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163 results on '"Krüll, Matthias"'

1. Effects of inhaled beclometasone dipropionate/formoterol fumarate/glycopyrronium vs. beclometasone dipropionate/formoterol fumarate and placebo on lung hyperinflation and exercise endurance in chronic obstructive pulmonary disease: a randomised controlled trial

Author

Watz, Henrik, Kirsten, Anne-Marie, Ludwig-Sengpiel, Andrea, Krüll, Matthias, Mroz, Robert M., Georges, George, Varoli, Guido, Charretier, Rémi, Cortellini, Mauro, Vele, Andrea, and Galkin, Dmitry

Published
2024
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4. Fixed-dose combination of indacaterol/glycopyrronium/mometasone furoate once-daily versus salmeterol/fluticasone twice-daily plus tiotropium once-daily in patients with uncontrolled asthma: A randomised, Phase IIIb, non-inferiority study (ARGON)

Author

Gessner, Christian, Kornmann, Oliver, Maspero, Jorge, van Zyl-Smit, Richard, Krüll, Matthias, Salina, Anna, Gupta, Pritam, Bostel, Sebastien, Fucile, Sebastian, Conde, Lorena Garcia, and Pfister, Pascal

Published
2020
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10. Corrigendum to “Fixed-dose combination of indacaterol/glycopyrronium/mometasone furoate once-daily versus salmeterol/fluticasone twice-daily plus tiotropium once-daily in patients with uncontrolled asthma: A randomised, Phase IIIb, non-inferiority study (ARGON)” [Respir. Med. 170 (Aug-Sep 2020) 106021]

Author

Gessner, Christian, Kornmann, Oliver, Maspero, Jorge, van Zyl-Smit, Richard, Krüll, Matthias, Salina, Anna, Gupta, Pritam, Bostel, Sebastien, Fucile, Sebastian, Conde, Lorena Garcia, and Pfister, Pascal

Published
2020
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15. Lower ICS dose effect on symptoms and rescue medication use of indacaterol/glycopyrronium/mometasone (IND/GLY/MF) medium-dose vs salmeterol/fluticasone (Sal/Flu) high-dose plus tiotropium (Tio): ARGON study

Author

Gessner, Christian, primary, Kornmann, Oliver, additional, Maspero, Jorge, additional, Zyl-Smit, Richard Van, additional, Krüll, Matthias, additional, Sojo, Agustín, additional, Salina, Anna, additional, Gupta, Pritam, additional, and Conde, Lorena Garcia, additional

Published
2020
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17. Is allergy immunotherapy with birch sufficient to treat patients allergic to pollen of tree species of the birch homologous group?

Author

Kleine‐Tebbe, Jörg, primary, Zuberbier, Torsten, additional, Werfel, Thomas, additional, Krüll, Matthias, additional, Wagenmann, Martin, additional, Johansen, Niels, additional, Adler Würtzen, Peter, additional, Wolf, Hendrik, additional, Mücke, Victoria, additional, Wüstenberg, Eike, additional, and Biedermann, Tilo, additional

Published
2020
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23. Rate of cardiac arrhythmias and silent brain lesions in experienced marathon runners: rationale, design and baseline data of the Berlin Beat of Running study

Author

Haeusler Karl, Herm Juliane, Kunze Claudia, Krüll Matthias, Brechtel Lars, Lock Jürgen, Hohenhaus Marc, Heuschmann Peter U, Fiebach Jochen B, Haverkamp Wilhelm, Endres Matthias, and Jungehulsing Gerhard

Subjects
Marathon running, ECG-recording, Magnetic resonance imaging, Blood sampling, Cardiac arrhythmia, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Abstract Background Regular exercise is beneficial for cardiovascular health but a recent meta-analysis indicated a relationship between extensive endurance sport and a higher risk of atrial fibrillation, an independent risk factor for stroke. However, data on the frequency of cardiac arrhythmias or (clinically silent) brain lesions during and after marathon running are missing. Methods/ Design In the prospective observational “Berlin Beat of Running” study experienced endurance athletes underwent clinical examination (CE), 3 Tesla brain magnetic resonance imaging (MRI), carotid ultrasound imaging (CUI) and serial blood sampling (BS) within 2-3 days prior (CE, MRI, CUI, BS), directly after (CE, BS) and within 2 days after (CE, MRI, BS) the 38th BMW BERLIN-MARATHON 2011. All participants wore a portable electrocardiogram (ECG)-recorder throughout the 4 to 5 days baseline study period. Participants with pathological MRI findings after the marathon, troponin elevations or detected cardiac arrhythmias will be asked to undergo cardiac MRI to rule out structural abnormalities. A follow-up is scheduled after one year. Results Here we report the baseline data of the enrolled 110 athletes aged 36-61 years. Their mean age was 48.8 ± 6.0 years, 24.5% were female, 8.2% had hypertension and 2.7% had hyperlipidaemia. Participants have attended a mean of 7.5 ± 6.6 marathon races within the last 5 years and a mean of 16 ± 36 marathon races in total. Their weekly running distance prior to the 38th BMW BERLIN-MARATHON was 65 ± 17 km. Finally, 108 (98.2%) Berlin Beat-Study participants successfully completed the 38th BMW BERLIN-MARATHON 2011. Discussion Findings from the “Berlin Beats of Running” study will help to balance the benefits and risks of extensive endurance sport. ECG-recording during the marathon might contribute to identify athletes at risk for cardiovascular events. MRI results will give new insights into the link between physical stress and brain damage. Trial registration clinicaltrials.gov NCT01428778

