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516 results on '"Krane, Jeffrey F."'

2. Dynamic optical contrast imaging for real-time delineation of tumor resection margins using head and neck cancer as a model

Author

Hu, Yong, Huang, Shan, Han, Albert Y., Moon, Seong, Krane, Jeffrey F., Stafsudd, Oscar, Grundfest, Warren, and John, Maie A. St.

Subjects
Electrical Engineering and Systems Science - Image and Video Processing, Electrical Engineering and Systems Science - Systems and Control, Physics - Biological Physics, Physics - Medical Physics
Abstract

Complete surgical resection of the tumor for Head and neck squamous cell carcinoma (HNSCC) remains challenging, given the devastating side effects of aggressive surgery and the anatomic proximity to vital structures. To address the clinical challenges, we introduce a wide-field, label-free imaging tool that can assist surgeons delineate tumor margins real-time. We assume that autofluorescence lifetime is a natural indicator of the health level of tissues, and ratio-metric measurement of the emission-decay state to the emission-peak state of excited fluorophores will enable rapid lifetime mapping of tissues. Here, we describe the principle, instrumentation, characterization of the imager and the intraoperative imaging of resected tissues from 13 patients undergoing head and neck cancer resection. 20 x 20 mm2 imaging takes 2 second/frame with a working distance of 50 mm, and characterization shows that the spatial resolution reached 70 {\mu}m and the least distinguishable fluorescence lifetime difference is 0.14 ns. Tissue imaging and Hematoxylin-Eosin stain slides comparison reveals its capability of delineating cancerous boundaries with submillimeter accuracy and a sensitivity of 91.86% and specificity of 84.38%., Comment: 21 pages, 7 figures and 1 table

Published
2022

3. Modular polymer platform as a novel approach to head and neck cancer therapy

Author

Alhiyari, Yazeed, Shao, Jundong, Han, Albert Y, Miller, Amanda, Krane, Jeffrey F, Luff, Marie, Momcilovic, Milica, Shackelford, David, Gu, Zhen, and John, Maie A St

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Rare Diseases, Biotechnology, Dental/Oral and Craniofacial Disease, Cancer, Bioengineering, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, Animals, Chemoradiotherapy, Adjuvant, Head and Neck Neoplasms, Humans, Mice, Polymers, Quality of Life
Abstract

Head and neck cancer is the sixth most common cancer in the world, with more than 300,000 deaths attributed to the disease annually. Aggressive surgical resection often with adjuvant chemoradiation is the cornerstone of treatment. However, the necessary chemoradiation treatment can result in collateral damage to adjacent vital structures causing a profound impact on quality of life. Here, we present a novel polymer of poly(lactic-co-glycolic) acid and polyvinyl alcohol that can serve as a versatile multidrug delivery platform as well as for detection on cross-sectional imaging while functioning as a fiduciary marker for postoperative radiotherapy and radiotherapeutic dosing. In a mouse xenograft model, the dual-layered polymer composed of calcium carbonate/thymoquinone was used for both polymer localization and narrow-field infusion of a natural therapeutic compound. A similar approach can be applied in the treatment of head and neck cancer patients, where immunotherapy and traditional chemotherapy can be delivered simultaneously with independent release kinetics.

Published
2022

4. Malignant

Author

Mehrotra, Swati, Al-Abbadi, Mousa, Bigorgne, Claude, Jalalay, Jalal, Krane, Jeffrey F., Perak, Renata B., Vielh, Philippe, Wakely, Paul E., Jr, Wang, He, Wojcik, Eva M., Barkan, Güliz A., Faquin, William C., editor, Rossi, Esther Diana, editor, Baloch, Zubair, editor, Barkan, Güliz A., editor, Foschini, Maria Pia, editor, Kurtycz, Daniel F.I., editor, Pusztaszeri, Marc P., editor, and Vielh, Philippe, editor

Published
2023
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5. Ancillary Studies for Salivary Gland Cytology

Author

Pusztaszeri, Marc P., Jo, Vickie Y., Krane, Jeffrey F., Jiang, Xiaoyin “Sara”, Vielh, Philippe, Faquin, William C., editor, Rossi, Esther Diana, editor, Baloch, Zubair, editor, Barkan, Güliz A., editor, Foschini, Maria Pia, editor, Kurtycz, Daniel F.I., editor, Pusztaszeri, Marc P., editor, and Vielh, Philippe, editor

Published
2023
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6. Neoplasm

Author

Baloch, Zubair, Fadda, Guido, Griffith, Christopher C., Klijanienko, Jerzy, Krane, Jeffrey F., Layfield, Lester, Maleki, Zahra, Nayar, Ritu, Pusztaszeri, Marc P., Faquin, William C., editor, Rossi, Esther Diana, editor, Baloch, Zubair, editor, Barkan, Güliz A., editor, Foschini, Maria Pia, editor, Kurtycz, Daniel F.I., editor, Pusztaszeri, Marc P., editor, and Vielh, Philippe, editor

