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The contribution deals with the simulation of the transitional flows with heat transfer by means the EARSM turbulence model of Hellsten [1] completed by the algebraic transition model of Straka and Příhoda [2] and by the three-equation model of Walters and Cokjlat [3]. The both mathematical models were tested for the flat plate flow on a heated wall measured by Sohn and Reshotko [16] and then applied to the simulation of compressible flow through the VKI turbine blade cascade according to measurements of Arts et al. [4]. The simulations were carried out for subsonic and transonic regimes at various free-stream turbulence levels. The best agreement of numerical results with experimental data was achieved by the URANS approach applied for the EARSM model with the algebraic transition model giving good results for both subsonic and transonic regimes as well.

Insertions in the protease (PR) region of human immunodeficiency virus (HIV) represent an interesting mechanism of antiviral resistance against HIV PR inhibitors (PIs). Here, we demonstrate the improved ability of a phosphonate-containing experimental HIV PI, GS-8374, relative to that of other PIs, to effectively inhibit patient-derived recombinant HIV strains bearing PR insertions and numerous other mutations. We correlate enzyme inhibition with the catalytic activities of corresponding recombinant PRs in vitro and provide a biochemical and structural analysis of the PR-inhibitor complex.