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9. Relationship between COVID-19 and ICU-acquired colonization and infection related to multidrug-resistant bacteria: a prospective multicenter before-after study

Author

Kreitmann, Louis, Jermoumi, Sonia, Vasseur, Margot, Chabani, Myriam, Nourry, Emilie, Richard, Jean-Christophe, and Wallet, Florent

Subjects
Comparative analysis, Health aspects, Bacteria -- Health aspects -- Comparative analysis, Severe acute respiratory syndrome -- Health aspects -- Comparative analysis, Coronaviruses -- Health aspects -- Comparative analysis, Microbial drug resistance -- Comparative analysis -- Health aspects, COVID-19 -- Comparative analysis -- Health aspects, Drug resistance in microorganisms -- Comparative analysis -- Health aspects
Abstract

Author(s): Louis Kreitmann [sup.1] [sup.2], Sonia Jermoumi [sup.1], Margot Vasseur [sup.1], Myriam Chabani [sup.2], Emilie Nourry [sup.2], Jean-Christophe Richard [sup.3], Florent Wallet [sup.4] [sup.5], Pierre Garçon [sup.6], Safaâ Kachmar [sup.6], [...], Purpose Patients presenting the most severe form of coronavirus disease 2019 (COVID-19) pneumonia, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have a prolonged intensive care unit (ICU) stay and are exposed to broad-spectrum antibiotics, but the impact of COVID-19 on antimicrobial resistance is unknown. Methods Observational prospective before-after study in 7 ICUs in France. All consecutive patients with an ICU stay > 48 h and a confirmed SARS-CoV-2 infection were included prospectively and followed for 28 days. Patients underwent systematic screening for colonization with multidrug-resistant (MDR) bacteria upon admission and every week subsequently. COVID-19 patients were compared to a recent prospective cohort of control patients from the same ICUs. The primary objective was to investigate the association of COVID-19 with the cumulative incidence of a composite outcome including ICU-acquired colonization and/or infection related to MDR bacteria (ICU-MDR-col and ICU-MDR-inf, respectively). Results From February 27th, 2020 to June 2nd, 2021, 367 COVID-19 patients were included, and compared to 680 controls. After adjustment for prespecified baseline confounders, the cumulative incidence of ICU-MDR-col and/or ICU-MDR-inf was not significantly different between groups (adjusted sub-hazard ratio [sHR] 1.39, 95% confidence interval [CI] 0.91-2.09). When considering both outcomes separately, COVID-19 patients had a higher incidence of ICU-MDR-inf than controls (adjusted sHR 2.50, 95% CI 1.90-3.28), but the incidence of ICU-MDR-col was not significantly different between groups (adjusted sHR 1.27, 95% CI 0.85-1.88). Conclusion COVID-19 patients had an increased incidence of ICU-MDR-inf compared to controls, but the difference was not significant when considering a composite outcome including ICU-MDR-col and/or ICU-MDR-inf.

Published
2023
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11. Relationship between immunosuppression and intensive care unit-acquired colonization and infection related to multidrug-resistant bacteria: a prospective multicenter cohort study

Author

Kreitmann, Louis, Vasseur, Margot, Jermoumi, Sonia, Perche, Juliette, Richard, Jean-Christophe, Wallet, Florent, and Chabani, Myriam

Subjects
Analysis, Usage, Health aspects, Bacteria -- Analysis -- Health aspects -- Usage, Hospital patients -- Analysis -- Usage -- Health aspects, Imipenem -- Usage, Microbial drug resistance -- Usage -- Analysis -- Health aspects, Methicillin -- Usage, Drug resistance in microorganisms -- Usage -- Analysis -- Health aspects
Abstract

Author(s): Louis Kreitmann [sup.1] [sup.2], Margot Vasseur [sup.1], Sonia Jermoumi [sup.1], Juliette Perche [sup.3], Jean-Christophe Richard [sup.4], Florent Wallet [sup.5] [sup.6], Myriam Chabani [sup.2], Emilie Nourry [sup.2], Pierre Garçon [sup.7], [...], Purpose The impact of immunosuppression on intensive care unit (ICU)-acquired colonization and infection related to multidrug-resistant (MDR) bacteria (ICU-MDR-col and ICU-MDR-inf, respectively) is unknown. Methods We carried out an observational prospective cohort study in 8 ICUs in France (all with single-bed rooms and similar organizational characteristics). All consecutive patients with an ICU stay > 48 h were included, regardless of immune status, and followed for 28 days. Patients underwent systematic screening for colonization with MDR bacteria upon admission and every week subsequently. Immunosuppression was defined as active cancer or hematologic malignancy, neutropenia, solid-organ transplant, use of steroids or immunosuppressive drugs, human immunodeficiency virus infection and genetic. The primary endpoint was the incidence rate of a composite outcome including ICU-MDR-col and/or ICU-MDR-inf. Results 750 patients (65.9% males, median age 65 years) were included, among whom 264 (35.2%) were immunocompromised. Reasons for ICU admission, severity scores and exposure to invasive devices and antibiotics during ICU stay were comparable between groups. After adjustment for center and pre-specified baseline confounders, immunocompromised patients had a lower incidence rate of ICU-MDR-col and/or ICU-MDR-inf (adjusted incidence ratio 0.68, 95% CI 0.52-0.91). When considered separately, the difference was significant for ICU-MDR-col, but not for ICU-MDR-inf. The distribution of MDR bacteria was comparable between groups, with a majority of Enterobacteriacae resistant to third-generation cephalosporins (~ 74%). Conclusion Immunocompromised patients had a significantly lower incidence rate of a composite outcome including ICU-MDR-col and/or ICU-MDR-inf. This finding points to the role of contact precautions and isolation measures, and could have important implications on antibiotic stewardship in this population.

Published
2023
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12. Epidemiology, clinical presentation, and outcomes of 620 patients with eosinophilia in the intensive care unit

Author

Gaillet, Antoine, Bay, Pierre, Péju, Edwige, Ait-Oufella, Hafid, Azoulay, Elie, Benchabane, Nacime, Cerf, Charles, Cohen, Yves, de Prost, Nicolas, Faguer, Stanislas, Geri, Guillaume, Grangé, Steven, Kahn, Jean-Emmanuel, Kreitmann, Louis, Larcher, Romaric, Lefèvre, Guillaume, Mabrouki, Asma, Mekonsto-Dessap, Armand, Panel, Kewin, Pène, Frédéric, Pineton de Chambrun, Marc, Quenot, Jean-Pierre, Tandjaoui-Lambiotte, Yacine, Timsit, Jean-Francois, Vieillard-Baron, Antoine, Dargent, Auguste, Herault, Antoine, and Groh, Matthieu

Published
2023
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16. Immune Profiling Panel Gene Set Identifies Critically Ill Patients With Low Monocyte Human Leukocyte Antigen-DR Expression: Preliminary Results From the REAnimation Low Immune Status Marker (REALISM) Study

