98 results on '"Kotaro Morita"'
Search Results
2. Usefulness of endoscopic ultrasound‐guided transhepatic biliary drainage with a 22‐gauge fine‐needle aspiration needle and 0.018‐inch guidewire in the procedure's induction phase
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Kei Yane, Masahiro Yoshida, Takayuki Imagawa, Kotaro Morita, Hideyuki Ihara, Kota Hanada, Sota Hirokawa, Yusuke Tomita, Takeyoshi Minagawa, Yutaka Okagawa, Tetsuya Sumiyoshi, Michiaki Hirayama, and Hitoshi Kondo
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biliary stricture ,biliary drainage ,endoscopic ultrasonography ,EUS‐guided hepaticogastrostomy ,EUS‐guided hepaticojejunostomy ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Abstract Endoscopic ultrasound (EUS)‐guided transhepatic biliary drainage is usually performed with a 19‐gauge fine‐needle aspiration (FNA) needle and a 0.025‐inch guidewire. The combination of a 22‐gauge FNA needle and a 0.018‐inch guidewire is reported to be effective as a rescue option when the bile duct diameter is small or technically challenging. Experts in EUS‐guided transhepatic biliary drainage have reported that bile duct puncture with a 19‐gauge FNA needle is possible in most cases, but is not easy to reproduce by endoscopists with less experience in EUS‐guided transhepatic biliary drainage. We investigated the usefulness of EUS‐guided transhepatic biliary drainage using a 22‐gauge FNA needle and a 0.018‐inch guidewire during the procedure's induction phase. Consecutive patients who underwent EUS‐guided transhepatic biliary drainage at our institution from March 2021 to May 2023 were evaluated, and 37 were included. Biliary drainage was performed for malignant bile duct stricture in 36 patients and choledocholithiasis in one patient. The median target bile duct diameter was 4.5 mm (2.5–9.4). Biliary access, fistula dilation, and stent placement were successful in the 37 patients (100%). The median procedure time was 35 min (16–125). Adverse events occurred in four (10.8%) patients. EUS‐guided transhepatic biliary drainage using a 22‐gauge FNA needle and a 0.018‐inch guidewire is a useful and promising option for endoscopists with limited experience in EUS‐guided transhepatic biliary drainage in the procedure's induction phase.
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- 2024
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3. Initial experience of transpapillary gallbladder biopsy using newly designed device delivery system
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Kei Yane, Yusuke Tomita, Masahiro Yoshida, Kou Sasaki, Takayuki Imagawa, Kotaro Morita, Hideyuki Ihara, Takeyoshi Minagawa, Yutaka Okagawa, Michiaki Hirayama, Tetsuya Sumiyoshi, and Hitoshi Kondo
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Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Transpapillary gallbladder biopsy has been reported for the diagnosis of gallbladder disease, and this procedure requires special biopsy forceps or a large-diameter pusher catheter. We retrospectively examined consecutive patients who underwent transpapillary gallbladder biopsy using a newly designed device delivery system (Endosheather; Piolax Medical Device, Kanagawa, Japan). We evaluated 11 patients (median age, 71 years [28–85]) who underwent transpapillary gallbladder biopsy from June 2021 to July 2022. The selective gallbladder cannulation and delivery system insertion success rate was 90.9% (10/11). The target lesion biopsy success rate was 63.6% (7/11). The biopsy time (i.e., time to completion of biopsy after successful guidewire placement) was 8.7 (5.4–32.7) min. In 1 patient in whom all 6 gallbladder bile juice cytology results were benign, the biopsy result was suspicious of adenocarcinoma. The final diagnosis for this patient was gallbladder cancer. Adverse events occurred in 2 patients. In 1 patient, acute cholecystitis occurred and required emergency surgery. Transpapillary gallbladder biopsy using the Endosheather is a potential option for the diagnosis of gallbladder disease. A good indication for this technique is considered to be wall thickening at the gallbladder fundus, where it is difficult to differentiate between benign and malignant lesions by imaging modalities such as ultrasonography or endoscopic ultrasound. The addition of transpapillary gallbladder biopsy may be advantageous when performing bile juice cytology using a nasogallbladder drainage tube for the diagnosis of gallbladder disease.
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- 2023
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4. Case of needle tract seeding during preoperative neoadjuvant chemotherapy for resectable pancreatic cancer
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Kei Yane, Mai Aoki, Yusuke Tomita, Masahiro Yoshida, Kotaro Morita, Hideyuki Ihara, Tetsuya Sumiyoshi, Hitoshi Kondo, and Yumiko Oyamada
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endoscopic ultrasonography ,EUS‐FNA ,neoadjuvant chemotherapy ,pancreatectomy ,pancreatic cancer ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Abstract Reports of needle tract seeding (NTS) as a complication of endoscopic ultrasound‐guided fine‐needle aspiration (EUS‐FNA) have been increasing. To date, most of the reported cases of NTS have been diagnosed during the postoperative follow‐up period. Herein, we report a case of NTS that occurred during preoperative neoadjuvant chemotherapy after EUS‐FNA for resectable pancreatic cancer. The patient underwent transgastric EUS‐FNA for a pancreatic tail tumor. He was diagnosed as having resectable pancreatic cancer and received preoperative neoadjuvant chemotherapy. After completion of the chemotherapy, computed tomography showed a thick‐walled cyst‐like structure appearing between the pancreas and the gastric wall. Combined resection revealed adenocarcinoma invasion into the cyst‐like structure. Based on the clinical course, and surgical and pathological findings, the condition was diagnosed as NTS. It is thus crucial that after EUS‐FNA, a detailed review of the imaging findings be conducted in the preoperative period. If adhesions between the stomach and the pancreas are observed after transgastric EUS‐FNA, combined resection of the gastric wall should be considered.
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- 2023
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5. Simple transmural antegrade biopsy method for indeterminate biliary stricture using endoscopic sheath
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Kei Yane, Kotaro Morita, Tetsuya Sumiyoshi, Mai Aoki, Masahiro Yoshida, Hideyuki Ihara, and Hitoshi Kondo
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Diseases of the digestive system. Gastroenterology ,RC799-869 - Published
- 2022
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6. Genes Located on 18q23 Are Epigenetic Markers and Have Prognostic Significance for Patients with Head and Neck Cancer
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Kiyoshi Misawa, Takeharu Kanazawa, Daiki Mochizuki, Atsushi Imai, Masato Mima, Satoshi Yamada, Kotaro Morita, Yuki Misawa, Kazuya Shinmura, and Hiroyuki Mineta
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head and neck cancer ,LOH ,18q23 ,CpG island ,promoter methylation ,quantitative methylation-specific PCR ,disease-free survival ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Loss of heterozygosity (LOH) on chromosome 18q23 is associated with significantly decreased survival in head and neck cancer. In agreement with such tumor suppressive roles, the loss of function of genes located in this region can be achieved through LOH and promotor hypermethylation. In this study, the methylation status of promoters of 18q23 genes in 243 head and neck cancer patients was assessed by quantitative methylation-specific PCR. Promoter methylation was then compared to various clinical characteristics and patient survival. GALR1 and SALL3 promoter methylation correlated with reduced disease-free survival (log-rank test, p = 0.018 and p = 0.013, respectively). Furthermore, based on multivariate Cox proportional hazards analysis, these methylation events were associated with poor disease-free survival, with hazard ratios of 1.600 (95% confidence interval: CI, 1.027–2.493; p = 0.038) and 1.911 (95% CI, 1.155–3.162; p = 0.012), respectively. By comparison, GALR1 and SALL3 methylation were not prognostic for overall survival in The Cancer Genome Atlas (TCGA) cohort. Our findings suggest that the methylation status of 18q23 genes could serve as important biomarkers for the prediction of clinical outcomes in well-annotated head and neck squamous cell carcinoma cohorts. GALR1 and SALL3 methylation could thus help to facilitate risk stratification for individualized treatment.
