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3. Crisis and the Arts: The History of Dada. Hall. 1996-2002. Vol II: Dada Zurich: A Clown's Game from Nothing by <given-names>Stephen C.</given-names> <surname>Foster</surname>, <given-names>Brigitte</given-names> <surname>Pichon</surname>, <given-names>Karl</given-names> <surname>Riha</surname>Crisis and the Arts: The History of Dada. Vol. III: Dada Cologne Hanover by <given-names>Charlotte</given-names> <surname>Stokes</surname>, <given-names>Stephen C.</given-names> <surname>Foster</surname> (review)

Author

Kramer, Andreas

Published
2022

10. Prognostic value of near-infrared spectroscopy regional oxygen saturation and cerebrovascular reactivity index in acute traumatic neural injury: a CAnadian High-Resolution Traumatic Brain Injury (CAHR-TBI) Cohort Study

Author

Gomez, Alwyn, Froese, Logan, Griesdale, Donald, Thelin, Eric P., Raj, Rahul, van Iperenburg, Levi, Tas, Jeanette, Aries, Marcel, Stein, Kevin Y., Gallagher, Clare, Bernard, Francis, Kramer, Andreas H., and Zeiler, Frederick A.

Published
2024
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19. A brain-based definition of death and criteria for its determination after arrest of circulation or neurologic function in Canada: a 2023 clinical practice guideline

Author

Shemie, Sam D., Wilson, Lindsay C., Hornby, Laura, Basmaji, John, Baker, Andrew J., Bensimon, Cécile M., Chandler, Jennifer A., Chassé, Michaël, Dawson, Rosanne, Dhanani, Sonny, Mooney, Owen T., Sarti, Aimee J., Simpson, Christy, Teitelbaum, Jeanne, Torrance, Sylvia, Boyd, J. Gordon, Brennan, Joanne, Brewster, Heather, Carignan, Robert, Dawe, Kirk J., Doig, Christopher J., Elliott-Pohl, Kennedy, Gofton, Teneille E., Hartwick, Michael, Healey, Andrew, Honarmand, Kimia, Hornby, Karen, Isac, George, Kanji, Aly, Kawchuk, Joann, Klowak, Jennifer A., Kramer, Andreas H., Kromm, Julie, LeBlanc, Allana E., Lee-Ameduri, Katarina, Lee, Laurie A., Leeies, Murdoch, Lewis, Ariane, Manara, Alex, Matheson, Shauna, McKinnon, Nicole K. A., Murphy, Nicholas, Briard, Joel Neves, Pope, Thaddeus M., Sekhon, Mypinder S., Shanker, Jai Jai S., Singh, Gurmeet, Singh, Jeffrey, Slessarev, Marat, Soliman, Karim, Sutherland, Stephanie, Weiss, Matthew J., Shaul, Randi Zlotnik, Zuckier, Lionel S., Zorko, David J., and Rochwerg, Bram

Published
2023
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20. Death determination by neurologic criteria—what do families understand?

Author

Sarti, Aimee J., Sutherland, Stephanie, Meade, Maureen, Hornby, Laura, Wilson, Lindsay C., Landriault, Angele, Vanderspank-Wright, Brandi, Valiani, Sabira, Keenan, Sean, Weiss, Matthew J., Werestiuk, Kim, Beed, Stephen, Kramer, Andreas H., Kawchuk, Joann, Cardinal, Pierre, Dhanani, Sonny, Lotherington, Ken, Pagliarello, Giuseppe, Chassé, Michaël, Gatien, Mary, Parsons, Kim, Chandler, Jennifer A., Nickerson, Peter, and Shemie, Sam D.

Published
2023
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24. Correction: Death determination by neurologic criteria—what do families understand?

Author

Sarti, Aimee J., Sutherland, Stephanie, Meade, Maureen, Hornby, Laura, Wilson, Lindsay C., Landriault, Angele, Vanderspank-Wright, Brandi, Valiani, Sabira, Keenan, Sean, Weiss, Matthew J., Werestiuk, Kim, Beed, Stephen, Kramer, Andreas H., Kawchuk, Joann, Cardinal, Pierre, Dhanani, Sonny, Lotherington, Ken, Pagliarello, Giuseppe, Chassé, Michaël, Gatien, Mary, Parsons, Kim, Chandler, Jennifer A., Nickerson, Peter, and Shemie, Sam D.

