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1. List of Contributors

Author

Agrawal, Pankaj B., primary, Akhtar, Yasmin, additional, Alallah, Jubara, additional, Alhassen, Ziad, additional, Altit, Gabriel, additional, AlZubaidi, Abbas, additional, Amlani, Lahin M., additional, Antelo, Martin, additional, Athalye-Jape, Gayatri, additional, Badarch, Jargalsaikhan, additional, Baer, Gerri, additional, Bagga, Nitasha, additional, Bahr, Timothy M., additional, Bar-Cohen, Yaniv, additional, M. Barr, Stephanie, additional, Bauer, Andrew J., additional, Bearer, Cynthia F., additional, Beckman, Ross M., additional, Beltempo, Marc, additional, Bembea, Melania M., additional, Berlin, Sheila, additional, Berry, Shandeigh N., additional, Bhandari, Vineet, additional, Bhatia, Shaifali, additional, Bhombal, Shazia, additional, Bigelow, Elaine O., additional, Blevins, Carley, additional, Boppana, Suresh, additional, Boss, Renee, additional, Brooks, Sandra, additional, Buonocore, Giuseppe, additional, Burnsed, Jennifer, additional, Calabria, Andrew C., additional, Carrasco, Melisa, additional, Carter, Brian S., additional, Chandrasekharan, Praveen, additional, Chavez-Valdez, Raul, additional, Choleva, Lauryn, additional, Christensen, Robert D., additional, Chung, Wendy K., additional, Coggins, Sarah A., additional, Cooke, David W., additional, Cummings, Laura, additional, Currie, Erin R., additional, Davidson, Joanne O., additional, Davis, Jonathan M., additional, Day-Richardson, Colby L., additional, De Leon, Diva D., additional, Dedhia, Kavita, additional, Dendi, Alvaro, additional, Deshpande, Anita, additional, Dionne, Janis M., additional, Donda, Keyur, additional, Donohue, Lee, additional, Doyle, Jefferson J., additional, Dulkerian, Susan J., additional, Dumpa, Vikramaditya, additional, Duncan, Andrea F., additional, Dunham, Alexandra M., additional, Ecret, DiAnn, additional, Ellis, Kelstan, additional, El-Metwally, Dina, additional, Etchill, Eric W., additional, Ethawi, Yahya, additional, Everett, Allen D., additional, Fabres, Jorge, additional, Felling, Ryan J., additional, Fenton, Tanis R., additional, Flannery, Dustin D., additional, Flynn, Joseph T., additional, Fredenburg, Michaelene, additional, Fuqua, John, additional, Garcia, Alejandro V., additional, Garzon, Steven, additional, Gauda, Estelle B., additional, Thompson, Marisa Gilstrop, additional, Goldenberg, Barton, additional, Salazar, Andres J. Gonzalez, additional, Goodwin, Julie E., additional, Goudy, Steven L., additional, Graham, Ernest, additional, Grauerholz, Kathryn, additional, Groves, Mari L., additional, Guillot, Mireille, additional, Gunn, Alistair J., additional, Gupta, Arjun, additional, Hackam, David J., additional, Hidalgo, Joaquin, additional, Honcharuk, Erin, additional, Htun, Zeyar, additional, Hudak, Mark L., additional, Driscoll, Colleen A. Hughes, additional, Huisman, Thierry A.G.M., additional, Jabroun, Mireille, additional, Jackson, Eric M., additional, Jain, Naveen, additional, Jain, Rajesh, additional, Jelin, Angie, additional, Jelin, Eric, additional, Juul, Sandra E., additional, Kaufman, David A., additional, BMBS, Alison