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- 2019
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7. A Case of Traumatic Retropharyngeal Hematoma
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Kaya Takahashi, Masataka Sone, Mamoru Masuda, Arika Matsushita, Kotaro Kano, Kotaro Morita, and Jun Okamura
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Otorhinolaryngology - Published
- 2023
8. Extraction Behavior of Metal-Thiocyanato Complexes into Third Phase Formed in an Ionic Liquid Extraction System Using Trioctylphosphine Oxide
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Mizuki TOITA, Kotaro MORITA, and Naoki HIRAYAMA
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General Chemical Engineering ,General Chemistry - Published
- 2022
9. Possible Association between Physical and Cognitive Function and Stumbling and Falling in Elderly Workers
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Kotaro Morita, Kazuhiro Nogawa, Yuuka Watanabe, Sayaka Sakuma, Koichi Sakata, Katsuyuki Ito, Chika Kumeda, and Yasushi Suwazono
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Male ,Cognition ,Movement Disorders ,Hand Strength ,Health, Toxicology and Mutagenesis ,Public Health, Environmental and Occupational Health ,Humans ,Female ,elderly workers ,stumbling ,fall injury ,physical function ,cognitive function ,Gait ,Postural Balance ,Aged - Abstract
The aim of this paper is to examine the association between physical and cognitive function and stumbling and falling in elderly workers by conducting work-related questionnaire surveys and physical and cognitive function measurements. A total of 611 men and 121 women aged 40–69 years who participated in physical function measurements between June 2017 and June 2021 were included in the study. The general physical function measurements of upper and lower limb muscle strength, dynamic and static balance, and agility and cognitive function included grip strength, Repeated Rise Test, Trail Making test (TMT), and Three-Meter Time Up Go Test (TUG). We also asked the men and women about their experience of falling and stumbling. Logistic regression analysis showed significant odds ratios (OR) for the associations between stumbling in men and age (OR: 1.98), mental burden (OR: 2.44), frequency of field work (OR: 1.74), seated stepping test count (OR: 0.95), and TMTB time (OR: 0.99). Significant ORs were found between falling in men and age (OR: 2.55), mental burden (OR: 2.40), exercise habits (OR: 2.55), and smoking (OR: 2.00). Significant ORs were found between stumbling in women and d_TUG (OR: 1.59) and mental burden (OR: 6.42). The study suggests that there may be an association between cognitive and physical decline and stumbling and falling in elderly workers.
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- 2022
10. [Competencies expected of labor and social security attorneys in harmonizing work with diseases treatment]
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Hideki Morimoto, Yoshiyuki Shibata, Daisuke Kataoka, Kosuke Sakai, Rima Hiramatsu, Kotaro Morita, Tadashi Wakabayashi, and Koji Mori
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Public Health, Environmental and Occupational Health ,General Medicine ,Toxicology - Abstract
Labor and social security attorneys (LSSAs) are involved in various positions in harmonizing work with disease treatment; however, their qualification requirements do not include knowledge about the same. Expectations of their involvement in harmonizing work with disease treatment are insufficient. This study aimed to identify the competencies expected of the labor and social security LSSAs in harmonizing work with disease treatment.In step 1, semi-structured interviews were conducted with LSSAs in this field. In step 2, a draft competency list was created based on the interview results. In step 3, the Delphi method was used to conduct a questionnaire survey among LSSAs who had over 10 consultation cases on harmonizing work with disease treatment, and they were asked about the level of importance (how important they thought it was to promote harmonizing work with disease treatment) and level of achievement (how much they had achieved). We also asked them about the competencies they considered necessary and added them as additional items in the draft. In step 4, the results of the previous step were presented to the participants who had given valid answers in step 3, and they were asked whether they would adopt the items as competencies. Items with an agreement rate of 80% or higher were considered competency items. Additionally, we asked them about the level of importance and level of achievement of the additional items created in step 3.In step 1, 24 LSSAs participated, and in step 2, a draft competency list of six major items, 18 medium items, and 71 minor items was created. In step 3, 49 LSSAs participated and 41 cooperated (response rate: 83.6%). Five items were selected for the draft competency list to be newly added. In step 4, 30 LSSAs cooperated (response rate: 73.1%). None of the items had an agreement rate of less than 80%, and over 40% of the items had an agreement rate of 100%. As a result, six major items, 18 medium items, and 76 minor items were selected for the competency list.This study identified the competencies expected of labor and social security LSSAs in harmonizing work with disease treatment. The results of this study can be used as a reference for developing a systematic training curriculum for LSSAs in this field in the future.
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- 2022
11. Case of needle tract seeding during preoperative neoadjuvant chemotherapy for resectable pancreatic cancer
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Kei Yane, Mai Aoki, Yusuke Tomita, Masahiro Yoshida, Kotaro Morita, Hideyuki Ihara, Tetsuya Sumiyoshi, Hitoshi Kondo, and Yumiko Oyamada
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General Medicine - Published
- 2022
12. Small Bowel Perforation Caused by Metastasis from Oropharyngeal Carcinoma
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Kotaro Morita, Satoshi Yamada, Yuki Misawa, Teruyuki Kato, Maki Arai, and Kunihiro Mizuta
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medicine.medical_specialty ,Otorhinolaryngology ,Oropharyngeal Carcinoma ,business.industry ,Internal medicine ,medicine ,business ,medicine.disease ,Gastroenterology ,Small bowel perforation ,Metastasis - Published
- 2021
13. Concurrent Human Papillomavirus-Positive Squamous Carcinoma of the Tonsil in a Married Couple
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Kotaro Morita, Jun Okamura, Arika Matsushita, Kaya Takahashi, Kiyoshi Misawa, Kotaro Kano, Daiki Mochizuki, Hiroyuki Mineta, Seiji Hosokawa, Mamoru Masuda, Masataka Sone, and Atsushi Imai
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Oncology ,Human Papillomavirus Positive ,medicine.medical_specialty ,medicine.anatomical_structure ,Otorhinolaryngology ,business.industry ,Internal medicine ,Tonsil ,medicine ,business ,Squamous carcinoma - Published
- 2021
14. A Case of Recurrent Inverted Papilloma of the Maxillary Sinus Resected Using 'the Direct Approach to the Anterior and Lateral Part of the Maxillary Sinus with an Endoscope'
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Arika Matsushita, Shigeru Matsuda, Akitoshi Hayashi, Kotaro Morita, Junya Kita, Kotaro Kano, Mamoru Masuda, and Jun Okamura
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medicine.anatomical_structure ,Otorhinolaryngology ,Maxillary sinus ,Endoscope ,business.industry ,medicine ,Inverted papilloma ,Anatomy ,business ,medicine.disease - Published
- 2021
15. An absorption spectrophotometer compatible paper-based thin-layer cuvette with an integrated pneumatic pump
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Honomi Koiso, Reina Kudo, Naoki Hirayama, and Kotaro Morita
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Polypropylene ,Materials science ,Absorption spectroscopy ,business.industry ,Spectrum Analysis ,General Chemical Engineering ,Thin layer ,General Engineering ,Water ,Paper based ,Analytical Chemistry ,Cuvette ,chemistry.chemical_compound ,Optical path ,chemistry ,Spectrophotometry ,Optoelectronics ,business ,Absorption (electromagnetic radiation) - Abstract
This study presents a paper-based thin-layer optical cuvette for absorption spectroscopy with a pneumatically driven pump for the introduction of an aqueous sample. The three major components, a sample reservoir, an open-channel as an optical path and a pneumatic pump, are patterned in polypropylene paper using an electronic cutting machine. When sealed with transparent tape, the patterned paper serves as the side walls of the paper-based cuvette with an integrated pneumatic pump. Due to the reduced pressure inside the open-channel caused by the depression of the pump with a finger, aqueous samples spotted onto the reservoir are introduced into the open-channel of the paper-based cuvette. We demonstrated that the paper-based cuvettes are compatible with conventional spectrophotometers for absorption spectroscopic measurements and capable of quantifying the concentrations of various colored dyes in aqueous samples.
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- 2021
16. Two Cases of Osseous Choristoma Occurring at the Base of the Tongue
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Hiroyuki Mineta, Kotaro Kano, Arika Matsushita, Akitoshi Hayashi, Mamoru Masuda, Kotaro Morita, and Jun Okamura
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Otorhinolaryngology ,business.industry ,Osseous choristoma ,Medicine ,Base of tongue cancer ,Anatomy ,business - Published
- 2021
17. A Case of Submandibular Schwannoma Arising from the Submandibular Ganglion
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Kotaro Kano, Mamoru Masuda, Masataka Sone, Akitoshi Hayashi, Kotaro Morita, Arika Matsushita, Jun Okamura, and Kaya Takahashi
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Pathology ,medicine.medical_specialty ,Otorhinolaryngology ,business.industry ,medicine ,Submandibular ganglion ,Schwannoma ,medicine.disease ,business - Published
- 2021
18. Mutual Separation of Fe(II) and Fe(III) Using Cyclohexane/Water/ Ionic-liquid Triphasic Extraction System with 2,2′-Bipyridine and Tri-n-octylphosphine Oxide
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Naoki Hirayama, Kotaro Morita, and Mizuki Toita
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Cyclohexane ,010401 analytical chemistry ,Extraction (chemistry) ,Oxide ,02 engineering and technology ,021001 nanoscience & nanotechnology ,01 natural sciences ,2,2'-Bipyridine ,0104 chemical sciences ,Analytical Chemistry ,chemistry.chemical_compound ,Bipyridine ,chemistry ,Phase (matter) ,Ionic liquid ,0210 nano-technology ,Masking agent ,Nuclear chemistry - Abstract
The triphasic extraction system with two extract phases can be used to separate two materials simultaneously into each phase. In this article, a possible mutual separation of Fe(II) and Fe(III) was studied using the cyclohexane/water/ionic liquid (IL) triphasic extraction system for Fe speciation. For Fe(II) and Fe(III) extraction, 2,2'-bipyridine (bpy) and tri-n-octylphosphine oxide (TOPO) were selected as extractants, respectively. It was suggested that [FeII(bpy)3]2+ and FeIII(TOPO)43+·3Tf2N- were extracted into the IL (1-butyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide, C4mimTf2N) phase and the cyclohexane phase, respectively, and both of the extractants also acted as masking agents. On simultaneous separation using the triphasic system, Fe(II) and Fe(III) were quantitatively extracted into the IL phase and the cyclohexane phase, respectively, and their mutual separation was achieved.