Published
2023
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12. Neoplasm

Author

Baloch, Zubair, Fadda, Guido, Fırat, Pınar, Klijanienko, Jerzey, Krane, Jeffrey F., Layfield, Lester, Nayar, Ritu, Powers, Celeste N., Pusztaszeri, Marc, Faquin, William C., editor, Rossi, Esther Diana, editor, Baloch, Zubair, editor, Barkan, Güliz A., editor, Foschini, Maria P., editor, Kurtycz, Daniel F.I., editor, Pusztaszeri, Marc, editor, and Vielh, Philippe, editor

Published
2018
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16. Evaluating the PD-1 Axis and Immune Effector Cell Infiltration in Oropharyngeal Squamous Cell Carcinoma

Author

Schoenfeld, Jonathan D., Gjini, Evisa, Rodig, Scott J., Tishler, Roy B., Rawal, Bhupendra, Catalano, Paul J., Uppaluri, Ravindra, Haddad, Robert I., Hanna, Glenn J., Chau, Nicole G., Rabinowits, Guilherme, Lorch, Jochen, Jo, Vickie Y., Krane, Jeffrey F., Goguen, Laura A., Annino, Donald J., Abdelrahman, Sara, Lipschitz, Mikel, and Margalit, Danielle N.

Published
2018
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25. Molecular Testing of Nodules with a Suspicious or Malignant Cytologic Diagnosis in the Setting of Non-Invasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features (NIFTP)

Author

Strickland, Kyle C., Eszlinger, Markus, Paschke, Ralf, Angell, Trevor E., Alexander, Erik K., Marqusee, Ellen, Nehs, Matthew A., Jo, Vickie Y., Lowe, Alarice, Vivero, Marina, Hollowell, Monica, Qian, Xiaohua, Wieczorek, Tad, French, Christopher A., Teot, Lisa A., Cibas, Edmund S., Lindeman, Neal I., Krane, Jeffrey F., and Barletta, Justine A.

Published
2018
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26. Supplementary Figure 1 from Incorporation of Next-Generation Sequencing into Routine Clinical Care to Direct Treatment of Head and Neck Squamous Cell Carcinoma

Author

Chau, Nicole G., primary, Li, Yvonne Y., primary, Jo, Vickie Y., primary, Rabinowits, Guilherme, primary, Lorch, Jochen H., primary, Tishler, Roy B., primary, Margalit, Danielle N., primary, Schoenfeld, Jonathan D., primary, Annino, Don J., primary, Goguen, Laura A., primary, Thomas, Tom, primary, Becker, Hailey, primary, Haddad, Tyler, primary, Krane, Jeffrey F., primary, Lindeman, Neal I., primary, Shapiro, Geoffrey I., primary, Haddad, Robert I., primary, and Hammerman, Peter S., primary

Published
2023
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27. Data from Incorporation of Next-Generation Sequencing into Routine Clinical Care to Direct Treatment of Head and Neck Squamous Cell Carcinoma

Author

Chau, Nicole G., primary, Li, Yvonne Y., primary, Jo, Vickie Y., primary, Rabinowits, Guilherme, primary, Lorch, Jochen H., primary, Tishler, Roy B., primary, Margalit, Danielle N., primary, Schoenfeld, Jonathan D., primary, Annino, Don J., primary, Goguen, Laura A., primary, Thomas, Tom, primary, Becker, Hailey, primary, Haddad, Tyler, primary, Krane, Jeffrey F., primary, Lindeman, Neal I., primary, Shapiro, Geoffrey I., primary, Haddad, Robert I., primary, and Hammerman, Peter S., primary

Published
2023
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28. Supplementary Figure 5 from Incorporation of Next-Generation Sequencing into Routine Clinical Care to Direct Treatment of Head and Neck Squamous Cell Carcinoma

Author

Chau, Nicole G., primary, Li, Yvonne Y., primary, Jo, Vickie Y., primary, Rabinowits, Guilherme, primary, Lorch, Jochen H., primary, Tishler, Roy B., primary, Margalit, Danielle N., primary, Schoenfeld, Jonathan D., primary, Annino, Don J., primary, Goguen, Laura A., primary, Thomas, Tom, primary, Becker, Hailey, primary, Haddad, Tyler, primary, Krane, Jeffrey F., primary, Lindeman, Neal I., primary, Shapiro, Geoffrey I., primary, Haddad, Robert I., primary, and Hammerman, Peter S., primary

Published
2023
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29. Supplementary Figure 2 from Incorporation of Next-Generation Sequencing into Routine Clinical Care to Direct Treatment of Head and Neck Squamous Cell Carcinoma

