1. Anti-phospholipid human monoclonal antibodies inhibit CCR5-tropic HIV-1 and induce β-chemokines
- Author
-
Moody, M Anthony, Liao, Hua-Xin, Alam, S Munir, Scearce, Richard M, Plonk, M Kelly, Kozink, Daniel M, Drinker, Mark S, Zhang, Ruijun, Xia, Shi-Mao, Sutherland, Laura L, Tomaras, Georgia D, Giles, Ian P, Kappes, John C, Ochsenbauer-Jambor, Christina, Edmonds, Tara G, Soares, Melina, Barbero, Gustavo, Forthal, Donald N, Landucci, Gary, Chang, Connie, King, Steven W, Kavlie, Anita, Denny, Thomas N, Hwang, Kwan-Ki, Chen, Pojen P, Thorpe, Philip E, Montefiori, David C, and Haynes, Barton F
- Subjects
Infectious Diseases ,Clinical Research ,Immunization ,Biotechnology ,HIV/AIDS ,Development of treatments and therapeutic interventions ,5.1 Pharmaceuticals ,Infection ,Antibodies ,Antiphospholipid ,Antibodies ,Monoclonal ,CD4-Positive T-Lymphocytes ,Cardiolipins ,Cell Fusion ,Chemokine CCL3 ,Chemokine CCL4 ,Chemokines ,Chemokines ,CC ,Complementarity Determining Regions ,Culture Media ,Conditioned ,Endotoxins ,Epithelial Cells ,Giant Cells ,HIV-1 ,Humans ,Immunity ,Innate ,Immunoglobulin Fab Fragments ,Immunoglobulin Fc Fragments ,Kinetics ,Leukocytes ,Mononuclear ,Monocytes ,Mutation ,Phosphatidylethanolamines ,Phosphatidylserines ,Receptors ,CCR5 ,Viral Tropism ,Virus Internalization ,beta 2-Glycoprotein I ,env Gene Products ,Human Immunodeficiency Virus ,Medical and Health Sciences ,Immunology - Abstract
Traditional antibody-mediated neutralization of HIV-1 infection is thought to result from the binding of antibodies to virions, thus preventing virus entry. However, antibodies that broadly neutralize HIV-1 are rare and are not induced by current vaccines. We report that four human anti-phospholipid monoclonal antibodies (mAbs) (PGN632, P1, IS4, and CL1) inhibit HIV-1 CCR5-tropic (R5) primary isolate infection of peripheral blood mononuclear cells (PBMCs) with 80% inhibitory concentrations of
- Published
- 2010