11,107 results on '"Kopylov AT"'
Search Results
2. Self-Satisfied: An end-to-end framework for SAT generation and prediction
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Serrano, Christopher R., Gallagher, Jonathan, Yamada, Kenji, Kopylov, Alexei, and Warren, Michael A.
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Computer Science - Machine Learning ,Computer Science - Artificial Intelligence ,Computer Science - Logic in Computer Science ,03D99 ,I.5.2 ,I.5.1 ,I.2.3 ,F.0 - Abstract
The boolean satisfiability (SAT) problem asks whether there exists an assignment of boolean values to the variables of an arbitrary boolean formula making the formula evaluate to True. It is well-known that all NP-problems can be coded as SAT problems and therefore SAT is important both practically and theoretically. From both of these perspectives, better understanding the patterns and structure implicit in SAT data is of significant value. In this paper, we describe several advances that we believe will help open the door to such understanding: we introduce hardware accelerated algorithms for fast SAT problem generation, a geometric SAT encoding that enables the use of transformer architectures typically applied to vision tasks, and a simple yet effective technique we term head slicing for reducing sequence length representation inside transformer architectures. These advances allow us to scale our approach to SAT problems with thousands of variables and tens of thousands of clauses. We validate our architecture, termed Satisfiability Transformer (SaT), on the SAT prediction task with data from the SAT Competition (SATComp) 2022 problem sets. Prior related work either leveraged a pure machine learning approach, but could not handle SATComp-sized problems, or was hybrid in the sense of integrating a machine learning component in a standard SAT solving tool. Our pure machine learning approach achieves prediction accuracies comparable to recent work, but on problems that are an order of magnitude larger than previously demonstrated. A fundamental aspect of our work concerns the very nature of SAT data and its suitability for training machine learning models. We both describe experimental results that probe the landscape of where SAT data can be successfully used for learning and position these results within the broader context of complexity and learning., Comment: 22 pages
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- 2024
3. Relative distances and peculiar velicities of 140 groups and clusters of galaxies at low redshifts: the Hubble diagram
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Kopylova, Flera G. and Kopylov, Alexander I.
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Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
To determine the relative distances and peculiar velocities of 140 groups and clusters of galaxies at low redshifts ($z$ < 0.12), we used the fundamental plane (FP) of early-type galaxies (from the Sloan Digital Sky Survey (SDSS) data). We constructed the Hubble diagram for the relative distances of galaxy groups/clusters versus their radial velocities in the cosmic microwave background (CMB) reference frame in the flat $\Lambda$ cold dark matter ($\Lambda$CDM) model ($\Omega_m=0.3$, $H_0=70$~km~s$^{-1}$ Mpc$^{-1}$). We have found that the standard logarithmic deviation for groups and clusters of galaxies on the Hubble diagram (minus peculiar velocities) is $\pm0.0173$ ($N$ = 140), which corresponds to a deviation of $70\pm2.8$~km~s$^{-1}$ Mpc$^{-1}$ in the Hubble constant. For a sample of galaxy systems ($N$ = 63), the X-ray luminosity of which is in an interval of (0.151--4)~$\times 10^{44}$~erg/s, this quantity turned out to be $70\pm2.1$~km~s$^{-1}$ Mpc$^{-1}$. The root-mean-square deviations of peculiar velocities with quadratic accounting for errors are $
^{1/2}$ = $714\pm7$~km/s and $600\pm7$~km/s, respectively. For five large superclusters of galaxies from the SDSS region, the average peculiar velocity relaive to the CMB reference frame is $+240\pm250$~km/s. We detected no outflow of galaxy systems from the void (Giant Void, $\alpha \approx 13^h, \delta \approx 40^\circ, z \approx 0.107$) formed by groups and clusters of galaxies., Comment: 10 pages, 5 figures. Accepted for publication in Astronomy Reports - Published
- 2024
4. Fundamental Plane of Groups and Clusters of Galaxies: Distances and Peculiar Velocities of Superclusters of Galaxies on Small Scales
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Kopylova, Flera G. and Kopylov, Alexander I
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
This work is a continuation of the work of Kopylova and Kopylov (2016) to build a fundamental plane (FP) of groups and clusters of galaxies -- here a sample of galaxies systems is increased from 94 to 172 objects. We have studied the ratios between the basic characteristics of groups and clusters of galaxies according to the archival data of SDSS, 2MASX and NED catalogs. Measured parameters ($\log L_K$, $\log R_e$ and $\log \sigma$) of clusters of galaxies determine the fundamental plane in the near infrared region: $L_K \propto R_e^{0.77\pm0.09} \sigma^{1.44\pm0.12}$. The form of the FP of groups/clusters is consistent with the FP of the early -- types of galaxies (SDSS, $r$-band) determined in the same way. Direct regression relative to the padius $\log r_e$ in the kpc gives a projection of the FP -- $\log R_e=0.98(\pm0.06)\,\log \sigma-0.56(\pm0.04)<\log \langle I_e \rangle+3.57(\pm0.07)$, that can be used to determine the distances of the systems of galaxies. The root-mean-square deviation of the FP zero-point is 0.07 which is equal to the 16\% error in determining the distance of the group or cluster of galaxies. For the first time, we measured the peculiar velocities of the superclusters of galaxies. The mean peculiar velocity of the 5 superclusters of galaxies relative to the CMB is $+75\pm360$~km~s$^{-1}$., Comment: 14 pages, 7 figures, 1 table. Astrophysical Bulletin, 2024, 79, 1. Key results in Figures 6 and 7
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- 2024
5. PHELEX: Two Series of Measurements in the Search for Dark Photons
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Kopylov, A., Orekhov, I., Petukhov, V., and Solomatin, A.
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High Energy Physics - Experiment - Abstract
The results of measurements in two series, each series of 4 Runs and about 50 days each Run, are presented. A multi-cathode counter with an iron cathode is used in these measurements. In both series we have observed some excess in count rates in sidereal time while no excess has been observed in terrestrial time. In the first series from 27.12.22 to 24.07.23 we have observed the excess in the period between 8 a.m. and 12 a.m. of sidereal time with a confidence level more than 6 \sigma, in the second series from 21.09.23 to 03.04.24 in the period between 6 p.m. and 10 p.m. of sidereal time with a confidence level more than 4 \sigma. The fact that in terrestrial time we do not observe a similar effect as in sidereal time suggests that probably this effect is of galactic origin and that this may be caused by dark photons. Future steps are suggested to validate these results., Comment: 8 pages, 6 figures, minor changes to the text to improve readability
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- 2024
6. Optical turbulence vertical distribution at the Peak Terskol Observatory and Mt. Kurapdag
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Shikhovtsev, A. Y., Qing, C., Kopylov, E. A., Potanin, S. A., and Kovadlo, P. G.
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Astrophysics - Instrumentation and Methods for Astrophysics ,Physics - Atmospheric and Oceanic Physics - Abstract
Characterization of atmospheric turbulence is essential to understanding image quality of astronomical telescopes and applying adaptive optics systems. In this study, the vertical distributions of optical turbulence at the Peak Terskol Observatory (43.27472N 42.50083E, 3127 m a.s.l.) using the Era-5 re-analysis, scintillation measurements and sonic anemometer data are investigated. For the reanalysis grid node closest to the observatory, vertical profiles of the structural constant of the air refractive index turbulent fluctuations $C^2_n$ were obtained. The calculated $C^2_n(z)$ vertical profiles are compared with the vertical distribution of turbulence intensity obtained from tomographic measurements with Shack-Hartmann sensor. The Fried parameter r0 at the location of Terskol Peak Observatory was estimated. Using combination of atmospheric models and scheme paramaterization of turbulence, $C^2_n(z)$ profiles at Mt. Kurapdag were obtained. The r0 values at the Peak Terskol Observatory are compared with estimated values of this length at the ten astronomical sites including Ali, Lenghu and Daocheng., Comment: 27 pages, 13 figures
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- 2024
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7. Halo Radius (Splashback Radius) of Groups and Clusters of Galaxies on small scales
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Kopylova, Flera G. and Kopylov, Alexander I.
