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2. Amplification of the PLAG-family genes—PLAGL1 and PLAGL2—is a key feature of the novel tumor type CNS embryonal tumor with PLAGL amplification

Author

Keck, Michaela-Kristina, Sill, Martin, Wittmann, Andrea, Joshi, Piyush, Stichel, Damian, Beck, Pengbo, Okonechnikow, Konstantin, Sievers, Philipp, Wefers, Annika K, Roncaroli, Federico, Avula, Shivaram, McCabe, Martin G, Hayden, James T, Wesseling, Pieter, Øra, Ingrid, Nistér, Monica, Kranendonk, Mariëtte EG, Tops, Bastiaan BJ, Zapotocky, Michal, Zamecnik, Josef, Vasiljevic, Alexandre, Fenouil, Tanguy, Meyronet, David, von Hoff, Katja, Schüller, Ulrich, Loiseau, Hugues, Figarella-Branger, Dominique, Kramm, Christof M, Sturm, Dominik, Scheie, David, Rauramaa, Tuomas, Pesola, Jouni, Gojo, Johannes, Haberler, Christine, Brandner, Sebastian, Jacques, Tom, Sexton Oates, Alexandra, Saffery, Richard, Koscielniak, Ewa, Baker, Suzanne J, Yip, Stephen, Snuderl, Matija, Ud Din, Nasir, Samuel, David, Schramm, Kathrin, Blattner-Johnson, Mirjam, Selt, Florian, Ecker, Jonas, Milde, Till, von Deimling, Andreas, Korshunov, Andrey, Perry, Arie, Pfister, Stefan M, Sahm, Felix, Solomon, David A, and Jones, David TW

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Pediatric, Genetics, Rare Diseases, Pediatric Cancer, Cancer, Pediatric Research Initiative, Neurosciences, Brain Cancer, Brain Disorders, Child, Child, Preschool, Female, Humans, Infant, Male, Cell Cycle Proteins, Central Nervous System Neoplasms, DNA Methylation, DNA-Binding Proteins, Neuroectodermal Tumors, Primitive, RNA-Binding Proteins, Transcription Factors, Tumor Suppressor Proteins, Wnt Signaling Pathway, PLAGL1, PLAGL2, Molecular neuro-oncology, Pediatric cancer, Clinical Sciences, Neurology & Neurosurgery
Abstract

Pediatric central nervous system (CNS) tumors represent the most common cause of cancer-related death in children aged 0-14 years. They differ from their adult counterparts, showing extensive clinical and molecular heterogeneity as well as a challenging histopathological spectrum that often impairs accurate diagnosis. Here, we use DNA methylation-based CNS tumor classification in combination with copy number, RNA-seq, and ChIP-seq analysis to characterize a newly identified CNS tumor type. In addition, we report histology, patient characteristics, and survival data in this tumor type. We describe a biologically distinct pediatric CNS tumor type (n = 31 cases) that is characterized by focal high-level amplification and resultant overexpression of either PLAGL1 or PLAGL2, and an absence of recurrent genetic alterations characteristic of other pediatric CNS tumor types. Both genes act as transcription factors for a regulatory subset of imprinted genes (IGs), components of the Wnt/β-Catenin pathway, and the potential drug targets RET and CYP2W1, which are also specifically overexpressed in this tumor type. A derived PLAGL-specific gene expression signature indicates dysregulation of imprinting control and differentiation/development. These tumors occurred throughout the neuroaxis including the cerebral hemispheres, cerebellum, and brainstem, and were predominantly composed of primitive embryonal-like cells lacking robust expression of markers of glial or neuronal differentiation (e.g., GFAP, OLIG2, and synaptophysin). Tumors with PLAGL1 amplification were typically diagnosed during adolescence (median age 10.5 years), whereas those with PLAGL2 amplification were diagnosed during early childhood (median age 2 years). The 10-year overall survival was 66% for PLAGL1-amplified tumors, 25% for PLAGL2-amplified tumors, 18% for male patients, and 82% for female patients. In summary, we describe a new type of biologically distinct CNS tumor characterized by PLAGL1/2 amplification that occurs predominantly in infants and toddlers (PLAGL2) or adolescents (PLAGL1) which we consider best classified as a CNS embryonal tumor and which is associated with intermediate survival. The cell of origin and optimal treatment strategies remain to be defined.

Published
2023

3. General support of physical exercise programs in pediatric oncology but differences in perception by childhood cancer care professionals at European and North-African/Arab centers

Author

El-Ayadi, Moatasem, Druivenga, Kyra, Perwein, Thomas, Nussbaumer, Gunther, Spreafico, Filippo, Massimino, Maura, Fadel, Shady, Amayiri, Nisreen, Khoubila, Nisrine, Hessissen, Laila, Chamdine, Omar, Rodríguez, Natàlia, Valls, Gemma Calaf, Morales la Madrid, Andres, Dahl, Christine, Hargrave, Darren, Szychot, Elwira, Bailey, Simon, van Vuurden, Dannis G., Benesch, Martin, Hunger, Ina, Kühnle, Ingrid, Mascher, Simone, Maggio, Albane Bertha Rosa, von Bueren, André O., and Kramm, Christof M.

Published
2024
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5. Multiomic neuropathology improves diagnostic accuracy in pediatric neuro-oncology

Author

Sturm, Dominik, Capper, David, Andreiuolo, Felipe, Gessi, Marco, Kölsche, Christian, Reinhardt, Annekathrin, Sievers, Philipp, Wefers, Annika K., Ebrahimi, Azadeh, Suwala, Abigail K., Gielen, Gerrit H., Sill, Martin, Schrimpf, Daniel, Stichel, Damian, Hovestadt, Volker, Daenekas, Bjarne, Rode, Agata, Hamelmann, Stefan, Previti, Christopher, Jäger, Natalie, Buchhalter, Ivo, Blattner-Johnson, Mirjam, Jones, Barbara C., Warmuth-Metz, Monika, Bison, Brigitte, Grund, Kerstin, Sutter, Christian, Hirsch, Steffen, Dikow, Nicola, Hasselblatt, Martin, Schüller, Ulrich, Koch, Arend, Gerber, Nicolas U., White, Christine L., Buntine, Molly K., Kinross, Kathryn, Algar, Elizabeth M., Hansford, Jordan R., Gottardo, Nicholas G., Schuhmann, Martin U., Thomale, Ulrich W., Hernáiz Driever, Pablo, Gnekow, Astrid, Witt, Olaf, Müller, Hermann L., Calaminus, Gabriele, Fleischhack, Gudrun, Kordes, Uwe, Mynarek, Martin, Rutkowski, Stefan, Frühwald, Michael C., Kramm, Christof M., von Deimling, Andreas, Pietsch, Torsten, Sahm, Felix, Pfister, Stefan M., and Jones, David. T. W.

Published
2023
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6. Correction to: Amplification of the PLAG-family genes—PLAGL1 and PLAGL2—is a key feature of the novel tumor type CNS embryonal tumor with PLAGL amplification

Author

Keck, Michaela-Kristina, Sill, Martin, Wittmann, Andrea, Joshi, Piyush, Stichel, Damian, Beck, Pengbo, Okonechnikow, Konstantin, Sievers, Philipp, Wefers, Annika K., Roncaroli, Federico, Avula, Shivaram, McCabe, Martin G., Hayden, James T., Wesseling, Pieter, Øra, Ingrid, Nistér, Monica, Kranendonk, Mariëtte E. G., Tops, Bastiaan B. J., Zapotocky, Michal, Zamecnik, Josef, Vasiljevic, Alexandre, Fenouil, Tanguy, Meyronet, David, von Hoff, Katja, Schüller, Ulrich, Loiseau, Hugues, Figarella-Branger, Dominique, Kramm, Christof M., Sturm, Dominik, Scheie, David, Rauramaa, Tuomas, Pesola, Jouni, Gojo, Johannes, Haberler, Christine, Brandner, Sebastian, Jacques, Tom, Sexton Oates, Alexandra, Saffery, Richard, Koscielniak, Ewa, Baker, Suzanne J., Yip, Stephen, Snuderl, Matija, Ud Din, Nasir, Samuel, David, Schramm, Kathrin, Blattner-Johnson, Mirjam, Selt, Florian, Ecker, Jonas, Milde, Till, von Deimling, Andreas, Korshunov, Andrey, Perry, Arie, Pfister, Stefan M., Sahm, Felix, Solomon, David A., and Jones, David T. W.

Published
2023
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8. A subset of pediatric-type thalamic gliomas share a distinct DNA methylation profile, H3K27me3 loss and frequent alteration of EGFR.

Author

Sievers, Philipp, Sill, Martin, Schrimpf, Daniel, Stichel, Damian, Reuss, David E, Sturm, Dominik, Hench, Jürgen, Frank, Stephan, Krskova, Lenka, Vicha, Ales, Zapotocky, Michal, Bison, Brigitte, Castel, David, Grill, Jacques, Debily, Marie-Anne, Harter, Patrick N, Snuderl, Matija, Kramm, Christof M, Reifenberger, Guido, Korshunov, Andrey, Jabado, Nada, Wesseling, Pieter, Wick, Wolfgang, Solomon, David A, Perry, Arie, Jacques, Thomas S, Jones, Chris, Witt, Olaf, Pfister, Stefan M, von Deimling, Andreas, Jones, David TW, and Sahm, Felix

Subjects
Brain Disorders, Pediatric Cancer, Cancer, Pediatric, Brain Cancer, Rare Diseases, Genetics, Neurosciences, Brain Neoplasms, Child, DNA Methylation, ErbB Receptors, Genes, erbB-1, Glioma, Histones, Humans, Mutation, Thalamus, (bi)thalamic, EGFR mutation, H3 K27M mutation, K27me3, pediatric-type high-grade glioma, EGFR mutation, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

BackgroundMalignant astrocytic gliomas in children show a remarkable biological and clinical diversity. Small in-frame insertions or missense mutations in the epidermal growth factor receptor gene (EGFR) have recently been identified in a distinct subset of pediatric-type bithalamic gliomas with a unique DNA methylation pattern.MethodsHere, we investigated an epigenetically homogeneous cohort of malignant gliomas (n = 58) distinct from other subtypes and enriched for pediatric cases and thalamic location, in comparison with this recently identified subtype of pediatric bithalamic gliomas.ResultsEGFR gene amplification was detected in 16/58 (27%) tumors, and missense mutations or small in-frame insertions in EGFR were found in 20/30 tumors with available sequencing data (67%; 5 of them co-occurring with EGFR amplification). Additionally, 8 of the 30 tumors (27%) harbored an H3.1 or H3.3 K27M mutation (6 of them with a concomitant EGFR alteration). All tumors tested showed loss of H3K27me3 staining, with evidence of overexpression of the EZH inhibitory protein (EZHIP) in the H3 wildtype cases. Although some tumors indeed showed a bithalamic growth pattern, a significant proportion of tumors occurred in the unilateral thalamus or in other (predominantly midline) locations.ConclusionsOur findings present a distinct molecular class of pediatric-type malignant gliomas largely overlapping with the recently reported bithalamic gliomas characterized by EGFR alteration, but additionally showing a broader spectrum of EGFR alterations and tumor localization. Global H3K27me3 loss in this group appears to be mediated by either H3 K27 mutation or EZHIP overexpression. EGFR inhibition may represent a potential therapeutic strategy in these highly aggressive gliomas.