Author

Peronnet, Estelle, Blein, Sophie, Venet, Fabienne, Cerrato, Elisabeth, Fleurie, Aurore, Llitjos, Jean-François, Kreitmann, Louis, Terraz, Gabriel, Conti, Filippo, Gossez, Morgane, Rimmelé, Thomas, Textoris, Julien, Lukaszewicz, Anne-Claire, Brengel-Pesce, Karen, Monneret, Guillaume, Arnal, Sophie, Augris-Mathieu, Caroline, Bayle, Frederique, Caruso, Liana, Ber, Charles-Eric, Ben-Amor, Asma, Bellocq, Anne-Sophie, Benatir, Farida, Bertin-Maghit, Anne, Bertin-Maghit, Marc, Boibieux, Andre, Bouffard, Yves, Cejka, Jean-Christophe, Cerro, Valerie, Crozon-Clauzel, Jullien, Davidson, Julien, Debord-Peguet, Sophie, Delwarde, Benjamin, Deleat-Besson, Robert, Delsuc, Claire, Devigne, Bertrand, Fayolle-Pivot, Laure, Faure, Alexandre, Floccard, Bernard, Gatel, Julie, Genin, Charline, Girardot, Thibaut, Gregoire, Arnaud, Hengy, Baptiste, Huriaux, Laetitia, Jadaud, Catherine, Lepape, Alain, Leray, Veronique, Lukaszewicz, Anne-Claire, Marcotte, Guillaume, Martin, Olivier, Matray, Marie, Maucort-Boulch, Delphine, Meuret, Pascal, Monard, Celine, Moriceau, Florent, Monneret, Guillaume, Panel, Nathalie, Rahali, Najia, Rimmele, Thomas, Truc, Cyrille, Uberti, Thomas, Vallin, Helene, Venet, Fabienne, Tissot, Sylvie, Zadam, Abbes, Blein, Sophie, Brengel-Pesce, Karen, Cerrato, Elisabeth, Cheynet, Valerie, Gallet-Gorius, Emmanuelle, Guichard, Audrey, Jourdan, Camille, Koenig, Natacha, Mallet, Francois, Meunier, Boris, Moucade, Virginie, Mommert, Marine, Oriol, Guy, Pachot, Alexandre, Peronnet, Estelle, Schrevel, Claire, Tabone, Olivier, Textoris, Julien, Marcos, Javier Yugueros, Becker, Jeremie, Bequet, Frederic, Bounab, Yacine, Brajon, Florian, Canard, Bertrand, Collus, Muriel, Garcon, Nathalie, Gorse, Irene, Guyard, Cyril, Lavocat, Fabien, Leissner, Philippe, Louis, Karen, Mistretta, Maxime, Moriniere, Jeanne, Mouscaz, Yoann, Noailles, Laura, Perret, Magali, Reynier, Frederic, Riffaud, Cindy, Rol, Mary-Luz, Sapay, Nicolas, Tran, Trang, Vedrine, Christophe, Carre, Christophe, Cortez, Pierre, de Monfort, Aymeric, Florin, Karine, Fraisse, Laurent, Fugier, Isabelle, Payrard, Sandrine, Peleraux, Annick, Quemeneur, Laurence, Griffiths, Andrew, Toetsch, Stephanie, Ashton, Teri, Gough, Peter J., Berger, Scott B., Gardiner, David, Gillespie, Iain, Macnamara, Aidan, Raychaudhuri, Aparna, Smylie, Rob, Tan, Lionel, and Tipple, Craig

Published
2023
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18. Relationship between corticosteroid use and incidence of ventilator-associated pneumonia in COVID-19 patients: a retrospective multicenter study

Author

Saura, Ouriel, Rouzé, Anahita, Martin-Loeches, Ignacio, Povoa, Pedro, Kreitmann, Louis, Torres, Antoni, Metzelard, Matthieu, Du Cheyron, Damien, Lambiotte, Fabien, Tamion, Fabienne, Labruyere, Marie, Boulle Geronimi, Claire, Luyt, Charles-Edouard, Nyunga, Martine, Pouly, Olivier, Thille, Arnaud W., Megarbane, Bruno, Saade, Anastasia, Magira, Eleni, Llitjos, Jean-François, Ioannidou, Iliana, Pierre, Alexandre, Reignier, Jean, Garot, Denis, Baudel, Jean-Luc, Voiriot, Guillaume, Plantefeve, Gaëtan, Morawiec, Elise, Asfar, Pierre, Boyer, Alexandre, Mekontso-Dessap, Armand, Bardaka, Fotini, Diaz, Emili, Vinsonneau, Christophe, Floch, Pierre-Edouard, Weiss, Nicolas, Ceccato, Adrian, Artigas, Antonio, Nora, David, Duhamel, Alain, Labreuche, Julien, and Nseir, Saad

Published
2022
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19. Invasive pulmonary aspergillosis among intubated patients with SARS-CoV-2 or influenza pneumonia: a European multicenter comparative cohort study

Author

Rouzé, Anahita, Lemaitre, Elise, Martin-Loeches, Ignacio, Povoa, Pedro, Diaz, Emili, Nyga, Rémy, Torres, Antoni, Metzelard, Matthieu, Du Cheyron, Damien, Lambiotte, Fabien, Tamion, Fabienne, Labruyere, Marie, Boulle Geronimi, Claire, Luyt, Charles-Edouard, Nyunga, Martine, Pouly, Olivier, Thille, Arnaud W., Megarbane, Bruno, Saade, Anastasia, Magira, Eleni, Llitjos, Jean-François, Ioannidou, Iliana, Pierre, Alexandre, Reignier, Jean, Garot, Denis, Kreitmann, Louis, Baudel, Jean-Luc, Voiriot, Guillaume, Plantefeve, Gaëtan, Morawiec, Elise, Asfar, Pierre, Boyer, Alexandre, Mekontso-Dessap, Armand, Makris, Demosthenes, Vinsonneau, Christophe, Floch, Pierre-Edouard, Marois, Clémence, Ceccato, Adrian, Artigas, Antonio, Gaudet, Alexandre, Nora, David, Cornu, Marjorie, Duhamel, Alain, Labreuche, Julien, and Nseir, Saad

Published
2022
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21. Correction: Epidemiology, clinical presentation, and outcomes of 620 patients with eosinophilia in the intensive care unit

Author

Gaillet, Antoine, Bay, Pierre, Péju, Edwige, Ait-Oufella, Hafid, Azoulay, Elie, Benchabane, Nacime, Cerf, Charles, Cohen, Yves, de Prost, Nicolas, Faguer, Stanislas, Geri, Guillaume, Grangé, Steven, Kahn, Jean-Emmanuel, Kreitmann, Louis, Larcher, Romaric, Lefèvre, Guillaume, Mabrouki, Asma, Mekonsto-Dessap, Armand, Panel, Kewin, Pène, Frédéric, Pineton de Chambrun, Marc, Quenot, Jean-Pierre, Tandjaoui-Lambiotte, Yacine, Timsit, Jean-Francois, Vieillard-Baron, Antoine, Dargent, Auguste, Herault, Antoine, and Groh, Matthieu

Published
2023
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22. Correction to: Relationship between SARS-CoV-2 infection and the incidence of ventilator-associated lower respiratory tract infections: a European multicenter cohort study

