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161 results on '"Kounali, Daphne"'

1. Defatting of donor transplant livers during normothermic perfusion—a randomised clinical trial: study protocol for the DeFat study

Author

Abbas, Syed Hussain, Ceresa, Carlo D. L., Hodson, Leanne, Nasralla, David, Watson, Christopher J. E., Mergental, Hynek, Coussios, Constantin, Kaloyirou, Fotini, Brusby, Kerrie, Mora, Ana, Thomas, Helen, Kounali, Daphne, Keen, Katie, Pollok, Joerg-Matthias, Gaurav, Rohit, Iype, Satheesh, Jassem, Wayel, Perera, M. Thamara PR, Hakeem, Abdul Rahman, Knight, Simon, and Friend, Peter J.

Published
2024
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3. Desmopressin for prevention of bleeding for thrombocytopenic, critically ill patients undergoing invasive procedures: A randomised, double‐blind, placebo‐controlled feasibility trial.

Author

Desborough, Michael J. R., Laing, Emma, Kounali, Daphne, Mora, Ana, Hodge, Renate, Martin, Siobhan, Thomas, Helen, Hudson, Cara, Parsons, Joseph, Shah, Akshay, Hutton, Paula, Parke, Tim, Wise, Matthew P., Morgan, Matthew, McKechnie, Stuart, and Stanworth, Simon J.

Published
2024
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7. The clinical effectiveness of sertraline in primary care and the role of depression severity and duration (PANDA): a pragmatic, double-blind, placebo-controlled randomised trial

Author

Lewis, Gemma, Duffy, Larisa, Ades, Anthony, Amos, Rebekah, Araya, Ricardo, Brabyn, Sally, Button, Katherine S, Churchill, Rachel, Derrick, Catherine, Dowrick, Christopher, Gilbody, Simon, Fawsitt, Christopher, Hollingworth, William, Jones, Vivien, Kendrick, Tony, Kessler, David, Kounali, Daphne, Khan, Naila, Lanham, Paul, Pervin, Jodi, Peters, Tim J, Riozzie, Derek, Salaminios, George, Thomas, Laura, Welton, Nicky J, Wiles, Nicola, Woodhouse, Rebecca, and Lewis, Glyn

Published
2019
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8. Early growth and coronary heart disease

Author

Kounali, Daphne

Subjects
616.123071
Abstract

The proposal that nutrition is a central stimulus for programming of susceptibility to adult disease is the motivation for the present investigation. We use the weight and height growth trajectories from the first two years of life of 4630 men who were born between 1934 and 1944 at the Helsinki University Central Hospital and their records of death and hospital admissions. We consider the problem of associating early growth in weight and height with coronary heart disease (CHD) occurrence later in life as a means of understanding the natural history of the disease. We proceed with estimation by employing mixed effects modelling. We perform statistical inference using the Bayesian approach and proceed with computations using Markov Chain Monte Carlo methodology. We reproduce known associations of increased CHD risk with low socio-economic status, low birth weight, thinness, small head circumference and reduced average weight growth and increased placental weight and maternal body mass index. However, the associated effect estimates are accompanied by considerable uncertainty and are sensitive to conditioning on social status with the exception of thinness at birth and maternal body mass index. We find modest but systematic differences in the weight attained between these two groups at birth and after the first year of life in favour of the CHD-free group. We do not find any evidence to support a deletirious effect of accelerated postnatal growth on later CHD health. On the contrary, we find that children who later suffered from CHD had lower weight gains at two months and lower weight gains according to their height after the third month. We conclude that nutrition related factors underlying human growth as well as CHD aetiology could explain these associations and support the plausibility of the fetal origins hypothesis.

Published
2006

12. Simultaneous Synthesis of Treatment Effects and Mapping to a Common Scale: An Alternative to Standardisation

Author

Ades, A. E., Lu, Guobing, Dias, Sofia, Mayo-Wilson, Evan, and Kounali, Daphne

Abstract

Objective: Trials often may report several similar outcomes measured on different test instruments. We explored a method for synthesising treatment effect information both within and between trials and for reporting treatment effects on a common scale as an alternative to standardisation Study design: We applied a procedure that simultaneously estimates a pooled treatment effect and the "mapping" ratios between the treatment effects on test instruments in a connected network. Standardised and non-standardised treatment effects were compared. The methods were illustrated in a dataset of 22 trials of selective serotonin reuptake inhibitors against placebo for social anxiety disorder, each reporting treatment effects on between one and six of a total nine test instruments. Results: Ratios of treatment effects on different test instruments varied from trial to trial, with a coefficient of variation of 18% (95% credible interval 11-29%). Standardised effect models fitted the data less well, and standardised treatment effects were estimated with less relative precision than non-standardised effects and with greater relative heterogeneity. Conclusion: Simultaneous synthesis of treatment effects and mapping to a common scale make fewer assumptions than standardising by dividing effects by the sample standard deviation, allow results to be reported on a common scale, and deliver estimates with superior relative precision.

