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1. The genomic evolutionary dynamics and global circulation patterns of respiratory syncytial virus.

Author

Langedijk, Annefleur, Vrancken, Bram, Lebbink, Robert, Wilkins, Deidre, Kelly, Elizabeth, Baraldi, Eugenio, Mascareñas de Los Santos, Abiel, Danilenko, Daria, Choi, Eun, Palomino, María, Chi, Hsin, Keller, Christian, Cohen, Robert, Papenburg, Jesse, Pernica, Jeffrey, Greenough, Anne, Richmond, Peter, Martinón-Torres, Federico, Heikkinen, Terho, Stein, Renato, Hosoya, Mitsuaki, Nunes, Marta, Verwey, Charl, Evers, Anouk, Kragten-Tabatabaie, Leyla, Suchard, Marc, Kosakovsky Pond, Sergei, Poletto, Chiara, Colizza, Vittoria, Lemey, Philippe, and Bont, Louis

Subjects
Infant, Child, Humans, Child, Preschool, Respiratory Syncytial Virus Infections, Phylogeny, Respiratory Syncytial Virus, Human, Genomics, Respiratory Tract Infections
Abstract

Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory tract infection in young children and the second leading cause of infant death worldwide. While global circulation has been extensively studied for respiratory viruses such as seasonal influenza, and more recently also in great detail for SARS-CoV-2, a lack of global multi-annual sampling of complete RSV genomes limits our understanding of RSV molecular epidemiology. Here, we capitalise on the genomic surveillance by the INFORM-RSV study and apply phylodynamic approaches to uncover how selection and neutral epidemiological processes shape RSV diversity. Using complete viral genome sequences, we show similar patterns of site-specific diversifying selection among RSVA and RSVB and recover the imprint of non-neutral epidemic processes on their genealogies. Using a phylogeographic approach, we provide evidence for air travel governing the global patterns of RSVA and RSVB spread, which results in a considerable degree of phylogenetic mixing across countries. Our findings highlight the potential of systematic global RSV genomic surveillance for transforming our understanding of global RSV spread.

Published
2024

2. Nirsevimab binding-site conservation in respiratory syncytial virus fusion glycoprotein worldwide between 1956 and 2021: an analysis of observational study sequencing data

Author

Clement, Pascale, Gupta, Atul, Hashimoto, Koichi, Komissarova, Kseniya, Laubscher, Matt, Lumertz, Magali, Priante, Elena, Rivero-Calle, Irene, Wadia, Ushma, Yun, Ki Wook, Wilkins, Deidre, Langedijk, Annefleur C, Lebbink, Robert Jan, Morehouse, Christopher, Abram, Michael E, Ahani, Bahar, Aksyuk, Anastasia A, Baraldi, Eugenio, Brady, Tyler, Chen, Albert Tian, Chi, Hsin, Choi, Eun Hwa, Cohen, Robert, Danilenko, Daria M, Gopalakrishnan, Vancheswaran, Greenough, Anne, Heikkinen, Terho, Hosoya, Mitsuaki, Keller, Christian, Kelly, Elizabeth J, Kragten-Tabatabaie, Leyla, Martinón-Torres, Federico, de Los Santos, Abiel Homero Mascareñas, Nunes, Marta C, Palomino, María Angélica, Papenburg, Jesse, Pernica, Jeffrey M, Richmond, Peter, Stein, Renato T, Tuffy, Kevin M, Verwey, Charl, Esser, Mark T, Tabor, David E, and Bont, Louis J

Published
2023
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3. Respiratory syncytial virus prevention within reach: the vaccine and monoclonal antibody landscape

Author

Mazur, Natalie I, Terstappen, Jonne, Baral, Ranju, Bardají, Azucena, Beutels, Philippe, Buchholz, Ursula J, Cohen, Cheryl, Crowe, James E, Jr, Cutland, Clare L, Eckert, Linda, Feikin, Daniel, Fitzpatrick, Tiffany, Fong, Youyi, Graham, Barney S, Heikkinen, Terho, Higgins, Deborah, Hirve, Siddhivinayak, Klugman, Keith P, Kragten-Tabatabaie, Leyla, Lemey, Philippe, Libster, Romina, Löwensteyn, Yvette, Mejias, Asuncion, Munoz, Flor M, Munywoki, Patrick K, Mwananyanda, Lawrence, Nair, Harish, Nunes, Marta C, Ramilo, Octavio, Richmond, Peter, Ruckwardt, Tracy J, Sande, Charles, Srikantiah, Padmini, Thacker, Naveen, Waldstein, Kody A, Weinberger, Dan, Wildenbeest, Joanne, Wiseman, Dexter, Zar, Heather J, Zambon, Maria, and Bont, Louis

Published
2023
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5. Parent's perception of respiratory syncytial virus and subsequent wheezing burden: A multi‐country cross‐sectional survey

Author

Custovic, Adnan, Mestre‐ferrandiz, Jorge, Kragten‐tabatabaie, Leyla, Laurent, Julie, Sellem, Laury, Koslap‐petraco, Mary, Cadeddu, Chiara, Cadeddu, Chiara (ORCID:0000-0003-0149-1078), Custovic, Adnan, Mestre‐ferrandiz, Jorge, Kragten‐tabatabaie, Leyla, Laurent, Julie, Sellem, Laury, Koslap‐petraco, Mary, Cadeddu, Chiara, and Cadeddu, Chiara (ORCID:0000-0003-0149-1078)