Author

Rouzé, Anahita, Martin-Loeches, Ignacio, Povoa, Pedro, Makris, Demosthenes, Artigas, Antonio, Bouchereau, Mathilde, Lambiotte, Fabien, Metzelard, Matthieu, Cuchet, Pierre, Boulle Geronimi, Claire, Labruyere, Marie, Tamion, Fabienne, Nyunga, Martine, Luyt, Charles-Edouard, Labreuche, Julien, Pouly, Olivier, Bardin, Justine, Saade, Anastasia, Asfar, Pierre, Baudel, Jean-Luc, Beurton, Alexandra, Garot, Denis, Ioannidou, Iliana, Kreitmann, Louis, Llitjos, Jean-François, Magira, Eleni, Mégarbane, Bruno, Meguerditchian, David, Moglia, Edgar, Mekontso-Dessap, Armand, Reignier, Jean, Turpin, Matthieu, Pierre, Alexandre, Plantefeve, Gaetan, Vinsonneau, Christophe, Floch, Pierre-Edouard, Weiss, Nicolas, Ceccato, Adrian, Torres, Antoni, Duhamel, Alain, and Nseir, Saad

Published
2022
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24. Le métabolisme énergétique au cours des états critiques : actes du 8ème Séminaire de Recherche Translationnelle de la Société de Réanimation de Langue Française (Paris, 2 décembre 2022)

Author

De la SRLF, CRT, primary, Radermacher, Peter, additional, Oualha, Mehdi, additional, Stiel, Laure, additional, Vandewalle, Jolien, additional, Jouan, Youenn, additional, Fontaine, Eric, additional, Joffre, Jeremie, additional, Kreitmann, Louis, additional, Benghanem, Sarah, additional, Jung, Boris, additional, Schiff, Manuel, additional, Gaudet, Alexandre, additional, Pickkers, Peter, additional, Sarton, Benjamine, additional, Berger, Mette, additional, Merz, Tamara, additional, Kallel, Hatem, additional, Bréchot, Nicolas, additional, Voiriot, Guillaume, additional, and Préau, Sébastien, additional

Published
2023
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25. Cyclosporine A prevents cardiac arrest-induced acute respiratory failure: a post-hoc analysis of the CYRUS trial

Author

Kreitmann, Louis, Argaud, Laurent, Ovize, Michel, Cour, Martin, Gueugniaud, Pierre-Yves, Zéni, Fabrice, and Tchénio, Xavier

Subjects
Prevention, Cardiac arrest -- Prevention, Respiratory insufficiency -- Prevention, Adult respiratory distress syndrome -- Prevention, Acute respiratory distress syndrome -- Prevention
Abstract

Author(s): Louis Kreitmann [sup.1] [sup.2], Laurent Argaud [sup.1] [sup.2] [sup.3], Michel Ovize [sup.2] [sup.3] [sup.4], Martin Cour [sup.1] [sup.2] [sup.3], Pierre-Yves Gueugniaud, Fabrice Zéni, Xavier Tchénio, Jean-Pierre Quenot, Pascal Beuret, [...]

Published
2020
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26. Association between type of immunosuppression and the incidence, microbiology and outcomes of ventilator-associated lower respiratory tract infections a retrospective multicenter study

Author

Bayon, Constance, primary, Kreitmann, Louis, additional, Martin-Loeches, Ignacio, additional, Póvoa, Pedro, additional, Salluh, Jorge, additional, Rouzé, Anahita, additional, Moreau, Anne-Sophie, additional, Labreuche, Julien, additional, and Nseir, Saad, additional

Published
2023
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28. Relationship between COVID-19 and ICU-Acquired Bloodstream Infections Related to Multidrug-Resistant Bacteria

Author

Piantoni, Antoine, primary, Houard, Marion, additional, Piga, Gaetan, additional, Zebian, Ghadi, additional, Ruffier des Aimes, Sarah, additional, Holik, Bérénice, additional, Wallet, Frédéric, additional, Rouzé, Anahita, additional, Kreitmann, Louis, additional, Loiez, Caroline, additional, Labreuche, Julien, additional, and Nseir, Saad, additional

Published
2023
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29. Relationship between corticosteroid use and incidence of ventilator-associated pneumonia in COVID-19 patients: a retrospective multicenter study

Author

Saura, Ouriel, Rouzé, Anahita, Martin Loeches, Ignacio, Povoa, Pedro, Kreitmann, Louis, Torres Martí, Antoni, Metzelard, Matthieu, Du Cheyron, Damien, Lambiotte, Fabien, Tamion, Fabienne, Labruyere, Marie, Boulle Geronimi, Claire, Luyt, Charles-Edouard, Nyunga, Martine, Pouly, Olivier, Thille, Arnaud Wilfrid, Megarbane, Bruno, Saade, Anastasia, Magira, Eleni, Llitjos, Jean-François, Ioannidou, Iliana, Pierre, Alexandre, Reignier, Jean, Garot, Denis, Baudel, Jean-Luc, Voiriot, Guillaume, Plantefeve, Gaëtan, Morawiec, Elise, Asfar, Pierre, Boyer, Alexandre, Mekontso-Dessap, Armand, Bardaka, Fotini, Diaz, Emili, Vinsonneau, Christophe, Floch, Pierre-Edouard, Weiss, Nicolas, Ceccato, Adrian, Artigas, Antonio, Nora, David, Duhamel, Alain, Labreuche, Julien, Nseir, Saad, and coVAPid Study Group

Subjects
Adult, SARS-CoV-2, Respiradors, Incidence, Adrenocortical hormones, Pneumonia, Ventilator-Associated, COVID-19, Respiratory infections, Pneumònia, Pneumonia, Critical Care and Intensive Care Medicine, Corticosteroides, Infeccions respiratòries, Respiració artificial, Respiration, Artificial, Respirators, Intensive Care Units, Artificial respiration, Humans, Retrospective Studies
Abstract

Background Ventilator-associated pneumonia (VAP) is common in patients with severe SARS-CoV-2 pneumonia. The aim of this ancillary analysis of the coVAPid multicenter observational retrospective study is to assess the relationship between adjuvant corticosteroid use and the incidence of VAP. Methods Planned ancillary analysis of a multicenter retrospective European cohort in 36 ICUs. Adult patients receiving invasive mechanical ventilation for more than 48 h for SARS-CoV-2 pneumonia were consecutively included between February and May 2020. VAP diagnosis required strict definition with clinical, radiological and quantitative microbiological confirmation. We assessed the association of VAP with corticosteroid treatment using univariate and multivariate cause-specific Cox’s proportional hazard models with adjustment on pre-specified confounders. Results Among the 545 included patients, 191 (35%) received corticosteroids. The proportional hazard assumption for the effect of corticosteroids on the incidence of VAP could not be accepted, indicating that this effect varied during ICU stay. We found a non-significant lower risk of VAP for corticosteroid-treated patients during the first days in the ICU and an increased risk for longer ICU stay. By modeling the effect of corticosteroids with time-dependent coefficients, the association between corticosteroids and the incidence of VAP was not significant (overall effect p = 0.082), with time-dependent hazard ratios (95% confidence interval) of 0.47 (0.17–1.31) at day 2, 0.95 (0.63–1.42) at day 7, 1.48 (1.01–2.16) at day 14 and 1.94 (1.09–3.46) at day 21. Conclusions No significant association was found between adjuvant corticosteroid treatment and the incidence of VAP, although a time-varying effect of corticosteroids was identified along the 28-day follow-up.