Published
2015
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15. Minimal Clinically Important Differences on Routine Psychological Therapy Outcome Measures for Patients with Depression or Anxiety

Author

Buckman, Joshua, Saunders, Rob, Button, Katherine, Kounali, Daphne, Leibowitz, Judy, Dunn, Barney, Stringaris, Argyris, Pilling, Stephen, and Lewis, Glyn

Subjects
Cognitive Behavioral Therapy, Mental and Social Health, Medicine and Health Sciences, Psychiatry and Psychology, Psychiatric and Mental Health, sense organs, Psychoanalysis and Psychotherapy
Abstract

This is a protocol detailing the planned analyses for a number of studies within a single project. The studies are related by drawing on the same sample or subsets of the overall sample, and sharing one of two broad aims (detailed below). The purpose of the overall project is to investigate a patient-centred metric of change during routinely delivered psychological therapy for depression or anxiety disorders among adults in Improving Access to Psychological Therapies (IAPT) services. To do this, the project aims to calculate minimum clinically important differences (MCIDs) for symptom change before and once ending therapy; that is, the smallest amount of change pre-post treatment needed on a measure of symptoms for it to be deemed important by a patient.

Published
2022
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18. Pupil Composition and Accountability: An Analysis in English Primary Schools

Author

Lauder, Hugh, Kounali, Daphne, Robinson, Tony, and Goldstein, Harvey

Abstract

This paper examines the role of social class and prior achievement composition effects on pupils' progress and the judgements made about school performance. It finds that there are small but significant compositional effects on pupil progress raising questions about how pupils can best be allocated to schools. Comparisons between the official contextual value added model and one that includes composition variables show that school rankings are significantly changed in the latter suggesting that official value added analyses are misleading. This study, therefore, poses a fundamental challenge to policy makers over the determinants of pupil progress and school performance and the way schools are judged, pointing to the need for a re-appraisal of policy relating to these matters. (Contains 4 figures and 8 tables.)

Published
2010
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19. Report of the Council for 2010

Author

Isham, Valerie, Dougherty, Martin, Simpson, Sarah, Lewis, Trevor, Senn, Stephen, Garratt, Andrew, Leyland, Jill, Aitken, Colin, Smith, Ron, Griffiths, Martin, Gentry, Paul, Emmerson, Nicola, Garrett, Andy, Goodall, Gerald, McColl, John, Bidgood, Penny, Hurcomb, Debra, Davies, Neville, Forster, Jon, Owen, Martin, Duckworth, Frank, Champkin, Julian, Sweetland, Mary, Church, Jenny, Murray, Liam, Grossman, Heiko, Chandler, Richard, Barnett, Vic, Stander, Julian, Walters, Stephen, Harris, Liz, Craggs, Carolyn, Samworth, Richard, Fielding, Antony, Lannon, Jenny, Martin, David, Marchant, Maurice, Henderson, G. Robin, Kounali, Daphne, Spowage, Mairi, Torsney, Ben, Hall, Malcolm, Sperrin, Matthew, Baxter, Paul, Logsdon, John, Bonnett, Laura, Gordon, Alan, Hopewell, Jemma, Hilditch, Sara, Eales, John, Kimani, Peter, Grimes, Tom, Vincent, Sayer, and Elliott, Helen

Published
2011

21. Report of the Council for 2009

Author

Hand, David J., Dougherty, Martin, Simpson, Sarah, Goodall, Gerald, Lewis, Trevor, Bird, Sheila, Garratt, Andrew, Leyland, Jill, Aitken, Colin, Goddard, Ivor, Smith, Ron, Gentry, Paul, Bowman, Adrian, Emmerson, Nicola, Garrett, Andy, McColl, John, Bidgood, Penny, Hurcomb, Debra, Owen, Martin, Henderson, Robin, Duckworth, Frank, Champkin, Julian, Sweetland, Mary, Church, Jenny, Murray, Liam, Grossmann, Heiko, Chandler, Richard, Barnett, Vic, Stander, Julian, Walters, Stephen, Harris, Liz, Henderson, G. Robin, Samworth, Richard, Fielding, Antony, Mugglestone, Moira, Lannon, Jenny, Martin, David, Merchant, Maurice, Kounali, Daphne, Brignell, Chris, Spowage, Mairi, Torsney, Ben, Mayer, Claus Dieter, Su, Ting-Li, Baxter, Paul, Logsdon, John, Hildreth, Tony, Hopewell, Jemma, Baksh, Fazil, Hilditch, Sara, Smith, Paul, Eales, John, Turner, Heather, Grimes, Tom, Hand, David, and Vincent, Sayer

Published
2010

23. Precursors and correlates of transient and persistent longitudinal profiles of psychotic experiences from late childhood through early adulthood

Author

Rammos, Alexandros, primary, Sullivan, Sarah A., additional, Kounali, Daphne, additional, Jones, Hannah J., additional, Hammerton, Gemma, additional, Hines, Lindsey A., additional, Lewis, Glyn, additional, Jones, Peter B., additional, Cannon, Mary, additional, Thompson, Andrew, additional, Wolke, Dieter, additional, Heron, Jon, additional, and Zammit, Stanley, additional

Published
2021
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26. How much change is enough? Evidence from a longitudinal study on depression in UK primary care.

