1,539 results on '"Kramer, E"'
Search Results
2. Open-Label, Randomized, Multicenter, Phase III Study Comparing Oral Paclitaxel Plus Encequidar Versus Intravenous Paclitaxel in Patients With Metastatic Breast Cancer
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Rugo, Hope S, Umanzor, Gerardo A, Barrios, Francisco J, Vasallo, Rosa H, Chivalan, Marco A, Bejarano, Suyapa, Ramírez, Julio R, Fein, Luis, Kowalyszyn, Ruben D, Kramer, E Douglas, Wang, Hui, Kwan, Min-Fun R, Cutler, David L, and Investigators, for the Oraxol Study Consortium
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Digestive Diseases ,Clinical Research ,Liver Disease ,Clinical Trials and Supportive Activities ,Cancer ,Breast Cancer ,Evaluation of treatments and therapeutic interventions ,6.1 Pharmaceuticals ,Humans ,Female ,Breast Neoplasms ,Paclitaxel ,Progression-Free Survival ,Proportional Hazards Models ,Administration ,Intravenous ,Antineoplastic Combined Chemotherapy Protocols ,Oraxol Study Consortium Investigators ,Clinical Sciences ,Oncology and Carcinogenesis ,Oncology & Carcinogenesis - Abstract
PurposeIntravenous paclitaxel (IVpac) is complicated by neuropathy and requires premedication to prevent hypersensitivity-type reactions. Paclitaxel is poorly absorbed orally; encequidar (E), a novel P-glycoprotein pump inhibitor, allows oral absorption.MethodsA phase III open-label study comparing oral paclitaxel plus E (oPac + E) 205 mg/m2 paclitaxel plus 15 mg E methanesulfonate monohydrate 3 consecutive days per week versus IVpac 175 mg/m2 once every 3 weeks was performed. Women with metastatic breast cancer and adequate organ function, at least 1 year from last taxane, were randomly assigned 2:1 to oPac + E versus IVpac. The primary end point was confirmed radiographic response using RECIST 1.1, assessed by blinded independent central review. Secondary end points included progression-free survival (PFS) and overall survival (OS).ResultsFour hundred two patients from Latin America were enrolled (265 oPac + E, 137 IVpac); demographics and prior therapies were balanced. The confirmed response (intent-to-treat) was 36% for oPac + E versus 23% for IVpac (P = .01). The PFS was 8.4 versus 7.4 months, respectively (hazard ratio, 0.768; 95.5% CI, 0.584 to 1.01; P = .046), and the OS was 22.7 versus 16.5 months, respectively (hazard ratio, 0.794; 95.5% CI, 0.607 to 1.037; P = .08). Grade 3-4 adverse reactions were 55% with oPac + E and 53% with IVpac. oPac + E had lower incidence and severity of neuropathy (2% v 15% > grade 2) and alopecia (49% v 62% all grades) than IVpac but more nausea, vomiting, diarrhea, and neutropenic complications, particularly in patients with elevated liver enzymes. On-study deaths (8% oPac + E v 9% IVpac) were treatment-related in 3% and 0%, respectively.ConclusionoPac + E increased the confirmed tumor response versus IVpac, with trends in PFS and OS. Neuropathy was less frequent and severe with oPac + E; neutropenic serious infections were increased. Elevated liver enzymes at baseline predispose oPac + E patients to early neutropenia and serious infections (funded by Athenex, Inc; ClinicalTrials.gov identifier: NCT02594371).
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- 2023
3. Asteroid Diameters and Albedos from NEOWISE Reactivation Mission Years Six and Seven
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Masiero, Joseph R., Mainzer, A. K., Bauer, J. M., Cutri, R. M., Grav, T., Kramer, E., Pittichová, J., and Wright, E. L.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
We present diameters and albedos computed for the near-Earth and Main Belt asteroids observed by the Near-Earth Object Wide-field Infrared Survey Explorer (NEOWISE) spacecraft during the sixth and seventh years of its Reactivation mission. These diameters and albedos are calculated from fitting thermal models to NEOWISE observations of $199$ NEOs and $5851$ MBAs detected during the sixth year of the survey, and $175$ NEOs and $5861$ MBAs from the seventh year. Comparisons of the near-Earth object diameters derived from Reactivation data with those derived from the WISE cryogenic mission data show a $\sim30\%$ relative uncertainty. This larger uncertainty compared to data from the cryogenic mission is due to the need to assume a beaming parameter for the fits to the shorter wavelength data that the Reactivation mission is limited to. We also present an analysis of the orbital parameters of the Main Belt asteroids that have been discovered by NEOWISE during Reactivation, finding that these objects tend to be on orbits that result in their perihelia being far from the ecliptic, and thus missed by other surveys. To date, the NEOWISE Reactivation survey has provided thermal fits of $1415$ unique NEOs. Including the mission phases before spacecraft hibernation increases the count of unique NEOs characterized to $1845$ from WISE's launch to the present., Comment: Accepted to PSJ
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- 2021
4. Asteroid Diameters and Albedos from NEOWISE Reactivation Mission Years Four and Five
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Masiero, Joseph R., Mainzer, A. K., Bauer, J. M., Cutri, R. M., Grav, T., Kramer, E., Pittichová, J., Sonnett, S., and Wright, E. L.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
The Near-Earth Object Wide-field Infrared Survey Explorer (NEOWISE) spacecraft has been conducting a two-band thermal infrared survey to detect and characterize asteroids and comets since its reactivation in Dec 2013. Using the observations collected during the fourth and fifth years of the survey, our automated pipeline detected candidate moving objects which were verified and reported to the Minor Planet Center. Using these detections, we perform thermal modeling of each object from the near-Earth object and Main Belt asteroid populations to constrain their sizes. We present thermal model fits of asteroid diameters for 189 NEOs and 5831 MBAs detected during the fourth year of the survey, and 185 NEOs and 5776 MBAs from the fifth year. To date, the NEOWISE Reactivation survey has provided thermal model characterization for 957 unique NEOs. Including all phases of the original WISE survey brings the total to 1473 unique NEOs that have been characterized between 2010 and the present., Comment: Accepted for publication in the AAS Planetary Science Journal
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- 2020
5. A resurrection mission : N.T. Wright's eschatology and mission theology
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Kramer, E. J. David and Ziegler, Philip Gordon
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Resurrection ,Church ,Eschatology ,Evangelistic work ,Political theology - Abstract
The primary argument of this thesis is that N.T. Wright's eschatology and mission theology centre on Jesus' resurrection, suggesting that the divine salvific work follows a death and resurrection pattern. The secondary argument is that Wright is properly interpreted as a missionary theologian, whose corpus engages the Western Enlightenment context with a coherent account of the gospel. The thesis is advanced in three parts. In the first, Wright's method of worldview analysis, particularly his rendition of Second Temple Jewish basic beliefs, is expounded, and a narratival overview of his eschatology presented which highlights the centrality of Jesus' resurrection (chap. 1). Then, a systematic analysis of this eschatology is undertaken, in which Wright's strategic decision to build on Jesus' resurrection is critically tested and found to be sound, leading to a fivefold characterization of his eschatology (as Jewish, narratival, cosmological, Christological-Pneumatological, and missional) in which Jesus' resurrection is seen to be load-bearing at every point (chap. 2). In the second part, Wright's missional eschatology is expanded and the resurrection's relevance for its concomitant ecclesiology (chap. 3), evangelism (chap. 4), political theology (chap. 5), and ethics (chap. 6), analyzed and critiqued. In each of these areas, not only Wright's mission theology but also his praxis is considered, consistently evincing him as a missionary theologian. In the third part (chap. 7), in a more constructive mode, Wright's concept of the church's 'theologizing' task is compared to Paul Hiebert's concept of 'critical contextualization,' and the two are found to be commensurate. This allows for a reciprocal illumination, in which the missiological practice of critical contextualization is determined theologically by Wright's death and resurrection pattern and Wright's concept of 'theologizing' becomes transparent as an eminently missional activity and Wright himself as a missionary theologian.