Kent,, additional, Khuder, Sundos, additional, Kovler, Mark L., additional, Kraus, Courtney L., additional, Krishnamurthy, Ganga, additional, Kukora, Stephanie K., additional, Kumar, Ashok, additional, Kunisaki, Shaun M., additional, Kuper-Sassé, Margaret, additional, Kwiatkowski, David M., additional, Lakshminrusimha, Satyan, additional, Laventhal, Naomi T., additional, Lawrence, Shelley M., additional, Lee-Winn, Angela E., additional, Leuthner, Steven, additional, Lewallen, Laura, additional, Lewis, Tamorah R., additional, Liken, Hillary B., additional, Liubšys, Arūnas, additional, Lui, Kei, additional, Maheshwari, Akhil, additional, Maitre, Nathalie L., additional, Makker, Kartikeya, additional, Mammen, Cherry, additional, J. Martin, Richard, additional, Mattos Castellano, María, additional, Maxwell, Jessie R., additional, McFarlane, Renske, additional, McLemore, Gabrielle, additional, McNelis, Kera M., additional, McPherson, Christopher, additional, Mietzsch, Ulrike, additional, Milante, Rachel R., additional, Miller, Jena L., additional, Mukhopadhyay, Sagori, additional, Mynak, Mimi L., additional, Nasr, Isam W., additional, Natarajan, Niranjana, additional, Navaneethan, Hema, additional, Nees, Shannon N., additional, Nguyen, Mai, additional, Noori, Shahab, additional, Odackal, Namrita J., additional, Ohls, Robin K., additional, Ostrander, Betsy E., additional, Pammi, Mohan, additional, Parimi, Prabhu S., additional, Park, Albert, additional, Patil, Monika S., additional, Pereira, Elaine M., additional, Premkumar, Muralidhar H., additional, Price-Douglas, Webra, additional, Puopolo, Karen M., additional, Rabe, Heike, additional, M. Rahman, Mohammad, additional, Reber, Kristina, additional, Kallem, Venkat Reddy, additional, Repka, Michael X., additional, Rhee, Daniel S., additional, Ringle, Megan L., additional, Rohrer, Allison, additional, Romero, Christopher J., additional, Ryan, Marisa A., additional, Sampah, Maame E.S., additional, Sanchez-Valle, Amarilis, additional, Sant’Anna, Guilherme M., additional, Saugstad, Ola D., additional, RobertH., Anne and, additional, Schacht, John P., additional, Schelonka, Robert L., additional, Schofield, Erin E., additional, Selewski, David T., additional, Shah, Prakesh S., additional, Shih, Jessica G., additional, Sibinga, Erica M.S., additional, Sigal, Winnie, additional, Sims, Brian, additional, Singh, Rachana, additional, Singh, Srijan, additional, Snyder, Donna, additional, Sobrero, Helena, additional, Sponseller, Paul D., additional, Stafstrom, Carl E., additional, Steflik, Heidi J., additional, Sun, Lisa R., additional, Sundararajan, Sripriya, additional, Taylor, Sarah N., additional, Terrin, Norma, additional, Thacker, Prolima G., additional, Thébaud, Bernard, additional, Toms, Rune, additional, Torres, Benjamin A., additional, Tunkel, David E., additional, Umandap, Christine H., additional, Chaves, Diana Vargas, additional, Vento, Maximo, additional, Walsh, Jonathan, additional, Walter, Jolan, additional, Weaver, Meaghann S., additional, Weimer, Kristin, additional, Weller, Jennine, additional, Winter, Lindy W., additional, Wu, Tai-Wei, additional, and Yau, Mabel, additional

