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9. Rhinovirus-induced wheeze was associated with asthma development in predisposed children.

Author

Holmdahl, Idun, Lüning, Sofia, Wärnberg Gerdin, Sabina, Asarnoj, Anna, Hoyer, Angela, Filiou, Anastasia, Sjölander, Anders, James, Anna, Borres, Magnus P., Hedlin, Gunilla, van Hage, Marianne, Söderhäll, Cilla, and Konradsen, Jon R.

Subjects
ASTHMATICS, CHILD development, WHEEZE, ASTHMA, CHILDREN'S hospitals, PEDIATRIC emergencies
Abstract

Aim: This study explored whether early- life factors, such as rhinovirus- induced wheeze and allergic sensitisation, were related to asthma at 11 years of age. Methods: We focused on 107 children aged 6-48 months, who attended the paediatric emergency department at Astrid Lindgren's Children's Hospital in Stockholm, Sweden, with acute wheeze in 2008-2012. They also attended follow- up visits at 11 years of age and were compared with 46 age-matched healthy controls. Odds ratios (OR) with 95% confidence intervals (CI) were calculated with logistic regression. Results: We found that 62.6% of the acute wheeze cases had asthma at 11 years of age. Rhinoviruses at inclusion were the only common airway viruses associated with an increased asthma risk (OR 2.4, 95% CI 1.02-5.6). Other increased risks were parental heredity for asthma and/or allergies (adjusted OR 3.4, 95% CI 1.1-9.9) and allergic sensitisation at 2 years of age (adjusted OR 3.0, 95% CI 1.02-8.7). The highest prevalence of asthma was when children had both rhinovirus- induced wheeze at inclusion and allergic sensitisation at 7 years of age. Conclusion: Our findings highlight the importance of hereditary factors and allergic sensitisation on the development of asthma and suggest that rhinoviruses are associated with asthma development in predisposed children. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Infant lung function and early skin barrier impairment in the development of asthma at age 3 years

Author

Färdig, Martin, primary, Hoyer, Angela, additional, Almqvist, Catarina, additional, Bains, Karen Eline S., additional, Carlsen, Karin C. Lødrup, additional, Gudmundsdóttir, Hrefna Katrín, additional, Granum, Berit, additional, Haugen, Guttorm Nils, additional, Hedlin, Gunilla, additional, Jonassen, Christine Monceyron, additional, Konradsen, Jon R., additional, Lie, Anine, additional, Rehbinder, Eva Maria, additional, Skjerven, Håvard O., additional, Staff, Anne Cathrine, additional, Vettukattil, Riyas, additional, Söderhäll, Cilla, additional, and Nordlund, Björn, additional

Published
2024
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14. Inflammatory related plasma proteins involved in acute preschool wheeze

Author

Holmdahl, Idun, primary, Chakraborty, Sandip, additional, Hoyer, Angela, additional, Filiou, Anastasia, additional, Asarnoj, Anna, additional, Sjölander, Anders, additional, Borres, Magnus P., additional, van Hage, Marianne, additional, Hedlin, Gunilla, additional, Konradsen, Jon R., additional, and Söderhäll, Cilla, additional

Published
2023
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15. Recombinant PreS‐fusion protein vaccine for birch pollen and apple allergy.

Author

Khaitov, Musa, Shilovskiy, Igor, Valenta, Rudolf, Weber, Milena, Korneev, Artem, Tulaeva, Inna, Gattinger, Pia, van Hage, Marianne, Hofer, Gerhard, Konradsen, Jon R., Keller, Walter, Akinfenwa, Oluwatoyin, Poroshina, Alina, Ilina, Nataliya, Fedenko, Elena, Elisyutina, Olga, Litovkina, Alla, Smolnikov, Evgenii, Nikonova, Aleksandra, and Rybalkin, Sergei

Subjects
IMMUNOGLOBULIN E, ALLERGIC rhinitis, BIRCH, MILK allergy, RECOMBINANT proteins, ESCHERICHIA coli, ALLERGIC conjunctivitis, CARRIER proteins
Abstract

