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144 results on '"Koretz K"'

5. 144P A personalised sequencing approach for liquid biopsy-based detection of recurrent disease in early-stage breast cancer

Author

Janni, W., primary, Huober, J., additional, Huesmann, S., additional, Pipinikas, C., additional, Braun, T., additional, Müller, V., additional, Marsico, G., additional, Fink, A., additional, Freire-Pritchett, P., additional, Koretz, K., additional, Knape, C., additional, de Gregorio, A., additional, Rack, B., additional, Friedl, T.W.P., additional, Wiesmueller, L., additional, Möller, P., additional, Howarth, K., additional, Pantel, K., additional, and Rosenfeld, N., additional

Published
2021
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11. Die Expression von Immun-Checkpoint Molekülen und Liganden in Oropharyngealen Plattenepithelkarzinomen (OPSCC) hängt vom HPV Status ab und wird durch Demethylierung moduliert.

Author

Fehn, A, additional, Ezic, J, additional, Brunner, C, additional, Theodoraki, Marie-Nicole, additional, Döscher, J, additional, Schuler, P, additional, Greve, J, additional, Marienfeld, R, additional, Koretz, K, additional, Hoffmann, T, additional, and Laban, S, additional

Published
2020
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24. Constitutive and induced expression of APO-1, a new member of the nerve growth factor/tumor necrosis factor receptor superfamily, in normal and neoplastic cells

Author

Leithauser, F., Jens Dhein, Mechtersheimer, G., Koretz, K., Bruderlein, S., Henne, C., Schmidt, A., Debatin, K. -M, Krammer, P. H., and Moller, P.

Subjects
Adult, Male, T-Lymphocytes, Membrane Proteins, Receptors, Nerve Growth Factor, Immunohistochemistry, Receptors, Tumor Necrosis Factor, Molecular Weight, Antigens, CD, Organ Specificity, Reference Values, Multigene Family, Neoplasms, Antigens, Surface, Humans, Female, fas Receptor, Skin
Abstract

APO-1 is a 48 kilodalton transmembrane, cysteine-rich glycoprotein identical with the Fas antigen which belongs to the nerve growth factor/tumor necrosis factor receptor superfamily. Cross-linking of APO-1 induces apoptotic cell death in sensitive cells.As suggested by our preliminary results, APO-1 expression is not restricted to cells of the hematopoietic lineage. We therefore investigated APO-1 expression in normal human tissues and in various epithelial and nonepithelial tumors.We show by immunohistochemistry that APO-1 is a non-lineage antigen constitutively expressed in a variety of epithelial cells. This includes the basal layers of various squamous epithelia, transitional epithelium and columnar epithelium of the biliary tract and intestine. Among the epithelial cell types of the reproductive system of both genders, APO-1 expression is complex. Except the satellite cells of autonomic ganglia, all cells of the nervous tissue are APO-1-negative. Among mesenchymal cells, constitutive APO-1 expression is rare but detectable in various kinds of activated cells, e.g. fibroblasts, osteoblasts, and subpopulations of endothelial cells. Within the immune system, APO-1 is broadly distributed among histiocytic cells but restricted to minor subpopulations of peripheral T and B cells. Immature T cells, i.e., thymocytes, do not express detectable APO-1-antigen. Expression of APO-1 was induced in phytohemagglutinin activated T cells and in a mammary carcinoma cell line by interferon-gamma alone and in combination with tumor necrosis factor alpha. Consistently, there was an in situ induction of APO-1 in several types of glandular epithelium in microtopographic association with lymphohistiocytic infiltrates. This inflammation-associated APO-1 induction went along with increased expression of this molecule within the lymphocytic compartment of the lesion. In tumors. APO-1 expression was heterogeneous. In comparison to their normal counterparts, some tumors showed abnormal hypo-expression or loss of APO-1. However, abnormal neo-expression was also found.Tissue distribution, in vitro expression, and reaction upon cytokine-induced activation suggest that APO-1 might not only transmit apoptotic signals but might play a more general role in growth control.

Published
1993

49. Ultrasound-guided large-core needle biopsies of breast lesions: analysis of 962 cases to determine the number of samples for reliable tumour classification.