Author

Kounali, Daphne, Button, Katherine S., Lewis, Gemma, Gilbody, Simon, Kessler, David, Araya, Ricardo, Duffy, Larisa, Lanham, Paul, Peters, Tim J., Wiles, Nicola, and Lewis, Glyn

Subjects
*CONFIDENCE intervals, *INTERVIEWING, *PRIMARY health care, *PSYCHOLOGICAL tests, *MENTAL depression, *QUESTIONNAIRES, *DESCRIPTIVE statistics, *ANXIETY, *LONGITUDINAL method
Abstract

Background: The Patient Health Questionnaire (PHQ-9), the Beck Depression Inventory (BDI-II) and the Generalised Anxiety Disorder Assessment (GAD-7) are widely used in the evaluation of interventions for depression and anxiety. The smallest reduction in depressive symptoms that matter to patients is known as the Minimum Clinically Important Difference (MCID). Little empirical study of the MCID for these scales exists. Methods: A prospective cohort of 400 patients in UK primary care were interviewed on four occasions, 2 weeks apart. At each time point, participants completed all three questionnaires and a 'global rating of change' scale (GRS). MCID estimation relied on estimated changes in symptoms according to reported improvement on the GRS scale, stratified by baseline severity on the Clinical Interview Schedule (CIS-R). Results: For moderate baseline severity, those who reported improvement on the GRS had a reduction of 21% (95% confidence interval (CI) −26.7 to −14.9) on the PHQ-9; 23% (95% CI −27.8 to −18.0) on the BDI-II and 26.8% (95% CI −33.5 to −20.1) on the GAD-7. The corresponding threshold scores below which participants were more likely to report improvement were −1.7, −3.5 and −1.5 points on the PHQ-9, BDI-II and GAD-7, respectively. Patients with milder symptoms require much larger reductions as percentage of their baseline to endorse improvement. Conclusions: An MCID representing 20% reduction of scores in these scales, is a useful guide for patients with moderately severe symptoms. If treatment had the same effect on patients irrespective of baseline severity, those with low symptoms are unlikely to notice a benefit. Funding: Funding. National Institute for Health Research. [ABSTRACT FROM AUTHOR]

Published
2022
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27. Precursors and correlates of transient and persistent longitudinal profiles of psychotic experiences from late childhood through early adulthood.

Author

Rammos, Alexandros, Sullivan, Sarah A., Kounali, Daphne, Jones, Hannah J., Hammerton, Gemma, Hines, Lindsey A., Lewis, Glyn, Jones, Peter B., Cannon, Mary, Thompson, Andrew, Wolke, Dieter, Heron, Jon, and Zammit, Stanley

Abstract

Background: Psychotic experiences are reported by 5-10% of young people, although only a minority persist and develop into psychotic disorders. It is unclear what characteristics differentiate those with transient psychotic experiences from those with persistent psychotic experiences that are more likely to be of clinical relevance.Aims: To investigate how longitudinal profiles of psychotic experiences, created from assessments at three different time points, are influenced by early life and co-occurring factors.Method: Using data from 8045 individuals from a birth cohort study, longitudinal profiles of psychotic experiences based on semi-structured interviews conducted at 12, 18 and 24 years were defined. Environmental, cognitive, psychopathological and genetic determinants of these profiles were investigated, along with concurrent changes in psychopathology and cognition.Results: Following multiple imputations, the distribution of longitudinal profiles of psychotic experiences was none (65.7%), transient (24.1%), low-frequency persistent (8.4%) and high-frequency persistent (1.7%). Individuals with high-frequency persistent psychotic experiences were more likely to report traumatic experiences, other psychopathology, a more externalised locus of control, reduced emotional stability and conscientious personality traits in childhood, compared with those with transient psychotic experiences. These characteristics also differed between those who had any psychotic experiences and those who did not.Conclusions: These findings indicate that the same risk factors are associated with incidence as with persistence of psychotic experiences. Thus, it might be that the severity of exposure, rather than the presence of specific disease-modifying factors, is most likely to determine whether psychotic experiences are transient or persist, and potentially develop into a clinical disorder over time. [ABSTRACT FROM AUTHOR]