Background: IgE cross‐sensitization to major birch pollen allergen Bet v 1 and pathogenesis‐related (PR10) plant food allergens is responsible for the pollen‐food allergy syndrome. Methods: We designed a recombinant protein, AB‐PreS, consisting of non‐allergenic peptides derived from the IgE‐binding sites of Bet v 1 and the cross‐reactive apple allergen, Mal d 1, fused to the PreS domain of HBV surface protein as immunological carrier. AB‐PreS was expressed in E. coli and purified by chromatography. The allergenic and inflammatory activity of AB‐PreS was tested using basophils and PBMCs from birch pollen allergic patients. The ability of antibodies induced by immunization of rabbits with AB‐PreS and birch pollen extract‐based vaccines to inhibit allergic patients IgE binding to Bet v 1 and Mal d 1 was assessed by ELISA. Results: IgE‐binding experiments and basophil activation test revealed the hypoallergenic nature of AB‐PreS. AB‐PreS induced lower T‐cell activation and inflammatory cytokine production in cultured PBMCs from allergic patients. IgG antibodies induced by five injections with AB‐PreS inhibited allergic patients' IgE binding to Bet v 1 and Mal d 1 better than did IgG induced by up to 30 injections of six licensed birch pollen allergen extract‐based vaccines. Additionally, immunization with AB‐PreS induced HBV‐specific antibodies potentially protecting from infection with HBV. Conclusion: The recombinant AB‐PreS‐based vaccine is hypoallergenic and superior over currently registered allergen extract‐based vaccines regarding the induction of blocking antibodies to Bet v 1 and Mal d 1 in animals. [ABSTRACT FROM AUTHOR]

Published
2024
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16. A systematic review and meta‐analysis on absolute eosinophil counts and the risk of asthma in preschool children with wheezing: An EAACI Task Force Report.

Author

Adamiec, Aleksander, Cieślik, Maja, Mączka, Katarzyna, Tarnoruda, Joanna, Jensen, Signe, Chawes, Bo, Bønnelykke, Klaus, Konradsen, Jon R., Söderhäll, Cilla, Makrinioti, Heidi, Camargo, Carlos A., Hasegawa, Kohei, Ambrożej, Dominika, Jartti, Tuomas, Ruszczyński, Marek, and Feleszko, Wojciech

Subjects
PRESCHOOL children, ASTHMA in children, TASK forces, WHEEZE, EOSINOPHILS
Abstract

Preschool children with wheezing disorders pose diagnostic and therapeutic challenges and consume substantial healthcare resources. Peripheral eosinophil blood count (EBC) has been proposed as a potential indicator for future asthma development. This review by the European Academy of Allergy and Clinical Immunology (EAACI) Preschool Wheeze Task Force aimed to provide systematic evidence for the association between increased EBC and the risk of future asthma, as well as to identify potential cutoff values. In February 2023, a search of PubMed, EMBASE, and Cochrane Library databases was conducted to identify studies comparing EBCs in preschool children with wheezing who continued to wheeze later in life and those who did not. Included observational studies focused on children aged <6 years with a wheezing disorder, assessment of their EBCs, and subsequent asthma status. No language or publication date restrictions were applied. Among the initial 3394 studies screened, 10 were included in the final analysis, involving 1225 patients. The data from these studies demonstrated that high EBC in preschool children with wheezing is associated with future asthma development, with odds ratios of 1.90 (95% CI: 0.45–7.98, p =.38), 2.87 (95% CI: 1.38–5.95, p <.05), and 3.38 (95% CI: 1.72–6.64, p <.05) for cutoff values in the <300, 300–449, and ≥450 cells/μL ranges, respectively. Defining a specific cutoff point for an elevated EBC lacks consistency, but children with EBC >300 cells/μL are at increased risk of asthma. However, further research is needed due to the limitations of the included studies. Future investigations are necessary to fully elucidate the discussed association. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Rhinovirus-induced preschool wheeze in combination with allergic sensitization increases the risk of asthma in early adolescence

Author

Holmdahl, Idun, primary, Lüning, Sofia, additional, Wärnberg Gerdin, Sabina, additional, Asarnoj, Anna, additional, Hoyer, Angela, additional, Filiou, Anastasia, additional, Sjölander, Anders, additional, James, Anna, additional, Borres, Magnus, additional, Hedlin, Gunilla, additional, Van Hage, Marianne, additional, Söderhäll, Cilla, additional, and Konradsen, Jon R, additional

Published
2023
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22. Allergenic Activity of Individual Cat Allergen Molecules.

