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4. Examining the Effectiveness of the Transdiagnostic Unified Protocol for Emotional Disorders Delivered to Youth Following Hurricane Harvey

Author

Goetz, Amy R., Kennedy, Sarah M., Kook, Minjee, Guzick, Andrew G., Nwankwo, Gifty N. Amos, Hana, Lynn M., Schneider, Sophie C., Cepeda, Sandra L., Weinzimmer, Saira A., Shah, Asim A., Goodman, Wayne K., Salloum, Alison, Ehrenreich-May, Jill, and Storch, Eric A.

Abstract

Background: Hurricane Harvey struck southeast Texas in August 2017 resulting in widespread destruction and significant emotional distress. Objective: We examined the effectiveness of a transdiagnostic psychotherapeutic intervention delivered to youth with emotional disorders in a large, community health system following this hurricane. Methods: One hundred forty-nine youth aged 5 to 17 years with a history of hurricane exposure and emotional difficulties received an average of 6.4 (SD = 3.4) psychotherapy sessions using the Unified Protocols for Transdiagnostic Treatment of Emotional Disorders in Children and Adolescents. Youth-caregiver dyads completed measures of disaster exposure and impact at baseline as well as anxiety and depression at baseline and each therapy session. Symptom severity and level of functioning were rated by the clinician. Latent growth curve modeling was used to examine symptom change over time. Results: Children and adolescents began treatment with moderate levels of anxiety and depressive symptoms, symptom severity, and difficulties in daily functioning. Anxiety and depressive symptoms and symptom severity declined significantly over the treatment period. Clinician ratings of functionality evidenced significant improvement over time. Older age was correlated with more depressive symptoms at baseline and superior functioning at baseline with fewer completed treatment sessions. Conclusion: In this naturalistic, community-based effectiveness study we found significant improvement on measures of anxiety, depression, symptom severity, and daily functioning. Findings suggest that a transdiagnostic intervention may be effective for addressing a range of emotional concerns in the aftermath of a natural disaster. These results can be used to inform and refine evidence-based interventions that improve the mental health and wellbeing of disaster-exposed youth.

Published
2023
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17. Latin American Trans‐ancestry INitiative for OCD genomics (LATINO): Study protocol.

Author

Crowley, James J., Cappi, Carolina, Ochoa‐Panaifo, Marcos E., Frederick, Renee M., Kook, Minjee, Wiese, Andrew D., Rancourt, Diana, Atkinson, Elizabeth G., Giusti‐Rodriguez, Paola, Anderberg, Jacey L., Abramowitz, Jonathan S, Adorno, Victor R, Aguirre, Cinthia, Alves, Gilberto S, Alves, Gustavo S, Ancalade, NaEshia, Anderberg, Jacey L, Arellano Espinosa, Alejandro A, Arnold, Paul D, and Atkinson, Elizabeth G

Published
2024
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18. Parent-Led Cognitive Behavioral Teletherapy for Anxiety in Autistic Youth: A Randomized Trial Comparing Two Levels of Therapist Support

Author

Guzick, Andrew G., primary, Schneider, Sophie C., additional, Kook, Minjee, additional, Rose Iacono, Julia, additional, Weinzimmer, Saira A., additional, Quast, Troy, additional, Olsen, Sean M., additional, Hughes, Killian Rainey, additional, Jellinek-Russo, Emily, additional, Garcia, Amanda Perozo, additional, Candelari, Abigail, additional, Berry, Leandra N., additional, Goin-Kochel, Robin P., additional, Goodman, Wayne K., additional, and Storch, Eric A., additional

Published
2023
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19. Family Accommodation in Children and Adolescents with Misophonia

Author

Storch, Eric A., primary, Guzick, Andrew G., additional, D'Souza, Johann, additional, Clinger, Jane, additional, Ayton, Daphne, additional, Kook, Minjee, additional, Rork, Conor, additional, Smith, Eleanor E., additional, Draper, Isabel A., additional, Khalfe, Nasim, additional, Rast, Catherine E., additional, Murphy, Nicholas, additional, Lijfijjt, Marijn, additional, Goodman, Wayne K., additional, and Cervin, Matti, additional

Published
2023
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20. Psychometric properties of the revised children’s anxiety and depression scale (RCADS) for autistic youth without co-occurring intellectual disability