Published
2012
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24. MRI Brain Changes After Marathon Running: Results of the Berlin Beat of Running Study

Author

Herm, Juliane, additional, Haeusler, Karl Georg, additional, Kunze, Claudia, additional, Krüll, Matthias, additional, Brechtel, Lars, additional, Lock, Jürgen, additional, Heuschmann, Peter U., additional, Haverkamp, Wilhelm, additional, Heekeren, Hauke, additional, Liman, Thomas, additional, Endres, Matthias, additional, Fiebach, Jochen B., additional, and Jungehulsing, Gerhard Jan, additional

Published
2019
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28. Marathon running increases circulating endothelial- and thrombocyte-derived microparticles

Author

Schwarz, Viktoria, primary, Düsing, Philip, additional, Liman, Thomas, additional, Werner, Christian, additional, Herm, Juliane, additional, Bachelier, Katrin, additional, Krüll, Matthias, additional, Brechtel, Lars, additional, Jungehulsing, Gerhard J, additional, Haverkamp, Wilhelm, additional, Böhm, Michael, additional, Endres, Matthias, additional, Haeusler, Karl Georg, additional, and Laufs, Ulrich, additional

Published
2017
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29. Frequency of exercise-induced ST-T-segment deviations and cardiac arrhythmias in recreational endurance athletes during a marathon race: results of the prospective observational Berlin Beat of Running study

Author

Herm, Juliane, primary, Töpper, Agnieszka, additional, Wutzler, Alexander, additional, Kunze, Claudia, additional, Krüll, Matthias, additional, Brechtel, Lars, additional, Lock, Jürgen, additional, Fiebach, Jochen B, additional, Heuschmann, Peter U, additional, Haverkamp, Wilhelm, additional, Endres, Matthias, additional, Jungehulsing, Gerhard Jan, additional, and Haeusler, Karl Georg, additional

Published
2017
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34. Pathogenesis of Chlamydophila pneumoniae-mediated diseases

Author

Krüll, Matthias

Subjects
signal-transduction, Chlamydophila, pneumonia, Nod-proteins, endothelial-cell, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit, respiratory tract diseases
Abstract

Titelblatt und Inhaltsverzeichnis Einleitung Arbeitshypothesen Ergebnisse Diskussion Zusammenfassung Literaturverzeichnis, Chlamydophila (Chlamydia) pneumoniae, a Gram-negative obligate intracellular bacterium, is a widespread respiratory pathogen causing sinusitis, pharyngitis, bronchitis and pneumonia. Repetitive or chronic persistent infections as a trigger/promoter of inflammation have been associated with an increased risk for asthma, chronic obstructive pulmonary disease (COPD) or vascular lesions. Although the genome of C. pneumoniae has been sequenced completely this information has not led yet to an understanding of the mechanisms of infection and target cell activation nor to the identification of potential chlamydial virulence factors. This work will give an overview on the pathogenesis of C. pneumoniae-induced acute and chronic infections. It will especially focus on mechanisms of target cell activation via putative host cell receptors and subsequently activated signal transduction pathways in epithelial and endothelial cells., Chlamydophila (Chlamydia) pneumoniae, ein weitverbreitetes Gram-negatives, obligat intrazelluläres Bakterium, ist ein häufiger Erreger respiratorischer Infektionen. Neben Bronchitiden, Sinusitiden und Pharyngitiden kann C. pneumoniae eine sogenannte atypische, lymphozytär geprägte Pneumonie hervorrufen. Repetitive/rezidivierende oder persistierende Infektionen mit C. pneumoniae werden als pathogenetisch bedeutsam für die Entwicklung chronischer respiratorischer Erkrankungen (Asthma bronchiale, chronisch obstruktive Bronchitis/COPD) sowie vaskulärer Läsionen mit dem vermehrten Auftreten von koronarer Herzkrankheit (KHK) und Arteriosklerose betrachtet. Obwohl das Genom von C. pneumoniae seit 1999 vollständig sequenziert ist, sind die Mechanismen der Wirtszellinfektion (Adhäsion, Invasion) und -aktivierung sowie die Bedeutung verschiedener chlamydialer Virulenzfaktoren weitgehend offen. Diese Arbeit gibt eine Übersicht über die Pathogenese akuter und chronischer C. pneumoniae-assoziierter Erkrankungen und fokussiert hierbei insbesondere auf die Mechanismen der Zielzellinfektion über potentielle Wirtszellrezeptoren sowie die nachfolgend aktivierten Signalübertragungswege in Epithel- und Endothelzellen.

