30 results on '"Korsten, Koos"'
Search Results
2. RSV hospitalization in infancy increases the risk of current wheeze at age 6 in late preterm born children without atopic predisposition
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Korsten, Koos, Blanken, Maarten O., Buiteman, Brigitte J. M., Nibbelke, Elisabeth E., Naaktgeboren, Christiana A., Bont, Louis J., and Wildenbeest, Joanne G.
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- 2019
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3. Economic Burden and Health-Related Quality of Life of Respiratory Syncytial Virus and Influenza Infection in European Community-Dwelling Older Adults
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Mao, Zhuxin, Li, Xiao, Korsten, Koos, Bont, Louis, Butler, Christopher, Wildenbeest, Joanne, Coenen, Samuel, Hens, Niel, Bilcke, Joke, Beutels, Philippe, Nair, Harish, Campbell, Harry, Pollard, Andrew, Openshaw, Peter, Martinon-Torres, Federico, Heikkinen, Terho, Meijer, Adam, Fischer, Thea K, van den Berge, Maarten, Giaquinto, Carlo, Abram, Michael, Swanson, Kena, Rizkalla, Bishoy, Vernhes, Charlotte, Gallichan, Scott, Aerssens, Jeroen, Kumar, Veena, Molero, Eva, Coenen, Samuel/0000-0002-1238-8052, Mao, Zhuxin, Li, Xiao, Korsten, Koos, BONTE, Luis, Butler, Christopher, Wildenbeest, Joanne, COENEN, Samuel, HENS, Niel, Bilcke, Joke, Beutels, Philippe, and RESCEU Investigators
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Financial Stress ,Respiratory Syncytial Virus Infections ,elderly ,cost ,EQ5D ,Influenza, Human ,Humans ,Immunology and Allergy ,Biology ,Aged ,flu ,RSV ,Middle Aged ,outpatients ,health-related quality of life ,Hospitalization ,productivity loss ,Infectious Diseases ,Respiratory Syncytial Virus, Human ,influenza ,prospective study ,Independent Living ,Quality of Life ,Human medicine ,Respiratory Syncytial Virus ,costproductivity loss ,Human - Abstract
Background Respiratory syncytial virus (RSV) and influenza virus infections result in a considerable mortality and morbidity among the aging population globally. Influenza vaccination for older adults before the seasonal influenza epidemic has been evaluated to be cost-effective in many countries. Interventions against RSV in older adults are in the pipeline, and evaluating their cost-effectiveness is crucial for decision making. To inform such evaluations, our aim was to estimate average costs and health-related quality of life (HRQoL) in older adults with RSV and influenza infection. Methods The European RESCEU observational cohort study followed 1040 relatively healthy community-dwelling older adults aged 60 years and older during 2 consecutive winter seasons. Health care resource use and HRQoL were collected and analyzed during RSV episodes, and also during influenza episodes. Country-specific unit cost data were mainly obtained from national databases. Direct costs were estimated from a patient, health care provider, and health care payers’ perspective, whereas indirect costs were estimated from a societal perspective. Due to small sample size, no formal statistical comparisons were made. Results Thirty-six RSV and 60 influenza episodes were reported, including 1 hospitalization. Means (median; first-third quartile) of €26.4 (€5.5; 0–47.3) direct and €4.4 (€0; 0–0) indirect costs were reported per nonhospitalized RSV episode, and €42.5 (€36; 3.3–66.7) direct and €32.1 (€0; 0–0) indirect costs per nonhospitalized influenza episode. For RSV episodes, the utility value decreased from 0.896 (0.928; 0.854–0.953) to 0.801 (0.854; 0.712–0.937) from preseason to 1 week after symptom onset; for influenza, the change was from 0.872 (0.895; 0.828–0.953) to 0.664 (0.686; 0.574–0.797). Conclusions The average costs and HRQoL estimates of older adults treated outside the hospital can be used to inform the design of future studies and the decision making regarding interventions to prevent RSV infection in older adults. Larger studies are needed to provide better country-specific and complementary cost estimates and to allow for formal statistical comparison of costs between RSV and influenza. Clinical Trials Registration NCT03621930.
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- 2022
4. Economic burden and health-related quality-of-life among infants with respiratory syncytial virus infection: A multi-country prospective cohort study in Europe
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Mao, Zhuxin, primary, Li, Xiao, additional, Dacosta-Urbieta, Ana, additional, Billard, Marie-Noëlle, additional, Wildenbeest, Joanne, additional, Korsten, Koos, additional, Martinón-Torres, Federico, additional, Heikkinen, Terho, additional, Cunningham, Steve, additional, Snape, Matthew D., additional, Robinson, Hannah, additional, Pollard, Andrew J., additional, Postma, Maarten, additional, Dervaux, Benoit, additional, Hens, Niel, additional, Bont, Louis, additional, Bilcke, Joke, additional, and Beutels, Philippe, additional
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- 2023
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5. Comment on Transient Tachypnea of the Newborn Is Associated With an Increased Risk of Hospitalization Due to Respiratory Syncytial Virus Bronchiolitis
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van de Kam, Lieke W. P. C. G., Korsten, Koos, Wildenbeest, Joanne G., and Bont, Louis J.
