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26 results on '"Kopacz, Agnieszka"'

1. Melflufen or pomalidomide plus dexamethasone for patients with multiple myeloma refractory to lenalidomide (OCEAN): a randomised, head-to-head, open-label, phase 3 study

Author

Schjesvold, Fredrik, Delimpasi, Sosana, Robak, Pawel, Coriu, Daniel, Nikolayeva, Anna, Tomczak, Waldemar, Pour, Ludek, Spicka, Ivan, Dimopoulos, Meletios-Athanasios, Masszi, Tamas, Doronin, Vadim, Minarik, Jiri, Salogub, Galina, Alekseeva, Yulia, Maisnar, Vladimir, Mikala, Gabor, Rosinol, Laura, Konstantinova, Tatiana, Lazzaro, Antonio, Liberati, Anna Marina, Symeonidis, Anargyros, Gatt, Moshe, Illes, Arpad, Abdulhaq, Haifaa, Dungarwalla, Moez, Grosicki, Sebastian, Hajek, Roman, Leleu, Xavier, Myasnikov, Alexander, Richardson, Paul G., Avivi, Irit, Deeren, Dries, Gironella, Mercedes, Hernandez-Garcia, Miguel Teodoro, Martinez Lopez, Joaquin, Newinger-Porte, Muriel, Ribas, Paz, Samoilova, Olga, Voog, Eric, Arnao-Herraiz, Mario, Carrillo-Cruz, Estrella, Corradini, Paolo, Dodlapati, Jyothi, Granell Gorrochategui, Miquel, Huang, Shang-Yi, Jenner, Matthew, Karlin, Lionel, Kim, Jin Seok, Kopacz, Agnieszka, Medvedeva, Nadezhda, Min, Chang-Ki, Mina, Roberto, Palk, Katrin, Shin, Ho-Jin, Sohn, Sang Kyun, Sonneveld, Pieter, Tache, Jason, Anagnostopoulos, Achilles, Arguiñano, Jose-Maria, Cavo, Michele, Filicko, Joanne, Garnes, Margaret, Halka, Janusz, Herzog-Tzarfati, Kathrin, Ipatova, Natalia, Kim, Kihyun, Krauth, Maria-Theresa, Kryuchkova, Irina, Lazaroiu, Mihaela Cornelia, Luppi, Mario, Proydakov, Andrei, Rambaldi, Alessandro, Rudzianskiene, Milda, Yeh, Su-Peng, Alcalá-Peña, Maria Magdalena, Alegre Amor, Adrian, Alizadeh, Hussain, Bendandi, Maurizio, Brearton, Gillian, Brown, Randall, Cavet, Jim, Dally, Najib, Egyed, Miklos, Hernández-Rivas, José Ángel, Kaare, Ain, Karsenti, Jean-Michel, Kloczko, Janusz, Kreisle, William, Lee, Je-Jung, Legiec, Wojciech, Machherndl-Spandl, Sigrid, Manda, Sudhir, Mateos, Maria-Victoria, Moiseev, Ivan, Moreb, Jan, Nagy, Zsolt, Nair, Santosh, Oriol-Rocafiguera, Albert, Osswald, Michael, Otero-Rodriguez, Paula, Peceliunas, Valdas, Plesner, Torben, Rey, Philippe, Rossi, Giuseppe, Stevens, Don, Suriu, Celia, Tarella, Corrado, Verlinden, Anke, Zannetti, Alain, Schjesvold, Fredrik H, Pour, Luděk, Špička, Ivan, Mikala, Gábor, Rosiñol, Laura, Symeonidis, Argiris, Moody, Victoria, Thuresson, Marcus, Byrne, Catriona, Harmenberg, Johan, Bakker, Nicolaas A, Hájek, Roman, and Richardson, Paul G

Published
2022
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2. A hybrid protocol CLAG-M, a possible player for the first-line therapy of patients with mixed phenotype acute leukemia. A Polish Adult Leukemia Group experience

Author

Karasek, Magdalena, primary, Armatys, Anna, additional, Skarupski, Marek, additional, Bołkun, Łukasz, additional, Budziszewska, Katarzyna, additional, Drozd-Sokołowska, Joanna, additional, Zarzycka, Ewa, additional, Mensah-Glanowska, Patrycja, additional, Gajewska, Małgorzata, additional, Hałka, Janusz, additional, Kopacz, Agnieszka, additional, Prejzer, Witold, additional, Chyrko, Olga, additional, Wróbel, Tomasz, additional, Wierzbowska, Agnieszka, additional, and Sobas, Marta, additional