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- 2020
6. Small and Nearby NEOs Observed by NEOWISE During the First Three Years of Survey: Physical Properties
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Masiero, Joseph R., Redwing, E., Mainzer, A. K., Bauer, J. M., Cutri, R. M., Grav, T., Kramer, E., Nugent, C. R., Sonnett, S., and Wright, E. L.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
Automated asteroid detection routines set requirements on the number of detections, signal-to-noise ratio, and the linearity of the expected motion in order to balance completeness, reliability, and time delay after data acquisition when identifying moving object tracklets. However, when the full-frame data from a survey are archived, they can be searched later for asteroids that were below the initial detection thresholds. We have conducted such a search of the first three years of the reactivated NEOWISE data, looking for near-Earth objects discovered by ground-based surveys that have previously unreported thermal infrared data. Using these measurements, we can then perform thermal modeling to measure the diameters and albedos of these objects. We present new physical properties for 116 Near-Earth Objects found in this search., Comment: Accepted for publication in AJ
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- 2018
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7. The zwicky transient facility: Science objectives
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Graham, MJ, Kulkarni, SR, Bellm, EC, Adams, SM, Barbarino, C, Blagorodnova, N, Bodewits, D, Bolin, B, Brady, PR, Cenko, SB, Chang, CK, Coughlin, MW, Kishalay De, K, Eadie, G, Farnham, TL, Feindt, U, Franckowiak, A, Fremling, C, Gezari, S, Ghosh, S, Goldstein, DA, Golkhou, VZ, Goobar, A, Ho, AYQ, Huppenkothen, D, Ivezić, Ž, Jones, RL, Juric, M, Kaplan, DL, Kasliwal, MM, Kelley, MSP, Kupfer, T, Lee, CD, Lin, HW, Lunnan, R, Mahabal, AA, Miller, AA, Ngeow, CC, Nugent, P, Ofek, EO, Prince, TA, Rauch, L, Van Roestel, J, Schulze, S, Singer, LP, Sollerman, J, Taddia, F, Yan, L, Ye, QZ, Yu, PC, Barlow, T, Bauer, J, Beck, R, Belicki, J, Biswas, R, Brinnel, V, Brooke, T, Bue, B, Bulla, M, Burruss, R, Connolly, A, Cromer, J, Cunningham, V, Dekany, R, Delacroix, A, Desai, V, Duev, DA, Feeney, M, Flynn, D, Frederick, S, Gal-Yam, A, Giomi, M, Groom, S, Hacopians, E, Hale, D, Helou, G, Henning, J, Hover, D, Hillenbrand, LA, Howell, J, Hung, T, Imel, D, Ip, WH, Jackson, E, Kaspi, S, Kaye, S, Kowalski, M, Kramer, E, Kuhn, M, Landry, W, Laher, RR, Mao, P, Masci, FJ, Monkewitz, S, Murphy, P, Nordin, J, Patterson, MT, Penprase, B, Porter, M, and Rebbapragada, U
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(stars:) supernovae: general ,surveys ,(galaxies:) quasars: general ,astro-ph.IM ,astro-ph.HE ,Astronomy & Astrophysics ,Astronomical and Space Sciences - Abstract
The Zwicky Transient Facility (ZTF), a public–private enterprise, is a new time-domain survey employing a dedicated camera on the Palomar 48-inch Schmidt telescope with a 47 deg2 field of view and an 8 second readout time. It is well positioned in the development of time-domain astronomy, offering operations at 10% of the scale and style of the Large Synoptic Survey Telescope (LSST) with a single 1-m class survey telescope. The public surveys will cover the observable northern sky every three nights in g and r filters and the visible Galactic plane every night in g and r. Alerts generated by these surveys are sent in real time to brokers. A consortium of universities that provided funding (“partnership”) are undertaking several boutique surveys. The combination of these surveys producing one million alerts per night allows for exploration of transient and variable astrophysical phenomena brighter than r∼20.5 on timescales of minutes to years. We describe the primary science objectives driving ZTF, including the physics of supernovae and relativistic explosions, multi-messenger astrophysics, supernova cosmology, active galactic nuclei, and tidal disruption events, stellar variability, and solar system objects.
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- 2019
8. The zwicky transient facility: System overview, performance, and first results
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Bellm, EC, Kulkarni, SR, Graham, MJ, Dekany, R, Smith, RM, Riddle, R, Masci, FJ, Helou, G, Prince, TA, Adams, SM, Barbarino, C, Barlow, T, Bauer, J, Beck, R, Belicki, J, Biswas, R, Blagorodnova, N, Bodewits, D, Bolin, B, Brinnel, V, Brooke, T, Bue, B, Bulla, M, Burruss, R, Cenko, SB, Chang, CK, Connolly, A, Coughlin, M, Cromer, J, Cunningham, V, De, K, Delacroix, A, Desai, V, Duev, DA, Eadie, G, Farnham, TL, Feeney, M, Feindt, U, Flynn, D, Franckowiak, A, Frederick, S, Fremling, C, Gal-Yam, A, Gezari, S, Giomi, M, Goldstein, DA, Golkhou, VZ, Goobar, A, Groom, S, Hacopians, E, Hale, D, Henning, J, Ho, AYQ, Hover, D, Howell, J, Hung, T, Huppenkothen, D, Imel, D, Ip, WH, Ivezić, Ž, Jackson, E, Jones, L, Juric, M, Kasliwal, MM, Kaspi, S, Kaye, S, Kelley, MSP, Kowalski, M, Kramer, E, Kupfer, T, Landry, W, Laher, RR, Lee, CD, Lin, HW, Lin, ZY, Lunnan, R, Mahabal, A, Mao, P, Miller, AA, Monkewitz, S, Murphy, P, Ngeow, CC, Nordin, J, Nugent, P, Ofek, E, Patterson, MT, Penprase, B, Porter, M, Rauch, L, Rebbapragada, U, Reiley, D, Rigault, M, Rodriguez, H, van Roestel, J, Rusholme, B, van Santen, J, Schulze, S, Shupe, DL, and Singer, LP
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instrumentation: photometers ,telescopes ,astro-ph.IM ,Astronomical And Space Sciences ,Astronomy & Astrophysics ,Astronomical and Space Sciences - Abstract
The Zwicky Transient Facility (ZTF) is a new optical time-domain survey that uses the Palomar 48 inch Schmidt telescope. A custom-built wide-field camera provides a 47 deg 2 field of view and 8 s readout time, yielding more than an order of magnitude improvement in survey speed relative to its predecessor survey, the Palomar Transient Factory. We describe the design and implementation of the camera and observing system. The ZTF data system at the Infrared Processing and Analysis Center provides near-real-time reduction to identify moving and varying objects. We outline the analysis pipelines, data products, and associated archive. Finally, we present on-sky performance analysis and first scientific results from commissioning and the early survey. ZTF’s public alert stream will serve as a useful precursor for that of the Large Synoptic Survey Telescope.