Published
2022
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28. Trajectories of child emotional and behavioural difficulties before and during the COVID-19 pandemic in a longitudinal UK cohort

Author

Paul, Elise, primary, Kounali, Daphne, additional, Kwong, Alex S. F., additional, Smith, Daniel, additional, Costantini, Ilaria, additional, Lawlor, Deborah A., additional, Sayal, Kapil, additional, Bould, Helen, additional, Timpson, Nicholas J., additional, Northstone, Kate, additional, Lewcock, Melanie, additional, Tilling, Kate, additional, and Pearson, Rebecca M., additional

Published
2021
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31. The clinical effectiveness of sertraline in primary care and the role of depression severity and duration : a pragmatic, double-blind, placebo-controlled randomised trial

Author

Lewis, Gemma, Duffy, Larisa, Ades, Anthony E, Amos, Rebekah, Araya, Ricardo, Brabyn, Sally Elizabeth, Button, Katherine S, Churchill, Rachel Christine, Derrick, Catherine, Dowrick, Christopher, Gilbody, Simon, Fawsitt, Christopher, Hollingworth, William, Jones, Vivien, Kendrick, Tony, Kessler, David, Kounali, Daphne, Khan, Naila, Lanham, Paul, Pervin, Jodi, Peters, Tim J., Riozzie, Derek, Salaminios, George, Thomas, Laura, Welton, Nicky J., Wiles, Nicola, Woodhouse, Rebecca, and Lewis, Glyn

Published
2019

33. S134. INCIDENCE, IMPACT AND TRAJECTORIES OF PSYCHOTIC EXPERIENCES FROM CHILDHOOD TO ADULTHOOD, AND PREDICTION OF PSYCHOTIC DISORDER

Author

Zammit, Stanley, primary, Heron, Jon, primary, Rammos, Alexandros, primary, Jones, Hannah, primary, Kounali, Daphne, primary, Sullivan, Sarah, primary, Croft, Jazz, primary, Cannon, Mary, primary, David, Anthony, primary, Fletcher, Paul, primary, Holmans, Peter, primary, Jones, Peter, primary, Linden, David, primary, Lewis, Glyn, primary, Owen, Michael, primary, O’Donovan, Michael, primary, Thompson, Andrew, primary, and Wolke, Dieter, primary

Published
2020
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35. A Population-Based Cohort Study Examining the Incidence and Impact of Psychotic Experiences From Childhood to Adulthood, and Prediction of Psychotic Disorder

Author

Sullivan, Sarah A., primary, Kounali, Daphne, additional, Cannon, Mary, additional, David, Anthony S., additional, Fletcher, Paul C., additional, Holmans, Peter, additional, Jones, Hannah, additional, Jones, Peter B., additional, Linden, David E.J., additional, Lewis, Glyn, additional, Owen, Michael J., additional, O’Donovan, Michael, additional, Rammos, Alexandros, additional, Thompson, Andrew, additional, Wolke, Dieter, additional, Heron, Jon, additional, and Zammit, Stanley, additional

Published
2020
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37. Trajectories of Child Emotional and Behavioural Difficulties Before and During the COVID-19 Pandemic in a Longitudinal UK Cohort

Author

Paul, Elise, primary, Kounali, Daphne, additional, Kwong, Alex SF, additional, Smith, Daniel, additional, Costantini, Ilaria, additional, Lawlor, Debbie, additional, Sayal, Kapil, additional, Bould, Helen, additional, Timpson, Nicholas J., additional, Northstone, Kate, additional, Lewcock, Melanie, additional, Tilling, Kate, additional, and Pearson, Rebecca M., additional

Published
2020
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38. Antidepressant treatment with sertraline for adults with depressive symptoms in primary care: the PANDA research programme including RCT

Author

Duffy, Larisa, primary, Lewis, Gemma, additional, Ades, Anthony, additional, Araya, Ricardo, additional, Bone, Jessica, additional, Brabyn, Sally, additional, Button, Katherine, additional, Churchill, Rachel, additional, Croudace, Tim, additional, Derrick, Catherine, additional, Dixon, Padraig, additional, Dowrick, Christopher, additional, Fawsitt, Christopher, additional, Fusco, Louise, additional, Gilbody, Simon, additional, Harmer, Catherine, additional, Hobbs, Catherine, additional, Hollingworth, William, additional, Jones, Vivien, additional, Kendrick, Tony, additional, Kessler, David, additional, Khan, Naila, additional, Kounali, Daphne, additional, Lanham, Paul, additional, Malpass, Alice, additional, Munafo, Marcus, additional, Pervin, Jodi, additional, Peters, Tim, additional, Riozzie, Derek, additional, Robinson, Jude, additional, Salaminios, George, additional, Sharp, Debbie, additional, Thom, Howard, additional, Thomas, Laura, additional, Welton, Nicky, additional, Wiles, Nicola, additional, Woodhouse, Rebecca, additional, and Lewis, Glyn, additional

Published
2019
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39. Comparison between self-administered depression questionnaires and patients' own views of changes in their mood: a prospective cohort study in primary care.