Published
2024
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4. PB1999: TOBACCO SMOKING IN MDS PATIENTS – ANALYSIS FROM THE MDS PALG REGISTRY

Author

Machowicz, Rafal, primary, Lis, Karol, additional, Rytel, Jagoda, additional, Jachalska, Anna, additional, Szwedyk, Pawel, additional, Sosnia, Oktawia, additional, Wiater, Elzbieta, additional, Obara, Agata, additional, Krochmalczyk, Dorota, additional, Kopinska, Anna, additional, Gajewska, Malgorzata, additional, Masternak, Anna, additional, Kopacz, Agnieszka, additional, Olszewska-Szopa, Magdalena, additional, Golos, Aleksandra, additional, Subocz, Edyta, additional, Drozd-Sokolowska, Joanna, additional, Basak, Grzegorz, additional, and Mądry, Krzysztof, additional

Published
2023
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5. P491: DAY 14 MEASURABLE RESIDUAL DISEASE ASSESSMENT PREDICTS TREATMENT OUTCOMES IN PATIENTS WITH ACUTE MYELOID LEUKEMIA TREATED WITH INTENSIVE CHEMOTHERAPY - RESULTS OF THE PALG-AML1/2016 STUDY

Author

Wierzbowska, Agnieszka, primary, Pluta, Agnieszka, additional, Czyz, Anna, additional, Czemerska, Magdalena, additional, Mikulski, Damian, additional, Stelmach, Piotr, additional, Libura, Marta, additional, Giebel, Sebastian, additional, Kopinska, Agnieszka, additional, Wozniczka, Krzysztof, additional, Helbig, Grzegorz, additional, Wojcik, Karol, additional, Razny, Malgorzata, additional, Sobas, Marta, additional, Wróbel, Tomasz, additional, Szczepaniak, Andrzej, additional, Gil, Lidia, additional, Dutka, Magdalena, additional, Bieniaszewska, Maria, additional, Maciej Zaucha, Jan, additional, Gromek, Tomasz, additional, Hus, Marek, additional, Cichocka, Edyta, additional, Halka, Janusz, additional, Patkowska, Elzbieta, additional, Wozniak, Jolanta, additional, Obara, Agata, additional, Kopacz, Agnieszka, additional, Dulik, Katarzyna, additional, Holowiecki, Jerzy, additional, Soin, Michał, additional, Fendler, Wojciech, additional, Rustani, Andi, additional, Kaner, Justin, additional, Mencia-Trinchant, Nuria, additional, Desai, Pinkal, additional, Lee, Sangmin, additional, Samuel, Michael, additional, Ritchie, Ellen, additional, Guzman, Monica, additional, and Roboz, Gail, additional

Published
2023
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7. Prospective Assessment of Measurable Residual Disease Kinetics in Intensively Treated Patients with Acute Myeloid Leukemia - Results of the Polish Adult Leukemia Group PALG-AML1/2016 Study

Author

Wierzbowska, Agnieszka, primary, Pluta, Agnieszka, additional, Czyz, Anna, additional, Libura, Marta Antonina, additional, Giebel, Sebastian, additional, Stelmach, Piotr, additional, Czemerska, Magdalena, additional, Strzałka, Piotr, additional, Kopinska, Anna, additional, Wozniczka, Krzysztof, additional, Helbig, Grzegorz, additional, Wojcik, Karol, additional, Razny, Malgorzata, additional, Sobas, Marta Anna, additional, Wróbel, Tomasz, additional, Szczepaniak, Andrzej, additional, Gil, Lidia, additional, Dutka, Magdalena, additional, Bieniaszewska, Maria, additional, Gromek, Tomasz, additional, Hus, Marek, additional, Cichocka, Edyta, additional, Halka, Janusz, additional, Patkowska, Elzbieta, additional, Watek, Marzena, additional, Wozniak, Jolanta, additional, Lech-Marańda, Ewa, additional, Kopacz, Agnieszka, additional, Dulik, Katarzyna, additional, Holowiecki, Jerzy, additional, Soin, Michal, additional, Mikulski, Damian, additional, Perdas, Ewelina, additional, Fendler, Wojciech, additional, Sukkur, Ameenah, additional, Rustani, Andi, additional, Mencia Trinchant, Nuria, additional, Desai, Pinkal, additional, Lee, Sangmin, additional, Samuel, Michael, additional, Kaner, Justin D., additional, Ritchie, Ellen, additional, Guzman, Monica L., additional, and Roboz, Gail J., additional