Abstract

Background: Respiratory Syncytial Virus (RSV) is the leading cause of hospitalization in infants. RSV bronchiolitis is associated with an increased risk of subsequent wheezing. We aimed to document the parents' perception of the link between RSV infection and subsequent wheezing, wheezing-related healthcare and family resources use, and its impact on family daily life. Methods: This cross-sectional online survey enrolled 1200 parents with at least one child <= 6y living in the United States, United Kingdom, Spain, and Italy. Children diagnosed with RSV bronchiolitis before age of 2 years were included in the RSV group, and those never diagnosed with RSV bronchiolitis in the Reference group. Results: The odds of wheezing were 4.5-fold (95%CI 3.5-5.9) higher in the RSV than in the Reference group. The odds increased to 7.7-fold (95%CI 5.4-11.1) among children who were hospitalized, and 9-fold (95%CI 5.1-16.6) among those admitted to pediatric intensive care with RSV bronchiolitis. Similar trends were observed across all countries. In total, 57% of parents reported their child's wheezing to have moderate to severe impact on their emotional well-being, and 53% on their daily life activities and/or social life. 64% of parents reported moderate-severe impact of wheezing on child's quality of sleep and 49% and 46% reported a moderate-severe impact on their children's emotional well-being and physical activities. Conclusions: This survey suggests an association between RSV infection and subsequent wheezing in children across different countries. Wheezing, especially in association with RSV infection, was associated with increased healthcare utilization and costs, and significantly impacted parents' and children daily life.

Published
2024

6. Parent's perception of respiratory syncytial virus and subsequent wheezing burden:A multi-country cross-sectional survey

Author

Custovic, Adnan, Mestre-Ferrandiz, Jorge, Kragten-Tabatabaie, Leyla, Laurent, Julie, Sellem, Laury, Koslap-Petraco, Mary, Cadeddu, Chiara, Custovic, Adnan, Mestre-Ferrandiz, Jorge, Kragten-Tabatabaie, Leyla, Laurent, Julie, Sellem, Laury, Koslap-Petraco, Mary, and Cadeddu, Chiara

Abstract

Background: Respiratory Syncytial Virus (RSV) is the leading cause of hospitalization in infants. RSV bronchiolitis is associated with an increased risk of subsequent wheezing. We aimed to document the parents' perception of the link between RSV infection and subsequent wheezing, wheezing-related healthcare and family resources use, and its impact on family daily life. Methods: This cross-sectional online survey enrolled 1200 parents with at least one child ≤6y living in the United States, United Kingdom, Spain, and Italy. Children diagnosed with RSV bronchiolitis before age of 2 years were included in the RSV group, and those never diagnosed with RSV bronchiolitis in the Reference group. Results: The odds of wheezing were 4.5-fold (95%CI 3.5–5.9) higher in the RSV than in the Reference group. The odds increased to 7.7-fold (95%CI 5.4–11.1) among children who were hospitalized, and 9-fold (95%CI 5.1–16.6) among those admitted to pediatric intensive care with RSV bronchiolitis. Similar trends were observed across all countries. In total, 57% of parents reported their child's wheezing to have moderate to severe impact on their emotional well-being, and 53% on their daily life activities and/or social life. 64% of parents reported moderate–severe impact of wheezing on child's quality of sleep and 49% and 46% reported a moderate–severe impact on their children's emotional well-being and physical activities. Conclusions: This survey suggests an association between RSV infection and subsequent wheezing in children across different countries. Wheezing, especially in association with RSV infection, was associated with increased healthcare utilization and costs, and significantly impacted parents' and children daily life.

Published
2024

7. The genomic evolutionary dynamics and global circulation patterns of respiratory syncytial virus

Author

Langedijk, Annefleur A.C., Vrancken, Bram, Lebbink, Robert Jan, Wilkins, Deidre, Kelly, Elizabeth E.J., Baraldi, Eugenio, Mascareñas de Los Santos, Abiel Homero, Danilenko, Daria D.M., Choi, Eun Hwa, Palomino, María Angélica, Chi, Hsin, Keller, Christian, Cohen, Robert, Papenburg, Jesse, Pernica, Jeffrey, Greenough, Anne, Richmond, Peter, Martinón-Torres, Federico, Heikkinen, Terho, Stein, Renato Tetelbom, Hosoya, Mitsuaki, Nunes, Marta M.C., Verwey, Charl, Evers, Anouk, Kragten-Tabatabaie, Leyla, Suchard, Marc M.A., Kosakovsky Pond, Sergei S.L., Poletto, Chiara, Colizza, Vittoria, Lemey, Philippe, Bont, Louis, Langedijk, Annefleur A.C., Vrancken, Bram, Lebbink, Robert Jan, Wilkins, Deidre, Kelly, Elizabeth E.J., Baraldi, Eugenio, Mascareñas de Los Santos, Abiel Homero, Danilenko, Daria D.M., Choi, Eun Hwa, Palomino, María Angélica, Chi, Hsin, Keller, Christian, Cohen, Robert, Papenburg, Jesse, Pernica, Jeffrey, Greenough, Anne, Richmond, Peter, Martinón-Torres, Federico, Heikkinen, Terho, Stein, Renato Tetelbom, Hosoya, Mitsuaki, Nunes, Marta M.C., Verwey, Charl, Evers, Anouk, Kragten-Tabatabaie, Leyla, Suchard, Marc M.A., Kosakovsky Pond, Sergei S.L., Poletto, Chiara, Colizza, Vittoria, Lemey, Philippe, and Bont, Louis

Abstract

Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory tract infection in young children and the second leading cause of infant death worldwide. While global circulation has been extensively studied for respiratory viruses such as seasonal influenza, and more recently also in great detail for SARS-CoV-2, a lack of global multi-annual sampling of complete RSV genomes limits our understanding of RSV molecular epidemiology. Here, we capitalise on the genomic surveillance by the INFORM-RSV study and apply phylodynamic approaches to uncover how selection and neutral epidemiological processes shape RSV diversity. Using complete viral genome sequences, we show similar patterns of site-specific diversifying selection among RSVA and RSVB and recover the imprint of non-neutral epidemic processes on their genealogies. Using a phylogeographic approach, we provide evidence for air travel governing the global patterns of RSVA and RSVB spread, which results in a considerable degree of phylogenetic mixing across countries. Our findings highlight the potential of systematic global RSV genomic surveillance for transforming our understanding of global RSV spread., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2024