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Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
We report the results of a study of the distribution of galaxies in the projection along the radius ($R \leq 3R_{200c}$) for 157~groups and clusters of galaxies in the local Universe (0.01 < $z$ < 0.10) with line-of-sight velocity dispersions~200~km~s$^{-1}$ < $ \sigma$ < 1100~km~s$^{-1}$. We introduce a new observed boundary for the halos of clusters of galaxies, which we identify with the splashback radius $R_{\rm{sp}}$. We also identified the core of groups/clusters of galaxies with the radius$R_c$. These radii are determined by the observed integrated distribution of the number of galaxies as a function of squared angular radius from the center of the group/cluster, which (usually) coincides with the brightest galaxy. We found for the entire sample that the boundary of dark matter $R_{\rm{sp}}$ for groups/clusters of galaxies is proportional to the radius $R_{\rm{200c}}$ of the virialized region. We measured the mean radius $\langle R_{\rm{sp}} \rangle = 1.14\pm0.02$~Mpc for groups of galaxies ($\sigma \leq 400$~km~s$^{-1}$) and $\langle R_{\rm{sp}} \rangle = 2.00\pm0.07$~Mpc for clusters of galaxies ($\sigma > 400$~km~s$^{-1}$). The mean ratio of radii is $\langle R_{\rm{sp}}/R_{\rm{200c}} \rangle = 1.40\pm0.02$}, or $\langle R_{\rm{sp}}/R_{\rm{200m}} \rangle = 0.88\pm0.02$., Comment: 15 pages, 7 figures, 2 tables. The article provides references to the X-ray luminosity of galaxy clusters and clarifies the descriptions of the columns
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- 2024
8. Efficient scaling and squaring method for the matrix exponential
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Blanes, Sergio, Kopylov, Nikita, and Seydaoğlu, Muaz
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Mathematics - Numerical Analysis ,15A16 ,G.1.3 ,G.1.7 - Abstract
This work presents a new algorithm to compute the matrix exponential within a given tolerance. Combined with the scaling and squaring procedure, the algorithm incorporates Taylor, partitioned and classical Pad\'e methods shown to be superior in performance to the approximants used in state-of-the-art software. The algorithm computes matrix--matrix products and also matrix inverses, but it can be implemented to avoid the computation of inverses, making it convenient for some problems. If the matrix A belongs to a Lie algebra, then exp(A) belongs to its associated Lie group, being a property which is preserved by diagonal Pad\'e approximants, and the algorithm has another option to use only these. Numerical experiments show the superior performance with respect to state-of-the-art implementations., Comment: 26 pages, 4 figures, 3 tables
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- 2024
9. Technical Design Report of the Spin Physics Detector at NICA
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The SPD Collaboration, Abazov, V., Abramov, V., Afanasyev, L., Akhunzyanov, R., Akindinov, A., Alekseev, I., Aleshko, A., Alexakhin, V., Alexeev, G., Alimov, L., Allakhverdieva, A., Amoroso, A., Andreev, V., Andronov, E., Anikin, Yu., Anischenko, S., Anisenkov, A., Anosov, V., Antokhin, E., Antonov, A., Antsupov, S., Anufriev, A., Asadova, K., Ashraf, S., Astakhov, V., Aynikeev, A., Azarkin, M., Azorskiy, N., Bagulya, A., Baigarashev, D., Baldin, A., Baldina, E., Barbashina, N., Barnyakov, A., Barsov, S., Bartkevich, A., Baryshevsky, V., Basharina, K., Baskakov, A., Baskov, V., Batista, M., Baturitsky, M., Bautin, V., Bedareva, T., Belokurova, S., Belova, A., Belyaeva, E., Berdnikov, A., Berdnikov, Ya., Berezhnoy, A., Berngardt, A., Bespalov, Yu., Bleko, V., Bliznyuk, L., Bogoslovskii, D., Boiko, A., Boikov, A., Bolsunovskya, M., Boos, E., Borisov, V., Borsch, V., Budkouski, D., Bulanova, S., Bulekov, O., Bunichev, V., Burtebayev, N., Bychanok, D., Casanova, A., Cesar, G., Chemezov, D., Chepurnov, A., Chen, L., Chmill, V., Chukanov, A., Chuzo, A., Danilyuk, A., Datta, A., Dedovich, D., Demichev, M., Deng, G., Denisenko, I., Denisov, O., Derbysheva, T., Derkach, D., Didorenko, A., Dima, M. -O., Doinikov, A., Doronin, S., Dronik, V., Dubinin, F., Dunin, V., Durum, A., Egorov, A., El-Kholy, R., Enik, T., Ermak, D., Erofeev, D., Erokhin, A., Ezhov, D., Fedin, O., Fedotova, Ju., Feofilov, G., Filatov, Yu., Filimonov, S., Frolov, V., Galaktionov, K., Galoyan, A., Garkun, A., Gavrishchuk, O., Gerasimov, S., Gerassimov, S., Gilts, M., Gladilin, L., Golovanov, G., Golovnya, S., Golovtsov, V., Golubev, A., Golubykh, S., Goncharov, P., Gongadze, A., Greben, N., Gregoryev, A., Gribkov, D., Gridin, A., Gritsay, K., Gubachev, D., Guo, J., Gurchin, Yu., Gurinovich, A., Gurov, Yu., Guskov, A., Gutierrez, D., Guzman, F., Hakobyan, A., Han, D., Harkusha, S., Hu, Sh., Igolkin, S., Isupov, A., Ivanov, A., Ivanov, N., Ivantchenko, V., Jin, Sh., Kakurin, S., Kalinichenko, N., Kambar, Y., Kantsyrev, A., Kapitonov, I., Karjavine, V., Karpishkov, A., Katcin, A., Kekelidze, G., Kereibay, D., Khabarov, S., Kharyuzov, P., Khodzhibagiyan, H., Kidanov, E., Kidanova, E., Kim, V., Kiryanov, A., Kishchin, I., Kokoulina, E., Kolbasin, A., Komarov, V., Konak, A., Kopylov, Yu., Korjik, M., Korotkov, M., Korovkin, D., Korzenev, A., Kostenko, B., Kotova, A., Kotzinian, A., Kovalenko, V., Kovyazina, N., Kozhin, M., Kraeva, A., Kramarenko, V., Kremnev, A., Kruchonak, U., Kubankin, A., Kuchinskaia, O., Kulchitsky, Yu., Kuleshov, S., Kulikov, A., Kulikov, V., Kurbatov, V., Kurmanaliev, Zh., Kurochkin, Yu., Kutuzov, S., Kuznetsova, E., Kuyanov, I., Ladygin, E., Ladygin, V., Larionova, D., Lebedev, V., Levchuk, M., Li, P., Li, X., Li, Y., Livanov, A., Lednicki, R., Lobanov, A., Lobko, A., Loshmanova, K., Lukashevich, S., Luschevskaya, E., Lyashko, A. L'vov I., Lysan, V., Lyubovitskij, V., Madigozhin, D., Makarenko, V., Makarov, N., Makhmanazarov, R., Maleev, V., Maletic, D., Malinin, A., Maltsev, A., Maltsev, N., Malkhasyan, A., Malyshev, M., Mamoutova, O., Manakonov, A., Marova, A., Merkin, M., Meshkov, I., Metchinsky, V., Minko, O., Mitrankov, Yu., Mitrankova, M., Mkrtchyan, A., Mkrtchyan, H., Mohamed, R., Morozova, S., Morozikhin, A., Mosolova, E., Mossolov, V., Movchan, S., Mukhamejanov, Y., Mukhamejanova, A., Muzyaev, E., Myktybekov, D., Nagorniy, S., Nassurlla, M., Nechaeva, P., Negodaev, M., Nesterov, V., Nevmerzhitsky, M., Nigmatkulov, G., Nikiforov, D., Nikitin, V., Nikolaev, A., Oleynik, D., Onuchin, V., Orlov, I., Orlova, A., Ososkov, G., Panzieri, D., Parsamyan, B., Pavzderin, P., Pavlov, V., Pedraza, M., Perelygin, V., Peshkov, D., Petrosyan, A., Petrov, M., Petrov, V., Petrukhin, K., Piskun, A., Pivovarov, S., Polishchuk, I., Polozov, P., Polyanskii, V., Ponomarev, A., Popov, V., Popovich, S., Prokhorova, D., Prokofiev, N., Prokoshin, F., Puchkov, A., Pudin, I., Pyata, E., Ratnikov, F., Rasin, V., Red'kov, V., Reshetin, A., Reznikov, S., Rogacheva, N., Romakhov, S., Rouba, A., Rudnev, V., Rusinov, V., Rusov, D., Ryltsov, V., Saduyev, N., Safonov, A., Sakhiyev, S., Salamatin, K., Saleev, V., Samartsev, A., Samigullin, E., Samoylov, O., Saprunov, E., Savenkov, A., Seleznev, A., Semak, A., Senkov, D., Sergeev, A., Seryogin, L., Seryubin, S., Shabanov, A., Shahinyan, A., Shavrin, A., Shein, I., Sheremeteva, A., Shevchenko, V., Shilyaev, K., Shimansky, S., Shinbulatov, S., Shipilov, F., Shipilova, A., Shkarovskiy, S., Shoukovy, D., Shpakov, K., Shreyber, I., Shtejer, K., Shulyakovsky, R., Shunko, A., Sinelshchikova, S., Skachkova, A., Skalnenkov, A., Smirnov, A., Smirnov, S., Snesarev, A., Solin, A., Solin