Published
2022
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8. A Polish Acute Leukemia Group Prospective Multicenter Clinical Trial to Compare the Efficacy of Two Standard Induction Therapies (DA-90 vs DAC) and Two Standard Salvage Regimens (FLAG-IDA vs CLAG-M) in Acute Myeloid Leukemia (AML) Patients ≤ 60 Years Old (PALG-AML1/2016)

Author

Wierzbowska, Agnieszka, primary, Czyz, Anna, additional, Pluta, Agnieszka, additional, Libura, Marta Antonina, additional, Giebel, Sebastian, additional, Stelmach, Piotr, additional, Czemerska, Magdalena, additional, Krawiec, Kinga, additional, Kopinska, Anna, additional, Wozniczka, Krzysztof, additional, Helbig, Grzegorz, additional, Halka, Janusz, additional, Sobas, Marta Anna, additional, Wróbel, Tomasz, additional, Szczepaniak, Andrzej, additional, Gil, Lidia, additional, Dutka, Magdalena, additional, Bieniaszewska, Maria, additional, Gromek, Tomasz, additional, Hus, Marek, additional, Patkowska, Elzbieta, additional, Watek, Marzena, additional, Lech-Marańda, Ewa, additional, Kopacz, Agnieszka, additional, Dulik, Katarzyna, additional, Holowiecki, Jerzy, additional, Obara, Agata, additional, Cichocka, Edyta, additional, Gawronski, Krzysztof, additional, Mordak-Domagala, Monika, additional, Sukkur, Ameenah, additional, Rustani, Andi, additional, Desai, Pinkal, additional, Samuel, Michael, additional, Mencia Trinchant, Nuria, additional, Lee, Sangmin, additional, Kaner, Justin D., additional, Ritchie, Ellen, additional, Guzman, Monica L., additional, and Roboz, Gail J., additional

Published
2022
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9. Case-adjusted bortezomib-based strategy in routine therapy of relapsed/refractory multiple myeloma shown to be highly effective—A report by Polish Myeloma Study Group

Author

Walter-Croneck, Adam, Grzasko, Norbert, Soroka-Wojtaszko, Maria, Jurczyszyn, Artur, Torosian, Tigran, Rymko, Marcin, Nowicki, Adam, Druzd-Sitek, Agnieszka, Lech-Maranda, Ewa, Madro, Elzbieta, Zielinska, Patrycja, Grygoruk-Wisniowska, Iwona, Blonska, Danuta, Usnarska-Zubkiewicz, Lidia, Potoczek, Stanislaw, Iskierka, Elzbieta, Masternak, Anna, Holojda, Jadwiga, Dawidowska, Dorota, Gawron, Ludmila, Barchnicka, Agnieszka, Olszewska-Szopa, Magdalena, Rybicka, Malwina, Gontarska, Agnieszka, Jachalska, Anna, Rzepecki, Piotr, Subocz, Edyta, Boguradzki, Piotr, Charlinski, Grzegorz, Dzierzak-Mietla, Monika, Wisniewska-Piaty, Katarzyna, Swistek, Wojciech, Kopacz, Agnieszka, Blajer-Olszewska, Beata, Swiderska, Alina, and Dmoszynska, Anna

Published
2014
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10. Prognostic indicators in primary plasma cell leukaemia: a multicentre retrospective study of 117 patients

Author

Jurczyszyn, Artur, Radocha, Jakub, Davila, Julio, Fiala, Mark A., Gozzetti, Alessandro, Grząśko, Norbert, Robak, Paweł, Hus, Iwona, Waszczuk‐Gajda, Anna, Guzicka‐Kazimierczak, Renata, Atilla, Erden, Mele, Giuseppe, Sawicki, Waldemar, Jayabalan, David S., Charliński, Grzegorz, Szabo, Agoston G., Hajek, Roman, Delforge, Michel, Kopacz, Agnieszka, Fantl, Dorotea, Waage, Anders, Avivi, Irit, Rodzaj, Marek, Leleu, Xavier, Richez, Valentine, Knopińska‐Posłuszny, Wanda, Masternak, Anna, Yee, Andrew J., Barchnicka, Agnieszka, Druzd‐Sitek, Agnieszka, Guerrero‐Garcia, Thomas, Liu, Jieqi, Vesole, David H., and Castillo, Jorge J.