Author

Trifonova, Daria, Curin, Mirela, Riabova, Ksenja, Karsonova, Antonina, Keller, Walter, Grönlund, Hans, Käck, Ulrika, Konradsen, Jon R., van Hage, Marianne, Karaulov, Alexander, and Valenta, Rudolf

Subjects
ALLERGENS, IMMUNOGLOBULIN E, RESPIRATORY allergy, CATS, MOLECULES, MOLECULAR weights
Abstract

More than 10% of the world's population suffers from an immunoglobulin E (IgE)-mediated allergy to cats which is accompanied mainly by respiratory symptoms such as rhinitis and asthma. Several cat allergen molecules have been identified, but their allergenic activity has not been investigated in depth. Purified cat allergen molecules (Fel d 1, Fel d 2, Fel d 3, Fel d 4, Fel d 6, Fel d 7 and Fel d 8) were characterized via mass spectrometry and circular dichroism spectroscopy regarding their molecular mass and fold, respectively. Cat-allergen-specific IgE levels were quantified via ImmunoCAP measurements in IgE-sensitized subjects with (n = 37) and without (n = 20) respiratory symptoms related to cat exposure. The allergenic activity of the cat allergens was investigated by loading patients' IgE onto rat basophils expressing the human FcεRI receptor and studying the ability of different allergen concentrations to induce β-hexosaminidase release. Purified and folded cat allergens with correct masses were obtained. Cat-allergen-specific IgE levels were much higher in patients with a respiratory allergy than in patients without a respiratory allergy. Fel d 1, Fel d 2, Fel d 4 and Fel d 7 bound the highest levels of specific IgE and already-induced basophil degranulation at hundred-fold-lower concentrations than the other allergens. Fel d 1, Fel d 4 and Fel d 7 were recognized by more than 65% of patients with a respiratory allergy, whereas Fel d 2 was recognized by only 30%. Therefore, in addition to the major cat allergen Fel d 1, Fel d 4 and Fel d 7 should also be considered to be important allergens for the diagnosis and specific immunotherapy of cat allergy. [ABSTRACT FROM AUTHOR]

Published
2023
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25. EAACI Molecular Allergology User's Guide 2.0

Author

Dramburg, Stephanie, primary, Hilger, Christiane, additional, Santos, Alexandra F., additional, de las Vecillas, Leticia, additional, Aalberse, Rob C., additional, Acevedo, Nathalie, additional, Aglas, Lorenz, additional, Altmann, Friedrich, additional, Arruda, Karla L., additional, Asero, Riccardo, additional, Ballmer‐Weber, Barbara, additional, Barber, Domingo, additional, Beyer, Kirsten, additional, Biedermann, Tilo, additional, Bilo, Maria Beatrice, additional, Blank, Simon, additional, Bosshard, Philipp P., additional, Breiteneder, Heimo, additional, Brough, Helen A., additional, Bublin, Merima, additional, Campbell, Dianne, additional, Caraballo, Luis, additional, Caubet, Jean Christoph, additional, Celi, Giorgio, additional, Chapman, Martin D., additional, Chruszcz, Maksymilian, additional, Custovic, Adnan, additional, Czolk, Rebecca, additional, Davies, Janet, additional, Douladiris, Nikolaos, additional, Eberlein, Bernadette, additional, Ebisawa, Motohiro, additional, Ehlers, Anna, additional, Eigenmann, Philippe, additional, Gadermaier, Gabriele, additional, Giovannini, Mattia, additional, Gomez, Francisca, additional, Grohman, Rebecca, additional, Guillet, Carole, additional, Hafner, Christine, additional, Hamilton, Robert G., additional, Hauser, Michael, additional, Hawranek, Thomas, additional, Hoffmann, Hans Jürgen, additional, Holzhauser, Thomas, additional, Iizuka, Tomona, additional, Jacquet, Alain, additional, Jakob, Thilo, additional, Janssen‐Weets, Bente, additional, Jappe, Uta, additional, Jutel, Marek, additional, Kalic, Tanja, additional, Kamath, Sandip, additional, Kespohl, Sabine, additional, Kleine‐Tebbe, Jörg, additional, Knol, Edward, additional, Knulst, André, additional, Konradsen, Jon R., additional, Korošec, Peter, additional, Kuehn, Annette, additional, Lack, Gideon, additional, Le, Thuy‐My, additional, Lopata, Andreas, additional, Luengo, Olga, additional, Mäkelä, Mika, additional, Marra, Alessandro Maria, additional, Mills, Clare, additional, Morisset, Martine, additional, Muraro, Antonella, additional, Nowak‐Wegrzyn, Anna, additional, Nugraha, Roni, additional, Ollert, Markus, additional, Palosuo, Kati, additional, Pastorello, Elide Anna, additional, Patil, Sarita Ulhas, additional, Platts‐Mills, Thomas, additional, Pomés, Anna, additional, Poncet, Pascal, additional, Potapova, Ekaterina, additional, Poulsen, Lars K., additional, Radauer, Christian, additional, Radulovic, Suzana, additional, Raulf, Monika, additional, Rougé, Pierre, additional, Sastre, Joaquin, additional, Sato, Sakura, additional, Scala, Enrico, additional, Schmid, Johannes M., additional, Schmid‐Grendelmeier, Peter, additional, Schrama, Denise, additional, Sénéchal, Hélène, additional, Traidl‐Hoffmann, Claudia, additional, Valverde‐Monge, Marcela, additional, van Hage, Marianne, additional, van Ree, Ronald, additional, Verhoeckx, Kitty, additional, Vieths, Stefan, additional, Wickman, Magnus, additional, Zakzuk, Josefina, additional, Matricardi, Paolo M., additional, and Hoffmann‐Sommergruber, Karin, additional

