8 results on '"Kostadinova, I. I."'
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2. Harmonizing and improving European education in prescribing: An overview of digital educational resources used in clinical pharmacology and therapeutics
- Author
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Bakkum, Michiel J., Tichelaar, Jelle, Papaioannidou, Paraskevi, Likic, Robert, Sanz Alvarez, Emilio J., Christiaens, Thierry, Costa, João N., Mačiulaitis, Romaldas, Dima, Lorena, Coleman, Jamie, Richir, Milan C., Agtmael, Michiel A., Atanasova, Ivanka, Ganeva, Maria, Gatchev, Emil, Kostadinova, I. I., Mimica Matanovic, S., Vitezic, D, Greta, Wozniak, Kmonickova, E., Karel, Urbanek, Damkier, P., Huupponen, R. K., Auffret, Marine, Bejan‐ Angoulvant, T., Laurent, Chouchana, Jean‐Luc, Cracowski, Drici, M. D., Faillie, J. L., Hélène, Geniaux, Molimard, M., Orlikowski, D., Palin, Karine, Pers, Y.‐M., Picard, Nicolas, Simon, N., Toussirot, E., Boger, R. H., Cascorbi, I., Mueller, S. C., Regenthal, R., Schwab, M., Schwaninger, M. S., Thuermann, P. A., Wojnowski, L., Kouvelas, D., Riba, P., Kerins, David M., Williams, David J., Cosentino, M., De Ponti, Fabrizio, Filippelli, Amelia, Leone, R., Locatelli, Vittorio, Jansone, Baiba, Gulbinovic, Romaldas, Mifsud, Janet, Braszko Jan, J., Kocic, I., Luiza, Breitenfeld, Castelo‐Branco, M., Simona, Conea, Ioan, Magyar, Bevc, S., Mojca, Krzan, Bernal, M. L., Capellà, D., Carcas, A., De Abajo, F. J., Lopez‐Rico, M., Lucena, M. I., Pontes, C., Sanz, E. J., Böttiger, Y., Le Grevès, Madeleine, Waard‐Siebinga, I., Janssen Ben, J. A., Wilma, Knol, Rahul, Pandit, Rosse, F., Dent, G., Albert, Ferro, Hitchings, A. W., Kapil, V., Linton, K. D., Loke, Y. K., Michael, Okorie, David, Plumb Richard, Pontefract, Sarah, Ranmuthu, S., Sampson, A. P., Thanacoody, H. K. R., Whitfield Jonathan, P., Wilson, Kurt, for the Education Working Group of the European Association for Clinical Pharmacology and Therapeutics (EACPT) and its affiliated Network of Teachers in Pharmacotherapy (NOTIP), Bakkum, M, Tichelaar, J, Papaioannidou, P, Likic, R, Sanz Alvarez, E, Christiaens, T, Costa, J, Mačiulaitis, R, Dima, L, Coleman, J, Richir, M, van Agtmael, M, Locatelli, V, Internal medicine, Other Research, Bakkum M.J., Tichelaar J., Papaioannidou P., Likic R., Sanz Alvarez E.J., Christiaens T., Costa J.N., Maciulaitis R., Dima L., Coleman J., Richir M.C., van Agtmael M.A., Atanasova I., Ganeva M., Gatchev E., Kostadinova I.I., Mimica Matanovic S., Vitezic D., Greta W., Kmonickova E., Karel U., Damkier P., Huupponen R.K., Auffret M., Bejan-Angoulvant T., Laurent C., Jean-Luc C., Drici M.D., Faillie J.L., Helene G., Molimard M., Orlikowski D., Palin K., Pers Y.-M., Picard N., Simon N., Toussirot E., Boger R.H., Cascorbi I., Mueller S.C., Regenthal R., Schwab M., Schwaninger M.S., Thuermann P.A., Wojnowski L., Kouvelas D., Riba P., Kerins D.M., Williams D.J., Cosentino M., De Ponti F., Filippelli A., Leone R., Locatelli V., Jansone B., Gulbinovic R., Mifsud J., Braszko Jan J., Kocic I., Luiza B., Castelo-Branco M., Simona C., Ioan M., Bevc S., Mojca K., Bernal M.L., Capella D., Carcas A., De Abajo F.J., Lopez-Rico M., Lucena M.I., Pontes C., Bottiger Y., Le Greves M., de Waard-Siebinga I., Janssen Ben J.A., Wilma K., Rahul P., van Rosse F., Dent G., Albert F., Hitchings A.W., Kapil V., Linton K.D., Loke Y.K., Michael O., David P.R., Pontefract S., Ranmuthu S., Sampson A.P., Thanacoody H.K.R., Whitfield Jonathan P., and Wilson K.