Published
2021

9. Author Correction: Multiomic neuropathology improves diagnostic accuracy in pediatric neuro-oncology

Author

Sturm, Dominik, Capper, David, Andreiuolo, Felipe, Gessi, Marco, Kölsche, Christian, Reinhardt, Annekathrin, Sievers, Philipp, Wefers, Annika K., Ebrahimi, Azadeh, Suwala, Abigail K., Gielen, Gerrit H., Sill, Martin, Schrimpf, Daniel, Stichel, Damian, Hovestadt, Volker, Daenekas, Bjarne, Rode, Agata, Hamelmann, Stefan, Previti, Christopher, Jäger, Natalie, Buchhalter, Ivo, Blattner-Johnson, Mirjam, Jones, Barbara C., Warmuth-Metz, Monika, Bison, Brigitte, Grund, Kerstin, Sutter, Christian, Hirsch, Steffen, Dikow, Nicola, Hasselblatt, Martin, Schüller, Ulrich, Koch, Arend, Gerber, Nicolas U., White, Christine L., Buntine, Molly K., Kinross, Kathryn, Algar, Elizabeth M., Hansford, Jordan R., Gottardo, Nicholas G., Schuhmann, Martin U., Thomale, Ulrich W., Hernáiz Driever, Pablo, Gnekow, Astrid, Witt, Olaf, Müller, Hermann L., Calaminus, Gabriele, Fleischhack, Gudrun, Kordes, Uwe, Mynarek, Martin, Rutkowski, Stefan, Frühwald, Michael C., Kramm, Christof M., von Deimling, Andreas, Pietsch, Torsten, Sahm, Felix, Pfister, Stefan M., and Jones, David. T. W.

Published
2024
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12. Drug sensitivity profiling of 3D tumor tissue cultures in the pediatric precision oncology program INFORM

Author

Peterziel, Heike, Jamaladdin, Nora, ElHarouni, Dina, Gerloff, Xenia F., Herter, Sonja, Fiesel, Petra, Berker, Yannick, Blattner-Johnson, Mirjam, Schramm, Kathrin, Jones, Barbara C., Reuss, David, Turunen, Laura, Friedenauer, Aileen, Holland-Letz, Tim, Sill, Martin, Weiser, Lena, Previti, Christopher, Balasubramanian, Gnanaprakash, Gerber, Nicolas U., Gojo, Johannes, Hutter, Caroline, Øra, Ingrid, Lohi, Olli, Kattamis, Antonis, de Wilde, Bram, Westermann, Frank, Tippelt, Stephan, Graf, Norbert, Nathrath, Michaela, Sparber-Sauer, Monika, Sehested, Astrid, Kramm, Christof M., Dirksen, Uta, Kallioniemi, Olli, Pfister, Stefan M., van Tilburg, Cornelis M., Jones, David T. W., Saarela, Jani, Pietiäinen, Vilja, Jäger, Natalie, Schlesner, Matthias, Kopp-Schneider, Annette, Oppermann, Sina, Milde, Till, Witt, Olaf, and Oehme, Ina

Published
2022
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13. Pleomorphic xanthoastrocytoma is a heterogeneous entity with pTERT mutations prognosticating shorter survival

Author

Ebrahimi, Azadeh, Korshunov, Andrey, Reifenberger, Guido, Capper, David, Felsberg, Joerg, Trisolini, Elena, Pollo, Bianca, Calatozzolo, Chiara, Prinz, Marco, Staszewski, Ori, Schweizer, Leonille, Schittenhelm, Jens, Harter, Patrick N., Paulus, Werner, Thomas, Christian, Kohlhof-Meinecke, Patricia, Seiz-Rosenhagen, Marcel, Milde, Till, Casalini, Belén M., Suwala, Abigail, Wefers, Annika K., Reinhardt, Annekathrin, Sievers, Philipp, Kramm, Christof M., Etminam, Nima, Unterberg, Andreas, Wick, Wolfgang, Herold-Mende, Christel, Sturm, Dominik, Pfister, Stefan M., Sill, Martin, Jones, David T. W., Schrimpf, Daniel, Reuss, David E., Aldape, Ken, Abdullaev, Zied, Sahm, Felix, von Deimling, Andreas, and Stichel, Damian

Published
2022
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14. GOPC:ROS1 and other ROS1 fusions represent a rare but recurrent drug target in a variety of glioma types

Author

Sievers, Philipp, Stichel, Damian, Sill, Martin, Schrimpf, Daniel, Sturm, Dominik, Selt, Florian, Ecker, Jonas, Kazdal, Daniel, Miele, Evelina, Kranendonk, Mariëtte E. G., Tops, Bastiaan B. J., Kohlhof-Meinecke, Patricia, Beschorner, Rudi, Kramm, Christof M., Hasselblatt, Martin, Reifenberger, Guido, Capper, David, Wesseling, Pieter, Stenzinger, Albrecht, Milde, Till, Korshunov, Andrey, Witt, Olaf, Pfister, Stefan M., Wick, Wolfgang, von Deimling, Andreas, Jones, David T. W., and Sahm, Felix

Published
2021
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15. DNA methylation-based classification of central nervous system tumours.

Author

Capper, David, Jones, David TW, Sill, Martin, Hovestadt, Volker, Schrimpf, Daniel, Sturm, Dominik, Koelsche, Christian, Sahm, Felix, Chavez, Lukas, Reuss, David E, Kratz, Annekathrin, Wefers, Annika K, Huang, Kristin, Pajtler, Kristian W, Schweizer, Leonille, Stichel, Damian, Olar, Adriana, Engel, Nils W, Lindenberg, Kerstin, Harter, Patrick N, Braczynski, Anne K, Plate, Karl H, Dohmen, Hildegard, Garvalov, Boyan K, Coras, Roland, Hölsken, Annett, Hewer, Ekkehard, Bewerunge-Hudler, Melanie, Schick, Matthias, Fischer, Roger, Beschorner, Rudi, Schittenhelm, Jens, Staszewski, Ori, Wani, Khalida, Varlet, Pascale, Pages, Melanie, Temming, Petra, Lohmann, Dietmar, Selt, Florian, Witt, Hendrik, Milde, Till, Witt, Olaf, Aronica, Eleonora, Giangaspero, Felice, Rushing, Elisabeth, Scheurlen, Wolfram, Geisenberger, Christoph, Rodriguez, Fausto J, Becker, Albert, Preusser, Matthias, Haberler, Christine, Bjerkvig, Rolf, Cryan, Jane, Farrell, Michael, Deckert, Martina, Hench, Jürgen, Frank, Stephan, Serrano, Jonathan, Kannan, Kasthuri, Tsirigos, Aristotelis, Brück, Wolfgang, Hofer, Silvia, Brehmer, Stefanie, Seiz-Rosenhagen, Marcel, Hänggi, Daniel, Hans, Volkmar, Rozsnoki, Stephanie, Hansford, Jordan R, Kohlhof, Patricia, Kristensen, Bjarne W, Lechner, Matt, Lopes, Beatriz, Mawrin, Christian, Ketter, Ralf, Kulozik, Andreas, Khatib, Ziad, Heppner, Frank, Koch, Arend, Jouvet, Anne, Keohane, Catherine, Mühleisen, Helmut, Mueller, Wolf, Pohl, Ute, Prinz, Marco, Benner, Axel, Zapatka, Marc, Gottardo, Nicholas G, Driever, Pablo Hernáiz, Kramm, Christof M, Müller, Hermann L, Rutkowski, Stefan, von Hoff, Katja, Frühwald, Michael C, Gnekow, Astrid, Fleischhack, Gudrun, Tippelt, Stephan, Calaminus, Gabriele, Monoranu, Camelia-Maria, Perry, Arie, and Jones, Chris

Subjects
Humans, Central Nervous System Neoplasms, Cohort Studies, Reproducibility of Results, DNA Methylation, Adolescent, Adult, Aged, Aged, 80 and over, Middle Aged, Child, Child, Preschool, Infant, Female, Male, Young Adult, Unsupervised Machine Learning, and over, Preschool, General Science & Technology
Abstract

Accurate pathological diagnosis is crucial for optimal management of patients with cancer. For the approximately 100 known tumour types of the central nervous system, standardization of the diagnostic process has been shown to be particularly challenging-with substantial inter-observer variability in the histopathological diagnosis of many tumour types. Here we present a comprehensive approach for the DNA methylation-based classification of central nervous system tumours across all entities and age groups, and demonstrate its application in a routine diagnostic setting. We show that the availability of this method may have a substantial impact on diagnostic precision compared to standard methods, resulting in a change of diagnosis in up to 12% of prospective cases. For broader accessibility, we have designed a free online classifier tool, the use of which does not require any additional onsite data processing. Our results provide a blueprint for the generation of machine-learning-based tumour classifiers across other cancer entities, with the potential to fundamentally transform tumour pathology.

Published
2018

16. Gliomatosis cerebri in children: A poor prognostic phenotype of diffuse gliomas with a distinct molecular profile

Author

Nussbaumer, Gunther, primary, Benesch, Martin, additional, Grabovska, Yura, additional, Mackay, Alan, additional, Castel, David, additional, Grill, Jacques, additional, Alonso, Marta M, additional, Antonelli, Manila, additional, Bailey, Simon, additional, Baugh, Joshua N, additional, Biassoni, Veronica, additional, Blattner Johnson, Mirjam, additional, Broniscer, Alberto, additional, Carai, Andrea, additional, Colafati, Giovanna Stefania, additional, Colditz, Niclas, additional, Corbacioglu, Selim, additional, Crampsie, Shauna, additional, Entz-Werle, Natacha, additional, Eyrich, Matthias, additional, Friker, Lea L, additional, Frühwald, Michael C, additional, Garrè, Maria Luisa, additional, Gerber, Nicolas U, additional, Giangaspero, Felice, additional, Gil-da-Costa, Maria J, additional, Graf, Norbert, additional, Hargrave, Darren, additional, Hauser, Peter, additional, Herrlinger, Ulrich, additional, Hoffmann, Marion, additional, Hulleman, Esther, additional, Izquierdo, Elisa, additional, Jacobs, Sandra, additional, Karremann, Michael, additional, Kattamis, Antonis, additional, Kebudi, Rejin, additional, Kortmann, Rolf-Dieter, additional, Kwiecien, Robert, additional, Massimino, Maura, additional, Mastronuzzi, Angela, additional, Miele, Evelina, additional, Morana, Giovanni, additional, Noack, Claudia M, additional, Pentikainen, Virve, additional, Perwein, Thomas, additional, Pfister, Stefan M, additional, Pietsch, Torsten, additional, Roka, Kleoniki, additional, Rossi, Sabrina, additional, Rutkowski, Stefan, additional, Schiavello, Elisabetta, additional, Seidel, Clemens, additional, Štěrba, Jaroslav, additional, Sturm, Dominik, additional, Sumerauer, David, additional, Tacke, Anna, additional, Temelso, Sara, additional, Valentini, Chiara, additional, van Vuurden, Dannis, additional, Varlet, Pascale, additional, Veldhuijzen van Zanten, Sophie E M, additional, Vinci, Maria, additional, von Bueren, André O, additional, Warmuth-Metz, Monika, additional, Wesseling, Pieter, additional, Wiese, Maria, additional, Wolff, Johannes E A, additional, Zamecnik, Josef, additional, Morales La Madrid, Andrés, additional, Bison, Brigitte, additional, Gielen, Gerrit H, additional, Jones, David T W, additional, Jones, Chris, additional, and Kramm, Christof M, additional

