1. Pulling out the 1%:whole-genome capture for the targeted enrichment of ancient DNA sequencing libraries
- Author
-
Nikola Theodossiev, Cristina Valdiosera, Simon Gravel, Diana Dimitrova, Yingrui Li, Krasimir Leshtakov, M. Thomas P. Gilbert, William J. Greenleaf, Martin Sikora, Andrés Moreno-Estrada, Meredith L. Carpenter, Morten E. Allentoft, Sonia Guillén, Hannes Schroeder, Eske Willerslev, Georgi Nekhrizov, Karla Sandoval, Jason D. Buenrostro, Morten Rasmussen, Jun Wang, Davide Pettener, Carlos Bustamante, Donata Luiselli, Carpenter ML, Buenrostro JD, Valdiosera C, Schroeder H, Allentoft ME, Sikora M, Rasmussen M, Gravel S, Guillén S, Nekhrizov G, Leshtakov K, Dimitrova D, Theodossiev N, Pettener D, Luiselli D, Sandoval K, Moreno-Estrada A, Li Y, Wang J, Gilbert MT, Willerslev E, Greenleaf WJ, and Bustamante CD.
- Subjects
Male ,0106 biological sciences ,Adolescent ,Genomics ,Computational biology ,Biology ,010603 evolutionary biology ,01 natural sciences ,Genome ,Bone and Bones ,Article ,Deep sequencing ,03 medical and health sciences ,Principal Component Analysi ,Neanderthal genome ,MTDNA ,Genetics ,Humans ,ANCIENT DNA ,Genetics(clinical) ,Genomic library ,Environmental DNA ,Child ,History, Ancient ,Genetics (clinical) ,Gene Library ,030304 developmental biology ,Principal Component Analysis ,0303 health sciences ,Fossils ,Shotgun sequencing ,whole genome sequence ,High-Throughput Nucleotide Sequencing ,Nucleic Acid Hybridization ,DNA ,Mummies ,Sequence Analysis, DNA ,aDNA sequencing librarie ,Ancient DNA ,RNA ,Human genome ,Tooth ,Hair - Abstract
Most ancient specimens contain very low levels of endogenous DNA, precluding the shotgun sequencing of many interesting samples because of cost. Ancient DNA (aDNA) libraries often contain
- Published
- 2013
- Full Text
- View/download PDF