Author

Hobbs, Catherine, Lewis, Gemma, Dowrick, Christopher, Kounali, Daphne, Peters, Tim J., and Lewis, Glyn

Subjects
AFFECT (Psychology), CONFIDENCE intervals, HEALTH outcome assessment, PATIENTS' attitudes, ATTITUDES toward illness, COMPARATIVE studies, PRIMARY health care, QUALITATIVE research, PSYCHOLOGICAL tests, MENTAL depression, QUESTIONNAIRES, DESCRIPTIVE statistics, ANXIETY, LONGITUDINAL method
Abstract

Background: Self-administered questionnaires are widely used in primary care and other clinical settings to assess the severity of depressive symptoms and monitor treatment outcomes. Qualitative studies have found that changes in questionnaire scores might not fully capture patients' experience of changes in their mood but there are no quantitative studies of this issue. We examined the extent to which changes in scores from depression questionnaires disagreed with primary care patients' perceptions of changes in their mood and investigated factors influencing this relationship. Methods: Prospective cohort study assessing patients on four occasions, 2 weeks apart. Patients (N = 554) were recruited from primary care surgeries in three UK sites (Bristol, Liverpool and York) and had reported depressive symptoms or low mood in the past year [68% female, mean age 48.3 (s.d. 12.6)]. Main outcome measures were changes in scores on patient health questionnaire (PHQ-9) and beck depression inventory (BDI-II) and the patients' own ratings of change. Results: There was marked disagreement between clinically important changes in questionnaire scores and patient-rated change, with disagreement of 51% (95% CI 46–55%) on PHQ-9 and 55% (95% CI 51–60%) on BDI-II. Patients with more severe anxiety were less likely, and those with better mental and physical health-related quality of life were more likely, to report feeling better, having controlled for depression scores. Conclusions: Our results illustrate the limitations of self-reported depression scales to assess clinical change. Clinicians should be cautious in interpreting changes in questionnaire scores without further clinical assessment. [ABSTRACT FROM AUTHOR]

Published
2021
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42. Correction: Sera selected from national STI surveillance system shows Chlamydia trachomatis PgP3 antibody correlates with time since infection and number of previous infections

Author

Blomquist, Paula B., primary, Migchelsen, Stephanie J., additional, Wills, Gillian, additional, McClure, Eleanor, additional, Ades, Anthony E., additional, Kounali, Daphne, additional, Dunbar, J. Kevin, additional, McClure, Myra O., additional, Soldan, Kate, additional, Woodhall, Sarah C., additional, and Horner, Patrick, additional

Published
2019
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43. Proceedings of Patient Reported Outcome Measure’s (PROMs) Conference Oxford 2017: Advances in Patient Reported Outcomes Research