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- 2019
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6. Contact With Young Children Increases the Risk of Respiratory Infection in Older Adults in Europe—the RESCEU Study
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Korsten, Koos, Adriaenssens, Niels, Coenen, Samuel, Butler, Chris C, Pirçon, Jean-Yves, Verheij, Theo J M, Bont, Louis J, Wildenbeest, Joanne G, Butler, Christopher, Verheij, Theo, Bont, Louis, Wildenbeest, Joanne, Nair, Harish, Campbell, Harry, Beutels, Philippe, Openshaw, Peter, Pollard, Andrew, Molero, Eva, Meijer, Adam, Fischer, Thea K, van den Berge, Maarten, Giaquinto, Carlo, Abram, Michael, Aerssens, Jeroen, Swanson, Kena, Gruselle, Olivier, Leach, Amanda, Stoszek, Sonia, Demont, Clarisse, Gallichan, Scott, Pavot, Vincent, Vernhes, Charlotte, Kumar, Veena, and RESCEU Investigators
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Europe ,Infectious Diseases ,Child, Preschool ,Odds Ratio ,Humans ,Infant ,Immunology and Allergy ,Human medicine ,Respiratory Tract Infections ,Biology ,Aged - Abstract
Background Knowledge about how older adults get a respiratory infection is crucial for planning preventive strategies. We aimed to determine how contact with young children living outside of the household affects the risk of acute respiratory tract infections (ARTI) in community-dwelling older adults. Methods This study is part of the European RESCEU older adult study. Weekly surveillance was performed to detect ARTI throughout 2 winter seasons (2017-2018, 2018-2019). Child exposure, defined as having regular contact with children under 5 living outside of the subject’s household, was assessed at baseline. The average attributable fraction was calculated to determine the fraction of ARTI explained by exposure to these children. Results We prospectively established that 597/1006 (59%) participants experienced at least 1 ARTI. Child exposure increased the risk of all-cause ARTI (adjusted odds ratio [aOR], 1.58; 95% confidence interval [CI], 1.21 -2.08; P = .001). This risk was highest in those with the most frequent contact (aOR, 1.80; 95% CI, 1.23-2.63; P = .003). The average attributable fraction of child exposure explaining ARTI was 10% (95% CI, 5%-15%). Conclusions One of 10 ARTI in community-dwelling older adults is attributable to exposure to preschool children living outside of the household. Clinical Trials Registration NCT03621930.
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- 2021
7. The burden of respiratory syncytial virus in healthy term-born infants in Europe: a prospective birth cohort study
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Wildenbeest, Joanne G, Billard, Marie-Noëlle, Zuurbier, Roy P, Korsten, Koos, Langedijk, Annefleur C, van de Ven, Peter M, Snape, Matthew D, Drysdale, Simon B, Pollard, Andrew J, Robinson, Hannah, Heikkinen, Terho, Cunningham, Steve, O'Neill, Thomas, Rizkalla, Bishoy, Dacosta-Urbieta, Ana, Martinón-Torres, Federico, van Houten, Marlies A, Bont, Louis J, Wildenbeest, Joanne, Billard, Marie-Noëlle, Zuurbier, Roy, Korsten, Koos, van Houten, Marlies, Langedijk, Annefleur, van de Ven, Peter, Bont, Louis, Drysdale, Simon, McGinley, Joseph, Lin, Gu-Lung, Snape, Matthew, Pollard, Andrew, Ives, Andrew, Wolfenden, Helen, Salgia, Sanjay, Shetty, Rohoth, Dacosta-Urbieta, Ana, Rivero-Calle, Irene, Gómez-Carballa, Alberto, Pischedda, Sara, Rodriguez-Tenreiro, Carmen, Martinón-Torres, Federico, Heikkinen, Terho, Cunningham, Steve, Nair, Harish, Campbell, Harry, O'Neill, Thomas, Miller, Margaret, Baggott, Julie, Beveridge, Catherine, McKernan, Rachael, Rizkalla, Bishoy, Beutels, Philippe, Openshaw, Peter, Meijer, Adam, Kølsen Fischer, Thea, van den Berge, Maarten, Giaquinto, Carlo, Abram, Michael, Swanson, Kena, Aerssens, Jeroen, Vernhes, Charlotte, Gallichan, Scott, Kumar, Veena, and Molero, Eva
- Abstract
Respiratory syncytial virus (RSV) is a major cause of hospitalisation in infants. The burden of RSV infection in healthy term infants has not yet been established. Accurate health-care burden data in healthy infants are necessary to determine RSV immunisation policy when RSV immunisation becomes available.
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- 2023
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8. The burden of respiratory syncytial virus in healthy term-born infants in Europe: a prospective birth cohort study
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Wildenbeest, Joanne G, primary, Billard, Marie-Noëlle, additional, Zuurbier, Roy P, additional, Korsten, Koos, additional, Langedijk, Annefleur C, additional, van de Ven, Peter M, additional, Snape, Matthew D, additional, Drysdale, Simon B, additional, Pollard, Andrew J, additional, Robinson, Hannah, additional, Heikkinen, Terho, additional, Cunningham, Steve, additional, O'Neill, Thomas, additional, Rizkalla, Bishoy, additional, Dacosta-Urbieta, Ana, additional, Martinón-Torres, Federico, additional, van Houten, Marlies A, additional, Bont, Louis J, additional, Wildenbeest, Joanne, additional, Zuurbier, Roy, additional, van Houten, Marlies, additional, Langedijk, Annefleur, additional, van de Ven, Peter, additional, Bont, Louis, additional, Drysdale, Simon, additional, McGinley, Joseph, additional, Lin, Gu-Lung, additional, Snape, Matthew, additional, Pollard, Andrew, additional, Ives, Andrew, additional, Wolfenden, Helen, additional, Salgia, Sanjay, additional, Shetty, Rohoth, additional, Rivero-Calle, Irene, additional, Gómez-Carballa, Alberto, additional, Pischedda, Sara, additional, Rodriguez-Tenreiro, Carmen, additional, Nair, Harish, additional, Campbell, Harry, additional, Miller, Margaret, additional, Baggott, Julie, additional, Beveridge, Catherine, additional, McKernan, Rachael, additional, Beutels, Philippe, additional, Openshaw, Peter, additional, Meijer, Adam, additional, Kølsen Fischer, Thea, additional, van den Berge, Maarten, additional, Giaquinto, Carlo, additional, Abram, Michael, additional, Swanson, Kena, additional, Aerssens, Jeroen, additional, Vernhes, Charlotte, additional, Gallichan, Scott, additional, Kumar, Veena, additional, and Molero, Eva, additional