Published
2023
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26. Development of sensitization to peanut and storage proteins and relation to markers of airway and systemic inflammation: A 24‐year follow‐up

Author

Tedner, Sandra G., primary, Klevebro, Susanna, additional, Bergström, Anna, additional, Kull, Inger, additional, Andersson, Niklas, additional, Borres, Magnus P., additional, Ballardini, Natalia, additional, Westman, Marit, additional, Konradsen, Jon R., additional, van Hage, Marianne, additional, Nilsson, Caroline, additional, Melén, Erik, additional, and Asarnoj, Anna, additional

Published
2022
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30. Molecular Allergen-Specific IgE Recognition Profiles and Cumulative Specific IgE Levels Associated with Phenotypes of Cat Allergy

Author

Riabova, Ksenja, primary, Karsonova, Antonina V., additional, van Hage, Marianne, additional, Käck, Ulrika, additional, Konradsen, Jon R., additional, Grönlund, Hans, additional, Fomina, Daria, additional, Beltyukov, Evgeny, additional, Glazkova, Polina A., additional, Semenov, Dmitry Yu., additional, Valenta, Rudolf, additional, Karaulov, Alexander, additional, and Curin, Mirela, additional

Published
2022
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32. Development of sensitization to peanut and storage proteins and relation to markers of airway and systemic inflammation: A 24‐year follow‐up.

Author

Tedner, Sandra G., Klevebro, Susanna, Bergström, Anna, Kull, Inger, Andersson, Niklas, Borres, Magnus P., Ballardini, Natalia, Westman, Marit, Konradsen, Jon R., van Hage, Marianne, Nilsson, Caroline, Melén, Erik, and Asarnoj, Anna

Subjects
PEANUT allergy, PEANUTS, PROTEINS, IMMUNOGLOBULIN E, INFLAMMATION, COHORT analysis
Abstract

Background: Long‐time data of peanut allergy over time is sparse. We aimed to study the longitudinal development of sensitization to peanut extract and storage protein allergen molecules and associations with asthma status, airway and systemic inflammation markers. Methods: The Swedish birth cohort BAMSE followed 4089 participants with questionnaires, clinical investigations and blood sampling between 0 and 24 years. Information on (i) background factors at 2 months, (ii) peanut allergy symptoms and IgE data (ImmunoCAP) at 4, 8, 16, and 24 years, and (iii) IgE to storage proteins, lung function data including exhaled nitric oxide (FENO) as well as systemic inflammatory markers at 24 years of age were collected. Results: The prevalence of peanut extract sensitization, defined as IgE ≥ 0.35 kUA/L, was 5.4%, 8.0%, 7.5%, and 6.2% at 4, 8, 16, and 24 years of age, respectively. Between 8 and 24 years of age, (33/1565) participants developed IgE‐ab to peanut extract (median 1,4, range 0.7–2.6 kUA/L), and among those 85% were also sensitized to birch. Only six individuals developed sensitization to Ara h 2 (≥0.1 kUA/L) between 8 and 24 years of age, of whom three had an IgE‐ab level between 0.1–0.12 kUA/L. Storage protein sensitization was associated with elevated FENO, blood eosinophils and type 2 inflammation‐related systemic proteins. Conclusion: Sensitization to peanut extract after 4 years of age is mainly induced by birch cross‐sensitization and IgE to Ara h 2 rarely emerges after eight years of age. Storage protein sensitization is associated with respiratory and systemic inflammation. [ABSTRACT FROM AUTHOR]