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- 2019
9. Solar system science with the Wide-Field InfraRed Survey Telescope (WFIRST)
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Holler, B. J., Milam, S. N., Bauer, J. M., Alcock, C., Bannister, M. T., Bjoraker, G. L., Bodewits, D., Bosh, A. S., Buie, M. W., Farnham, T. L., Haghighipour, N., Hardersen, P. S., Harris, A. W., Hirata, C. M., Hsieh, H. H., Kelley, M. S. P., Knight, M. M., Kramer, E. A., Longobardo, A., Nixon, C. A., Palomba, E., Protopapa, S., Quick, L. C., Ragozzine, D., Reddy, V., Rhodes, J. D., Rivkin, A. S., Sarid, G., Sickafoose, A. A., Simon, A. A., Thomas, C. A., Trilling, D. E., and West, R. A.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
We present a community-led assessment of the solar system investigations achievable with NASA's next-generation space telescope, the Wide Field InfraRed Survey Telescope (WFIRST). WFIRST will provide imaging, spectroscopic, and coronagraphic capabilities from 0.43-2.0 $\mu$m and will be a potential contemporary and eventual successor to JWST. Surveys of irregular satellites and minor bodies are where WFIRST will excel with its 0.28 deg$^2$ field of view Wide Field Instrument (WFI). Potential ground-breaking discoveries from WFIRST could include detection of the first minor bodies orbiting in the Inner Oort Cloud, identification of additional Earth Trojan asteroids, and the discovery and characterization of asteroid binary systems similar to Ida/Dactyl. Additional investigations into asteroids, giant planet satellites, Trojan asteroids, Centaurs, Kuiper Belt Objects, and comets are presented. Previous use of astrophysics assets for solar system science and synergies between WFIRST, LSST, JWST, and the proposed NEOCam mission are discussed. We also present the case for implementation of moving target tracking, a feature that will benefit from the heritage of JWST and enable a broader range of solar system observations., Comment: 58 pages, 14 figures, 7 tables
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- 2017
10. NEOWISE Reactivation Mission Year Three: Asteroid Diameters and Albedos
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Masiero, Joseph R., Nugent, C., Mainzer, A. K., Wright, E. L., Bauer, J. M., Cutri, R. M., Grav, T., Kramer, E., and Sonnett, S.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
The Near-Earth Object Wide-field Infrared Survey Explorer (NEOWISE) reactivation mission has completed its third year of surveying the sky in the thermal infrared for near-Earth asteroids and comets. NEOWISE collects simultaneous observations at 3.4 um and 4.6 um of solar system objects passing through its field of regard. These data allow for the determination of total thermal emission from bodies in the inner solar system, and thus the sizes of these objects. In this paper we present thermal model fits of asteroid diameters for 170 NEOs and 6110 MBAs detected during the third year of the survey, as well as the associated optical geometric albedos. We compare our results with previous thermal model results from NEOWISE for overlapping sample sets, as well as diameters determined through other independent methods, and find that our diameter measurements for NEOs agree to within 26% (1-sigma) of previously measured values. Diameters for the MBAs are within 17% (1-sigma). This brings the total number of unique near-Earth objects characterized by the NEOWISE survey to 541, surpassing the number observed during the fully cryogenic mission in 2010., Comment: Accepted for publication in AJ
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- 2017
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11. The 67P/Churyumov-Gerasimenko observation campaign in support of the Rosetta mission
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Snodgrass, C., A'Hearn, M. F., Aceituno, F., Afanasiev, V., Bagnulo, S., Bauer, J., Bergond, G., Besse, S., Biver, N., Bodewits, D., Boehnhardt, H., Bonev, B. P., Borisov, G., Carry, B., Casanova, V., Cochran, A., Conn, B. C., Davidsson, B., Davies, J. K., de León, J., de Mooij, E., de Val-Borro, M., Delacruz, M., DiSanti, M. A., Drew, J. E., Duffard, R., Edberg, N. J. T., Faggi, S., Feaga, L., Fitzsimmons, A., Fujiwara, H., Gibb, E. L., Gillon, M., Green, S. F., Guijarro, A., Guilbert-Lepoutre, A., Gutiérrez, P. J., Hadamcik, E., Hainaut, O., Haque, S., Hedrosa, R., Hines, D., Hopp, U., Hoyo, F., Hutsemékers, D., Hyland, M., Ivanova, O., Jehin, E., Jones, G. H., Keane, J. V., Kelley, M. S. P., Kiselev, N., Kleyna, J., Kluge, M., Knight, M. M., Kokotanekova, R., Koschny, D., Kramer, E., López-Moreno, J. J., Lacerda, P., Lara, L. M., Lasue, J., Lehto, H. J., Levasseur-Regourd, A. C., Licandro, J., Lin, Z. Y., Lister, T., Lowry, S. C., Mainzer, A., Manfroid, J., Marchant, J., McKay, A. J., McNeill, A., Meech, K. J., Micheli, M., Mohammed, I., Monguió, M., Moreno, F., Muñoz, O., Mumma, M. J., Nikolov, P., Opitom, C., Ortiz, J. L., Paganini, L., Pajuelo, M., Pozuelos, F. J., Protopapa, S., Pursimo, T., Rajkumar, B., Ramanjooloo, Y., Ramos, E., Ries, C., Riffeser, A., Rosenbush, V., Rousselot, P., Ryan, E. L., Santos-Sanz, P., Schleicher, D. G., Schmidt, M., Schulz, R., Sen, A. K., Somero, A., Sota, A., Stinson, A., Sunshine, J., Thompson, A., Tozzi, G. P., Tubiana, C., Villanueva, G. L., Wang, X., Wooden, D. H., Yagi, M., Yang, B., Zaprudin, B., and Zegmott, T. J.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
We present a summary of the campaign of remote observations that supported the European Space Agency's Rosetta mission. Telescopes across the globe (and in space) followed comet 67P/Churyumov-Gerasimenko from before Rosetta's arrival until nearly the end of mission in September 2016. These provided essential data for mission planning, large-scale context information for the coma and tails beyond the spacecraft, and a way to directly compare 67P with other comets. The observations revealed 67P to be a relatively `well behaved' comet, typical of Jupiter family comets and with activity patterns that repeat from orbit-to-orbit. Comparison between this large collection of telescopic observations and the in situ results from Rosetta will allow us to better understand comet coma chemistry and structure. This work is just beginning as the mission ends -- in this paper we present a summary of the ground-based observations and early results, and point to many questions that will be addressed in future studies., Comment: Author prepared version; final published version available at journal. 22 pages
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- 2017
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12. Observed asteroid surface area in the thermal infrared
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Nugent, C. R., Mainzer, A., Masiero, J., Wright, E. L., Bauer, J., Grav, T., Kramer, E. A., and Sonnett, S.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
The rapid accumulation of thermal infrared observations and shape models of asteroids has led to increased interest in thermophysical modeling. Most of these infrared observations are unresolved. We consider what fraction of an asteroid's surface area contributes the bulk of the emitted thermal flux for two model asteroids of different shapes over a range of thermal parameters. The resulting observed surface in the infrared is generally more fragmented than the area observed in visible wavelengths, indicating high sensitivity to shape. For objects with low values of the thermal parameter, small fractions of the surface contribute the majority of thermally emitted flux. Calculating observed areas could enable the production of spatially-resolved thermal inertia maps from non-resolved observations of asteroids., Comment: Accepted to The Astronomical Journal