8. Respiratory Syncytial Virus Seasonality : A Global Overview

Author

Obando-Pacheco, Pablo, Justicia-Grande, Antonio José, Rivero-Calle, Irene, Rodríguez-Tenreiro, Carmen, Sly, Peter, Ramilo, Octavio, Mejías, Asunción, Baraldi, Eugenio, Papadopoulos, Nikolaos G., Nair, Harish, Nunes, Marta C., Kragten-Tabatabaie, Leyla, Heikkinen, Terho, Greenough, Anne, Stein, Renato T., Manzoni, Paolo, Bont, Louis, and Martinón-Torres, Federico

Published
2018

9. The respiratory syncytial virus vaccine landscape: lessons from the graveyard and promising candidates

Author

Mazur, Natalie I, Higgins, Deborah, Nunes, Marta C, Melero, José A, Langedijk, Annefleur C, Horsley, Nicole, Buchholz, Ursula J, Openshaw, Peter J, McLellan, Jason S, Englund, Janet A, Mejias, Asuncion, Karron, Ruth A, Simões, Eric AF, Knezevic, Ivana, Ramilo, Octavio, Piedra, Pedro A, Chu, Helen Y, Falsey, Ann R, Nair, Harish, Kragten-Tabatabaie, Leyla, Greenough, Anne, Baraldi, Eugenio, Papadopoulos, Nikolaos G, Vekemans, Johan, Polack, Fernando P, Powell, Mair, Satav, Ashish, Walsh, Edward E, Stein, Renato T, Graham, Barney S, and Bont, Louis J

Published
2018
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10. Global molecular diversity of RSV – the “INFORM RSV” study

Author

Langedijk, Annefleur C., Lebbink, Robert Jan, Naaktgeboren, Christiana, Evers, Anouk, Viveen, Marco C., Greenough, Anne, Heikkinen, Terho, Stein, Renato T., Richmond, Peter, Martinón-Torres, Federico, Nunes, Marta, Hosoya, Mitsuaki, Keller, Christian, Bauck, Monika, Cohen, Robert, Papenburg, Jesse, Pernica, Jeffrey, Hennus, Marije P., Jin, Hong, Tabor, David E., Tovchigrechko, Andrev, Ruzin, Alexey, Abram, Michael E., Wilkins, Deidre, Wildenbeest, Joanne G., Kragten-Tabatabaie, Leyla, Coenjaerts, Frank E. J., Esser, Mark T., and Bont, Louis J.

Published
2020
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11. Nirsevimab binding-site conservation in respiratory syncytial virus fusion glycoprotein worldwide between 1956 and 2021: an analysis of observational study sequencing data

Author

Infectieziekten onderzoek1 (Bont), Infection & Immunity, MMB Research line 3a, CTI Bont, Child Health, Wilkins, Deidre, Langedijk, Annefleur C., Lebbink, Robert Jan, Morehouse, Christopher, Abram, Michael E., Ahani, Bahar, Aksyuk, Anastasia A., Baraldi, Eugenio, Brady, Tyler, Chen, Albert Tian, Chi, Hsin, Choi, Eun Hwa, Cohen, Robert, Danilenko, Daria M., Gopalakrishnan, Vancheswaran, Greenough, Anne, Heikkinen, Terho, Hosoya, Mitsuaki, Keller, Christian, Kelly, Elizabeth J., Kragten-Tabatabaie, Leyla, Martinón-Torres, Federico, de Los Santos, Abiel Homero Mascareñas, Nunes, Marta C., Palomino, María Angélica, Papenburg, Jesse, Pernica, Jeffrey M., Richmond, Peter, Stein, Renato T., Tuffy, Kevin M., Verwey, Charl, Esser, Mark T., Tabor, David E., Bont, Louis J., Clement, Pascale, Gupta, Atul, Hashimoto, Koichi, Komissarova, Kseniya, Laubscher, Matt, Lumertz, Magali, Priante, Elena, Rivero-Calle, Irene, Wadia, Ushma, Yun, Ki Wook, Infectieziekten onderzoek1 (Bont), Infection & Immunity, MMB Research line 3a, CTI Bont, Child Health, Wilkins, Deidre, Langedijk, Annefleur C., Lebbink, Robert Jan, Morehouse, Christopher, Abram, Michael E., Ahani, Bahar, Aksyuk, Anastasia A., Baraldi, Eugenio, Brady, Tyler, Chen, Albert Tian, Chi, Hsin, Choi, Eun Hwa, Cohen, Robert, Danilenko, Daria M., Gopalakrishnan, Vancheswaran, Greenough, Anne, Heikkinen, Terho, Hosoya, Mitsuaki, Keller, Christian, Kelly, Elizabeth J., Kragten-Tabatabaie, Leyla, Martinón-Torres, Federico, de Los Santos, Abiel Homero Mascareñas, Nunes, Marta C., Palomino, María Angélica, Papenburg, Jesse, Pernica, Jeffrey M., Richmond, Peter, Stein, Renato T., Tuffy, Kevin M., Verwey, Charl, Esser, Mark T., Tabor, David E., Bont, Louis J., Clement, Pascale, Gupta, Atul, Hashimoto, Koichi, Komissarova, Kseniya, Laubscher, Matt, Lumertz, Magali, Priante, Elena, Rivero-Calle, Irene, Wadia, Ushma, and Yun, Ki Wook

