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48 results on '"Kouam, Simeon Fogue"'

2. LC-MS Identification and Preliminary Pharmacological Study of the Aqueous and Ethanol Extracts from Combretum glutinosum Perr ex DC. (Combretaceae)

Author

Toklo, Placide Mahougnan, Ahomadegbe, Mathias Amour, Dah-Nouvlessounon, Durand, Jouda, Jean-Bosco, Tchegnitegni, Billy Toussie, Wouamba, Steven Collins Njonte, Ahoton, Djidénou, Assogba, Mahoudo Fidèle, Tchamgoue, Joseph, Lenta, Bruno Ndjakou, Kouam, Simeon Fogue, Baba-Moussa, Lamine, Ladekan, Eléonore Chikani Yayi, and Gbenou, Joachim Djimon

Published
2023
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4. In Vitro and Molecular Docking Evaluation of the Anticholinesterase and Antidiabetic Effects of Compounds from Terminalia macroptera Guill. & Perr. (Combretaceae)

Author

Feunaing, Romeo Toko, primary, Tamfu, Alfred Ngenge, additional, Gbaweng, Abel Joel Yaya, additional, Kucukaydin, Selcuk, additional, Tchamgoue, Joseph, additional, Lannang, Alain Meli, additional, Lenta, Bruno Ndjakou, additional, Kouam, Simeon Fogue, additional, Duru, Mehmet Emin, additional, Anouar, El Hassane, additional, Talla, Emmanuel, additional, and Dinica, Rodica Mihaela, additional

Published
2024
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12. Potentiation effect of mallotojaponin B on chloramphenicol and mode of action of combinations against Methicillin-resistant Staphylococcus aureus

Author

Nguena-Dongue, Branly-Natalien, primary, Tchamgoue, Joseph, additional, Ngandjui Tchangoue, Yvan Anderson, additional, Lunga, Paul Keilah, additional, Toghueo, Kouipou Rufin Marie, additional, Zeuko`o, Menkem Elisabeth, additional, Melogmo, Yanick Kevin Dongmo, additional, Tchouankeu, Jean Claude, additional, Kouam, Simeon Fogue, additional, and Fekam, Boyom Fabrice, additional

Published
2023
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13. Crystal Structure, Vibrational Spectroscopy, Dft Calculated Electronic Properties and Molecular Docking Study of Pachypodostyflavone: A Potent Anti-Onchocerca

Author

Mountessou, Bel Youssouf Gbetnkom, primary, Ngouonpe, Alain W., additional, Stammler, Hans-Georg, additional, Akintemi, Eric O., additional, Mbobda, Alexis Sylvain Wafo, additional, Kouam, Simeon Fogue, additional, Tchouankeu, Jean Claude, additional, Lenta, Bruno Ndjakou, additional, Sewald, Norbert, additional, Singh, Thishana, additional, and Mbouombouo, Ibrahim Ndassa, additional

Published
2023
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14. Polyoxygenated Stigmastane-Type Steroids from Vernonia kotschyana Sch. Bip. ex Walp. and Their Chemophenetic Significance

Author

Tseme Wandji, Nadine, Bitchagno, Gabin Thierry M., Mawabo Kamga, Isabelle, Tchamgoue, Joseph, Nkenfou, Celine Nguefeu, Lenta, Bruno Ndjakou, Sewald, Norbert, and Kouam, Simeon Fogue

Subjects
antibacterial activity, structure elucidation, Asteraceae, stigmastanes, chemophenetic significance, Vernonia kotschyana
Abstract

Four polyoxygenated stigmastanes (1–4) alongside known analogues (7–8) and flavonoids (5–6) were isolated from a dichloromethane/methanol (1:1, v/v) extract of the whole plant of Vernonia kotschyana Sch. Bip. ex Walp. (Asteraceae). Their structures were determined by means of spectroscopic and spectrometric analysis. The relative stereochemistry of the new compounds was established and confirmed via biosynthesis evidence and cyclization of 1 under acidic conditions. A plausible biosynthetic pathway to the new compounds and the chemophenetic significance of the isolated constituents were also discussed. The crude extract, fractions, and compounds (1–3) were assessed for their antibacterial activity against five highly prevalent bacterial strains. The fractions and compounds showed low to moderate activity with minimal inhibitory concentrations (MICs) > 125 µg/mL.

Published
2023
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17. Atricephenols A and B, two phenolic compounds from Indigofera atriceps Hook.f. (Fabaceae).