Published
2024
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17. Initial presenting manifestations in 16,486 patients with inborn errors of immunity include infections and noninfectious manifestations

Author

Boztug, Kaan, Brunner, Juergen, Demel, Ulrike F., Förster-Waldl, Elisabeth, Gasteiger, Lukas M., Göschl, Lisa, Kojić, Marina, Schroll, Andrea, Seidel, Markus G., Wintergerst, Uwe, Wisgrill, Lukas, Sharapova, Svetlana O., Goffard, Jean-Christophe, Kerre, Tessa, Meyts, Isabelle, Roosens, Fine, Smet, Julie, Haerynck, Filomeen, Eric, Zelimir Pavle, Milenova, Veneta, Gagro, Alenka, Richter, Darko, Chovancova, Zita, Hlavackova, Eva, Litzman, Jiri, Milota, Tomas, Sediva, Anna, Elaziz, Dalia Abd, Alkady, Radwa Salaheldin, El Sayed El Hawary, Rabab, Eldash, Alia S., Galal, Nermeen, Lotfy, Sohilla, Meshaal, Safa S., Reda, Shereen M., Sobh, Ali, Elmarsafy, Aisha, Seppänen, Mikko R.J., Brosselin, Pauline, Courteille, Virginie, De Vergnes, Nathalie, Kracker, Sven, Pergent, Martine, Randrianomenjanahary, Philippe, Ahrenstorf, Gerrit, Albert, Michael H., Ankermann, Tobias, Atschekzei, Faranaz, Baumann, Ulrich, Becker, Benjamin C., Behrends, Uta, Belohradsky, Bernd H., Biegner, Anika-Kerstin, Binder, Nadine, Bode, Sebastian F.N., Boesecke, Christoph, Boetticher, Benedikt, Borte, Michael, Borte, Stephan, Classen, Carl Friedrich, Dirks, Johannes, Dückers, Gregor, El-Helou, Sabine, Ernst, Diana, Fasshauer, Maria, Fecker, Gisela, Felgentreff, Kerstin, Foell, Dirk, Ghosh, Sujal, Girschick, Hermann J., Goldacker, Sigune, Graf, Norbert, Graf, Dagmar, Greil, Johann, Hanitsch, Leif Gunnar, Hauck, Fabian, Heeg, Maximilian, Heine, Sabine I., Henes, Joerg C., Hoenig, Manfred, Holzer, Ursula, Holzinger, Dirk, Horneff, Gerd, Hundsdoerfer, Patrick, Jablonka, Alexandra, Jakoby, Donate, Joean, Oana, Kaiser-Labusch, Petra, Klemann, Christian, Kobbe, Robin, Körholz, Julia, Kramm, Christof M., Krüger, Renate, Landwehr-Kenzel, Sybille, Lehmberg, Kai, Liese, Johannes G., Lippert, Conrad Ferdinand, Maccari, Maria Elena, Masjosthusmann, Katja, Meinhardt, Andrea, Metzler, Markus, Morbach, Henner, Müller, Ingo, Naumann-Bartsch, Nora, Neubert, Jennifer, Niehues, Tim, Peter, Hans-Hartmut, Rieber, Nikolaus, Ritterbusch, Henrike, Rockstroh, Jürgen Kurt, Roesler, Joachim, Schauer, Uwe, Scheible, Raphael, Schmalzing, Marc, Schmidt, Reinhold Ernst, Schneider, Dominik T., Schreiber, Stefan, Schuetz, Catharina, Schulz, Ansgar, Schulze-Koops, Hendrik, Schulze-Sturm, Ulf, Schuster, Volker, Schwaneck, Eva C., Schwarz, Klaus, Schwarze-Zander, Carolynne, Sirin, Mehtap, Skapenko, Alla, Sogkas, Georgios, Sparber-Sauer, Monika, Speckmann, Carsten, Steinmann, Sandra, Stiehler, Sophie, Tenbrock, Klaus, von Bernuth, Horst, Warnatz, Klaus, Wasmuth, Jan-Christian, Weiss, Michael, Witte, Torsten, Wittke, Kirsten, Wittkowski, Helmut, Zeuner, Rainald A., Farmaki, Evangelia, Hatzistilianou, Maria N., Kakkas, Ioannis, Kanariou, Maria G., Kapousouzi, Androniki, Liatsis, Emmanouil, Maggina, Paraskevi, Papadopoulou-Alataki, Efimia, Raptaki, Maria, Speletas, Matthaios, Tantou, Sofia, Goda, Vera, Kriván, Gergely, Marodi, Laszlo, Abolhassani, Hassan, Aghamohammadi, Asghar, Rezaei, Nima, Feighery, Conleth, Leahy, Timothy Ronan, Ryan, Paul, Batzir, Nurit Assia, Garty, Ben Zion, Tamary, Hannah, Aiuti, Alessandro, Amodio, Donato, Azzari, Chiara, Barzaghi, Federica, Baselli, Lucia A., Cancrini, Caterina, Carrabba, Maria, Cazzaniga, Marco, Cesaro, Simone, Chinello, Matteo, Danieli, Maria Giovanna, Dellepiane, Rosa Maria, Fabio, Giovanna, Gambineri, Eleonora, Lodi, Lorenzo, Lougaris, Vassilios, Marasco, Carolina, Martire, Baldassarre, Marzollo, Antonio, Milito, Cinzia, Moschese, Viviana, Pignata, Claudio, Plebani, Alessandro, Porta, Fulvio, Quinti, Isabella, Ricci, Silvia, Soresina, Annarosa, Tommasini, Alberto, Vacca, Angelo, Vanessa, Clementina, Blažienė, Audra, Sitkauskiene, Brigita, Gowin, Ewelina, Heropolitańska-Pliszka, Edyta, Pietrucha, Barbara, Szaflarska, Anna, Więsik-Szewczyk, Ewa, Wolska-Kuśnierz, Beata, Esteves, Isabel, Faria, Emilia, Marques, Laura Hora, Neves, João Farela, Silva, Susana L., Teixeira, Carla, Pereira da Silva, Sara, Capilna, Brindusa Ruxandra, Guseva, Marina N., Shcherbina, Anna, Bobcakova, Anna, Ciznar, Peter, Gabzdilova, Juliana, Jesenak, Milos, Kapustova, Lenka, Orosova, Jaroslava, Petrovicova, Otilia, Raffac, Stefan, Kopač, Peter, Allende, Luis M., Antolí, Arnau, Blanch, Gemma Rocamora, Carbone, Javier, Dieli-Crimi, Romina, Garcia-Prat, Marina, Gil-Herrera, Juana, Gonzalez-Granado, Luis Ignacio, Agulló, Pilar Llobet, Olbrich, Peter, Parra-Martínez, Alba, Paz-Artal, Estela, Pleguezuelo, Daniel E., Rodríguez, Nerea Salmón, Sánchez-Ramón, Silvia, Santos-Pérez, Juan Luis, Solanich, Xavier, Soler-Palacin, Pere, González-Amores, Miriam, Ekwall, Olov, Fasth, Anders, Bitzenhofer-Grüber, Michaela, Candotti, Fabio, Dimitriou, Florentia, Heininger, Ulrich, Holbro, Andreas, Jandus, Peter, Kolios, Antonios G.A., Marschall, Karin, Schmid, Jana Pachlopnik, Posfay-Barbe, Klara M., Prader, Seraina, Reichenbach, Janine, Steiner, Urs C., Trück, Johannes, Bredius, Robbert G., de Kruijf- Bazen, Suzanne, de Vries, Esther, Henriet, Stefanie S.V., Kuijpers, Taco W., Potjewijd, Judith, Rutgers, Abraham, Stol, Kim, van Aerde, Koen J., Van den Berg, J. Merlijn, van de Ven, Annick A.J.M., Montfrans, Jorisvan, Aydemir, Sezin, Baris, Safa, Dogu, Figen, Ikinciogullari, Aydan, Karakoc-Aydiner, Elif, Kilic, Sara S., Kiykim, Ayca, Kökçü Karadağ, Şefika İlknur, Kutukculer, Necil, Ocak, Suheyla, UNAL, Ekrem, Boyarchuk, Oksana, Hilfanova, Anna, Kostyuchenko, Larysa V., Alachkar, Hana, Arkwright, Peter D., Baxendale, Helen E., Bernatoniene, Jolanta, Coulter, Tanya I., Garcez, Tomaz, Goddard, Sarah, Gompels, Mark M., Grigoriadou, Sofia, Herriot, Richard, Herwadkar, Archana, Huissoon, Aarnoud, Ibberson, Lisa, Nademi, Zoreh, Noorani, Sadia, Parvin, Shahnaz, Steele, Cathal Laurence, Thomas, Moira, Waruiru, Catherine, Yong, Patrick F.K., Bourne, Helen, Thalhammer, Julian, Kindle, Gerhard, Nieters, Alexandra, Rusch, Stephan, Fischer, Alain, Grimbacher, Bodo, Edgar, David, Buckland, Matthew, Mahlaoui, Nizar, and Ehl, Stephan

Published
2021
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18. PATZ1 fusions define a novel molecularly distinct neuroepithelial tumor entity with a broad histological spectrum

Author

Alhalabi, Karam T., Stichel, Damian, Sievers, Philipp, Peterziel, Heike, Sommerkamp, Alexander C., Sturm, Dominik, Wittmann, Andrea, Sill, Martin, Jäger, Natalie, Beck, Pengbo, Pajtler, Kristian W., Snuderl, Matija, Jour, George, Delorenzo, Michael, Martin, Allison M., Levy, Adam, Dalvi, Nagma, Hansford, Jordan R., Gottardo, Nicholas G., Uro-Coste, Emmanuelle, Maurage, Claude-Alain, Godfraind, Catherine, Vandenbos, Fanny, Pietsch, Torsten, Kramm, Christof, Filippidou, Maria, Kattamis, Antonis, Jones, Chris, Øra, Ingrid, Mikkelsen, Torben Stamm, Zapotocky, Michal, Sumerauer, David, Scheie, David, McCabe, Martin, Wesseling, Pieter, Tops, Bastiaan B. J., Kranendonk, Mariëtte E. G., Karajannis, Matthias A., Bouvier, Nancy, Papaemmanuil, Elli, Dohmen, Hildegard, Acker, Till, von Hoff, Katja, Schmid, Simone, Miele, Evelina, Filipski, Katharina, Kitanovski, Lidija, Krskova, Lenka, Gojo, Johannes, Haberler, Christine, Alvaro, Frank, Ecker, Jonas, Selt, Florian, Milde, Till, Witt, Olaf, Oehme, Ina, Kool, Marcel, von Deimling, Andreas, Korshunov, Andrey, Pfister, Stefan M., Sahm, Felix, and Jones, David T. W.