Published
2024
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6. The human milk oligosaccharides 2’-fucosyllactose and 6’-sialyllactose protect against the development of necrotizing enterocolitis by inhibiting toll-like receptor 4 signaling

Author

Sodhi, Chhinder P., Wipf, Peter, Yamaguchi, Yukihiro, Fulton, William B., Kovler, Mark, Niño, Diego F., Zhou, Qinjie, Banfield, Emilyn, Werts, Adam D., Ladd, Mitchell R., Buck, Rachael H., Goehring, Karen C., Prindle, Jr, Thomas, Wang, Sanxia, Jia, Hongpeng, Lu, Peng, and Hackam, David J.

Published
2021
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19. Insights image for “The human milk oligosaccharides 2’-fucosyllactose and 6’-sialyllactose protect against the development of necrotizing enterocolitis by inhibiting toll-like receptor 4 signaling.”

Author

Sodhi, Chhinder P., Wipf, Peter, Yamaguchi, Yukihiro, Fulton, William B., Kovler, Mark, Niño, Diego F., Zhou, Qinjie, Banfield, Emilyn, Werts, Adam D., Ladd, Mitchell R., Buck, Rachael H., Goehring, Karen C., Prindle, Jr, Thomas, Wang, Sanxia, Jia, Hongpeng, Lu, Peng, and Hackam, David J.

Published
2021
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23. Mo1670: BIOACTIVE LIPID DIET PREVENTS INJURY AND ENHANCES DEVELOPMENT IN NECROTIZING ENTEROCOLITIS

Author

Lopez, Carla M., primary, Salazar, Andres J. Gonzalez, additional, Kovler, Mark L., additional, Fulton, William B., additional, Yamaguchi, Yukihiro, additional, Wang, Sanxia, additional, Sampah, Maame Efua, additional, Ahmad, Raheel, additional, Kanuri, Sri, additional, Steinway, Steven N., additional, Lu, Peng, additional, Jia, Hongpeng, additional, Sodhi, Chhinder P., additional, and Hackam, David, additional

Published
2022
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25. The administration of a pre-digested fat enriched formula prevents NEC-induced lung injury in mice

Author

Sodhi, Chhinder P., Gonzalez Salazar, Andres J., Kovler, Mark, Fulton, William B., Yamaguchi, Yukihiro, Ishiyama, Asuka, Wang, Sanxia, Prindle, Thomas, Vurma, Mustafa, Das, Tapas, Jia, Hongpeng, Lu, Peng, and Hackam, David J.

Subjects
Food, Formulated, Mice, Disease Models, Animal, Animals, Newborn, Enterocolitis, Necrotizing, Animals, Lung Injury, Reactive Oxygen Species, Article
Abstract

Necrotizing enterocolitis (NEC) is a devastating gastrointestinal disease of prematurity that typically develops after the administration of infant formula, suggesting a link between nutritional components and disease development. One of the most significant complications that develops in patients with NEC is severe lung injury. We have previously shown that the administration of a nutritional formula that is enriched in pre-digested triglycrides that do not require lipase action can significantly reduce the severity of NEC in a mouse model. We now hypothesize that this ‘pre-digested fat system (PDF)’ may reduce NEC-associated lung injury. In support of this hypothesis, we now show that rearing newborn mice on a nutritional formula based on the ‘pre-digested fat (PDF) system’ promotes lung development, as evidenced by increased tight junctions and surfactant protein expression. Mice who were administered this ‘PDF fat system’ were significantly less vulnerable to the development of NEC-induced lung inflammation, and the administration of the ‘PDF fat system’ conferred lung protection. In seeking to define the mechanisms involved, the administration of the PDF system’ significantly enhanced lung maturation and reduced the production of reactive oxygen species (ROS). These findings suggest that the PDF system protects the development of NEC-induced lung injury through effects on lung maturation and reduced reactive oxygen species in the lung, and also increase lung maturation in non-NEC mice.

Published
2021

26. The administration of a pre-digested fat-enriched formula prevents necrotising enterocolitis-induced lung injury in mice

Author

Sodhi, Chhinder P., primary, Gonzalez Salazar, Andres J., additional, Kovler, Mark L., additional, Fulton, William B., additional, Yamaguchi, Yukihiro, additional, Ishiyama, Asuka, additional, Wang, Sanxia, additional, Prindle, Thomas, additional, Vurma, Mustafa, additional, Das, Tapas, additional, Jia, Hongpeng, additional, Lu, Peng, additional, and Hackam, David J., additional

Published
2021
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27. Toll-like receptor 4–mediated enteric glia loss is critical for the development of necrotizing enterocolitis

Author

Kovler, Mark L., primary, Gonzalez Salazar, Andres J., additional, Fulton, William B., additional, Lu, Peng, additional, Yamaguchi, Yukihiro, additional, Zhou, Qinjie, additional, Sampah, Maame, additional, Ishiyama, Asuka, additional, Prindle, Thomas, additional, Wang, Sanxia, additional, Jia, Hongpeng, additional, Wipf, Peter, additional, Sodhi, Chhinder P., additional, and Hackam, David J., additional

Published
2021
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29. The administration of a pre-digested fat-enriched formula prevents necrotising enterocolitis-induced lung injury in mice.