Published
2018
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11. Cyfrowe projekty w praktyce polonistycznej

Author

Kopacz, Agnieszka

Subjects
project, Polish language education, Polish language, didactics, creativity
Abstract

Digital projects in Polish language practice Even though distance learning intensified the tools, unfortunately, school practice shows that it is used as an analogue of analog instruments. The student is still not the creator, but only recreates the content learned in the lesson. There is not enough space in the classroom– stationary and remote office– to recover digital tools. The introduction of this type of activity is not easy– it is introduced with the need to fully use the area of application, methods, it also gives student and teachers development. The paper deals with one of the methods that enable creative and creative thinking– a project and how to implement it in Polish lessons. In the first part, the author presented a theoretical approach (research to date, strength) along with a methodical commentary and the purposefulness of using the method of working in the lessons. The details of the experience of the project and the benefits of its implementation were detailed. The author, as a working practitioner, shows in her observations on the specifics of the subject, corrections, possible modifications and supplements to existing studies. The second part is practical– it shows how to effectively implement a project at school, as well as examples of student work with an overview. The emphasis is on the appropriate sparring tools and what to consider in the planning plan. It shows where to look for inspiration and good practices, which can be expected for young teachers. The paper is not a compendium of knowledge about Polish studies projects. The most important issues, questions, questions that arise in connection with remote education and presents examples of– often proven– solutions. Non-standard observations are the added value of the text, look at the theory from the point of view of the everyday teacher at school.

Published
2021
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12. Grywalizacja w percepcji uczniów szkoły ponadpodstawowej.

Author

Jasiński, Krzysztof and Kopacz, Agnieszka

Abstract

Copyright of Przegląd Pedagogiczny is the property of Kazimierza Wielki University in Bydgoszcz and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2023
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13. The Prognostic Value of Early Measurable Residual Disease Assessment in Patients with Acute Myeloid Leukemia Treated with Intensive Chemotherapy - Preliminary Results of Polish Adult Leukemia Group PALG-AML1/2016 Study

Author

Wierzbowska, Agnieszka, primary, Pluta, Agnieszka, additional, Czyz, Anna, additional, Libura, Marta Antonina, additional, Giebel, Sebastian, additional, Czemerska, Magdalena, additional, Stelmach, Piotr, additional, Soin, Michal, additional, Kopinska, Anna, additional, Wozniczka, Krzysztof, additional, Helbig, Grzegorz, additional, Sobas, Marta, additional, Wróbel, Tomasz, additional, Szczepaniak, Andrzej, additional, Gil, Lidia, additional, Wojcik, Karol, additional, Razny, Malgorzata, additional, Dutka, Magdalena, additional, Bieniaszewska, Maria, additional, Halka, Janusz, additional, Gromek, Tomasz, additional, Hus, Marek, additional, Patkowska, Elzbieta, additional, Wozniak, Jolanta, additional, Cichocka, Edyta, additional, Obara, Agata, additional, Kopacz, Agnieszka, additional, Dulik, Katarzyna, additional, Holowiecki, Jerzy, additional, Mikulski, Damian, additional, Perdas, Ewelina, additional, Fendler, Wojciech, additional, Cruz, Nicole M., additional, Mencia-Trinchant, Nuria, additional, Desai, Pinkal, additional, Lee, Sangmin, additional, Samuel, Michael B., additional, Kaner, Justin D., additional, Ritchie, Ellen, additional, Guzman, Monica L., additional, and Roboz, Gail J., additional

Published
2021
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14. Demographic, Hematologic, and Clinical Features of Myelodysplastic Syndrome Patients: Results from the First Polish Myelodysplastic Syndrome Registry

Author

Mądry, Krzysztof, Machowicz, RafaŁ, Waszczuk-Gajda, Anna, Drozd-SokoŁowska, Joanna, HoŁowiecka, Beata Stella, Wiater, Elżbieta, Mital, Andrzej, Obara, Agata, Szmigielska-KapŁon, Anna, KoŁkowska-Lešniak, Agnieszka, Sikorska, Anna, Subocz, Edyta, Mendrek, WŁodzimierz, Szczepańska, Magdalena, Biedroń, Monika, Jachalska, Anna, Wasilewska, Ewa, Wojciechowska, MaŁgorzata, Guzicka-Kazimierczak, Renata, Kopacz, Agnieszka, Katinas, Katarzyna, Kruger, Witold, Dawidowska, Anna, Salamańczuk, Zoriana, Zawirska, Daria, Šwiderska, Alina, Jędrzejczak, WiesŁaw Wiktor, and Dwilewicz-Trojaczek, Jadwiga

Published
2015
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15. Effectiveness and attractiveness of gamification carried out during the COVID-19 pandemic in the perception of high school students.

