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1. Longevity biotechnology:bridging AI, biomarkers, geroscience and clinical applications for healthy longevity

Author

Lyu, Yu Xuan, Fu, Qiang, Wilczok, Dominika, Ying, Kejun, King, Aaron, Antebi, Adam, Vojta, Aleksandar, Stolzing, Alexandra, Moskalev, Alexey, Georgievskaya, Anastasia, Maier, Andrea B., Olsen, Andrea, Groth, Anja, Simon, Anna Katharina, Brunet, Anne, Jamil, Aisyah, Kulaga, Anton, Bhatti, Asif, Yaden, Benjamin, Pedersen, Bente Klarlund, Schumacher, Björn, Djordjevic, Boris, Kennedy, Brian, Chen, Chieh, Huang, Christine Yuan, Correll, Christoph U., Murphy, Coleen T., Ewald, Collin Y., Chen, Danica, Valenzano, Dario Riccardo, Sołdacki, Dariusz, Erritzoe, David, Meyer, David, Sinclair, David A., Chini, Eduardo Nunes, Teeling, Emma C., Morgen, Eric, Verdin, Eric, Vernet, Erik, Pinilla, Estefano, Fang, Evandro F., Bischof, Evelyne, Mercken, Evi M., Finger, Fabian, Kuipers, Folkert, Pun, Frank W., Gyülveszi, Gabor, Civiletto, Gabriele, Zmudze, Garri, Blander, Gil, Pincus, Harold A., McClure, Joshua, Kirkland, James L., Peyer, James, Justice, Jamie N., Vijg, Jan, Gruhn, Jennifer R., McLaughlin, Jerry, Mannick, Joan, Passos, João, Baur, Joseph A., Betts-LaCroix, Joe, Sedivy, John M., Speakman, John R., Shlain, Jordan, von Maltzahn, Julia, Andreasson, Katrin I., Moody, Kelsey, Palikaras, Konstantinos, Fortney, Kristen, Niedernhofer, Laura J., Rasmussen, Lene Juel, Veenhoff, Liesbeth M., Melton, Lisa, Ferrucci, Luigi, Quarta, Marco, Koval, Maria, Marinova, Maria, Hamalainen, Mark, Unfried, Maximilian, Ringel, Michael S., Filipovic, Milos, Topors, Mourad, Mitin, Natalia, Roy, Nawal, Pintar, Nika, Barzilai, Nir, Binetti, Paolo, Singh, Parminder, Kohlhaas, Paul, Robbins, Paul D., Rubin, Paul, Fedichev, Peter O., Kamya, Petrina, Muñoz-Canoves, Pura, Cabo, Rafael de, Faragher, Richard G.A., Konrad, Rob, Ripa, Roberto, Mansukhani, Robin, Büttner, Sabrina, Wickström, Sara A., Brunemeier, Sebastian, Jakimov, Sergey, Luo, Shan, Rosenzweig-Lipson, Sharon, Tsai, Shih Yin, Dimmeler, Stefanie, Rando, Thomas A., Peterson, Tim R., Woods, Tina, Wyss-Coray, Tony, Finkel, Toren, Strauss, Tzipora, Gladyshev, Vadim N., Longo, Valter D., Dwaraka, Varun B., Gorbunova, Vera, Acosta-Rodríguez, Victoria A., Sorrentino, Vincenzo, Sebastiano, Vittorio, Li, Wenbin, Suh, Yousin, Zhavoronkov, Alex, Scheibye-Knudsen, Morten, Bakula, Daniela, Lyu, Yu Xuan, Fu, Qiang, Wilczok, Dominika, Ying, Kejun, King, Aaron, Antebi, Adam, Vojta, Aleksandar, Stolzing, Alexandra, Moskalev, Alexey, Georgievskaya, Anastasia, Maier, Andrea B., Olsen, Andrea, Groth, Anja, Simon, Anna Katharina, Brunet, Anne, Jamil, Aisyah, Kulaga, Anton, Bhatti, Asif, Yaden, Benjamin, Pedersen, Bente Klarlund, Schumacher, Björn, Djordjevic, Boris, Kennedy, Brian, Chen, Chieh, Huang, Christine Yuan, Correll, Christoph U., Murphy, Coleen T., Ewald, Collin Y., Chen, Danica, Valenzano, Dario Riccardo, Sołdacki, Dariusz, Erritzoe, David, Meyer, David, Sinclair, David A., Chini, Eduardo Nunes, Teeling, Emma C., Morgen, Eric, Verdin, Eric, Vernet, Erik, Pinilla, Estefano, Fang, Evandro F., Bischof, Evelyne, Mercken, Evi M., Finger, Fabian, Kuipers, Folkert, Pun, Frank W., Gyülveszi, Gabor, Civiletto, Gabriele, Zmudze, Garri, Blander, Gil, Pincus, Harold A., McClure, Joshua, Kirkland, James L., Peyer, James, Justice, Jamie N., Vijg, Jan, Gruhn, Jennifer R., McLaughlin, Jerry, Mannick, Joan, Passos, João, Baur, Joseph A., Betts-LaCroix, Joe, Sedivy, John M., Speakman, John R., Shlain, Jordan, von Maltzahn, Julia, Andreasson, Katrin I., Moody, Kelsey, Palikaras, Konstantinos, Fortney, Kristen, Niedernhofer, Laura J., Rasmussen, Lene Juel, Veenhoff, Liesbeth M., Melton, Lisa, Ferrucci, Luigi, Quarta, Marco, Koval, Maria, Marinova, Maria, Hamalainen, Mark, Unfried, Maximilian, Ringel, Michael S., Filipovic, Milos, Topors, Mourad, Mitin, Natalia, Roy, Nawal, Pintar, Nika, Barzilai, Nir, Binetti, Paolo, Singh, Parminder, Kohlhaas, Paul, Robbins, Paul D., Rubin, Paul, Fedichev, Peter O., Kamya, Petrina, Muñoz-Canoves, Pura, Cabo, Rafael de, Faragher, Richard G.A., Konrad, Rob, Ripa, Roberto, Mansukhani, Robin, Büttner, Sabrina, Wickström, Sara A., Brunemeier, Sebastian, Jakimov, Sergey, Luo, Shan, Rosenzweig-Lipson, Sharon, Tsai, Shih Yin, Dimmeler, Stefanie, Rando, Thomas A., Peterson, Tim R., Woods, Tina, Wyss-Coray, Tony, Finkel, Toren, Strauss, Tzipora, Gladyshev, Vadim N., Longo, Valter D., Dwaraka, Varun B., Gorbunova, Vera, Acosta-Rodríguez, Victoria A., Sorrentino, Vincenzo, Sebastiano, Vittorio, Li, Wenbin, Suh, Yousin, Zhavoronkov, Alex, Scheibye-Knudsen, Morten, and Bakula, Daniela

