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5. Associations of Perirenal Fat Thickness with Renal and Systemic Calcified Atherosclerosis.

Author

Koo, Bo Kyung, Denenberg, Julie O, Wright, C Michael, Criqui, Michael H, and Allison, Matthew A

Subjects
Kidney, Humans, Kidney Diseases, Prognosis, Follow-Up Studies, Middle Aged, California, Female, Male, Intra-Abdominal Fat, Atherosclerosis, Vascular Calcification, Aorta, abdominal, Obesity, Renal artery, Vascular calcification, Aorta, abdominal
Abstract

BackgroundWe investigated associations between perirenal fat thickness and atherosclerotic calcification in six different vascular beds.MethodsUsing a community-based cohort (n=3,919), perirenal fat thickness was estimated from computed tomography scans. It was classified as Q1 (the lowest quartile) to Q4 (the highest quartile) in each sex. Calcification in the carotid arteries, coronary arteries, thoracic aorta, abdominal aorta, iliac arteries, and renal arteries was evaluated.ResultsPerirenal fat thickness was associated with older age (P

Published
2020

28. Low‐quality muscle mass rather than normal‐quality muscle mass determines fibrosis progression in biopsy‐proven NAFLD.

Author

Lee, Yun Kyu, Koo, Bo Kyung, Joo, Sae Kyung, Lee, Dong Hyeon, Jang, Heejoon, Chai, Jee Won, Lee, Myoung Seok, Jang, Si Won, So, Young Ho, Park, Jeong Hwan, Chang, Mee Soo, and Kim, Won

Subjects
*MUSCLE mass, *NON-alcoholic fatty liver disease, *FIBROSIS, *PSOAS muscles, *LUMBAR vertebrae
Abstract

Summary: Background and aims: Sarcopaenia is associated with advanced nonalcoholic fatty liver disease (NAFLD). However, the impact of the muscle mass categorised by muscle quality on fibrosis progression remains unclear. Methods: A total of 292 patients with biopsy‐proven NAFLD who underwent serial vibration‐controlled transient elastography assessments at least 1 year from baseline were selected. The skeletal muscle area (SMA) was determined on abdominal computed tomography (CT) at the third lumbar vertebra level and categorised to normal‐attenuation muscle area (NAMA), low‐attenuation muscle area (LAMA) and intermuscular adipose tissue (IMAT) using a muscle quality map. These SMAs were normalised by the height squared to obtain the skeletal muscle index (SMI). Results: At baseline, as the histological fibrosis stage increased, SMINAMA decreased and SMILAMA increased (p for trend = 0.014 and p for trend <0.001, respectively), which was not significant after adjustment for age, sex and obesity. During a median follow‐up of 41 months, fibrosis progression was detected in 48 out of 292 patients, and higher SMILAMA quartiles independently increased the risk of fibrosis progression in a dose‐dependent manner (hazard ratio [HR] per quartile: 1.41; 95% confidence interval [CI], 1.04–1.91). The highest quartile of SMILAMA increased the risk of fibrosis progression by 3.25 times compared to the lowest quartile of SMILAMA (95% CI, 1.18–8.90). SMINAMA quartiles were not associated with the risk of fibrosis progression. Conclusion: Increased low‐quality muscle mass, but not decreased normal‐quality muscle mass, as assessed by a muscle quality map in CT, predicts fibrosis progression in patients with NAFLD. [ABSTRACT FROM AUTHOR]

Published
2023
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30. Metabolic dysfunction-associated fatty liver disease as a risk factor for adverse outcomes in subsequent pregnancy: a nationwide cohort study

Author

Lee, Seung Mi, primary, Cho, Geum Joon, additional, Wi, Won Young, additional, Norwitz, Errol R., additional, Koo, Bo Kyung, additional, Lee, Jeesun, additional, Jung, Young Mi, additional, Kwak, Soo Heon, additional, Park, Chan-Wook, additional, Jun, Jong Kwan, additional, Joo, Sae Kyung, additional, Oh, Min-Jeong, additional, Kim, Won, additional, and Park, Joong Shin, additional

Published
2022
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