Author

Jasiński, Krzysztof and Kopacz, Agnieszka

Subjects
HIGH school students, GAMIFICATION, COVID-19 pandemic, STEREOTYPES, LEARNING ability
Abstract

The gamification method has gained in popularity in recent years. Theoretical works in this field emphasize its attractiveness, which also affects the effectiveness of the implementation of tasks considered stereotypically as tedious and requiring concentration. By introducing game-specific elements into the learning process, participants usually engage in activities more, feel more motivated and remember the content discussed better. In the article, the authors attempt to answer the question of how the method of gamification is understood and assessed by high school students. To this end, they conducted surveys in two research groups: in the first, which participated in lessons based on gamification, and the second, in which such activities were not carried out. The text presents the theoretical assumptions related to the topic and the research part, presenting the aforementioned research process. [ABSTRACT FROM AUTHOR]

Published
2022
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16. Safety and Efficacy of Bendamustine Monotherapy in the First-Line Treatment of Patients with Chronic Lymphocytic Leukemia: Polish Lymphoma Research Group Real-Life Analysis

Author

Wołowiec, Dariusz, primary, Szymczyk, Agnieszka, additional, Potoczek, Stanisław, additional, Krochmalczyk, Dorota, additional, Zawirska, Daria, additional, Piotrowska, Magdalena, additional, Malenda, Agata, additional, Soroka-Wojtaszko, Maria, additional, Kopacz, Agnieszka, additional, Wąsik-Szczepanek, Ewa, additional, Graboś-Michalak, Jolanta, additional, Raźny, Małgorzata, additional, Wichary, Ryszard, additional, Bramowicz-Jarosz, Bożena, additional, Seweryn, Marek, additional, Długosz-Danecka, Monika, additional, and Hus, Iwona, additional

Published
2019
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17. Secondary plasma cell leukemia: a multicenter retrospective study of 101 patients

Author

Jurczyszyn, Artur, primary, Castillo, Jorge J., additional, Avivi, Irit, additional, Czepiel, Jacek, additional, Davila, Julio, additional, Vij, Ravi, additional, Fiala, Mark A., additional, Gozzetti, Alessandro, additional, Grząśko, Norbert, additional, Milunovic, Vibor, additional, Hus, Iwona, additional, Mądry, Krzysztof, additional, Waszczuk-Gajda, Anna, additional, Usnarska-Zubkiewicz, Lidia, additional, Dębski, Jakub, additional, Atilla, Erden, additional, Beksac, Meral, additional, Mele, Giuseppe, additional, Sawicki, Waldemar, additional, Jayabalan, David, additional, Charliński, Grzegorz, additional, Gyula Szabo, Agoston, additional, Hajek, Roman, additional, Delforge, Michel, additional, Kopacz, Agnieszka, additional, Fantl, Dorotea, additional, Waage, Anders, additional, Crusoe, Edvan, additional, Hungria, Vania, additional, Richardson, Paul, additional, Laubach, Jacob, additional, Guerrero-Garcia, Thomas, additional, Liu, Jieqi, additional, and Vesole, David H., additional

Published
2018
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18. Concomitance of monosomal karyotype with at least 5 chromosomal abnormalities is associated with dismal treatment outcome of AML patients with complex karyotype – retrospective analysis of Polish Adult Leukemia Group (PALG)

Author

Wierzbowska, Agnieszka, primary, Wawrzyniak, Ewa, additional, Siemieniuk-Rys, Monika, additional, Kotkowska, Aleksandra, additional, Pluta, Agnieszka, additional, Golos, Aleksandra, additional, Robak, Tadeusz, additional, Szarawarska, Marta, additional, Jaskowiec, Anna, additional, Duszenko, Ewa, additional, Rybka, Justyna, additional, Holojda, Jadwiga, additional, Grosicki, Sebastian, additional, Pienkowska-Grela, Barbara, additional, Woroniecka, Renata, additional, Ejduk, Anna, additional, Watek, Marzena, additional, Wach, Malgorzata, additional, Mucha, Barbara, additional, Skonieczka, Katarzyna, additional, Czyzewska, Maria, additional, Jachalska, Anna, additional, Klonowska, Agnieszka, additional, Iliszko, Mariola, additional, Knopinska-Posluszny, Wanda, additional, Jarmuz-Szymczak, Malgorzata, additional, Przybylowicz-Chalecka, Anna, additional, Gil, Lidia, additional, Kopacz, Agnieszka, additional, Holowiecki, Jerzy, additional, and Haus, Olga, additional

Published
2016
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19. Higher Prevalence of Chronic Kidney Disease in Myelodysplastic Syndromes Patients Compared to Age- Adjusted General Population - Results from the Polish Adult Leukemia Group (PALG) Registry