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- 2016
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13. Xe MRI Reveals Regional Gas-exchange Abnormalities in Cystic Fibrosis Lung Disease
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Soderlund, S., primary, Ismail, B., additional, Willmering, M., additional, Kramer, E., additional, Woods, J.C., additional, Walkup, L., additional, and Cleveland, Z.I., additional
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- 2024
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14. Initial Experience of Sodium-Glucose Cotransporter 2 Inhibitors in Adolescents with Heart Failure Due to Muscular Dystrophy
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Chaudhary, A.A., primary, Kramer, E., additional, Weber, D., additional, Ahmed, H., additional, O'Connor, M.J., additional, Edelson, J.B., additional, Edwards, J.J., additional, Lin, K.Y., additional, Rossano, J.W., additional, Wittlieb-Weber, C.A., additional, and Berger, J.H., additional
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- 2024
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15. NEOWISE Reactivation Mission Year Two: Asteroid Diameters and Albedos
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Nugent, C. R., Mainzer, A., Bauer, J., Cutri, R. M., Kramer, E. A., Grav, T., Masiero, J., Sonnett, S., and Wright, E. L.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
The Near-Earth Object Wide-Field Infrared Survey Explorer (NEOWISE) mission continues to detect, track, and characterize minor planets. We present diameters and albedos calculated from observations taken during the second year since the spacecraft was reactivated in late 2013. These include 207 near-Earth asteroids and 8,885 other asteroids. $84\%$ of the near-Earth asteroids did not have previously measured diameters and albedos by the NEOWISE mission. Comparison of sizes and albedos calculated from NEOWISE measurements with those measured by occultations, spacecraft, and radar-derived shapes shows accuracy consistent with previous NEOWISE publications. Diameters and albedos fall within $ \pm \sim20\%$ and $\pm\sim40\%$, 1-sigma, respectively, of those measured by these alternate techniques. NEOWISE continues to preferentially discover near-Earth objects which are large ($>100$ m), and have low albedos., Comment: Accepted to AJ
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- 2016
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16. Strain-dependent damping in nanomechanical resonators from thin $\mathrm{MoS_2}$ crystals
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Kramer, E., van Dorp, D. J. J., van Leeuwen, R., and Venstra, W. J.
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Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
We investigate the effect of mechanical strain on the dynamics of thin $\mathrm{MoS_2}$ nanodrum resonators. Using a piezoelectric crystal, compressive and tensile biaxial strain is induced in initially flat and buckled devices. In the flat device, we observe a remarkable strain-dependence of the resonance line width, while the change in the resonance frequency is relatively small. In the buckled device, the strain-dependence of the damping is less pronounced, and a clear hysteresis is observed. The experiment suggests that geometric imperfections, such as microscopic wrinkles, could play a role in the strong dissipation observed in nanoresonators fabricated from 2-D materials., Comment: 11 pages, 3 figures
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- 2015
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17. NEOWISE Reactivation Mission Year One: Preliminary Asteroid Diameters and Albedos
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Nugent, C. R., Mainzer, A., Masiero, J., Bauer, J., Cutri, R. M., Grav, T., Kramer, E., Sonnett, S., Stevenson, R., and Wright, E. L.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
We present preliminary diameters and albedos for 7,959 asteroids detected in the first year of the NEOWISE Reactivation mission. 201 are near-Earth asteroids (NEAs). 7,758 are Main Belt or Mars-crossing asteroids. 17% of these objects have not been previously characterized using WISE or NEOWISE thermal measurements. Diameters are determined to an accuracy of ~20% or better. If good-quality H magnitudes are available, albedos can be determined to within ~40% or better., Comment: 42 pages, 5 figures
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- 2015
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18. Military Mores -- An Institutional Ethnography
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Jansen, Marenne Mei and Kramer, E. H.
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Military education is for most people an unknown process that takes place behind closed doors. Based on text analysis, eighteen months of ethnographic fieldwork, and interviews at the Netherlands Defence Academy, this article seeks to understand military education as a dynamic process between the cadets' experience and the institute. As such, this study can be understood as an institutional ethnography, intending to open the black-box of military education. This study shows that military education affects cadets in a powerful way. They quickly learn to navigate the 'underlife' of the institute by carefully avoiding confrontation with the official structures. In a final discussion, we identify two remarkable paradoxes -- "perfect imperfection" and "individual in the system" -- that we consider exemplary for the learning environment at the NLDA. We argue that the Defence Academy constitutes, in essence, a paradoxical learning environment that influences the character development of the cadets -- sometimes in unintended ways.
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- 2019
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19. Lingering grains of truth around comet 17P/Holmes
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Stevenson, R., Bauer, J. M., Kramer, E. A., Grav, T., Mainzer, A. K., and Masiero, J. R.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
Comet 17P/Holmes underwent a massive outburst in 2007 Oct., brightening by a factor of almost a million in under 48 hours. We used infrared images taken by the Wide-Field Survey Explorer mission to characterize the comet as it appeared at a heliocentric distance of 5.1 AU almost 3 years after the outburst. The comet appeared to be active with a coma and dust trail along the orbital plane. We constrained the diameter, albedo, and beaming parameter of the nucleus to 4.135 $\pm$ 0.610 km, 0.03 $\pm$ 0.01 and 1.03 $\pm$ 0.21, respectively. The properties of the nucleus are consistent with those of other Jupiter Family comets. The best-fit temperature of the coma was 134 $\pm$ 11 K, slightly higher than the blackbody temperature at that heliocentric distance. Using Finson-Probstein modeling we found that the morphology of the trail was consistent with ejection during the 2007 outburst and was made up of dust grains between 250 $\mu$m and a few cm in radius. The trail mass was $\sim$ 1.2 - 5.3 $\times$ 10$^{10}$ kg., Comment: Accepted to ApJ. 2 tables, 4 figures
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- 2014
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20. Introduction
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Kramer, E.-H., Molendijk, T., Kramer, E-H., Kramer, E.-H., Molendijk, T., and Kramer, E-H.