Published
2023
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25. Neuroprognostication in the Post Cardiac Arrest Patient: A Canadian Cardiovascular Society Position Statement

Author

Fordyce, Christopher B., Kramer, Andreas H., Ainsworth, Craig, Christenson, Jim, Hunter, Gary, Kromm, Julie, Lopez Soto, Carmen, Scales, Damon C., Sekhon, Mypinder, van Diepen, Sean, Dragoi, Laura, Josephson, Colin, Kutsogiannis, Jim, Le May, Michel R., Overgaard, Christopher B., Savard, Martin, Schnell, Gregory, Wong, Graham C., Belley-Côté, Emilie, Fantaneanu, Tadeu A., Granger, Christopher B., Luk, Adriana, Mathew, Rebecca, McCredie, Victoria, Murphy, Laurel, and Teitelbaum, Jeanne

Published
2023
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26. Premortem anticoagulation timing and dose in donation after circulatory death: multicentre study of associations with graft function

Author

Kramer, Andreas H., Holliday, Kerry, Keenan, Sean, Isac, George, Kutsogiannis, Demetrius J., Kneteman, Norman M., Kim, Peter, Robertson, Adrian, Nickerson, Peter W., and Tibbles, Lee Anne

Subjects
Heparin -- Dosage and administration, Transplantation of organs, tissues, etc. -- Patient outcomes, Organ donors -- Drug therapy -- Physiological aspects, Donation of organs, tissues, etc. -- Methods, Death -- Physiological aspects, Health, Health care industry
Abstract

Background: In controlled donation after circulatory determination of death (DCD), it is common to administer premortem heparin to potential donors. This practice remains controversial because there is limited evidence for it and there is the possibility of inducing hemorrhage. To our knowledge, no previous studies have assessed the effects of heparin timing and dose on graft function. Methods: We performed a multicentre cohort study of consecutive DCD donors and the recipients of their organs. Anti coagulation administration was considered early if given near the time of withdrawal of life-sustaining measures and late if delayed until the onset of donor hypoxemia (oxygen saturation < 70%) or hypotension (systolic blood pressure < 60 mm Hg or mean blood pressure < 50 mm Hg). The anticoagulation dose was considered high if it was 300 units/kg or greater. Results: Donor anticoagulation data were available for 301 kidney, 75 liver and 46 lung recipients. Heparin was administered in 92% of cases and was most commonly withheld in donors with cerebrovascular causes of death (p = 0.01). Administration was late in 59% and the dose was low in 27%. Among kidney recipients, there were no significant differences in need for dialysis, glomerular filtration rate over the first year after transplantation or graft survival on the basis of whether or not the donor received heparin, the timing of heparin administration or the dose of heparin. Among liver recipients, alkaline phosphatase concentrations over the first year were significantly higher among recipients who received organs from donors to whom lower doses of heparin had been administered. Conclusion: Premortem heparin is widely used in DCD cases, but there is variability in timing and dose, which was not associated with kidney outcomes in this study. Donor anticoagulation may have a greater impact in preventing biliary complications following liver transplantation. Contexte : Dans les cas de don controle apres un diagnostic de deces cardiorespiratoire (DDC), il est courant d'administrer de l'heparine aux donneurs potentiels avant le deces. Cette pratique demeure controversee faute de donnees probantes a l'appui et par son risque de declencher une hemorragie. A notre connaissance, il n'existe aucune etude ayant evalue les effets de la dose d'heparine et du moment de son administration sur la fonction du greffon. Methodes : Une etude de cohorte multicentrique a ete realisee sur des donneurs decedes apres un DDC et sur ceux qui ont recu leurs organes. L'administration d'anticoagulants etait consideree comme hative si elle avait lieu peu avant le retrait des mesures de maintien de la vie et tardive si elle etait repoussee a la survenue de l'hypoxemie (saturation en oxygene inferieure a 70 %) ou de l'hypotension (tension arterielle systolique inferieure a 60 mm Hg ou tension arterielle moyenne inferieure a 50 mm Hg) chez le donneur. La dose d'anticoagulant etait consideree comme elevee si elle etait de 300 unites/kg ou plus. Resultats : Des donnees sur l'administration d'anticoagulants aux donneurs etaient disponibles pour les receveurs des organes suivants : rein (301), foie (75) et poumon (46). L'heparine a ete administree dans 92 % des cas; son administration a ete refusee le plus souvent aux donneurs dont le deces etait d'origine cerebrovasculaire (p = 0,01). L'administration a ete tardive dans 59 % des cas et la dose etait faible dans 27 % des cas. Pour les receveurs de rein, l'administration d'heparine au donneur, le moment de l'administration et la dose d'heparine n'ont entraine aucune difference significative dans le besoin de dialyse et le debit de filtration glomerulaire durant la premiere annee apres la transplantation. Quant aux receveurs de foie, les concentrations de phosphatase alcaline etaient significativement plus elevees durant la premiere annee chez ceux dont le donneur avait recu des doses d'heparine plus faibles. Conclusion : L'heparine est couramment administree avant le deces dans les cas de DDC, mais la dose et le moment d'administration varient, des variations qui n'ont pas ete associees aux resultats renaux dans cette etude. L'administration d'anticoagulants chez le donneur pourrait avoir une plus grande incidence dans la prevention des complications biliaires a la suite d'une transplantation de foie., The opportunity for organ donation is an important aspect of end-of-life care for some critically ill patients and their families. (1-3) Transplantation improves the survival of recipients, enhances their quality [...]