Author

Sodhi, Chhinder P., Gonzalez Salazar, Andres J., Kovler, Mark L., Fulton, William B., Yamaguchi, Yukihiro, Ishiyama, Asuka, Wang, Sanxia, Prindle Jr., Thomas, Vurma, Mustafa, Das, Tapas, Jia, Hongpeng, Lu, Peng, and Hackam, David J.

Subjects
NEONATAL necrotizing enterocolitis, LUNG injuries, BIOLOGICAL models, INFANT formulas, ANIMAL experimentation, INFLAMMATION, TREATMENT effectiveness, REACTIVE oxygen species, DIETARY fats, MICE, DISEASE complications
Abstract

Necrotising enterocolitis (NEC) is a devastating gastrointestinal disease of prematurity that typically develops after the administration of infant formula, suggesting a link between nutritional components and disease development. One of the most significant complications that develops in patients with NEC is severe lung injury. We have previously shown that the administration of a nutritional formula that is enriched in pre-digested Triacylglyceride that do not require lipase action can significantly reduce the severity of NEC in a mouse model. We now hypothesise that this 'pre-digested fat (PDF) system' may reduce NEC-associated lung injury. In support of this hypothesis, we now show that rearing newborn mice on a nutritional formula based on the 'PDF system' promotes lung development, as evidenced by increased tight junctions and surfactant protein expression. Mice that were administered this 'PDF system' were significantly less vulnerable to the development of NEC-induced lung inflammation, and the administration of the 'PDF system' conferred lung protection. In seeking to define the mechanisms involved, the administration of the 'PDF system' significantly enhanced lung maturation and reduced the production of reactive oxygen species (ROS). These findings suggest that the PDF system protects the development of NEC-induced lung injury through effects on lung maturation and reduced ROS in the lung and also increases lung maturation in non-NEC mice. [ABSTRACT FROM AUTHOR]

Published
2022
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31. 573 THE HUMAN MILK OLIGOSACCHARIDES 2’-FUCOSYLLACTOSE AND 6’-SIAYLLACTOSE ATTENUATE NEC-ASSOCIATED BRAIN INJURY

Author

Salazar, Andres J. Gonzalez, primary, Zhou, Qinjie, additional, Kovler, Mark L., additional, Nino, Diego F., additional, Sampah, Maame Efua, additional, Yamaguchi, Yukihiro, additional, Lu, Peng, additional, Jia, Hongpeng, additional, Fulton, William B., additional, Prindle, Thomas, additional, Wang, Sanxia, additional, Buck, Rachael H., additional, Goehring, Karen C., additional, Sodhi, Chhinder P., additional, and Hackam, David, additional

Published
2021
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35. Prolonged In-hospital Time to Appendectomy is Associated With Increased Complicated Appendicitis in Children.

Author

Kovler, Mark L., Pedroso, Felipe E., Etchill, Eric W., Vacek, Jonathan, Bouchard, Megan E., Many, Benjamin T., Raval, Mehul V., and Goldstein, Seth D.