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- 2020
19. Capillary Electrophoretic Characterization of Carbon Nanodots Prepared from Glutamic Acid in an Electric Furnace
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Naoki Hirayama, Kotaro Morita, Hitoshi Mizuguchi, Toshio Takayanagi, and Sota Iwasaki
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Chromatography ,Chemistry ,Capillary action ,General Medicine ,Glutamic acid ,Electric furnace ,Carbon nanodot ,Glutathione ,Ion ,Capillary electrophoresis ,Electrophoresis ,chemistry.chemical_compound ,Adsorption ,Moiety ,Carboxylate ,Nuclear chemistry - Abstract
Carbon nanodots (CNDs) prepared from glutamic acid or glutathione in an electric furnace were characterized by capillary electrophoresis. Two major peaks were detected in the electropherograms by capillary zone electrophoresis, corresponding to anionic and less-charged CNDs. The effective electrophoretic mobility of the anionic CND formed from glutamic acid was almost identical over neutral to weakly alkaline pH range, and the CND would not contain significant amount of amino group. On the other hand, the effective electrophoretic mobility tended to decrease with decreasing pH at weakly acidic pH conditions, suggesting the functional groups of carboxylate moiety on the anionic CNDs. Dodecyl sulfate ion was added in the separation buffer to give anionic charge to the less-charged CND by adsorption. However, the anionic charge induced was little, and the dodecyl sulfate ion was not likely adsorbed on the less-charged CND and the CND would be hydrophilic.
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- 2020
20. Capillary Electrophoretic Characterization of Water-soluble Carbon Nanodots Formed from Glutamic Acid and Boric Acid under Microwave Irradiation
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Kotaro Morita, Toshio Takayanagi, Naoki Hirayama, Hitoshi Mizuguchi, Yuta Becchaku, Sota Iwasaki, and Shun Yabe
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Aqueous solution ,capillary electrophoresis ,affinity capillary electrophoresis ,Carbon nanodot ,Micellar electrokinetic chromatography ,Analytical Chemistry ,Hydrophobic effect ,Boric acid ,Electrophoresis ,chemistry.chemical_compound ,Capillary electrophoresis ,chemistry ,micellar electrokinetic chromatography ,Moiety ,characterization ,Amine gas treating ,Nuclear chemistry - Abstract
Water-soluble carbon nanodots (CND) were synthesized under microwave irradiation from glutamic acid or glutamic acid-boric acid mixture. The CNDs were collected in an aqueous solution through size fractionation by centrifugal filtration. The CNDs thus prepared were subjected to characterization by capillary electrophoresis (CE). A peak signal of anionic substance was detected in the electropherogram, and it was found to be a major component of the CNDs. The effective electrophoretic mobility of the major component was almost identical over the pH range between 6.7 and 11.6, suggesting that the functional group of amine or boric acid moiety was not included in the CNDs. The effective electrophoretic mobility decreased at an acidic pH of less than 5, and it was suggested that carboxylate moiety was included in the CNDs. A signal of less-charged CNDs was also detected in the electropherogram, and the CNDs were characterized by a CE format of micellar electrokinetic chromatography. Two or four peaks were detected just after the electroosmotic flow; the less-charged CNDs were thus hydrophilic. The affinity interaction was also examined between the major anionic CNDs and a hydrophobic pairing cation. The peak signal of the major anionic CNDs broadened, and its theoretical number of plates decreased in the presence of tetrabutylammonium ion in the separation buffer. A small portion of the anionic CNDs were a little hydrophobic at different degrees, and their effective electrophoretic mobility decreased by the hydrophobic interaction, resulting in peak broadening of the anionic CNDs.
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- 2020
21. Examining competencies for labor and social security attorneys in the field of occupational mental health
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Yoshiyuki Shibata, Koji Mori, Kotaro Morita, Hideki Morimoto, and Kotaro Kayashima
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Response rate (survey) ,Medical education ,Public Health, Environmental and Occupational Health ,Delphi method ,General Medicine ,Toxicology ,Mental health ,Work related ,Social Security ,Field (computer science) ,Social security ,Lawyers ,Mental Health ,Professional Competence ,Japan ,Work (electrical) ,Humans ,Psychology ,Set (psychology) ,Occupational Health - Abstract
AIM Labor and social security attorneys (LSSAs) are involved in the field of occupational mental health. However, little attention has been paid to the involvement of LSSAs in this field. This study investigated the occupational mental health competencies that are expected of LSSAs. SUBJECTS AND METHODS Our investigation utilized the Delphi method. In Step 1, we conducted semi-structured interviews with LSSAs and then created an initial list of competencies based on the interviews and a previous investigation. In Step 2, we recruited LSSAs with 10 or more cases related to occupational mental health. They completed a questionnaire assessing the importance of their work (how important they felt it was to conduct work related to mental health) and level of achievement (how much they felt they had achieved). The respondents were also asked to provide additional competencies (not listed on the questionnaire) if they regarded them as necessary for their work, and these were later added to the list of proposed competencies. In Step 3, we presented the results of Step 2 to the same respondents and asked them to rate their agreement with the proposed competencies. Items with agreement of 80% or higher were set as competencies. We also asked LSSAs about the level of importance of their work and their perceived level of achievement with regard to the additional items created in Step 2. Items for which the level of achievement fell below the median were extracted even if the level of importance of the work fell at or above the median. RESULTS We recruited 8 LSSAs in Step 1 and created a list of 68 preliminary competencies in 20 fields. We recruited 57 LSSAs in Step 2, and 45 LSSAs completed the survey (response rate: 78.9%). Seven competencies were added to the list as a result. We recruited 34 LSSAs in Step 3 (response rate: 75.6%) . Two items with an agreement rate of less than 80% were removed, resulting in 73 competencies in 20 fields. One of the items with an agreement rate of 100% was "The plan is based on the merits and disadvantages (risks) for both labor and management." CONCLUSIONS This study identified the competencies required of LSSAs in the field of occupational mental health. Our findings suggest that specifying these competencies will enable efficient training of LSSAs.
- Published
- 2020
22. Synergistic Ion-pair Extraction and Separation of Trivalent Lanthanoid Ions with 4-Isopropyltropolone and 1,10-Phenanthroline into o-Dichlorobenzene
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Hisanori Imura, Kotaro Morita, Hirohisa Nagatani, Yoshio Nishiyama, and Takuya Yamashita
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chemistry.chemical_classification ,Lanthanide ,4-isopropyltropolone ,chemistry.chemical_compound ,chemistry ,Phenanthroline ,Inorganic chemistry ,Extraction (chemistry) ,Salt (chemistry) ,Decane ,Toluene ,Analytical Chemistry ,Ion - Abstract
The synergistic extraction of trivalent lanthanoid (Ln(III)) ions with 4-isopropyltropolone (Hipt) and 1,10-phenanthroline (phen) in o-dichrolobenzene (DCB) was investigated. The synergistic effect in DCB is more significant than that in toluene, and the polynuclear complexes found in toluene are not formed in DCB. Based on the 3-dimensional equilibrium analysis, the extracted species for La(III), Eu(III), and Lu(III) are found to be ion-pairs, such as Ln(ipt)2phen·ClO4 and Ln(ipt)2(phen)·ClO4 in the presence of NaClO4 as a salt, and the extraction constants of the respective species were determined. The simultaneous extraction of different lanthanoids in the present extraction system was demonstrated. The separation factors between lighter lanthanoids were larger than those with 2-ethylhexyl phosphonic acid mono-2-ethylhexyl ester, an excellent extractant for the separation of lanthanoid ions, in decane.