Published
2022
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29. 120 Outcome Related Thresholds of Near Infrared Spectroscopy Based Cerebrovascular Reactivity Metrics in Moderate Severe TBI: A Canadian High Resolution-TBI (CAHR-TBI) Cohort Study

Author

Gomez, Alwyn Titus, primary, Tas, Jeanette, additional, Aries, Marcel, additional, Griesdale, Donald, additional, Froese, Logan, additional, Thelin, Eric, additional, Raj, Rahul, additional, Gallagher, Clare Naomi, additional, Bernard, Francis, additional, Kramer, Andreas H., additional, and Zeiler, Frederick, additional

Published
2024
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31. The experiences of family members of deceased organ donors and suggestions to improve the donation process: a qualitative study

Author

Sarti, Aimee J., Sutherland, Stephanie, Meade, Maureen, Shemie, Sam, Landriault, Angele, Vanderspank-Wright, Brandi, Valiani, Sabira, Keenan, Sean, Weiss, Matthew J., Werestiuk, Kim, Kramer, Andreas H., Kawchuk, Joann, Beed, Stephen, Dhanani, Sonny, Pagliarello, Giuseppe, Chasse, Michael, Lotherington, Ken, Gatien, Mary, Parsons, Kim, Llm, Jennifer A. Chandler, Nickerson, Peter, and Cardinal, Pierre

Subjects
Organ donors -- Family, Family services -- Management -- Evaluation, Donation of organs, tissues, etc. -- Methods -- Public opinion, Company business management, Health
Abstract

Background: Decisions about organ donation are stressful for family members of potential organ donors. We sought to comprehensively explore the donation process from interviews conducted with family members of patients admitted to pediatric and adult intensive care units in Canada. Methods: We conducted a qualitative study using semistructured, in-depth interviews with 271 family members asked to make an organ donation decision. We recruited participants from all provinces with an organ donation organization (n = 10), and analyzed themes using a modified grounded theory approach. On the basis of these inter views, suggestions were made by researchers and family members on how to improve the process of organ donation. Results: We identified 3 main themes and 9 subthemes. Families need more comprehensive support around the time of donation, including having access to someone with shared experiences, support during specific moments as needed and better support during critical transitions (e.g., when the donor body goes to the operating room). The theme of better connection to recipient(s) included receiving information about the donation surgery (e.g., which organs were recovered), establishing connection with recipients (e.g., via social networks or letters) and planned encounters. Support after donation, such as updates on organ transplantation, early mental health checks and continued connection to donor organizations, could be improved. We derived 20 suggestions for improving the organ donation process, derived from interviews with family members of pediatric and adult organ donors. Interpretation: We found gaps in family support during end-of-life and donation care. Feelings of abandonment, lack of support and poor-to-little follow-up provide the empirical findings needed for hospitals and organ donor organizations to provide bettersupporttodonorfamilies., In Canada, 2 pathways to deceased organ donation exist. Families can be approached about organ donation after either neurologic determination of death or a decision to withdraw life-sustaining therapy. Family [...]

Published
2022
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32. Casemix, management, and mortality of patients receiving emergency neurosurgery for traumatic brain injury in the Global Neurotrauma Outcomes Study: a prospective observational cohort study