Author

Velikova, Galina, Valderas, Jose M., Potter, Caroline, Batchelder, Laurie, A’Court, Christine, Baker, Matthew, Bostock, Jennifer, Coulter, Angela, Fitzpatrick, Ray, Forder, Julien, Fox, Diane, Geneen, Louise, Gibbons, Elizabeth, Jenkinson, Crispin, Jones, Karen, Kelly, Laura, Peters, Michele, Mulhern, Brendan, Labeit, Alexander, Rowen, Donna, Meadows, Keith, Elliott, Jackie, Brazier, John E., Knowles, Emma, Keetharuth, Anju, Connell, Janice, Carlton, Jill, Buck, Lizzie Taylor, Ricketts, Thomas, Barkham, Michael, Goswami, Pushpendra, Salek, Sam, Ionova, Tatyana, Oliva, Esther, Fielding, Adele K., Karakantza, Marina, Al-Ismail, Saad, Collins, Graham P., McConnell, Stewart, Langton, Catherine, Jennings, Daniel M., Else, Roger, Kell, Jonathan, Ward, Helen, Day, Sophie, Lumley, Elizabeth, Phillips, Patrick, Duncan, Rosie, Buckley-Woods, Helen, Aber, Ahmed, Jones, Gerogina, Michaels, Jonathan, Porter, Ian, Gangannagaripalli, Jaheeda, Davey, Antoinette, Ricci-Cabello, Ignacio, Haywood, Kirstie, Hansen, Stine Thestrup, Valderas, Jose, Roberts, Deb, Gumber, Anil, Podmore, Bélène, Hutchings, Andrew, van der Meulen, Jan, Aggarwal, Ajay, Konan, Sujith, Price, Andrew, Jackson, William, Bottomley, Nick, Philiips, Michael, Knightley-Day, Toby, Beard, David, Greenhalgh, Joanne, Gooding, Kate, Valderas, Chema, Wright, Judy, Dalkin, Sonia, Meads, David, Black, Nick, Fawkes, Carol, Froud, Robert, Carnes, Dawn, Cook, Jonathan, Dakin, Helen, Smith, James, Kang, Sujin, Griffiths, Catrin, Guest, Ella, Harcourt, Diana, Murphy, Mairead, Hollinghurst, Sandra, Salisbury, Chris, Gao, Anqi, Lemanska, Agnieszka, Chen, Tao, Dearnaley, David P., Jena, Rajesh, Sydes, Matthew, Faithfull, Sara, Ades, A. E., Kounali, Daphne, Lu, Guobing, Rombach, Ines, Gray, Alastair, Rivero-Arias, Oliver, Holch, Patricia, Holmes, Marie, Rodgers, Zoe, Dickinson, Sarah, Clayton, Beverly, Davidson, Susan, Routledge, Jacqui, Glennon, Julia, Henry, Ann M., Franks, Kevin, Maguire, Roma, McCann, Lisa, Young, Teresa, Armes, Jo, Harris, Jenny, Miaskowski, Christine, Kotronoulas, Grigorios, Miller, Morven, Ream, Emma, Patiraki, Elizabeth, Geiger, Alexander, Berg, Geir V., Flowerday, Adrian, Donnan, Peter, McCrone, Paul, Apostolidis, Kathi, Fox, Patricia, Furlong, Eileen, Kearney, Nora, Gibbons, Chris, Fischer, Felix, Coste, Joel, Martinez, Jose Valderas, Rose, Matthias, Leplege, Alain, Shingler, Sarah, Aldhouse, Natalie, Al-Zubeidi, Tamara, Trigg, Andrew, Kitchen, Helen, Green, Colin, Coast, Joanna, Smith, Sarah, Hendriks, Jolijn, Shah, Koonal, Ramos-Goni, Juan-Manuel, Kreimeier, Simone, Herdman, Mike, Devlin, Nancy, Finch, Aureliano Paolo, Mukuria, Clara, Zamora, Bernarda, Parkin, David, Feng, Yan, Bateman, Andrew, Patton, Thomas, Gutacker, Nils, and Health Economics and Health Technology Assessment

Subjects
SDG 17 - Partnerships for the Goals, 1117 Public Health And Health Services, Health Policy & Services
Abstract

The proceedings contain 36 papers. The topics discussed include: using patient reported outcome measures (PROMs) in cancer care; validation of the long-term conditions questionnaire (LTCQ) in a diverse sample of health and social care users in England; the national institutes of health patient-reported outcomes measurement information system (PROMIS): a view from the UK; constructing and validating the short recovering quality of life (ReQoL) measure for use in a mental health population; developing preference based measures for diabetes for calculating QALYs: DHP-3D and DHP-5D; development of a novel patient reported outcome measure for patients with haematological malignancy: a qualitative study; and examining the relevance of PROMs to patients: a review of qualitative data capturing which HRQoL domains are important to patients.

Published
2017

44. Sera selected from national STI surveillance system shows Chlamydia trachomatis PgP3 antibody correlates with time since infection and number of previous infections

Author

Blomquist, Paula B., primary, Mighelsen, Stephanie J., additional, Wills, Gillian, additional, McClure, Eleanor, additional, Ades, Anthony E., additional, Kounali, Daphne, additional, Dunbar, J. Kevin, additional, McClure, Myra O., additional, Soldan, Kate, additional, Woodhall, Sarah C., additional, and Horner, Patrick, additional

Published
2018
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45. Heart disease risk-factor status and dietary changes in the Cretan population over the past 30 y: the Seven Countries Study

Author

Kafatos, Anthony, Diacatou, Anastasia, Voukiklaris, George, Nikolakakis, Nick, Vlachonikolis, John, Kounali, Daphne, Mamalakis, George, and Dontas, Anastasios S.

Subjects
Crete -- Demographic aspects, Diet -- Health aspects, Coronary heart disease -- Risk factors, Nutrition -- Evaluation, Food/cooking/nutrition, Health
Abstract

A follow-up study was conducted to identify the heart disease risk-factor status and dietary changes of surviving elderly subjects in Crete who took part in the Seven Countries Study in 1960. In 1991, data were obtained from 245 of the 686 original male participants (169 of the original 40-49-y age group and 76 men from the 50-59-y age group). In 1991, the men were 70-79 and 80-89 y old. There was a significant (11.5%) increase in serum total cholesterol concentrations between 1960 and 1991. Body mass index and systolic and diastolic blood pressures also increased significantly, and all age groups were characterized by central obesity. A representative subsample of 21 men took part in a 3-d weighed food record study. Dietary data indicated increases in the intake of saturated fat and decreases in monounsaturated fat over the 30-y period. Comparison with a 1962 representative Cretan sample indicated a significantly increased concentration of adipose palmitic acid (16:0) in our surviving sample. The observed changes occurred during a period when many developed countries were observing a decline in most heart disease risk factors.