Published
2023

34. Relationship between ventilator-associated pneumonia and mortality in COVID-19 patients: a planned ancillary analysis of the coVAPid cohort

Author

Nseir, Saad, Martin-Loeches, Ignacio, Povoa, Pedro, Metzelard, Matthieu, Du Cheyron, Damien, Lambiotte, Fabien, Tamion, Fabienne, Labruyere, Marie, Makris, Demosthenes, Boulle Geronimi, Claire, Pinetonde Chambrun, Marc, Nyunga, Martine, Pouly, Olivier, Mégarbane, Bruno, Saade, Anastasia, Gomà, Gemma, Magira, Eleni, Llitjos, Jean-François, Torres, Antoni, Ioannidou, Iliana, Pierre, Alexandre, Coelho, Luis, Reignier, Jean, Garot, Denis, Kreitmann, Louis, Baudel, Jean-Luc, Voiriot, Guillaume, Contou, Damien, Beurton, Alexandra, Asfar, Pierre, Boyer, Alexandre, Thille, Arnaud, Mekontso-Dessap, Armand, Tsolaki, Vassiliki, Vinsonneau, Christophe, Floch, Pierre-Edouard, Le Guennec, Loïc, Ceccato, Adrian, Artigas, Antonio, Bouchereau, Mathilde, Labreuche, Julien, Duhamel, Alain, Rouzé, Anahita, Favory, Raphaël, Préau, Sébastien, Jourdain, Mercé, Poissy, Julien, Leger, Piehr Saint, van der Linden, Thierry, Veinstein, Anne, Azoulay, Elie, Pene, Frédéric, Martin, Maelle, Razazi, Keyvan, Plantefeve, Gaëtan, Fartoukh, Muriel, Thevenin, Didier, Guidet, Bertrand, Weiss, Nicolas, Kouatchet, Achille, Salmon, Charlotte, Brunin, Guillaume, Nemlaghi, Safaa, Meguerditchian, David, Argaud, Laurent, Voicu, Sebastian, Luyt, Charles-Edouard, Kowalski, Benjamin, Moglia, Edgar, Morales, Luis, Koutsoukou, Antonia, Mentzelopoulos, Spyros, Nora, David, Boyd, Sean, Maizel, Julien, Cuchet, Pierre, Delforge, Quentin, Quenot, Jean-Pierre, Boyer, Déborah, Cilloniz, Catia, CHU Lille, Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 (UGSF), Université de Lille-Centre National de la Recherche Scientifique (CNRS), CHU Amiens-Picardie, CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Centre hospitalier [Valenciennes, Nord], CHU Rouen, Normandie Université (NU), Endothélium, valvulopathies et insuffisance cardiaque (EnVI), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Centre Hospitalier [Douai, Nord], Institut de cardiologie [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre Hospitalier de Roubaix, Hôpital Saint Philibert [Lomme], Groupement des Hôpitaux de l'Institut Catholique de Lille (GHICL), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), Service de Réanimation Médicale et Toxicologique [Hôpital Lariboisière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Optimisation thérapeutique en Neuropsychopharmacologie (OPTeN (UMR_S_1144 / U1144)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Hopital Saint-Louis [AP-HP] (AP-HP), Hôpital Cochin [AP-HP], Centre Hospitalier de Lens, Centre hospitalier universitaire de Nantes (CHU Nantes), Hôpital Bretonneau, Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Hôpital Edouard Herriot [CHU - HCL], Hospices Civils de Lyon (HCL), CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), CHU Tenon [AP-HP], Centre Hospitalier Victor Dupouy, CHU Charles Foix [AP-HP], Neurophysiologie Respiratoire Expérimentale et Clinique (UMRS 1158), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), CHU Bordeaux [Bordeaux], Centre hospitalier universitaire de Poitiers (CHU Poitiers), CIC - Poitiers, Université de Poitiers-Centre hospitalier universitaire de Poitiers (CHU Poitiers)-Direction Générale de l'Organisation des Soins (DGOS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Groupe de recherche clinique CARMAS (Cardiovascular and Respiratory Manifestations of Acute lung injury and Sepsis) (CARMAS), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Henri Mondor, Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Centre Hospitalier de Béthune (CH Béthune), GHT de l'Artois, Hôpital Duchenne, CH Boulogne sur Mer, Evaluation des technologies de santé et des pratiques médicales - ULR 2694 (METRICS), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), coVAPid study group, Mégarbane, Bruno, and Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-CHU Henri Mondor [Créteil]

Subjects
Male, medicine.medical_treatment, Pneumònia, Critical Care and Intensive Care Medicine, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, 0302 clinical medicine, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Pneumonia, Ventilator-Associated/epidemiology, Medicine, Hospital Mortality, [SDV.MHEP.ME] Life Sciences [q-bio]/Human health and pathology/Emerging diseases, education.field_of_study, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, COVID-19/mortality, Mortality rate, Ventilator-associated pneumonia, Pneumonia, Ventilator-Associated, Medical emergencies. Critical care. Intensive care. First aid, Middle Aged, [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Europe, [SDV.TOX] Life Sciences [q-bio]/Toxicology, Intensive Care Units, Length of Stay/statistics & numerical data, [SDV.TOX]Life Sciences [q-bio]/Toxicology, Cohort, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Female, medicine.medical_specialty, Respiration, Artificial/statistics & numerical data, Coronavirus disease 2019 (COVID-19), Population, Europe/epidemiology, 03 medical and health sciences, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Internal medicine, Mortalitat, Humans, Mortality, education, Aged, Retrospective Studies, Mechanical ventilation, business.industry, RC86-88.9, Research, COVID-19, 030208 emergency & critical care medicine, Retrospective cohort study, Pneumonia, Length of Stay, bacterial infections and mycoses, medicine.disease, Respiration, Artificial, respiratory tract diseases, 030228 respiratory system, [SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, business
Abstract

Background Patients with SARS-CoV-2 infection are at higher risk for ventilator-associated pneumonia (VAP). No study has evaluated the relationship between VAP and mortality in this population, or compared this relationship between SARS-CoV-2 patients and other populations. The main objective of our study was to determine the relationship between VAP and mortality in SARS-CoV-2 patients. Methods Planned ancillary analysis of a multicenter retrospective European cohort. VAP was diagnosed using clinical, radiological and quantitative microbiological criteria. Univariable and multivariable marginal Cox’s regression models, with cause-specific hazard for duration of mechanical ventilation and ICU stay, were used to compare outcomes between study groups. Extubation, and ICU discharge alive were considered as events of interest, and mortality as competing event. Findings Of 1576 included patients, 568 were SARS-CoV-2 pneumonia, 482 influenza pneumonia, and 526 no evidence of viral infection at ICU admission. VAP was associated with significantly higher risk for 28-day mortality in SARS-CoV-2 group (adjusted HR 1.65 (95% CI 1.11–2.46), p = 0.013), but not in influenza (1.74 (0.99–3.06), p = 0.052), or no viral infection groups (1.13 (0.68–1.86), p = 0.63). VAP was associated with significantly longer duration of mechanical ventilation in the SARS-CoV-2 group, but not in the influenza or no viral infection groups. VAP was associated with significantly longer duration of ICU stay in the 3 study groups. No significant difference was found in heterogeneity of outcomes related to VAP between the 3 groups, suggesting that the impact of VAP on mortality was not different between study groups. Interpretation VAP was associated with significantly increased 28-day mortality rate in SARS-CoV-2 patients. However, SARS-CoV-2 pneumonia, as compared to influenza pneumonia or no viral infection, did not significantly modify the relationship between VAP and 28-day mortality. Clinical trial registration The study was registered at ClinicalTrials.gov, number NCT04359693.