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Computer-Assisted Instruction ,Harmonization ,030226 pharmacology & pharmacy ,law.invention ,open educational resource ,03 medical and health sciences ,0302 clinical medicine ,Medicaments -- Prescripció ,law ,clinical pharmacology and therapeutic ,Humans ,Learning ,Pharmacology (medical) ,Narrative ,030212 general & internal medicine ,Curriculum ,Schools, Medical ,Cross-Sectional Studie ,Pharmacology ,education ,Medical education ,Prescribing ,clinical pharmacology and therapeutics ,digital ,open educational resources ,Clinical pharmacology ,Drugs -- Prescribing ,Principal (computer security) ,Open educational resources ,Variety (cybernetics) ,Cross-Sectional Studies ,Pharmacology, Clinical ,Psychology ,Human - Abstract
CONTRIBUTORS IN THE NETWORK OF TEACHERS IN PHARMACOTHERAPY (NOTIP) (ALPHABETIZED BY COUNTRY): Atanasova, Ivanka (Sofia University St. Kliment Ohridski, Sofia, Bulgaria); Ganeva, Maria (Trakia University, Stara Zagora, Bulgaria); Gatchev, Emil (Medical University of Sofia, Sofia, Bulgaria); Kostadinova, II (Medical University Plovdiv, Plovdiv, Bulgaria); Mimica Matanovic, S (University of Osijek, Osijek, Croatia); Vitezic, D (University of Rijeka Medical School, Rijeka, Croatia); Wozniak, Greta (University of Cyprus, Nicosia, Cyprus); Kmonickova, E (Charles University, Pilsen, Czech Republic); Urbanek, Karel (Palacky University, Olomouc, Czech Republic); Damkier, P (University of Southern Denmark, Odense, Denmark); Huupponen, RK (University of Turku, Turku, Finland); Auffret, Marine (Hospices civils de Lyon, Lyon, France); Bejan-Angoulvant, T (Université de Tours, Tours, France); Chouchana, Laurent (Hospital Cochin, Paris, France); Cracowski, Jean-Luc (University Grenoble Alpes, La Tronche, France); Drici, MD (University of Nice Côte d'Azur, Nice, France); Faillie, JL (CHU Montpellier, Montpellier, France); Geniaux, Hélène (CHU de Limoges, Limoges, France); Molimard, M (Université de Bordeaux, Bordeaux, France); Orlikowski, D (Versailles Saint-Quentin-en-Yvelines University, Versailles, France); Palin, Karine (University of Bordeaux, Bordeaux, France); Pers, Y-M (CHU Montpellier, Montpellier, France); Picard, Nicolas (CHU de Limoges, Limoges, France); Simon, N (Aix-Marseille University, Marseille, France); Toussirot, E (CHU de Besancon, Besancon, France); Boger, RH (University Medical Center Hamburg-Eppendorf, Hamburg, Germany); Cascorbi, I (University of Kiel, Kiel, Germany); Mueller, SC (University Medicine Rostock, Rostock, Germany); Regenthal, R (University of Leipzig, Leipzig, Germany); Schwab, M (Eberhard Karl University of Tübingen, Tübingen, Germany); Schwaninger, MS (University of Luebeck, Luebeck, Germany); Thuermann, PA (University Witten/Herdecke, Witten, Germany); Wojnowski, L (University Medical Center Mainz, Mainz, Germany); Kouvelas, D (Aristotle University of Thessaloniki, Thessaloniki, Greece); Riba, P (Semmelweis University, Budapest, Hungary); Kerins, David M (University College, Cork, Ireland); Williams, David J (Royal College of Surgeons in Ireland, Dublin, Ireland); Cosentino, M (University of Insubria, Varese, Italy); De Ponti, Fabrizio (University of Bologna, Bologna, Italy); Filippelli, Amelia (University of Salerno, Baronissi, Italy); Leone, R (University of Verona, Verona, Italy); Locatelli, Vittorio (University of Milano - Bicocca, Monza, Italy); Jansone, Baiba (University of Latvia, Riga, Latvia); Gulbinovic, Romaldas (Vilnius University, Vilnius, Lithuania); Mifsud, Janet (University of Malta, Msida, Malta); Braszko, Jan J (Medical University of Bialystok, Bialystok, Poland); kocic, I (Medical University of Gdansk, Gdansk, Poland); Breitenfeld, Luiza (Beira Interior University, Covilh~a, Portugal); Castelo-Branco, M (University of Beira Interior, Covilh~a, Portugal); Conea, Simona (“Vasile Goldis” Western