Published
2023
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33. IL-26 in asthma and COPD

Author

Cardenas, Eduardo I., primary, Che, Karlhans Fru, additional, Konradsen, Jon R., additional, Bao, Aihua, additional, and Lindén, Anders, additional

Published
2022
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35. Development of Sensitization to Multiple Allergen Molecules from Preschool to School Age Is Related to Asthma

Author

Filiou, Anastasia, primary, Holmdahl, Idun, additional, Asarnoj, Anna, additional, van Hage, Marianne, additional, Ekenkrantz, Tina, additional, Rydell, Niclas, additional, Sjölander, Anders, additional, Stenberg-Hammar, Katarina, additional, Hedlin, Gunilla, additional, Konradsen, Jon R., additional, and Söderhäll, Cilla, additional

Published
2022
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36. Uncontrolled asthma predicts severe COVID-19: a report from the Swedish National Airway Register

Author

Karlsson Sundbaum, Johanna, primary, Konradsen, Jon R., additional, Vanfleteren, Lowie E.G.W., additional, Axelsson Fisk, Sten, additional, Pedroletti, Christophe, additional, Sjöö, Yvonne, additional, Syk, Jörgen, additional, Sterner, Therese, additional, Lindberg, Anne, additional, Tunsäter, Alf, additional, Nyberg, Fredrik, additional, Ekberg-Jansson, Ann, additional, and Stridsman, Caroline, additional

Published
2022
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38. Impaired skin barrier and allergic sensitization in early infancy

Author

Wärnberg Gerdin, Sabina, primary, Lie, Anine, additional, Asarnoj, Anna, additional, Borres, Magnus P., additional, Lødrup Carlsen, Karin C., additional, Färdig, Martin, additional, Konradsen, Jon R., additional, Monceyron Jonassen, Christine, additional, Olsson Mägi, Caroline‐Aleksi, additional, Rehbinder, Eva Maria, additional, Rudi, Knut, additional, Skjerven, Håvard Ove, additional, Staff, Anne Cathrine, additional, Söderhäll, Cilla, additional, Tedner, Sandra G., additional, van Hage, Marianne, additional, Vettukattil, Riyas, additional, and Nordlund, Björn, additional

Published
2021
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39. Transcriptome changes during peanut oral immunotherapy and omalizumab treatment

Author

Björkander, Sophia, primary, Merid, Simon Kebede, additional, Brodin, David, additional, Brandström, Josef, additional, Fagerström‐Billai, Fredrik, additional, van der Heiden, Marieke, additional, Konradsen, Jon R., additional, Kabesch, Michael, additional, van Drunen, Cornelis M., additional, Golebski, Korneliusz, additional, Maitland‐van der Zee, Anke H., additional, Potočnik, Uroš, additional, Vijverberg, Susanne J. H., additional, Nopp, Anna, additional, Nilsson, Caroline, additional, and Melén, Erik, additional

Published
2021
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40. Risk factors associated with severe COVID-19 in asthma. A report from the Swedish National Airway Register

Author

Karlsson Sundbaum, Johanna, primary, Konradsen, Jon R, additional, Vanfleteren, Lowie, additional, Axelsson Fisk, Sten, additional, Nyberg, Fredrik, additional, Pedroletti, Christophe, additional, Sjöö, Yvonne, additional, Syk, Jörgen, additional, Lindberg, Anne, additional, Tunsäter, Alf, additional, Ekberg Jansson, Ann, additional, and Stridsman, Caroline, additional

Published
2021
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41. Predictors of severe COVID-19 in COPD

Author

Stridsman, Caroline, primary, Vanfleteren, Lowie, additional, Konradsen, Jon R, additional, Fisk, Sten Axelsson, additional, Nyberg, Fredrik, additional, Pedroletti, Christophe, additional, Sjöö, Yvonne, additional, Syk, Jörgen, additional, Lindberg, Anne, additional, Tunsäter, Alf, additional, Jansson, Ann Ekberg, additional, and Sundbaum, Johanna Karlsson, additional