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- 2022
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9. Coccidioidomycosis presenting years after returning from travel
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Korsten, Koos, Altenburg, Josje, Gittelbauer, Marieke, van Hengel, Peter, Jansen, Rogier, and van Dijk, Karin
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- 2024
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10. World Health Organization influenza-like illness underestimates the burden of respiratory syncytial virus infection in community-dwelling older adults
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Korsten, Koos, Adriaenssens, Niels, Coenen, Samuel, Butler, Chris C, Verheij, Theo J M, Bont, Louis J, Wildenbeest, Joanne G, Butler, Christopher, Verheij, Theo, Bont, Louis, Wildenbeest, Joanne, Nair, Harish, Campbell, Harry, Cunningham, Steve, Beutels, Philippe, Openshaw, Peter, Pollard, Andrew, Molero, Eva, Meijer, Adam, Martinon-Torres, Federico, Heikkinen, Terho, Fischer, Thea K, van den Berge, Maarten, Giaquinto, Carlo, Abram, Michael, Öner, Deniz, Aerssens, Jeroen, Swanson, Kena, Leach, Amanda, Stoszek, Sonia, Demont, Clarisse, Gallichan, Scott, Kumar, Veena, Falsey, Ann, and RESCEU Investigators
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Fever ,Infant ,virus diseases ,Respiratory Syncytial Virus Infections ,World Health Organization ,Cohort Studies ,Infectious Diseases ,Virus Diseases ,Respiratory Syncytial Virus, Human ,Influenza, Human ,Humans ,Immunology and Allergy ,Independent Living ,Prospective Studies ,Human medicine ,Respiratory Tract Infections ,Biology ,Aged - Abstract
Background Respiratory syncytial virus (RSV) surveillance is heavily dependent on the influenza-like illness (ILI) case definition from the World Health Organization (WHO). Because ILI includes fever in its syndromic case definition, its ability to accurately identify acute respiratory tract infections (ARTI) caused by RSV in older adults is uncertain. Methods The accuracy of the WHO ILI and a modified ILI (requiring only self-reported fever) case definitions in identifying patients with PCR-confirmed RSV-ARTI was evaluated in community-dwelling older adults (≥60 years) from the prospective European RESCEU cohort study. Results Among 1040 participants, 750 ARTI episodes were analyzed including 36 confirmed RSV-ARTI. Due to a general lack of fever, sensitivity for RSV-ARTI was 33% for modified ILI and 11% for ILI. The area under the curve for both ILI definitions was 0.52 indicating poor discrimination for RSV. RSV-ARTI could not be distinguished from all other ARTI based on clinical symptoms. Conclusions The use of ILI underestimated the occurrence of RSV-ARTI in community-dwelling older adults up to 9-fold (11% sensitivity). Because worldwide RSV surveillance depends largely on ILI, there is an urgent need for a better approach to measure the occurrence of RSV disease and the impact of future RSV vaccine introduction. Clinical Trials Registration. NCT03621930.
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- 2022
11. Low Sensitivity of BinaxNOW RSV in Infants
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Zuurbier, Roy P, Bont, Louis J, Langedijk, Annefleur C, Hamer, Mirjam, Korsten, Koos, Drysdale, Simon B, Snape, Matthew D, Robinson, Hannah, Pollard, Andrew J, Martinón-Torres, Federico, Rodríguez-Tenreiro Sánchez, Carmen, Gómez-Carballa, Alberto, Dacosta-Urbieta, Ana Isabel, Heikkinen, Terho, Cunningham, Steve, van Houten, Marlies A, Wildenbeest, Joanne G, Zuurbier, Roy, Bont, Louis, Langedijk, Annefleur, van Houten, Marlies, Wildenbeest, Joanne, Drysdale, Simon, Snape, Matthew, Pollard, Andrew, Dacosta-Urbieta, Ana, Nair, Harish, Campbell, Harry, Openshaw, Peter, Beutels, Philippe, Molero, Eva, Meijer, Adam, Kølsen Fischer, Thea, van den Berge, Maarten, Giaquinto, Carlo, Esser, Mark, Knirsch, Charles, Leach, Amanda, Gallichan, Scott, Aerssens, Jeroen, Rosen, Brian, and Investigators, RESCEU
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Male ,medicine.medical_specialty ,Adolescent ,medicine.drug_class ,Point-of-Care Systems ,Point-of-care testing ,Antibiotics ,Respiratory Syncytial Virus Infections ,Sensitivity and Specificity ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Severity of illness ,medicine ,Humans ,Immunology and Allergy ,030212 general & internal medicine ,Pathology, Molecular ,Respiratory system ,Child ,Antigens, Viral ,Reference standards ,0303 health sciences ,Respiratory tract infections ,030306 microbiology ,business.industry ,Gold standard (test) ,Confidence interval ,3. Good health ,Hospitalization ,Infectious Diseases ,Case-Control Studies ,Child, Preschool ,Respiratory Syncytial Virus, Human ,Female ,Reagent Kits, Diagnostic ,business - Abstract
Background Respiratory syncytial virus (RSV) is a major cause of hospitalization in infants. Early detection of RSV can optimize clinical management and minimize use of antibiotics. BinaxNOW RSV (BN) is a rapid antigen detection test that is widely used. We aimed to validate the sensitivity of BN in hospitalized and nonhospitalized infants against the gold standard of molecular diagnosis. Methods We evaluated the performance of BN in infants with acute respiratory tract infections with different degrees of disease severity. Diagnostic accuracy of BN test results were compared with molecular diagnosis as reference standard. Results One hundred sixty-two respiratory samples from 148 children from October 2017 to February 2019 were studied. Sixty-six (40.7%) samples tested positive for RSV (30 hospitalizations, 31 medically attended episodes not requiring hospitalization, and 5 nonmedically attended episodes). Five of these samples tested positive with BN, leading to an overall sensitivity of BN of 7.6% (95% confidence interval [CI], 3.3%–16.5%) and a specificity of 100% (95% CI, 96.2%–100%). Sensitivity was low in all subgroups. Conclusions We found a low sensitivity of BN for point-of-care detection of RSV infection. BinaxNOW RSV should be used and interpreted with caution.