Author

Abbas, Ghayur, Abdallah, Omar Ibrahim, Abdel-Lateef, Ahmed, Abdifatah, Khalif, Abdullateef, Awfa, Abeygunaratne, Ruvini, Aboellil, Mostafa, Adam, Abass, Adams, Robert, Adeleye, Amos, Adeolu, Augustine, Adji, Novan Krisno, Afianti, Nur, Agarwal, Sudarsan, Aghadi, Ifeanyi Kene, Aguilar, Paúl Martín Méndez, Ahmad, Syeda Rida, Ahmed, Daniyal, Ahmed, Nafees, Aizaz, Haider, Aji, Yunus Kuntawi, Alamri, Alex, Alberto, Augusto Jacinto Mussindo, Alcocer, Luis Alcocer, Alfaro, Lesly Gonzales, Al-Habib, Amro, Alhourani, Ahmad, Ali, Syed Muhammad Rafay, Alkherayf, Fahad, AlMenabbawy, Ahmed, Alshareef, Aliyah, Aminullah, Muhammad Adil s/o, Amjad, Madeha, Amorim, Robson Luis Oliveira de, Anbazhagan, Sathiaprabhu, Andrade, Almir, Antar, Waleed, Anyomih, Theophilus T.K., Aoun, Salah, Apriawan, Tedy, Armocida, Daniele, Arnold, Paul, Arraez, Miguel, Assefa, Temesgen, Asser, Andres, Athiththan, S.P., Attanayake, Deepal, Aung, Maung Maung, Avi, Allan, Ayala, Victor Enrique Antolinez, Azab, Mohammed, Azam, Gaousul, Azharuddin, Mohd, Badejo, Olukemi, Badran, Mohamed, Baig, Azam Ali, Baig, Rehman Ali, Bajaj, Ankur, Baker, Paul, Bala, Renu, Balasa, Artur, Balchin, Ross, Balogun, James, Ban, Vin Shen, Bandi, Bharath Kumar Reddy, Bandyopadhyay, Soham, Bank, Matthew, Barthelemy, Ernest, Bashir, Mohammed Talha, Basso, Luciano Silveira, Basu, Surajit, Batista, Auricelio, Bauer, Marlies, Bavishi, Devi, Beane, Abi, Bejell, Shmuel, Belachew, Anteneh, Belli, Antonio, Belouaer, Amani, Bendahane, Najia El Abbadi, Benjamin, Okanga, Benslimane, Youssef, Benyaiche, Chaymae, Bernucci, Claudio, Berra, Luigi Valentino, Bhebe, Arnold, Bimpis, Alexios, Blanaru, Diana, Bonfim, Jean Claude, Borba, Luis A B, Borcek, Alp Ozgun, Borotto, Erika, Bouhuwaish, Ahmad Elmabri Mohammad, Bourilhon, Facundo, Brachini, Gioia, Breedon, Joshua, Broger, Maximilian, Brunetto, Giacoma Maria Floriana, Bruzzaniti, Placido, Budohoska, Natalia, Burhan, Hira, Calatroni, Maximiliano Luis, Camargo, Catherine, Cappai, Pier Francesco, Cardali, Salvatore Massimiliano, Castaño-Leon, Ana M, Cederberg, David, Celaya, Mikel, Cenzato, Marco, Challa, Lakshmi Madhavi, Charest, Dhanny, Chaurasia, Bipin, Chenna, Rabah, Cherian, Iype, Ching'o, Juliana Henry, Chotai, Tejas, Choudhary, Ajay, Choudhary, Nabeel, Choumin, Florence, Cigic, Tomislav, Ciro, Juan, Conti, Carlo, Corrêa, Antônio Carlos de Souza, Cossu, Giulia, Couto, Maíra Piani, Cruz, Aurora, D'Silva, Divya, D'Aliberti, Giuseppe Antonio, Dampha, Lamin, Daniel, Roy Thomas, Dapaah, Andrew, Darbar, Aneela, Dascalu, Gabriel, Dauda, Happy Amos, Davies, Owain, Delgado-Babiano, Andrea, Dengl, Markus, Despotovic, Marko, Devi, Indira, Dias, Celeste, Dirar, Mohamed, Dissanayake, Melina, Djimbaye, Hananiah, Dockrell, Simon, Dolachee, Ali, Dolgopolova, Julija, Dolgun, Muge, Dow, Abdalrouf, Drusiani, Davide, Dugan, Artjom, Duong, Dinh Tuan, Duong, Trung Kien, Dziedzic, Tomasz, Ebrahim, Ali, El Fatemi, Nizar, El Helou, Antonios El, El Maaqili, Rachid El, El Mostarchid, Brahim El, El Ouahabi, Abdessamad El, Elbaroody, Mohammad, El-Fiki, Ahmed, El-Garci, Ahmed, El-Ghandour, Nasser M.F., Elhadi, Muhammed, Elleder, Vanessa, Elrais, Safa, El-shazly, Mohamed, Elshenawy, Mohamed, Elshitany, Hesham, El-Sobky, Omar, Emhamed, Marwa, Enicker, Basil, Erdogan, Onur, Ertl, Sebastian, Esene, Ignatius, Espinosa, Omar