jr., A., Soldatov, E., Solovtsov, V., Song, J., Sosnov, D., Stavinskiy, A., Stekacheva, D., Streletskaya, E., Strikhanov, M., Suarez, O., Sukhikh, A., Sukhovarov, S., Sulin, V., Sultanov, R., Sun, P., Svirida, D., Syresin, E., Tadevosyan, V., Tarasov, O., Tarkovsky, E., Tchekhovsky, V., Tcherniaev, E., Terekhin, A., Terkulov, A., Tereshchenko, V., Teryaev, O., Teterin, P., Tishevsky, A., Tokmenin, V., Topilin, N., Tsiareshka, P., Tumasyan, A., Tyumenkov, G., Usenko, E., Uvarov, L., Uzhinsky, V., Uzikov, Yu., Valiev, F., Vasilieva, E., Vasyukov, A., Vechernin, V., Verkheev, A., Vertogradov, L., Vertogradova, Yu., Vidal, R., Voitishin, N., Volkov, I., Volkov, P., Vorobyov, A., Voskanyan, H., Wang, H., Wang, Y., Xu, T., Yanovich, A., Yeletskikh, I., Yerezhep, N., Yurchenko, S., Zakharov, A., Zamiatin, N., Zamora-Saá, J., Zarochentsev, A., Zelenov, A., Zemlyanichkina, E., Zhabitsky, M., Zhang, J., Zhang, Zh., Zhemchugov, A., Zherebchevsky, V., Zhevlakov, A., Zhigareva, N., Zhou, J., Zhuang, X., Zhukov, I., Zhuravlev, N., Zinin, A., Zmeev, S., Zolotykh, D., Zubarev, E., and Zvyagina, A.
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High Energy Physics - Experiment ,Physics - Instrumentation and Detectors - Abstract
The Spin Physics Detector collaboration proposes to install a universal detector in the second interaction point of the NICA collider under construction (JINR, Dubna) to study the spin structure of the proton and deuteron and other spin-related phenomena using a unique possibility to operate with polarized proton and deuteron beams at a collision energy up to 27 GeV and a luminosity up to $10^{32}$ cm$^{-2}$ s$^{-1}$. As the main goal, the experiment aims to provide access to the gluon TMD PDFs in the proton and deuteron, as well as the gluon transversity distribution and tensor PDFs in the deuteron, via the measurement of specific single and double spin asymmetries using different complementary probes such as charmonia, open charm, and prompt photon production processes. Other polarized and unpolarized physics is possible, especially at the first stage of NICA operation with reduced luminosity and collision energy of the proton and ion beams. This document is dedicated exclusively to technical issues of the SPD setup construction.
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- 2024
10. Theory of Multimode Squeezed Light Generation in Lossy Media
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Kopylov, Denis A., Meier, Torsten, and Sharapova, Polina R.
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Quantum Physics ,Physics - Optics - Abstract
A unified theoretical approach to describe the properties of multimode squeezed light generated in a lossy medium is presented. This approach is valid for Markovian environments and includes both a model of discrete losses based on the beamsplitter approach and a generalized continuous loss model based on the spatial Langevin equation. For an important class of Gaussian states, we derive master equations for the second-order correlation functions and illustrate their solution for both frequency-independent and frequency-dependent losses. Studying the mode structure, we demonstrate that in a lossy environment no broadband basis without quadrature correlations between the different broadband modes exists. Therefore, various techniques and strategies to introduce broadband modes can be considered. We show that the Mercer expansion and the Williamson decomposition do not provide modes in which the maximal squeezing contained in the system can be measured. In turn, we find a new broadband basis that maximizes squeezing in the lossy system and present an algorithm to construct it., Comment: 23 pages, 7 figures
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- 2024
11. Pro-motility Preparation Protocol May Reduce the Rates of Failed Patency Capsule Among Patients with Crohn’s Disease in Clinical Remission
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Ukashi, Offir, Dotan, Arad, Borkovsky, Tom, Talan Asher, Adi, Thurm, Tamar, Hirsch, Ayal, Maharshak, Nitsan, Niv, Eva, Leshno, Moshe, Eliakim, Rami, Ben-Horin, Shomron, Kopylov, Uri, and Deutsch, Liat
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- 2024
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12. THBru attenuates diabetic cardiomyopathy by inhibiting RAGE-dependent inflammation
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Xu, Heng-hui, Hao, Sheng-xin, Sun, He-yang, Dong, Xin-xin, Lin, Yuan, Lou, Han, Zhao, Li-min, Tang, Ping-ping, Dou, Zi-jia, Han, Jing-jing, Du, Meng-han, Chen, Zhou-xiu, Kopylov, Philipp, Shchekochikhin, Dmitry, Liu, Xin, and Zhang, Yong
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- 2024
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13. Spark Plasma Sintering for high-speed diffusion welding of the ultrafine grained near-a Ti-5Al-2V alloy with high strength and corrosion resistance for nuclear engineering
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Chuvil'deev, Vladimir, Nokhrin, Aleksey, Kopylov, Vladimir, Boldin, Maksim, Vostokov, Mikhail, Gryaznov, Mikhail, Tabachkova, Nataliya, and Tryaev, Petr
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Condensed Matter - Materials Science - Abstract
The paper demonstrates the prospects of Spark Plasma Sintering (SPS) for the high-speed diffusion welding of the high-strength ultrafine-grained (UFG) near-a Ti-5Al-2V alloy. The effect of increased diffusion welding intensity in the UFG Ti alloys is discussed also. The welds of the UFG near-a-Ti-5Al-2V alloy obtained by SPS are featured by high density, strength, and corrosion resistance. The rate of weld sealing in the UFG alloys has been shown to depend on the heating rate non-monotonously (with a pronounced maximum). At the stage of continuous heating and isothermic holding, the kinetics of the weld sealing was found to be determined by the exponential creep rate, the intensity of which in the coarse-grained (CG) alloys is limited by the diffusion rate in the crystal lattice whereas in the UFG alloys it is limited by the grain boundary diffusion rate., Comment: 62 pages, 3 tables, 24 figures, 61 references
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- 2024
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14. Corrosion fatigue crack initiation in ultrafine-grained near-a titanium alloy PT7M prepared by Rotary Swaging
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Chuvil'deev, V. N., Kopylov, V. I., Berendeev, N. N., Murashov, A. A., Nokhrin, A. V., Grayznov, M. Yu., Shadrina, I. S., Tabachkova, N. Yu., Likhnitskii, C. V., Kotkov, D. N., and Tryaev, P. V.