Author

Madry, Krzysztof, Jachalska, Anna, Szwedyk, Pawel, Sosnia, Oktawia, Wiater, Elzbieta, Obara, Agata, Krochmalczyk, Dorota, Kopinska, Anna, Gajewska, Małgorzata, Kulikowska De Nalecz, Anna, Kopacz, Agnieszka, Olszewska-Szopa, Magdalena, Golos, Aleksandra, Subocz, Edyta, Machowicz, Rafal, Hus, Iwona, Rydzewska-Rosołowska, Alicja, Wasińska-Krawczyk, Anna, Basak, Grzegorz, and Rydzewski, Andrzej

Abstract

Introduction

Published
2023
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20. Cladribine Added to Daunorubicin and Cytarabine Induction Regimen Prolongs Survival of Patients with Complex but Not Monosomal Karyotype Acute Myeloid Leukemia – Retrospective Analysis of Polish Adult Leukemia Group (PALG)

Author

Wierzbowska, Agnieszka, primary, Wawrzyniak, Ewa, additional, Siemieniuk-Rys, Monika, additional, Kotkowska, Aleksandra, additional, Pluta, Agnieszka, additional, Robak, Tadeusz, additional, Jaskowiec, Anna, additional, Duszenko, Ewa, additional, Szarawarska, Marta, additional, Rybka, Justyna, additional, Holojda, Jadwiga, additional, Grosicki, Sebastian, additional, Pienkowska-Grela, Barbara, additional, Woroniecka, Renata, additional, Ejduk, Anna, additional, Watek, Marzena, additional, Wach, Malgorzata, additional, Mucha, Barbara, additional, Skonieczka, Katarzyna, additional, Czyzewska, Maria, additional, Jachalska, Anna, additional, Klonowska, Agnieszka, additional, Iliszko, Mariola, additional, Knopinska-Posluszny, Wanda, additional, Jarmuz-Szymczak, Malgorzata, additional, Przybylowicz-Chalecka, Anna, additional, Gil, Lidia, additional, Kopacz, Agnieszka, additional, Holowiecki, Jerzy, additional, and Haus, Olga, additional

Published
2014
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21. Polish Myelodysplastic Syndromes Registry- Report of 15 Months of Activity.

Author

Dwilewicz-Trojaczek, Jadwiga, primary, Madry, Krzysztof, additional, Stella-Holowiecka, Beata, additional, Mital, Andrzej, additional, Szmigielska, Anna, additional, Obara, Agata, additional, Sikorska, Anita, additional, Nita, Ewa, additional, Mendrek, Wlodzimierz, additional, Wiater, Elzbieta, additional, Zalewska, Magdalena, additional, Biedron, Monika, additional, Jachalska, Anna, additional, Wasilewska, Ewa, additional, Wojciechowska, Malgorzata, additional, Kopacz, Agnieszka, additional, Nowicki, Adam, additional, Kolkowska, Agnieszka, additional, Guzicka-Kazimierczak, Renata, additional, Pedziwiatr, Maria, additional, Sedzimirska, Mariola, additional, Nowak, Ewa, additional, Blasiak, Anna, additional, Baranska, Ewa, additional, Soroka-Wojtaszko, Maria, additional, Gornik, Slawomir, additional, Kruger, Witold, additional, Katinas, Katarzyna, additional, Salamanczuk, Zoriana, additional, Sokolowska, Bozena, additional, Jedrzejczak, Wieslaw W., additional, and Deptala, Andrzej, additional

Published
2009
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22. Secondary plasma cell leukemia: a multicenter retrospective study of 101 patients.

Author

Jurczyszyn A, Castillo JJ, Avivi I, Czepiel J, Davila J, Vij R, Fiala MA, Gozzetti A, Grząśko N, Milunovic V, Hus I, Mądry K, Waszczuk-Gajda A, Usnarska-Zubkiewicz L, Dębski J, Atilla E, Beksac M, Mele G, Sawicki W, Jayabalan D, Charliński G, Gyula Szabo A, Hajek R, Delforge M, Kopacz A, Fantl D, Waage A, Crusoe E, Hungria V, Richardson P, Laubach J, Guerrero-Garcia T, Liu J, and Vesole DH

Subjects
Adult, Aged, Aged, 80 and over, Female, Follow-Up Studies, Humans, Immunologic Factors therapeutic use, Leukemia, Plasma Cell etiology, Leukemia, Plasma Cell mortality, Male, Middle Aged, Multiple Myeloma mortality, Multiple Myeloma therapy, Proteasome Inhibitors therapeutic use, Retrospective Studies, Survival Analysis, Transplantation, Autologous, Treatment Outcome, Leukemia, Plasma Cell therapy, Multiple Myeloma complications, Salvage Therapy methods, Stem Cell Transplantation
Abstract