Published
2021
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19. Primary mismatch repair deficient IDH-mutant astrocytoma (PMMRDIA) is a distinct type with a poor prognosis

Author

Suwala, Abigail K., Stichel, Damian, Schrimpf, Daniel, Kloor, Matthias, Wefers, Annika K., Reinhardt, Annekathrin, Maas, Sybren L. N., Kratz, Christian P., Schweizer, Leonille, Hasselblatt, Martin, Snuderl, Matija, Abedalthagafi, Malak Sameer J., Abdullaev, Zied, Monoranu, Camelia M., Bergmann, Markus, Pekrun, Arnulf, Freyschlag, Christian, Aronica, Eleonora, Kramm, Christof M., Hinz, Felix, Sievers, Philipp, Korshunov, Andrey, Kool, Marcel, Pfister, Stefan M., Sturm, Dominik, Jones, David T. W., Wick, Wolfgang, Unterberg, Andreas, Hartmann, Christian, Dodgshun, Andrew, Tabori, Uri, Wesseling, Pieter, Sahm, Felix, von Deimling, Andreas, and Reuss, David E.

Published
2021
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20. New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs.

Author

Sturm, Dominik, Orr, Brent A, Toprak, Umut H, Hovestadt, Volker, Jones, David TW, Capper, David, Sill, Martin, Buchhalter, Ivo, Northcott, Paul A, Leis, Irina, Ryzhova, Marina, Koelsche, Christian, Pfaff, Elke, Allen, Sariah J, Balasubramanian, Gnanaprakash, Worst, Barbara C, Pajtler, Kristian W, Brabetz, Sebastian, Johann, Pascal D, Sahm, Felix, Reimand, Jüri, Mackay, Alan, Carvalho, Diana M, Remke, Marc, Phillips, Joanna J, Perry, Arie, Cowdrey, Cynthia, Drissi, Rachid, Fouladi, Maryam, Giangaspero, Felice, Łastowska, Maria, Grajkowska, Wiesława, Scheurlen, Wolfram, Pietsch, Torsten, Hagel, Christian, Gojo, Johannes, Lötsch, Daniela, Berger, Walter, Slavc, Irene, Haberler, Christine, Jouvet, Anne, Holm, Stefan, Hofer, Silvia, Prinz, Marco, Keohane, Catherine, Fried, Iris, Mawrin, Christian, Scheie, David, Mobley, Bret C, Schniederjan, Matthew J, Santi, Mariarita, Buccoliero, Anna M, Dahiya, Sonika, Kramm, Christof M, von Bueren, André O, von Hoff, Katja, Rutkowski, Stefan, Herold-Mende, Christel, Frühwald, Michael C, Milde, Till, Hasselblatt, Martin, Wesseling, Pieter, Rößler, Jochen, Schüller, Ulrich, Ebinger, Martin, Schittenhelm, Jens, Frank, Stephan, Grobholz, Rainer, Vajtai, Istvan, Hans, Volkmar, Schneppenheim, Reinhard, Zitterbart, Karel, Collins, V Peter, Aronica, Eleonora, Varlet, Pascale, Puget, Stephanie, Dufour, Christelle, Grill, Jacques, Figarella-Branger, Dominique, Wolter, Marietta, Schuhmann, Martin U, Shalaby, Tarek, Grotzer, Michael, van Meter, Timothy, Monoranu, Camelia-Maria, Felsberg, Jörg, Reifenberger, Guido, Snuderl, Matija, Forrester, Lynn Ann, Koster, Jan, Versteeg, Rogier, Volckmann, Richard, van Sluis, Peter, Wolf, Stephan, Mikkelsen, Tom, Gajjar, Amar, Aldape, Kenneth, Moore, Andrew S, Taylor, Michael D, and Jones, Chris

Subjects
Humans, Neuroectodermal Tumors, Central Nervous System Neoplasms, Trans-Activators, Proto-Oncogene Proteins, Tumor Suppressor Proteins, Repressor Proteins, Gene Expression Profiling, Signal Transduction, DNA Methylation, Gene Expression Regulation, Neoplastic, Amino Acid Sequence, Molecular Sequence Data, Child, Forkhead Transcription Factors, Neuroblastoma, Cancer, Pediatric, Neurosciences, Brain Disorders, Rare Diseases, Orphan Drug, Brain Cancer, Pediatric Research Initiative, Pediatric Cancer, Biological Sciences, Medical and Health Sciences, Developmental Biology
Abstract

Primitive neuroectodermal tumors of the central nervous system (CNS-PNETs) are highly aggressive, poorly differentiated embryonal tumors occurring predominantly in young children but also affecting adolescents and adults. Herein, we demonstrate that a significant proportion of institutionally diagnosed CNS-PNETs display molecular profiles indistinguishable from those of various other well-defined CNS tumor entities, facilitating diagnosis and appropriate therapy for patients with these tumors. From the remaining fraction of CNS-PNETs, we identify four new CNS tumor entities, each associated with a recurrent genetic alteration and distinct histopathological and clinical features. These new molecular entities, designated "CNS neuroblastoma with FOXR2 activation (CNS NB-FOXR2)," "CNS Ewing sarcoma family tumor with CIC alteration (CNS EFT-CIC)," "CNS high-grade neuroepithelial tumor with MN1 alteration (CNS HGNET-MN1)," and "CNS high-grade neuroepithelial tumor with BCOR alteration (CNS HGNET-BCOR)," will enable meaningful clinical trials and the development of therapeutic strategies for patients affected by poorly differentiated CNS tumors.

Published
2016

21. European Cancer Organisation Essential Requirements for Quality Cancer Care: Adult glioma

Author

Bozzao, Alessandro, primary, Weber, Damien, additional, Crompton, Simon, additional, Braz, Graça, additional, Csaba, Dégi, additional, Dhermain, Frederic, additional, Finocchiaro, Gaetano, additional, Flannery, Thomas, additional, Kramm, Christof, additional, Law, Ian, additional, Marucci, Gianluca, additional, Oliver, Kathy, additional, Ostgathe, Christoph, additional, Paterra, Rosina, additional, Pesce, Gianfranco, additional, Smits, Marion, additional, Soffietti, Riccardo, additional, Terkola, Robert, additional, Watts, Colin, additional, Costa, Alberto, additional, and Poortmans, Philip, additional

Published
2023
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22. Radiation-induced gliomas represent H3-/IDH-wild type pediatric gliomas with recurrent PDGFRA amplification and loss of CDKN2A/B

Author

Deng, Maximilian Y., Sturm, Dominik, Pfaff, Elke, Sill, Martin, Stichel, Damian, Balasubramanian, Gnana Prakash, Tippelt, Stephan, Kramm, Christof, Donson, Andrew M., Green, Adam L., Jones, Chris, Schittenhelm, Jens, Ebinger, Martin, Schuhmann, Martin U., Jones, Barbara C., van Tilburg, Cornelis M., Wittmann, Andrea, Golanov, Andrey, Ryzhova, Marina, Ecker, Jonas, Milde, Till, Witt, Olaf, Sahm, Felix, Reuss, David, Sumerauer, David, Zamecnik, Josef, Korshunov, Andrey, von Deimling, Andreas, Pfister, Stefan M., and Jones, David T. W.

Published
2021
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25. Genotyping circulating tumor DNA of pediatric Hodgkin lymphoma

Author

Desch, Ann-Kathrin, Hartung, Kristin, Botzen, Ante, Brobeil, Alexander, Rummel, Mathias, Kurch, Lars, Georgi, Thomas, Jox, Theresa, Bielack, Stefan, Burdach, Stefan, Classen, Carl Friedrich, Claviez, Alexander, Debatin, Klaus-Michael, Ebinger, Martin, Eggert, Angelika, Faber, Jörg, Flotho, Christian, Frühwald, Michael, Graf, Norbert, Jorch, Norbert, Kontny, Udo, Kramm, Christof, Kulozik, Andreas, Kühr, Joachim, Sykora, Karl-Walter, Metzler, Markus, Müller, Hermann L., Nathrath, Michaela, Nüßlein, Thomas, Paulussen, Michael, Pekrun, Arnulf, Reinhardt, Dirk, Reinhard, Harald, Rössig, Claudia, Sauerbrey, Axel, Schlegel, Paul-Gerhardt, Schneider, Dominik T., Scheurlen, Wolfram, Schweigerer, Lothar, Simon, Thorsten, Suttorp, Meinolf, Vorwerk, Peter, Schmitz, Roland, Kluge, Regine, Mauz-Körholz, Christine, Körholz, Dieter, Gattenlöhner, Stefan, and Bräuninger, Andreas

Published
2020
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26. Identification of amino acid determinants in CYP4B1 for optimal catalytic processing of 4-ipomeanol.

Author

Wiek, Constanze, Schmidt, Eva M, Roellecke, Katharina, Freund, Marcel, Nakano, Mariko, Kelly, Edward J, Kaisers, Wolfgang, Yarov-Yarovoy, Vladimir, Kramm, Christof M, Rettie, Allan E, and Hanenberg, Helmut

Subjects
Biotechnology, Animals, Aryl Hydrocarbon Hydroxylases, Biocatalysis, Enzyme Stability, Genes, Transgenic, Suicide, HEK293 Cells, Hep G2 Cells, Humans, Proline, Protein Engineering, Rabbits, Structure-Activity Relationship, T-Lymphocytes, Terpenes, cytochrome P450 4B1, 4-ipomeanol, suicide gene system, Chemical Sciences, Biological Sciences, Medical and Health Sciences, Biochemistry & Molecular Biology
Abstract

Mammalian CYP4B1 enzymes are cytochrome P450 mono-oxygenases that are responsible for the bioactivation of several exogenous pro-toxins including 4-ipomeanol (4-IPO). In contrast with the orthologous rabbit enzyme, we show here that native human CYP4B1 with a serine residue at position 427 is unable to bioactivate 4-IPO and does not cause cytotoxicity in HepG2 cells and primary human T-cells that overexpress these enzymes. We also demonstrate that a proline residue in the meander region at position 427 in human CYP4B1 and 422 in rabbit CYP4B1 is important for protein stability and rescues the 4-IPO bioactivation of the human enzyme, but is not essential for the catalytic activity of the rabbit CYP4B1 protein. Systematic substitution of native and p.S427P human CYP4B1 with peptide regions from the highly active rabbit enzyme reveals that 18 amino acids in the wild-type rabbit CYP4B1 protein are key for conferring high 4-IPO metabolizing activity. Introduction of 12 of the 18 amino acids that are also present at corresponding positions in other human CYP4 family members into the p.S427P human CYP4B1 protein results in a mutant human enzyme (P+12) that is as stable and as active as the rabbit wild-type CYP4B1 protein. These 12 mutations cluster in the predicted B-C loop through F-helix regions and reveal new amino acid regions important to P450 enzyme stability. Finally, by minimally re-engineering the human CYP4B1 enzyme for efficient activation of 4-IPO, we have developed a novel human suicide gene system that is a candidate for adoptive cellular therapies in humans.

