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Your search keyword '"Kreiswith, Barry N."' showing total 3 results
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3 results on '"Kreiswith, Barry N."'

1. Synergistic effects of sulopenem in combination with cefuroxime or durlobactam against Mycobacterium abscessus

Author

Dousa, Khalid M., primary, Shin, Eunjeong, additional, Kurz, Sebastian G., additional, Plummer, Mark, additional, Nantongo, Mary, additional, Bethel, Christopher R., additional, Taracila, Magdalena A., additional, Nguyen, David C., additional, Kreiswith, Barry N., additional, Daley, Charles L., additional, Remy, Kenneth E., additional, Holland, Steven M., additional, and Bonomo, Robert A., additional

Published
2024
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2. Structure-Based Design of MptpB Inhibitors That Reduce Multidrug-Resistant Mycobacterium tuberculosis Survival and Infection Burden in Vivo

Author

Vickers, Clare F., primary, Silva, Ana P. G., additional, Chakraborty, Ajanta, additional, Fernandez, Paulina, additional, Kurepina, Natalia, additional, Saville, Charis, additional, Naranjo, Yandi, additional, Pons, Miquel, additional, Schnettger, Laura S., additional, Gutierrez, Maximiliano G., additional, Park, Steven, additional, Kreiswith, Barry N., additional, Perlin, David S., additional, Thomas, Eric J., additional, Cavet, Jennifer S., additional, and Tabernero, Lydia, additional

Published
2018
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3. Structure-Based Design of MptpB Inhibitors That Reduce Multidrug-Resistant Mycobacterium tuberculosisSurvival and Infection Burden in Vivo

Author

Vickers, Clare F., Silva, Ana P. G., Chakraborty, Ajanta, Fernandez, Paulina, Kurepina, Natalia, Saville, Charis, Naranjo, Yandi, Pons, Miquel, Schnettger, Laura S., Gutierrez, Maximiliano G., Park, Steven, Kreiswith, Barry N., Perlin, David S., Thomas, Eric J., Cavet, Jennifer S., and Tabernero, Lydia

Abstract

Mycobacterium tuberculosisprotein-tyrosine-phosphatase B (MptpB) is a secreted virulence factor that subverts antimicrobial activity in the host. We report here the structure-based design of selective MptpB inhibitors that reduce survival of multidrug-resistant tuberculosis strains in macrophages and enhance killing efficacy by first-line antibiotics. Monotherapy with an orally bioavailable MptpB inhibitor reduces infection burden in acute and chronic guinea pig models and improves the overall pathology. Our findings provide a new paradigm for tuberculosis treatment.

Published
2018
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