Published
2021
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35. Relationship between corticosteroid use and incidence of ventilator-associated pneumonia in COVID-19 patients

Author

Saura, Ouriel, Rouzé, Anahita, Martin-Loeches, Ignacio, Povoa, Pedro, Kreitmann, Louis, Torres, Antoni, Metzelard, Matthieu, Du Cheyron, Damien, Lambiotte, Fabien, Tamion, Fabienne, Labruyere, Marie, Boulle Geronimi, Claire, Luyt, Charles Edouard, Nyunga, Martine, Pouly, Olivier, Thille, Arnaud W., Megarbane, Bruno, Saade, Anastasia, Magira, Eleni, Llitjos, Jean François, Ioannidou, Iliana, Pierre, Alexandre, Reignier, Jean, Garot, Denis, Baudel, Jean Luc, Voiriot, Guillaume, Plantefeve, Gaëtan, Morawiec, Elise, Asfar, Pierre, Boyer, Alexandre, Mekontso-Dessap, Armand, Bardaka, Fotini, Diaz, Emili, Vinsonneau, Christophe, Floch, Pierre Edouard, Weiss, Nicolas, Ceccato, Adrian, Artigas, Antonio, Nora, David, Duhamel, Alain, Labreuche, Julien, Nseir, Saad, and NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)

Subjects
Ventilator-associated lower respiratory tract infections, SARS-CoV-2, Corticosteroids, COVID-19, Critical Care and Intensive Care Medicine
Abstract

Funding This study was supported in part by a grant from the French government through the « Programme Investissement d’Avenir» (I-SITE ULNE) managed by the Agence Nationale de la Recherche (coVAPid project). Prof. Ignacio Martin-Loeches has been supported by SFI (Science Foundation Ireland), Grant number 20/COV/0038. The funders of the study had no role in the study design, data collection, analysis or interpretation, writing of the report or deci sion to submit for publication. BACKGROUND: Ventilator-associated pneumonia (VAP) is common in patients with severe SARS-CoV-2 pneumonia. The aim of this ancillary analysis of the coVAPid multicenter observational retrospective study is to assess the relationship between adjuvant corticosteroid use and the incidence of VAP. METHODS: Planned ancillary analysis of a multicenter retrospective European cohort in 36 ICUs. Adult patients receiving invasive mechanical ventilation for more than 48 h for SARS-CoV-2 pneumonia were consecutively included between February and May 2020. VAP diagnosis required strict definition with clinical, radiological and quantitative microbiological confirmation. We assessed the association of VAP with corticosteroid treatment using univariate and multivariate cause-specific Cox's proportional hazard models with adjustment on pre-specified confounders. RESULTS: Among the 545 included patients, 191 (35%) received corticosteroids. The proportional hazard assumption for the effect of corticosteroids on the incidence of VAP could not be accepted, indicating that this effect varied during ICU stay. We found a non-significant lower risk of VAP for corticosteroid-treated patients during the first days in the ICU and an increased risk for longer ICU stay. By modeling the effect of corticosteroids with time-dependent coefficients, the association between corticosteroids and the incidence of VAP was not significant (overall effect p = 0.082), with time-dependent hazard ratios (95% confidence interval) of 0.47 (0.17-1.31) at day 2, 0.95 (0.63-1.42) at day 7, 1.48 (1.01-2.16) at day 14 and 1.94 (1.09-3.46) at day 21. CONCLUSIONS: No significant association was found between adjuvant corticosteroid treatment and the incidence of VAP, although a time-varying effect of corticosteroids was identified along the 28-day follow-up. publishersversion published

Published
2022

36. Relationship between corticosteroid administration and incidence of ventilator-associated lower respiratory tract infections in COVID-19 patients: a retrospective multicenter study

Author

SAURA, Ouriel, primary, ROUZE, Anahita, additional, MARTIN-LOECHES, Ignacio, additional, POVOA, Pedro, additional, KREITMANN, Louis, additional, TORRES, Antoni, additional, METZELARD, Matthieu, additional, DU CHEYRON, Damien, additional, LAMBIOTTE, Fabien, additional, TAMION, Fabienne, additional, LABRUYERE, Marie, additional, GERONIMI, Claire BOULLE, additional, LUYT, Charles-Edouard, additional, NYUNGA, Martine, additional, POULY, Olivier, additional, THILLE, Arnaud W., additional, MEGARBANE, Bruno, additional, SAADE, Anastasia, additional, MAGIRA, Eleni, additional, LLITJOS, Jean-François, additional, IOANNIDOU, Iliana, additional, PIERRE, Alexandre, additional, REIGNIER, Jean, additional, GAROT, Denis, additional, BAUDEL, Jean-Luc, additional, VOIRIOT, Guillaume, additional, PLANTEFEVE, Gaëtan, additional, MORAWIEC, Elise, additional, ASFAR, Pierre, additional, BOYER, Alexandre, additional, MEKONTSO-DESSAP, Armand, additional, BARDAKA, Fotini, additional, DIAZ, Emilio, additional, VINSONNEAU, Christophe, additional, FLOCH, Pierre-Edouard, additional, WEISS, Nicolas, additional, CECCATO, Adrian, additional, ARTIGAS, Antonio, additional, NORA, David, additional, DUHAMEL, Alain, additional, LABREUCHE, Julien, additional, and NSEIR, Saad, additional

Published
2022
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37. Invasive pulmonary aspergillosis among intubated patients with SARS-CoV-2 or influenza pneumonia: a European multicenter comparative cohort study