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Condensed Matter - Materials Science - Abstract
The study focuses on corrosion fatigue processes taking place in an ultrafine-grained (UFG) near-a-titanium alloy Ti-2.5Al-2.6Zr (Russian industrial name PT7M) used in nuclear engineering. UFG structure formed with Rotary Swaging is found to increase resistance to corrosion fatigue. Parameters of the Basquin's equation are defined and the slope of the fatigue curve Sa-lg(N) is shown to depend (nonmonotonic dependence) on the UFG alloy annealing temperature. This effect can be explained with the patterns of microstructural evolution in a UFG alloy PT7M during annealing: (1) reduced density of lattice dislocations, (2) precipitation and dissolution of zirconium nanoparticles, (3) release of a''-phase particles causing internal stress fields along interphase (a-a'')-boundaries, and (4) intensive grain growth at elevated annealing temperatures. It is shown that the fatigue crack closure effect manifested as changing internal stress fields determined using XRD method may be observed in UFG titanium alloys., Comment: 54 pages, 2 tables, 19 figures, 64 referances
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- 2024
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15. Effect of severe plastic deformation realized by rotary swaging on the mechanical properties and corrosion resistance of near-a-titanium alloy Ti-2.5Al-2.6Zr
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Chuvil'deev, V. N., Kopylov, V. I., Nokhrin, A. V., Tryaev, P. V., Tabachkova, N. Yu., Chegurov, M. K., Kozlova, N. A., Mikhaylov, A. S., Ershova, A. V., Grayznov, M. Yu., Shadrina, I. S., and Likhnitskii, C. V.
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Condensed Matter - Materials Science - Abstract
The research aims to analyze the impact that severe plastic deformation arising during Rotary Swaging has on mechanical properties and corrosion resistance of a near-a-titanium alloy Ti-2.5Al-2.6Zr (Russian industrial name PT7M). The nature of corrosion decay in fine-grained alloys caused by hot salt corrosion is known to vary from pit corrosion to intercrystalline corrosion at the onset of recrystallization processes. Resistance to hot salt corrosion in a fine-grained titanium alloy Ti-2.5Al-2.6Zr is shown to depend on the structural-phase state of grain boundaries that varies during their migration as a result of covering corrosive doping elements (aluminum, zirconium) distributed in the crystal lattice of a titanium alloy., Comment: 37 pages, 15 figures, 39 references
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- 2024
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16. The BM@N spectrometer at the NICA accelerator complex
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Afanasiev, S., Agakishiev, G., Aleksandrov, E., Aleksandrov, I., Alekseev, P., Alishina, K., Astakhov, V., Atkin, E., Aushev, T., Azorskiy, V., Babkin, V., Balashov, N., Barak, R., Baranov, A., Baranov, D., Baranova, N., Barbashina, N., Baznat, M., Bazylev, S., Belov, M., Blau, D., Bocharnikov, V., Bogdanova, G., Bolozdynya, A., Bondar, E., Boos, E., Buryakov, M., Buzin, S., Chebotov, A., Chemezov, D., Chen, J. H., Demanov, A., Dementev, D., Dmitriev, A., Drnoyan, J., Dryablov, D., Dryuk, A., Dubinchik, B., Dulov, P., Egorov, A., Egorov, D., Elsha, V., Fediunin, A., Fedosimova, A., Filippov, I., Filozova, I., Finogeev, D., Gabdrakhmanov, I., Galavanov, A., Gavrischuk, O., Gertsenberger, K., Golosov, O., Golovatyuk, V., Grigoriev, P., Golubeva, M., Guber, F., Ibraimova, S., Idrisov, D., Idrissova, T., Iusupova, A., Ivashkin, A., Izvestnyy, A., Kabadzhov, V., Kanokova, Sh., Kapishin, M., Kapitonov, I., Karjavin, V., Karmanov, D., Karpushkin, N., Kattabekov, R., Kekelidze, V., Khabarov, S., Kharlamov, P., Khudaiberdyev, G., Khukhaeva, A., Khvorostukhin, A., Kiryushin, Yu., Klimai, P., Kolesnikov, V., Kolozhvari, A., Kopylov, Yu., Korolev, M., Kovachev, L., Kovalev, I., Kruglova, I., Kovalev, Yu., Kozlov, I., Kozlov, V., Kuklin, S., Kulish, E., Kurganov, A., Kutergina, V., Kuznetsov, A., Ladygin, E., Lanskoy, D., Lashmanov, N., Lebedev, I., Lenivenko, V., Lednicky, R., Leontiev, V., Liapin, D., Litvinenko, E., Ma, Y. G., Makankin, A., Makhnev, A., Malakhov, A., Mamaev, M., Martemianov, A., Martovitsky, E., Mashitsin, K., Merkin, M., Merts, S., Morozov, S., Murin, Yu., Musaev, K., Musulmanbekov, G., Myasnikov, A., Myktybekov, D., Nagdasev, R., Nemnyugin, S., Nikitin, D., Novozhilov, S., Olimov, Kh., Olimov, K., Palichik, V., Parfenov, P., Pelevanyuk, I., Peresunko, D., Piyadin, S., Platonova, M., Plotnikov, V., Podgainy, D., Pukhaeva, N., Ratnikov, F., Reshetova, S., Rogov, V., Romanov, I., Rufanov, I., Rukoyatkin, P., Rumyantsev, M., Rybakov, T., Sakulin, D., Sedykh, S., Serebryakov, D., Shabanov, A., Segal, I., Semak, A., Sergeev, S., Serikkanov, A., Sheremetev, A., Sheremeteva, A., Shchipunov, A., Shitenkov, M., Shopova, M., Shumikhin, V., Shutov, A., Shutov, V., Shodmonov, M., Slepnev, I., Slepnev, V., Slepov, I., Smirnov, A., Smolyanin, T., Solomin, A., Sorin, A., Sosnovtsev, V., Spaskov, V., Stavinskiy, A., Stekhanov, V., Stepanenko, Yu., Streletskaya, E., Streltsova, O., Strikhanov, M., Sukhov, E., Suvarieva, D., Taer, G., Taranenko, A., Tarasov, N., Tarasov, O., Teremkov, P., Terletsky, A., Teryaev, O., Tcholakov, V., Tikhomirov, V., Timoshenko, A., Tojiboev, O., Topilin, N., Tretyakova, T., Troshin, V., Truttse, A., Tserruya, I., Tskhay, V., Tyapkin, I., Ustinov, V., Vasendina, V., Velichkov, V., Volkov, V., Voronin, A., Voytishin, N., Yuldashev, B., Yurevich, V., Zamiatin, N., Zavertyaev, M., Zhang, S., Zhavoronkova, I., Zhezher, V., Zhigareva, N., Zinchenko, A., Zubankov, A., Zubarev, E., and Zuev, M.
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High Energy Physics - Experiment ,Physics - Instrumentation and Detectors - Abstract
BM@N (Baryonic Matter at Nuclotron) is the first experiment operating and taking data at the Nuclotron/NICA ion-accelerating complex.The aim of the BM@N experiment is to study interactions of relativistic heavy-ion beams with fixed targets. We present a technical description of the BM@N spectrometer including all its subsystems., Comment: 34 pages, 47 figures, 6 tables
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- 2023
17. Superplasticity-like behavior of ultrafine-grained austenitic steel 321
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Kopylov, V. I., Gryaznov, M. Yu., Shotin, S. V., Nokhrin, A. V., Likhnitskii, C. V., Chegurov, M. K., Chuvil'deev, V. N., and Tabachkova, N. Yu.
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Condensed Matter - Materials Science - Abstract
Hot rolled commercial metastable austenitic steel 321 with strongly elongated thin delta-ferrite particles in its microstructure was the object of investigations. Ultrafine-grained (UFG) microstructure in steel 321 was formed by Equal Channel Angular Pressing (ECAP) at 150 oC and 450 oC. When heating the UFG steel specimens, the nucleation of sigma-phase particles blocking the grain boundary migration was observed. The maximum elongation to failure (~250%) was achieved at the deformation temperature 750 oC. The process of superplastic deformation of the UFG steel 321 is controlled by simultaneous grain boundary sliding and power-law creep. The contribution of each process depends on the grain growth rate in the superplasticity regime as well as on defect accumulation on the grain boundaries. The fracture of the UFG steel 321 specimens has a cavitational character - an intensive formation of large elongated pores at the non-metallic particles as well as of the submicron pores at the sigma-phase particles in the course of superplastic deformation were observed., Comment: 41 pages, 2 tables, 15 figures, 78 references. arXiv admin note: text overlap with arXiv:2203.12102
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- 2023
18. Microstructure Thermal Stability and Superplastic Behavior of Al-6%Mg-0.12%Sc-0.10%Zr-0.10%(Yb, Er, Hf) Ultrafine-Grained Alloys
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Chuvil'deev, V. N., Gryaznov, M. Y., Shotin, S. V., Nokhrin, A. V., Nagicheva, G. S., Likhnitskii, C. V., Shadrina, I. S., Kopylov, V. I., Bobrov, A. A., Chegurov, M. K., and Pirozhnikova, O. E.