Published
2015

27. Characterization of an Additional Splice Acceptor Site Introduced into CYP4B1 in Hominoidae during Evolution.

Author

Schmidt, Eva M, Wiek, Constanze, Parkinson, Oliver T, Roellecke, Katharina, Freund, Marcel, Gombert, Michael, Lottmann, Nadine, Steward, Charles A, Kramm, Christof M, Yarov-Yarovoy, Vladimir, Rettie, Allan E, and Hanenberg, Helmut

Subjects
Animals, Rabbits, Humans, Terpenes, Aryl Hydrocarbon Hydroxylases, Serine, RNA Splice Sites, Mutagenesis, Insertional, Enzyme Stability, Cell Death, Alternative Splicing, Models, Molecular, Adult, Hep G2 Cells, Biological Evolution, HEK293 Cells, General Science & Technology
Abstract

CYP4B1 belongs to the cytochrome P450 family 4, one of the oldest P450 families whose members have been highly conserved throughout evolution. The CYP4 monooxygenases typically oxidize fatty acids to both inactive and active lipid mediators, although the endogenous ligand(s) is largely unknown. During evolution, at the transition of great apes to humanoids, the CYP4B1 protein acquired a serine instead of a proline at the canonical position 427 in the meander region. Although this alteration impairs P450 function related to the processing of naturally occurring lung toxins, a study in transgenic mice suggested that an additional serine insertion at position 207 in human CYP4B1 can rescue the enzyme stability and activity. Here, we report that the genomic insertion of a CAG triplet at the intron 5-exon 6 boundary in human CYP4B1 introduced an additional splice acceptor site in frame. During evolution, this change occurred presumably at the stage of Hominoidae and leads to two major isoforms of the CYP4B1 enzymes of humans and great apes, either with or without a serine 207 insertion (insSer207). We further demonstrated that the CYP4B1 enzyme with insSer207 is the dominant isoform (76%) in humans. Importantly, this amino acid insertion did not affect the 4-ipomeanol metabolizing activities or stabilities of the native rabbit or human CYP4B1 enzymes, when introduced as transgenes in human primary cells and cell lines. In our 3D modeling, this functional neutrality of insSer207 is compatible with its predicted location on the exterior surface of CYP4B1 in a flexible side chain. Therefore, the Ser207 insertion does not rescue the P450 functional activity of human CYP4B1 that has been lost during evolution.

Published
2015

29. DDDR-17. CLINICAL RESPONSE TO THE PDGFRA/KIT INHIBITOR AVAPRITINIB IN PEDIATRIC AND YOUNG ADULT HIGH-GRADE GLIOMA PATIENTS

Author

Mayr, Lisa, primary, Trissal, Maria, additional, Schwark, Kallen, additional, Neyazi, Sina, additional, Beck, Alexander, additional, Labelle, Jenna, additional, Marques, Joana Graca, additional, Weiler-Wichtl, Liesa, additional, Madlener, Sibylle, additional, Kong, Seongbae, additional, Miclea, Madeline, additional, Supko, Jeffrey, additional, Guntner, Armin Sebastian, additional, Palova, Hana, additional, Neradil, Jakub, additional, Stepien, Natalia, additional, Loetsch-Gojo, Daniela, additional, Dorfer, Christian, additional, Dieckmann, Karen, additional, Peyrl, Andreas, additional, Azizi, Amedeo A, additional, Baumgartner, Alicia-Christina, additional, Slaby, Ondrej, additional, Pokorna, Petra, additional, Dubois, Frank, additional, Greenwald, Noah, additional, Bandopadhayay, Pratiti, additional, Beroukhim, Rameen, additional, Ligon, Keith, additional, Kramm, Christof, additional, Bronsema, Annika, additional, Bailey, Simon, additional, Stuecklin, Ana Guerreiro, additional, Mueller, Sabine, additional, Skrypek, Mary, additional, Martinez, Nina, additional, Bowers, Daniel C, additional, Jones, David, additional, Jones, Chris, additional, Jaeger, Natalie, additional, Sterba, Jaroslav, additional, Müllauer, Leonhard, additional, Haberler, Christine, additional, Kumar-Sinha, Chandan, additional, Chinnaiyan, Arul, additional, Mody, Rajen, additional, Furtner-Srajer, Julia, additional, Koschmann, Carl, additional, Gojo, Johannes, additional, and Filbin, Mariella, additional

Published
2023
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30. Author Correction: Multiomic neuropathology improves diagnostic accuracy in pediatric neuro-oncology

Author

Sturm, Dominik, primary, Capper, David, additional, Andreiuolo, Felipe, additional, Gessi, Marco, additional, Kölsche, Christian, additional, Reinhardt, Annekathrin, additional, Sievers, Philipp, additional, Wefers, Annika K., additional, Ebrahimi, Azadeh, additional, Suwala, Abigail K., additional, Gielen, Gerrit H., additional, Sill, Martin, additional, Schrimpf, Daniel, additional, Stichel, Damian, additional, Hovestadt, Volker, additional, Daenekas, Bjarne, additional, Rode, Agata, additional, Hamelmann, Stefan, additional, Previti, Christopher, additional, Jäger, Natalie, additional, Buchhalter, Ivo, additional, Blattner-Johnson, Mirjam, additional, Jones, Barbara C., additional, Warmuth-Metz, Monika, additional, Bison, Brigitte, additional, Grund, Kerstin, additional, Sutter, Christian, additional, Hirsch, Steffen, additional, Dikow, Nicola, additional, Hasselblatt, Martin, additional, Schüller, Ulrich, additional, Koch, Arend, additional, Gerber, Nicolas U., additional, White, Christine L., additional, Buntine, Molly K., additional, Kinross, Kathryn, additional, Algar, Elizabeth M., additional, Hansford, Jordan R., additional, Gottardo, Nicholas G., additional, Schuhmann, Martin U., additional, Thomale, Ulrich W., additional, Hernáiz Driever, Pablo, additional, Gnekow, Astrid, additional, Witt, Olaf, additional, Müller, Hermann L., additional, Calaminus, Gabriele, additional, Fleischhack, Gudrun, additional, Kordes, Uwe, additional, Mynarek, Martin, additional, Rutkowski, Stefan, additional, Frühwald, Michael C., additional, Kramm, Christof M., additional, von Deimling, Andreas, additional, Pietsch, Torsten, additional, Sahm, Felix, additional, Pfister, Stefan M., additional, and Jones, David. T. W., additional

Published
2023
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31. High-grade Glioma

Author

Macarthur, Donald C., primary, Kramm, Christof M., additional, and Karajannis, Matthias A., additional

Published
2020
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32. Diagnostics and treatment of diffuse intrinsic pontine glioma: where do we stand?

Author

El-Khouly, Fatma E., Veldhuijzen van Zanten, Sophie E. M., Santa-Maria Lopez, Vicente, Hendrikse, N. Harry, Kaspers, Gertjan J. L., Loizos, G., Sumerauer, David, Nysom, Karsten, Pruunsild, Kaie, Pentikainen, Virve, Thorarinsdottir, Halldora K., Rutkauskiene, Giedre, Calvagna, Victor, Drogosiewicz, Monika, Dragomir, Monica, Deak, Ladislav, Kitanovski, Lidija, von Bueren, Andre O., Kebudi, Rejin, Slavc, Irene, Jacobs, Sandra, Jadrijevic-Cvrlje, Filip, Entz-Werle, Natacha, Grill, Jacques, Kattamis, Antonis, Hauser, Peter, Pears, Jane, Biassoni, Veronica, Massimino, Maura, Lopez Aguilar, Enrique, Torsvik, Ingrid K., Joao Gil-da-Costa, Maria, Kumirova, Ella, Cruz-Martinez, Ofelia, Holm, Stefan, Bailey, Simon, Hayden, Tim, Thomale, Ulrich W., Janssens, Geert O. R., Kramm, Christof M., and van Vuurden, Dannis G.

Published
2019
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33. HGG-19. CLINICAL RESPONSE TO THE PDGFRA/KIT INHIBITOR AVAPRITINIB IN PEDIATRIC AND YOUNG ADULT HIGH-GRADE GLIOMA PATIENTS WITH H3K27M OR PDGFRA GENOMIC ALTERATIONS

Author

Trissal, Maria, primary, Mayr, Lisa, additional, Schwark, Kallen, additional, LaBelle, Jenna, additional, Kong, Seongbae, additional, Furtner, Julia, additional, Weiler-Wichtl, Liesa, additional, Supko, Jeffrey, additional, Rozowsky, Jacob, additional, Hack, Olivia, additional, Groves, Andrew, additional, Marques, Joana, additional, Leiss, Ulrike, additional, Rosenmayr, Verena, additional, Dubois, Frank, additional, Greenwald, Noah F, additional, Madlener, Sibylle, additional, Guntner, Armin Sebastian, additional, Pálová, Hana, additional, Stepien, Natalia, additional, Lötsch-Gojo, Daniela, additional, Dorfer, Christian, additional, Dieckmann, Karen, additional, Peyrl, Andreas, additional, Azizi, Amadeo A, additional, Baumgartner, Alicia, additional, Slabý, Ondřej, additional, Pokorná, Petra, additional, Bandopadhayay, Pratiti, additional, Rameen_Beroukhim@dfci.harvard.edu Beroukhim, Rameen Beroukhim, additional, Ligon, Keith L, additional, Kramm, Christof M, additional, Bronsema, Annika, additional, Bailey, Simon, additional, Stucklin, Ana Guerreiro, additional, Mueller, Sabine Mueller, additional, Jones, David T W, additional, Jäger, Natalie, additional, Mullauer, Leonhard, additional, Haberler, Christine, additional, Kumar-Sinha, Chandan, additional, Chinnaiyan, Arul, additional, Mody, Rajen, additional, Sterba.Jaroslav@fnbrno.cz Štěrba, Jaroslav Štěrba, additional, Skrypek, Mary, additional, Martinez, Nina, additional, Bowers, Daniel C, additional, Koschmann, Carl Koschmann, additional, Gojo, Johannes, additional, and Filbin, Mariella, additional

Published
2023
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35. Survival benefit for patients with diffuse intrinsic pontine glioma (DIPG) undergoing re-irradiation at first progression: A matched-cohort analysis on behalf of the SIOP-E-HGG/DIPG working group

Author

Janssens, Geert O., Gandola, Lorenza, Bolle, Stephanie, Mandeville, Henry, Ramos-Albiac, Monica, van Beek, Karen, Benghiat, Helen, Hoeben, Bianca, Morales La Madrid, Andres, Kortmann, Rolf-Dieter, Hargrave, Darren, Menten, Johan, Pecori, Emilia, Biassoni, Veronica, von Bueren, Andre O., van Vuurden, Dannis G., Massimino, Maura, Sturm, Dominik, Peters, Max, and Kramm, Christof M.