This multicenter retrospective study included 101 patients (median age 62 years) with secondary plasma cell leukemia (sPCL). The median time from initial multiple myeloma diagnosis to sPCL was 31 months. Fifty-five out of 72 patients (75%) who received any therapy were treated with immunomodulators (IMiDs) and/or proteasome inhibitors (PIs), and 14/72 (19%) underwent salvage autologous stem cell transplantation (ASCT). The overall response rate in patients who received ASCT or PI (either alone or in combination) was higher than in those who did not (93% vs. 36% and 60% vs. 30%, respectively). The median overall survival (OS) in patients who received therapy was 4.2 months (95% CI: 1.3; 8.0) with a 1-year OS of 19%. Platelet count ≤100 × 10 9 /L at sPCL diagnosis was the only independent predictor of a poorer OS in treated patients (HR = 3.98, p = .0001). These findings suggest that patients with sPCL may benefit from salvage ASCT- and PI-based regimens.

Published
2019
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23. Comparable Efficacy of Idelalisib Plus Rituximab and Ibrutinib in Relapsed/refractory Chronic Lymphocytic Leukemia: A Retrospective Case Matched Study of the Polish Adult Leukemia Group (PALG).

Author

Puła B, Budziszewska BK, Rybka J, Gil L, Subocz E, Długosz-Danecka M, Zawirska D, Waszczuk-Gajda A, Iskierka-Jażdżewska E, Kopacz A, Szymczyk A, Czyż J, Lech-Marańda E, Warzocha K, and Jamroziak K

Subjects
Adenine analogs & derivatives, Adult, Aged, Aged, 80 and over, Case-Control Studies, Disease-Free Survival, Female, Humans, Leukemia, Lymphocytic, Chronic, B-Cell mortality, Male, Middle Aged, Piperidines, Poland, Purines therapeutic use, Quinazolinones therapeutic use, Retrospective Studies, Rituximab therapeutic use, Antineoplastic Agents therapeutic use, Leukemia, Lymphocytic, Chronic, B-Cell drug therapy, Neoplasm Recurrence, Local drug therapy, Pyrazoles therapeutic use, Pyrimidines therapeutic use
Abstract

Background/aim: There is limited amount of data available on the comparative efficacy of ibrutinib and idelalisib, the B-cell receptor inhibitors (BCRi) newly approved for relapsed/refractory chronic lymphocytic leukemia/small lymphocytic lymphoma (r/r CLL/SLL) treatment. The aim of our study was to analyze and compare the outcomes of real-world r/r CLL/SLL patients treated with these two BCRi in outside clinical trials., Patients and Methods: A comparative case matched 1:2 analysis was performed on idelalisib combined with rituximab and ibrutinib efficacy in 102 patients with r/r CLL/SLL from two observational studies of the Polish Adult Leukemia Group (PALG)., Results: Both therapies produced similar overall response rates (idelalisib plus rituximab 76.4% and ibrutinib 72.1%). Median progression-free survival (PFS) and overall survival (OS) in both groups were not reached. Furthermore, no significant difference was observed between both BCRi regimens in regard to PFS (HR=0.75, 95% CI=0.30-1.86, p=0.55) and OS (HR=0.65, 95%CI=0.26-1.68, p=0.39)., Conclusion: In summary, the results of this retrospective analysis suggest that idelalisib combined with rituximab and ibrutinib therapies have comparable activity in r/r CLL/SLL in daily clinical practice., (Copyright© 2018, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)

Published
2018
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24. Concomitance of monosomal karyotype with at least 5 chromosomal abnormalities is associated with dismal treatment outcome of AML patients with complex karyotype - retrospective analysis of Polish Adult Leukemia Group (PALG).

Author

Wierzbowska A, Wawrzyniak E, Siemieniuk-Rys M, Kotkowska A, Pluta A, Golos A, Robak T, Szarawarska M, Jaskowiec A, Duszenko E, Rybka J, Holojda J, Grosicki S, Pienkowska-Grela B, Woroniecka R, Ejduk A, Watek M, Wach M, Mucha B, Skonieczka K, Czyzewska M, Jachalska A, Klonowska A, Iliszko M, Knopinska-Posluszny W, Jarmuz-Szymczak M, Przybylowicz-Chalecka A, Gil L, Kopacz A, Holowiecki J, and Haus O

Subjects
Adult, Aged, Aged, 80 and over, Antineoplastic Combined Chemotherapy Protocols adverse effects, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Biomarkers, Combined Modality Therapy, Female, Hematopoietic Stem Cell Transplantation, Humans, Leukemia, Myeloid, Acute therapy, Male, Middle Aged, Poland, Prognosis, Retrospective Studies, Survival Analysis, Transplantation, Homologous, Treatment Outcome, Young Adult, Chromosome Aberrations, Karyotype, Leukemia, Myeloid, Acute genetics, Leukemia, Myeloid, Acute mortality, Monosomy
Abstract