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Condensed Matter - Materials Science - Abstract
Superplastic behavior of ultrafine-grained (UFG) Al-6Mg-0.12Sc-0.10Zr-0.1X alloys, where X = Yb (Alloy #1-Yb), Er (Alloy #2-Er), and Hf (Alloy #3-Hf), has been studied. The total content of Sc, Zr, Yb, Er, Hf in the alloys was 0.32 wt.% (0.117-0.118 at.%). The alloys used for benchmarking were Al-6Mg-0.12Sc-0.20Zr (Alloy #4-Zr) and Al-6Mg-0.22Sc-0.10Zr (Alloy #5-Sc). Their UFG microstructure was formed with ECAP. Two different types of deformation behavior during superplasticity were demonstrated. A simultaneous increase in yield stress and elongation to failure during superplastic deformation was discovered. High deformation temperatures were shown to cause a competition between dynamic (strain-induced) grain growth and dynamic recrystallization, leading to a finer grain microstructure. The values of strain hardening factor (n), strain rate sensitivity factor (m), and superplastic deformation threshold stress (Sp) were determined. The impact of the type and concentration of alloying elements on the deformation behavior and dynamic grain growth of Al-6%Mg alloys was investigated. It was established that the maximum elongation to failure in Alloy #1-Yb and Alloy #2-Er is observed at lower deformation temperatures than in Alloy #4-Zr and Alloy #5-Sc. The superplastic properties of Alloy #3-Hf are superior to those of Alloy #4-Zr and Alloy #5-Sc with high content of alloying elements (in at.%). Alloy #1-Yb manifests good elongation to failure (910%) at low temperatures (400 oC). The satisfiability of Hart's criterion for calculating uniform deformation value under superplastic conditions was verified. It was demonstrated that cavitation when pores are formed in large Al3X particles at high temperatures causes early failure of aluminum alloys., Comment: 41 pages, 19 figures, 4 tables, 43 references
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- 2023
19. Relative Distances and Peculiar Velocities of 140 Groups and Clusters of Galaxies at Low Redshifts: the Hubble Diagram
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Kopylova, F. G. and Kopylov, A. I.
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- 2024
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20. Radiation Damage to SiPM Irradiated with Fast Neutrons
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Zamyatin, N. I., Kopylov, Yu. A., Streletskaya, E. A., Topko, B. L., and Sheremetyeva, A. I.
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- 2024
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21. Tashanta as a Promising Astronomical Site in the Altai Mountains Region in Russia: The First Results of the Astroclimate Study
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Bolbasova, L. A., Kopylov, E. A., and Potanin, S. A.
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- 2024
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22. Use of Anti-EGFR Aptamer Construct GR20hh for Controlled Delivery of Doxorubicin into Patient-Derived Glioblastoma Cells
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Ivanov, B. M., Antipova, O. M., Sliman, Ya. A., Samoylenkova, N. S., Pronin, I. N., Pavlova, G. V., and Kopylov, A. M.
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- 2024
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23. Specificity of Aptamers U2 and Gol1 to EGFR-Positive Human Glioblastoma Cells in Vitro
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Dzarieva, F. M., Shamadykova, D. V., Sluchanko, O. V., Pavlova, S. A., Fab, L. V., Ryabova, A. V., Panteleev, D. Yu., Kopylov, A. M., Usachev, D. Yu., Golovin, A. V., and Pavlova, G. V.
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- 2024
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24. A Recombinant Low Endotoxic Yersinia pseudotuberculosis Strain as an Overproducer of Yersinia pestis F1 Capsule Antigen
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Trunyakova, A. S., Platonov, M. E., Ivanov, S. A., Kopylov, P. Kh., Dentovskaya, S. V., and Anisimov, A. P.
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- 2024
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25. Mobile Differential Image Motion Monitor for Astroclimate Research
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Potanin, S. A., Kopylov, E. A., and Savvin, A. D.
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- 2024
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26. The First Orlicz Cohomology of General Discrete Groups
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Kopylov, Ya. A.
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- 2024
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27. Lambek Invariants of Commutative Squares in a Homological Category
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Kopylov, Yaroslav and Leshkov, Vadim
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Mathematics - Category Theory ,18G50 - Abstract
We consider the Lambek invariants (introduced by Joachim Lambek in 1964) in the context of semiexact and homological categories in the sense of Grandis. We generalize the Lambek isomorphism theorem to semiexact and homological categories. Throughout the text, for completeness we give proofs of some lemmas which are known in the additive case for the case of semiexact and homological categories.
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- 2023
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28. Do We Observe Dark Photons in PHELEX with a Multi-Cathode Counter?
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Kopylov, Anatoly, Orekhov, Igor, and Petukhov, Valery
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High Energy Physics - Experiment ,Physics - Instrumentation and Detectors - Abstract
In this paper, we report the results obtained in the PHoton ELectron EXperiment (PHELEX) during 208 days of measurements in the search for dark photons using a multi-cathode counter with an iron cathode. We observed a systematic excess of single-electron events in four runs, with a confidence level better than 5 sigma, in the time interval from 8-00 to 12-00 in sidereal time. The fact that we observe this effect in the stellar frame while detecting the excess of count rate in the solar frame in different time intervals is evidence that this effect is of galactic origin. This strengthens our argument that we are indeed observing the effect of dark photons, Comment: 7 pages, 5 figures
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- 2023
29. Isotope signatures of Carnivorans hair in the North-West of Russia: the role of diet, behavior and metabolism
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Eltsova, Liubov, Ivanova, Elena, Komov, Viktor, Mizgireva, Irina, Kopylov, Dmitry, Kuznetsova, Liudmila, Barinova, Maria, Platonova, Elena, Rumiantseva, Olga, Savkova, Irina, and Poddubnaya, Nadezhda
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- 2024
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30. The Latest Results of Experiment on The Search for Dark Photons With a Multicathode Counter
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Kopylov, A. V., Orekhov, I. V., and Petukhov, V. V.
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High Energy Physics - Experiment - Abstract
The technique is described of the search for dark photons with a multicathode counter. The aim of experiment is to search for diurnal variations of the effect from conversion of dark photons at the surface of the metallic cathode. The results obtained within 160 days of the measurements are presented, Comment: 7 pages, 6 figures, minor corrections
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- 2023
31. PowerNovo: de novo peptide sequencing via tandem mass spectrometry using an ensemble of transformer and BERT models
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Petrovskiy, Denis V., Nikolsky, Kirill S., Kulikova, Liudmila I., Rudnev, Vladimir R., Butkova, Tatiana V., Malsagova, Kristina A., Kopylov, Arthur T., and Kaysheva, Anna L.
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- 2024
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32. Square beams for optimal tiling in transmission electron microscopy
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Chua, Eugene Y. D., Alink, Lambertus M., Kopylov, Mykhailo, Johnston, Jake D., Eisenstein, Fabian, and de Marco, Alex
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- 2024
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33. Automated Production Control at PAO Koks
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Kolmakov, N. G., Nikolaev, O. B., and Kopylov, V. Yu.
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- 2024
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34. Fundamental Plane of Groups and Clusters of Galaxies: Distances and Pecular Velocities of Superclusters of Galaxies on Small Scales
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Kopylova, F. G. and Kopylov, A. I.
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- 2024
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35. The Lambek Invariants of Commutative Squares in a Homological Category
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Kopylov, Ya.A. and Leshkov, V.È.
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- 2024
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36. New Archexyelinae (Hymenoptera: Xyelidae) from the Triassic Madygen Formation of Kyrgyzstan
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Denisova, Elizaveta A., Kopylov, Dmitry S., and Rasnitsyn, Alexandr P.