Author

Mouafon, Iliassou Lah, Mountessou, Bel Youssouf Gbetnkom, Lateef, Mehreen, Tchamgoue, Joseph, Shaiq Ali, Muhammad, Tchouankeu, Jean Claude, Green, Ivan Robert, Ngadjui, Bonaventure Tchaleu, and Kouam, Simeon Fogue

Subjects
PHENOLS, INDIGOFERA, LEGUMES, METABOLITES, SALMONELLA typhi, THIOUREA
Abstract

The phytochemical investigation of a previously unstudied species of the genus Indigofera, I. atriceps Hook.f. was undertaken and two new phenolic compounds, atricephenols A (1) and B (2) were isolated, along with nine known secondary metabolites viz., (-)-melilotocarpan D (3), genistein (4), melilotocarpan A (5), maackiain (6), p-hydroxybenzaldehyde (7), bornesitol (8), β-sitosterol (9), sitosterol-3-O-β-D-glucopyranoside (10) and stigmasterol-3-O-β-D-glucopyranoside (11). Their structures were elucidated by extensive NMR spectroscopic analyses and HRESIMS, and by comparing their data with those reported in the literature. Compounds 1, 4, 7–11 were tested for their antibacterial efficacies and for their potential to inhibit the enzyme urease. Compounds 7 and 9 showed significant antibacterial activity against Salmonella typhi (ZOIs of 13 and 15 mm, respectively), while the best urease inhibition was measured for compound 9 with an IC50 value of 18.6 µM, which is higher than that of the potent inhibitor, thiourea (IC50 = 21.5 µM). [ABSTRACT FROM AUTHOR]

Published
2023
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20. X-Ray Crystal Structure, Spectroscopic Analysis, Computational Quantum Chemical and Molecular Docking Studies of a Naturally Occurring Sesquiterpene Lactone: Costunolide for Inhibitor Capacity Against the Main Protease of the Parasitic Worm Onchocerca Volvulus

Author

Mountessou, Bel Youssouf Gbetnkom, primary, Mbobda, Alexis Sylvain Wafo, additional, Stammler, Hans-Georg, additional, Akintemi, Eric O., additional, Mbah, Maraf Bake, additional, Happi, Gervais Mouthé, additional, Kouam, Simeon Fogue, additional, Lenta, Bruno Ndjakou, additional, Sewald, Norbert, additional, Singh, Thishana, additional, and Mbouombouo, Ibrahim Ndassa, additional

Published
2022
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25. Pachypodostyflavone, a New 3-methoxy Flavone and Other Constituents with Antifilarial Activities from the Stem Bark of Duguetia staudtii

Author

Mbobda, Alexis Sylvain Wafo, additional, Ngouonpe, Alain Wembe, additional, Happi, Gervais Mouthé, additional, Mountessou, Bel Youssouf G., additional, Monya, Elvis, additional, Jouda, Jean-Bosco, additional, Toussie, Billy Tchegnitegni, additional, Lenta, Bruno Ndjakou, additional, Sewald, Norbert, additional, Kouam, Simeon Fogue, additional, and Tchouankeu, Jean Claude, additional

Published
2021
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26. Two new triterpenoid fatty acid esters from Schefflera barteri Harms (Araliaceae)§.

Author

Mbougnia, Judith Flore T., Bitchagno, Gabin Thierry M., Wouamba, Steven Collins N., Jouda, Jean-Bosco, Awouafack, Maurice Ducret, Tene, Mathieu, Lenta, Bruno Ndjakou, Kouam, Simeon Fogue, Tane, Pierre, and Sewald, Norbert

Subjects
FATTY acid esters, ARALIACEAE, GRAM-positive bacteria, CANCER cells, COLON cancer
Abstract

Two new fatty acid esters of triterpenoids (1–2) together with eleven known compounds (3–13) were obtained after investigation of the CH2Cl2-MeOH (1:1) crude extract from the leaves of Schefflera barteri Harms. All these compounds (1–13) were isolated for the first time from this plant among which compounds 3, 4, 6 and 9–13 were also isolated from the genus Schefflera for the first time. The structures of the isolated compounds were elucidated by analyses of their spectroscopic data (1D and 2D NMR, and MS). The antibacterial and cytotoxic activities of crude extracts, fractions and compounds (1, 2, 5, 6, 8 and 9) were investigated against both Gram-negative and Gram-positive bacteria strains as well as on human cervix carcinoma and colon adenocarcinoma cancer cell lines, respectively. They showed weak to significant activity towards the strains and malignant cells used. [ABSTRACT FROM AUTHOR]