Author

Chau, Nicole G., primary, Li, Yvonne Y., primary, Jo, Vickie Y., primary, Rabinowits, Guilherme, primary, Lorch, Jochen H., primary, Tishler, Roy B., primary, Margalit, Danielle N., primary, Schoenfeld, Jonathan D., primary, Annino, Don J., primary, Goguen, Laura A., primary, Thomas, Tom, primary, Becker, Hailey, primary, Haddad, Tyler, primary, Krane, Jeffrey F., primary, Lindeman, Neal I., primary, Shapiro, Geoffrey I., primary, Haddad, Robert I., primary, and Hammerman, Peter S., primary

Published
2023
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30. Supplementary Figure 3 from Incorporation of Next-Generation Sequencing into Routine Clinical Care to Direct Treatment of Head and Neck Squamous Cell Carcinoma

Author

Chau, Nicole G., primary, Li, Yvonne Y., primary, Jo, Vickie Y., primary, Rabinowits, Guilherme, primary, Lorch, Jochen H., primary, Tishler, Roy B., primary, Margalit, Danielle N., primary, Schoenfeld, Jonathan D., primary, Annino, Don J., primary, Goguen, Laura A., primary, Thomas, Tom, primary, Becker, Hailey, primary, Haddad, Tyler, primary, Krane, Jeffrey F., primary, Lindeman, Neal I., primary, Shapiro, Geoffrey I., primary, Haddad, Robert I., primary, and Hammerman, Peter S., primary

Published
2023
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31. Supplementary Figure 4 from Incorporation of Next-Generation Sequencing into Routine Clinical Care to Direct Treatment of Head and Neck Squamous Cell Carcinoma

Author

Chau, Nicole G., primary, Li, Yvonne Y., primary, Jo, Vickie Y., primary, Rabinowits, Guilherme, primary, Lorch, Jochen H., primary, Tishler, Roy B., primary, Margalit, Danielle N., primary, Schoenfeld, Jonathan D., primary, Annino, Don J., primary, Goguen, Laura A., primary, Thomas, Tom, primary, Becker, Hailey, primary, Haddad, Tyler, primary, Krane, Jeffrey F., primary, Lindeman, Neal I., primary, Shapiro, Geoffrey I., primary, Haddad, Robert I., primary, and Hammerman, Peter S., primary

Published
2023
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32. Supplementary Figure 6 and 7 from Incorporation of Next-Generation Sequencing into Routine Clinical Care to Direct Treatment of Head and Neck Squamous Cell Carcinoma

Author

Chau, Nicole G., primary, Li, Yvonne Y., primary, Jo, Vickie Y., primary, Rabinowits, Guilherme, primary, Lorch, Jochen H., primary, Tishler, Roy B., primary, Margalit, Danielle N., primary, Schoenfeld, Jonathan D., primary, Annino, Don J., primary, Goguen, Laura A., primary, Thomas, Tom, primary, Becker, Hailey, primary, Haddad, Tyler, primary, Krane, Jeffrey F., primary, Lindeman, Neal I., primary, Shapiro, Geoffrey I., primary, Haddad, Robert I., primary, and Hammerman, Peter S., primary

Published
2023
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33. Supplementary Table 3 from Biomarkers of HPV in Head and Neck Squamous Cell Carcinoma

Author

Liang, Caihua, primary, Marsit, Carmen J., primary, McClean, Michael D., primary, Nelson, Heather H., primary, Christensen, Brock C., primary, Haddad, Robert I., primary, Clark, John R., primary, Wein, Richard O., primary, Grillone, Gregory A., primary, Houseman, E. Andres, primary, Halec, Gordana, primary, Waterboer, Tim, primary, Pawlita, Michael, primary, Krane, Jeffrey F., primary, and Kelsey, Karl T., primary

Published
2023
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34. Data from Biomarkers of HPV in Head and Neck Squamous Cell Carcinoma

Author

Liang, Caihua, primary, Marsit, Carmen J., primary, McClean, Michael D., primary, Nelson, Heather H., primary, Christensen, Brock C., primary, Haddad, Robert I., primary, Clark, John R., primary, Wein, Richard O., primary, Grillone, Gregory A., primary, Houseman, E. Andres, primary, Halec, Gordana, primary, Waterboer, Tim, primary, Pawlita, Michael, primary, Krane, Jeffrey F., primary, and Kelsey, Karl T., primary

Published
2023
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35. Supplementary Table 4 from Biomarkers of HPV in Head and Neck Squamous Cell Carcinoma