Published
1997

46. Proceedings of Patient Reported Outcome Measure’s (PROMs) Conference Oxford 2017: Advances in Patient Reported Outcomes Research : Oxford, UK. 8th June 2017

Author

Velikova, Galina Valderas, Jose M. Potter, Caroline Batchelder, Laurie A’Court, Christine Baker, Matthew Bostock, Jennifer Coulter, Angela Fitzpatrick, Ray Forder, Julien Fox, Diane Geneen, Louise Gibbons, Elizabeth Jenkinson, Crispin Jones, Karen Kelly, Laura Peters, Michele Mulhern, Brendan Labeit, Alexander Rowen, Donna Meadows, Keith Elliott, Jackie Brazier, John Knowles, Emma Keetharuth, Anju Brazier, John Connell, Janice Carlton, Jill Buck, Lizzie Taylor Ricketts, Thomas Barkham, Michael Goswami, Pushpendra Salek, Sam Ionova, Tatyana Oliva, Esther Fielding, Adele K. Karakantza, Marina Al-Ismail, Saad Collins, Graham P. McConnell, Stewart Langton, Catherine Jennings, Daniel M. Else, Roger Kell, Jonathan Ward, Helen Day, Sophie Lumley, Elizabeth Phillips, Patrick Duncan, Rosie Buckley-Woods, Helen Aber, Ahmed Jones, Gerogina Michaels, Jonathan Porter, Ian Gangannagaripalli, Jaheeda Davey, Antoinette Ricci-Cabello, Ignacio Haywood, Kirstie Hansen, Stine Thestrup Valderas, Jose Roberts, Deb Gumber, Anil Podmore, Bélène Hutchings, Andrew van der Meulen, Jan Aggarwal, Ajay Konan, Sujith Price, Andrew Jackson, William Bottomley, Nick Philiips, Michael Knightley-Day, Toby Beard, David Gibbons, Elizabeth Fitzpatrick, Ray Greenhalgh, Joanne Gooding, Kate Gibbons, Elizabeth Valderas, Chema Wright, Judy Dalkin, Sonia Meads, David Black, Nick Fawkes, Carol Froud, Robert Carnes, Dawn Price, Andrew Cook, Jonathan Dakin, Helen Smith, James Kang, Sujin Beard, David Griffiths, Catrin Guest, Ella Harcourt, Diana Murphy, Mairead Hollinghurst, Sandra Salisbury, Chris Carlton, Jill Elliott, Jackie Rowen, Donna Gao, Anqi Price, Andrew Beard, David Lemanska, Agnieszka Chen, Tao Dearnaley, David P. Jena, Rajesh Sydes, Matthew Faithfull, Sara Ades, A. E. Kounali, Daphne Lu, Guobing Rombach, Ines Gray, Alastair Jenkinson, Crispin Rivero-Arias, Oliver Holch, Patricia Holmes, Marie Rodgers, Zoe Dickinson, Sarah Clayton, Beverly Davidson, Susan Routledge, Jacqui Glennon, Julia Henry, Ann M. Franks, Kevin Velikova, Galina Maguire, Roma McCann, Lisa Young, Teresa Armes, Jo Harris, Jenny Miaskowski, Christine Kotronoulas, Grigorios Miller, Morven Ream, Emma Patiraki, Elizabeth Geiger, Alexander Berg, Geir V. Flowerday, Adrian Donnan, Peter McCrone, Paul Apostolidis, Kathi Fox, Patricia Furlong, Eileen Kearney, Nora Gibbons, Chris Fischer, Felix Gibbons, Chris Coste, Joel Martinez, Jose Valderas Rose, Matthias Leplege, Alain Shingler, Sarah Aldhouse, Natalie Al-Zubeidi, Tamara Trigg, Andrew Kitchen, Helen Davey, Antoinette Porter, Ian Green, Colin Valderas, Jose M. Coast, Joanna Smith, Sarah Hendriks, Jolijn Black, Nick Shah, Koonal Rivero-Arias, Oliver Ramos-Goni, Juan-Manuel Kreimeier, Simone Herdman, Mike Devlin, Nancy Finch, Aureliano Paolo Brazier, John E. Mukuria, Clara Zamora, Bernarda Parkin, David Feng, Yan Bateman, Andrew Herdman, Mike Devlin, Nancy Patton, Thomas Gutacker, Nils Shah, Koonal