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- 2024
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37. Production of $\pi^+$ and $K^+$ mesons in argon-nucleus interactions at 3.2 AGeV
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Afanasiev, S., Agakishiev, G., Aleksandrov, E., Aleksandrov, I., Alekseev, P., Alishina, K., Atkin, E., Aushev, T., Babkin, V., Balashov, N., Baranov, A., Baranov, D., Baranova, N., Barbashina, N., Baznat, M., Bazylev, S., Belov, M., Blau, D., Bogdanova, G., Bogoslovsky, D., Bolozdynya, A., Boos, E., Buryakov, M., Buzin, S., Chebotov, A., Chen, J., Dementev, D., Dmitriev, A., Dryablov, D., Dryuk, A., Dulov, P., Egorov, D., Elsha, V., Fediunin, A., Filippov, I., Filozova, I., Finogeev, D., Gabdrakhmanov, I., Galavanov, A., Gavrischuk, O., Gertsenberger, K., Golovatyuk, V., Golubeva, M., Guber, F., Iusupova, A., Ivashkin, A., Izvestnyy, A., Kabadzhov, V., Kapishin, M., Kapitonov, I., Karjavin, V., Karmanov, D., Karpushkin, N., Kattabekov, R., Kekelidze, V., Khabarov, S., Kharlamov, P., Khukhaeva, A., Khvorostukhin, A., Kiryushin, Yu., Klimai, P., Klimansky, D., Kolesnikov, V., Kolozhvari, A., Kopylov, Yu., Korolev, M., Kovachev, L., Kovalev, I., Kovalev, Yu., Kozlov, I., Kozlov, V., Kudryashov, I., Kuklin, S., Kulish, E., Kurganov, A., Kuznetsov, A., Ladygin, E., Lanskoy, D., Lashmanov, N., Lenivenko, V., Lednický, R., Leontiev, V., Litvinenko, E., Ma, Yu-G., Makankin, A., Makhnev, A., Malakhov, A., Martemianov, A., Martovitsky, E., Mashitsin, K., Merkin, M., Merts, S., Morozov, A., Morozov, S., Murin, Yu., Musulmanbekov, G., Myasnikov, A., Nagdasev, R., Nekrasowa, E., Nemnyugin, S., Nikitin, D., Novozhilov, S., Palchik, V., Pelevanyuk, I., Peresunko, D., Petukhov, O., Petukhov, Yu., Piyadin, S., Platonova, M., Plotnikov, V., Podgainy, D., Rogov, V., Rufanov, I., Rukoyatkin, P., Rumyantsev, M., Sakulin, D., Sergeev, S., Sheremetev, A., Sheremeteva, A., Shchipunov, A., Shitenkov, M., Shopova, M., Shumikhin, V., Shutov, A., Shutov, V., Slepnev, I., Slepnev, V., Slepov, I., Solomin, A., Sorin, A., Sosnovtsev, V., Spaskov, V., Stavinskiy, A., Stepanenko, Yu., Streletskaya, E., Streltsova, O., Strikhanov, M., Sukhov, N., Suvarieva, D., Taer, G., Tarasov, N., Tarasov, O., Teremkov, P., Terletsky, A., Teryaev, O., Tcholakov, V., Tikhomirov, V., Timoshenko, A., Topilin, N., Tretyakova, T., Tskhay, V., Tsvetkov, E., Tyapkin, I., Vasendina, V., Velichkov, V., Volkov, V., Voronin, A., Voytishin, N., Yurevich, V., Yumatova, I., Zamiatin, N., Zavertyaev, M., Zhang, S., Zherebtsova, E., Zhezher, V., Zhigareva, N., Zinchenko, A., Zubankov, A., Zubarev, E., and Zuev, M.
- Subjects
High Energy Physics - Experiment ,Nuclear Experiment - Abstract
First physics results of the BM@N experiment at the Nuclotron/NICA complex are presented on {\pi}+ and K+ meson production in interactions of an argon beam with fixed targets of C, Al, Cu, Sn and Pb at 3.2 AGeV. Transverse momentum distributions, rapidity spectra and multiplicities of $\pi^+$ and $K^+$ mesons are measured. The results are compared with predictions of theoretical models and with other measurements at lower energies., Comment: 29 pages, 20 figures
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- 2023
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38. Results of surgical treatment of posterior cranial fossa meningiomas
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I. S. Kopylov, A. V. Buzunov, and V. V. Stupak
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neurosurgery ,meningioma ,posterior cranial fossa ,surgical treatment ,Medicine - Abstract
Surgery of meningiomas of the posterior cranial fossa, due to its small volume and close anatomical relationship of neoplasms with the brain stem, cranial nerves, main arteries and venous collectors, remains one of the urgent problems of neurooncology. Despite the improvement of microsurgical techniques and neurophysiological control, maintaining a high level of quality of life after radical removal of meningiomas is still far from desired. Purpose of the study. Retrospective analysis and generalization of clinical results of surgical treatment of patients with meningiomas of the posterior cranial fossa. Material and methods. The paper analyzes the results of surgical treatment of 101 patient with meningiomas of the posterior cranial fossa of various localization (80 women (79.2 %) and 21 men (20.7 %), age 58.26 ± 1.00 years). According to the localization of meningiomas, they were distributed as follows: convexital – 49 (48.5 %), cerebellopontine angle – 22 (21.8 %), jugular foramen – 4 (4 %), petroclival – 16 (15.8 %), foramen magnum – 10 (9.9 %). Results. All patients underwent surgical removal of the formation. In 99 (98 %) one-stage and in 2 (1.9 %) cases of additional surgical intervention, in the form of external drainage according to Arendt and ventriculoperitoneal shunting, due to frolicking liquorodynamic disorders. Radical removal of meningioma (grade I according to Simpson scale) was achieved in 72 (71.3 %) of cases, tumor resection with coagulation of the tumor matrix zone (Simpson II) – in 21 (20.8 %), removal without resection and coagulation of the matrix, or leaving the extradural component of meningiomas (Simpson III) – in 8 (7.9 %). Conclusions. The results obtained on the basis of the complex use of modern neuroimaging diagnostic tools, microneurosurgery, optimal surgical approaches in combination with the mandatory intraoperative physiological control of the function of the brain stem and cranial nerves in the early postoperative period indicate an improvement in the functional state, and sometimes complete regression of the neurological symptoms in 58 (57.4 %) of operated patients. Complete regression of symptoms and restoration of the functional state was achieved in 30 (29.7 %) of cases, deterioration was noted in 17 (16.8 %) of the operated patients, mortality was 4.95 % (n = 5).
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- 2024
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39. A comparative study of circulating microRNA expression in blood in patients with coronary artery atherosclerosis and thoracic aortic aneurysm
- Author
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E. A.V. Ngo Bilong, S. V. Vasiliev, A. N. Rozhkov, D. A. Stonogina, D. Yu. Shchekochikhin, Y. I. Filippova, Ch. VK. Dzhafarova, N. P. Nurutdinov, A. V. Zhelankin, E. V. Generozov, A. S. Akselrod, Ph. Yu. Kopylov, and A. L. Syrkin
- Subjects
coronary artery disease ,thoracic aortic aneurysm ,microrna ,mir-21-5p ,mir-29b-5p ,mir-126-3p ,mir-205-5p ,Therapeutics. Pharmacology ,RM1-950 ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Aim. To compare the relative expression levels of circulating microRNAs associated with cardiovascular diseases, selected according to the literature review, in the blood plasma samples of patients with two variants of chronic vascular wall injury: coronary artery atherosclerosis (CAA) and thoracic aortic aneurysm (TAA).Material and methods. Patients admitted to the Clinical Center of the I. M. Sechenov First Moscow State Medical University (University Clinical Hospital No. 1) with CAA (n=45), TAA (n=38), as well as a control group (n=17) were included. Standard clinical and demographic, laboratory and instrumental data were collected in accordance with Russian clinical guidelines, and additional sampling and preparation of blood plasma of patients was carried out with further quantitative determination of the circulating microRNAs level via real-time polymerase chain reaction with reverse transcription. A comprehensive comparative analysis of the profiles of circulating microRNAs in the blood plasma of patients with two different variants of arterial pathology: atherosclerosis and aneurysmal changes, as well as with the control group was carried out. The levels of 12 circulating microRNAs were studied: miR-21-5p, -23a-3p, -29b-3p, -92a-3p, -126-5p, -143-3p, -145-5p, -146a-5p, -150-5p, -181b-5p, 2-23-3p and -451a.Results. The strongest difference with the control group in patients with CAA and TAA was observed for miR-21-5p, -29b-3p and -126-3p. Most of the circulating microRNAs studied were higher in the TAA group compared with CAA and controls these include miR-21-5p, -23a-3p, -29b-3p, -92a-3p, -126-3p, -126-5p, -146a-5p, -150-5p, -181b-5p. Significant differences between the pathology groups were noted for miR-126-3p and miR-205-5p. Some microRNAs (miR-143-3p, -92 a3, -195-5 p) can be used to diagnose coronary artery atherosclerosis, other microRNAs (miR-21-5p, -23a-3p, -126-3p, -126-5p, -451a) are TAA-specific.Conclusion. The present study showed significant differences in the circulating microRNAs in patients with atherosclerotic and aneurysmal lesions of the arteries in comparison with the control group. The most significant difference between norm and pathology was found for miR-21-5p, -29b-5p and -126-3p. The levels of miR-126-3p and -205-5p can be used to differentiate CAA and TAA.