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Contains fulltext : 298998.pdf (Publisher’s version ) (Open Access)
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- 2023
21. Concluding reflections
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Kramer, E-H, Molendijk, T., Kramer, E-H., Kramer, E-H, Molendijk, T., and Kramer, E-H.
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Contains fulltext : 298997.pdf (Publisher’s version ) (Open Access)
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- 2023
22. Fabrication of flax fibre-reinforced cellulose propionate thermoplastic composites
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Woigk, W., Fuentes, C.A., Rion, J., Hegemann, D., van Vuure, A.W., Kramer, E., Dransfeld, C., and Masania, K.
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- 2019
- Full Text
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23. Characterization of Active Main Belt Object P/2012 F5 (Gibbs): A Possible Impacted Asteroid
- Author
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Stevenson, R., Kramer, E. A., Bauer, J. M., Masiero, J. R., and Mainzer, A. K.
- Subjects
Astrophysics - Earth and Planetary Astrophysics - Abstract
In this work we characterize the recently discovered active main belt object P/2012 F5 (Gibbs), which was discovered with a dust trail > 7' in length in the outer main belt, 7 months prior to aphelion. We use optical imaging obtained on UT 2012 March 27 to analyze the central condensation and the long trail. We find nuclear B-band and R-band apparent magnitudes of 20.96 and 19.93 mag, respectively, which give an upper limit on the radius of the nucleus of 2.1 km. The geometric cross-section of material in the trail was ~ 4 x 10^8 m^2, corresponding to a dust mass of ~ 5 x 10^7 kg. Analysis of infrared images taken by the Wide-Field Infrared Survey Explorer in September 2010 reveals that the object was below the detection limit, suggesting that it was less active than it was during 2012, or possibly inactive, just 6 months after it passed through perihelion. We set a 1-sigma upper limit on its radius during this time of 2.9 km. P/2012 F5 (Gibbs) is dynamically stable in the outer main belt on timescales of ~ 1 Gyr, pointing towards an asteroidal origin. We find that the morphology of the ejected dust is consistent with it being produced by a single event that occurred on UT 2011 July 7 $\pm$ 20 days, possibly as the result of a collision with a small impactor., Comment: 29 pages, 5 figures. Accepted for publication in ApJ
- Published
- 2012
- Full Text
- View/download PDF
24. The Difference Jesus Makes: Yuval Noah Harari and Wolfhart Pannenberg on the Shape of Universal History.
- Author
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Kramer, E. J. David
- Subjects
- *
CHRISTIANS , *CHRISTIAN identity - Abstract
The Christian confession of who Jesus is must be made in the contested space of conflicting accounts of history. This article compares the shape of universal history set out by Yuval Noah Harari with that of Wolfhart Pannenberg by sketching their accounts of human beginnings, the middle of history, and their view to the future. Harari's secular account can be summarized as the rise and fall of homo sapiens, as historical developments lead to techno‐humanism and dataism. Jesus Christ holds no significant place in this narrative. Pannenberg's theological interpretation of history sees it originating in God's self‐giving love, climaxing in the Son's revelation, and leading to a new creation. This comparison leads to five propositions on how Christians may speak of who Jesus Christ is today. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
25. A closer look at weight loss interventions in primary care: a systematic review and meta-analysis
- Author
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Perreault, Leigh, primary, Kramer, E. Seth, additional, Smith, Peter C., additional, Schmidt, Darren, additional, and Argyropoulos, Christos, additional
- Published
- 2023
- Full Text
- View/download PDF
26. 98 Neutrophil extracellular traps disrupt bronchial epithelial junctional integrity and promote infection
- Author
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Middleton, R., primary, Collins, M., additional, Imbrogno, M., additional, Kramer, E., additional, Brewington, J., additional, Meeker, J., additional, Morgan, H., additional, Ostmann, A., additional, Trapnell, B., additional, Mahajan, S., additional, Wozniak, D., additional, Clancy, J., additional, and Hudock, K., additional
- Published
- 2023
- Full Text
- View/download PDF
27. 168 Impact of TGF-β exposure on IL-6 secretion in cystic fibrosis airway epithelia
- Author
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Scharf, G., primary, Davidson, C., additional, Morgan, H., additional, Meeker, J., additional, Ostmann, A., additional, Brewington, J., additional, Hudock, K., additional, Clancy, J., additional, and Kramer, E., additional
- Published
- 2023
- Full Text
- View/download PDF
28. Towards aerospace grade thin-ply composites: Effect of ply thickness, fibre, matrix and interlayer toughening on strength and damage tolerance
- Author
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Cugnoni, J., Amacher, R., Kohler, S., Brunner, J., Kramer, E., Dransfeld, C., Smith, W., Scobbie, K., Sorensen, L., and Botsis, J.
- Published
- 2018
- Full Text
- View/download PDF
29. Longevity of composite build-ups without posts—10-year results of a practice-based study
- Author
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Wierichs, R. J., Kramer, E. J., Wolf, T. G., Naumann, M., and Meyer-Lueckel, H.
- Published
- 2019
- Full Text
- View/download PDF
30. Singularities, Structures and Scaling in Deformed Elastic m-Sheets
- Author
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DiDonna, B. A., Venkataramani, S. C., Witten, T. A., and Kramer, E. M.
- Subjects
Mathematical Physics ,Condensed Matter - Abstract
The crumpling of a thin sheet can be understood as the condensation of elastic energy into a network of ridges which meet in vertices. Elastic energy condensation should occur in response to compressive strain in elastic objects of any dimension greater than 1. We study elastic energy condensation numerically in 2-dimensional elastic sheets embedded in spatial dimensions 3 or 4 and 3-dimensional elastic sheets embedded in spatial dimensions 4 and higher. We represent a sheet as a lattice of nodes with an appropriate energy functional to impart stretching and bending rigidity. Minimum energy configurations are found for several different sets of boundary conditions. We observe two distinct behaviors of local energy density fall-off away from singular points, which we identify as cone scaling or ridge scaling. Using this analysis we demonstrate that there are marked differences in the forms of energy condensation depending on the embedding dimension., Comment: 31 pages, 19 figures, RevTeX4, submitted to PRE
- Published
- 2001
- Full Text
- View/download PDF
31. The Pin Groups in Physics: C, P, and T
- Author
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Berg, M., DeWitt-Morette, C., Gwo, S., and Kramer, E.
- Subjects
Mathematical Physics - Abstract
We review the role in physics of the Pin groups, double covers of the full Lorentz group. Pin(1,3) is to O(1,3) what Spin(1,3) is to SO(1,3). The existence of two Pin groups offers a classification of fermions based on their properties under space or time reversal finer than the classification based on their properties under orientation preserving Lorentz transformations -- provided one can design experiments that distinguish the two types of fermions. Many promising experimental setups give, for one reason or another, identical results for both types of fermions. Two notable positive results show that the existence of two Pin groups is relevant to physics: 1) In a neutrinoless double beta decay, the neutrino emitted and reabsorbed in the course of the interaction can only be described in terms of Pin(3,1). 2) If a space is topologically nontrivial, the vacuum expectation values of Fermi currents defined on this space can be totally different when described in terms of Pin(1,3) and Pin(3,1). Possibly more important than the two above predictions, the Pin groups provide a simple framework for the study of fermions; they make possible clear definitions of intrinsic parities and time reversal. A section on Pin groups in arbitrary spacetime dimensions is included., Comment: 109 pages, 14 figures
- Published
- 2000
- Full Text
- View/download PDF
32. Limitations on the smooth confinement of an unstretchable manifold
- Author
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Venkataramani, S. C., Witten, T. A., Kramer, E. M., and Geroch, R. P.