Published
2017

47. Additional file 1: of A randomised controlled trial assessing the severity and duration of depressive symptoms associated with a clinically significant response to sertraline versus placebo, in people presenting to primary care with depression (PANDA trial): study protocol for a randomised controlled trial

Author

Salaminios, George, Duffy, Larisa, Ades, Anthony, Araya, Ricardo, Button, Katherine, Churchill, Rachel, Croudace, Tim, Derrick, Catherine, Padraig Dixon, Dowrick, Christopher, Gilbody, Simon, Hollingworth, William, Jones, Vivien, Kendrick, Tony, Kessler, David, Kounali, Daphne, Lanham, Paul, Malpass, Alice, Peters, Tim, Riozzie, Derek, Robinson, Jude, Sharp, Debbie, Thomas, Laura, Welton, Nicky, Wiles, Nicola, and Lewis, Glyn

Abstract

SPIRIT 2013 Checklist: recommended items to address in a clinical trial protocol and related documents. (DOC 122 kb)

Published
2017
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49. A randomised controlled trial assessing the severity and duration of depressive symptoms associated with a clinically significant response to sertraline versus placebo, in people presenting to primary care with depression (PANDA trial): study protocol for a randomised controlled trial

Author

Salaminios, George, primary, Duffy, Larisa, additional, Ades, Anthony, additional, Araya, Ricardo, additional, Button, Katherine S., additional, Churchill, Rachel, additional, Croudace, Tim, additional, Derrick, Catherine, additional, Dixon, Padraig, additional, Dowrick, Christopher, additional, Gilbody, Simon, additional, Hollingworth, William, additional, Jones, Vivien, additional, Kendrick, Tony, additional, Kessler, David, additional, Kounali, Daphne, additional, Lanham, Paul, additional, Malpass, Alice, additional, Peters, Tim J., additional, Riozzie, Derek, additional, Robinson, Jude, additional, Sharp, Debbie, additional, Thomas, Laura, additional, Welton, Nicky J., additional, Wiles, Nicola, additional, and Lewis, Glyn, additional

Published
2017
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50. Chlamydia trachomatis Pgp3 antibody persists and correlates with self-reported infection and behavioural risks in a blinded cohort study

Author

Horner, Patrick J., Wills, Gillian S., Righarts, Antoinette, Vieira, Sueli, Kounali, Daphne, Samuel, Dhanraj, Winston, Alan, Muir, David, Dickson, Nigel P., and McClure, Myra O.

Subjects
Adult, Male, Physiology, General Science & Technology, Sexual Behavior, Immunology, Oceania, Sexually Transmitted Diseases, lcsh:Medicine, Chlamydia trachomatis, Enzyme-Linked Immunosorbent Assay, Opportunistic Infections, Research and Analysis Methods, Pathology and Laboratory Medicine, Biochemistry, Pediatrics, Sensitivity and Specificity, Antibodies, Geographical locations, Chlamydia Infection, Cohort Studies, Bacterial Proteins, Risk Factors, Immune Physiology, MD Multidisciplinary, Medicine and Health Sciences, Humans, Enzyme-Linked Immunoassays, Immunoassays, lcsh:Science, Antigens, Bacterial, Immune System Proteins, lcsh:R, Biology and Life Sciences, Proteins, Chlamydia Infections, Antibodies, Bacterial, Serology, Infectious Diseases, ROC Curve, Research Design, Area Under Curve, Immunologic Techniques, Female, lcsh:Q, Self Report, People and places, Research Article, New Zealand
Abstract

Chlamydia trachomatis (Ct) serological studies in populations could help monitor changes in lifetime cumulative risk of infection. We developed a double-antigen sandwich ELISA based on the Ct-specific Pgp3 antigen, then tested blind stored sera from over 800 participants in a New Zealand birth cohort from Dunedin at ages 26, 32 and 38. The double-antigen sandwich ELISA was more sensitive than our previously characterised indirect Pgp3 ELISA. Pgp3 antibody was detected more often in women compared to men and correlated with increasing numbers of sexual partners, self-reported Ct, and younger age at sexual debut in both women and men. At age 26, 24.1% (99/411) of women were Pgp3 seropositive, as were 79.5% (35/44) of those reporting Ct infection; Pgp3 antibody persisted to age 38 in 96.5% (83/86). In men at age 26, the figures were 10.7% (47/442) and 25.0% (6/24), respectively, with high (83.9%) antibody persistence to age 38. At age 38, among those Pgp3 seropositive, 63.3% of women and 83.1% of men had not reported Ct infection. Thus, Ct-specific Pgp3 antibody was detected in most women reporting Ct infection and correlated with risk of infection in those who did not, with most infections remaining undetected. As this antibody persisted for at least twelve years in 96% of these women, serology could be used to evaluate Ct prevention programmes among women.

Published
2016

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