- Published
- 2019
23. Successful recanalization of complete bile duct obstruction using piercing technique under cholangioscopic guidance
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Tetsuya Sumiyoshi, Masahiro Yoshida, Hideyuki Ihara, Hitoshi Kondo, Mai Aoki, Kei Yane, and Kotaro Morita
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medicine.medical_specialty ,Biliary Tract Surgical Procedures ,medicine.anatomical_structure ,Cholestasis ,business.industry ,Bile duct ,Gastroenterology ,Medicine ,Humans ,business ,Surgery - Published
- 2021
24. 5-Hydroxymethylcytosine and ten-eleven translocation dioxygenases in head and neck carcinoma
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Takuya Nakagawa, Tomoya Kurokawa, Satoshi Yamada, Atsushi Imai, Kiyoshi Misawa, Yuki Misawa, Shiori Endo, Masato Mima, Kotaro Morita, Ryuji Ishikawa, and Daiki Mochizuki
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0301 basic medicine ,disease-free survival ,Chromosomal translocation ,Biology ,HNSCC ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Gene expression ,medicine ,Gene ,5-Hydroxymethylcytosine ,Univariate analysis ,Dioxygenase activity ,medicine.disease ,Head and neck squamous-cell carcinoma ,5-hmC ,030104 developmental biology ,DNA demethylation ,Oncology ,chemistry ,030220 oncology & carcinogenesis ,Cancer research ,ELISA ,TET ,Research Paper - Abstract
Ten-eleven translocation (TET) enzymes are implicated in DNA demethylation through dioxygenase activity, which converts 5-methylcytosine to 5-hydroxymethylcytosine (5-hmC). However, the specific roles of TET enzymes and 5-hmC levels in head and neck squamous cell carcinoma (HNSCC) have not yet been evaluated. In this study, we analyzed 5-hmC levels and TET mRNA expression in a well-characterized dataset of 117 matched pairs of HNSCC tissues and normal tissues. 5-hmC levels and TET mRNA expression were examined via enzyme-linked immunosorbent assay and quantitative real-time PCR, respectively. 5-hmC levels were evaluated according to various clinical characteristics and prognostic implications. Notably, we found that 5-hmC levels were significantly correlated with tumor stage (P = 0.032) and recurrence (P = 0.018). Univariate analysis revealed that low levels of 5-hmC were correlated with poor disease-free survival (DFS; log-rank test, P = 0.038). The expression of TET family genes was not associated with outcomes. In multivariate analysis, low levels of 5-hmC were evaluated as a significant independent prognostic factor of DFS (hazard ratio: 2.352, 95% confidence interval: 1.136-4.896; P = 0.021). Taken together, our findings showed that reduction of TET family gene expression and subsequent low levels of 5-hmC may affect the development of HNSCC.
- Published
- 2019
25. Three Cases of Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features
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Kotaro Morita, Yoshiyuki Iida, Tomoyuki Kamijo, and Tetsuro Onitsuka
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Pathology ,medicine.medical_specialty ,Otorhinolaryngology ,business.industry ,Noninvasive follicular thyroid neoplasm with papillary-like nuclear features ,Medicine ,business - Published
- 2019
26. Acantholytic Squamous Cell Carcinoma and Salivary Duct Carcinoma Ex-pleomorphic Adenoma of the Submandibular Gland: A Report of Two Extremely Rare Cases with an Immunohistochemical Analysis
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Takuya Kawasaki, Noriko Hamaguchi, Yoshiyuki Iida, Kotaro Morita, Takashi Sugino, Kimihide Kusafuka, Takashi Mukaigawa, Takashi Nakajima, Tetsuro Onitsuka, Tomoyuki Kamijo, and Yukio Nishiya
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Male ,0301 basic medicine ,Pathology ,medicine.medical_specialty ,Adenoma, Pleomorphic ,Pathology and Forensic Medicine ,Salivary duct carcinoma ,Neoplasms, Multiple Primary ,Pleomorphic adenoma ,03 medical and health sciences ,Cytokeratin ,0302 clinical medicine ,Biomarkers, Tumor ,medicine ,Humans ,Salivary Ducts ,Aged ,Salivary gland ,Squamous Cell Carcinoma of Head and Neck ,business.industry ,Acantholysis ,medicine.disease ,Immunohistochemistry ,Submandibular gland ,Carcinoma, Ductal ,Submandibular Gland Neoplasms ,stomatognathic diseases ,030104 developmental biology ,Carcinoma ex pleomorphic adenoma ,medicine.anatomical_structure ,Oncology ,Otorhinolaryngology ,030220 oncology & carcinogenesis ,Female ,business - Abstract
Carcinoma ex pleomorphic adenoma (CXPA) is a malignant tumor of the salivary gland that arises from pleomorphic adenoma (PA). Squamous cell carcinoma (SCC) is extremely rare in the salivary glands. We report two cases of acantholytic SCC (ASCC) ex PA. Case 1 involved a 72-year-old female, and case 2 involved a 67-year-old male. Histologically, both cases involved PA, and salivary duct carcinoma (SDC) components, which were positive for androgen receptor (AR) and gross cystic disease fluid protein (GCDFP)-15 but negative for HER2, were seen in the intracapsular regions. The invasive components consisted of ASCC, which were positive for cytokeratin 5/6 and p63 but negative for AR and GCDFP-15. The SDC and ASCC components were positive for the epidermal growth factor receptor. In both cases, the cytoplasmic localization or decreased expression of E-cadherin was observed in the ASCC. In the early phase, CXPA might emerge as SDC, and it might change into SCC as it invades beyond the capsule due to changes in microenvironment. Also, the aberrant expression of E-cadherin is related to acantholysis in SCC.
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- 2018
27. Depth of invasion in superficial oral tongue carcinoma quantified using intraoral ultrasonography
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Yoshiyuki Iida, Tomoyuki Kamijo, Kimihide Kusafuka, Noriko Hamaguchi, Tetsuro Onitsuka, Kotaro Morita, Katsuhiro Omae, and Yukio Nishiya
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business.industry ,Cancer ,030206 dentistry ,medicine.disease ,Balloon ,Primary tumor ,humanities ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,Otorhinolaryngology ,Depth of invasion ,Tongue ,030220 oncology & carcinogenesis ,Tongue Carcinoma ,Carcinoma ,medicine ,Ultrasonography ,Nuclear medicine ,business - Abstract
Objective Depth of invasion (DOI) in oral carcinoma has been integrated into the primary tumor categories in the current tumor-node-metastasis staging (8th edition). However, there is no standard modality to determine DOI preoperatively. The aims of the present study were to evaluate the accuracy of a preoperative measurement of DOI using ultrasonography (US) for superficial oral tongue carcinomas, and to correlate the values obtained with histologically determined DOI measurements. Methods We retrospectively analyzed the records of 56 patients with oral tongue carcinoma who underwent intraoral US preoperatively, followed by curative surgery at the Shizuoka Cancer Center Hospital in Japan. For the measurement of DOI with US, our unique technique (water balloon method) was evaluated. Results The histologically measured tumor size (maximum diameter) showed a distribution of 7.0 to 40.0 mm (mean, 18.6 mm). The correlation between the US-obtained and histologically obtained DOIs was significant (r = 0.867; P 5 mm were 92.3% and 70.6%, respectively. Conclusion Intraoral US provides sufficient accuracy for the measurement of tumor DOI in oral tongue carcinoma and is complementary in assessing superficial lesions. Level of evidence 4. Laryngoscope, 128:2778-2782, 2018.
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- 2018
28. Repeated cerebellar infarction in the affected nondominant vertebral artery distribution with reversible vertebral artery occlusion elicited by head tilt: illustrative case
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Hitoshi Hasegawa, Yukihiko Fujii, Kouichirou Okamoto, Kotaro Morita, Shinji Nakazato, Tomoaki Suzuki, Masato Watanabe, Hideki Tashi, Takanori Nozawa, Kunio Motohashi, Kei Watanabe, and Hiroyuki Kawashima
- Subjects
Head tilt ,business.industry ,Vertebral artery ,medicine.artery ,medicine ,Vertebral artery occlusion ,Distribution (pharmacology) ,Cerebellar infarction ,General Medicine ,Anatomy ,business - Abstract
BACKGROUNDBow hunter’s syndrome or stroke (BHS) is characterized by rotational vertebrobasilar insufficiency elicited by rotation of the neck. It is caused by dynamic and reversible occlusion of the vertebral artery (VA). Reversible symptoms of rotational vertebrobasilar insufficiency are described as bow hunter’s syndrome, although brain infarction is rarely reported as bow hunter’s stroke.OBSERVATIONSA 70-year-old man experienced repeated cerebellar infarctions three times in the posterior inferior cerebellar artery (PICA) distribution of the nondominant right VA connecting the basilar artery. The onset of symptoms indicating cerebellar infarcts and the patient’s head position changes were unrelated. Dynamic digital angiography (DA) revealed that the nondominant right VA was occluded by an osteophyte from the C4 vertebral body, and the right PICA branches were shown to be passing through the distal right VA from the left VA. These findings were observed when the patient’s head was tilted to the right. An arterio-arterial embolic mechanism was suggested as the cause of repeated cerebellar infarctions.LESSONSTransient nondominant VA occlusion has been rarely reported as a cause of BHS when the head is tilted. To confirm the diagnosis of BHS, additional head tilt is recommended when performing dynamic DA in patients with a cervical osteophyte.
- Published
- 2021
29. Does second-look endoscopy reduce the bleeding after gastric endoscopic submucosal dissection for patients receiving antithrombotic therapy?