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- 2024
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- View/download PDF
40. PowerNovo: de novo peptide sequencing via tandem mass spectrometry using an ensemble of transformer and BERT models
- Author
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Denis V. Petrovskiy, Kirill S. Nikolsky, Liudmila I. Kulikova, Vladimir R. Rudnev, Tatiana V. Butkova, Kristina A. Malsagova, Arthur T. Kopylov, and Anna L. Kaysheva
- Subjects
Medicine ,Science - Abstract
Abstract The primary objective of analyzing the data obtained in a mass spectrometry-based proteomic experiment is peptide and protein identification, or correct assignment of the tandem mass spectrum to one amino acid sequence. Comparison of empirical fragment spectra with the theoretical predicted one or matching with the collected spectra library are commonly accepted strategies of proteins identification and defining of their amino acid sequences. Although these approaches are widely used and are appreciably efficient for the well-characterized model organisms or measured proteins, they cannot detect novel peptide sequences that have not been previously annotated or are rare. This study presents PowerNovo tool for de novo sequencing of proteins using tandem mass spectra acquired in a variety of types of mass analyzers and different fragmentation techniques. PowerNovo involves an ensemble of models for peptide sequencing: model for detecting regularities in tandem mass spectra, precursors, and fragment ions and a natural language processing model, which has a function of peptide sequence quality assessment and helps with reconstruction of noisy sequences. The results of testing showed that the performance of PowerNovo is comparable and even better than widely utilized PointNovo, DeepNovo, Casanovo, and Novor packages. Also, PowerNovo provides complete cycle of processing (pipeline) of mass spectrometry data and, along with predicting the peptide sequence, involves the peptide assembly and protein inference blocks.
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- 2024
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- View/download PDF
41. Vision Deficit Is a New Marker of Cognitive Impairment
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N. M. Agarkov, A. E. Kopylov, R. E. Osmanov, N. V. Popova, M. A. Neudakhin, and A. A. Titov
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cataract ,primary open-angle glaucoma ,cognitive impairment ,visual acuity without correction ,marker of cognitive impairment ,visual deficit ,Ophthalmology ,RE1-994 - Abstract
Despite the frequent combination of cognitive impairments in patients with cataracts and glaucoma, the latter remain insufficiently studied with various visual deficits. The purpose: to study the association of visual deficits in cataracts and primary open–angle glaucoma with cognitive impairment. The clinical study involved 326 elderly patients with cataracts and 318 elderly patients with primary openangle glaucoma. The diagnosis of this ophthalmology was performed according to generally accepted methods. The degree of cognitive impairment was determined according to the Mini-Mental-State-Examination (MMSE) scale. Visual deficit was assessed by visual acuity without correction. It was found that with low visual deficit (visual acuity without correction of 0,51–0,60 and over 0,61) in the examined patients with cataract, the average score on the MMSE scale varied from 28,7 ± 0,4 to 28,8 ± 0,6 points, and in patients with primary open-angle glaucoma from 28,3 ± 0.5 to 28,5 ± 0.6 points with no significant differences in both cases. With severe visual deficit (visual acuity without correction to 0,20 and 0,21–0,30), the average score on the MMSE scale varied from 15,2 ± 0,3 to 17,4 ± 0,4 and from 13,8 ± 0,4 to 17,6 ± 0,3, respectively. The correlation coefficient between visual acuity without correction and the average MMSE score in patients with cataract was +0,436, and in patients with glaucoma — r = +0,482. The presence of an association of visual acuity without correction with cognitive dysfunction is also confirmed by regression analysis, which allows us to consider vision deficiency as a marker of cognitive impairment and can be used in monitoring them in patients with cataracts and glaucoma.
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- 2024
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42. Interstitial electrical stimulation for middle-aged, and elderly adults with early stages of knee osteoarthritis
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Nikita A. Burmatov, Konstantin S. Sergeev, Svetlana N. Luneva, Andrey A. Gerasimov, Semyon A. Kopylov, and Natalia A. Spiridonova
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osteoarthritis ,joint diseases ,interstitial electrical stimulation ,rehabilitation ,gonarthrosis ,Orthopedic surgery ,RD701-811 - Abstract
of early stages of deforming osteoarthritis of the knee joint. There is a need to explore the effectiveness and mechanisms of modern methods of electrical therapy and their impact on the quality of life due to close cause-and-effect relationship between the pain, inflammatory and destructive components of osteoarthritis (OA) as one of the most common conditions. The objective was to evaluate the effect of interstitial electrical stimulation (IES) as a monotherapy in the course of conservative treatment of early stages of gonarthrosis based on clinical and biochemical findings. Materials and methods Radiographic findings, skin electrometry (objective parameters of pain intensity), limb weight-bearing capacity, biochemical parameters of connective tissue matrix degradation in blood serum and 24-hour urine samples, and treatment satisfaction were explored in 43 patients. Patients who received a course of IES were assigned to the treatment group (n = 22) and patients who received standard treatment without IES constituted the control group (n = 21). Results Electrometric analysis showed a higher effectiveness of pain relief in the treatment group compared to the controls with asymmetry coefficient measuring 3.2 ± 0.31 versus 1.9 ± 0.4 at p > 0.05. The weight‑bearing scored 3.59 ± 0.34 versus 3.26 ± 0.2 at p > 0.05. The treatment group showed shorter treatment length with 13.21 ± 1.2 days versus 18.3 ± 1.2 days in the control group at p > 0.05 and a higher degree of satisfaction with outcomes scored 96.2 ± 2.59 in the treatment group versus 86.2 ± 3.17 in the control group. A statistically significant difference (p > 0.05) was established in the levels of free and total hydroxyproline characterizing the different intensity of collagen breakdown in the groups at the end of treatment. Discussion The IES used as an analgesic and anti-inflammatory therapy was shown to be highly effective with changes in the hydroxyproline level in the media suggesting a chondroprotective effect. The analysis and comparison of objective parameters demonstrated high effectiveness of IES in the treatment of early stages of gonarthrosis in middle-aged and elderly adults. Conclusion The IES used for treatment of early stages of gonarthrosis helps pain reducing the intensity of collagen destruction and improving weight-bearing.
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- 2024
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43. The splashback radius of groups and clusters of galaxies at low redshifts
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Kopylova, Flera G. and Kopylov, Alexander I.