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- 2020
12. Operative or conservative treatment in patients with Rockwood type III acromioclavicular dislocation: a systematic review and update of current literature
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Korsten, Koos, Gunning, Amy C., and Leenen, Luke P. H.
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- 2014
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13. Respiratory syncytial virus infections on both ends of the age spectrum
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Korsten Koos, Bont, L.J., Wildenbeest, J.G., and University Utrecht
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business.industry ,Respiratory infection ,Medicine ,Respiratory system ,business ,Virology ,RSV ,Respiratory Syncytial Virus ,Older Adults ,Disease burden ,Virus - Abstract
During my PhD I have looked at disease caused by the respiratory syncytial virus (RSV) in both children and older adults. In children we updated a prediction tool which can identify children at higher risk of severe infection in the first year of life. Next I have looked at the development of asthmatic symptoms such as wheeze in childhood following severe RSV infection in early life. We found that RSV is an independent risk factor for wheezing illness in those without atopic disease but not in those with an atopic constitution. Furthermore, I investigated the agreement between the many surrogates of asthmatic disease that are used interchangeably to define asthma in children. We observed that there is major disagreement between definitions and advise caution in head-to-head comparison. In the second part of my thesis described the incidence and disease burden of RSV in community-dwelling older adults (adults ≥60 years living independently at home). In a large European prospective cohort we observed that RSV is prevalent in community-dwelling older adults but rarely causes severe disease. This suggests that watchful waiting, using a continuity of care approach to identify those who do need more intensive care is often justified when RSV is suspected in family practice. We also observed that exposure to young children may play an important role in the occurrence of respiratory infection in older adults. Last, we observed that worldwide surveillance programs may not detect RSV infection if they use the influenza-like-illness (ILI) case definition because it does not match the clinical symptoms often seen in RSV.
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- 2021
14. Performance Assessment of a Rapid Molecular Respiratory Syncytial Virus Point-of-Care Test: A Prospective Community Study in Older Adults.
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Zuurbier, Roy P, Korsten, Koos, Verheij, Theo J M, Butler, Chris, Adriaenssens, Niels, Coenen, Samuel, Gruselle, Olivier, Vantomme, Valerie, Houten, Marlies A van, Bont, Louis J, Wildenbeest, Joanne G, Investigators, REspiratory Syncytial Virus Consortium in EUrope (RESCEU), van Houten, Marlies A, and REspiratory Syncytial Virus Consortium in EUrope (RESCEU) Investigators
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INFLUENZA diagnosis , *RESPIRATORY syncytial virus , *INFLUENZA A virus , *MOLECULAR diagnosis , *NASOPHARYNX , *INFLUENZA B virus , *RESPIRATORY syncytial virus infections , *SENSITIVITY & specificity (Statistics) , *LONGITUDINAL method - Abstract
Background: Respiratory syncytial virus (RSV) causes a substantial burden in older adults. Viral load in RSV-infected adults is generally lower compared to young children, which could result in suboptimal sensitivity of RSV diagnostics. Although the Xpert® Xpress Flu/RSV assay has been used in routine clinical care, its sensitivity to diagnose RSV infection in older adults is largely unknown. We aimed to compare the performance of the Xpert® Xpress Flu/RSV assay with real-time reverse-transcription polymerase chain reaction (RT-PCR) in home-dwelling older adults (≥60 years of age).Methods: Nasopharyngeal swabs were tested with Xpert® Xpress Flu/RSV and compared to RSV RT-PCR in older adults with acute respiratory tract infections with different levels of disease severity.Results: We studied 758 respiratory samples from 561 older adults from 2 consecutive RSV seasons. Thirty-five (4.6%) samples tested positive for RSV by at least 1 of the assays, of which 2 samples were negative by Xpert® Xpress Flu/RSV and 3 samples by real-time RT-PCR. The positive percentage agreement (PPA) was 90.9% (95% confidence interval [CI], 76.4%-96.8%) and negative percentage agreement was 99.7% (95% CI, 99.0%-99.9%). Viral loads were low (≤103 copies/mL or cycle threshold value ≥34) in all cases with discordant results for the 2 assays.Conclusions: The PPA of Xpert® Xpress Flu/RSV compared to routine RT-PCR is high for RSV detection in home-dwelling older adults. The assay is fast and easy to use at the point of care.Clinical Trials Registration: NCT03621930. [ABSTRACT FROM AUTHOR]- Published
- 2022
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15. Contact With Young Children Increases the Risk of Respiratory Infection in Older Adults in Europe-the RESCEU Study.