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Hiroya Sakano, Kotaro Morita, Takeyoshi Minagawa, Kaho Tokuchi, Hitoshi Kondo, Yutaka Okagawa, Tetsuya Sumiyoshi, Takeshi Uozumi, Michiaki Hirayama, Yusuke Tomita, Hideyuki Ihara, Ryoji Fujii, Kei Yane, and Masahiro Yoshida
- Subjects
Male ,Cancer Research ,medicine.medical_specialty ,Endoscopic Mucosal Resection ,Second look endoscopy ,Postoperative Hemorrhage ,Fibrinolytic Agents ,Surgical oncology ,Stomach Neoplasms ,Antithrombotic ,Gastroscopy ,Genetics ,medicine ,Humans ,Neoplasms, Glandular and Epithelial ,RC254-282 ,Aged ,Average risk ,medicine.diagnostic_test ,business.industry ,Incidence (epidemiology) ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Endoscopic submucosal dissection ,Antithrombotic agents ,Prognosis ,Second-look endoscopy ,Combined Modality Therapy ,Endoscopy ,Surgery ,Oncology ,Anticoagulant therapy ,Second-Look Surgery ,Case-Control Studies ,Female ,business ,Follow-Up Studies ,Research Article - Abstract
Background In patients with average risk of bleeding, second-look endoscopy does not reportedly reduce bleeding after gastric endoscopic submucosal dissection. However, effectiveness of second-look endoscopy for patients with a high risk of bleeding, such as those who are taking antithrombotic agents, is unclear. Hence, this study aims to clarify the effectiveness of second-look endoscopy for patients with antithrombotic therapy. Methods We studied 142 consecutive patients with 173 gastric epithelial neoplasms who were routinely taking antithrombotic agents and were treated by endoscopic submucosal dissection at Tonan Hospital between November 2013 and December 2019. They were classified into two groups: those with second-look endoscopy (SLE group, 69 patients with 85 lesions) and those without second-look endoscopy (non-SLE group, 73 patients with 88 lesions). The incidence of post-endoscopic submucosal dissection bleeding was compared between the SLE and non-SLE groups. Results There were no statistical differences in the rate of patients undergoing single antiplatelet therapy, single anticoagulant therapy, and multiple therapy between the SLE and non-SLE groups (SLE group vs. non-SLE group; 32 [46.4%], 16 [23.2%], and 21 [30.4%] patients vs. 37 [50.7%], 20 [27.4%], and 16 [21.9%] patients, respectively; p = 0.50). Post-endoscopic submucosal dissection bleeding incidence was 21.7% (15/69) and 21.9% (16/73) in the SLE and non-SLE groups, respectively, and did not significantly differ between the two groups (p = 0.98). Conclusions For patients taking antithrombotic agents, the incidence of post-endoscopic submucosal dissection bleeding was not reduced by second-look endoscopy.
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- 2020
30. A Case of Deep Neck Infection with Extensive Skin Necrosis
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Kunihiro Mizuta, Teruyuki Kato, Maki Arai, Hiroyuki Mineta, Seiji Hosokawa, Kotaro Morita, and Satoshi Yamada
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Pathology ,medicine.medical_specialty ,Necrosis ,Otorhinolaryngology ,business.industry ,medicine ,medicine.symptom ,business - Published
- 2018
31. Effects of Alcohol Consumption and Smoking on the Onset of Hypertension in a Long-Term Longitudinal Study in a Male Workers’ Cohort
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Yuka Watanabe, Kazuhiro Nogawa, Koichi Sakata, Yasushi Suwazono, Hideki Morimoto, Tamotsu Nagao, and Kotaro Morita
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Male ,medicine.medical_specialty ,Longitudinal study ,hypertension ,Alcohol Drinking ,alcohol consumption ,Health, Toxicology and Mutagenesis ,Blood Pressure ,Article ,smoking ,Cohort Studies ,Risk Factors ,workers’ cohort ,Internal medicine ,long-term longitudinal study ,medicine ,Humans ,Blood test ,Longitudinal Studies ,pooled logistic regression analysis ,medicine.diagnostic_test ,business.industry ,Public Health, Environmental and Occupational Health ,Odds ratio ,Confidence interval ,Blood pressure ,Cohort ,Medicine ,business ,Body mass index ,Cohort study - Abstract
Aim: To determine the effects of alcohol consumption and smoking on the onset of hypertension in a long-term longitudinal study. Methods: 7511 non-hypertensive male workers were enrolled. This cohort study was performed over an 8-year period using the results of the annual workers-health screening. The end-point was defined as systolic blood pressure ≥ 140 mmHg, diastolic blood pressure ≥ 90 mmHg, or use of antihypertensive drugs. For alcohol consumption, weekly alcohol intake (g ethanol/week) was estimated (1 “gou” = 22 g ethanol). Annual survey data were analyzed by pooled logistic regression that included alcohol consumption, smoking, age, body mass index, job schedule types, habitual exercise, and blood test measurements into the statistical model. Results: A significant positive dose–response relationship between alcohol consumption and onset of hypertension was observed, with synergistic health effects present. Compared with abstainers and nonsmokers, the adjusted odds ratios (95% confidence interval) for the onset of hypertension were: 1.51 (1.27–1.79) for 154 g ethanol/week and nonsmokers, and 1.81 (1.54–2.11) for 154 g ethanol/week and smokers. An interaction between alcohol and smoking was confirmed. Conclusions: This study provided information useful to the prevention of hypertension. By reducing alcohol consumption and smoking simultaneously, the risk of hypertension may be considerably lowered.
- Published
- 2021
32. Synergistic Ion-pair Extraction of Strontium Ion with Tri-n-octylphosphine Oxide and Dicyclohexano-18-crown-6
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Kotaro Morita, Naoki Hirayama, and Mami Onizaki
- Subjects
chemistry.chemical_classification ,Strontium ,Ligand ,Tri-n-octylphosphine oxide ,010401 analytical chemistry ,Inorganic chemistry ,Extraction (chemistry) ,Oxide ,chemistry.chemical_element ,010402 general chemistry ,01 natural sciences ,0104 chemical sciences ,Analytical Chemistry ,Divalent ,Ion ,chemistry.chemical_compound ,chemistry ,Imide ,Nuclear chemistry - Abstract
The co-use of two neutral ligands, tri-n-octylphosphine oxide (TOPO) and dicyclohexano-18-crown-6 (DC18C6), for ion-pair extraction of divalent strontium (Sr2+) with bis(trifluoromethanesulfonyl)imide anion (Tf2N-) showed unique synergistic effect. The extracted species in use of a single ligand is Sr(TOPO)32+·2Tf2N- or Sr(DC18C6)2+·2Tf2N-, whereas the co-use resulted in extraction enhancement based on additional formation of Sr(DC18C6)(TOPO)2+·2Tf2N- and Sr(DC18C6)(TOPO)22+·2Tf2N-.
- Published
- 2016
33. Formation of Minimal Third Phase in Ionic Liquid Extraction System with Trioctylphosphine Oxide and Its Possible Application to Extraction Concentration
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Mizuki Toita, Kotaro Morita, and Naoki Hirayama
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010401 analytical chemistry ,Extraction (chemistry) ,Aqueous two-phase system ,010402 general chemistry ,01 natural sciences ,0104 chemical sciences ,Analytical Chemistry ,chemistry.chemical_compound ,chemistry ,Third phase ,Phase (matter) ,Ionic liquid ,Lipophilicity ,Imide ,Trioctylphosphine oxide ,Nuclear chemistry - Abstract
The third-phase formation behavior in ionic liquid (IL) extraction system using trioctylphosphine oxide (TOPO) was investigated. In the use of a relatively less-lipophilic IL, such as 1-butyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide (C4mimTf2N), the third phase was formed between the aqueous phase and the IL phase. The third phase seems to have a relatively high lipophilicity compared to the IL phase. The main components of the third phase were suggested as being (H3O)TOPO+, IL anion (Tf2N-), IL cation (C4mim+) and free TOPO. In addition, the third phase showed an extraction concentration ability for the Fe(III)-thiocyanato complex.
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- 2018
34. Ionic Liquid Chelate Extraction Behavior of Trivalent Group 13 Metals into 1-Alkyl-3-methylimidazolium Bis(trifluoromethanesulfonyl)imides Using 8-Quinolinol as Chelating Extractant
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Kotaro Morita, Naoki Hirayama, and Ayano Eguchi
- Subjects
chemistry.chemical_classification ,Extraction (chemistry) ,Cationic polymerization ,chemistry.chemical_element ,Analytical Chemistry ,chemistry.chemical_compound ,chemistry ,Ionic liquid ,Chelation ,Gallium ,Selectivity ,Imide ,Alkyl ,Nuclear chemistry - Abstract
Ionic liquid (IL) chelate extraction behavior of trivalent Group 13 metals including aluminum(III), gallium(III) and indium(III) with 8-quinolinol (HQ) was investigated using three 1-alkyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide (CnmimTf2N, n = 2, 4 and 8) ILs. Although the three extraction systems showed similar extraction selectivity among the metals, the extractability order for the metals among the extraction systems was C8mimTf2N > C4mimTf2N > C2mimTf2N, which was the same as the order of hydrophobicity in the IL cation. Only the neutral 1:3 complex species was extracted in use of more-hydrophobic C8mimTf2N, whereas use of less-hydrophobic C4mimTf2N and C2mimTf2N resulted in competitive extraction of neutral 1:3 and cationic 1:2 complexes. For each of the metals, in addition, similar extraction constants were obtained in these three extraction systems.