University of Arad, Arad, Romania); Magyar, Ioan (University of Oradea, Oradea, Romania); Bevc, S (University of Maribor, Maribor, Slovenia); Krzan, Mojca (University of Ljubljana, Ljubljana, Slovenia); Bernal, ML (University of Zaragoza, Zaragoza, Spain); Capellà, D (University of Girona, Girona, Spain); Carcas, A (Universidad Autónoma de Madrid, University of Maribor, Spain); De Abajo, FJ (University of Alcalá, Alcalá de Henares, Spain); Lopez-Rico, M (University of Salamanca, Salamanca, Spain); Lucena, MI (University of Malaga, Malaga, Spain); Pontes, C (Universitat Autonoma de Barcelona, Sabadell, Spain); Sanz, EJ (Universidad de La Laguna, La Laguna, Spain); Böttiger, Y (Linköping University, Linköping, Sweden); Le Grevès, Madeleine (Uppsala University, Uppsala, Sweden); de Waard-Siebinga, I (University Medical Center Groningen, Groningen, The Netherlands); Janssen, Ben JA (Maastricht University, Maastricht, The Netherlands); Knol, Wilma (University Medical Center Utrecht, Utrecht, The Netherlands); Pandit, Rahul (University Medical Center Utrecht, Utrecht, The Netherlands); van Rosse, F (Erasmus Medical Center, Rotterdam, The Netherlands); Dent, G (Keele University, Keele, United Kingdom); Ferro, Albert (King's College London, London, United Kingdom); Hitchings, AW (St George's, University of London, London, United Kingdom); Kapil, V (Queen Mary University London, London, United Kingdom); Linton, KD (University of Sheffield, Sheffield, United Kingdom); Loke, YK (University of East Anglia, Norwich, United Kingdom); Okorie, Michael (Brighton and Sussex Medical School, Brighton, United Kingdom); Plumb, Richard David (Queen's University Belfast, Belfast, United Kingdom); Pontefract, Sarah (University of Birmingham, Birmingham, United Kingdom); Ranmuthu, S (Queen Mary University London, London, United Kingdom); Sampson, AP (University of Southampton, Southampton, United Kingdom); Thanacoody, HKR (Newcastle University, Newcastle upon Tyne, United Kingdom); Whitfield, Jonathan P (University of Aberdeen, Aberdeen, United Kingdom); Wilson, Kurt (University of Manchester, Manchester, United Kingdom) Improvement and harmonization of European clinical pharmacology and therapeutics (CPT) education is urgently required. Because digital educational resources can be easily shared, adapted to local situations and re‐used widely across a variety of educational systems, they may be ideally suited for this purpose Methods With a cross‐sectional survey among principal CPT teachers in 279 out of 304 European medical schools, an overview and classification of digital resources was compiled. Results Teachers from 95 (34%) medical schools in 26 of 28 EU countries responded, 66 (70%) of whom used digital educational resources in their CPT curriculum. A total of 89 of such resources were described in detail, including e‐learning (24%), simulators to teach pharmacokinetics and/or pharmacodynamics (10%), virtual patients (8%), and serious games (5%). Together, these resources covered 235 knowledge‐based learning objectives, 88 skills, and 13 attitudes. Only one third (27) of the resources were in‐part or totally free and only two were licensed open educational resources (free to use, distribute and adapt). A narrative overview of the largest, free and most novel resources is given. Conclusion Digital educational resources, ranging from e‐learning to virtual patients and games, are widely used for CPT education in EU medical schools. Learning objectives are based largely on knowledge rather than skills or attitudes. This may be improved by including more real‐life clinical case scenarios. Moreover, the majority of resources are neither free nor open. Therefore, with a view to harmonizing international CPT education, more needs to be learned about why CPT teachers are not currently sharing their educational materials.