- Subjects
Mathematical Physics ,Mathematics - Differential Geometry - Abstract
We prove that an m-dimensional unit ball D^m in the Euclidean space {\mathbb R}^m cannot be isometrically embedded into a higher-dimensional Euclidean ball B_r^d \subset {\mathbb R}^d of radius r < 1/2 unless one of two conditions is met -- (1)The embedding manifold has dimension d >= 2m. (2) The embedding is not smooth. The proof uses differential geometry to show that if d<2m and the embedding is smooth and isometric, we can construct a line from the center of D^m to the boundary that is geodesic in both D^m and in the embedding manifold {\mathbb R}^d. Since such a line has length 1, the diameter of the embedding ball must exceed 1., Comment: 20 Pages, 3 Figures
- Published
- 2000
- Full Text
- View/download PDF
33. Art, industry and design : the role of Japanese and Anglo-Japanese textiles in Victorian Britain, 1862-1900
- Author
-
Kramer, E. A.
- Subjects
708 - Abstract
This thesis employs the model of textile culture to illuminate the artistic interaction between Japan and Great Britain as well as the economic, cultural, political and gender issues underpinning this interaction between the years of 1862 and 1900. The chapters move beyond a stylistic study of Japanese and Anglo- Japanese textiles by considering them in relation to a variety of contexts and artistic processes, including international exhibitions; museum, educational and private collections; the domestic interior; travel; their representation in British painting and their inspiration in British textile design and manufacture. When possible, case studies of designers and artists who not only appropriated Japanese elements in their work, but also visited Japan, are called upon to determine the extent to which such an experience inspired their work as opposed to the degree to which these visitors imposed their preconceived ideas on Japanese art, people and culture, and compare travellers' reception of Japan to perceptions of Japan commonly held in Victorian Britain. A number of theories strongly inform this thesis, including material and visual culture, consumption, postcolonial, and gender theories. In considering the role of Japanese and Anglo-Japanese textiles in Victorian British art, design and industry, the first chapter looks at the exhibition and reception of Japanese textiles and clothing at the international exhibitions, beginning with the London 1862 Exhibition, and asks how these events shaped British perceptions of Japanese national identity and contributed to the feminisation of its culture. The second chapter demonstrates how these perceptions informed the representation of Japanese textiles and kimono in British painting as well as how these textiles stylistically inspired painting. The third chapter contrasts the ways in which Japanese textiles provided ideas for new designs to the ways in which designers produced Anlgo-Japanese patterns fitting Victorian consumers' ideas of Japan. The fourth chapter enhances this discussion by comparing the production of Anglo-Japanese textiles for the luxury to those affordable to middle class consumers. This chapter considers the role of textile manufacturing firms in disseminating interest in the Japanese style. The final chapter discusses how female consumers employed Japanese and Anglo-Japanese textiles in the decoration of the domestic interior and argues that when women and Japan became further involved in the masculine- or European-dominated world of commerce, women through their consumption and Japan through its production, the artistic value of Japanese decorative art and women's taste was depreciated
- Published
- 2004
34. Sulforaphane formation and bioaccessibility are more affected by steaming time than meal composition during in vitro digestion of broccoli
- Author
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Sarvan, I., Kramer, E., Bouwmeester, H., Dekker, M., and Verkerk, R.
- Published
- 2017
- Full Text
- View/download PDF
35. Practice-Based Research Now: Purpose, Approach, and a Proposition
- Author
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Barnes, Megan, Domlesky, Anya, Harvey, Allison, Hwang, Lisa, Kramer, Eric, Mendenhall, Allyson, Plumb, Margaret, and Popowsky, Rebecca
- Published
- 2024
36. Pluto in Glory: Discovery of a Huge Opposition Surge
- Author
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Lund, M, Ciardi, D, Bauer, J, Kramer, E, Hicks, M, and Buratti, Bonnie
- Published
- 2020
37. Pluto in Glory: Discovery of a Huge Opposition Surge
- Author
-
Buratti, Bonnie, Hicks, M, Kramer, E, Bauer, J, Ciardi, D, and Lund, M
- Published
- 2020
38. Chasing Near-Earth Asteroids at the Bottom of the Sky
- Author
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Masiero, Joe, Mainzer, A.K, Bauer, J.M, Cutri, R, Grav, T, Kramer, E, Pittichova, J, and Sonnett, S
- Published
- 2020
39. Chasing Near-Earth Asteroids at the Bottom of the Sky
- Author
-
Sonnett, S, Pittichova, J, Kramer, E, Grav, T, Cutri, R, Bauer, J.M, Mainzer, A.K, and Masiero, Joe
- Abstract
UNKNOWN
- Published
- 2020
40. Haematopoietic stem cell transplantation for severe autoimmune diseases in children: A review of current literature, registry activity and future directions on behalf of the autoimmune diseases and paediatric diseases working parties of the European Society for Blood and Marrow Transplantation
- Author
-
Achini-Gutzwiller, F, Snowden, J, Corbacioglu, S, Greco, R, Alexander, T, Badoglio, M, Labopin, M, Abinun, M, Apte, S, Arnold, R, Domenech, A, Brierley, C, Burman, J, Castilla-Llorente, C, Cooper, N, Daghia, G, Daikeler, T, del Papa, N, de Vries-Bouwstra, J, Farge, D, Finke, J, Hagglund, H, Hawkey, C, Henes, J, Hiepe, F, Jessop, H, Kiely, D, Kazmi, M, Kirgizov, K, Kramer, E, Mancardi, G, Marjanovic, Z, Martin, R, Martin, T, Ma, D, Moore, J, Miller, P, Muraro, P, Oliveira, M, Polushin, A, Onida, F, Simoes, B, Puyade, M, Resnick, I, Ricart, E, Rovira, M, Saccardi, R, Saif, M, Sakellari, I, Sharrack, B, Snarski, E, Scherer, H, Sossa, C, Withers, B, Wulffraat, N, Zaccara, E, Amrolia, P, Ansari, M, Balduzzi, A, Dalassier, A, Dalle, J, Diaz, C, Feuchtinger, T, Locatelli, F, Lucchini, G, Galimard, J, Vincent, M, Handgretinger, R, Kleinschmidt, K, Lawitschka, A, Martinez, A, Peters, C, Rocha, V, Ruggeri, A, Sedlacek, P, Svec, P, Toporski, J, Yesilipek, A, Achini-Gutzwiller F. R., Snowden J. A., Corbacioglu S., Greco R., Alexander T., Snowden J., Badoglio M., Labopin M., Abinun M., Apte S., Arnold R., Domenech A., Brierley C., Burman J., Castilla-Llorente C., Cooper N., Daghia G., Daikeler T., del Papa N., de Vries-Bouwstra