Author

Khalfe, Nasim, primary, Goetz, Amy R., additional, Trent, Erika S., additional, Guzick, Andrew G., additional, Smarason, Orri, additional, Kook, Minjee, additional, Olsen, Sean, additional, Ramirez, Ana C., additional, Weinzimmer, Saira A., additional, Berry, Leandra, additional, Schneider, Sophie C., additional, Goodman, Wayne K., additional, and Storch, Eric A., additional

Published
2023
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21. Latin American Trans-ancestry INitiative for OCD genomics (LATINO): Study Protocol

Author

Crowley, James J, Cappi, Carolina, Ochoa-Panaifo, Marcos E, Frederick, Renee M, Kook, Minjee, Wiese, Andrew D, Rancourt, Diana, Atkinson, Elizabeth G, Giusti-Rodriguez, Paola, Anderberg, Jacey L, Abramowitz, Jonathan S, Adorno, Victor R, Aguirre, Cinthia, Alves, Gustavo S, Alves, Gilberto S, Ancalade, NaEshia, Arellano Espinosa, Alejandro A, Arnold, Paul D, Ayton, Daphne M, Barbosa, Izabela G, Barón Castano, Laura Marcela, Barrera, Cynthia N, Belén Prieto, María, Berardo, María Celeste, Berrones, Dayan, Best, John R, Bigdeli, Tim B, Burton, Christie L, Callahan, Jennifer L, Carneiro, Maria Cecília B, Cepeda, Sandra L, Chazelle, Evelyn, Chire, Jessica M, Churruca Munoz, Macarena, Claisse Quiroz, Pamela, Cobite, Journa, Comer, Jonathan S, Costa, Daniel L, Crosbie, Jennifer, Cruz, Victor O, Dager, Guillermo, Daza, Luisa F, de la Rosa-Gómez, Anabel, del Río, Daniela, Delage, Fernanda Z, Dreher, Carolina B, Fay, Lucila, Fazio, Tomas, Ferrão, Ygor A, Ferreira, Gabriela M, Figueroa, Edith G, Fontenelle, Leonardo F, Forero, Diego A, Fragoso, Daniele TH, Gadad, Bharathi S, Garrison, Sheldon R, González, Andres, Gonzalez, Laura D, González, Marco A, Gonzalez-Barrios, Polaris, Goodman, Wayne, Guintivano, Jerry, Guttfreund, Daniel G, Guzick, Andrew G, Halvorsen, Matthew W, Hovey, Joseph D, Janssen-Aguilar, Reinhard, Jensen, Matias, Jimenez Reynolds, Alexandra Z, Juárez Lujambio, Joali Alexandra, Khalfe, Nasim, Knutsen, Madison A, Lack, Caleb, Lanzagorta, Nuria, Lima, Monicke O, Longhurst, Melanie O, Lozada Martinez, David A, Luna, Elba S, Marques, Andrea H, Martinez, Molly, Matos, Maria de Los Angeles, Maye, Caitlyn E, McGuire, Joseph F, Menezes, Gabriela, Minaya, Charlene, Miño, Tomás, Mithani, Sara M, Montes de Oca, Circe, Morales-Rivero, Alonso, Moreira-de-Oliveira, Maria E, Morris, Olivia J, Muñoz, Sandra I, Naqqash, Zainab, Núñez Bracho, Ambar A, Núñez Bracho, Belinda E, Ochoa Rojas, Maria Corina, Olavarria Castaman, Luis A, Ortega, Iliana, Patel, Darpan I, Patrick, Ainsley K, Paz y Mino, Mariel, Perales Orellana, Jose L, Perdigão Stumpf, Bárbara, Peregrina, Tamara, Pérez Duarte, Tania, Piacsek, Kelly L, Placencia, Maritza, Quarantini, Lucas C, Quarantini-Alvim, Yana, Ramos, Renato T, Ramos, Iaroslava C, Ramos, Vanessa R, Ramsey, Kesley A, Ray, Elise V, Richter, Margaret A, Riemann, Bradley C, Rivas, Juan C, Rosario, Maria C, Ruggero, Camilo J, Ruiz-Chow, Angel A, Ruiz-Velasco, Alejandra, Sampaio, Aline S, Saraiva, Leonardo C, Schachar, Russell J, Schneider, Sophie C, Schweissing, Ethan J, Seligman, Laura D, Shavitt, Roseli G, Soileau, Keaton J, Stewart, S. Evelyn, Storch, Shaina B, Strouphauer, Emily R, Timpano, Kiara R, Treviño-de la Garza, Beatriz, Vargas-Medrano, Javier, Vásquez, María I, Vidal Martinez, Guadalupe, Weinzimmer, Saira A, Yanez, Mauricio A, Zai, Gwyneth, Zapata-Restrepo, Lina M, Zappa, Luz M, Zepeda-Burgos, Raquel M, Zoghbi, Anthony W, Miguel, Euripedes C, Rodriguez, Carolyn I, Martinez Mallen, Mayra C, Moya, Pablo R, Borda, Tania, Moyano, María Beatriz, Mattheisen, Manuel, Pereira, Stacey, Lázaro-Muñoz, Gabriel, Martinez-Gonzalez, Karen G, Pato, Michele T, Nicolini, Humberto, and Storch, Eric A