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- 2020
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3. Harmonizing and improving European education in prescribing: An overview of digital educational resources used in clinical pharmacology and therapeutics.
- Author
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Bakkum, Michiel J., Tichelaar, Jelle, Papaioannidou, Paraskevi, Likic, Robert, Sanz Alvarez, Emilio J., Christiaens, Thierry, Costa, João N., Mačiulaitis, Romaldas, Dima, Lorena, Coleman, Jamie, Richir, Milan C., Agtmael, Michiel A., Atanasova, Ivanka, Ganeva, Maria, Gatchev, Emil, Kostadinova, I. I., Mimica Matanovic, S., Vitezic, D, Greta, Wozniak, and Kmonickova, E.
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EDUCATIONAL resources ,SIMULATED patients ,MEDICAL schools ,MEDICAL education ,TEACHER-principal relationships ,PHARMACOLOGY - Abstract
Aim: Improvement and harmonization of European clinical pharmacology and therapeutics (CPT) education is urgently required. Because digital educational resources can be easily shared, adapted to local situations and re‐used widely across a variety of educational systems, they may be ideally suited for this purpose. Methods: With a cross‐sectional survey among principal CPT teachers in 279 out of 304 European medical schools, an overview and classification of digital resources was compiled. Results: Teachers from 95 (34%) medical schools in 26 of 28 EU countries responded, 66 (70%) of whom used digital educational resources in their CPT curriculum. A total of 89 of such resources were described in detail, including e‐learning (24%), simulators to teach pharmacokinetics and/or pharmacodynamics (10%), virtual patients (8%), and serious games (5%). Together, these resources covered 235 knowledge‐based learning objectives, 88 skills, and 13 attitudes. Only one third (27) of the resources were in‐part or totally free and only two were licensed open educational resources (free to use, distribute and adapt). A narrative overview of the largest, free and most novel resources is given. Conclusion: Digital educational resources, ranging from e‐learning to virtual patients and games, are widely used for CPT education in EU medical schools. Learning objectives are based largely on knowledge rather than skills or attitudes. This may be improved by including more real‐life clinical case scenarios. Moreover, the majority of resources are neither free nor open. Therefore, with a view to harmonizing international CPT education, more needs to be learned about why CPT teachers are not currently sharing their educational materials. [ABSTRACT FROM AUTHOR]
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- 2021
- Full Text
- View/download PDF
4. Experimental evaluation of the analgesic activity of 2-(3-diethylcarbamoyl-2-methyl-5-phenyl-pyrrol-1-yl)-3-phenyl-propionic acid
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Zlatanova, H. I., Vladimirova, S. P., Ilia Kostadinov, Delev, D. P., and Kostadinova, I. I.
5. Physiological and clinical characteristics of andropause
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Delev, D. P., Kostadinova, I. I., Ilia Kostadinov, and Ubenova, D. K.