Published
2023

12. Respiratory syncytial virus prevention within reach: the vaccine and monoclonal antibody landscape

Author

Infectieziekten onderzoek1 (Bont), Infection & Immunity, Infectieziekten onderzoek2 (Wildenbeest), Infectieziekten patientenzorg, Child Health, CTI Bont, Mazur, Natalie I, Terstappen, Jonne, Baral, Ranju, Bardají, Azucena, Beutels, Philippe, Buchholz, Ursula J, Cohen, Cheryl, Crowe, James E, Cutland, Clare L, Eckert, Linda, Feikin, Daniel, Fitzpatrick, Tiffany, Fong, Youyi, Graham, Barney S, Heikkinen, Terho, Higgins, Deborah, Hirve, Siddhivinayak, Klugman, Keith P, Kragten-Tabatabaie, Leyla, Lemey, Philippe, Libster, Romina, Löwensteyn, Yvette, Mejias, Asuncion, Munoz, Flor M, Munywoki, Patrick K, Mwananyanda, Lawrence, Nair, Harish, Nunes, Marta C, Ramilo, Octavio, Richmond, Peter, Ruckwardt, Tracy J, Sande, Charles, Srikantiah, Padmini, Thacker, Naveen, Waldstein, Kody A, Weinberger, Dan, Wildenbeest, Joanne, Wiseman, Dexter, Zar, Heather J, Zambon, Maria, Bont, Louis, Infectieziekten onderzoek1 (Bont), Infection & Immunity, Infectieziekten onderzoek2 (Wildenbeest), Infectieziekten patientenzorg, Child Health, CTI Bont, Mazur, Natalie I, Terstappen, Jonne, Baral, Ranju, Bardají, Azucena, Beutels, Philippe, Buchholz, Ursula J, Cohen, Cheryl, Crowe, James E, Cutland, Clare L, Eckert, Linda, Feikin, Daniel, Fitzpatrick, Tiffany, Fong, Youyi, Graham, Barney S, Heikkinen, Terho, Higgins, Deborah, Hirve, Siddhivinayak, Klugman, Keith P, Kragten-Tabatabaie, Leyla, Lemey, Philippe, Libster, Romina, Löwensteyn, Yvette, Mejias, Asuncion, Munoz, Flor M, Munywoki, Patrick K, Mwananyanda, Lawrence, Nair, Harish, Nunes, Marta C, Ramilo, Octavio, Richmond, Peter, Ruckwardt, Tracy J, Sande, Charles, Srikantiah, Padmini, Thacker, Naveen, Waldstein, Kody A, Weinberger, Dan, Wildenbeest, Joanne, Wiseman, Dexter, Zar, Heather J, Zambon, Maria, and Bont, Louis

Published
2023

13. Nirsevimab binding-site conservation in respiratory syncytial virus fusion glycoprotein worldwide between 1956 and 2021: an analysis of observational study sequencing data

Author

Wilkins, Deidre, primary, Langedijk, Annefleur C, additional, Lebbink, Robert Jan, additional, Morehouse, Christopher, additional, Abram, Michael E, additional, Ahani, Bahar, additional, Aksyuk, Anastasia A, additional, Baraldi, Eugenio, additional, Brady, Tyler, additional, Chen, Albert Tian, additional, Chi, Hsin, additional, Choi, Eun Hwa, additional, Cohen, Robert, additional, Danilenko, Daria M, additional, Gopalakrishnan, Vancheswaran, additional, Greenough, Anne, additional, Heikkinen, Terho, additional, Hosoya, Mitsuaki, additional, Keller, Christian, additional, Kelly, Elizabeth J, additional, Kragten-Tabatabaie, Leyla, additional, Martinón-Torres, Federico, additional, de Los Santos, Abiel Homero Mascareñas, additional, Nunes, Marta C, additional, Palomino, María Angélica, additional, Papenburg, Jesse, additional, Pernica, Jeffrey M, additional, Richmond, Peter, additional, Stein, Renato T, additional, Tuffy, Kevin M, additional, Verwey, Charl, additional, Esser, Mark T, additional, Tabor, David E, additional, Bont, Louis J, additional, Clement, Pascale, additional, Gupta, Atul, additional, Hashimoto, Koichi, additional, Komissarova, Kseniya, additional, Laubscher, Matt, additional, Lumertz, Magali, additional, Priante, Elena, additional, Rivero-Calle, Irene, additional, Wadia, Ushma, additional, and Yun, Ki Wook, additional

Published
2023
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15. International changes in respiratory syncytial virus (RSV) epidemiology during the COVID-19 pandemic: Association with school closures

Author

CTM & Statistical consultation, CTI Bont, Infectieziekten onderzoek1 (Bont), Child Health, Infection & Immunity, Infectieziekten onderzoek2 (Wildenbeest), Infectieziekten patientenzorg, Billard, Marie Noëlle, van de Ven, Peter M., Baraldi, Bianca, Kragten-Tabatabaie, Leyla, Bont, Louis J., Wildenbeest, Joanne G., CTM & Statistical consultation, CTI Bont, Infectieziekten onderzoek1 (Bont), Child Health, Infection & Immunity, Infectieziekten onderzoek2 (Wildenbeest), Infectieziekten patientenzorg, Billard, Marie Noëlle, van de Ven, Peter M., Baraldi, Bianca, Kragten-Tabatabaie, Leyla, Bont, Louis J., and Wildenbeest, Joanne G.

Published
2022

17. Insights into therapeutic products, preclinical research models, and clinical trials in cardiac regenerative and reparative medicine:where are we now and the way ahead. Current opinion paper of the ESC Working Group on Cardiovascular Regenerative and Reparative Medicine

Author

Grigorian-Shamagian, Lilian, Sanz-Ruiz, Ricardo, Climent, Andreu, Badimon, Lina, Barile, Lucio, Bolli, Roberto, Chamuleau, Steven, Grobbee, Diederick E., Janssens, Stefan, Kastrup, Jens, Kragten-Tabatabaie, Leyla, Madonna, Rosalinda, Mathur, Anthony, Menasche, Philippe, Pompilio, Giulio, Prosper, Felipe, Sena, Emily, Smart, Nicola, Zimmermann, Wolfgram-Hubertus, Fernandez-Aviles, Francisco, Grigorian-Shamagian, Lilian, Sanz-Ruiz, Ricardo, Climent, Andreu, Badimon, Lina, Barile, Lucio, Bolli, Roberto, Chamuleau, Steven, Grobbee, Diederick E., Janssens, Stefan, Kastrup, Jens, Kragten-Tabatabaie, Leyla, Madonna, Rosalinda, Mathur, Anthony, Menasche, Philippe, Pompilio, Giulio, Prosper, Felipe, Sena, Emily, Smart, Nicola, Zimmermann, Wolfgram-Hubertus, and Fernandez-Aviles, Francisco