Subjects
Article
Abstract

Obsessive-compulsive disorder (OCD) is a debilitating psychiatric disorder. Worldwide, its prevalence is ~2% and its etiology is mostly unknown. Identifying biological factors contributing to OCD will elucidate underlying mechanisms and might contribute to improved treatment outcomes. Genomic studies of OCD are beginning to reveal long-sought risk loci, but >95% of the cases currently in analysis are of homogenous European ancestry. If not addressed, this Eurocentric bias will result in OCD genomic findings being more accurate for individuals of European ancestry than other ancestries, thereby contributing to health disparities in potential future applications of genomics. In this study protocol paper, we describe the Latin American Trans-ancestry INitiative for OCD genomics (LATINO, www.latinostudy.org ). LATINO is a new network of investigators from across Latin America, the United States, and Canada who have begun to collect DNA and clinical data from 5,000 richly-phenotyped OCD cases of Latin American ancestry in a culturally sensitive and ethical manner. In this project, we will utilize trans-ancestry genomic analyses to accelerate the identification of OCD risk loci, fine-map putative causal variants, and improve the performance of polygenic risk scores in diverse populations. We will also capitalize on rich clinical data to examine the genetics of treatment response, biologically plausible OCD subtypes, and symptom dimensions. Additionally, LATINO will help elucidate the diversity of the clinical presentations of OCD across cultures through various trainings developed and offered in collaboration with Latin American investigators. We believe this study will advance the important goal of global mental health discovery and equity.

Published
2023

25. Acute psychiatric care for pediatric patients.

Author

Reynolds, Elizabeth K., Gorelik, Sasha, Kook, Minjee, and Kellermeyer, Kyle

Subjects
CRITICAL care medicine, HEALTH services accessibility, LENGTH of stay in hospitals, PATIENT safety, PEDIATRICS, QUALITY assurance, EVIDENCE-based medicine, PSYCHIATRIC treatment, PATIENT readmissions, ADVERSE health care events
Abstract

Higher level or acute psychiatric care for youth is intended to be active but short-term treatment focussing on crisis stabilisation, assessment, safety monitoring, and longer-term treatment planning. The focus of this article is on describing common challenges and the effort to address these challenges through new approaches to acute psychiatric care for children and adolescents. The review finds that (1) inpatient paediatric psychiatry beds are in high demand and often difficult to access, (2) there are a number of common challenges these units face including managing length of stays, readmissions, and adverse events, and (3) there are encouraging therapeutic approaches adapted for this setting. There is still much work to be done to advance the evidence-base for acute psychiatric care for youth particularly in defining and assessing an effective admission. Paediatric psychiatry patients are a vulnerable population and call for our best tools to be put to use to improve the quality and safety of care. [ABSTRACT FROM AUTHOR]

Published
2020
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27. Latin American Trans-ancestry INitiative for OCD genomics (LATINO): Study Protocol.