Ocampo, Fadalla, Tarig, Fadelalla, Mohammed, Faleiro, Rodrigo Moreira, Fatima, Nida, Fawaz, Charbel, Fentaw, Assefa, Fernandez, Carla Eiriz, Ferreira, Ana, Ferri, Francesco, Figaji, Tony, Filho, Emerson L B, Fin, Loic, Fisher, Benjamin, Fitra, Fitra, Flores, Alexis Palpan, Florian, Ioan Stefan, Fontana, Vincenzo, Ford, Lauren, Fountain, Daniel, Frade, Jose Maria Roda, Fratto, Antonio, Freyschlag, Christian, Gabin, Aranzazu Sánchez, Gallagher, Clare, Ganau, Mario, Gandia-Gonzalez, Maria Luisa, Garcia, Andoni, Garcia, Borja Hernandez, Garusinghe, Sanjeewa, Gebreegziabher, Biniam, Gelb, Adrian, George, Jerome St, Germanò, Antonino Francesco, Ghetti, Ilaria, Ghimire, Prajwal, Giammarusti, Alessandro, Gil, Jose Luis, Gkolia, Panagiota, Godebo, Yoseph, Gollapudi, Prakash Rao, Golubovic, Jagos, Gomes, Jeremias Fernando, Gonzales, Javier, Gormley, William, Gots, Alexander, Gribaudi, Giulia Letizia, Griswold, Dylan, Gritti, Paolo, Grobler, Ruan, Gunawan, Rudy, Hailemichael, Birhanu, Hakkou, Elmehdi, Haley, Mark, Hamdan, Alhafidz, Hammed, Ali, Hamouda, Waeel, Hamzah, Nurul Ashikin, Han, Nyein Latt, Hanalioglu, Sahin, Haniffa, Rashan, Hanko, Martin, Hanrahan, John, Hardcastle, Timothy, Hassani, Fahd Derkaoui, Heidecke, Volkmar, Helseth, Eirik, Hernández-Hernández, Miguel Ángel, Hickman, Zachary, Hoang, Le Minh Chau, Hollinger, Alexa, Horakova, Lenka, Hossain-Ibrahim, Kismet, Hou, Boru, Hoz, Samer, Hsu, Janine, Hunn, Martin, Hussain, Madiha, Iacopino, Giorgia, Ideta, Mylena Miki Lopes, Iglesias, Irene, Ilunga, Ali, Imtiaz, Nafiz, Islam, Rafiza, Ivashchenko, Serge, Izirouel, Karim, Jabal, Mohamed Sobhi, Jabal, Soubhi, Jabang, John Nute, Jamjoom, Aimun, Jan, Irfan, Jarju, Landing BM, Javed, Saad, Jelaca, Bojan, Jhawar, Sukhdeep Singh, Jiang, Ting Ting, Jimenez, Fernando, Jiris, Jorge, Jithoo, Ron, Johnson, Walt, Joseph, Mathew, Joshi, Rameshman, Junttila, Eija, Jusabani, Mubashir, Kache, Stephen Akau, Kadali, Satyavara Prasad, Kalkmann, Gabriela F, Kamboh, Usman, Kandel, Hitham, Karakus, Ahmet Kamil, Kassa, Mengistu, Katila, Ari, Kato, Yoko, Keba, Martin, Kehoe, Kristy, Kertmen, Huseyin Hayri, Khafaji, Soha, Khajanchi, Monty, Khan, Mohammed, Khan, Muhammad Mukhtar, Khan, Sohail Daud, Khizar, Ahtesham, Khriesh, Amir, Kierońska, Sara, Kisanga, Paul, Kivevele, Boniface, Koczyk, Kacper, Koerling, Anna-Lucia, Koffenberger, Danielle, Kõiv, Kennet, Kõiv, Leho, Kolarovszki, Branislav, König, Marton, Könü-Leblebicioglu, Dilek, Koppala, Santhoshi Devi, Korhonen, Tommi, Kostkiewicz, Boguslaw, Kostyra, Kacper, Kotakadira, Srinivas, Kotha, Arjun Reddy, Kottakki, Madhu Narayana Rao, Krajcinovic, Nenad, Krakowiak, Michal, Kramer, Andreas, Krishnamoorthy, Selvamuthukumaran, Kumar, Ashok, Kumar, Pankaj, Kumar, Pradhumna, Kumarasinghe, Nilaksha, Kuncha, Gowtham, Kutty, Raja K., Laeke, Tsegazeab, Lafta, Ghazwan, Lammy, Simon, Lapolla, Pierfrancesco, Lardani, Jacopo, Lasica, Nebojsa, Lastrucci, Giancarlo, Launey, Yoann, Lavalle, Laura, Lawrence, Tim, Lazaro, Albert, Lebed, Vitalii, Leinonen, Ville, Lemeri, Lawrence, Levi, Leon, Lim, Jia Yi, Lim, Xiao Yi, Linares-Torres, Jorge, Lippa, Laura, Lisboa, Lurdes, Liu, Jinfang, Liu, Ziyuan, Lo, William B, Lodin, Jan, Loi, Federico, Londono, Daniella, Lopez, Pedro Antonio