Abstract

The recent unprecedented progress in ageing research and drug discovery brings together fundamental research and clinical applications to advance the goal of promoting healthy longevity in the human population. We, from the gathering at the Aging Research and Drug Discovery Meeting in 2023, summarised the latest developments in healthspan biotechnology, with a particular emphasis on artificial intelligence (AI), biomarkers and clocks, geroscience, and clinical trials and interventions for healthy longevity. Moreover, we provide an overview of academic research and the biotech industry focused on targeting ageing as the root of age-related diseases to combat multimorbidity and extend healthspan. We propose that the integration of generative AI, cutting-edge biological technology, and longevity medicine is essential for extending the productive and healthy human lifespan.

Published
2024

4. Vilka kompetenser behövs hos nyutexaminerade studenter? : En kvantitativ studie om revisionsbyråers och lärosätens förväntningar på kompetens

Author

Alfredsson, Amanda and Koval, Maria

Subjects
Lärosäten, Expectation gap, Competence requirements, Higher education institutions, Kompetenskrav, Förväntningsgap, Kompetenser, Competencies, Audit firms, Revisionsbyråer, Business Administration, Företagsekonomi
Abstract

This study examines which competencies, among recent graduates in accounting and auditing, audit firms versus higher education institutions consider to be important and whether there are significant differences of opinion between these two groups. The study is limited to higher education institutions that train and teach in accounting and/or auditing as well as staff at auditing firms that practice and practice in accounting and/or auditing. We used T-tests and ANOVA tests to carry out the analysis of the collected answers. The results confirm previous studies to some extent, around the fact that there is an expectation gap between practitioners and educators, as some of the competencies examined had significant differences. We found that the intellectual skills; analytical ability, problem solving and critical thinking were the most important competencies for both groups. In addition, higher education institutions valued analytical skills as the most important competence, while audit firms valued accountability as the most important. Denna studie undersöker vilka kompetenser, hos nyutexaminerade inom redovisning och revision, revisionsbyråer kontra lärosäten anser vara av vikt och om det finns signifikanta skillnader i åsikter mellan dessa två grupper. Studien är begränsad till lärosäten som utbildar och undervisar inom redovisning- och/eller revision samt personal på revisionsbyråer som är verksamma inom redovisning- och/eller revision. För att genomföra analysen användes T-test samt ANOVA-test för att genomföra analysen på de insamlade svaren. Resultaten bekräftar till viss del tidigare studier, kring att det finns ett förväntningsgap mellan utövare och utbildare, då några av de undersökta kompetenserna hade signifikanta skillnader. Kompetensområdet för de intellektuella färdigheterna; analytiska färdigheter, problemlösning samt kritiskt tänkande var de viktigaste kompetenserna för båda grupperna. Utöver detta värderade lärosätena analytiska färdigheter som den viktigaste kompetensen medan revisionsbyråerna värderade ansvarstagande som den viktigaste.