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Korsten, Koos, Adriaenssens, Niels, Coenen, Samuel, Butler, Chris C, Pirçon, Jean Yves, Verheij, Theo J M, Bont, Louis J, Wildenbeest, Joanne G, Investigators, RESCEU, and RESCEU Investigators
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RESPIRATORY infections , *RESEARCH funding , *ODDS ratio - Abstract
Background: Knowledge about how older adults get a respiratory infection is crucial for planning preventive strategies. We aimed to determine how contact with young children living outside of the household affects the risk of acute respiratory tract infections (ARTI) in community-dwelling older adults.Methods: This study is part of the European RESCEU older adult study. Weekly surveillance was performed to detect ARTI throughout 2 winter seasons (2017-2018, 2018-2019). Child exposure, defined as having regular contact with children under 5 living outside of the subject's household, was assessed at baseline. The average attributable fraction was calculated to determine the fraction of ARTI explained by exposure to these children.Results: We prospectively established that 597/1006 (59%) participants experienced at least 1 ARTI. Child exposure increased the risk of all-cause ARTI (adjusted odds ratio [aOR], 1.58; 95% confidence interval [CI], 1.21 -2.08; P = .001). This risk was highest in those with the most frequent contact (aOR, 1.80; 95% CI, 1.23-2.63; P = .003). The average attributable fraction of child exposure explaining ARTI was 10% (95% CI, 5%-15%).Conclusions: One of 10 ARTI in community-dwelling older adults is attributable to exposure to preschool children living outside of the household.Clinical Trials Registration: NCT03621930. [ABSTRACT FROM AUTHOR]- Published
- 2022
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16. Respiratory Syncytial Virus Consortium in Europe (RESCEU) Birth Cohort Study: Defining the Burden of Infant Respiratory Syncytial Virus Disease in Europe
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Wildenbeest, Joanne G, Zuurbier, Roy P, Korsten, Koos, van Houten, Marlies A, Billard, Marie N, Derksen-Lazet, Nicole, Snape, Matthew D, Drysdale, Simon B, Robinson, Hannah, Pollard, Andrew J, Heikkinen, Terho, Cunningham, Steve, Leach, Amanda, Martinón-Torres, Federico, Rodríguez-Tenreiro Sánchez, Carmen, Gómez-Carballa, Alberto, Bont, Louis J, Wildenbeest, Joanne, Zuurbier, Roy, van Houten, Marlies, Billard, Marie, Bont, Louis, Drysdale, Simon, Snape, Matthew, Pollard, Andrew, Sánchez, Carmen Rodríguez-Tenreiro, Nair, Harish, Campbell, Harry, Openshaw, Peter, Beutels, Philippe, Molero, Eva, Meijer, Adam, Sanders, Elisabeth, Fischer, Thea Kølsen, van den Berge, Maarten, Giaquinto, Carlo, Esser, Mark, Knirsch, Charles, Gallichan, Scott, Aerssens, Jeroen, and Rosen, Brian
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Pediatrics ,medicine.medical_specialty ,viruses ,Respiratory Syncytial Virus Infections ,Disease ,Virus ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,030225 pediatrics ,Respiratory Syncytial Virus Vaccines ,Humans ,Immunology and Allergy ,Medicine ,Prospective Studies ,030212 general & internal medicine ,Respiratory system ,Prospective cohort study ,Respiratory Tract Infections ,Acute respiratory tract infection ,Cardiopulmonary disease ,business.industry ,Incidence ,Infant ,3. Good health ,Europe ,Hospitalization ,Clinical trial ,Infectious Diseases ,Respiratory Syncytial Virus, Human ,Cohort ,business ,Biomarkers - Abstract
BackgroundRespiratory syncytial virus (RSV) causes significant morbidity and mortality in infants worldwide. Although prematurity and cardiopulmonary disease are risk factors for severe disease, the majority of infants hospitalized with RSV are previously healthy. Various vaccines and therapeutics are under development and expected to be available in the near future. To inform the use of these new vaccines and therapeutics, it is necessary to determine the burden of RSV disease in Europe. We will prospectively follow-up a birth cohort to obtain incidence data on RSV acute respiratory tract infection (ARTI).MethodsMulticenter prospective study of a birth cohort consisting of 10 000 healthy infants, recruited during 3 consecutive years. RSV associated hospitalization in the first year of life will be determined by questionnaires and hospital chart reviews. A nested cohort of 1000 infants will be actively followed. In case of ARTI, a respiratory sample will be collected for RSV molecular diagnosis.ResultsThe primary outcome is the incidence rate of RSV-associated hospitalization in the first year of life. In the active cohort the primary outcome is RSV associated ARTI and MA-ARTI.ConclusionsWe will provide key information to fill the gaps in knowledge about the burden of RSV disease in healthy infants.Clinical Trials RegistrationNCT03627572.
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- 2020
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17. Burden of respiratory syncytial virus infection in community-dwelling older adults in Europe (RESCEU): an international prospective cohort study
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Korsten, Koos, primary, Adriaenssens, Niels, additional, Coenen, Samuel, additional, Butler, Christopher, additional, Ravanfar, Behnaz, additional, Rutter, Heather, additional, Allen, Julie, additional, Falsey, Ann, additional, Pirçon, Jean-Yves, additional, Gruselle, Olivier, additional, Pavot, Vincent, additional, Vernhes, Charlotte, additional, Balla-Jhagjhoorsingh, Sunita, additional, Öner, Deniz, additional, Ispas, Gabriela, additional, Aerssens, Jeroen, additional, Shinde, Vivek, additional, Verheij, Theo, additional, Bont, Louis, additional, and Wildenbeest, Joanne, additional
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- 2020
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18. Defining asthma in children: how well do parents, doctors and spirometry agree?