Published
2021
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42. Predictors of severe COVID-19 in a registry-based Swedish cohort of patients with COPD

Author

Stridsman, Caroline, primary, Vanfleteren, Lowie E.G.W., additional, Konradsen, Jon R., additional, Axelsson Fisk, Sten, additional, Pedroletti, Christophe, additional, Sjöö, Yvonne, additional, Syk, Jörgen, additional, Sterner, Therese, additional, Lindberg, Anne, additional, Tunsäter, Alf, additional, Nyberg, Fredrik, additional, Ekberg-Jansson, Ann, additional, and Karlsson Sundbaum, Johanna, additional

Published
2021
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43. Prevalence and early‐life risk factors for tree nut sensitization and allergy in young adults

Author

Bager, Jessica, primary, Tedner, Sandra G, additional, Andersson, Niklas, additional, Ballardini, Natalia, additional, Borres, Magnus P., additional, Konradsen, Jon R, additional, Nilsson, Caroline, additional, Westman, Marit, additional, Kull, Inger, additional, Bergström, Anna, additional, van Hage, Marianne, additional, Melen, Erik, additional, and Asarnoj, Anna, additional

Published
2021
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44. Microarray Technology May Reveal the Contribution of Allergen Exposure and Rhinovirus Infections as Possible Triggers for Acute Wheezing Attacks in Preschool Children

Author

Niespodziana, Katarzyna, Stenberg-Hammar, Katarina, Papadopoulos, Nikolaos G., Focke-Tejkl, Margarete, Errhalt, Peter, Konradsen, Jon R., Söderhäll, Cilla, van Hage, Marianne, Hedlin, Gunilla, and Valenta, Rudolf

Subjects
Male, preschool children, IgE sensitization, Antibodies, Viral, Microbiology, Article, Humans, Antigens, Viral, Respiratory Sounds, Picornaviridae Infections, Infant, Allergens, Immunoglobulin E, asthma, Microarray Analysis, allergy, QR1-502, respiratory tract diseases, rhinovirus, Child, Preschool, Immunoglobulin G, wheeze, allergen exposure, Female, microarray, allergen
Abstract

Allergen exposure and rhinovirus (RV) infections are common triggers of acute wheezing exacerbations in early childhood. The identification of such trigger factors is difficult but may have therapeutic implications. Increases of IgE and IgG in sera, were shown against allergens and the N-terminal portion of the VP1 proteins of RV species, respectively, several weeks after allergen exposure or RV infection. Hence, increases in VP1-specific IgG and in allergen-specific IgE may serve as biomarkers for RV infections or allergen exposure. The MeDALL-allergen chip containing comprehensive panels of allergens and the PreDicta RV chip equipped with VP1-derived peptides, representative of three genetic RV species, were used to measure allergen-specific IgE levels and RV-species-specific IgG levels in sera obtained from 120 preschool children at the time of an acute wheezing attack and convalescence. Nearly 20% of the children (22/120) showed specific IgE sensitizations to at least one of the allergen molecules on the MeDALL chip. For 87% of the children, increases in RV-specific IgG could be detected in the follow-up sera. This percentage of RV-specific IgG increases was equal in IgE-positive and -negative children. In 10% of the children, increases or de novo appearances of IgE sensitizations indicative of allergen exposure could be detected. Our results suggest that, in the majority of preschool children, RV infections trigger wheezing attacks, but, in addition, allergen exposure seems to play a role as a trigger factor. RV-induced wheezing attacks occur in IgE-sensitized and non-IgE-sensitized children, indicating that allergic sensitization is not a prerequisite for RV-induced wheeze.