Published
2017
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38. Optimizing the structure of interdisciplinary tumor boards for effective cancer care

Author

Braulke, Friederike, primary, Kober, Kathrin, additional, Arndt, Andreas, additional, Papendick, Maximilian, additional, Strauss, Arne, additional, Kramm, Christof Maria, additional, Thoms, Kai-Martin, additional, König, Alexander, additional, Gaedcke, Jochen, additional, Gallwas, Julia, additional, Wulf, Svenja, additional, Szuszies, Christoph, additional, Wulf, Gerald, additional, Rödel, Ralph, additional, Wolfer, Susanne, additional, Malinova, Vesna, additional, Overbeck, Tobias R., additional, Hinterthaner, Marc, additional, Lotz, Joachim, additional, Nauck, Friedemann, additional, Ernst, Marielle, additional, Stadelmann, Christine, additional, Ströbel, Philipp, additional, Ellenrieder, Volker, additional, Asendorf, Thomas, additional, and Rieken, Stefan, additional

Published
2023
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39. Abstract 5719: Clinical response to the PDGFRα inhibitor avapritinib in high-grade glioma patients

Author

Mayr, Lisa, primary, Trissal, Maria, additional, Schwark, Kallen, additional, Labelle, Jenna, additional, Groves, Andrew, additional, Furtner-Srajer, Julia, additional, Supko, Jeffrey, additional, Weiler-Wichtl, Liesa, additional, Hack, Olivia, additional, Rozowsky, Jacob, additional, Marques, Joana G., additional, Pandatharatna, Eshini, additional, Leiss, Ulrike, additional, Rosenmayr, Verena, additional, Dubois, Frank, additional, Greenwald, Noah F., additional, Madlener, Sibylle, additional, Guntner, Armin S., additional, Pálová, Hana, additional, Stepien, Natalia, additional, Lötsch-Gojo, Daniela, additional, Dorfer, Christian, additional, Dieckmann, Karin, additional, Peyrl, Andreas, additional, Azizi, Amedeo A., additional, Baumgartner, Alicia, additional, Slabý, Ondřej, additional, Pokorná, Petra, additional, Bandopadhayay, Pratiti, additional, Beroukhim, Rameen, additional, Ligon, Keith, additional, Kramm, Christof, additional, Bronsema, Annika, additional, Bailey, Simon, additional, Stücklin, Ana Guerreiro, additional, Mueller, Sabine, additional, Jones, David T., additional, Jäger, Natalie, additional, Štěrba, Jaroslav, additional, Müllauer, Leonhard, additional, Haberler, Christine, additional, Kumar-Sinha, Chandan, additional, Chinnaiyan, Arul, additional, Mody, Rajen, additional, Skrypek, Mary, additional, Martinez, Nina, additional, Bowers, Daniel C., additional, Koschmann, Carl, additional, Gojo, Johannes, additional, and Filbin, Mariella, additional

Published
2023
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40. Abstract 3562: Dissecting mechanisms underlying FOXR2-mediated gliomagenesis in diffuse midline gliomas

Author

Tsai, Jessica W., primary, Cejas, Paloma, additional, Coppola, Marissa, additional, Wang, Dayle K., additional, Patel, Smruti, additional, Wu, David W., additional, Arounleut, Phonepasong, additional, Wei, Xin, additional, Zhou, Ningxuan, additional, Syamala, Sudeepa, additional, Dubois, Frank P., additional, Pelton, Kristine, additional, Vogelzang, Jayne, additional, Sousa, Cecilia, additional, Baguette, Audrey, additional, Chen, Xiaolong, additional, Condurat, Alexandra L., additional, Dixon-Clarke, Sarah E., additional, Charles, Annarah, additional, Zhou, Kevin N., additional, Lu, Sophie D., additional, Gonzalez, Elizabeth M., additional, Chacon, Madison S., additional, Digiacomo, Jeromy J., additional, Kumbhani, Rushil, additional, Novikov, Dana, additional, Tsoli, Maria, additional, Ziegler, David S., additional, Dirksen, Uta, additional, Jager, Natalie, additional, Balasubramanian, Gnana Prakash, additional, Kramm, Christof M., additional, Nathrath, Michaela, additional, Bielack, Stefan, additional, Baker, Suzanne J., additional, Zhang, Jinghui, additional, McFarland, James M., additional, Getz, Gad, additional, Aguet, Francois, additional, Jabado, Nada, additional, Witt, Olaf, additional, Pfister, Stefan M., additional, Ligon, Keith L., additional, Hovestadt, Volker, additional, Kleinman, Claudia, additional, Long, Henry, additional, Jones, David T., additional, Bandopadhayay, Pratiti, additional, and Phoenix, Timothy N., additional

Published
2023
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41. Data from Infant High-Grade Gliomas Comprise Multiple Subgroups Characterized by Novel Targetable Gene Fusions and Favorable Outcomes

Author

Clarke, Matthew, primary, Mackay, Alan, primary, Ismer, Britta, primary, Pickles, Jessica C., primary, Tatevossian, Ruth G., primary, Newman, Scott, primary, Bale, Tejus A., primary, Stoler, Iris, primary, Izquierdo, Elisa, primary, Temelso, Sara, primary, Carvalho, Diana M., primary, Molinari, Valeria, primary, Burford, Anna, primary, Howell, Louise, primary, Virasami, Alex, primary, Fairchild, Amy R., primary, Avery, Aimee, primary, Chalker, Jane, primary, Kristiansen, Mark, primary, Haupfear, Kelly, primary, Dalton, James D., primary, Orisme, Wilda, primary, Wen, Ji, primary, Hubank, Michael, primary, Kurian, Kathreena M., primary, Rowe, Catherine, primary, Maybury, Mellissa, primary, Crosier, Stephen, primary, Knipstein, Jeffrey, primary, Schüller, Ulrich, primary, Kordes, Uwe, primary, Kram, David E., primary, Snuderl, Matija, primary, Bridges, Leslie, primary, Martin, Andrew J., primary, Doey, Lawrence J., primary, Al-Sarraj, Safa, primary, Chandler, Christopher, primary, Zebian, Bassel, primary, Cairns, Claire, primary, Natrajan, Rachael, primary, Boult, Jessica K.R., primary, Robinson, Simon P., primary, Sill, Martin, primary, Dunkel, Ira J., primary, Gilheeney, Stephen W., primary, Rosenblum, Marc K., primary, Hughes, Debbie, primary, Proszek, Paula Z., primary, Macdonald, Tobey J., primary, Preusser, Matthias, primary, Haberler, Christine, primary, Slavc, Irene, primary, Packer, Roger, primary, Ng, Ho-Keung, primary, Caspi, Shani, primary, Popović, Mara, primary, Faganel Kotnik, Barbara, primary, Wood, Matthew D., primary, Baird, Lissa, primary, Davare, Monika Ashok, primary, Solomon, David A., primary, Olsen, Thale Kristin, primary, Brandal, Petter, primary, Farrell, Michael, primary, Cryan, Jane B., primary, Capra, Michael, primary, Karremann, Michael, primary, Schittenhelm, Jens, primary, Schuhmann, Martin U., primary, Ebinger, Martin, primary, Dinjens, Winand N.M., primary, Kerl, Kornelius, primary, Hettmer, Simone, primary, Pietsch, Torsten, primary, Andreiuolo, Felipe, primary, Driever, Pablo Hernáiz, primary, Korshunov, Andrey, primary, Hiddingh, Lotte, primary, Worst, Barbara C., primary, Sturm, Dominik, primary, Zuckermann, Marc, primary, Witt, Olaf, primary, Bloom, Tabitha, primary, Mitchell, Clare, primary, Miele, Evelina, primary, Colafati, Giovanna Stefania, primary, Diomedi-Camassei, Francesca, primary, Bailey, Simon, primary, Moore, Andrew S., primary, Hassall, Timothy E.G., primary, Lowis, Stephen P., primary, Tsoli, Maria, primary, Cowley, Mark J., primary, Ziegler, David S., primary, Karajannis, Matthias A., primary, Aquilina, Kristian, primary, Hargrave, Darren R., primary, Carceller, Fernando, primary, Marshall, Lynley V., primary, von Deimling, Andreas, primary, Kramm, Christof M., primary, Pfister, Stefan M., primary, Sahm, Felix, primary, Baker, Suzanne J., primary, Mastronuzzi, Angela, primary, Carai, Andrea, primary, Vinci, Maria, primary, Capper, David, primary, Popov, Sergey, primary, Ellison, David W., primary, Jacques, Thomas S., primary, Jones, David T.W., primary, and Jones, Chris, primary

Published
2023
Full Text
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42. Supplementary Table from The Pediatric Precision Oncology INFORM Registry: Clinical Outcome and Benefit for Patients with Very High-Evidence Targets

Author

van Tilburg, Cornelis M., primary, Pfaff, Elke, primary, Pajtler, Kristian W., primary, Langenberg, Karin P.S., primary, Fiesel, Petra, primary, Jones, Barbara C., primary, Balasubramanian, Gnana Prakash, primary, Stark, Sebastian, primary, Johann, Pascal D., primary, Blattner-Johnson, Mirjam, primary, Schramm, Kathrin, primary, Dikow, Nicola, primary, Hirsch, Steffen, primary, Sutter, Christian, primary, Grund, Kerstin, primary, von Stackelberg, Arend, primary, Kulozik, Andreas E., primary, Lissat, Andrej, primary, Borkhardt, Arndt, primary, Meisel, Roland, primary, Reinhardt, Dirk, primary, Klusmann, Jan-Henning, primary, Fleischhack, Gudrun, primary, Tippelt, Stephan, primary, von Schweinitz, Dietrich, primary, Schmid, Irene, primary, Kramm, Christof M., primary, von Bueren, André O., primary, Calaminus, Gabriele, primary, Vorwerk, Peter, primary, Graf, Norbert, primary, Westermann, Frank, primary, Fischer, Matthias, primary, Eggert, Angelika, primary, Burkhardt, Birgit, primary, Wößmann, Wilhelm, primary, Nathrath, Michaela, primary, Hecker-Nolting, Stefanie, primary, Frühwald, Michael C., primary, Schneider, Dominik T., primary, Brecht, Ines B., primary, Ketteler, Petra, primary, Fulda, Simone, primary, Koscielniak, Ewa, primary, Meister, Michael T., primary, Scheer, Monika, primary, Hettmer, Simone, primary, Schwab, Matthias, primary, Tremmel, Roman, primary, Øra, Ingrid, primary, Hutter, Caroline, primary, Gerber, Nicolas U., primary, Lohi, Olli, primary, Kazanowska, Bernarda, primary, Kattamis, Antonis, primary, Filippidou, Maria, primary, Goemans, Bianca, primary, Zwaan, C. Michel, primary, Milde, Till, primary, Jäger, Natalie, primary, Wolf, Stephan, primary, Reuss, David, primary, Sahm, Felix, primary, von Deimling, Andreas, primary, Dirksen, Uta, primary, Freitag, Angelika, primary, Witt, Ruth, primary, Lichter, Peter, primary, Kopp-Schneider, Annette, primary, Jones, David T.W., primary, Molenaar, Jan J., primary, Capper, David, primary, Pfister, Stefan M., primary, and Witt, Olaf, primary