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Korsten, Koos, primary, Naaktgeboren, Christiana A., additional, Bont, Louis J., additional, van der Ent, Cornelis K., additional, and de Hoog, Marieke L.A., additional
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- 2020
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19. Sustained Cellular and Humoral Immune Responses From an Adenoviral Vector-based Respiratory Syncytial Virus Vaccine
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Korsten, Koos, primary and Bont, Louis J, additional
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- 2019
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20. Seasonal immunisation against respiratory syncytial virus disease
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Korsten, Koos and Bont, Louis
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Public Health, Environmental and Occupational Health - Published
- 2017
21. Population-Attributable Risk of Risk Factors for Recurrent Wheezing in Moderate Preterm Infants During the First Year of Life
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Blanken, Maarten O, Korsten, Koos, Achten, Niek B, Tamminga, Saskia, Nibbelke, Elisabeth E, Sanders, Elisabeth A M, Smit, Henriette A, Groenwold, Rolf H H, Bont, Louis, and Dutch RSV Neonatal Network
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population-attributable risk ,moderate preterm infants ,respiratorysyncytial virus ,recurrent wheezing ,Research Support, Non-U.S. Gov't ,Journal Article ,day-care attendance - Abstract
BACKGROUND: Recurrent wheezing in young infants has a high prevalence, influences quality of life, and generates substantial health care costs. We previously showed that respiratory syncytial virus infection is an important mechanism of recurrent wheezing in moderate preterm infants. We aimed to provide population-attributable risks (PAR) of risk factors for recurrent wheezing during the first year of life in otherwise healthy moderate preterm infants. METHODS: RISK is a multicentre prospective birth cohort study of 4424 moderate preterm infants born at 32-35 weeks gestation. We estimated PAR of risk factors for recurrent wheezing, which was defined as three or more parent-reported wheezing episodes during the first year of life. RESULTS: We evaluated 3952 (89%) children at 1 year of age, of whom 705 infants (18%) developed recurrent wheezing. Fourteen variables were independently associated with recurrent wheezing. Hospitalisation for respiratory syncytial virus bronchiolitis had a strong relationship with recurrent wheezing (RR 2.6; 95% confidence interval, CI, 2.2, 3.1), but a relative modest PAR (8%; 95% CI 6, 11%) which can be explained by a low prevalence (13%). Day-care attendance showed a strong relationship with recurrent wheezing (RR 1.9; 95% CI 1.7, 2.2) and the highest PAR (32%; 95% CI 23, 37%) due to a high prevalence (67%). The combined adjusted PAR for the 14 risk factors associated with recurrent wheezing was 49% (95% CI 46, 52%). CONCLUSIONS: In moderate preterm infants, day-care attendance has the largest PAR for recurrent wheezing. Trial evidence is needed to determine the potential benefit of delayed day-care attendance in this population.
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- 2016
22. Prediction model of RSV-hospitalization in late preterm infants : An update and validation study
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Korsten, Koos, Blanken, Maarten O, Nibbelke, Elisabeth E, Moons, Karel G M, Bont, Louis, and Dutch RSV Neonatal Network
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Late preterm ,Research Support, Non-U.S. Gov't ,Validation ,Journal Article ,Validation Studies ,Respiratory syncytial virus ,Prediction ,Updating - Abstract
BACKGROUND: New vaccines and RSV therapeutics have been developed in the past decade. With approval of these new pharmaceuticals on the horizon, new challenges lie ahead in selecting the appropriate target population. We aimed to improve a previously published prediction model for prediction of RSV-hospitalization within the first year of life. METHODS: Two consecutive prospective multicenter birth cohort studies were performed from June 2008 until February 2015. The first cohort (RISK-I, n=2524, 2008-2011) was used to update the existing model. The updated model was subsequently validated in the RISK-II cohort (n=1564, 2011-2015). We used the TRIPOD criteria for transparent reporting. RESULTS: 181 infants (n=127 in RISK-I, n=54 in RISK-II) were hospitalized for RSV within their first year of life. The updated model included the following predictors; day care attendance and/or siblings (OR: 5.3; 95% CI 2.8-10.1), birth between Aug. 14th and Dec. 1st (OR: 2.4; 1.8-3.2), neonatal respiratory support (OR 2.2; 1.6-3.0), breastfeeding ≤4months (OR 1.6; 1.2-2.2) and maternal atopic constitution (OR 1.5; 1.1-2.1). The updated models' discrimination was superior to the original model in the RISK-II cohort (AUROC 0.72 95% CI 0.65-0.78 versus AUROC 0.66, 95% CI 0.60-0.73, respectively). The updated model was translated into a simple nomogram to be able to distinguish infants with high versus low risk of RSV-hospitalization. CONCLUSION: We developed and validated a clinical prediction model to be able to predict RSV-hospitalization in preterm infants born within 32-35weeks gestational age. A simple nomogram was developed to target RSV therapeutics to those children who will benefit the most.
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- 2016
23. Prediction model of RSV-hospitalization in late preterm infants: An update and validation study
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Korsten, Koos, primary, Blanken, Maarten O., additional, Nibbelke, Elisabeth E., additional, Moons, Karel G.M., additional, and Bont, Louis, additional
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- 2016
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24. Cesarean Section and Hospitalization for Respiratory Syncytial Virus Infection
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Achten, Niek B., primary, Korsten, Koos, additional, Blanken, Maarten O., additional, Nibbelke, Elisabeth E., additional, and Bont, Louis, additional
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- 2015
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25. Operative or conservative treatment in patients with Rockwood type III acromioclavicular dislocation: a systematic review and update of current literature
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Korsten, Koos, primary, Gunning, Amy C., additional, and Leenen, Luke P. H., additional
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- 2013
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26. Population-Attributable Risk of Risk Factors for Recurrent Wheezing in Moderate Preterm Infants During the First Year of Life.
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Blanken, Maarten O., Korsten, Koos, Achten, Niek B., Tamminga, Saskia, Nibbelke, Elisabeth E., Sanders, Elisabeth A.M., Smit, Henriette A., Groenwold, Rolf H.H., Bont, Louis, Breukels, M.A., Pestman‐Harms, M.M., Westra, M., Adeel, A.O.A., Verhallen, J.T.C.M., vanZoest, J.G.C.M., Rijk‐van Gent, H., tenTusscher, G.W., Hoffman‐van der Meer, A.E., Smeets, C.C.J.M., and vanLeer, E.H.G.