Abstract

Great expectations have been set around the clinical potential of regenerative and reparative medicine in the treatment of cardiovascular diseases [i.e. in particular, heart failure (HF)]. Initial excitement, spurred by encouraging preclinical data, resulted in a rapid translation into clinical research. The sobering outcome of the resulting clinical trials suggests that preclinical testing may have been insufficient to predict clinical outcome. A number of barriers for clinical translation include the inherent variability of the biological products and difficulties to develop potency and quality assays, insufficient rigour of the preclinical research and reproducibility of the results, manufacturing challenges, and scientific irregularities reported in the last years. The failure to achieve clinical success led to an increased scrutiny and scepticism as to the clinical readiness of stem cells and gene therapy products among clinicians, industry stakeholders, and funding bodies. The present impasse has attracted the attention of some of the most active research groups in the field, which were then summoned to analyse the position of the field and tasked to develop a strategy, to re-visit the undoubtedly promising future of cardiovascular regenerative and reparative medicine, based on lessons learned over the past two decades. During the scientific retreat of the ESC Working Group on Cardiovascular Regenerative and Reparative Medicine (CARE) in November 2018, the most relevant and timely research aspects in regenerative and/or reparative medicine were presented and critically discussed, with the aim to lay out a strategy for the future development of the field. We report herein the main ideas and conclusions of that meeting.

Published
2021

18. Proposal for Human Respiratory Syncytial Virus Nomenclature below the Species Level

Author

CTI Bont, Infectieziekten onderzoek1 (Bont), Child Health, Infection & Immunity, Salimi, Vahid, Viegas, Mariana, Trento, Alfonsina, Agoti, Charles N, Anderson, Larry J, Avadhanula, Vasanthi, Bahl, Justin, Bont, Louis, Brister, J Rodney, Cane, Patricia A, Galiano, Mónica, Graham, Barney S, Hatcher, Eneida L, Hellferscee, Orienka, Henke, David M, Hirve, Siddhivinayak, Jackson, Sandra, Keyaerts, Els, Kragten-Tabatabaie, Leyla, Lindstrom, Stephen, Nauwelaers, Inne, Nokes, D James, Openshaw, Peter J, Peret, Teresa C, Piedra, Pedro A, Ramaekers, Kaat, Rector, Annabel, Trovão, Nídia Sequeira, von Gottberg, Anne, Zambon, Maria, Zhang, Wenqing, Williams, Thomas C, Barr, Ian G, Buchholz, Ursula J, CTI Bont, Infectieziekten onderzoek1 (Bont), Child Health, Infection & Immunity, Salimi, Vahid, Viegas, Mariana, Trento, Alfonsina, Agoti, Charles N, Anderson, Larry J, Avadhanula, Vasanthi, Bahl, Justin, Bont, Louis, Brister, J Rodney, Cane, Patricia A, Galiano, Mónica, Graham, Barney S, Hatcher, Eneida L, Hellferscee, Orienka, Henke, David M, Hirve, Siddhivinayak, Jackson, Sandra, Keyaerts, Els, Kragten-Tabatabaie, Leyla, Lindstrom, Stephen, Nauwelaers, Inne, Nokes, D James, Openshaw, Peter J, Peret, Teresa C, Piedra, Pedro A, Ramaekers, Kaat, Rector, Annabel, Trovão, Nídia Sequeira, von Gottberg, Anne, Zambon, Maria, Zhang, Wenqing, Williams, Thomas C, Barr, Ian G, and Buchholz, Ursula J

Published
2021

19. Insights into therapeutic products, preclinical research models, and clinical trials in cardiac regenerative and reparative medicine: where are we now and the way ahead. Current opinion paper of the ESC Working Group on Cardiovascular Regenerative and Reparative Medicine

Author

Global Health, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Grigorian-Shamagian, Lilian, Sanz-Ruiz, Ricardo, Climent, Andreu, Badimon, Lina, Barile, Lucio, Bolli, Roberto, Chamuleau, Steven, Grobbee, Diederick E, Janssens, Stefan, Kastrup, Jens, Kragten-Tabatabaie, Leyla, Madonna, Rosalinda, Mathur, Anthony, Menasché, Philippe, Pompilio, Giulio, Prosper, Felipe, Sena, Emily, Smart, Nicola, Zimmermann, Wolfgram-Hubertus, Fernández-Avilés, Francisco, Global Health, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Grigorian-Shamagian, Lilian, Sanz-Ruiz, Ricardo, Climent, Andreu, Badimon, Lina, Barile, Lucio, Bolli, Roberto, Chamuleau, Steven, Grobbee, Diederick E, Janssens, Stefan, Kastrup, Jens, Kragten-Tabatabaie, Leyla, Madonna, Rosalinda, Mathur, Anthony, Menasché, Philippe, Pompilio, Giulio, Prosper, Felipe, Sena, Emily, Smart, Nicola, Zimmermann, Wolfgram-Hubertus, and Fernández-Avilés, Francisco

