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7. Loss of epigenetic information as a cause of mammalian aging

Author

Yang, Jae-Hyun, Hayano, Motoshi, Griffin, Patrick T., Amorim, João A., Bonkowski, Michael S., Apostolides, John K., Salfati, Elias L., Blanchette, Marco, Munding, Elizabeth M., Bhakta, Mital, Chew, Yap Ching, Guo, Wei, Yang, Xiaojing, Maybury-Lewis, Sun, Tian, Xiao, Ross, Jaime M., Coppotelli, Giuseppe, Meer, Margarita V., Rogers-Hammond, Ryan, Vera, Daniel L., Lu, Yuancheng Ryan, Pippin, Jeffrey W., Creswell, Michael L., Dou, Zhixun, Xu, Caiyue, Mitchell, Sarah J., Das, Abhirup, O’Connell, Brendan L., Thakur, Sachin, Kane, Alice E., Su, Qiao, Mohri, Yasuaki, Nishimura, Emi K., Schaevitz, Laura, Garg, Neha, Balta, Ana-Maria, Rego, Meghan A., Gregory-Ksander, Meredith, Jakobs, Tatjana C., Zhong, Lei, Wakimoto, Hiroko, El Andari, Jihad, Grimm, Dirk, Mostoslavsky, Raul, Wagers, Amy J., Tsubota, Kazuo, Bonasera, Stephen J., Palmeira, Carlos M., Seidman, Jonathan G., Seidman, Christine E., Wolf, Norman S., Kreiling, Jill A., Sedivy, John M., Murphy, George F., Green, Richard E., Garcia, Benjamin A., Berger, Shelley L., Oberdoerffer, Philipp, Shankland, Stuart J., Gladyshev, Vadim N., Ksander, Bruce R., Pfenning, Andreas R., Rajman, Luis A., and Sinclair, David A.

Published
2023
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12. Loss of epigenetic information as a cause of mammalian aging

Author

Yang, Jae-Hyun, primary, Hayano, Motoshi, additional, Griffin, Patrick T., additional, Amorim, João A., additional, Bonkowski, Michael S., additional, Apostolides, John K., additional, Salfati, Elias L., additional, Blanchette, Marco, additional, Munding, Elizabeth M., additional, Bhakta, Mital, additional, Chew, Yap Ching, additional, Guo, Wei, additional, Yang, Xiaojing, additional, Maybury-Lewis, Sun, additional, Tian, Xiao, additional, Ross, Jaime M., additional, Coppotelli, Giuseppe, additional, Meer, Margarita V., additional, Rogers-Hammond, Ryan, additional, Vera, Daniel L., additional, Lu, Yuancheng Ryan, additional, Pippin, Jeffrey W., additional, Creswell, Michael L., additional, Dou, Zhixun, additional, Xu, Caiyue, additional, Mitchell, Sarah J., additional, Das, Abhirup, additional, O’Connell, Brendan L., additional, Thakur, Sachin, additional, Kane, Alice E., additional, Su, Qiao, additional, Mohri, Yasuaki, additional, Nishimura, Emi K., additional, Schaevitz, Laura, additional, Garg, Neha, additional, Balta, Ana-Maria, additional, Rego, Meghan A., additional, Gregory-Ksander, Meredith, additional, Jakobs, Tatjana C., additional, Zhong, Lei, additional, Wakimoto, Hiroko, additional, El Andari, Jihad, additional, Grimm, Dirk, additional, Mostoslavsky, Raul, additional, Wagers, Amy J., additional, Tsubota, Kazuo, additional, Bonasera, Stephen J., additional, Palmeira, Carlos M., additional, Seidman, Jonathan G., additional, Seidman, Christine E., additional, Wolf, Norman S., additional, Kreiling, Jill A., additional, Sedivy, John M., additional, Murphy, George F., additional, Green, Richard E., additional, Garcia, Benjamin A., additional, Berger, Shelley L., additional, Oberdoerffer, Philipp, additional, Shankland, Stuart J., additional, Gladyshev, Vadim N., additional, Ksander, Bruce R., additional, Pfenning, Andreas R., additional, Rajman, Luis A., additional, and Sinclair, David A., additional