Author

Sauer, G., Deissler, H., Strunz, K., Helms, G., Remmel, E., Koretz, K., Terinde, R., and Kreienberg, R.

Subjects
TUMORS, BIOPSY, CANCER patients, CLINICAL pathology, CANCER, MEDICAL imaging systems, BREAST tumor diagnosis, RESEARCH, ULTRASONIC imaging, RESEARCH evaluation, RESEARCH methodology, MEDICAL cooperation, EVALUATION research, COMPARATIVE studies, BREAST tumors, NEEDLE biopsy
Abstract

The objective of this one-institutional study was to determine the number of large-core needle biopsies (LCNB), under three-dimensional ultrasound (3D-US) validation, that are sufficient to obtain a reliable histological diagnosis of a sonographically detectable breast lesion. Over an 28-month period, 962 sonographically guided LCNB were performed under 3D-US validation to assess 962 breast lesions. All biopsies were carried out with an automated core biopsy device fitted with 14-gauge (22 mm excursion) needles. Data of 962 biopsied breast lesions were gathered. Surgical follow-up was available for 659 lesions. Breast malignancies were diagnosed by ultrasound-guided LCNB with a sensitivity of 98.2% by performing three cores per lesion. In few cases, the open surgical specimen revealed the presence of invasive carcinomas in contrast to initial LNCB-based classification as ductal carcinomas in situ (DCIS, 11 lesions), lobular carcinoma in situ (one lesion), and atypical ductal hyperpasia (one lesion). Owing to disagreement between classification based on breast-imaging and histological findings, eight of these tumours were subsequently excised. Of the lesions that were removed at the patients' requests despite benign LCNB diagnosis, two were infiltrating carcinoma and one a DCIS. We demonstrate that three 3D-US-guided percutaneous core specimens are sufficient to achieve tissue for a reliable histological assessment of sonographically detectable breast lesions and allow the detection of malignancies with high sensitivity and low rate of false-negative diagnoses. [ABSTRACT FROM AUTHOR]

Published
2005
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50. Comparative evaluation of integrin alpha- and beta-chain expression in colorectal carcinoma cell lines and in their tumours of origin.

Author

Koretz, K, Brüderlein, S, Henne, C, Fietz, T, Laqué, M, and Möller, P

Subjects
CELL receptors, COLON tumors, COMPARATIVE studies, FLOW cytometry, IMMUNOHISTOCHEMISTRY, RESEARCH methodology, MEDICAL cooperation, MONOCLONAL antibodies, RECTUM tumors, RESEARCH, EVALUATION research, CANCER cell culture
Abstract

The integrin family consists of broadly expressed cell surface adhesion receptors, each member of which is composed of a non-covalently linked alpha/beta heterodimer. Integrin receptors are involved in the interaction with matrix proteins and may contribute to invasion and metastasis of carcinomas. To examine the biological role integrins play in colorectal carcinoma we compared the expression of integrin alpha- and beta-subunits in situ and in vitro. Eight newly established cell lines derived from immunohistochemically characterized colorectal carcinomas together with two sublines obtained after nude mouse passage and the commonly used colon carcinoma lines HT-29, SW480, SW620, and COLO 205 were investigated by immunocytochemistry and flow cytometry. The carcinomas in situ expressed alpha 1-, alpha 2-, alpha 3-, alpha 6-, alpha v- and beta 1-subunits in variable amounts while being devoid of alpha 4, alpha 5, and beta 3. The individual integrin profile of the tumour in tissue was essentially maintained in vitro. However, a neo expression of the alpha 5 chain was found, together with an induction or increase in alpha 1, alpha 2, alpha 3, alpha v and beta 1 levels. No decrease in integrin subunit expression was observed. Standard-serum and serum-free medium revealed no striking differences in alpha- and beta-chain expression in the cell lines HT-29 and COLO 205. In serum-free medium, SW480 showed a slight increase of alpha 1 and alpha 5 and a decrease of alpha 3 and alpha v while SW620 expressed more alpha 1. We conclude that the great variability of adhesion receptor expression of the integrin family in colorectal carcinomas in situ is essentially maintained in vitro, although culture conditions which are only marginally influenced by serum factors unpredictably lead to some increase in expression or even induction of several integrin subunits. [ABSTRACT FROM AUTHOR]

Published
1994

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