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- 2019
35. Genes Located on 18q23 Are Epigenetic Markers and Have Prognostic Significance for Patients with Head and Neck Cancer
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Atsushi Imai, Yuki Misawa, Masato Mima, Kiyoshi Misawa, Kazuya Shinmura, Takeharu Kanazawa, Daiki Mochizuki, Hiroyuki Mineta, Kotaro Morita, and Satoshi Yamada
- Subjects
Oncology ,Cancer Research ,medicine.medical_specialty ,disease-free survival ,promoter methylation ,lcsh:RC254-282 ,Article ,Loss of heterozygosity ,Internal medicine ,medicine ,LOH ,Epigenetics ,Proportional hazards model ,business.industry ,Hazard ratio ,Head and neck cancer ,Methylation ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,medicine.disease ,Head and neck squamous-cell carcinoma ,DNA methylation ,CpG island ,head and neck cancer ,18q23 ,business ,quantitative methylation-specific PCR - Abstract
Loss of heterozygosity (LOH) on chromosome 18q23 is associated with significantly decreased survival in head and neck cancer. In agreement with such tumor suppressive roles, the loss of function of genes located in this region can be achieved through LOH and promotor hypermethylation. In this study, the methylation status of promoters of 18q23 genes in 243 head and neck cancer patients was assessed by quantitative methylation-specific PCR. Promoter methylation was then compared to various clinical characteristics and patient survival. GALR1 and SALL3 promoter methylation correlated with reduced disease-free survival (log-rank test, p = 0.018 and p = 0.013, respectively). Furthermore, based on multivariate Cox proportional hazards analysis, these methylation events were associated with poor disease-free survival, with hazard ratios of 1.600 (95% confidence interval: CI, 1.027&ndash, 2.493, p = 0.038) and 1.911 (95% CI, 1.155&ndash, 3.162, p = 0.012), respectively. By comparison, GALR1 and SALL3 methylation were not prognostic for overall survival in The Cancer Genome Atlas (TCGA) cohort. Our findings suggest that the methylation status of 18q23 genes could serve as important biomarkers for the prediction of clinical outcomes in well-annotated head and neck squamous cell carcinoma cohorts. GALR1 and SALL3 methylation could thus help to facilitate risk stratification for individualized treatment.
- Published
- 2019
36. Primary combined small and squamous cell carcinoma of the hypopharynx: A case report
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Takeharu Kanazawa, Toshihide Iwashita, Daiki Mochizuki, Yuki Misawa, Hiroyuki Mineta, Kiyoshi Misawa, Shiori Endo, Kotaro Morita, Yuichi Hashimoto, Hirotoshi Kikuchi, and Hideya Kawasaki
- Subjects
Oncology ,Cancer Research ,medicine.medical_specialty ,Pathology ,medicine.medical_treatment ,Malignancy ,03 medical and health sciences ,Cytokeratin ,0302 clinical medicine ,Piriform sinus ,Internal medicine ,Carcinoma ,medicine ,Epidermal growth factor receptor ,030223 otorhinolaryngology ,Etoposide ,platelet-derived growth factor receptor α ,biology ,business.industry ,hypopharynx ,Cancer ,Neck dissection ,KIT ,Articles ,medicine.disease ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,biology.protein ,business ,combined small and squamous cell carcinoma ,medicine.drug - Abstract
We herein report a very rare case of combined small-cell carcinoma (SmCC) of the hypopharynx, with a squamous cell carcinoma (SqCC) element. A 74-year-old man presented with a 3-month history of throat pain and hoarseness. On hypopharyngoscopy, a tumor was identified in the right anterior wall of the piriform sinus and, following examination of a biopsy sample, the lesion was diagnosed as SqCC. Total laryngectomy with bilateral neck dissection was performed and the malignancy was diagnosed as combined SmCC. One month after surgery, concomitant chemoradiotherapy with cisplatin and etoposide was administered. Immunohistochemically, the SmCC element was positive for CD56 and Ki-67 (50.2%), whereas the SqCC element was positive for cytokeratin 34βE12 and Ki-67 (47.5%). Furthermore, the SmCC element was positive for KIT and platelet-derived growth factor α (PDGFRα), while the SqCC element was positive for epidermal growth factor receptor (EGFR) and PDGFRα. By genetic analysis, a silent mutation in the PDGFRα gene was recognized. The expression of KIT, PDGFRα and EGFR in this case provided evidence that combined SmCC may be a candidate for molecular-targeted therapy, although further investigations are required.
- Published
- 2016
37. Electrocatalytic Reduction of Free Chlorine at an N,N-Diethvlaniline-grafted Carbon Electrode for Improved Sensitivity in Amperometric Detection
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Naoki Hirayama and Kotaro Morita
- Subjects
010401 analytical chemistry ,Inorganic chemistry ,chemistry.chemical_element ,02 engineering and technology ,021001 nanoscience & nanotechnology ,01 natural sciences ,Amperometry ,Orders of magnitude (mass) ,0104 chemical sciences ,Analytical Chemistry ,Diethylaniline ,Cathodic protection ,chemistry.chemical_compound ,chemistry ,Electrode ,polycyclic compounds ,Chlorine ,0210 nano-technology ,Sensitivity (electronics) ,Carbon - Abstract
The electrocatalytic activity of an N,N-diethylaniline-grafted carbon (DEA/PFC) electrode was utilized to improve the sensitivity in the cathodic detection of free chlorine. Voltammetric curves showed a well-defined cathodic peak of free chlorine on DEA/PFC, lowering the overlap with that of dissolved oxygen. Amperometric measurements were applied for the determination of free chlorine for a concentration range of 4 orders of magnitude. The results showed that measurements of the amperometric response with DEA/PFC can be used as the basis for a simple, accurate, and rapid method to determine free chlorine.
- Published
- 2017
38. Discovery and state transitions of the new Galactic black hole candidate MAXI J1535−571
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Megumi Shidatsu, Kazutaka Yamaoka, Tatehiro Mihara, Nobuyuki Kawai, Hitoshi Negoro, Satoshi Nakahira, Kotaro Morita, T. Kawase, Kazuo Makishima, and Yoshihiro Ueda
- Subjects
High Energy Astrophysical Phenomena (astro-ph.HE) ,Physics ,Photon ,010308 nuclear & particles physics ,FOS: Physical sciences ,Astronomy and Astrophysics ,Astrophysics ,Light curve ,01 natural sciences ,Accretion (astrophysics) ,Amplitude ,Accretion disc ,Space and Planetary Science ,0103 physical sciences ,Peak intensity ,System parameters ,Black-body radiation ,Astrophysics - High Energy Astrophysical Phenomena ,010303 astronomy & astrophysics - Abstract
We report on the detection and subsequent X-ray monitoring of the new Galactic black hole candidate MAXI J1535-571 with the MAXI/GSC. Afterthe discovery on 2017 September 2 made independently with MAXI and the Swift/BAT, the source brightened gradually, and in a few weeks, reached the peak intensity of ~5 Crab, or ~1.6 x 10^{-7} erg cm^{-2} s^{-1} in terms of the 2--20 keV flux. On the initial outburst rise, the X-ray spectrum was described by a power-law model with a photon index of ~2, while after a hard-to-soft transition which occurred on September 18, the spectrum required a disk blackbody component in addition. At around the flux peak, the 2-8 keV and 15-50 keV light curves showed quasi-periodic and anti-correlated fluctuations with an amplitude of 10--20%, on a time scale of ~1-day. Based on these X-ray properties obtained with the MAXI/GSC, we discuss the evolution of the spectral state of this source, and give constraints on its system parameters., Comment: Submitted to Publications of the Astronomical Society of Japan on Apri 3 2018, Accepted by PASJ on July 21 2018
- Published
- 2018
39. Late Engine Activity of GRB 161017A Revealed by Early Optical Observations
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Katsuaki Asano, Nobuyuki Kawai, Makoto Arimoto, Kotaro Morita, S. Harita, Ryosuke Itoh, Yutaro Tachibana, Yoichi Yatsu, T. Fujiwara, Taketoshi Yoshii, and Katsuhiro L. Murata
- Subjects
Physics ,High Energy Astrophysical Phenomena (astro-ph.HE) ,Jet (fluid) ,010308 nuclear & particles physics ,Astrophysics::High Energy Astrophysical Phenomena ,Flux ,FOS: Physical sciences ,Astronomy and Astrophysics ,Context (language use) ,Astrophysics ,Kinetic energy ,Plateau (mathematics) ,01 natural sciences ,Afterglow ,Space and Planetary Science ,0103 physical sciences ,Gamma-ray burst ,Astrophysics - High Energy Astrophysical Phenomena ,010303 astronomy & astrophysics ,Fermi Gamma-ray Space Telescope - Abstract
The long gamma-ray burst GRB 161017A was detected by Fermi and Swift, and its afterglow was observed by the MITSuME 50-cm optical telescope promptly about 50 s after the burst. Early optical observations revealed that the optical lightcurve exhibits a plateau and rebrightening in the early afterglow phase about 500 and 5000 s after the trigger, respectively. By investigating the behavior of the spectral and temporal flux variation, it was found that the plateau and re-brightening cannot be explained in the context of the simple standard afterglow model. These observational features can be explained with two independent refreshed shocks, which indicate the long-acting central engine. We evaluated the physical parameters of the subsequent shells, and we then determined the kinetic energy ratio of the two colliding shells to the leading shell to be roughly 1 and 8, respectively. In addition, two prominent X-ray flares about 200 s after the trigger may be signatures of delayed ejections of the energetic jets responsible for the refreshed shocks. Such late activity of the central engine and X-ray flares play a crucial role in understanding the mechanisms for jet formation and photon emission.