Published
2021

20. Global Molecular Epidemiology of Respiratory Syncytial Virus from the 2017-2018 INFORM-RSV Study

Author

Infectieziekten onderzoek1 (Bont), MMB Research line 1, MMB Research line 3a, Infection & Immunity, Facilitair team Zeist, CTI Bont, Infectiezieken, Child Health, Intensive care patientenzorg, Tabor, David E, Fernandes, Fiona, Langedijk, Annefleur C, Wilkins, Deidre, Lebbink, Robert Jan, Tovchigrechko, Andrey, Ruzin, Alexey, Kragten-Tabatabaie, Leyla, Jin, Hong, Esser, Mark T, Bont, Louis J, Abram, Michael E, INFORM-RSV Study Group, Infectieziekten onderzoek1 (Bont), MMB Research line 1, MMB Research line 3a, Infection & Immunity, Facilitair team Zeist, CTI Bont, Infectiezieken, Child Health, Intensive care patientenzorg, Tabor, David E, Fernandes, Fiona, Langedijk, Annefleur C, Wilkins, Deidre, Lebbink, Robert Jan, Tovchigrechko, Andrey, Ruzin, Alexey, Kragten-Tabatabaie, Leyla, Jin, Hong, Esser, Mark T, Bont, Louis J, Abram, Michael E, and INFORM-RSV Study Group

Published
2021

21. Proposal for Human Respiratory Syncytial Virus Nomenclature below the Species Level

Author

Salimi, Vahid, primary, Viegas, Mariana, additional, Trento, Alfonsina, additional, Agoti, Charles N., additional, Anderson, Larry J., additional, Avadhanula, Vasanthi, additional, Bahl, Justin, additional, Bont, Louis, additional, Brister, J. Rodney, additional, Cane, Patricia A., additional, Galiano, Mónica, additional, Graham, Barney S., additional, Hatcher, Eneida L., additional, Hellferscee, Orienka, additional, Henke, David M., additional, Hirve, Siddhivinayak, additional, Jackson, Sandra, additional, Keyaerts, Els, additional, Kragten-Tabatabaie, Leyla, additional, Lindstrom, Stephen, additional, Nauwelaers, Inne, additional, Nokes, D. James, additional, Openshaw, Peter J., additional, Peret, Teresa C., additional, Piedra, Pedro A., additional, Ramaekers, Kaat, additional, Rector, Annabel, additional, Trovão, Nídia Sequeira, additional, von Gottberg, Anne, additional, Zambon, Maria, additional, Zhang, Wenqing, additional, Williams, Thomas C., additional, Barr, Ian G., additional, and Buchholz, Ursula J., additional

Published
2021
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22. Insights into therapeutic products, preclinical research models, and clinical trials in cardiac regenerative and reparative medicine: where are we now and the way ahead. Current opinion paper of the ESC Working Group on Cardiovascular Regenerative and Reparative Medicine

Author

Grigorian-Shamagian, Lilian, primary, Sanz-Ruiz, Ricardo, additional, Climent, Andreu, additional, Badimon, Lina, additional, Barile, Lucio, additional, Bolli, Roberto, additional, Chamuleau, Steven, additional, Grobbee, Diederick E, additional, Janssens, Stefan, additional, Kastrup, Jens, additional, Kragten-Tabatabaie, Leyla, additional, Madonna, Rosalinda, additional, Mathur, Anthony, additional, Menasché, Philippe, additional, Pompilio, Giulio, additional, Prosper, Felipe, additional, Sena, Emily, additional, Smart, Nicola, additional, Zimmermann, Wolfgram-Hubertus, additional, and Fernández-Avilés, Francisco, additional

Published
2020
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23. Additional file 1 of Global molecular diversity of RSV – the 'INFORM RSV' study

Author

Annefleur C. Langedijk, Lebbink, Robert Jan, Naaktgeboren, Christiana, Evers, Anouk, Viveen, Marco C., Greenough, Anne, Heikkinen, Terho, Stein, Renato T., Richmond, Peter, Martinón-Torres, Federico, Nunes, Marta, Hosoya, Mitsuaki, Keller, Christian, Bauck, Monika, Cohen, Robert, Papenburg, Jesse, Pernica, Jeffrey, Hennus, Marije P., Jin, Hong, Tabor, David E., Andrev Tovchigrechko, Ruzin, Alexey, Abram, Michael E., Wilkins, Deidre, Wildenbeest, Joanne G., Kragten-Tabatabaie, Leyla, Coenjaerts, Frank E. J., Esser, Mark T., and Bont, Louis J.

Abstract

Additional file 1: Table 1. Countries participating in the INFORM RSV study. 1Two sites are collecting 50 samples each.

Published
2020
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24. Global molecular diversity of RSV - the 'INFORM RSV' study

Author

Infectieziekten onderzoek1 (Bont), MMB Research line 3a, Infection & Immunity, Epi Methoden Team 1, MMB, Intensive care patientenzorg, DT Panda, Infectieziekten patientenzorg, CTI Bont, Infectiezieken, Child Health, Langedijk, Annefleur C, Lebbink, Robert Jan, Naaktgeboren, Christiana, Evers, Anouk, Viveen, Marco C, Greenough, Anne, Heikkinen, Terho, Stein, Renato T, Richmond, Peter, Martinón-Torres, Federico, Nunes, Marta, Hosoya, Mitsuaki, Keller, Christian, Bauck, Monika, Cohen, Robert, Papenburg, Jesse, Pernica, Jeffrey, Hennus, Marije P, Jin, Hong, Tabor, David E, Tovchigrechko, Andrev, Ruzin, Alexey, Abram, Michael E, Wilkins, Deidre, Wildenbeest, Joanne G, Kragten-Tabatabaie, Leyla, Coenjaerts, Frank E J, Esser, Mark T, Bont, Louis J, Infectieziekten onderzoek1 (Bont), MMB Research line 3a, Infection & Immunity, Epi Methoden Team 1, MMB, Intensive care patientenzorg, DT Panda, Infectieziekten patientenzorg, CTI Bont, Infectiezieken, Child Health, Langedijk, Annefleur C, Lebbink, Robert Jan, Naaktgeboren, Christiana, Evers, Anouk, Viveen, Marco C, Greenough, Anne, Heikkinen, Terho, Stein, Renato T, Richmond, Peter, Martinón-Torres, Federico, Nunes, Marta, Hosoya, Mitsuaki, Keller, Christian, Bauck, Monika, Cohen, Robert, Papenburg, Jesse, Pernica, Jeffrey, Hennus, Marije P, Jin, Hong, Tabor, David E, Tovchigrechko, Andrev, Ruzin, Alexey, Abram, Michael E, Wilkins, Deidre, Wildenbeest, Joanne G, Kragten-Tabatabaie, Leyla, Coenjaerts, Frank E J, Esser, Mark T, and Bont, Louis J