6. Clinico-electrophysiological correlates in patients with relapsing-remitting multiple sclerosis.
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Manova MG, Kostadinova II, Chalakova-Atanasova NT, Temenlieva VK, and Petrova NS
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- Brain physiopathology, Cyclophosphamide therapeutic use, Disability Evaluation, Drug Combinations, Electric Stimulation, Electrophysiology, Evoked Potentials, Visual, Female, Glucocorticoids, Humans, Immunosuppressive Agents, Magnetics, Male, Methylprednisolone therapeutic use, Multiple Sclerosis, Relapsing-Remitting drug therapy, Multiple Sclerosis, Relapsing-Remitting physiopathology
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Introduction: The degree of neurological deficit was evaluated in patients with multiple sclerosis (MS) relapse by the Expanded Disability Status Scale (EDSS), transcranial magnetic stimulation (TMS) and visual evoked potentials (VEPs). Clinical and electrophysiological changes before and after treatment were compared in an attempt to find significant associations between the indicators of disease activity., Material and Methods: In all the patients (n = 35, mean age 32.05 +/- 2.67 years) EDSS rating was assessed prior to and 2 months after the beginning of treatment with methylprednisolone (MP)--13 patients, and with MP in combination with cyclophosphamide (CPH)--22 patients. Transcranial magnetic stimulation with measuring central latency time (CLT) was performed in 20 patients (mean age 30.85 +/- 8.01 years) before and at the end of the 2nd month after treatment with MP independently (9 patients) and MP combined with CPH (11 patients). In another 15 patients with a mean age of 33.67 +/- 7.45 years VEPs are examined (P100 latency) before and on the 2nd month after treatment with MP (4 patients) and MP combined with CPH (11 patients)., Results: CLT (P < 0.001) and P100 (P < 0.001) were significantly shortened after treatment in comparison with the baseline values. A significant correlation (P < 0.05) between CLT and the pyramid subscale was found., Conclusion: The results suggests that CTL and P100 reflect the effect of treatment on the intensity of the pathological process, the CLT correlating with the severity of the pyramid deficit according to EDSS rating in the course of the treatment.
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- 2001
7. Clinico-laboratory study of methylprednisolone and cyclophosphamide treatment in patients with multiple sclerosis relapse.
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Manova MG, Kostadinova II, and Rangelov AA
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- Adolescent, Adult, Drug Therapy, Combination, Female, Humans, Injections, Intravenous, Male, Middle Aged, Multiple Sclerosis physiopathology, Recurrence, Treatment Outcome, Anti-Inflammatory Agents therapeutic use, Cyclophosphamide therapeutic use, Immunosuppressive Agents therapeutic use, Methylprednisolone therapeutic use, Multiple Sclerosis drug therapy
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Introduction: The effect of combined treatment (methylprednisolone and cyclophosphamide) of multiple sclerosis relapse within one year was investigated in an open clinical trial study of 70 patients. The sample comprised subjects shown to have clinically proven multiple sclerosis according to the criteria of C Poser and degree of neurological deficit according to EDSS rating from 2.5 to 6.0 points., Material and Methods: Methylprednisolone (200 mg, i.v., every other day, 10 doses, total course dose 2 g) was administered to 35 patients (mean age 31.34 +/- 1.53 years). Methylprednisolone using the same schedule and cyclophosphamide (200 mg, i.v.) given in the methylprednisolone-free day, 10 doses plus 200 mg i.v. once a month in the first three consecutive months (total course dose 2.6 g) were applied in another 35 patients (mean age 33.22 +/- 1.32 years)., Results and Discussion: The changes of EDSS ratings at the end of months 1 and 12, of the CD+ T-lymphocytes subpopulations and B-lymphocytes from peripheral blood--prior to treatment and between the 5th and 9th week of treatment were compared. The neurological deficit degree according to EDSS dropped significantly (P < 0.01; P < 0.001) after one month of treatment in both groups. At the end of month 12 this indicator reached its baseline value in the group treated only with methylprednisolone while remaining significantly lower in the combined therapy group (P < 0.01). After methylprednisolone and cyclophosphamide application the suppressor/inducer CD8+ T-cells increased significantly in percentage (P < 0.05), while the values of B-lymphocytes decrease significantly (P < 0.05), in contrast to the results from the methylprednisolone-only treatment., Conclusions: The results clearly indicate the greater efficaciousness of treatment by combining two immunosuppressive drugs.
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- 2000
8. Some aspects of the immunotherapy of multiple sclerosis (literature review).
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Manova MG and Kostadinova II
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- Adjuvants, Immunologic therapeutic use, Adrenal Cortex Hormones therapeutic use, Animals, Clinical Trials as Topic, Humans, Immunosuppressive Agents therapeutic use, Immunotherapy, Multiple Sclerosis therapy
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This article reviews some immunotherapeutic approaches, based on the concept of multiple sclerosis as a progressive autoimmune disease. A special attention is given to the experimental results building up the model of autoimmune cascade and determining the directions of pathogenic treatment. The reviewed literature data highlight the pros and cons of the results of the conducted clinical trials with immunoeffective agents: corticosteroids, nonspecific immunosuppressive and contemporary immunomodulatory agents. Attention is given to the studies of combined drug therapies and the views of contemporary investigators.
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- 2000
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