Author

Liang, Caihua, primary, Marsit, Carmen J., primary, McClean, Michael D., primary, Nelson, Heather H., primary, Christensen, Brock C., primary, Haddad, Robert I., primary, Clark, John R., primary, Wein, Richard O., primary, Grillone, Gregory A., primary, Houseman, E. Andres, primary, Halec, Gordana, primary, Waterboer, Tim, primary, Pawlita, Michael, primary, Krane, Jeffrey F., primary, and Kelsey, Karl T., primary

Published
2023
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36. Supplementary Table 6 from Biomarkers of HPV in Head and Neck Squamous Cell Carcinoma

Author

Liang, Caihua, primary, Marsit, Carmen J., primary, McClean, Michael D., primary, Nelson, Heather H., primary, Christensen, Brock C., primary, Haddad, Robert I., primary, Clark, John R., primary, Wein, Richard O., primary, Grillone, Gregory A., primary, Houseman, E. Andres, primary, Halec, Gordana, primary, Waterboer, Tim, primary, Pawlita, Michael, primary, Krane, Jeffrey F., primary, and Kelsey, Karl T., primary

Published
2023
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37. Supplementary Table 1 from Biomarkers of HPV in Head and Neck Squamous Cell Carcinoma

Author

Liang, Caihua, primary, Marsit, Carmen J., primary, McClean, Michael D., primary, Nelson, Heather H., primary, Christensen, Brock C., primary, Haddad, Robert I., primary, Clark, John R., primary, Wein, Richard O., primary, Grillone, Gregory A., primary, Houseman, E. Andres, primary, Halec, Gordana, primary, Waterboer, Tim, primary, Pawlita, Michael, primary, Krane, Jeffrey F., primary, and Kelsey, Karl T., primary

Published
2023
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38. Supplementary Table 5 from Biomarkers of HPV in Head and Neck Squamous Cell Carcinoma

Author

Liang, Caihua, primary, Marsit, Carmen J., primary, McClean, Michael D., primary, Nelson, Heather H., primary, Christensen, Brock C., primary, Haddad, Robert I., primary, Clark, John R., primary, Wein, Richard O., primary, Grillone, Gregory A., primary, Houseman, E. Andres, primary, Halec, Gordana, primary, Waterboer, Tim, primary, Pawlita, Michael, primary, Krane, Jeffrey F., primary, and Kelsey, Karl T., primary

Published
2023
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39. Supplementary Table 2 from Biomarkers of HPV in Head and Neck Squamous Cell Carcinoma

Author

Liang, Caihua, primary, Marsit, Carmen J., primary, McClean, Michael D., primary, Nelson, Heather H., primary, Christensen, Brock C., primary, Haddad, Robert I., primary, Clark, John R., primary, Wein, Richard O., primary, Grillone, Gregory A., primary, Houseman, E. Andres, primary, Halec, Gordana, primary, Waterboer, Tim, primary, Pawlita, Michael, primary, Krane, Jeffrey F., primary, and Kelsey, Karl T., primary

Published
2023
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40. Supplementary Figure 1 from Biomarkers of HPV in Head and Neck Squamous Cell Carcinoma

Author

Liang, Caihua, primary, Marsit, Carmen J., primary, McClean, Michael D., primary, Nelson, Heather H., primary, Christensen, Brock C., primary, Haddad, Robert I., primary, Clark, John R., primary, Wein, Richard O., primary, Grillone, Gregory A., primary, Houseman, E. Andres, primary, Halec, Gordana, primary, Waterboer, Tim, primary, Pawlita, Michael, primary, Krane, Jeffrey F., primary, and Kelsey, Karl T., primary

Published
2023
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42. Acknowledgments

Author

Chen, Eleanor Y., primary, Cibas, Edmund S., additional, Drapkin, Ronny I., additional, Krane, Jeffrey F., additional, Lazar, Alexander J.F., additional, Nascimento, Alessandra F., additional, Rose, Peter G., additional, Stewart, Elizabeth A., additional, Chang, Priscilla S., additional, Genest, David R., additional, McKee, Phillip H., additional, and Oh, Kristine Y-T, additional

Published
2018
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43. Contributing Authors

Author

Cassarino, David, primary, Chirieac, Lucian R., additional, Cornell, Lynn D., additional, Cox, Roni Michelle, additional, Dillon, Deborah A., additional, Folkerth, Rebecca D., additional, Frishberg, David P., additional, Harrison, Beth T., additional, Jo, Vickie Y., additional, Ko, Christine J., additional, Krane, Jeffrey F., additional, Krasnozhen-Ratush, Olga, additional, Lindberg, Matthew R., additional, Mason, Emily F., additional, Nosé, Vania, additional, Quick, Charles Matthew, additional, Snuderl, Matija, additional, Srivastava, Amitabh, additional, Thompson, Karen S., additional, Kraft, Stefan, additional, and Pfannl, Rolf, additional

Published
2018
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