylaxis, Intensive care medicine, business.industry, HIV (Viruses), Guideline, medicine.disease, Antiretroviral agents, HIV-positive persons, business, Persones seropositives
Abstract

BACKGROUND The European AIDS Clinical Society (EACS) guidelines are intended for all clinicians involved in the care of HIV-positive persons, and are available in print, online, and as a free App for download for iPhone and Android. GUIDELINE HIGHLIGHTS The 2015 version of the EACS guidelines contains major revisions in all sections; antiretroviral treatment (ART), comorbidities, coinfections and opportunistic diseases. Among the key revisions is the recommendation of ART for all HIV-positive persons, irrespectively of CD4 count, based on the Strategic Timing of AntiRetroviral Treatment (START) study results. The recommendations for the preferred and the alternative ART options have also been revised, and a new section on the use of pre-exposure prophylaxis (PrEP) has been added. A number of new antiretroviral drugs/drug combinations have been added to the updated tables on drug-drug interactions, adverse drug effects, dose adjustment for renal/liver insufficiency and for ART administration in persons with swallowing difficulties. The revisions of the coinfection section reflect the major advances in anti-hepatitis C virus (HCV) treatment with direct-acting antivirals with earlier start of treatment in individuals at increased risk of liver disease progression, and a phasing out of interferon-containing treatment regimens. The section on opportunistic diseases has been restructured according to individual pathogens/diseases and a new overview table has been added on CD4 count thresholds for different primary prophylaxes. CONCLUSIONS The diagnosis and management of HIV infection and related coinfections, opportunistic diseases and comorbidities continue to require a multidisciplinary effort for which the 2015 version of the EACS guidelines provides an easily accessable and updated overview.

Published
2015
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results