Published
2024
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23. Sex‐specific aging in animals: Perspective and future directions

Author

Bronikowski, Anne M., primary, Meisel, Richard P., additional, Biga, Peggy R., additional, Walters, James R., additional, Mank, Judith E., additional, Larschan, Erica, additional, Wilkinson, Gerald S., additional, Valenzuela, Nicole, additional, Conard, Ashley Mae, additional, Magalhães, João Pedro, additional, Duan, Jingyue (Ellie), additional, Elias, Amy E., additional, Gamble, Tony, additional, Graze, Rita M., additional, Gribble, Kristin E., additional, Kreiling, Jill A., additional, and Riddle, Nicole C., additional

Published
2022
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26. Loss of Epigenetic Information as a Cause of Mammalian Aging

Author

Yang, Jae-Hyun, primary, Hayano, Motoshi, additional, Griffin, Patrick, additional, Amorim, Joao A., additional, Bonkowski, Michael S., additional, Apostolides, John K., additional, Blanchette, Marco, additional, Munding, Elizabeth M., additional, Bhakta, Mital, additional, Salfati, Elias L., additional, Lu, Yuancheng, additional, Vera, Daniel L., additional, Ross, Jaime M., additional, Coppotelli, Giuseppe, additional, Chew, Yap Ching, additional, Guo, Wei, additional, Yang, Xiaojing, additional, Meer, Margarita V., additional, Tian, Xiao, additional, Dou, Zhixun, additional, Xu, Caiyue, additional, Pippin, Jeffrey W., additional, Creswell, Michael, additional, Mitchell, Sarah J., additional, Das, Abhirup, additional, O’Connell, Brendan L., additional, Thakur, Sachin, additional, Kane, Alice E., additional, Su, Qiao, additional, Mohri, Yasuaki, additional, Nishimura, Emi K., additional, Schaevitz, Laura, additional, Garg, Neha, additional, Balta, Ana-Maria, additional, Rego, Meghan A., additional, Gregory-Ksander, Meredith, additional, Jakobs, Tatjana C., additional, Zhong, Lei, additional, Wakimoto, Hiroko, additional, Mostoslavsky, Raul, additional, Wagers, Amy J., additional, Tsubota, Kazuo, additional, Bonasera, Stephen J., additional, Palmeira, Carlos M., additional, Seidman, Jonathan G., additional, Seidman, Christine, additional, Wolf, Norman S., additional, Kreiling, Jill A., additional, Sedivy, John M., additional, Murphy, George F., additional, Green, Richard E., additional, Garcia, Benjamin A., additional, Berger, Shelley L., additional, Oberdoerffer, Philipp, additional, Shankland, Stuart J., additional, Gladyshev, Vadim N., additional, Ksander, Bruce R., additional, Pfenning, Andreas R., additional, Rajman, Luis A., additional, and Sinclair, David A., additional

Published
2021
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31. Presence and Roles of Calcium Gradients along the Dorsal-Ventral Axis in Drosophila Embryos

Author

Creton, Robbert, Kreiling, Jill A., and Jaffe, Lionel F.

Subjects
Developmental biology -- Research, Embryology -- Research, Cellular signal transduction -- Research, Biological sciences
Abstract

Dorsal-ventral specification of the Drosophila embryo is mediated by signaling pathways which have been very well described in genetic terms. However, little is known about the physiology of Drosophila development. By imaging patterns of free cytosolic calcium in Drosophila embryos, we found that several calcium gradients are generated along the dorsal-ventral axis. The most pronounced gradient is formed during stage 5, in which calcium levels are high dorsally. Manipulation of the stage 5 calcium gradient affects specification of the amnioserosa, the dorsal-most region of the embryo. We further show that this calcium gradient is inhibited in pipe, Toll, and dorsal mutants, but is unaltered in decapentaplegic (dpp) or punt mutants, suggesting that the stage 5 calcium gradient is formed by a suppression of ventral calcium concentrations. We conclude that calcium plays a role in specification of the dorsal embryonic region.