Published
2020

25. Insights into therapeutic products, preclinical research models, and clinical trials in cardiac regenerative and reparative medicine: where are we now and the way ahead. Current opinion paper of the ESC Working Group on Cardiovascular Regenerative and Reparative Medicine

Author

Grigorian-Shamagian, Lilian, Sanz-Ruiz, Ricardo, Climent, Andreu, Badimon, Lina, Barile, Lucio, Bolli, Roberto, Chamuleau, Steven, Grobbee, Diederick E, Janssens, Stefan, Kastrup, Jens, Kragten-Tabatabaie, Leyla, Madonna, Rosalinda, Mathur, Anthony, Menasché, Philippe, Pompilio, Giulio, Prosper, Felipe, Sena, Emily, Smart, Nicola, Zimmermann, Wolfgram-Hubertus, and Fernández-Avilés, Francisco

Subjects
REGENERATIVE medicine, MEDICAL research, CLINICAL trials, ANIMAL models in research, MEDICAL personnel
Abstract

Great expectations have been set around the clinical potential of regenerative and reparative medicine in the treatment of cardiovascular diseases [i.e. in particular, heart failure (HF)]. Initial excitement, spurred by encouraging preclinical data, resulted in a rapid translation into clinical research. The sobering outcome of the resulting clinical trials suggests that preclinical testing may have been insufficient to predict clinical outcome. A number of barriers for clinical translation include the inherent variability of the biological products and difficulties to develop potency and quality assays, insufficient rigour of the preclinical research and reproducibility of the results, manufacturing challenges, and scientific irregularities reported in the last years. The failure to achieve clinical success led to an increased scrutiny and scepticism as to the clinical readiness of stem cells and gene therapy products among clinicians, industry stakeholders, and funding bodies. The present impasse has attracted the attention of some of the most active research groups in the field, which were then summoned to analyse the position of the field and tasked to develop a strategy, to re-visit the undoubtedly promising future of cardiovascular regenerative and reparative medicine, based on lessons learned over the past two decades. During the scientific retreat of the ESC Working Group on Cardiovascular Regenerative and Reparative Medicine (CARE) in November 2018, the most relevant and timely research aspects in regenerative and/or reparative medicine were presented and critically discussed, with the aim to lay out a strategy for the future development of the field. We report herein the main ideas and conclusions of that meeting. [ABSTRACT FROM AUTHOR]

Published
2021
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26. The respiratory syncytial virus vaccine landscape : lessons from the graveyard and promising candidates

Author

Mazur, Natalie I., Higgins, Deborah, Nunes, Marta C., Melero, José A., Langedijk, Annefleur C., Horsley, Nicole, Buchholz, Ursula J., Openshaw, Peter J., McLellan, Jason S., Englund, Janet A., Mejias, Asuncion, Karron, Ruth A., Simões, Eric AF, Knezevic, Ivana, Ramilo, Octavio, Piedra, Pedro A., Chu, Helen Y., Falsey, Ann R., Nair, Harish, Kragten-Tabatabaie, Leyla, Greenough, Anne, Baraldi, Eugenio, Papadopoulos, Nikolaos G., Vekemans, Johan, Polack, Fernando P., Powell, Mair, Satav, Ashish, Walsh, Edward E., Stein, Renato T., Graham, Barney S., Bont, Louis J., Respiratory Syncytial Virus Network (ReSViNET) Foundation, Mazur, Natalie I., Higgins, Deborah, Nunes, Marta C., Melero, José A., Langedijk, Annefleur C., Horsley, Nicole, Buchholz, Ursula J., Openshaw, Peter J., McLellan, Jason S., Englund, Janet A., Mejias, Asuncion, Karron, Ruth A., Simões, Eric AF, Knezevic, Ivana, Ramilo, Octavio, Piedra, Pedro A., Chu, Helen Y., Falsey, Ann R., Nair, Harish, Kragten-Tabatabaie, Leyla, Greenough, Anne, Baraldi, Eugenio, Papadopoulos, Nikolaos G., Vekemans, Johan, Polack, Fernando P., Powell, Mair, Satav, Ashish, Walsh, Edward E., Stein, Renato T., Graham, Barney S., Bont, Louis J., and Respiratory Syncytial Virus Network (ReSViNET) Foundation

Published
2018

27. The respiratory syncytial virus vaccine landscape: lessons from the graveyard and promising candidates

Author

Infectieziekten onderzoek1 (Bont), Infectiezieken, CTI Bont, Child Health, Infection & Immunity, Mazur, Natalie I., Higgins, Deborah, Nunes, Marta C., Melero, José A., Langedijk, Annefleur C., Horsley, Nicole, Buchholz, Ursula J., Openshaw, Peter J., McLellan, Jason S., Englund, Janet A., Mejias, Asuncion, Karron, Ruth A., Simões, Eric AF, Knezevic, Ivana, Ramilo, Octavio, Piedra, Pedro A., Chu, Helen Y., Falsey, Ann R., Nair, Harish, Kragten-Tabatabaie, Leyla, Greenough, Anne, Baraldi, Eugenio, Papadopoulos, Nikolaos G., Vekemans, Johan, Polack, Fernando P., Powell, Mair, Satav, Ashish, Walsh, Edward E., Stein, Renato T., Graham, Barney S., Bont, Louis J., Respiratory Syncytial Virus Network (ReSViNET) Foundation, Infectieziekten onderzoek1 (Bont), Infectiezieken, CTI Bont, Child Health, Infection & Immunity, Mazur, Natalie I., Higgins, Deborah, Nunes, Marta C., Melero, José A., Langedijk, Annefleur C., Horsley, Nicole, Buchholz, Ursula J., Openshaw, Peter J., McLellan, Jason S., Englund, Janet A., Mejias, Asuncion, Karron, Ruth A., Simões, Eric AF, Knezevic, Ivana, Ramilo, Octavio, Piedra, Pedro A., Chu, Helen Y., Falsey, Ann R., Nair, Harish, Kragten-Tabatabaie, Leyla, Greenough, Anne, Baraldi, Eugenio, Papadopoulos, Nikolaos G., Vekemans, Johan, Polack, Fernando P., Powell, Mair, Satav, Ashish, Walsh, Edward E., Stein, Renato T., Graham, Barney S., Bont, Louis J., and Respiratory Syncytial Virus Network (ReSViNET) Foundation