Gomez, López, Cristina Barceló, Lotbiniere-Bassett, Madeleine De, Lulens, Rihards, Luna, Facundo Hector, Luoto, Teemu, M.V., Vijaya Sekhar, Mabovula, Ndyebo, MacAllister, Matthew, Macie, Alcina Americo, Maduri, Rodolfo, Mahfoud, Moufid, Mahmood, Ashraf, Mahmoud, Fathia, Mahoney, Dominic, Makhlouf, Wissam, Malcolm, George, Malomo, Adefolarin, Malomo, Toluyemi, Mani, Manoranjitha Kumari, Marçal, Tomás Gazzinelli, Marchello, Jacopo, Marchesini, Nicolò, Marhold, Franz, Marklund, Niklas, Martín-Láez, Rubén, Mathaneswaran, Vickneswaran, Mato-Mañas, David José, Maye, Helen, McLean, Aaron Lawson, McMahon, Catherine, Mediratta, Saniya, Mehboob, Mehreen, Meneses, Alisson, Mentri, Nesrine, Mersha, Hagos, Mesa, Ana Milena, Meyer, Cristy, Millward, Christopher, Mimbir, Salomao Amone, Mingoli, Andrea, Mishra, Parashruram, Mishra, Tejesh, Misra, Basant, Mittal, Siddharth, Mohammed, Imran, Moldovan, Ioana, Molefe, Masechaba, Moles, Alexis, Moodley, Preston, Morales, Mario Augusto Narváez, Morgan, Lucy, Morillo, German Del Castillo, Moustafa, Wahab, Moustakis, Nikolaos, Mrichi, Salma, Munjal, Satya Shiva, Muntaka, Abdul-Jalilu Mohammed, Naicker, Denver, Nakashima, Paulo E H, Nandigama, Pratap Kumar, Nash, Samantha, Negoi, Ionut, Negoita, Valetina, Neupane, Samundra, Nguyen, Manh Hung, Niantiarno, Fajar Herbowo, Noble, Abbi, Nor, Mohd Arman Muhamad, Nowak, Blazej, Oancea, Andrei, O'Brien, Frazer, Okere, Oghenekevwe, Olaya, Sandra, Oliveira, Leandro, Oliveira, Louise Makarem, Omar, Fatma, Ononeme, Okezi, Opšenák, René, Orlandini, Simone, Osama, Alrobah, Osei-Poku, Dorcas, Osman, Haytham, Otero, Alvaro, Ottenhausen, Malte, Otzri, Shuli, Outani, Oumaima, Owusu, Emmanuel Abem, Owusu-Agyemang, Kevin, Ozair, Ahmad, Ozoner, Baris, Paal, Elli, Paiva, Mauro Sérgio, Paiva, Wellingson, Pandey, Sharad, Pansini, Gastone, Pansini, Luigi, Pantel, Tobias, Pantelas, Nikolaos, Papadopoulos, Konstantinos, Papic, Vladimir, Park, Kee, Park, Nick, Paschoal, Eric Homero Albuquerque, Paschoalino, Mylla Christie de Oliveira, Pathi, Rajesh, Peethambaran, Anilkumar, Pereira, Thiago Andrade, Perez, Irene Panero, Pérez, Claudio José Piqueras, Periyasamy, Tamilanandh, Peron, Stefano, Phillips, Michael, Picazo, Sofía Sotos, Pinar, Ertugrul, Pinggera, Daniel, Piper, Rory, Pirakash, Pathmanesan, Popadic, Branko, Posti, Jussi P., Prabhakar, Rajmohan Bhanu, Pradeepan, Sivanesalingam, Prasad, Manjunath, Prieto, Paola Calvachi, Prince, Ron, Prontera, Andrea, Provaznikova, Eva, Quadros, Danilo, Quintero, Nezly Jadid Romero, Qureshi, Mahmood, Rabiel, Happiness, Rada, Gabriel, Ragavan, Sivagnanam, Rahman, Jueria, Ramadhan, Omar, Ramaswamy, Padma, Rashid, Sakina, Rathugamage, Jagath, Rätsep, Tõnu, Rauhala, Minna, Raza, Asif, Reddycherla, Naga Raju, Reen, Linus, Refaat, Mohamed, Regli, Luca, Ren, Haijun, Ria, Antonio, Ribeiro, Thales Francisco, Ricci, Alessandro, Richterová, Romana, Ringel, Florian, Robertson, Faith, Rocha, Catarina Mayrink Siqueira Cabral, Rogério, Juvenal de Souza, Romano, Adan Anibal, Rothemeyer, Sally, Rousseau, Gail Rousseau Gail, Roza, Ranette, Rueda, Kevin David Farelo, Ruiz, Raiza, Rundgren, Malin, Rzeplinski, Radoslaw, S.Chandran, Raj, Sadayandi, Ramesh Andi, Sage, William, Sagerer, André Norbert