Monosomal karyotype (MK) and complex karyotype (CK) are poor prognostic factors in acute myeloid leukemia (AML). A comprehensive analysis of cytogenetic and clinical factors influencing an outcome of AML-CK +  was performed. The impact of cladribine containing induction on treatment results was also evaluated. We analyzed 125 patients with AML-CK +  treated within PALG protocols. MK was found in 75 (60%) individuals. The overall complete remission (CR) rate of 66 intensively treated patients was 62% vs. 28% in CK +  MK - and CK +  MK +  group (p = .01). No difference in CR rate was observed between DA and DAC arms. The overall survival (OS) in intensively treated patients was negatively influenced by MK, karyotype complexity (≥5 abnormalities), and WBC >20 G/L in multivariate analysis. The addition of cladribine to DA regimen improved OS only in MK - but not in MK +  group. In conclusion, concomitance of MK with ≥5 chromosomal abnormalities is associated with dismal treatment outcome in AMK-CK + .

Published
2017
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25. Evaluation of energy drink intake in selected student groups.

Author

Kopacz A, Wawrzyniak A, Hamułka J, and Górnicka M

Subjects
Educational Measurement statistics & numerical data, Energy Intake, Humans, Poland, Energy Drinks statistics & numerical data, Students statistics & numerical data
Abstract

Background: Energy drinks are intended for people who work hard, both physically and mentally, particularly young people engaged in an active lifestyle., Objective: To assess the intake of energy drinks in a student group, during examinations and throughout an academic year., Materials and Methods: A survey was performed on 92 students attending the Faculty of Human Nutrition and Consumer Sciences (Warsaw University of Life Sciences--WULS) and those from the Faculty of Physical Education (University of Physical Education--UPE) in Warsaw., Results: Students consumed many more energy drinks during examinations (1424 +/- 1577 ml/week) than during the academic year (441 +/- 579 ml/week). About 30% more subjects from UPE drank such drinks, throughout both examinations and the academic year, compared to those from WULS. On average, most students drunk less than one can per day. During exams, only 49% students consumed an average of less than 125 ml of energy drinks per day, (WULS; 55% and UPE; 46%), whereas this rose to 84% during the academic year (WULS; 91% and UPA; 80%). The most popular brands were Tiger, Red Bull and Burn. CONCLUSIONS. It is important that due care and attention is exercised in consuming high amounts of energy drinks as they contain bioactive substances, including caffeine, inositol, taurine, glucuronolactone and vitamins of the group B. These all have specific effects on the body and can be a cause for concern if their intake is high.

Published
2013

26. [Studies on the determinants of energy drinks intake by students].

Author

Kopacz A, Wawrzyniak A, Hamułka J, and Górnicka M

Subjects
Adult, Energy Drinks adverse effects, Female, Humans, Incidence, Male, Poland epidemiology, Population Surveillance, Sleep Initiation and Maintenance Disorders chemically induced, Universities statistics & numerical data, Young Adult, Alcohol Drinking epidemiology, Energy Drinks statistics & numerical data, Energy Intake, Health Knowledge, Attitudes, Practice, Students statistics & numerical data
Abstract

Background: Energy drinks are among the most popular functional products. They contain bioactive substances which may produce beneficial effects on the body, but excessive consumption of energy drinks or use them in accordance with their intended use may be dangerous to health., Objective: The aim of the study was to assess determinants and circumstances of energy drinks consuming in selected group of students, their opinion and knowledge on energy drinks., Material and Method: The study was conducted in March 2011 in Warsaw and included 92 students from Warsaw University of Life Sciences (WULS) and from University of Physical Education (UPE). The data was collected using diagnostic survey., Results: Energy drinks consumed 67% of the respondents. The most common reason for drinking energy drinks was to stay awake (45.2%). They most often drank them during the examination session (21.0%) and afterwards they experienced stimulation (72.9%), but also palpitations (32.2%) and insomnia (25.8%). Students who consumed energy drinks confirmed that they are effective (88.7%) and tasty (41.9%), but dangerous for health (43.5%). Majority of all users of energy drinks (80.7%) mixed them with alcohol. Every fourth respondent did not read the composition of the consumed beverages., Conclusions: Energy drinks have been a popular food product among students. After energy drinks consumption students often felt agitated but also experienced negative symptoms. Young people have to pay attention to the composition of energy drinks, what proves their consciousness.

Published
2012

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