Published
2021

47. Extract and molecular‐based early infant sensitization and associated factors—A PreventADALL study

Author

Tedner, Sandra G., primary, Söderhäll, Cilla, additional, Konradsen, Jon R., additional, Bains, Karen E. S., additional, Borres, Magnus P., additional, Carlsen, Kai‐Håkon, additional, Carlsen, Karin C. L., additional, Färdig, Martin, additional, Gerdin, Sabina W., additional, Gudmundsdóttir, Hrefna K., additional, Haugen, Guttorm, additional, Hedlin, Gunilla, additional, Jonassen, Christine M., additional, Kreyberg, Ina, additional, Mägi, Caroline‐Aleksi O., additional, Nordhagen, Live S., additional, Rehbinder, Eva M., additional, Rudi, Knut, additional, Skjerven, Håvard O., additional, Staff, Anne C., additional, Vettukattil, Riyas, additional, Hage, Marianne, additional, Nordlund, Björn, additional, and Asarnoj, Anna, additional

Published
2021
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48. Reply

Author

Konradsen, Jon R., van Hage, Marianne, Hedlin, Gunilla, Hilger, Christiane, Rönmark, Eva, and Platts-Mills, Tom

Published
2015
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49. Additional file 1 of High-resolution targeted bisulfite sequencing reveals blood cell type-specific DNA methylation patterns in IL13 and ORMDL3

Author

Söderhäll, Cilla, Reinius, Lovisa E., Pertteli Salmenperä, Gentile, Massimiliano, Acevedo, Nathalie, Konradsen, Jon R., Nordlund, Björn, Hedlin, Gunilla, Scheynius, Annika, Myllykangas, Samuel, and Kere, Juha

Abstract

Additional file 1: Fig. 1. Correlation scores (Pearson) of the methylation levels of common CpG sites in IL13 and ORMDL3 analyzed by bs-OS-Seq and 450k arrays for each individual in PBMCs. X-axis shows methylation levels with 450k arrays and y-axis with bs-OS-Seq. One correlation plot per individual 1–6. Line (red) of best fit was generated through linear regression.

Published
2021
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50. Urinary Leukotriene E4 and Prostaglandin D2 Metabolites Increase in Adult and Childhood Severe Asthma Characterized by Type-2 Inflammation

Author

Kolmert, Johan, Balgoma, David, Bood, Johan, Konradsen, Jon R., Ericsson, Magnus, James, Anna, Mikus, Maria, Sousa, Ana R., Riley, John H., Bates, Stewart, Bakke, Per S., Pandis, Ioannis, Caruso, Massimo, Chanez, Pascal, Fowler, Stephen J., Geiser, Thomas, Howarth, Peter, Krug, Norbert, Montuschi, Paolo, Sanak, Marek, Behndig, Annelie, Shaw, Dominick E, Knowles, Richard G., Alving, Kjell, Hedlin, Gunilla, Chung, Kian Fan, Adcock, Ian M., Sterk, Peter J., Djukanovic, Ratko, Wheelock, Craig E., and U-BIOPRED Study Group

Subjects
Pulmonary and Respiratory Medicine, lipids (amino acids, peptides, and proteins), Critical Care and Intensive Care Medicine, respiratory tract diseases
Abstract

Rationale: New approaches are needed to guide personalized treatment of asthma.Objective: To test if urinary eicosanoid metabolites can direct asthma phenotyping.Methods: Urinary metabolites of prostaglandins (PG), cysteinyl-leukotrienes (LT) and isoprostanes were quantified in the Unbiased Biomarkers for the Prediction of Respiratory Diseases Outcomes (U-BIOPRED) study including 86 adults with mild-to-moderate asthma (MMA), 411 with severe asthma (SA), and 100 healthy controls (HC). Validation was performed in 302 SA subjects followed-up after 12-18 months, and externally in 95 adolescents with asthma.Measurement and Main Results: Metabolite levels in HC were unrelated to age, BMI and sex, except for the PGE2-pathway. Eicosanoid levels were generally greater in MMA relative to HC, with further elevations in SA, except for PGE2-metabolites in males, which were the same or lower in non-smoking asthmatics as in HC. Metabolite levels were unchanged in asthmatics adherent to oral corticosteroid treatment as documented by urinary prednisolone detection, whereas SA treated with omalizumab had lower levels of LTE4 and the PGD2 metabolite 2,3-dinor-11?-PGF2?. High levels of LTE4 and PGD2-metabolites were associated with lower lung-function, and increased levels of exhaled nitric oxide and eosinophil markers in blood, sputum and urine in U-BIOPRED and in adolescents with asthma. These type-2 (T2) asthma associations were reproduced in the follow-up visit of the U-BIOPRED study, and found to be as sensitive to detect T2 inflammation as the established biomarkers. Conclusions: Monitoring of urinary eicosanoids can identify T2 asthma and introduces a new non-invasive approach for molecular phenotyping of adult and adolescent asthma.

Published
2021

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