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- *
POPULATION , *WHEEZE , *PREMATURE infants , *QUALITY of life , *COHORT analysis , *COMPARATIVE studies , *COST effectiveness , *HOSPITAL care , *PREMATURE infant diseases , *LONGITUDINAL method , *RESEARCH methodology , *MEDICAL cooperation , *RESEARCH , *RESPIRATORY organ sounds , *BRONCHIOLE diseases , *DISEASE relapse , *EVALUATION research , *RESPIRATORY syncytial virus infections , *ECONOMICS - Abstract
Background: Recurrent wheezing in young infants has a high prevalence, influences quality of life, and generates substantial health care costs. We previously showed that respiratory syncytial virus infection is an important mechanism of recurrent wheezing in moderate preterm infants. We aimed to provide population-attributable risks (PAR) of risk factors for recurrent wheezing during the first year of life in otherwise healthy moderate preterm infants.Methods: RISK is a multicentre prospective birth cohort study of 4424 moderate preterm infants born at 32-35 weeks gestation. We estimated PAR of risk factors for recurrent wheezing, which was defined as three or more parent-reported wheezing episodes during the first year of life.Results: We evaluated 3952 (89%) children at 1 year of age, of whom 705 infants (18%) developed recurrent wheezing. Fourteen variables were independently associated with recurrent wheezing. Hospitalisation for respiratory syncytial virus bronchiolitis had a strong relationship with recurrent wheezing (RR 2.6; 95% confidence interval, CI, 2.2, 3.1), but a relative modest PAR (8%; 95% CI 6, 11%) which can be explained by a low prevalence (13%). Day-care attendance showed a strong relationship with recurrent wheezing (RR 1.9; 95% CI 1.7, 2.2) and the highest PAR (32%; 95% CI 23, 37%) due to a high prevalence (67%). The combined adjusted PAR for the 14 risk factors associated with recurrent wheezing was 49% (95% CI 46, 52%).Conclusions: In moderate preterm infants, day-care attendance has the largest PAR for recurrent wheezing. Trial evidence is needed to determine the potential benefit of delayed day-care attendance in this population. [ABSTRACT FROM AUTHOR]- Published
- 2016
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27. Sustained Cellular and Humoral Immune Responses From an Adenoviral Vector-based Respiratory Syncytial Virus Vaccine.
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Korsten, Koos and Bont, Louis J.
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- 2020
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28. Performance Assessment of a Rapid Molecular Respiratory Syncytial Virus Point-of-Care Test: A Prospective Community Study in Older Adults
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Zuurbier, Roy P, Korsten, Koos, Verheij, Theo J M, Butler, Chris, Adriaenssens, Niels, Coenen, Samuel, Gruselle, Olivier, Vantomme, Valerie, van Houten, Marlies A, Bont, Louis J, Wildenbeest, Joanne G, Zuurbier, Roy, Verheij, Theo, van Houten, Marlies, Bont, Louis, Wildenbeest, Joanne, Butler, Christopher, Pollard, Andrew, Leach, Amanda, Nair, Harish, Campbell, Harry, Beutels, Philippe, Openshaw, Peter, Martinon-Torres, Federico, Heikkinen, Terho, Meijer, Adam, Fischer, Thea Kølsen, van den Berge, Maarten, Giaquinto, Carlo, Abram, Michael, Swanson, Kena, Aerssens, Jeroen, Demont, Clarisse, Gallichan, Scott, Rosen, Brian, Molero, Eva, and REsp Syncytial Virus Consortium EU (RESCEU)
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viruses ,virus diseases ,Respiratory Syncytial Virus Infections ,respiratory system ,Sensitivity and Specificity ,Influenza B virus ,Infectious Diseases ,Molecular Diagnostic Techniques ,Influenza A virus ,Point-of-Care Testing ,Child, Preschool ,Nasopharynx ,Respiratory Syncytial Virus, Human ,Influenza, Human ,Immunology and Allergy ,Humans ,Human medicine ,Prospective Studies ,Child ,Biology ,Aged - Abstract
Background Respiratory syncytial virus (RSV) causes a substantial burden in older adults. Viral load in RSV-infected adults is generally lower compared to young children, which could result in suboptimal sensitivity of RSV diagnostics. Although the Xpert® Xpress Flu/RSV assay has been used in routine clinical care, its sensitivity to diagnose RSV infection in older adults is largely unknown. We aimed to compare the performance of the Xpert® Xpress Flu/RSV assay with real-time reverse-transcription polymerase chain reaction (RT-PCR) in home-dwelling older adults (≥60 years of age). Methods Nasopharyngeal swabs were tested with Xpert® Xpress Flu/RSV and compared to RSV RT-PCR in older adults with acute respiratory tract infections with different levels of disease severity. Results We studied 758 respiratory samples from 561 older adults from 2 consecutive RSV seasons. Thirty-five (4.6%) samples tested positive for RSV by at least 1 of the assays, of which 2 samples were negative by Xpert® Xpress Flu/RSV and 3 samples by real-time RT-PCR. The positive percentage agreement (PPA) was 90.9% (95% confidence interval [CI], 76.4%–96.8%) and negative percentage agreement was 99.7% (95% CI, 99.0%–99.9%). Viral loads were low (≤103 copies/mL or cycle threshold value ≥34) in all cases with discordant results for the 2 assays. Conclusions The PPA of Xpert® Xpress Flu/RSV compared to routine RT-PCR is high for RSV detection in home-dwelling older adults. The assay is fast and easy to use at the point of care. Clinical Trials Registration NCT03621930.
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29. Coccidioidomycosis presenting years after returning from travel.
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Korsten K, Altenburg J, Gittelbauer M, van Hengel P, Jansen R, and van Dijk K
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After having traveled to California in 2017, a 26-year old Dutch man presented in 2020 with persisting cough and shortness of breath. Radiology showed cystic bronchiectasis with peri-bronchial consolidation in his right upper lobe. Laboratory studies in August 2021 showed an increased total IgE, specific Aspergillus IgE, eosinophilia and positive BAL culture for Coccidioides immitis/posadasii . After 6 weeks of itraconazole treatment for suspected allergic bronchopulmonary aspergillosis, symptoms persisted and respiratory cultures remained positive. The infection was cleared after a 6-month course of fluconazole. (max 75 words)., (© 2024 The Authors. Published by Elsevier B.V. on behalf of International Society for Human and Animal Mycology.)