J., Farge D., Finke J., Hagglund H., Hawkey C., Henes J., Hiepe F., Jessop H., Kiely D., Kazmi M., Kirgizov K., Kramer E., Mancardi G., Marjanovic Z., Martin R., Martin T., Ma D., Moore J., Miller P., Muraro P., Oliveira M. -C., Polushin A., Onida F., Simoes B., Puyade M., Resnick I., Ricart E., Rovira M., Saccardi R., Saif M., Sakellari I., Sharrack B., Snarski E., Scherer H. U., Sossa C., Withers B., Wulffraat N., Zaccara E., Amrolia P., Ansari M., Balduzzi A., Dalassier A., Dalle J. -H., Diaz C. H., Feuchtinger T., Locatelli F., Lucchini G., Galimard J. -E., Vincent M. G., Handgretinger R., Kleinschmidt K., Lawitschka A., Martinez A. P., Peters C., Rocha V., Ruggeri A., Sedlacek P., Svec P., Toporski J., Yesilipek A., Achini-Gutzwiller, F, Snowden, J, Corbacioglu, S, Greco, R, Alexander, T, Badoglio, M, Labopin, M, Abinun, M, Apte, S, Arnold, R, Domenech, A, Brierley, C, Burman, J, Castilla-Llorente, C, Cooper, N, Daghia, G, Daikeler, T, del Papa, N, de Vries-Bouwstra, J, Farge, D, Finke, J, Hagglund, H, Hawkey, C, Henes, J, Hiepe, F, Jessop, H, Kiely, D, Kazmi, M, Kirgizov, K, Kramer, E, Mancardi, G, Marjanovic, Z, Martin, R, Martin, T, Ma, D, Moore, J, Miller, P, Muraro, P, Oliveira, M, Polushin, A, Onida, F, Simoes, B, Puyade, M, Resnick, I, Ricart, E, Rovira, M, Saccardi, R, Saif, M, Sakellari, I, Sharrack, B, Snarski, E, Scherer, H, Sossa, C, Withers, B, Wulffraat, N, Zaccara, E, Amrolia, P, Ansari, M, Balduzzi, A, Dalassier, A, Dalle, J, Diaz, C, Feuchtinger, T, Locatelli, F, Lucchini, G, Galimard, J, Vincent, M, Handgretinger, R, Kleinschmidt, K, Lawitschka, A, Martinez, A, Peters, C, Rocha, V, Ruggeri, A, Sedlacek, P, Svec, P, Toporski, J, Yesilipek, A, Achini-Gutzwiller F. R., Snowden J. A., Corbacioglu S., Greco R., Alexander T., Snowden J., Badoglio M., Labopin M., Abinun M., Apte S., Arnold R., Domenech A., Brierley C., Burman J., Castilla-Llorente C., Cooper N., Daghia G., Daikeler T., del Papa N., de Vries-Bouwstra J., Farge D., Finke J., Hagglund H., Hawkey C., Henes J., Hiepe F., Jessop H., Kiely D., Kazmi M., Kirgizov K., Kramer E., Mancardi G., Marjanovic Z., Martin R., Martin T., Ma D., Moore J., Miller P., Muraro P., Oliveira M. -C., Polushin A., Onida F., Simoes B., Puyade M., Resnick I., Ricart E., Rovira M., Saccardi R., Saif M., Sakellari I., Sharrack B., Snarski E., Scherer H. U., Sossa C., Withers B., Wulffraat N., Zaccara E., Amrolia P., Ansari M., Balduzzi A., Dalassier A., Dalle J. -H., Diaz C. H., Feuchtinger T., Locatelli F., Lucchini G., Galimard J. -E., Vincent M. G., Handgretinger R., Kleinschmidt K., Lawitschka A., Martinez A. P., Peters C., Rocha V., Ruggeri A., Sedlacek P., Svec P., Toporski J., and Yesilipek A.
- Abstract
Although modern clinical management strategies have improved the outcome of paediatric patients with severe autoimmune and inflammatory diseases over recent decades, a proportion will experience ongoing or recurrent/relapsing disease activity despite multiple therapies often leading to irreversible organ damage, and compromised quality of life, growth/development and long-term survival. Autologous and allogeneic haematopoietic stem cell transplantation (HSCT) have been used successfully to induce disease control and often apparent cure of severe treatment-refractory autoimmune diseases (ADs) in children. However, transplant-related outcomes are disease-dependent and long-term outcome data are limited in respect to efficacy and safety. Moreover, balancing risks of HSCT against AD prognosis with continually evolving non-transplant options is challenging. This review appraises published literature on HSCT strategies and outcomes in individual paediatric ADs. We also provide a summary of the European Society for Blood and Marrow Transplantation (EBMT) Registry, where 343 HSCT procedures (176 autologous and 167 allogeneic) have been reported in 326 children (<18 years) for a range of AD indications. HSCT is a promising treatment modality, with potential long-term disease control or cure, but therapy-related morbidity and mortality need to be reduced. Further research is warranted to establish the position of HSCT in paediatric ADs via registries and prospective clinical studies to support evidence-based interspeciality guidelines and recommendations.
- Published
- 2022
41. POS1449 CARDIOVASCULAR DISEASE IN PRIMARY SJÖGREN SYNDROME
- Author
-
Zippel, C. L., primary, Beider, S., additional, Kramer, E., additional, Konen, F. F., additional, Seeliger, T., additional, Skripuletz, T., additional, Hirsch, S., additional, Dopfer-Jablonka, A., additional, Witte, T., additional, Sonnenschein, K., additional, and Ernst, D., additional
- Published
- 2023
- Full Text
- View/download PDF
42. Waves in Magnetosheath Jets-Classification and the Search for Generation Mechanisms Using MMS Burst Mode Data
- Author
-
Kramer, E., Hamrin, M., Gunell, H., Karlsson, T., Steinvall, Konrad, Goncharov, O., André, Mats, Kramer, E., Hamrin, M., Gunell, H., Karlsson, T., Steinvall, Konrad, Goncharov, O., and André, Mats
- Abstract
Magnetosheath jets are localized dynamic pressure enhancements in the magnetosheath. We make use of the high time resolution burst mode data of the Magnetospheric Multiscale mission for an analysis of waves in plasmas associated with three magnetosheath jets. We find both electromagnetic and electrostatic waves over the frequency range from 0 to 4 kHz that can be probed by the instruments on board the MMS spacecraft. At high frequencies we find electrostatic solitary waves, electron acoustic waves, and whistler waves. Electron acoustic waves and whistler waves show the typical properties expected from theory assuming approximations of a homogeneous plasma and linearity. In addition, 0.2 Hz waves in the magnetic field, 1 Hz electromagnetic waves, and lower hybrid waves are observed. For these waves the approximation of a homogeneous plasma does not hold anymore and the observed waves show properties from several different basic wave modes. In addition, we investigate how the various types of waves are generated. We show evidence that, the 1 Hz waves are connected to gradients in the density and magnetic field. The whistler waves are generated by a butterfly-shaped pitch-angle distribution and the electron acoustic waves by a cold electron population. The lower hybrid waves are probably generated by currents at the boundary of the jets. As for the other waves we can only speculate about the generation mechanism due to limitations of the instruments. Studying waves in jets will help to address the microphysics in jets which can help to understand the evolution of jets better.