Author

Rouze, Anahita Lemaitre, Elise Martin-Loeches, Ignacio and Povoa, Pedro Diaz, Emili Nyga, Remy Torres, Antoni and Metzelard, Matthieu Du Cheyron, Damien Lambiotte, Fabien and Tamion, Fabienne Labruyere, Marie Geronimi, Claire Boulle and Luyt, Charles-Edouard Nyunga, Martine Pouly, Olivier Thille, Arnaud W. Megarbane, Bruno Saade, Anastasia Magira, Eleni and Llitjos, Jean-Francois Ioannidou, Iliana Pierre, Alexandre and Reignier, Jean Garot, Denis Kreitmann, Louis Baudel, Jean-Luc Voiriot, Guillaume Plantefeve, Gaetan Morawiec, Elise Asfar, Pierre Boyer, Alexandre Mekontso-Dessap, Armand and Makris, Demosthenes Vinsonneau, Christophe Floch, Pierre-Edouard Marois, Clemence Ceccato, Adrian Artigas, Antonio Gaudet, Alexandre Nora, David Cornu, Marjorie and Duhamel, Alain Labreuche, Julien Nseir, Saad CoVAPid Study Grp and Rouze, Anahita Lemaitre, Elise Martin-Loeches, Ignacio and Povoa, Pedro Diaz, Emili Nyga, Remy Torres, Antoni and Metzelard, Matthieu Du Cheyron, Damien Lambiotte, Fabien and Tamion, Fabienne Labruyere, Marie Geronimi, Claire Boulle and Luyt, Charles-Edouard Nyunga, Martine Pouly, Olivier Thille, Arnaud W. Megarbane, Bruno Saade, Anastasia Magira, Eleni and Llitjos, Jean-Francois Ioannidou, Iliana Pierre, Alexandre and Reignier, Jean Garot, Denis Kreitmann, Louis Baudel, Jean-Luc Voiriot, Guillaume Plantefeve, Gaetan Morawiec, Elise Asfar, Pierre Boyer, Alexandre Mekontso-Dessap, Armand and Makris, Demosthenes Vinsonneau, Christophe Floch, Pierre-Edouard Marois, Clemence Ceccato, Adrian Artigas, Antonio Gaudet, Alexandre Nora, David Cornu, Marjorie and Duhamel, Alain Labreuche, Julien Nseir, Saad CoVAPid Study Grp

Abstract

Background: Recent multicenter studies identified COVID-19 as a risk factor for invasive pulmonary aspergillosis (IPA). However, no large multicenter study has compared the incidence of IPA between COVID-19 and influenza patients. Objectives: To determine the incidence of putative IPA in critically ill SARS-CoV-2 patients, compared with influenza patients. Methods: This study was a planned ancillary analysis of the coVAPid multicenter retrospective European cohort. Consecutive adult patients requiring invasive mechanical ventilation for > 48 h for SARS-CoV-2 pneumonia or influenza pneumonia were included. The 28-day cumulative incidence of putative IPA, based on Blot definition, was the primary outcome. IPA incidence was estimated using the Kalbfleisch and Prentice method, considering extubation (dead or alive) within 28 days as competing event. Results: A total of 1047 patients were included (566 in the SARS-CoV-2 group and 481 in the influenza group). The incidence of putative IPA was lower in SARS-CoV-2 pneumonia group (14, 2.5%) than in influenza pneumonia group (29, 6%), adjusted cause-specific hazard ratio (cHR) 3.29 (95% CI 1.53-7.02, p= 0.0006). When putative IPA and Aspergillus respiratory tract colonization were combined, the incidence was also significantly lower in the SARS-CoV-2 group, as compared to influenza group (4.1% vs. 10.2%), adjusted cHR 3.21 (95% CI 1.88-5.46, p < 0.0001). In the whole study population, putative IPA was associated with significant increase in 28-day mortality rate, and length of ICU stay, compared with colonized patients, or those with no IPA or Aspergillus colonization. Conclusions: Overall, the incidence of putative IPA was low. Its incidence was significantly lower in patients with SARS-CoV-2 pneumonia than in those with influenza pneumonia.

Published
2022

38. Mortality Prediction in Sepsis With an Immune-Related Transcriptomics Signature: A Multi-Cohort Analysis

Author

Kreitmann, Louis, primary, Bodinier, Maxime, additional, Fleurie, Aurore, additional, Imhoff, Katia, additional, Cazalis, Marie-Angelique, additional, Peronnet, Estelle, additional, Cerrato, Elisabeth, additional, Tardiveau, Claire, additional, Conti, Filippo, additional, Llitjos, Jean-François, additional, Textoris, Julien, additional, Monneret, Guillaume, additional, Blein, Sophie, additional, and Brengel-Pesce, Karen, additional

Published
2022
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41. Additional file 1 of Invasive pulmonary aspergillosis among intubated patients with SARS-CoV-2 or influenza pneumonia: a European multicenter comparative cohort study

Author

Rouz��, Anahita, Lemaitre, Elise, Martin-Loeches, Ignacio, Povoa, Pedro, Diaz, Emili, Nyga, R��my, Torres, Antoni, Metzelard, Matthieu, Du Cheyron, Damien, Lambiotte, Fabien, Tamion, Fabienne, Labruyere, Marie, Boulle Geronimi, Claire, Luyt, Charles-Edouard, Nyunga, Martine, Pouly, Olivier, Thille, Arnaud W., Megarbane, Bruno, Saade, Anastasia, Magira, Eleni, Llitjos, Jean-Fran��ois, Ioannidou, Iliana, Pierre, Alexandre, Reignier, Jean, Garot, Denis, Kreitmann, Louis, Baudel, Jean-Luc, Voiriot, Guillaume, Plantefeve, Ga��tan, Morawiec, Elise, Asfar, Pierre, Boyer, Alexandre, Mekontso-Dessap, Armand, Makris, Demosthenes, Vinsonneau, Christophe, Floch, Pierre-Edouard, Marois, Cl��mence, Ceccato, Adrian, Artigas, Antonio, Gaudet, Alexandre, Nora, David, Cornu, Marjorie, Duhamel, Alain, Labreuche, Julien, and Nseir, Saad

Subjects
Data_FILES
Abstract

Additional file 1. Further details on methods and results.

Published
2022
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42. Additional file 1 of Relationship between corticosteroid use and incidence of ventilator-associated pneumonia in COVID-19 patients: a retrospective multicenter study

Author

Saura, Ouriel, Rouzé, Anahita, Martin-Loeches, Ignacio, Povoa, Pedro, Kreitmann, Louis, Torres, Antoni, Metzelard, Matthieu, Du Cheyron, Damien, Lambiotte, Fabien, Tamion, Fabienne, Labruyere, Marie, Boulle Geronimi, Claire, Luyt, Charles-Edouard, Nyunga, Martine, Pouly, Olivier, Thille, Arnaud W., Megarbane, Bruno, Saade, Anastasia, Magira, Eleni, Llitjos, Jean-François, Ioannidou, Iliana, Pierre, Alexandre, Reignier, Jean, Garot, Denis, Baudel, Jean-Luc, Voiriot, Guillaume, Plantefeve, Gaëtan, Morawiec, Elise, Asfar, Pierre, Boyer, Alexandre, Mekontso-Dessap, Armand, Bardaka, Fotini, Diaz, Emili, Vinsonneau, Christophe, Floch, Pierre-Edouard, Weiss, Nicolas, Ceccato, Adrian, Artigas, Antonio, Nora, David, Duhamel, Alain, Labreuche, Julien, and Nseir, Saad

Abstract

Additional file 1. Supplementary e-figures and e-tables.