Published
2022
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30. Antibacterial phloroglucinols derivatives from the leaves of Mallotus oppositifolius (Geisler) Müll. Arg. (Euphorbiaceae)

Author

Tchangoue, Yvan Anderson Ngandjui, primary, Tchamgoue, Joseph, additional, Lunga, Paul Keilah, additional, Knepper, Janosch, additional, Paltinean, Ramona, additional, Ibrom, Kerstin, additional, Crișan, Gianina, additional, Kouam, Simeon Fogue, additional, Ali, Muhammad Shaiq, additional, and Schulz, Stefan, additional

Published
2020
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33. A lanostane aldehyde from Momordica charantia

Author

Panlilio, Bella G., Macabeo, Allan Patrick G., Knorn, Matthias, Kohls, Paul, Richomme, Pascal, Kouam, Simeon Fogue, Gehle, Dietmar, Krohn, Karsten, Franzblau, Scott G., Zhang, Qingwen, and Aguinaldo, Ma. Alicia M.

Published
2012
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37. Tramadol—A True Natural Product?

Author

Kusari, Souvik, primary, Tatsimo, Simplice Joel N., additional, Zühlke, Sebastian, additional, Talontsi, Ferdinand M., additional, Kouam, Simeon Fogue, additional, and Spiteller, Michael, additional

Published
2014
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43. A new dimeric naphtho-γ-pyrone from an endophytic fungus Aspergillus niger AKRN associated with the roots of Entandrophragma congoënse collected in Cameroon.

Author

Kouam, Simeon Fogue, Happi, Gervais M., Talontsi, Ferdinand M., Zühlke, Sebastian, Spiteller, Michael, Nkenfou, Céline N., Longo, Frida, and Douanla-Meli, Clovis

Subjects
*ASPERGILLUS niger, *ENDOPHYTIC fungi, *ENTANDROPHRAGMA, *MELIACEAE
Abstract

A new dimeric naphtho-γ-pyrone, 2-hydroxydihydronigerone (1), along with five compounds, nigerone (2), pyrophen (3), kojic acid (4), 4-(hydroxymethyl)-5-hydroxy-2H-pyran-2-one (5), and p-hydroxyphenylacetic acid (6), was isolated from an endophytic fungus Aspergillus niger AKRN associated with the roots of Entandrophragma congoënse. The structure of the new compound has been elucidated using spectroscopic data including 1D and 2D NMR as well as the high-resolution mass spectrometry. Compounds 1–5 showed weak antimicrobial activity on five selected Gram-negative bacteria, namely Enterobacter aerogenes (CM64), Enterobacter cloacae (BM67), Klebsiella pneumonia (K2), and Escherichia coli (ATCC8739 and ATCC10536). [ABSTRACT FROM AUTHOR]

Published
2015
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44. A new dimeric naphtho-γ-pyrone from an endophytic fungus Aspergillus nigerAKRN associated with the roots of Entandrophragma congoënsecollected in Cameroon

Author

Happi, Gervais M., Kouam, Simeon Fogue, Talontsi, Ferdinand M., Nkenfou, Céline N., Longo, Frida, Zühlke, Sebastian, Douanla-Meli, Clovis, and Spiteller, Michael

Abstract

A new dimeric naphtho-γ-pyrone, 2-hydroxydihydronigerone (1), along with five compounds, nigerone (2), pyrophen (3), kojic acid (4), 4-(hydroxymethyl)-5-hydroxy-2H-pyran-2-one (5), and p-hydroxyphenylacetic acid (6), was isolated from an endophytic fungus Aspergillus nigerAKRN associated with the roots of Entandrophragma congoënse. The structure of the new compound has been elucidated using spectroscopic data including 1D and 2D NMR as well as the high-resolution mass spectrometry. Compounds 1–5showed weak antimicrobial activity on five selected Gram-negative bacteria, namely Enterobacter aerogenes(CM64), Enterobacter cloacae(BM67), Klebsiella pneumonia(K2), and Escherichia coli(ATCC8739 and ATCC10536).