Published
2023
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43. Supplementary Data from Infant High-Grade Gliomas Comprise Multiple Subgroups Characterized by Novel Targetable Gene Fusions and Favorable Outcomes

Author

Clarke, Matthew, primary, Mackay, Alan, primary, Ismer, Britta, primary, Pickles, Jessica C., primary, Tatevossian, Ruth G., primary, Newman, Scott, primary, Bale, Tejus A., primary, Stoler, Iris, primary, Izquierdo, Elisa, primary, Temelso, Sara, primary, Carvalho, Diana M., primary, Molinari, Valeria, primary, Burford, Anna, primary, Howell, Louise, primary, Virasami, Alex, primary, Fairchild, Amy R., primary, Avery, Aimee, primary, Chalker, Jane, primary, Kristiansen, Mark, primary, Haupfear, Kelly, primary, Dalton, James D., primary, Orisme, Wilda, primary, Wen, Ji, primary, Hubank, Michael, primary, Kurian, Kathreena M., primary, Rowe, Catherine, primary, Maybury, Mellissa, primary, Crosier, Stephen, primary, Knipstein, Jeffrey, primary, Schüller, Ulrich, primary, Kordes, Uwe, primary, Kram, David E., primary, Snuderl, Matija, primary, Bridges, Leslie, primary, Martin, Andrew J., primary, Doey, Lawrence J., primary, Al-Sarraj, Safa, primary, Chandler, Christopher, primary, Zebian, Bassel, primary, Cairns, Claire, primary, Natrajan, Rachael, primary, Boult, Jessica K.R., primary, Robinson, Simon P., primary, Sill, Martin, primary, Dunkel, Ira J., primary, Gilheeney, Stephen W., primary, Rosenblum, Marc K., primary, Hughes, Debbie, primary, Proszek, Paula Z., primary, Macdonald, Tobey J., primary, Preusser, Matthias, primary, Haberler, Christine, primary, Slavc, Irene, primary, Packer, Roger, primary, Ng, Ho-Keung, primary, Caspi, Shani, primary, Popović, Mara, primary, Faganel Kotnik, Barbara, primary, Wood, Matthew D., primary, Baird, Lissa, primary, Davare, Monika Ashok, primary, Solomon, David A., primary, Olsen, Thale Kristin, primary, Brandal, Petter, primary, Farrell, Michael, primary, Cryan, Jane B., primary, Capra, Michael, primary, Karremann, Michael, primary, Schittenhelm, Jens, primary, Schuhmann, Martin U., primary, Ebinger, Martin, primary, Dinjens, Winand N.M., primary, Kerl, Kornelius, primary, Hettmer, Simone, primary, Pietsch, Torsten, primary, Andreiuolo, Felipe, primary, Driever, Pablo Hernáiz, primary, Korshunov, Andrey, primary, Hiddingh, Lotte, primary, Worst, Barbara C., primary, Sturm, Dominik, primary, Zuckermann, Marc, primary, Witt, Olaf, primary, Bloom, Tabitha, primary, Mitchell, Clare, primary, Miele, Evelina, primary, Colafati, Giovanna Stefania, primary, Diomedi-Camassei, Francesca, primary, Bailey, Simon, primary, Moore, Andrew S., primary, Hassall, Timothy E.G., primary, Lowis, Stephen P., primary, Tsoli, Maria, primary, Cowley, Mark J., primary, Ziegler, David S., primary, Karajannis, Matthias A., primary, Aquilina, Kristian, primary, Hargrave, Darren R., primary, Carceller, Fernando, primary, Marshall, Lynley V., primary, von Deimling, Andreas, primary, Kramm, Christof M., primary, Pfister, Stefan M., primary, Sahm, Felix, primary, Baker, Suzanne J., primary, Mastronuzzi, Angela, primary, Carai, Andrea, primary, Vinci, Maria, primary, Capper, David, primary, Popov, Sergey, primary, Ellison, David W., primary, Jacques, Thomas S., primary, Jones, David T.W., primary, and Jones, Chris, primary

Published
2023
Full Text
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44. Supplementary Table S3 from Infant High-Grade Gliomas Comprise Multiple Subgroups Characterized by Novel Targetable Gene Fusions and Favorable Outcomes

Author

Clarke, Matthew, primary, Mackay, Alan, primary, Ismer, Britta, primary, Pickles, Jessica C., primary, Tatevossian, Ruth G., primary, Newman, Scott, primary, Bale, Tejus A., primary, Stoler, Iris, primary, Izquierdo, Elisa, primary, Temelso, Sara, primary, Carvalho, Diana M., primary, Molinari, Valeria, primary, Burford, Anna, primary, Howell, Louise, primary, Virasami, Alex, primary, Fairchild, Amy R., primary, Avery, Aimee, primary, Chalker, Jane, primary, Kristiansen, Mark, primary, Haupfear, Kelly, primary, Dalton, James D., primary, Orisme, Wilda, primary, Wen, Ji, primary, Hubank, Michael, primary, Kurian, Kathreena M., primary, Rowe, Catherine, primary, Maybury, Mellissa, primary, Crosier, Stephen, primary, Knipstein, Jeffrey, primary, Schüller, Ulrich, primary, Kordes, Uwe, primary, Kram, David E., primary, Snuderl, Matija, primary, Bridges, Leslie, primary, Martin, Andrew J., primary, Doey, Lawrence J., primary, Al-Sarraj, Safa, primary, Chandler, Christopher, primary, Zebian, Bassel, primary, Cairns, Claire, primary, Natrajan, Rachael, primary, Boult, Jessica K.R., primary, Robinson, Simon P., primary, Sill, Martin, primary, Dunkel, Ira J., primary, Gilheeney, Stephen W., primary, Rosenblum, Marc K., primary, Hughes, Debbie, primary, Proszek, Paula Z., primary, Macdonald, Tobey J., primary, Preusser, Matthias, primary, Haberler, Christine, primary, Slavc, Irene, primary, Packer, Roger, primary, Ng, Ho-Keung, primary, Caspi, Shani, primary, Popović, Mara, primary, Faganel Kotnik, Barbara, primary, Wood, Matthew D., primary, Baird, Lissa, primary, Davare, Monika Ashok, primary, Solomon, David A., primary, Olsen, Thale Kristin, primary, Brandal, Petter, primary, Farrell, Michael, primary, Cryan, Jane B., primary, Capra, Michael, primary, Karremann, Michael, primary, Schittenhelm, Jens, primary, Schuhmann, Martin U., primary, Ebinger, Martin, primary, Dinjens, Winand N.M., primary, Kerl, Kornelius, primary, Hettmer, Simone, primary, Pietsch, Torsten, primary, Andreiuolo, Felipe, primary, Driever, Pablo Hernáiz, primary, Korshunov, Andrey, primary, Hiddingh, Lotte, primary, Worst, Barbara C., primary, Sturm, Dominik, primary, Zuckermann, Marc, primary, Witt, Olaf, primary, Bloom, Tabitha, primary, Mitchell, Clare, primary, Miele, Evelina, primary, Colafati, Giovanna Stefania, primary, Diomedi-Camassei, Francesca, primary, Bailey, Simon, primary, Moore, Andrew S., primary, Hassall, Timothy E.G., primary, Lowis, Stephen P., primary, Tsoli, Maria, primary, Cowley, Mark J., primary, Ziegler, David S., primary, Karajannis, Matthias A., primary, Aquilina, Kristian, primary, Hargrave, Darren R., primary, Carceller, Fernando, primary, Marshall, Lynley V., primary, von Deimling, Andreas, primary, Kramm, Christof M., primary, Pfister, Stefan M., primary, Sahm, Felix, primary, Baker, Suzanne J., primary, Mastronuzzi, Angela, primary, Carai, Andrea, primary, Vinci, Maria, primary, Capper, David, primary, Popov, Sergey, primary, Ellison, David W., primary, Jacques, Thomas S., primary, Jones, David T.W., primary, and Jones, Chris, primary

Published
2023
Full Text
View/download PDF

45. Data from The Pediatric Precision Oncology INFORM Registry: Clinical Outcome and Benefit for Patients with Very High-Evidence Targets

Author

van Tilburg, Cornelis M., primary, Pfaff, Elke, primary, Pajtler, Kristian W., primary, Langenberg, Karin P.S., primary, Fiesel, Petra, primary, Jones, Barbara C., primary, Balasubramanian, Gnana Prakash, primary, Stark, Sebastian, primary, Johann, Pascal D., primary, Blattner-Johnson, Mirjam, primary, Schramm, Kathrin, primary, Dikow, Nicola, primary, Hirsch, Steffen, primary, Sutter, Christian, primary, Grund, Kerstin, primary, von Stackelberg, Arend, primary, Kulozik, Andreas E., primary, Lissat, Andrej, primary, Borkhardt, Arndt, primary, Meisel, Roland, primary, Reinhardt, Dirk, primary, Klusmann, Jan-Henning, primary, Fleischhack, Gudrun, primary, Tippelt, Stephan, primary, von Schweinitz, Dietrich, primary, Schmid, Irene, primary, Kramm, Christof M., primary, von Bueren, André O., primary, Calaminus, Gabriele, primary, Vorwerk, Peter, primary, Graf, Norbert, primary, Westermann, Frank, primary, Fischer, Matthias, primary, Eggert, Angelika, primary, Burkhardt, Birgit, primary, Wößmann, Wilhelm, primary, Nathrath, Michaela, primary, Hecker-Nolting, Stefanie, primary, Frühwald, Michael C., primary, Schneider, Dominik T., primary, Brecht, Ines B., primary, Ketteler, Petra, primary, Fulda, Simone, primary, Koscielniak, Ewa, primary, Meister, Michael T., primary, Scheer, Monika, primary, Hettmer, Simone, primary, Schwab, Matthias, primary, Tremmel, Roman, primary, Øra, Ingrid, primary, Hutter, Caroline, primary, Gerber, Nicolas U., primary, Lohi, Olli, primary, Kazanowska, Bernarda, primary, Kattamis, Antonis, primary, Filippidou, Maria, primary, Goemans, Bianca, primary, Zwaan, C. Michel, primary, Milde, Till, primary, Jäger, Natalie, primary, Wolf, Stephan, primary, Reuss, David, primary, Sahm, Felix, primary, von Deimling, Andreas, primary, Dirksen, Uta, primary, Freitag, Angelika, primary, Witt, Ruth, primary, Lichter, Peter, primary, Kopp-Schneider, Annette, primary, Jones, David T.W., primary, Molenaar, Jan J., primary, Capper, David, primary, Pfister, Stefan M., primary, and Witt, Olaf, primary