- Published
- 2018
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40. Effect of the Elemental Composition of Precursors from Amino Acids and Their Binary Mixtures on the Photoluminescent Intensity of Carbon Nanodots
- Author
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Kotaro Morita, Haruka Kodama, Shusei Kurusu, and Naoki Hirayama
- Subjects
chemistry.chemical_classification ,Photoluminescence ,Aqueous solution ,010405 organic chemistry ,Carbonization ,Chemistry ,Nitrogen ,010401 analytical chemistry ,Heteroatom ,Osmolar Concentration ,chemistry.chemical_element ,Hydrogen-Ion Concentration ,01 natural sciences ,Sulfur ,Carbon ,0104 chemical sciences ,Analytical Chemistry ,Amino acid ,Luminescent Measurements ,Nanoparticles ,Pyrolytic carbon ,Amino Acids ,Nuclear chemistry - Abstract
We report on the photoluminescent (PL) properties of carbon nanodots (CNDs) doped with nitrogen and sulfur obtained by the pyrolytic carbonization of amino acids as precursors. Prepared CNDs exhibit stable PL emission under a wide variety of aqueous conditions. The results also provided the way to tune a PL intensity of CNDs by varying the amount of heteroatoms in precursors with a binary mixture of amino acids. The PL quantum yields of the obtained CNDs were determined to be from 0.079 to 0.571.
- Published
- 2017
41. Photoluminescent Detection of Nitrite with Carbon Nanodots Prepared by Microwave-assisted Synthesis
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Hirohisa Nagatani, Kotaro Morita, Akane Kobayashi, and Hisanori Imura
- Subjects
Aqueous solution ,Aryl radical ,Inorganic chemistry ,Phenylenediamines ,Chloride ,Carbon ,Analytical Chemistry ,chemistry.chemical_compound ,Perchlorate ,chemistry ,Metals ,Bromide ,Luminescent Measurements ,medicine ,Nanoparticles ,Nanotechnology ,Nitrite ,Microwaves ,Selectivity ,Fluoride ,Nitrites ,medicine.drug - Abstract
A photoluminescent detection method for nitrite with high selectivity and sensitivity using carbon nanodots (CNDs) is demonstrated. The selectivity of nitrite is accomplished by a highly specific diazotization reaction between nitrite and p-phenylenediamine (p-PDA). In the presence of nitrite, p-PDA easily reacts to form the diazonium cation in the acidic aqueous solution. By alkalization of the reaction mixture, diazonium cation of p-PDA was converted to an aryl radical to form aggregated CNDs, which causes the change in the photoluminescent intensity of CNDs. In the present method, nitrite can be selectively detected down to 1 μM over several anions, such as nitrate, perchlorate, sulfate, fluoride, chloride, and bromide at mM levels.
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- 2015
42. Large-scale proteomic analysis of Japanese Black cattle : Part III. Identification of protein biomarker candidates for assessment of carcass traits and meat quality characteristics
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Kouhei Nagai, Sho Uchibori, Takuya Yoshihiro, Naohiko Kobahashi, Haruka Ikegami, Tamako Matsuhashi, Akira Iritani, Kotaro Morita, Yoshitomo Taguchi, Hiromi Kato, Chika Higuchi, Tomoko Amano, Atsushi Takemoto, Etsuko Inoue, and Kazuya Matsumoto
- Subjects
Part iii ,business.industry ,Japanese Black cattle ,Biomarker (medicine) ,Identification (biology) ,Biology ,Beef cattle ,Quality characteristics ,business ,Biotechnology - Published
- 2015
43. Spectroelectrochemical Characterization of Dendrimer–Porphyrin Associates at Polarized Liquid|Liquid Interfaces
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Kotaro Morita, Hisanori Imura, Hirohisa Nagatani, and Hiroki Sakae
- Subjects
Aqueous solution ,Inorganic chemistry ,chemistry.chemical_element ,Free base ,Protonation ,Surfaces and Interfaces ,Zinc ,Molecular encapsulation ,Condensed Matter Physics ,Fluorescence ,Porphyrin ,chemistry.chemical_compound ,chemistry ,Dendrimer ,Polymer chemistry ,Electrochemistry ,General Materials Science ,Spectroscopy - Abstract
Molecular encapsulation of anionic porphyrins in NH2-terminated polyamidoamine (PAMAM) dendrimers and the interfacial behavior of the dendrimer-porphyrin associates were studied at the polarized water|1,2-dichloroethane (DCE) interface. Formation of the ion associates was significantly dependent on the pH condition and on generation of dendrimers. 5,10,15,20-Tetrakis(4-sulfonatophenyl)porphyrin (ZnTPPS4-) associated with the positively charged fourth-generation (G4) PAMAM dendrimer was highly stabilized in acidic aqueous solution without protolytic demetalation in a wide range of pH values (pH > 2). In contrast to the zinc(II) complex, the free base porphyrin (H2TPPS4-) was readily protonated under acidic conditions even in the presence of the dendrimers. In addition, the J-aggregates of diprotonated species, (H4TPPS2-) n, were preferably formed on the dendrimer. The interfacial mechanism of the dendrimer-porphyrin associates was analyzed in detail by potential-modulated fluorescence (PMF) spectroscopy. PMF results indicated that the dendrimers incorporating porphyrin molecules were transferred across the positively polarized water|DCE interface via adsorption step, whereas the transfer responses of the porphyrin ions released from the dendrimers were observed at negatively polarized conditions. A negative shift of the transfer potential of porphyrin ions compared to the intrinsic transfer potential was apparently observed for each ion association system. The ion association stability between the dendrimer and the porphyrin molecules could be estimated from a negative shift of the transfer potential. ZnTPPS4- exhibited relatively strong interaction with the higher generation dendrimer, whereas H2TPPS4- was less effectively associated with the dendrimers. © 2014 American Chemical Society.
- Published
- 2014
44. The Extraction of Copper(I) Ions with Heterocyclic Bidentate Amines in the Presence of Glutathione
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Kotaro Morita, Kazuki Nakano, and Hisanori Imura
- Subjects
chemistry.chemical_compound ,Denticity ,chemistry ,General Chemical Engineering ,Extraction (chemistry) ,Inorganic chemistry ,chemistry.chemical_element ,General Chemistry ,Glutathione ,Copper ,Ion - Abstract
Copper(I) ions are generally unstable in aqueous solution and readily disproportionate to copper(II) and copper(0). In this work, copper(I) is formed and stabilized under aerobic conditions by the addition of glutathione (GSH) which acts as a reducing and complexing agent. The extraction of Cu(I) with heterocyclic bidentate amines such as 2,9-dimethyl-1,10-phenanthroline (dmp), 2,9-dimethyl-4,7-diphenyl- 1,10-phenanthroline, and 2,2’-biquinoline has been studied in the presence of GSH.The formation of the Cu(I)-GSH complex in the aqueous solution was confirmed by spectrophotometry under aerobic conditions.Time-course measurements of the absorbance indicated that the Cu(I)-GSH complex retained stability toward re-oxidation by air for at least 6 h in the presence of a 10-fold excess of GSH at pH 5-7.The quantitative extraction of copper(I) was accomplished with 5.0 × 10−4 M dmp in chloroform or 1,2-dichloroethane in the presence of 5.0 × 10−4 M GSH and 0.10 M ClO4− at pH 3-6. The extracted species was found to be Cu(dmp)2ClO4 by the substoichiometric extraction method.
- Published
- 2014
45. Which treatment strategies are the most promising for locally advanced resectable human papillomavirus-associated oropharyngeal cancers?