Published
2007
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36. Wertigkeit ausgewählter Eisenstoffwechselparameter im Ausdauersport

Author

Röcker, Lothar, Wolff, Roland, Krüll, Matthias, Brachmann, Steffi, Röcker, Lothar, Wolff, Roland, Krüll, Matthias, and Brachmann, Steffi

Abstract

Einleitung: Eisenmangel ist ein häufiges Problem bei Ausdauersportlern, da dieser die Leistungsfähigkeit einschränken und zu einer Blutanämie führen kann. Von den klassischen Eisenstoffwechselparametern sind nur wenige geeignet, den tatsächlichen Eisenstatus anzuzeigen, da sie durch sportliche Aktivität per se beeinflusst werden können. In der Studie wird die Wertigkeit moderner Eisenstoffwechselparameter im Ausdauersport untersucht. Ergebnisse und Diskussion: Der Hämoglobingehalt der Retikulozyten (CHr) und der prozentuale Anteil der hypochromen Erythrozyten (% HYPO) bleiben als moderne Parameter der Eisenstoffwechseldiagnostik auch nach regenerativen, extensiven sowie intensiven Ausdauerbelastungen konstant. Sie zeigen somit unbeeinflusst von der (Ausdauer-)Sportart als auch von der Belastungsdauer und –intensität die aktuelle Eisenversorgung der Erythropoese im Knochenmark an. Als Monitoringparameter im Rahmen einer Eisensubstitution sind der CHr sowie der prozentuale Anteil hypochromer Retikulozyten sensible Parameter, mit denen sich schnell und zuverlässig die Effektivität einer oralen Eisensubstitution nachweisen lässt. Der Eisenstatus kann durch die alleinige Bestimmung des CHr bzw. des % HYPO nicht exakt ermittelt werden. Im Gegensatz zum Einsatz bei klinischen Fragestellungen können sie zu diesem Zeitpunkt in der Sportmedizin allenfalls nur ein ergänzender Parameter in der Differentialdiagnostik eines Eisenmangels sein. Die für Ausdauersportler ermittelten Referenzwerte liegen bei 28,8-35,9 pg für den CHr und bei 0-0,5 % für die hypochromen Erythrozyten. Ein belastungsbedingter Anstieg des Eisen-regulierenden Hormons Hepcidin könnte auf Grund seiner inhibitorischen Wirkung auf die intestinale Eisenabsorption sowie auf die Freisetzung von Eisen aus den Makrophagen zur Entwicklung von Eisenmangel-zuständen führen. Die Entwicklung von Hepcidin-Antagonisten könnte in Zukunft therapeutische Anwendungen finden., Introduction: Athletes are commonly diagnosed with iron deficiency, particularly those involved in endurance sports. It often not only decreases athletic performance but also contributes to the development of anaemia. Many biochemical markers are used to evaluate body iron stores but some of them are affected by physical exercises. This study was designed to investigate new haematological parameters in endurance athletes. Results and discussion: Reticulocyte hemoglobin content (CHr) and percentage of hypochromic red cells (% HYPO) were highly stable in athletes subjected to varying physical loads. Furthermore, they were neither affected by different forms of endurance sports nor by their duration and intensity. These modern indices are able to reflect the availability of iron during erythropoiesis at all times. In the early prediction of response to oral iron supplementation, the reticulocyte indices CHr and % HYPOr (percentage of hypochromic reticulocytes) are the most sensitive parameters. However, it is not possible to assess the iron status in athletes by CHr and % HYPO alone. In contrast to other clinical cases they can only be an additional parameter in the differential diagnosis of iron deficiency. The calculated reference range for endurance athletes are 28,8 - 35,9 pg for CHr and 0-0,5 % for % HYPO. As the iron-regulating hormone hepcidin is inhibiting the absorption of iron from the diet at the site of the duodenal enterocytes and blocking the release of iron from macrophages that have collected senescent erythrocytes, an exercise induced up-regulation of hepcidin activity might potentially be a new mechanism causing iron deficiency in athletes. Therefore, the development of hepcidin antagonists could prove to be helpful with regard to therapeutic utilization.