Abstract

Objective: To examine the association between prolonged in-hospital time to appendectomy (TTA) and the risk of complicated appendicitis. Summary Background Data: Historically, acute appendicitis was treated with emergency appendectomy. More recently, practice patterns have shifted to urgent appendectomy, with acceptable in-hospital delays of up to 24 hours. However, the consequences of prolonged TTA remain poorly understood. Herein, we present the largest individual analysis to date of outcomes associated with prolonged in-hospital delay before appendectomy in children. Methods: Data from patients who underwent appendectomy within 24 hours of hospital presentation were obtained from the American College of Surgeons Pediatric National Surgical Quality Improvement Program Procedure Targeted Appendectomy database from 2016 to 2018. Appendectomy within 16 hours of presentation was considered early, whereas those between 16 to 24 hours were defined as late. The primary outcome was operative findings of complicated appendicitis. Secondary outcomes included 30-day complications and resource utilization. Results: This study consisted of 18,927 patients, with 20.6% undergoing late appendectomy. The rate of complicated appendicitis was significantly higher in the late group (Early: 26.3%, Late: 30.3%, P < 0.05). Additionally, the late group had longer operative times, increased need for postoperative percutaneous drainage, antibiotics at discharge, parenteral nutrition, and an extended hospital length of stay (P < 0.05). On multivariate analysis, late appendectomy remained a predictor of complicated disease (odds ratio 1.17 [95% confidence interval, 1.08–1.27]). Conclusions: A significant proportion of pediatric patients with acute appendicitis experience prolonged in-hospital delays before appendectomy, which are associated with modestly increased rates of complicated appendicitis. Although this does not indicate appendectomy needs to be done emergently, prolonged in-hospital TTA should be avoided whenever possible. [ABSTRACT FROM AUTHOR]

Published
2022
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36. Impact of COVID-19 pandemic on injury prevalence and pattern in the Washington, DC Metropolitan Region: a multicenter study by the American College of Surgeons Committee on Trauma, Washington, DC

Author

Chodos, Marc, primary, Sarani, Babak, additional, Sparks, Andrew, additional, Bruns, Brandon, additional, Gupta, Shailvi, additional, Michetti, Christopher P, additional, Crane, Joshua, additional, Hall, Erin, additional, Trankiem, Christine T, additional, Abouassaly, Chadi, additional, Haut, Elliott R, additional, Etchill, Eric, additional, Kovler, Mark L, additional, Williams, Mallory, additional, Zeineddin, Ahmad, additional, and Estroff, Jordan, additional

Published
2021
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40. Insights image for “The human milk oligosaccharides 2’-fucosyllactose and 6’-sialyllactose protect against the development of necrotizing enterocolitis by inhibiting toll-like receptor 4 signaling.”

Author

Sodhi, Chhinder P., primary, Wipf, Peter, additional, Yamaguchi, Yukihiro, additional, Fulton, William B., additional, Kovler, Mark, additional, Niño, Diego F., additional, Zhou, Qinjie, additional, Banfield, Emilyn, additional, Werts, Adam D., additional, Ladd, Mitchell R., additional, Buck, Rachael H., additional, Goehring, Karen C., additional, Prindle, Thomas, additional, Wang, Sanxia, additional, Jia, Hongpeng, additional, Lu, Peng, additional, and Hackam, David J., additional

Published
2020
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44. The human milk oligosaccharides 2’-fucosyllactose and 6’-sialyllactose protect against the development of necrotizing enterocolitis by inhibiting toll-like receptor 4 signaling

Author

Sodhi, Chhinder P., primary, Wipf, Peter, additional, Yamaguchi, Yukihiro, additional, Fulton, William B., additional, Kovler, Mark, additional, Niño, Diego F., additional, Zhou, Qinjie, additional, Banfield, Emilyn, additional, Werts, Adam D., additional, Ladd, Mitchell R., additional, Buck, Rachael H., additional, Goehring, Karen C., additional, Prindle, Thomas, additional, Wang, Sanxia, additional, Jia, Hongpeng, additional, Lu, Peng, additional, and Hackam, David J., additional

Published
2020
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46. A Dynamic Variation of Pulmonary ACE2 Is Required to Modulate Neutrophilic Inflammation in Response to Pseudomonas aeruginosa Lung Infection in Mice

Author

Sodhi, Chhinder P., primary, Nguyen, Jenny, additional, Yamaguchi, Yukihiro, additional, Werts, Adam D., additional, Lu, Peng, additional, Ladd, Mitchell R., additional, Fulton, William B., additional, Kovler, Mark L., additional, Wang, Sanxia, additional, Prindle, Thomas, additional, Zhang, Yong, additional, Lazartigues, Eric D., additional, Holtzman, Michael J., additional, Alcorn, John F., additional, Hackam, David J., additional, and Jia, Hongpeng, additional

Published
2019
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