Published
2022
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43. Plasmacytoid dendritic cells accumulate in spleens from chronically HIV-infected patients but barely participate in interferon-α expression

Author

Nascimbeni, Michelina, Perié, Leïla, Chorro, Laurent, Diocou, Seckou, Kreitmann, Louis, Louis, Stéphanie, Garderet, Laurent, Fabiani, Bettina, Berger, Anne, Schmitz, Jürgen, Marie, Jean-Pierre, Molina, Thierry Jo, Pacanowski, Jérôme, Viard, Jean-Paul, Oksenhendler, Eric, Beq, Stéphanie, Abehsira-Amar, Orly, Cheynier, Rémi, and Hosmalin, Anne

Published
2009
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44. a planned ancillary analysis of the coVAPid cohort

Author

Nseir, Saad, Martin-Loeches, Ignacio, Povoa, Pedro, Metzelard, Matthieu, Du Cheyron, Damien, Lambiotte, Fabien, Tamion, Fabienne, Labruyere, Marie, Makris, Demosthenes, Boulle Geronimi, Claire, Pinetonde Chambrun, Marc, Nyunga, Martine, Pouly, Olivier, Mégarbane, Bruno, Saade, Anastasia, Gomà, Gemma, Magira, Eleni, Llitjos, Jean François, Torres, Antoni, Ioannidou, Iliana, Pierre, Alexandre, Coelho, Luis, Reignier, Jean, Garot, Denis, Kreitmann, Louis, Baudel, Jean Luc, Voiriot, Guillaume, Contou, Damien, Beurton, Alexandra, Asfar, Pierre, Boyer, Alexandre, Thille, Arnaud W., Mekontso-Dessap, Armand, Tsolaki, Vassiliki, Vinsonneau, Christophe, Floch, Pierre Edouard, Le Guennec, Loïc, Ceccato, Adrian, Artigas, Antonio, Bouchereau, Mathilde, Labreuche, Julien, Duhamel, Alain, Rouzé, Anahita, and NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)

Subjects
COVID-19, Ventilator-associated pneumonia, Mortality, Critical Care and Intensive Care Medicine, respiratory tract diseases
Abstract

Funding: This study was supported in part by a grant from the French government through the «Programme Investissement d’Avenir» (I-SITE ULNE) managed by the Agence Nationale de la Recherche (coVAPid project). The funders of the study had no role in the study design, data collection, analysis, or interpreta tion, writing of the report, or decision to submit for publication. BACKGROUND: Patients with SARS-CoV-2 infection are at higher risk for ventilator-associated pneumonia (VAP). No study has evaluated the relationship between VAP and mortality in this population, or compared this relationship between SARS-CoV-2 patients and other populations. The main objective of our study was to determine the relationship between VAP and mortality in SARS-CoV-2 patients. METHODS: Planned ancillary analysis of a multicenter retrospective European cohort. VAP was diagnosed using clinical, radiological and quantitative microbiological criteria. Univariable and multivariable marginal Cox's regression models, with cause-specific hazard for duration of mechanical ventilation and ICU stay, were used to compare outcomes between study groups. Extubation, and ICU discharge alive were considered as events of interest, and mortality as competing event. FINDINGS: Of 1576 included patients, 568 were SARS-CoV-2 pneumonia, 482 influenza pneumonia, and 526 no evidence of viral infection at ICU admission. VAP was associated with significantly higher risk for 28-day mortality in SARS-CoV-2 (adjusted HR 1.70 (95% CI 1.16-2.47), p = 0.006), and influenza groups (1.75 (1.03-3.02), p = 0.045), but not in the no viral infection group (1.07 (0.64-1.78), p = 0.79). VAP was associated with significantly longer duration of mechanical ventilation in the SARS-CoV-2 group, but not in the influenza or no viral infection groups. VAP was associated with significantly longer duration of ICU stay in the 3 study groups. No significant difference was found in heterogeneity of outcomes related to VAP between the 3 groups, suggesting that the impact of VAP on mortality was not different between study groups. INTERPRETATION: VAP was associated with significantly increased 28-day mortality rate in SARS-CoV-2 patients. However, SARS-CoV-2 pneumonia, as compared to influenza pneumonia or no viral infection, did not significantly modify the relationship between VAP and 28-day mortality. CLINICAL TRIAL REGISTRATION: The study was registered at ClinicalTrials.gov, number NCT04359693. publishersversion published

Published
2021

45. Additional file 1 of Relationship between ventilator-associated pneumonia and mortality in COVID-19 patients: a planned ancillary analysis of the coVAPid cohort

Author

Nseir, Saad, Martin-Loeches, Ignacio, Povoa, Pedro, Metzelard, Matthieu, Du Cheyron, Damien, Lambiotte, Fabien, Tamion, Fabienne, Labruyere, Marie, Makris, Demosthenes, Boulle Geronimi, Claire, Pinetonde Chambrun, Marc, Nyunga, Martine, Pouly, Olivier, Mégarbane, Bruno, Saade, Anastasia, Gomà, Gemma, Magira, Eleni, Llitjos, Jean-François, Torres, Antoni, Ioannidou, Iliana, Pierre, Alexandre, Coelho, Luis, Reignier, Jean, Garot, Denis, Kreitmann, Louis, Baudel, Jean-Luc, Voiriot, Guillaume, Contou, Damien, Beurton, Alexandra, Asfar, Pierre, Boyer, Alexandre, Thille, Arnaud W., Mekontso-Dessap, Armand, Tsolaki, Vassiliki, Vinsonneau, Christophe, Floch, Pierre-Edouard, Le Guennec, Loïc, Ceccato, Adrian, Artigas, Antonio, Bouchereau, Mathilde, Labreuche, Julien, Duhamel, Alain, and Rouzé, Anahita

Subjects
Data_FILES
Abstract

Additional file 1. Online supplementay data.

Published
2021
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46. Early Bacterial Identification among Intubated Patients with COVID-19 or Influenza Pneumonia: A European Multicenter Comparative Clinical Trial

Author

Rouze, Anahita Martin-Loeches, Ignacio Povoa, Pedro and Metzelard, Matthieu Du Cheyron, Damien Lambiotte, Fabien and Tamion, Fabienne Labruyere, Marie Geronimi, Claire Boulle and Nieszkowska, Ania Nyunga, Martine Pouly, Olivier Thille, Arnaud W. Megarbane, Bruno Saade, Anastasia Diaz, Emili and Magira, Eleni Llitjos, Jean-Francois Cilloniz, Catia and Ioannidou, Iliana Pierre, Alexandre Reignier, Jean Garot, Denis Kreitmann, Louis Baudel, Jean-Luc Fartoukh, Muriel and Plantefeve, Gaetan Beurton, Alexandra Asfar, Pierre Boyer, Alexandre Mekontso-Dessap, Armand Makris, Demosthenes and Vinsonneau, Christophe Floch, Pierre-Edouard Weiss, Nicolas and Ceccato, Adrian Artigas, Antonio Bouchereau, Mathilde and Duhamel, Alain Labreuche, Julien Nseir, Saad CoVAPid Study Grp