Published
2018

28. Respiratory syncytial virus seasonality: A global overview

Author

CTI Bont, Child Health, Infection & Immunity, Obando-Pacheco, Pablo, Justicia-Grande, Antonio José, Rivero-Calle, Irene, Rodríguez-Tenreiro, Carmen, Sly, Peter, Ramilo, Octavio, Mejías, Asunción, Baraldi, Eugenio, Papadopoulos, Nikolaos G., Nair, Harish, Nunes, Marta C., Kragten-Tabatabaie, Leyla, Heikkinen, Terho, Greenough, Anne, Stein, Renato T., Manzoni, Paolo, Bont, Louis, Martinón-Torres, Federico, CTI Bont, Child Health, Infection & Immunity, Obando-Pacheco, Pablo, Justicia-Grande, Antonio José, Rivero-Calle, Irene, Rodríguez-Tenreiro, Carmen, Sly, Peter, Ramilo, Octavio, Mejías, Asunción, Baraldi, Eugenio, Papadopoulos, Nikolaos G., Nair, Harish, Nunes, Marta C., Kragten-Tabatabaie, Leyla, Heikkinen, Terho, Greenough, Anne, Stein, Renato T., Manzoni, Paolo, Bont, Louis, and Martinón-Torres, Federico

Published
2018

29. Meeting report : Harmonization of RSV therapeutics - from design to performance

Author

Nair, Harish, Ramilo, Octavio, Eichler, Irmgard, Pelfrene, Eric, Mejias, Asuncion, Polack, Fernando P., Pouwels, Koen B., Langley, Joanne M., Nunes, Marta, van der Maas, Nicoline, Kragten-Tabatabaie, Leyla, Baraldi, Eugenio, Heikkinen, Terho, Fauroux, Brigitte, Sharland, Mike, Park, Cyrus, Manzoni, Paolo, Papadopoulos, Nikolaos G., Martinón-Torres, Federico, Stein, Renato, Bont, Louis, Nair, Harish, Ramilo, Octavio, Eichler, Irmgard, Pelfrene, Eric, Mejias, Asuncion, Polack, Fernando P., Pouwels, Koen B., Langley, Joanne M., Nunes, Marta, van der Maas, Nicoline, Kragten-Tabatabaie, Leyla, Baraldi, Eugenio, Heikkinen, Terho, Fauroux, Brigitte, Sharland, Mike, Park, Cyrus, Manzoni, Paolo, Papadopoulos, Nikolaos G., Martinón-Torres, Federico, Stein, Renato, and Bont, Louis

Published
2016

30. Meeting report: Harmonization of RSV therapeutics - from design to performance

Author

UMC Utrecht, CTI Bont, Child Health, Infection & Immunity, Infectieziekten onderzoek1 (Bont), Nair, Harish, Ramilo, Octavio, Eichler, Irmgard, Pelfrene, Eric, Mejias, Asuncion, Polack, Fernando P., Pouwels, Koen B., Langley, Joanne M., Nunes, Marta, van der Maas, Nicoline, Kragten-Tabatabaie, Leyla, Baraldi, Eugenio, Heikkinen, Terho, Fauroux, Brigitte, Sharland, Mike, Park, Cyrus, Manzoni, Paolo, Papadopoulos, Nikolaos G., Martinón-Torres, Federico, Stein, Renato, Bont, Louis, UMC Utrecht, CTI Bont, Child Health, Infection & Immunity, Infectieziekten onderzoek1 (Bont), Nair, Harish, Ramilo, Octavio, Eichler, Irmgard, Pelfrene, Eric, Mejias, Asuncion, Polack, Fernando P., Pouwels, Koen B., Langley, Joanne M., Nunes, Marta, van der Maas, Nicoline, Kragten-Tabatabaie, Leyla, Baraldi, Eugenio, Heikkinen, Terho, Fauroux, Brigitte, Sharland, Mike, Park, Cyrus, Manzoni, Paolo, Papadopoulos, Nikolaos G., Martinón-Torres, Federico, Stein, Renato, and Bont, Louis

Published
2016

31. Global Molecular Epidemiology of Respiratory Syncytial Virus from the 2017-2018 INFORM-RSV Study

Author

Tabor, David E., Fernandes, Fiona, Langedijk, Annefleur C., Wilkins, Deidre, Lebbink, Robert Jan, Tovchigrechko, Andrey, Ruzin, Alexey, Kragten-Tabatabaie, Leyla, Jin, Hong, Esser, Mark T., Bont, Louis J., and Abram, Michael E.

Abstract

Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infection among infants and young children, resulting in annual epidemics worldwide. INFORM-RSV is a multiyear clinical study designed to describe the global molecular epidemiology of RSV in children under 5 years of age by monitoring temporal and geographical evolution of current circulating RSV strains, F protein antigenic sites, and their relationships with clinical features of RSV disease. During the pilot season (2017–2018), 410 RSV G-F gene sequences were obtained from 476 RSV-positive nasal samples collected from 8 countries (United Kingdom, Spain, The Netherlands, Finland, Japan, Brazil, South Africa, and Australia).

Published
2020
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