Published
2011

37. Schädigt Nitrox die Lunge von Sporttauchern?

Author

Zenské, Andre, Krüll, Matthias, Muth, Thomas, and Schipke, Jochen D.

Abstract

Copyright of ErgoMed is the property of Dr. Curt Haefner-Verlag GmbH and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2017

39. Essential Role of Mitochondrial Antiviral Signaling, IFN Regulatory Factor (IRF)3, and IRF7 in Chlamydophila pneumoniae-Mediated IFN-β Response and Control of Bacterial Replication in Human Endothelial Cells

Author

Buß, Claudia, primary, Opitz, Bastian, additional, Hocke, Andreas C., additional, Lippmann, Juliane, additional, van Laak, Vincent, additional, Hippenstiel, Stefan, additional, Krüll, Matthias, additional, Suttorp, Norbert, additional, and Eitel, Julia, additional

Published
2010
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41. Simvastatin Reduces Chlamydophila pneumoniae –Mediated Histone Modifications and Gene Expression in Cultured Human Endothelial Cells

Author

Schmeck, Bernd, primary, Beermann, Wiebke, additional, N’Guessan, Philippe Dje, additional, Hocke, Andreas C., additional, Opitz, Bastian, additional, Eitel, Julia, additional, Dinh, Quoc Thai, additional, Witzenrath, Martin, additional, Krüll, Matthias, additional, Suttorp, Norbert, additional, and Hippenstiel, Stefan, additional

Published
2008
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42. Mechanisms ofChlamydophila pneumoniae–Mediated GM-CSF Release in Human Bronchial Epithelial Cells

Author

Krüll, Matthias, primary, Bockstaller, Petra, additional, Wuppermann, Frederik N., additional, Klucken, Andrea C., additional, Mühling, Jörg, additional, Schmeck, Bernd, additional, Seybold, Joachim, additional, Walter, Clemens, additional, Maass, Matthias, additional, Rosseau, Simone, additional, Hegemann, Johannes H., additional, Suttorp, Norbert, additional, and Hippenstiel, Stefan, additional

Published
2006
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45. Moraxella catarrhalis–Infected Alveolar Epithelium Induced Monocyte Recruitment and Oxidative Burst

Author

Rosseau, Simone, primary, Wiechmann, Kristina, additional, Moderer, Stefanie, additional, Selhorst, Jochen, additional, Mayer, Konstantin, additional, Krüll, Matthias, additional, Hocke, Andreas, additional, Slevogt, Hortense, additional, Seeger, Werner, additional, Suttorp, Norbert, additional, Seybold, Joachim, additional, and Lohmeyer, Jürgen, additional

Published
2005
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46. Porphyromonas gingivalis Strain-Dependent Activation of Human Endothelial Cells

Author

Walter, Clemens, primary, Zahlten, Janine, additional, Schmeck, Bernd, additional, Schaudinn, Christoph, additional, Hippenstiel, Stefan, additional, Frisch, Eckehard, additional, Hocke, Andreas C., additional, Pischon, Nicole, additional, Kuramitsu, Howard K., additional, Bernimoulin, Jean-Pierre, additional, Suttorp, Norbert, additional, and Krüll, Matthias, additional

Published
2004
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49. Pathogenesis of Chlamydophila pneumoniae infections — epidemiology, immunity, cell biology, virulence factors.

Author

Schmidt, Axel, Wolff, Manfred H., Kaufmann, Stefan H.E., Welte, Tobias, Marre, Reinhard, Krüll, Matthias, and Suttorp, Norbert

Abstract

Chlamydophila (Chlamydia) pneumoniae, a Gram-negative obligate intracellular bacterium, is a widespread respiratory pathogen causing sinusitis, pharyngitis, bronchitis and pneumonia. Repetitive or chronic persistent infections have been associated with an increased risk for asthma, chronic obstructive pulmonary disease (COPD) or vascular lesions. Although the genome of C. pneumoniae has been sequenced completely this information has not led yet to an understanding of the mechanisms of infection and target cell activation nor to the identification of potential chlamydial virulence factors. In this review we will give an overview on the pathogenesis of C. pneumoniae-induced acute and chronic infections. [ABSTRACT FROM AUTHOR]

Published
2007
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50. Adrenomedullin Reduces Endothelial Hyperpermeability

Author

Hippenstiel, Stefan, primary, Witzenrath, Martin, additional, Schmeck, Bernd, additional, Hocke, Andreas, additional, Krisp, Mathias, additional, Krüll, Matthias, additional, Seybold, Joachim, additional, Seeger, Werner, additional, Rascher, Wolfgang, additional, Schütte, Hartwig, additional, and Suttorp, Norbert, additional

Published
2002
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