Subjects
virus diseases, respiratory tract diseases
Abstract

Rationale: Early empirical antimicrobial treatment is frequently prescribed to critically ill patients with coronavirus disease (COVID-19) based on Surviving Sepsis Campaign guidelines. Objectives: We aimed to determine the prevalence of early bacterial identification in intubated patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia, as compared with influenza pneumonia, and to characterize its microbiology and impact on outcomes. Methods: A multicenter retrospective European cohort was performed in 36 ICUs. All adult patients receiving invasivemechanical ventilation.48 hours were eligible if they had SARS-CoV-2 or influenza pneumonia at ICU admission. Bacterial identification was defined by a positive bacterial culture within 48 hours after intubation in endotracheal aspirates, BAL, blood cultures, or a positive pneumococcal or legionella urinary antigen test. Measurements and Main Results: A total of 1,050 patients were included (568 in SARS-CoV-2 and 482 in influenza groups). The prevalence of bacterial identification was significantly lower in patients with SARS-CoV-2 pneumonia compared with patients with influenza pneumonia (9.7 vs. 33.6%; unadjusted odds ratio, 0.21; 95% confidence interval [CI], 0.15-0.30; adjusted odds ratio, 0.23; 95% CI, 0.16-0.33; P, 0.0001). Gram-positive cocci were responsible for 58% and 72% of coinfection in patients with SARS-CoV-2 and influenza pneumonia, respectively. Bacterial identification was associated with increased adjusted hazard ratio for 28-day mortality in patients with SARS-CoV-2 pneumonia (1.57; 95% CI, 1.01-2.44; P = 0.043). However, no significant difference was found in the heterogeneity of outcomes related to bacterial identification between the two study groups, suggesting that the impact of coinfection on mortality was not different between patients with SARS-CoV-2 and influenza. Conclusions: Bacterial identification within 48 hours after intubation is significantly less frequent in patients with SARSCoV-2 pneumonia than patients with influenza pneumonia.

Published
2021

47. Relationship between ventilator-associated pneumonia and mortality in COVID-19 patients: a planned ancillary analysis of the coVAPid cohort (vol 25, 177, 2021)

Author

Nseir, Saad Martin-Loeches, Ignacio Povoa, Pedro Metzelard, Matthieu Du Cheyron, Damien Lambiotte, Fabien Tamion, Fabienne Labruyere, Marie Makris, Demosthenes Boulle Geronimi, Claire Pinetonde Chambrun, Marc Nyunga, Martine and Pouly, Olivier Megarbane, Bruno Saade, Anastasia Goma, Gemma and Magira, Eleni Llitjos, Jean-Francois Torres, Antoni and Ioannidou, Iliana Pierre, Alexandre Coelho, Luis Reignier, Jean Garot, Denis Kreitmann, Louis Baudel, Jean-Luc and Voiriot, Guillaume Contou, Damien Beurton, Alexandra Asfar, Pierre Boyer, Alexandre Thille, Arnaud W. Mekontso-Dessap, Armand Tsolaki, Vassiliki Vinsonneau, Christophe Floch, Pierre-Edouard Le Guennec, Loic Ceccato, Adrian Artigas, Antonio Bouchereau, Mathilde Labreuche, Julien Duhamel, Alain Rouze, Anahita CoVAPid Study Grp

Published
2021

48. Early Bacterial Identification among Intubated Patients with COVID-19 or Influenza Pneumonia: A European Multicenter Comparative Clinical Trial

Author

Rouzé, Anahita, primary, Martin-Loeches, Ignacio, additional, Povoa, Pedro, additional, Metzelard, Matthieu, additional, Du Cheyron, Damien, additional, Lambiotte, Fabien, additional, Tamion, Fabienne, additional, Labruyere, Marie, additional, Boulle Geronimi, Claire, additional, Nieszkowska, Ania, additional, Nyunga, Martine, additional, Pouly, Olivier, additional, Thille, Arnaud W., additional, Megarbane, Bruno, additional, Saade, Anastasia, additional, Diaz, Emili, additional, Magira, Eleni, additional, Llitjos, Jean-François, additional, Cilloniz, Catia, additional, Ioannidou, Iliana, additional, Pierre, Alexandre, additional, Reignier, Jean, additional, Garot, Denis, additional, Kreitmann, Louis, additional, Baudel, Jean-Luc, additional, Fartoukh, Muriel, additional, Plantefeve, Gaëtan, additional, Beurton, Alexandra, additional, Asfar, Pierre, additional, Boyer, Alexandre, additional, Mekontso-Dessap, Armand, additional, Makris, Demosthenes, additional, Vinsonneau, Christophe, additional, Floch, Pierre-Edouard, additional, Weiss, Nicolas, additional, Ceccato, Adrian, additional, Artigas, Antonio, additional, Bouchereau, Mathilde, additional, Duhamel, Alain, additional, Labreuche, Julien, additional, Nseir, Saad, additional, Poissy, Julien, additional, Favory, Raphaël, additional, Preau, Sébastien, additional, Jourdain, Mercè, additional, Boyd, Sean, additional, Coelho, Luis, additional, Cuchet, Pierre, additional, Zarrougui, Wafa, additional, Boyer, Déborah, additional, Quenot, Jean-Pierre, additional, Imouloudene, Mehdi, additional, Luyt, Charles-Edouard, additional, van der Linden, Thierry, additional, Bardin, Justine, additional, Voicu, Sebastian, additional, Azoulay, Elie, additional, Goma, Gemma, additional, Pene, Frédéric, additional, Torres, Antoni, additional, Thevenin, Didier, additional, Ehrmann, Stéphan, additional, Argaud, Laurent, additional, Guidet, Bertrand, additional, Voiriot, Guillaume, additional, Contou, Damien, additional, Le Marec, Julien, additional, Demiselle, Julien, additional, Meguerditchian, David, additional, Razazi, Keyvan, additional, Tsolaki, Vassiliki, additional, Sejourne, Caroline, additional, Brunin, Guillaume, additional, Le Guennec, Loïc, additional, and Morales, Luis, additional

Published
2021
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50. A 9-mRNA signature measured from whole blood by a prototype PCR panel predicts 28-day mortality upon admission of critically ill COVID-19 patients.

Author

Tardiveau, Claire, Monneret, Guillaume, Lukaszewicz, Anne-Claire, Cheynet, Valérie, Cerrato, Elisabeth, Imhoff, Katia, Peronnet, Estelle, Bodinier, Maxime, Kreitmann, Louis, Blein, Sophie, Llitjos, Jean-François, Conti, Filippo, Gossez, Morgane, Buisson, Marielle, Yonis, Hodane, Cour, Martin, Argaud, Laurent, Delignette, Marie-Charlotte, Wallet, Florent, and Dailler, Frederic

Subjects
COVID-19, CRITICALLY ill, HOSPITAL admission & discharge, MORTALITY, PROTOTYPES
Abstract

Immune responses affiliated with COVID-19 severity have been characterized and associated with deleterious outcomes. These approaches were mainly based on research tools not usable in routine clinical practice at the bedside. We observed that a multiplex transcriptomic panel prototype termed Immune Profiling Panel (IPP) could capture the dysregulation of immune responses of ICU COVID-19 patients at admission. Nine transcripts were associated with mortality in univariate analysis and this 9-mRNA signature remained significantly associated with mortality in a multivariate analysis that included age, SOFA and Charlson scores. Using a machine learning model with these 9 mRNA, we could predict the 28-day survival status with an Area Under the Receiver Operating Curve (AUROC) of 0.764. Interestingly, adding patients' age to the model resulted in increased performance to predict the 28-day mortality (AUROC reaching 0.839). This prototype IPP demonstrated that such a tool, upon clinical/analytical validation and clearance by regulatory agencies could be used in clinical routine settings to quickly identify patients with higher risk of death requiring thus early aggressive intensive care. [ABSTRACT FROM AUTHOR]

Published
2022
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