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Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
We present a study of the distribution of galaxies along the radius of 157 groups and clusters of galaxies (200~km~s$^{-1}$ < $\sigma$ < 1100~km~s$^{-1}$) of the local Universe (0.01 < $z$ < 0.1). We introduced a new boundary of galaxy systems and identified it with the splashback radius $R_{sp}$. We also identified the central region of galaxy systems with a radius of $R_c$. These radii are defined by the observed integrated distribution of the total number of galaxies depending on the squared distance from the center of the groups/clusters coinciding, as a rule, with the brightest galaxy. We show that the radius $R_{sp}$ is proportional to the $R_{200c}$ (radius of the virialized region of a galaxy cluster) and to the radius of the central region $R_c$ with a slope close to 1. Among the obtained dependences of the radii on X-ray luminosity, the $\log R_{sp}$ - $\log L_X$ relation has the lowest scatter. We measured $
$ = $1.67\pm0.05$~Mpc for the total sample, $ $ = $1.14\pm0.14$~Mpc for galaxy groups with $\sigma \leq$ 400~km~s$^{-1}$, $ $ = $2.00\pm0.20$~Mpc for galaxy clusters with $\sigma$ > 400~km~s$^{-1}$. We found the average ratio of the radii $R_{sp}/R_{200c} = 1.40\pm0.02$ or $R_{sp}/R_{200m} = 0.88\pm0.02$.}, Comment: 7 pages, 3 figures, 1 table - Published
- 2023
44. Towards a possible discovery of dark photons with a multi-cathode counter
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Kopylov, A., Orekhov, I., and Petukhov, V.
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High Energy Physics - Experiment - Abstract
The main points of experiment on the search of dark photons using multy-cathode counter are outlined. The evidence base to prove that the observed effect is really from dark photons is formulated. First data on diurnal variations are presented. The possible interpretation of the data is given for the case if they are expanded in future measurements., Comment: 7 pages, 3 figures, proceeding for 6th International Conference on Particle Physics and Astrophysics
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- 2022
45. Extended range proteomic analysis of blood plasma from schizophrenia patients
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Denis V. Petrovskiy, Tatiana V. Butkova, Kirill S. Nikolsky, Arthur T. Kopylov, Valeriya I. Nakhod, Liudmila I. Kulikova, Kristina A. Malsagova, Nikolai D. Kibrik, Vladimir R. Rudnev, Alexander A. Izotov, and Anna L. Kaysheva
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proteins ,de novo identification ,PowerNovo ,schizophrenia ,serum ,post-translational modifications ,Biology (General) ,QH301-705.5 - Abstract
IntroductionThe high prevalence of schizophrenia worldwide makes it necessary to proceed from subjective assessment of patient’s clinical symptoms in diagnosis making to searching for circulating blood biomarkers. On the one hand, searching for molecular markers and targets for therapeutics will make it possible to refine and detail the molecular mechanisms of pathology development, while on the other hand, it will offer new opportunities for elaborating novel approaches to disease diagnosis and enhance efficacy and timeliness of drug therapy.MethodsIn this study, we performed an extended-range proteomic analysis of plasma samples collected from 48 study subjects with confirmed diagnosis of schizophrenia and 50 healthy volunteers. The high-resolution tandem mass spectra recorded in the data-dependent acquisition mode were analyzed using the MaxQuant algorithm for the library of known protein sequences and the PowerNovo algorithm for de novo protein sequencing.ResultsIt was demonstrated that both strategies show similar results for high-abundance proteins (≥1 μg/mL). For mid-abundance (10 ng/mL – 1 μg/mL) and low-abundance (
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- 2024
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46. Short-term effectiveness and safety of ustekinumab and vedolizumab in elderly and non-elderly patients with Crohn’s disease: a comparative study
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Lior Dar, Uria Shani, Arad Dotan, Offir Ukashi, Shomron Ben-Horin, Uri Kopylov, and Asaf Levartovsky
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Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Background: Inflammatory bowel disease (IBD) presents unique challenges in elderly patients due to comorbidities and treatment-related risks. Objectives: This study evaluates ustekinumab (UST) and vedolizumab (VDZ) efficacy and safety in elderly Crohn’s disease (CD) patients. Design: A retrospective cohort study at a tertiary medical center. Methods: CD patients aged ⩾60 years (elderly) treated with UST, compared to non-elderly (
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- 2024
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47. Bowel cleansing quality evaluation in colon capsule endoscopy: what is the reference standard?
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Benedicte Schelde-Olesen, Anastasios Koulaouzidis, Ulrik Deding, Ervin Toth, Konstantinos John Dabos, Abraham Eliakim, Cristina Carretero, Begoña González-Suárez, Xavier Dray, Thomas de Lange, Hanneke Beaumont, Emanuele Rondonotti, Uri Kopylov, Pierre Ellul, Enrique Pérez-Cuadrado-Robles, Alexander Robertson, Irene Stenfors, Alejandro Bojorquez, Stefania Piccirelli, Gitte Grunnet Raabe, Reuma Margalit-Yehuda, Isabel Barba, Giulia Scardino, Salome Ouazana, and Thomas Bjørsum-Meyer
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Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Background: The diagnostic accuracy of colon capsule endoscopy (CCE) depends on a well-cleansed bowel. Evaluating the cleansing quality can be difficult with a substantial interobserver variation. Objectives: Our primary aim was to establish a standard of agreement for bowel cleansing in CCE based on evaluations by expert readers. Then, we aimed to investigate the interobserver agreement on bowel cleansing. Design: We conducted an interobserver agreement study on bowel cleansing quality. Methods: Readers with different experience levels in CCE and colonoscopy evaluated bowel cleansing quality on the Leighton–Rex scale and Colon Capsule CLEansing Assessment and Report (CC-CLEAR), respectively. All evaluations were reported on an image level. A total of 24 readers rated 500 images on each scale. Results: An expert opinion-based agreement standard could be set for poor and excellent cleansing but not for the spectrum in between, as the experts agreed on only a limited number of images representing fair and good cleansing. The overall interobserver agreement on the Leighton–Rex full scale was good (intraclass correlation coefficient (ICC) 0.84, 95% CI (0.82–0.85)) and remained good when stratified by experience level. On the full CC-CLEAR scale, the overall agreement was moderate (ICC 0.62, 95% CI (0.59–0.65)) and remained so when stratified by experience level. Conclusion: The interobserver agreement was good for the Leighton–Rex scale and moderate for CC-CLEAR, irrespective of the reader’s experience level. It was not possible to establish an expert-opinion standard of agreement for cleansing quality in CCE images. Dedicated training in using the scales may improve agreement and enable future algorithm calibration for artificial intelligence supported cleansing evaluation. Trial registration: All included images were derived from the CAREforCOLON 2015 trial (Registered with The Regional Health Research Ethics Committee (Registration number: S-20190100), the Danish data protection agency (Ref. 19/29858), and ClinicalTrials.gov (registration number: NCT04049357)).
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- 2024
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48. Comparative Analysis of Traditional Machine Learning Approaches for Time Series Clustering Under Colored Noise
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Lukianchenko, Petr, Kopylov, Daniel, Filipe, Joaquim, Editorial Board Member, Ghosh, Ashish, Editorial Board Member, Zhou, Lizhu, Editorial Board Member, and Gibadullin, Arthur, editor
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- 2024
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49. Greedy Algorithm for Fast Finding Curvilinear Symmetry of Binary Raster Images
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Seredin, Oleg, Liakhov, Daniil, Lomov, Nikita, Kushnir, Olesia, Kopylov, Andrei, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Ignatov, Dmitry I., editor, Khachay, Michael, editor, Kutuzov, Andrey, editor, Madoyan, Habet, editor, Makarov, Ilya, editor, Nikishina, Irina, editor, Panchenko, Alexander, editor, Panov, Maxim, editor, Pardalos, Panos M., editor, Savchenko, Andrey V., editor, Tsymbalov, Evgenii, editor, Tutubalina, Elena, editor, and Zagoruyko, Sergey, editor
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- 2024
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50. On Asymptotic and Continuous Group Orlicz Cohomology
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Kopylov, Yaroslav and Sequeira, Emiliano
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Mathematics - Metric Geometry ,Mathematics - Group Theory - Abstract
We generalize some results on asymptotic and continuous group $L^p$-cohomology to Orlicz cohomology. In particular, we show that asymptotic Orlicz cohomology is a quasi-isometry invariant and that both notions coincide in the case of a locally compact second countable group. The case of degree $1$ is studied in more detail., Comment: To appear at Annales de l'Institut Fourier
- Published
- 2022
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