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Your search keyword '"Kraitchman, Dara L"' showing total 404 results
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404 results on '"Kraitchman, Dara L"'

12. Thermal Characterization and Preclinical Feasibility Verification of an Accessible, Carbon Dioxide-Based Cryotherapy System.

Author

Hu, Yixin, Gordon, Naomi, Ogg, Katherine, Kraitchman, Dara L., Durr, Nicholas J., and Surtees, Bailey

Subjects
COLD therapy, RESOURCE-limited settings, BREAST cancer, CARBON dioxide, BOILING-points
Abstract

To investigate the potential of an affordable cryotherapy device for the accessible treatment of breast cancer, the performance of a novel carbon dioxide-based device was evaluated through both benchtop testing and an in vivo canine model. This novel device was quantitatively compared to a commercial device that utilizes argon gas as the cryogen. The thermal behavior of each device was characterized through calorimetry and by measuring the temperature profiles of iceballs generated in tissue phantoms. A 45 min treatment in a tissue phantom from the carbon dioxide device produced a 1.67 ± 0.06 cm diameter lethal isotherm that was equivalent to a 7 min treatment from the commercial argon-based device, which produced a 1.53 ± 0.15 cm diameter lethal isotherm. An in vivo treatment was performed with the carbon dioxide-based device in one spontaneously occurring canine mammary mass with two standard 10 min freezes. Following cryotherapy, this mass was surgically resected and analyzed for necrosis margins via histopathology. The histopathology margin of necrosis from the in vivo treatment with the carbon dioxide device at 14 days post-cryoablation was 1.57 cm. While carbon dioxide gas has historically been considered an impractical cryogen due to its low working pressure and high boiling point, this study shows that carbon dioxide-based cryotherapy may be equivalent to conventional argon-based cryotherapy in size of the ablation zone in a standard treatment time. The feasibility of the carbon dioxide device demonstrated in this study is an important step towards bringing accessible breast cancer treatment to women in low-resource settings. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Validation of a Temperature-Feedback Controlled Automated Magnetic Hyperthermia Therapy Device

Author

Sharma, Anirudh, primary, Jangam, Avesh, additional, Shen, Julian Low Yung, additional, Ahmad, Aiman, additional, Arepally, Nageshwar, additional, Rodriguez, Benjamin, additional, Borrello, Joseph, additional, Bouras, Alexandros, additional, Kleinberg, Lawrence, additional, Ding, Kai, additional, Hadjipanayis, Constantinos, additional, Kraitchman, Dara L., additional, Ivkov, Robert, additional, and Attaluri, Anilchandra, additional

Published
2023
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21. Spin- and Gradient-Echo Imaging

Author

Kraitchman, Dara L., Baert, A. L., editor, Sartor, K., editor, Filippi, Massimo, editor, De Stefano, Nicola, editor, Dousset, Vincent, editor, and McGowan, Joseph C., editor

Published
2005
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22. Association Between Gut Hormones and Weight Change After Bariatric Arterial Embolization: Results from the BEAT Obesity Trial

Author

Latif, Muhammad A., primary, Tunacao, Jessa M., additional, Fu, Yingli, additional, Moran, Timothy H., additional, Yenokyan, Gayane, additional, Fischman, Aaron M., additional, Cheskin, Lawrence J., additional, Holly, Brian P., additional, Hong, Kelvin, additional, Shin, Eun J., additional, Steele, Kimberley E., additional, Kraitchman, Dara L., additional, Arepally, Aravind, additional, and Weiss, Clifford R., additional

Published
2022
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32. Interventional Radiology Obesity Therapeutics: Proceedings from the Society of Interventional Radiology Foundation Research Consensus Panel

Author

Yuan, Frank, primary, Latif, Muhammad A., additional, Shafaat, Omid, additional, Prologo, J. David, additional, Hill, James O., additional, Gudzune, Kimberly A., additional, Marrone, April K., additional, Kraitchman, Dara L., additional, Rogers, Ann M., additional, Khaitan, Leena, additional, Oklu, Rahmi, additional, Pereira, Keith, additional, Steele, Kimberley, additional, White, Sarah B., additional, and Weiss, Clifford R., additional

Published
2021
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37. Magnetic resonance-guided, real-time targeted delivery and imaging of magnetocapsules immunoprotecting pancreatic islet cells

Author

Barnett, Brad P., Arepally, Aravind, Karmarkar, Parag V., Qian, Di, Gilson, Wesley D., Walczak, Piotr, Howland, Valerie, Lawler, Leo, Lauzon, Cal, Stuber, Matthias, Kraitchman, Dara L., and Bulte, Jeff W M

Abstract

Author(s): Brad P Barnett [1, 2]; Aravind Arepally (corresponding author) [1, 4]; Parag V Karmarkar [1]; Di Qian [1]; Wesley D Gilson [1]; Piotr Walczak [1, 2]; Valerie Howland [1]; [...]

Published
2007
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43. Late systolic onset of regional LV relaxation demonstrated in three-dimensional space by MRI tissue tagging

Author

Rosen, Boaz D., Gerber, Bernhard L., Edvardsen, Thor, Castillo, Ernesto, Amado, Luciano C., Nasir, Khurram, Kraitchman, Dara L., Osman, Nael F., Bluemke, David A., and Lima, Joao A.C.

Subjects
Cardiology -- Research, Biological sciences
Abstract

Late systolic onset of regional LV relaxation demonstrated in three-dimensional space by MRI tissue tagging. Am J Physiol Heart Circ Physiol 287: H1740-H1746, 2004. First published June 17, 2004; 10.1152/ajpheart.00080.2004.--Left ventricular (LV) relaxation entails myocardial deformation that induces LV filling. Yet, the precise mechanisms of the earliest changes in tissue properties that characterize myocardial relaxation remain incompletely understood. Ten healthy volunteers (seven males), 25-43 yr, underwent tagged and cine MRI with high temporal resolution (25-35 ms). Normal strains including radial ([E.sub.rr]), circumferential ([E.sub.cc]), and longitudinal ([E.sub.11]) strains, shear strains including [E.sub.c1] (circumferential-longitudinal), [E.sub.cr] (circumferential-radial), and [E.sub.r1] (radial-longitudinal), and principal strains ([E.sub.1], [E.sub.2], and [E.sub.3]) were calculated using a displacement field-fitting method. Temporal changes in angular strains indicative of shear and torsion release and normal strains were studied during late systole and early relaxation. The onset of individual relaxation strains was heterogeneous relative to LV filling. Shear strains ([E.sub.cr], [E.sub.r1], and [E.sub.c1]) and radial thinning were first to develop. Times of onset of [E.sub.cr], [E.sub.r1], [E.sub.c1], and [E.sub.rr] occurred 108, 93, 67, and 73 ms before aortic valve closure, respectively. [E.sub.11], [E.sub.cc], and LV volume change commenced significantly later after the onset of diastolic shear strains and radial thinning. The onset of [E.sub.cc], [E.sub.11], and LV volume change was noted 38 ms before aortic valve closure (P [less than or equal to] 0.05 relative to the onset of shear strains and [E.sub.rr]). Myocardial relaxation is characterized by a three-dimensional unfolding deformation that includes release of torsion, shear, and radial thinning beginning before aortic valve closure. This unfolding pattern precedes longitudinal and circumferential elongation and may facilitate early diastolic filling. diastole; magnetic resonance imaging; ventricle; strain; shear

Published
2004

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