Published
2015
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45. Antiplasmodial and Cytotoxic Triterpenoids from the Bark of the Cameroonian Medicinal Plant Entandrophragma congoënse

Author

Happi, Gervais Mouthé, Kouam, Simeon Fogue, Talontsi, Ferdinand Mouafo, Lamshöft, Marc, Zühlke, Sebastian, Bauer, Jonathan O., Strohmann, Carsten, and Spiteller, Michael

Abstract

Eight new triterpenoids, prototiamins A–G (1–6, 9) and seco-tiaminic acid A (10), were isolated along with four known compounds from the bark of Entandrophragma congoënse. Their structures were elucidated by means of HRMS and different NMR techniques and chemical transformations. Assignments of relative and absolute configurations for the new compounds were achieved using NOESY experiments and by chemical modification including the advanced Mosher’s method. Additionally, the structure and relative configuration of compound 3were confirmed by single-crystal X-ray diffraction analysis. Compounds 1, 3, and 5displayed significant in vitro antiplasmodial activity against the erythrocytic stages of chloroquine-sensitive Plasmodium falciparumstrain NF54. Prototiamin C (3) was the most potent of the compounds isolated, with an IC50value of 0.44 μM. All compounds tested showed low cytotoxicity for the L6 rat skeletal myoblast cell line.

Published
2015
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46. A New Dimeric Naphtho-γ-pyrone from an Endophytic Fungus Aspergillus niger AKRN Associated with the Roots of Entandrophragma congoense Collected in Cameroon.

Author

Happi, Gervais M., Kouam, Simeon Fogue, Talontsi, Ferdinand M., Nkenfou, Celine N., Longo, Frida, Zuehlke, Sebastian, Douanla‐Meli, Clovis, and Spiteller, Michael

Subjects
*DIMERIC ions, *ASPERGILLUS
Abstract

[isolation and structure elucidation of 2-hydroxydihydronigerone (I)]. [ABSTRACT FROM AUTHOR]

Published
2016
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47. Two new triterpenoid fatty acid esters from Schefflera barteri Harms (Araliaceae) § .

Author

Mbougnia JFT, Bitchagno GTM, Wouamba SCN, Jouda JB, Awouafack MD, Tene M, Lenta BN, Kouam SF, Tane P, and Sewald N

Subjects
Esters analysis, Fatty Acids analysis, Female, Humans, Plant Extracts chemistry, Plant Leaves chemistry, Araliaceae chemistry, Triterpenes chemistry
Abstract

Two new fatty acid esters of triterpenoids ( 1 - 2 ) together with eleven known compounds ( 3 - 13 ) were obtained after investigation of the CH 2 Cl 2 -MeOH (1:1) crude extract from the leaves of Schefflera barteri Harms. All these compounds ( 1 - 13 ) were isolated for the first time from this plant among which compounds 3 , 4 , 6 and 9 - 13 were also isolated from the genus Schefflera for the first time. The structures of the isolated compounds were elucidated by analyses of their spectroscopic data (1D and 2D NMR, and MS). The antibacterial and cytotoxic activities of crude extracts, fractions and compounds ( 1 , 2 , 5 , 6 , 8 and 9 ) were investigated against both Gram-negative and Gram-positive bacteria strains as well as on human cervix carcinoma and colon adenocarcinoma cancer cell lines, respectively. They showed weak to significant activity towards the strains and malignant cells used.

Published
2022
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48. Tramadol--a true natural product?

Author

Kusari S, Tatsimo SJ, Zühlke S, Talontsi FM, Kouam SF, and Spiteller M

Subjects
Biological Products chemistry, Cameroon, Reference Standards, Tandem Mass Spectrometry, Tramadol chemistry, Biological Products isolation & purification, Plant Roots chemistry, Rubiaceae chemistry, Tramadol isolation & purification
Abstract

We have independently investigated the source of tramadol, a synthetic analgesic largely used for treating moderate to severe pain in humans, recently found in the roots of the Cameroonian medicinal plant, Nauclea latifolia. We found tramadol and its three major mammalian metabolites (O-desmethyltramadol, N-desmethyltramadol, and 4-hydroxycyclohexyltramadol) in the roots of N. latifolia and five other plant species, and also in soil and local water bodies only in the Far North region of Cameroon. The off-label administration of tramadol to cattle in this region leads to cross-contamination of the soil and water through feces and urine containing parent tramadol as well as tramadol metabolites produced in the animals. These compounds can then be absorbed by the plant roots and also leached into the local water supplies. The presence of tramadol in roots is, thus, due to an anthropogenic contamination with the synthetic compound., (© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Published
2014
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