Josef, Sakar, Mustafa, Salami, Mohcine, Sale, Danjuma, Saleh, Youssuf, Sánchez-Viguera, Cristina, Sandila, Saning'o, Sanli, Ahmet Metin, Santi, Laura, Santoro, Antonio, Santos, Aieska Kellen Dantas Dos, Santos, Samir Cezimbra dos, Sanz, Borja, Sapkota, Shabal, Sasidharan, Gopalakrishnan, Sasillo, Ibrahim, Satoskar, Rajeev, Sayar, Ali Caner, Sayee, Vignesh, Scheichel, Florian, Schiavo, Felipe Lourenzon, Schupper, Alexander, Schwarz, Andreas, Scott, Teresa, Seeberger, Esther, Segundo, Claudionor Nogueira Costa, Seidu, Anwar Sadat, Selfa, Antonio, Selmi, Nazan Has, Selvarajah, Claudiya, Şengel, Necmiye, Seule, Martin, Severo, Luiz, Shah, Purva, Shahzad, Muhammad, Shangase, Thobekile, Sharma, Mayur, Shiban, Ehab, Shimber, Emnet, Shokunbi, Temitayo, Siddiqui, Kaynat, Sieg, Emily, Siegemund, Martin, Sikder, Shahidur Rahman, Silva, Ana Cristina Veiga, Silva, Ana, Silva, Pedro Alberto, Singh, Deepinder, Skadden, Carly, Skola, Josef, Skouteli, Eirini, Słoniewski, Pawel, Smith, Brandon, Solanki, Guirish, Solla, Davi Fontoura, Solla, Davi, Sonmez, Ozcan, Sönmez, Müge, Soon, Wai Cheong, Stefini, Roberto, Stienen, Martin Nikolaus, Stoica, Bogdan, Stovell, Matthew, Suarez, Maria Natalia, Sulaiman, Alaa, Suliman, Mazin, Sulistyanto, Adi, Sulubulut, Şeniz, Sungailaite, Sandra, Surbeck, Madlen, Szmuda, Tomasz, Taddei, Graziano, Tadele, Abraham, Taher, Ahmed Saleh Ahmed, Takala, Riikka, Talari, Krishna Murthy, Tan, Bih Huei, Tariciotti, Leonardo, Tarmohamed, Murad, Taroua, Oumayma, Tatti, Emiliano, Tenovuo, Olli, Tetri, Sami, Thakkar, Poojan, Thango, Nqobile, Thatikonda, Satish Kumar, Thesleff, Tuomo, Thomé, Claudius, Thornton, Owen, Timmons, Shelly, Timoteo, Eva Ercilio, Tingate, Campbell, Tliba, Souhil, Tolias, Christos, Toman, Emma, Torres, Ivan, Torres, Luis, Touissi, Youness, Touray, Musa, Tropeano, Maria Pia, Tsermoulas, Georgios, Tsitsipanis, Christos, Turkoglu, Mehmet Erhan, Uçkun, Özhan Merzuk, Ullman, Jamie, Ungureanu, Gheorghe, Urasa, Sarah, Ur-Rehman, Obaid, Uysal, Muhammed, Vakis, Antonios, Valeinis, Egils, Valluru, Vaishali, Vannoy, Debby, Vargas, Pablo, Varotsis, Phillipos, Varshney, Rahul, Vats, Atul, Veljanoski, Damjan, Venturini, Sara, Verma, Abhijit, Villa, Clara, Villa, Genaro, Villar, Sofia, Villard, Erin, Viruez, Antonio, Voglis, Stefanos, Vulekovic, Petar, Wadanamby, Saman, Wagner, Katherine, Walshe, Rebecca, Walter, Jan, Waseem, Marriam, Whitworth, Tony, Wijeyekoon, Ruwani, Williams, Adam, Wilson, Mark, Win, Sein, Winarso, Achmad Wahib Wahju, Ximenes, Abraão Wagner Pessoa, Yadav, Anurag, Yadav, Dipak, Yakoub, Kamal Makram, Yalcinkaya, Ali, Yan, Guizhong, Yaqoob, Eesha, Yepes, Carlos, Yılmaz, Ayfer Nazmiye, Yishak, Betelehem, Yousuf, Farhat Basheer, Zahari, Muhammad Zamzuri, Zakaria, Hussein, Zambonin, Diego, Zavatto, Luca, Zebian, Bassel, Zeitlberger, Anna Maria, Zhang, Furong, Zheng, Fengwei, Ziga, Michal, Clark, David, Joannides, Alexis, Adeleye, Amos Olufemi, Bajamal, Abdul Hafid, Bashford, Tom, Biluts, Hagos, Budohoski, Karol, Ercole, Ari, Fernández-Méndez, Rocío, Figaji, Anthony, Gupta, Deepak Kumar, Härtl, Roger, Iaccarino, Corrado, Khan, Tariq, Rubiano, Andrés, Shabani, Hamisi K, Sichizya, Kachinga, Tewari, Manoj, Tirsit, Abenezer, Thu, Myat, Tripathi, Manjul, Trivedi, Rikin, Devi, Bhagavatula Indira, Servadei, Franco, Menon, David, Kolias, Angelos, and Hutchinson, Peter