Published
2000

33. Borrelia burgdorferi swims with a planar waveform similar to that of eukaryotic flagella

Author

Goldstein, Stuart F., Charon, Nyles W., and Kreiling, Jill A.

Subjects
Borrelia burgdorferi -- Genetic aspects, Waveforms -- Analysis, Science and technology
Abstract

Borrelia burgdorferi cells swim with planar waveform, identical to that of eukaryotic flagella. B. burgdorferi is a mobile spirochete consisting of several periplasmic flagella (PF), overlaying the cell core. The planar waves are anticlockwise, as observed from posterior end of cell axis. Interaction of PF with cells govern the shape of B. burgdorferi and rotation of PFs from opposite ends cause cell bending.

Published
1994

34. Morphology and dynamics of protruding Spirochete periplasmic flagella

Author

Charon, Nyles W., Goldstein, Stuart F., Block, Steven M., Curci, Kristina, Ruby, John D., Kreiling, Jill A., and Limberger, Ronald J.

Subjects
Spirochetes -- Research, Bacteria -- Motility, Flagella (Microbiology) -- Research, Treponema -- Research, Biological sciences
Abstract

Protrusions observed on Treponema phagedenis were characterized through microscopic and micromanipulation techniques. The protrusions were shown to be bundles of periplasmic flagella (PF) surrounded by a membrane sheath. The protrusions could gyrate, propagating clockwise or counterclockwise helical waves, stop and reverse direction. Observations on flagellar motion indicated that the PFs associated with the protrusions rotate in a manner similar to flagella in rod-shaped bacteria. The results confirm previous models on the Spirochete motility through periplasmic flagella, as well as describing an alternate mode of motility using protrusions.

Published
1992

35. DNA Break-Induced Epigenetic Drift as a Cause of Mammalian Aging

Author

Hayano, Motoshi, primary, Yang, Jae-Hyun, additional, Bonkowski, Michael S., additional, Amorim, Joao A., additional, Ross, Jaime M., additional, Coppotelli, Giuseppe, additional, Griffin, Patrick T., additional, Chew, Yap Ching, additional, Guo, Wei, additional, Yang, Xiaojing, additional, Vera, Daniel L., additional, Salfati, Elias L., additional, Das, Abhirup, additional, Thakur, Sachin, additional, Kane, Alice E., additional, Mitchell, Sarah J., additional, Mohri, Yasuaki, additional, Nishimura, Emi K., additional, Schaevitz, Laura, additional, Garg, Neha, additional, Balta, Ana-Maria, additional, Rego, Meghan A., additional, Gregory-Ksander, Meredith, additional, Jakobs, Tatjana C., additional, Zhong, Lei, additional, Wakimoto, Hiroko, additional, Mostoslavsky, Raul, additional, Wagers, Amy J., additional, Tsubota, Kazuo, additional, Bonasera, Stephen J., additional, Palmeira, Carlos M., additional, Seidman, Jonathan G., additional, Seidman, Christine E., additional, Wolf, Norman S., additional, Kreiling, Jill A., additional, Sedivy, John M., additional, Murphy, George F., additional, Oberdoerffer, Philipp, additional, Ksander, Bruce R., additional, Rajman, Luis A., additional, and Sinclair, David A., additional

Published
2019
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41. Age-associated increase in heterochromatic marks in murine and primate tissues

Author

Kreiling, Jill A., Tamamori-Adachi, Mimi, Sexton, Alec N., Jeyapalan, Jessie C., Munoz-Najar, Ursula, Peterson, Abigail L., Manivannan, Jayameenakshi, Rogers, Elizabeth S., Pchelintsev, Nikolay A., Adams, Peter D., and Sedivy, John M.