Published
2023
Full Text
View/download PDF

46. Supplementary Figure from The Pediatric Precision Oncology INFORM Registry: Clinical Outcome and Benefit for Patients with Very High-Evidence Targets

Author

van Tilburg, Cornelis M., primary, Pfaff, Elke, primary, Pajtler, Kristian W., primary, Langenberg, Karin P.S., primary, Fiesel, Petra, primary, Jones, Barbara C., primary, Balasubramanian, Gnana Prakash, primary, Stark, Sebastian, primary, Johann, Pascal D., primary, Blattner-Johnson, Mirjam, primary, Schramm, Kathrin, primary, Dikow, Nicola, primary, Hirsch, Steffen, primary, Sutter, Christian, primary, Grund, Kerstin, primary, von Stackelberg, Arend, primary, Kulozik, Andreas E., primary, Lissat, Andrej, primary, Borkhardt, Arndt, primary, Meisel, Roland, primary, Reinhardt, Dirk, primary, Klusmann, Jan-Henning, primary, Fleischhack, Gudrun, primary, Tippelt, Stephan, primary, von Schweinitz, Dietrich, primary, Schmid, Irene, primary, Kramm, Christof M., primary, von Bueren, André O., primary, Calaminus, Gabriele, primary, Vorwerk, Peter, primary, Graf, Norbert, primary, Westermann, Frank, primary, Fischer, Matthias, primary, Eggert, Angelika, primary, Burkhardt, Birgit, primary, Wößmann, Wilhelm, primary, Nathrath, Michaela, primary, Hecker-Nolting, Stefanie, primary, Frühwald, Michael C., primary, Schneider, Dominik T., primary, Brecht, Ines B., primary, Ketteler, Petra, primary, Fulda, Simone, primary, Koscielniak, Ewa, primary, Meister, Michael T., primary, Scheer, Monika, primary, Hettmer, Simone, primary, Schwab, Matthias, primary, Tremmel, Roman, primary, Øra, Ingrid, primary, Hutter, Caroline, primary, Gerber, Nicolas U., primary, Lohi, Olli, primary, Kazanowska, Bernarda, primary, Kattamis, Antonis, primary, Filippidou, Maria, primary, Goemans, Bianca, primary, Zwaan, C. Michel, primary, Milde, Till, primary, Jäger, Natalie, primary, Wolf, Stephan, primary, Reuss, David, primary, Sahm, Felix, primary, von Deimling, Andreas, primary, Dirksen, Uta, primary, Freitag, Angelika, primary, Witt, Ruth, primary, Lichter, Peter, primary, Kopp-Schneider, Annette, primary, Jones, David T.W., primary, Molenaar, Jan J., primary, Capper, David, primary, Pfister, Stefan M., primary, and Witt, Olaf, primary

Published
2023
Full Text
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47. Supplementary Table from FOXR2 Is an Epigenetically Regulated Pan-Cancer Oncogene That Activates ETS Transcriptional Circuits

Author

Tsai, Jessica W., primary, Cejas, Paloma, primary, Wang, Dayle K., primary, Patel, Smruti, primary, Wu, David W., primary, Arounleut, Phonepasong, primary, Wei, Xin, primary, Zhou, Ningxuan, primary, Syamala, Sudeepa, primary, Dubois, Frank P.B., primary, Crane, Alexander, primary, Pelton, Kristine, primary, Vogelzang, Jayne, primary, Sousa, Cecilia, primary, Baguette, Audrey, primary, Chen, Xiaolong, primary, Condurat, Alexandra L., primary, Dixon-Clarke, Sarah E., primary, Zhou, Kevin N., primary, Lu, Sophie D., primary, Gonzalez, Elizabeth M., primary, Chacon, Madison S., primary, Digiacomo, Jeromy J., primary, Kumbhani, Rushil, primary, Novikov, Dana, primary, Hunter, J'Ya, primary, Tsoli, Maria, primary, Ziegler, David S., primary, Dirksen, Uta, primary, Jager, Natalie, primary, Balasubramanian, Gnana Prakash, primary, Kramm, Christof M., primary, Nathrath, Michaela, primary, Bielack, Stefan, primary, Baker, Suzanne J., primary, Zhang, Jinghui, primary, McFarland, James M., primary, Getz, Gad, primary, Aguet, François, primary, Jabado, Nada, primary, Witt, Olaf, primary, Pfister, Stefan M., primary, Ligon, Keith L., primary, Hovestadt, Volker, primary, Kleinman, Claudia L., primary, Long, Henry, primary, Jones, David T.W., primary, Bandopadhayay, Pratiti, primary, and Phoenix, Timothy N., primary

Published
2023
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48. Supplementary Figure from FOXR2 Is an Epigenetically Regulated Pan-Cancer Oncogene That Activates ETS Transcriptional Circuits

Author

Tsai, Jessica W., primary, Cejas, Paloma, primary, Wang, Dayle K., primary, Patel, Smruti, primary, Wu, David W., primary, Arounleut, Phonepasong, primary, Wei, Xin, primary, Zhou, Ningxuan, primary, Syamala, Sudeepa, primary, Dubois, Frank P.B., primary, Crane, Alexander, primary, Pelton, Kristine, primary, Vogelzang, Jayne, primary, Sousa, Cecilia, primary, Baguette, Audrey, primary, Chen, Xiaolong, primary, Condurat, Alexandra L., primary, Dixon-Clarke, Sarah E., primary, Zhou, Kevin N., primary, Lu, Sophie D., primary, Gonzalez, Elizabeth M., primary, Chacon, Madison S., primary, Digiacomo, Jeromy J., primary, Kumbhani, Rushil, primary, Novikov, Dana, primary, Hunter, J'Ya, primary, Tsoli, Maria, primary, Ziegler, David S., primary, Dirksen, Uta, primary, Jager, Natalie, primary, Balasubramanian, Gnana Prakash, primary, Kramm, Christof M., primary, Nathrath, Michaela, primary, Bielack, Stefan, primary, Baker, Suzanne J., primary, Zhang, Jinghui, primary, McFarland, James M., primary, Getz, Gad, primary, Aguet, François, primary, Jabado, Nada, primary, Witt, Olaf, primary, Pfister, Stefan M., primary, Ligon, Keith L., primary, Hovestadt, Volker, primary, Kleinman, Claudia L., primary, Long, Henry, primary, Jones, David T.W., primary, Bandopadhayay, Pratiti, primary, and Phoenix, Timothy N., primary

Published
2023
Full Text
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49. Data from FOXR2 Is an Epigenetically Regulated Pan-Cancer Oncogene That Activates ETS Transcriptional Circuits

Author

Tsai, Jessica W., primary, Cejas, Paloma, primary, Wang, Dayle K., primary, Patel, Smruti, primary, Wu, David W., primary, Arounleut, Phonepasong, primary, Wei, Xin, primary, Zhou, Ningxuan, primary, Syamala, Sudeepa, primary, Dubois, Frank P.B., primary, Crane, Alexander, primary, Pelton, Kristine, primary, Vogelzang, Jayne, primary, Sousa, Cecilia, primary, Baguette, Audrey, primary, Chen, Xiaolong, primary, Condurat, Alexandra L., primary, Dixon-Clarke, Sarah E., primary, Zhou, Kevin N., primary, Lu, Sophie D., primary, Gonzalez, Elizabeth M., primary, Chacon, Madison S., primary, Digiacomo, Jeromy J., primary, Kumbhani, Rushil, primary, Novikov, Dana, primary, Hunter, J'Ya, primary, Tsoli, Maria, primary, Ziegler, David S., primary, Dirksen, Uta, primary, Jager, Natalie, primary, Balasubramanian, Gnana Prakash, primary, Kramm, Christof M., primary, Nathrath, Michaela, primary, Bielack, Stefan, primary, Baker, Suzanne J., primary, Zhang, Jinghui, primary, McFarland, James M., primary, Getz, Gad, primary, Aguet, François, primary, Jabado, Nada, primary, Witt, Olaf, primary, Pfister, Stefan M., primary, Ligon, Keith L., primary, Hovestadt, Volker, primary, Kleinman, Claudia L., primary, Long, Henry, primary, Jones, David T.W., primary, Bandopadhayay, Pratiti, primary, and Phoenix, Timothy N., primary

Published
2023
Full Text
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50. Antimicrobial use in pediatric oncology and hematology in Germany and Austria, 2020/2021: a cross-sectional, multi-center point-prevalence study with a multi-step qualitative adjudication process

Author

Papan, Cihan, primary, Reifenrath, Katharina, additional, Last, Katharina, additional, Attarbaschi, Andishe, additional, Graf, Norbert, additional, Groll, Andreas H., additional, Hübner, Johannes, additional, Laws, Hans-Jürgen, additional, Lehrnbecher, Thomas, additional, Liese, Johannes G., additional, Martin, Luise, additional, Tenenbaum, Tobias, additional, Vieth, Simon, additional, von Both, Ulrich, additional, Wagenpfeil, Gudrun, additional, Weichert, Stefan, additional, Hufnagel, Markus, additional, Simon, Arne, additional, Baier, Jan, additional, Balzer, Stefan, additional, Behr, Ümmügül, additional, Bernbeck, Benedikt, additional, Beutel, Karin, additional, Blattmann, Claudia, additional, Bochennek, Konrad, additional, Cario, Holger, additional, Eggert, Angelika, additional, Ehlert, Karoline, additional, Göpner, Simone, additional, Kontny, Udo, additional, Körholz, Dieter, additional, Kramm, Christof, additional, Lauten, Melchior, additional, Lessel, Lienhard, additional, Linderkamp, Christin, additional, Lobitz, Stephan, additional, Maas, Volker, additional, Misgeld, Rainer, additional, Mücke, Urs, additional, Neubert, Jennifer, additional, Nonnenmacher, Lisa, additional, Queudeville, Manon, additional, Redlich, Antje, additional, Rodehüser, Martina, additional, Schober, Sarah, additional, Siepermann, Meinolf, additional, Simon, Thorsten, additional, Souliman, Hadi, additional, Stiefel, Martina, additional, Wiegering, Verena, additional, and Winkler, Beate, additional

Published
2023
Full Text
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