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- 2023
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30. Burden of respiratory syncytial virus infection in community-dwelling older adults in Europe (RESCEU): an international prospective cohort study.
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Korsten K, Adriaenssens N, Coenen S, Butler C, Ravanfar B, Rutter H, Allen J, Falsey A, Pirçon JY, Gruselle O, Pavot V, Vernhes C, Balla-Jhagjhoorsingh S, Öner D, Ispas G, Aerssens J, Shinde V, Verheij T, Bont L, and Wildenbeest J
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- Aged, Aged, 80 and over, Europe epidemiology, Hospitalization, Humans, Independent Living, Infant, Middle Aged, Prospective Studies, Risk Factors, Respiratory Syncytial Virus Infections epidemiology, Respiratory Syncytial Virus, Human
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Background: Respiratory syncytial virus (RSV) infection in older adults is recognised as an important health issue. We aimed to assess the community burden of RSV in Europe in older adults aged ≥60 years., Methods: This international, prospective, observational cohort study is part of work by the REspiratory Syncytial virus Consortium in EUrope (RESCEU). Participants were recruited through general practitioners' (GPs) offices before two independent RSV seasons. Participants reported weekly about symptoms of acute respiratory tract infection (ARTI) during one RSV season. ARTI patients were tested for RSV during home visits and completed a daily symptom diary. RSV illness included PCR-confirmed ARTI and those showing seroconversion over the season. RSV ARTI was based on PCR alone (ClinicalTrials.gov, NCT03621930)., Results: We recruited 1040 participants (527 in season 2017-2018 and 513 in season 2018-2019) with a median age of 75 years (range 60-100 years). Of these, 1023 (99%) lived independently at home at baseline. RSV illness incidence was 22 out of 527 (4.2%) and 37 out of 513 (7.2%) in the respective seasons. RSV illness did not affect frailty or cardiopulmonary status during the course of the study. No patients were hospitalised or died from RSV illness. In the 36 patients with PCR confirmed RSV ARTI, symptom duration averaged 19 days, while a doctor's visit took place in 11 out of 36 cases (31%). RSV ARTI could not be differentiated clinically from all other ARTIs based on symptoms., Conclusion: This European study showed that RSV is prevalent in community-dwelling older adults and rarely causes severe disease. This suggests that watchful waiting, using a continuity of care approach to identify those who do need more intensive care, is often justified when RSV is suspected in family practice., Competing Interests: Conflict of interest: K. Korsten has nothing to disclose. Conflict of interest: N. Adriaenssens has nothing to disclose. Conflict of interest: S. Coenen reports grants and non-financial support from European Union (EU) Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA) Innovative Medicines Initiative 2 (IMI-2) Joint Undertaking (grant: 116019), during the conduct of the study. Conflict of interest: C. Butler reports grants from the National Institute for Health Research (NIHR) (as NIHR Senior Investigator), grants from the EU Horizon 2020 programme to support the study, grants from the NIHR Health Protection Research Unit on Health Care Associated Infections and Antimicrobial Resistance, grants from the NIHR Health for the MedTech and In Vitro Diagnostics Cooperative for innovative diagnostics and monitoring technology to enhance community healthcare, during the conduct of the study; personal fees for advisory board work from Pfizer and Roche Molecular Systems; and grants from Roche Molecular Diagnostics. Conflict of interest: B. Ravanfar has nothing to disclose. Conflict of interest: H. Rutter has nothing to disclose. Conflict of interest: J. Allen has nothing to disclose. Conflict of interest: A. Falsey reports grants from Janssen, Merck, Sharpe and Dohme, and Pfizer, as well as non-financial support for meeting attendance from Sanofi Pasteur, outside the submitted work. Conflict of interest: J-Y. Pirçon is an employee of GlaxoSmithKline Vaccines. Conflict of interest: O. Gruselle is an employee of GlaxoSmithKline. Conflict of interest: V. Pavot is an employee of Sanofi Pasteur. Conflict of interest: C. Vernhes is an employee of Sanofi Pasteur. Conflict of interest: S. Balla-Jhagjhoorsingh is an employee of Janssen Vaccines & Prevention. Conflict of interest: D. Öner is an employee of Janssen Pharmaceutica NV and reports grants from the IMI-2 Joint Undertaking (grant: 116019), during the conduct of the study. Conflict of interest: G. Ispas is an employee of Janssen Pharmaceutica NV. Conflict of interest: J. Aerssens is an employee of Janssen Pharmaceutica NV. Conflict of interest: V. Shinde has nothing to disclose. Conflict of interest: T. Verheij reports grants from Janssen Pharmaceuticals, Becton Dickinson, Abbott and Biomerieux, outside the submitted work. Conflict of interest: L. Bont has regular interaction with pharmaceutical and other industrial partners. He has not received personal fees or other personal benefits; however, University Medical Center Utrecht has received major funding for investigator-initiated studies from AbbVie, MedImmune, Janssen, the Bill and Melinda Gates Foundation, Nutricia (Danone) and MeMed Diagnostics; has received major cash or in kind funding as part of the public–private partnership, IMI-2 funded REspiratory Syncytial virus Consortium in EUrope (RESCEU) project from GlaxoSmithKline, Novavax, Janssen, AstraZeneca, Pfizer and Sanofi; has received major funding from Julius Clinical for participating in the INFORM study sponsored by MedImmune; has received minor funding for participation in trials by Regeneron and Janssen from 2015–2017; and has received minor funding for consultation and invited lectures by AbbVie, MedImmune, Ablynx, Bavaria Nordic, MabXience, Novavax, Pfizer and Janssen. L. Bont is also the founding chairman of the ReSViNET Foundation. Conflict of interest: J. Wildenbeest has nothing to disclose., (Copyright © ERS 2021.)
- Published
- 2021
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