Subjects
Primates, Aging, Fluorescent Antibody Technique, Fibroblasts, Article, Epigenesis, Genetic, Mice, Liver, Chromobox Protein Homolog 5, Heterochromatin, Animals, Humans, Muscle, Skeletal, Lung
Abstract

Chromatin is highly dynamic and subject to extensive remodeling under many physiologic conditions. Changes in chromatin that occur during the aging process are poorly documented and understood in higher organisms, such as mammals. We developed an immunofluorescence assay to quantitatively detect, at the single cell level, changes in the nuclear content of chromatin-associated proteins. We found increased levels of the heterochromatin-associated proteins histone macro H2A (mH2A) and heterochromatin protein 1 beta (HP1β) in human fibroblasts during replicative senescence in culture, and for the first time, an age-associated increase in these heterochromatin marks in several tissues of mice and primates. Mouse lung was characterized by monophasic mH2A expression histograms at both ages, and an increase in mean staining intensity at old age. In the mouse liver, we observed increased age-associated localization of mH2A to regions of pericentromeric heterochromatin. In the skeletal muscle, we found two populations of cells with either low or high mH2A levels. This pattern of expression was similar in mouse and baboon, and showed a clear increase in the proportion of nuclei with high mH2A levels in older animals. The frequencies of cells displaying evidence of increased heterochromatinization are too high to be readily accounted for by replicative or oncogene-induced cellular senescence, and are prominently found in terminally differentiated, postmitotic tissues that are not conventionally thought to be susceptible to senescence. Our findings distinguish specific chromatin states in individual cells of mammalian tissues, and provide a foundation to investigate further the progressive epigenetic changes that occur during aging.

Published
2010

42. The nerve hemoglobin of the bivalve mollusc Spisula solidissima : molecular cloning, ligand binding studies, and phylogenetic analysis

Author

Dewilde, Sylvia, Ebner, Bettina, Vinck, Evi, Gilany, Kambiz, Hankeln, Thomas, Burmester, Thorsten, Kreiling, Jill A., Reinisch, Carol L., Vanfleteren, Jacques R., Kiger, Laurent, Marden, Michael C., Hundahl, Christian, Fago, Angela, Van Doorslaer, Sabine, Moens, Luc, Dewilde, Sylvia, Ebner, Bettina, Vinck, Evi, Gilany, Kambiz, Hankeln, Thomas, Burmester, Thorsten, Kreiling, Jill A., Reinisch, Carol L., Vanfleteren, Jacques R., Kiger, Laurent, Marden, Michael C., Hundahl, Christian, Fago, Angela, Van Doorslaer, Sabine, and Moens, Luc

Abstract

Author Posting. © American Society for Biochemistry and Molecular Biology, 2006. This article is posted here by permission of American Society for Biochemistry and Molecular Biology for personal use, not for redistribution. The definitive version was published in Journal of Biological Chemistry 281 (2006): 5364-5372, doi:10.1074/jbc.M509486200., Members of the hemoglobin (Hb) superfamily are present in nerve tissue of several vertebrate and invertebrate species. In vertebrates they display hexacoordinate heme iron atoms and are typically expressed at low levels (µM). Their function is still a matter of debate. In invertebrates they have a hexa- or pentacoordinate heme iron, are mostly expressed at high levels (mM), and have been suggested to have a myoglobin-like function. The native Hb of the surf clam, Spisula solidissima, composed of 162 amino acids, does not show specific deviations from the globin templates. UV-visible and resonance Raman spectroscopy demonstrate a hexacoordinate heme iron. Based on the sequence analogy, the histidine E7 is proposed as a sixth ligand. Kinetic and equilibrium measurements show a moderate oxygen affinity (P50 ~0.6 torr) and no cooperativity. The histidine binding affinity is 100-fold lower than in neuroglobin. Phylogenetic analysis demonstrates a clustering of the S. solidissima nerve Hb with mollusc Hbs and myoglobins, but not with the vertebrate neuroglobins. We conclude that invertebrate nerve Hbs expressed at high levels are, despite the hexacoordinate nature of their heme iron, not essentially different from other intracellular Hbs. They most likely fulfill a myoglobin-like function and enhance oxygen supply to the neurons, This study was supported in part by Inserm, University of Paris-XI, by European Union Grant QLG3-CT-2002-01548, the Deutsche Forschungsgemeinschaft (Ha2103/3 and Bu956/5), by the Fund for Scientific Research of Flanders Grant G.0468.03, and by the Danish Natural Science Research Council.