- Published
- 2023
- Full Text
- View/download PDF
43. Military trauma and the conflicted human condition: Moral injury as a window into violence, human nature and military ethics
- Author
-
Kramer, E-H, Molendijk, T., Kramer, E-H, and Molendijk, T.
- Abstract
Contains fulltext : 298999.pdf (Publisher’s version ) (Open Access)
- Published
- 2023
44. Violence in Extreme Conditions: Ethical Challenges in Military Practice
- Author
-
Kramer, E-H., Molendijk, T., Kramer, E-H., and Molendijk, T.
- Abstract
Contains fulltext : upload_in_progress_2066_298281.pdf (Publisher’s version ) (Closed access)
- Published
- 2023
45. Introduction.
- Author
-
Kramer, E-H. and Kramer, E-H.
- Subjects
- Institute for Management Research.
- Published
- 2023
46. Ecuadorianische Grubenottern der Gattung Bothriechis, Bothrops und Porthidium (Serpentes: Viperidae)
- Author
-
Schätti, B, Kramer, E, and BioStor
- Published
- 1993
47. A New pitiver from Ecuador, Bothriechis mahnertii n. sp
- Author
-
Schätti, B, Kramer, E, and BioStor
- Published
- 1991
48. Systematic remarks on a rare Crotalid snake from Ecuador, Bothriechis albocarinata (Shreve), with some comments on the generic arrangement of arboreal Neotropical pitvipers
- Author
-
Schätti, B, Kramer, E, Touzet, J-M, and BioStor
- Published
- 1990
49. Haematopoietic stem cell transplantation for severe autoimmune diseases in children : a review of current literature, registry activity and future directions on behalf of the autoimmune diseases and paediatric diseases working parties of the European Society for Blood and Marrow Transplantation
- Author
-
Achini‐Gutzwiller, FR, Snowden, JA, Corbacioglu, S, Greco, R, Alexander, T, Snowden, J, Badoglio, M, Labopin, M, Abinun, M, Apte, S, Arnold, R, Domenech, A, Brierley, C, Burman, J, Castilla‐Llorente, C, Cooper, N, Daghia, G, Daikeler, T, del Papa, N, de Vries‐Bouwstra, J, Farge, D, Finke, J, Hagglund, H, Hawkey, C, Henes, J, Hiepe, F, Jessop, H, Kiely, D, Kazmi, M, Kirgizov, K, Kramer, E, Mancardi, G, Marjanovic, Z, Martin, R, Martin, T, Ma, D, Moore, J, Miller, P, Muraro, P, Oliveira, M, Polushin, A, Onida, F, Simoes, B, Puyade, M, Resnick, I, Ricart, E, Rovira, M, Saccardi, R, Saif, M, Sakellari, I, Sharrack, B, Snarski, E, Scherer, HU, Sossa, C, Withers, B, Wulffraat, N, Zaccara, E, Amrolia, P, Ansari, M, Balduzzi, A, Dalassier, A, Dalle, J, Diaz, CH, Feuchtinger, T, Locatelli, F, Lucchini, G, Galimard, J, Vincent, MG, Handgretinger, R, Kleinschmidt, K, Lawitschka, A, Martinez, AP, Peters, C, Rocha, V, Ruggeri, A, Sedlacek, P, Svec, P, Toporski, J, Yesilipek, A, Achini-Gutzwiller, F, Snowden, J, Corbacioglu, S, Greco, R, Alexander, T, Badoglio, M, Labopin, M, Abinun, M, Apte, S, Arnold, R, Domenech, A, Brierley, C, Burman, J, Castilla-Llorente, C, Cooper, N, Daghia, G, Daikeler, T, del Papa, N, de Vries-Bouwstra, J, Farge, D, Finke, J, Hagglund, H, Hawkey, C, Henes, J, Hiepe, F, Jessop, H, Kiely, D, Kazmi, M, Kirgizov, K, Kramer, E, Mancardi, G, Marjanovic, Z, Martin, R, Martin, T, Ma, D, Moore, J, Miller, P, Muraro, P, Oliveira, M, Polushin, A, Onida, F, Simoes, B, Puyade, M, Resnick, I, Ricart, E, Rovira, M, Saccardi, R, Saif, M, Sakellari, I, Sharrack, B, Snarski, E, Scherer, H, Sossa, C, Withers, B, Wulffraat, N, Zaccara, E, Amrolia, P, Ansari, M, Balduzzi, A, Dalassier, A, Dalle, J, Diaz, C, Feuchtinger, T, Locatelli, F, Lucchini, G, Galimard, J, Vincent, M, Handgretinger, R, Kleinschmidt, K, Lawitschka, A, Martinez, A, Peters, C, Rocha, V, Ruggeri, A, Sedlacek, P, Svec, P, Toporski, J, and Yesilipek, A
- Subjects
autoimmune diseases, haematopoietic stem cell transplantation, paediatric ,ddc:610 ,paediatric ,surgical procedures, operative ,Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA ,haematopoietic stem cell transplantation ,610 Medizin ,autoimmune diseases ,autoimmune disease ,Hematology - Abstract
Although modern clinical management strategies have improved the outcome of paediatric patients with severe autoimmune and inflammatory diseases over recent decades, a proportion will experience ongoing or recurrent/relapsing disease activity despite multiple therapies often leading to irreversible organ damage, and compromised quality of life, growth/development and long-term survival. Autologous and allogeneic haematopoietic stem cell transplantation (HSCT) have been used successfully to induce disease control and often apparent cure of severe treatment-refractory autoimmune diseases (ADs) in children. However, transplant-related outcomes are disease-dependent and long-term outcome data are limited in respect to efficacy and safety. Moreover, balancing risks of HSCT against AD prognosis with continually evolving non-transplant options is challenging. This review appraises published literature on HSCT strategies and outcomes in individual paediatric ADs. We also provide a summary of the European Society for Blood and Marrow Transplantation (EBMT) Registry, where 343 HSCT procedures (176 autologous and 167 allogeneic) have been reported in 326 children (
- Published
- 2022
50. Alpha-1 antitrypsin limits neutrophil extracellular trap disruption of airway epithelial barrier function
- Author
-
Hudock, K. M., primary, Collins, M. S., additional, Imbrogno, M. A., additional, Kramer, E. L., additional, Brewington, J. J., additional, Ziady, A., additional, Zhang, N., additional, Snowball, J., additional, Xu, Y., additional, Carey, B. C., additional, Horio, Y., additional, O’Grady, S. M., additional, Kopras, E. J., additional, Meeker, J., additional, Morgan, H., additional, Ostmann, A. J., additional, Skala, E., additional, Siefert, M. E., additional, Na, C. L., additional, Davidson, C. R., additional, Gollomp, K., additional, Mangalmurti, N., additional, Trapnell, B. C., additional, and Clancy, J. P., additional
- Published
- 2023
- Full Text
- View/download PDF
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