Published
2021

6. The Influence of Chronic Hyperhomocysteinemia on Connective Tissue Disorders in Case of Lipopolysaccharide-Induced Periodontitis.

Author

Khudan, Roman, Kyryliv, Mariia, Bekus, Iryna, Demyd, Anna, Koval, Maria, and Luchynskyi, Vitaliy

Subjects
PERIODONTITIS, CONNECTIVE tissues, HYPERHOMOCYSTEINEMIA, ELLAGIC acid, TISSUE metabolism, TOOTH loss, FUCOSE
Abstract

The progression of destructive phenomena in periodontal tissues depends on many factors, including many systemic pathologies that act as comorbidities and contribute to destruction of the periodontium that leads toward tooth loss. One of such comorbidities may be chronic hyperhomocysteinemia (HHcy). This study aimed to determine the features of connective tissue metabolism in rats with lipopolysaccharide (LPS)-induced periodontitis combined with chronic thiolactone HHcy. 48 white non-linear mature rats were divided into 4 groups: control; animals with a model of LPS-induced periodontitis; rats with chronic thiolactone HHcy; animals with a model of periodontitis combined with HHcy. The rats were sacrificed the day after the last LPS injection or the day after the last homocysteine thiolactone administration. Connective tissue metabolism was determined by the collagenolytic activity, the content of glycosaminoglycans (GAGs), fucose, unbound with proteins, and free hydroxyproline in blood serum. It was found that chronic thiolactone HHcy enhances the destruction of connective tissue in case of periodontitis, which is confirmed by the significant excess of collagenolytic activity (by 2.5 times; p=0.009) and the content of GAGs (by 61.7%; p=0.007) in the blood serum of animals with combined pathology in relation to animals with LPS-induced inflammation without concomitant pathology. [ABSTRACT FROM AUTHOR]

Published
2022

8. Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity.

Author

Lyu YX, Fu Q, Wilczok D, Ying K, King A, Antebi A, Vojta A, Stolzing A, Moskalev A, Georgievskaya A, Maier AB, Olsen A, Groth A, Simon AK, Brunet A, Jamil A, Kulaga A, Bhatti A, Yaden B, Pedersen BK, Schumacher B, Djordjevic B, Kennedy B, Chen C, Huang CY, Correll CU, Murphy CT, Ewald CY, Chen D, Valenzano DR, Sołdacki D, Erritzoe D, Meyer D, Sinclair DA, Chini EN, Teeling EC, Morgen E, Verdin E, Vernet E, Pinilla E, Fang EF, Bischof E, Mercken EM, Finger F, Kuipers F, Pun FW, Gyülveszi G, Civiletto G, Zmudze G, Blander G, Pincus HA, McClure J, Kirkland JL, Peyer J, Justice JN, Vijg J, Gruhn JR, McLaughlin J, Mannick J, Passos J, Baur JA, Betts-LaCroix J, Sedivy JM, Speakman JR, Shlain J, von Maltzahn J, Andreasson KI, Moody K, Palikaras K, Fortney K, Niedernhofer LJ, Rasmussen LJ, Veenhoff LM, Melton L, Ferrucci L, Quarta M, Koval M, Marinova M, Hamalainen M, Unfried M, Ringel MS, Filipovic M, Topors M, Mitin N, Roy N, Pintar N, Barzilai N, Binetti P, Singh P, Kohlhaas P, Robbins PD, Rubin P, Fedichev PO, Kamya P, Muñoz-Canoves P, de Cabo R, Faragher RGA, Konrad R, Ripa R, Mansukhani R, Büttner S, Wickström SA, Brunemeier S, Jakimov S, Luo S, Rosenzweig-Lipson S, Tsai SY, Dimmeler S, Rando TA, Peterson TR, Woods T, Wyss-Coray T, Finkel T, Strauss T, Gladyshev VN, Longo VD, Dwaraka VB, Gorbunova V, Acosta-Rodríguez VA, Sorrentino V, Sebastiano V, Li W, Suh Y, Zhavoronkov A, Scheibye-Knudsen M, and Bakula D

Subjects
Humans, Aging physiology, Geroscience methods, Artificial Intelligence, Biomarkers metabolism, Biotechnology methods, Longevity physiology
Abstract

The recent unprecedented progress in ageing research and drug discovery brings together fundamental research and clinical applications to advance the goal of promoting healthy longevity in the human population. We, from the gathering at the Aging Research and Drug Discovery Meeting in 2023, summarised the latest developments in healthspan biotechnology, with a particular emphasis on artificial intelligence (AI), biomarkers and clocks, geroscience, and clinical trials and interventions for healthy longevity. Moreover, we provide an overview of academic research and the biotech industry focused on targeting ageing as the root of age-related diseases to combat multimorbidity and extend healthspan. We propose that the integration of generative AI, cutting-edge biological technology, and longevity medicine is essential for extending the productive and healthy human lifespan.

Published
2024
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