- Author
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Tetsuro Onitsuka, Tomoyuki Kamijo, Yusuke Onozawa, Yoshiyuki Iida, Sadayuki Kawai, Masahiro Nakagawa, Noriko Hamaguchi, Hirofumi Ogawa, Tomoya Yokota, Takashi Mukaigawa, Yukio Nishiya, Tsuyoshi Onoe, Kotaro Morita, Satoshi Hamauchi, and Hiromichi Shirasu
- Subjects
Oncology ,Cancer Research ,medicine.medical_specialty ,Standard of care ,business.industry ,Locally advanced ,Internal medicine ,Medicine ,Treatment strategy ,Oropharyngeal squamous cell carcinoma ,Human papillomavirus ,business ,Oropharyngeal Cancers - Abstract
e17556 Background: The standard of care for oropharyngeal squamous cell carcinoma (OPSCC) is surgical (S) or non-surgical (NS) approach including chemoradiation (CRT). However, CRT is associated with significant long-term toxicity. Human papillomavirus (HPV) status are associated with improved prognosis for patients (pts) with OPSCC. The aim of this study was to explore the most promising treatment strategy with maintaining survival outcomes while improving QOL for locally advanced resectable HPV-positive OPSCC. Methods: A retrospective analysis of 96 pts with locally advanced resectable HPV-positive OPSCC in Shizuoka Cancer Center between 2004 and 2018 was performed. p16 immunohistochemistry was used to determine HPV tumor status. Clinical characteristics, acute and late toxicities, nutritional support, and survival were compared by treatment modalities. In pts who received S, surgical procedure and histological findings of the surgical specimens were additionally compared between pts who underwent upfront surgery (US) and those who did induction chemotherapy followed by surgery (ICT-S). Results: The median age was 62 years, with the majority having tonsil and base of the tongue as primary site. Thirty-six pts (38%) were current smokers, and 39 (41%) were former smokers. As an initial treatment, 62 (64.6%) and 34 (35.4%) pts underwent S and NS, respectively. Aspiration pneumonia more frequently occurred in NS (41.2%) than in S (8.1%) (p < 0.01). Nutritional support by gastrostomy tube or total parenteral nutrition was required in 20 pts (58.8%) of NS, compared with 15 pts (24.2%) of S (p < 0.01). S showed a trend toward longer overall survival (OS) than NS [HR = 0.204, p = 0.052], while progression free survival (PFS) was comparable between the groups. Of all S, 48 (50.0%) and 14 (14.6%) underwent US and ICT-S, respectively. Transoral surgery was performed in 78.6% of ICT-S, compared with 20.8% of US (p < 0.01). Histological examination of the surgical specimens revealed that positive surgical margins, involvement of ≥ 2 regional lymph nodes, and positive extracapsular extension were present in 7.1, 35.7, and 35.7% of ICT-S, compared with 31.3, 58.3, and 45.8% of US, respectively (N.S.). Pathologic complete response in the primary site and lymph nodes occurred in 43 % of ICT-S. Both OS and PFS was comparable between the groups. Conclusions: Our results suggest the impact of surgical approach on reduced long-term toxicity for HPV-positive OPSCC. ICT followed by surgery might be promising novel treatment strategy.
- Published
- 2019
46. A case of closure of a pharyngo-tracheal fistula designed to restore speech after total laryngectomy
- Author
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Takashi Yamatodani, Goro Takahashi, Daiki Mochizuki, Hiroyuki Mineta, Seiji Hosokawa, Kotaro Morita, Yoshinori Takizawa, Kiyoshi Misawa, and Kenichi Sugiyama
- Subjects
Laryngectomy ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Closure (topology) ,Medicine ,business ,Surgery ,Tracheal fistula - Published
- 2013
47. Valence discriminative detection of metal cations by a chromotropic acid-grafted glassy carbon electrode
- Author
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Kotaro Morita, Hisanori Imura, Kenichi Shibata, Hirohisa Nagatani, and Naoki Hirayama
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Lanthanide ,Chemistry ,Inorganic chemistry ,Electrochemistry ,Chromotropic acid ,Redox ,Analytical Chemistry ,Metal ,chemistry.chemical_compound ,Covalent bond ,visual_art ,Electrode ,visual_art.visual_art_medium ,Moiety - Abstract
Covalent grafting of chromotropic acid (CA) moiety to a glassy carbon electrode was performed by electrochemical reduction of the corresponding diazonium cation generated in situ. Grafted electrodes were subjected to the electrochemical detection of multivalent cations using Fe(CN)6 3-/4- as an electrochemical probe molecule. In the absence of metal cations, redox reaction of the anionic probe was depressed by electrostatic repulsion between the probe and negatively charged CA moieties on the electrode surface. Binding of tetravalent cations such as Zr(IV) and Hf(IV) and trivalent cations such as Al(III) and lanthanide(III) to the CA moiety on the electrode surface resulted in an increase in the current intensity of the probe due to a decrease in electrostatic repulsion. Highly selective detection of the tetravalent cations was achieved in the micromolar concentration range at pH 1.0. © The Japan Society for Analytical Chemistry.
- Published
- 2013
48. Grafting of phenylboronic acid on a glassy carbon electrode and its application as a reagentless glucose sensor
- Author
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Norio Teramae, Akira Yamaguchi, Naoki Hirayama, Kotaro Morita, and Hisanori Imura
- Subjects
Phenylboronic acid ,General Chemical Engineering ,Analytical chemistry ,Impedance spectroscopy ,Glassy carbon ,Grafting ,Electrochemistry ,Redox ,Analytical Chemistry ,Dielectric spectroscopy ,chemistry.chemical_compound ,Glucose ,chemistry ,Electrode ,In situ generated diazonium cation ,Cyclic voltammetry ,Nuclear chemistry - Abstract
金沢大学理工研究域物質化学系, Phenylboronic acid (PBA) was covalently grafted to the surface of glassy carbon (GC) electrodes using electrochemical reduction of in situ generated diazonium cation. The grafting of GC surfaces was controlled by varying both the concentration of precursor 3-aminophenylboronic acid and the number of potential cycling during the grafting procedure. Cyclic voltammetry (CV) and eletrochemical impedance spectroscopy (EIS) were used to confirm the grafting of the PBA group to the GC surface and formation of multilayer. The barrier properties of the grafted GC electrodes were studied in the presence of a redox probe such as Fe (CN)63 - / 4 - by CV. Additionally, the resultant PBA multilayer on the GC electrode was applied for glucose detection utilizing the EIS technique in the presence of a redox probe molecule. Then, the complexation ability of the grafted layers with glucose was also confirmed as an increase of total impedance at non-faradic EIS measurement. © 2010 Elsevier B.V. All rights reserved.
- Published
- 2011
49. Effect of organic cations and solvents on the ion-pair extraction of boric acid with salicyl alcohol
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Keisuke Morita, Kotaro Morita, Naoki Hirayama, and Hisanori Imura
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Boric acid ,chemistry.chemical_compound ,Chemistry ,Salicyl alcohol ,General Chemical Engineering ,Extraction (chemistry) ,Inorganic chemistry ,Organic chemistry ,General Chemistry ,Ion pairs - Abstract
Ion-pair extraction of boric acid with salicyl alcohol (H2sal) has been studied using several organic cations such as trioctylmethylammonium chloride (TOMAC1), tetrahexylammonium bromide (Ph 4PBr), and tetraphenylphosphonium bromide (Ph 4PBr) in various solvents. The extractability of boric acid was strongly dependent on the organic cations and solvents used and decreased in the order TOMAC1 > Hex 4NBr>> Ph 4PBr in almost all solvents for which the order was o-dichlorobenzene > chlorobenzene > toluene > 1,2-dichloroethane > hexane > chloroform > methyl isobutyl ketone for TOMAC1. The extracted species was found to be TOMA + B(sal) 2 in toluene from equilibrium analysis.
- Published
- 2011
50. Highly Selective Synergism for the Extraction of Lanthanoid(III) Ions with β-Diketones and Trioctylphosphine Oxide in an Ionic Liquid
- Author
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Hisanori Imura, Hitomi Takagi, Hiroyuki Okamura, Taku Isomura, Kotaro Morita, and Hirohisa Nagatani
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Lanthanide ,Ion exchange ,Chemistry ,Ligand ,Extraction (chemistry) ,Inorganic chemistry ,Cationic polymerization ,lanthanoid(III) ,Ionic liquid ,trioctylphosphine oxide ,Analytical Chemistry ,chemistry.chemical_compound ,β-diketone ,synergistic effect ,Imide ,Trioctylphosphine oxide - Abstract
Selective synergism for the extraction of lanthanoids(III) (Ln) with β-diketones such as 2-thenoyltrifluoroacetone, 2-naphthoyltrifluoroacetone, and benzoylacetone has been investigated in the presence of trioctylphosphine oxide as a hydrophobic neutral ligand in 1-butyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide as an ionic liquid. The extractability of heavier Ln was remarkably enhanced, resulting in a significant improvement in the separation of Ln. It was found that the present synergism is ascribed to the formation of cationic ternary complexes, followed by ion exchange into the ionic liquid.
- Published
- 2014
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