Published
2022
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33. Cerebrovascular pressure reactivity and brain tissue oxygen monitoring provide complementary information regarding the lower and upper limits of cerebral blood flow control in traumatic brain injury: a CAnadian High Resolution-TBI (CAHR-TBI) cohort study

Author

Gomez, Alwyn, Sekhon, Mypinder, Griesdale, Donald, Froese, Logan, Yang, Eleen, Thelin, Eric P., Raj, Rahul, Aries, Marcel, Gallagher, Clare, Bernard, Francis, Kramer, Andreas H., and Zeiler, Frederick A.

Published
2022
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42. Lessons from the CAGI‐4 Hopkins clinical panel challenge

Author

Chandonia, John‐Marc, Adhikari, Aashish, Carraro, Marco, Chhibber, Aparna, Cutting, Garry R, Fu, Yao, Gasparini, Alessandra, Jones, David T, Kramer, Andreas, Kundu, Kunal, Lam, Hugo YK, Leonardi, Emanuela, Moult, John, Pal, Lipika R, Searls, David B, Shah, Sohela, Sunyaev, Shamil, Tosatto, Silvio CE, Yin, Yizhou, and Buckley, Bethany A

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Clinical Sciences, Genetics, Clinical Research, 4.2 Evaluation of markers and technologies, Detection, screening and diagnosis, Computational Biology, Databases, Genetic, Genetic Predisposition to Disease, Genetic Testing, Humans, Phenotype, Sequence Analysis, DNA, CAGI, genetic testing, phenotype prediction, variant interpretation, Genetics & Heredity, Clinical sciences
Abstract

The CAGI-4 Hopkins clinical panel challenge was an attempt to assess state-of-the-art methods for clinical phenotype prediction from DNA sequence. Participants were provided with exonic sequences of 83 genes for 106 patients from the Johns Hopkins DNA Diagnostic Laboratory. Five groups participated in the challenge, predicting both the probability that each patient had each of the 14 possible classes of disease, as well as one or more causal variants. In cases where the Hopkins laboratory reported a variant, at least one predictor correctly identified the disease class in 36 of the 43 patients (84%). Even in cases where the Hopkins laboratory did not find a variant, at least one predictor correctly identified the class in 39 of the 63 patients (62%). Each prediction group correctly diagnosed at least one patient that was not successfully diagnosed by any other group. We discuss the causal variant predictions by different groups and their implications for further development of methods to assess variants of unknown significance. Our results suggest that clinically relevant variants may be missed when physicians order small panels targeted on a specific phenotype. We also quantify the false-positive rate of DNA-guided analysis in the absence of prior phenotypic indication.

Published
2017

46. Intracranial Pressure-Derived Cerebrovascular Reactivity Indices and Their Critical Thresholds: A Canadian High Resolution-Traumatic Brain Injury Validation Study

Author

Stein, Kevin Y., primary, Froese, Logan, additional, Sekhon, Mypinder, additional, Griesdale, Donald, additional, Thelin, Eric P., additional, Raj, Rahul, additional, Tas, Jeanette, additional, Aries, Marcel, additional, Gallagher, Clare, additional, Bernard, Francis, additional, Gomez, Alwyn, additional, Kramer, Andreas H., additional, and Zeiler, Frederick A., additional

Published
2023
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50. Variability in deceased donor care in Canada: a report of the Canada-DONATE cohort study

Author

D’Aragon, Frédérick, Lamontagne, Francois, Cook, Deborah, Dhanani, Sonny, Keenan, Sean, Chassé, Michaël, English, Shane, Burns, Karen E. A., Frenette, Anne Julie, Ball, Ian, Boyd, John Gordon, Masse, Marie-Hélène, Breau, Ruth, Akhtar, Aemal, Kramer, Andreas, Rochwerg, Bram, Lauzier, François, Kutsogiannis, Demetrios James, Ibrahim, Quazi, Hand, Lori, Zhou, Qi, and Meade, Maureen O.

Published
2020
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