Author

Crowley JJ, Cappi C, Ochoa-Panaifo ME, Frederick RM, Kook M, Wiese AD, Rancourt D, Atkinson EG, Giusti-Rodriguez P, Anderberg JL, Abramowitz JS, Adorno VR, Aguirre C, Alves GS, Alves GS, Ancalade N, Espinosa AAA, Arnold PD, Ayton DM, Barbosa IG, Castano LMB, Barrera CN, Prieto MB, Berardo MC, Berrones D, Best JR, Bigdeli TB, Burton CL, Callahan JL, Carneiro MCB, Cepeda SL, Chazelle E, Chire JM, Munoz MC, Quiroz PC, Cobite J, Comer JS, Costa DL, Crosbie J, Cruz VO, Dager G, Daza LF, de la Rosa-Gómez A, Del Río D, Delage FZ, Dreher CB, Fay L, Fazio T, Ferrão YA, Ferreira GM, Figueroa EG, Fontenelle LF, Forero DA, Fragoso DT, Gadad BS, Garrison SR, González A, Gonzalez LD, González MA, Gonzalez-Barrios P, Goodman W, Guintivano J, Guttfreund DG, Guzick AG, Halvorsen MW, Hovey JD, Janssen-Aguilar R, Jensen M, Reynolds AZJ, Lujambio JAJ, Khalfe N, Knutsen MA, Lack C, Lanzagorta N, Lima MO, Longhurst MO, Martinez DAL, Luna ES, Marques AH, Martinez M, de Los Angeles Matos M, Maye CE, McGuire JF, Menezes G, Minaya C, Miño T, Mithani SM, de Oca CM, Morales-Rivero A, Moreira-de-Oliveira ME, Morris OJ, Muñoz SI, Naqqash Z, Bracho AAN, Bracho BEN, Rojas MCO, Castaman LAO, Ortega I, Patel DI, Patrick AK, Mino MPY, Orellana JLP, Stumpf BP, Peregrina T, Duarte TP, Piacsek KL, Placencia M, Quarantini LC, Quarantini-Alvim Y, Ramos RT, Ramos IC, Ramos VR, Ramsey KA, Ray EV, Richter MA, Riemann BC, Rivas JC, Rosario MC, Ruggero CJ, Ruiz-Chow AA, Ruiz-Velasco A, Sampaio AS, Saraiva LC, Schachar RJ, Schneider SC, Schweissing EJ, Seligman LD, Shavitt RG, Soileau KJ, Stewart SE, Storch SB, Strouphauer ER, Timpano KR, Treviño-de la Garza B, Vargas-Medrano J, Vásquez MI, Martinez GV, Weinzimmer SA, Yanez MA, Zai G, Zapata-Restrepo LM, Zappa LM, Zepeda-Burgos RM, Zoghbi AW, Miguel EC, Rodriguez CI, Mallen MCM, Moya PR, Borda T, Moyano MB, Mattheisen M, Pereira S, Lázaro-Muñoz G, Martinez-Gonzalez KG, Pato MT, Nicolini H, and Storch EA

Abstract

Obsessive-compulsive disorder (OCD) is a debilitating psychiatric disorder. Worldwide, its prevalence is ~2% and its etiology is mostly unknown. Identifying biological factors contributing to OCD will elucidate underlying mechanisms and might contribute to improved treatment outcomes. Genomic studies of OCD are beginning to reveal long-sought risk loci, but >95% of the cases currently in analysis are of homogenous European ancestry. If not addressed, this Eurocentric bias will result in OCD genomic findings being more accurate for individuals of European ancestry than other ancestries, thereby contributing to health disparities in potential future applications of genomics. In this study protocol paper, we describe the Latin American Trans-ancestry INitiative for OCD genomics (LATINO, www.latinostudy.org). LATINO is a new network of investigators from across Latin America, the United States, and Canada who have begun to collect DNA and clinical data from 5,000 richly-phenotyped OCD cases of Latin American ancestry in a culturally sensitive and ethical manner. In this project, we will utilize trans-ancestry genomic analyses to accelerate the identification of OCD risk loci, fine-map putative causal variants, and improve the performance of polygenic risk scores in diverse populations. We will also capitalize on rich clinical data to examine the genetics of treatment response, biologically plausible OCD subtypes, and symptom dimensions. Additionally, LATINO will help elucidate the diversity of the clinical presentations of OCD across cultures through various trainings developed and offered in collaboration with Latin American investigators. We believe this study will advance the important goal of global mental health discovery and equity.

Published
2023
Full Text
View/download PDF

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