Published
2009

43. Antimicrobial activity of Limulus blood: role of C-reactive protein (CRP) and Limulus anti-lipopolysaccharide factor (LALF)

Author

Srimal, Subita, Kreiling, Jill, Quigley, James P., Armstrong, Peter B., and Wainwright, Norman

Subjects
Horseshoe crabs -- Physiological aspects, Immune response -- Physiological aspects, Blood proteins -- Physiological aspects, Biological sciences, Physiological aspects
Abstract

The immune defense against invading pathogens is mediated largely by effectors in the blood. Limulus blood contains a single type of blood cell, the granular hemocyte (1), and three abundant [...]

Published
1996

46. Genomes of replicatively senescent cells undergo global epigenetic changes leading to gene silencing and activation of transposable elements

Author

De Cecco, Marco, primary, Criscione, Steven W., additional, Peckham, Edward J., additional, Hillenmeyer, Sara, additional, Hamm, Eliza A., additional, Manivannan, Jayameenakshi, additional, Peterson, Abigail L., additional, Kreiling, Jill A., additional, Neretti, Nicola, additional, and Sedivy, John M., additional

Published
2013
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47. A New invertebrate member of the p53 gene family is developmentally expressed and responds to polychlorinated biphenyls

Author

Jessen-Eller, Kathryn, Kreiling, Jill A., Begley, Gail S., Steele, Marjorie E., Walker, Charles W., Stephens, Raymond E., Reinisch, Carol L., Jessen-Eller, Kathryn, Kreiling, Jill A., Begley, Gail S., Steele, Marjorie E., Walker, Charles W., Stephens, Raymond E., and Reinisch, Carol L.

Abstract

Author Posting. EHP is a publication of the United States government. Publication of EHP lies in the public domain and is therefore without copyright. The definitive version was published in Environmental Health Perspectives Environmental Health Perspectives 110 (2002): 377-385., The cell-cycle checkpoint protein p53 both directs terminal differentiation and protects embryos from DNA damage. To study invertebrate p53 during early development, we identified three differentially expressed p53 family members (p53, p97, p120) in the surf clam, Spisula solidissima. In these mollusks, p53 and p97 occur in both embryonic and adult tissue, whereas p120 is exclusively embryonic. We sequenced, cloned, and characterized p120 cDNA. The predicted protein, p120, resembles p53 across all evolutionarily conserved regions and contains a C-terminal extension with a sterile alpha motif (SAM) as in p63 and p73. These vertebrate forms of p53 are required for normal inflammatory, epithelial, and neuronal development. Unlike clam p53 and p97, p120 mRNA and protein levels are temporally expressed in embryos, with mRNA levels decreasing with increasing p120 protein (R2 = 0.97). Highest surf clam p120 mRNA levels coincide with the onset of neuronal growth. In earlier work we have shown that neuronal development is altered by exposure to polychlorinated biphenyls (PCBs), a neurotoxic environmental contaminant. In this study we show that PCBs differentially affect expression of the three surf clam p53 family members. p120 mRNA and protein are reduced the most and earliest in development, p97 protein shows a smaller and later reduction, and p53 protein levels do not change. For the first time we report that unlike p53 and p97, p120 is specifically embryonic and expressed in a time-dependent manner. Furthermore, p120 responds to PCBs by 48 hr when PCB-induced suppression of the serotonergic nervous system occurs., This research was supported by NCI grant 44307 to C.L. Reinisch and a Grass Fellowship to K. Jessen-Eller.

Published
2005

48. Age-associated increase in heterochromatic marks in murine and primate tissues

Author

Kreiling, Jill A., primary, Tamamori-Adachi, Mimi, additional, Sexton, Alec N., additional, Jeyapalan, Jessie C., additional, Munoz-Najar, Ursula, additional, Peterson, Abigail L., additional, Manivannan, Jayameenakshi, additional, Rogers, Elizabeth S., additional, Pchelintsev, Nikolay A., additional, Adams, Peter D., additional, and Sedivy, John M., additional

Published
2010
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